The Associated Press first reported that Zawahiri was killed.
It was not immediately clear where and when Zawahiri died and what element of the U.S. government had carried out the mission.
The CIA carried out a drone strike over the weekend in Kabul, according to officials familiar with the matter. A spokesperson for the Taliban wrote in a tweet that an airstrike had been carried out “on a residential house” in the capital city.
The White House said on Monday that President Biden would give remarks in the evening about “a successful counterterrorism operation,” but did not mention Zawahiri.
This is a developing story and will be updated. Ellen Nakashima and Devlin Barrett contributed to this report.