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Probe Detects “Unknown Features” Inside Martian Moon Phobos




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Phobos has always puzzled astronomers for its asteroid like qualities. Now, using the ESA’s Mars Express spacecraft, they’ve peered beneath its surface.

New Features

The European Space Agency’s (ESA) Mars Express orbiter may be old — it launched back in 2003 — but it’s still uncovering new clues.

Equipped with a new software upgrade to its Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) instrument, the veteran spacecraft has now taken a deeper look into Phobos, one of Mars’ moons whose origins remain an enigma to astronomers.

“We are still at an early stage in our analysis,” said Andrea Cicchetti, a MARSIS team member from Italy’s National Institute for Astrophysics, in a press release. “But we have already seen possible signs of previously unknown features below the moon’s surface. We are excited to see the role that MARSIS might play in finally solving the mystery surrounding Phobos’ origin.”

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Mysterious Moon

Phobos, along with Deimos, are Mars’ two diminutive moons, ominously named after the Greek gods of fear and panic.

Neither, it’s worth noting, is particularly moon-like. They’re both small, with Phobos being less than 17 miles in diameter, and look more like lumpy asteroids than a spherical moon like Earth’s.

These strange but fascinating characteristics, along with their suspected asteroid-like compositions, have long split astronomers on their origins.

“Whether Mars’ two small moons are captured asteroids or made of material ripped from Mars during a collision is an open question,” said Mars Express scientist Colin Wilson in the release. “Their appearance suggests they were asteroids, but the way they orbit Mars arguably suggests otherwise.”

Moonlighting

That’s where MARSIS comes in. With an antenna over 130 feet long, MARSIS is capable of shooting low frequency radio waves that can penetrate deep into Phobos’ core. While many of the waves don’t make it past the surface, the ones that do make it bounce between the internal structures and boundaries of differing materials in the mini-moon’s interior.

Examining these reflections, captured in a “radargram,” could paint scientists a better picture of Phobos’ sub-surface structures, as well as its overall composition. Bright lines in the radargram indicate more or less innocuous surface reflections, but the scientists say there’s evidence of fainter, “lower reflections” that could be signs of subterranean structures.

To get to the bottom of this mystery, the ESA will be collaborating with the Japanese Space Agency to collect samples from Phobos’ surface in the Martian Moon Exploration (MMX) mission, currently set to launch in 2024.

More on Mars: Scientists Searching Mars for Good Caves for Astronauts to Live In

The post Probe Detects “Unknown Features” Inside Martian Moon Phobos appeared first on Futurism.

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Pittsburgh shooting: Multiple shots fired, remains an ‘active scene’ with unknown number of victims, officials say



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 — 

At least six people were injured after a shooting erupted on Friday outside a church in Pittsburgh where a funeral was taking place, according to Pittsburgh Police Commander Rick Ford.

One victim originally reported in critical condition is now in stable condition, among five other individuals also being treated for injuries, Pittsburgh Police Commander Richard Ford said in a second news conference Friday afternoon.

At least one of the victims in stable condition was transported to Children’s Hospital in the city, Ford said.

Agents with the Bureau of Alcohol, Tobacco, Firearms and Explosives “are on scene assisting the Pittsburgh Bureau of Police with this incident,” Special Agent Robert Cucinotta told CNN.

“We cannot comment any further in this matter,” Cucinotta added.

Police were alerted to two ShotSpotter activations shortly after noon Friday. The first alert indicated five rounds shot, and the second alert indicated 15 rounds shot, Ford said. Once at the scene, responding officers determined the gunfire was heard outside the church. It’s believed at least some of the people shot were attending the funeral, Ford said.

Ford said during the second Friday news conference the incident “appears to be obviously a result of a targeted shooting.”

“We do feel that there are people out there that will resort to violence through guns, and that is a danger to anybody when that might take place,” Ford said.

Ford also confirmed there were multiple alleged shooters involved in the incident, but did not offer any further information on potential suspects. The investigation, including the review of video of the incident, is ongoing, Ford said.

Ford also said of the six shooting victims, four transported themselves to nearby hospitals and two were transported by medics. He declined to release their ages or other identifying information at this time since police are still working to notify families.

All schools in the vicinity of the shooting were notified the area is now safe for dismissal of students, Ford said.

Destiny of Faith Church’s senior pastor, the Rev. Brenda Gregg, said in her in 30 years of working in pastoral ministry, Friday’s shooting “has been one of the most devastating days of [her] life.”

Gregg added it was a difficult time “doing a funeral for a young man and being able to work with his family to bring closure to what had happened in their lives, that we had people come to church and fire guns after people.”

Despite the shooting, the church will continue its Halloween harvest event to continue to bring the community together, said Gregg.

“As we think about it, I think we’re stronger together, and that we want to continue to have those things that would make sense in the community, and that is we need a place for our children to come,” Gregg said.

Pittsburgh Mayor Ed Gainey acknowledged the community and the families of the victims are hurting and Friday’s shooting is something they all never expected to happen.

“Just never could have imagined it. Never, that we would shoot up holy ground,” said Gainey. “We will be working around the clock to do whatever is necessary to apprehend those that did this heinous thing today.”

Gainey also urged the community to come forward with any information which might assist the police investigation and help the community heal from the incident.

“If you work with us, if you talk to us, we will get justice, and we will get healing,” Gainey said.

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Scientists Discover a Previously Unknown Plant Mechanism – And Its Impact Could Be Enormous

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The discovery might pave the way for the development of more sustainable crops that can withstand tougher environmental conditions.

Scientists find that meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation

A previously unidentified mechanism for reprogramming gene expression during the transition when one cell differentiates into another has been uncovered by Albert Cairó, Karel Riha, and their colleagues. The mechanism occurs at the conclusion of meiosis, a specialized cell division required for sexual reproduction, and allows germ cells and pollen to differentiate.

This mechanism involves the dynamic localization of essential regulatory components into intracellular condensates that resemble liquid droplets. This process is directly tied to seed production and may offer up new avenues for generating more sustainable crops that can withstand harsher environmental conditions. The findings were recently published in the prestigious journal Science

A field caterpillar flower captured by light microscopy. Credit: Central European Institute of Technology – Masaryk University

Cells are not static things; they change from one type to another. The activation of a certain collection of genes influences how cells specialize in completing specific tasks and when they divide or differentiate. Cell biologists like Albert Cairó and Karel Riha use a combination of sophisticated scientific methods to investigate the plant’s micro-world. Cellular biology is currently undergoing a revolution, with the traditional perspective of cell organization being expanded to new horizons.

“Now we know that the cell not only contains traditional organelles delineated by a membrane but many molecular processes are confined inside less defined membrane-less organelles, also called biomolecular condensates (biocondensates). During the last ten years, the importance of these biocondensates has started being recognized. We now contribute to this field by showing how a specific type of biocondensate forms at the end of meiosis and inhibits protein synthesis,” explains Albert Cairó, the first author of this research.

“This, on the one hand, terminates the meiotic processes, but on the other hand, it marks the beginning of a genetically different generation of cells,” adds Cairó. But this is not all. The research team believes that analogous mechanisms also act in other organisms and cellular settings, including cell differentiation or stress responses.

The discovery of Karel Riha lab members could have an enormous societal impact.

Albert Cairó and Karel Riha. Credit: Central European Institute of Technology – Masaryk University

“We live in a state of climate emergency. Even though plants can fight against a huge variety of stresses, including high temperatures and drought, their development and reproduction can be severely impaired. This means that we are at risk of a dramatic reduction in crop yield, just when the yield has to be increased to satisfy human needs. And that’s why plant research should now be one of the priorities,” explains the corresponding author and research group leader Karel Riha.

The lab’s primary mission is to shed light on fundamental biological processes closely linked to plant reproduction and seed formation, which in many crops translates into yield.

“The research findings show that biomolecular condensates play an important role in plant fertility, and their behavior is likely linked to environmental stress. It is therefore obvious that our discovery is the first step into developing new solutions resulting in sustained crop production under harsher conditions,” explains Albert Cairó.

The technical approaches the team had to perform are genuinely admirable, and the publication of this research in Science is reassuring that Riha’s lab is going in the right direction.

The path to the discovery

Studying meiosis in the model plant Arabidopsis thaliana is particularly challenging. The research team focused on extraordinary and rare cells hidden in 0.1-0.4 mm small floral buds. Moreover, the meiotic division stages that are the study’s focus occur fast – the whole process takes five to six hours. Therefore, they are not easy to capture. The research team must use state-of-the-art technologies and a significant portion of creativity and imagination to investigate this process.

Riha’s team had to establish conditions for live imaging of meiotic division inside the anther (the part of the stamen that contains pollen). The team used advanced microscopy and became one of the two labs in the world that were able to observe plant meiosis live. Another piece of essential expertise the team acquired was the mastery of protoplast technology. Protoplasts are isolated plant cells that have been deprived of their surrounding cell wall, which makes them easy to genetically manipulate and visualize under the microscope. This technology allowed the team to elucidate some problems more quickly and efficiently than using meiotic cells.

Anna Vargova contributed significantly to understanding the newly described complex mechanism. Pavlina Mikulkova provided expertise and lent her magic hand during live cell imaging of meiosis using the Lightsheet microscope. The research team was supported by the CEITEC core facility CELLIM and by the Plant Sciences Core Facility. The research took more than eight years and was financed by the Czech Ministry of Education Youth and Sports grant project REMAP. “It would be extremely difficult to develop such a complex project without the long-term funding we had. In fact, at one point, it felt like our limit was just our imagination, and I believe that this was crucial for our far-reaching discovery,” says Albert Cairó.

Reference: “Meiotic exit in Arabidopsis is driven by P-body–mediated inhibition of translation” by Albert Cairo, Anna Vargova, Neha Shukla, Claudio Capitao, Pavlina Mikulkova, Sona Valuchova, Jana Pecinkova, Petra Bulankova and Karel Riha, 4 August 2022, Science.
DOI: 10.1126/science.abo0904

Interestingly, this project did not involve any external collaboration, which is unusual for international research institutes such as CEITEC. In this case, the research team was entering an entirely new direction and the research was concluded exclusively by the members of Karel Riha’s research group.



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Mass fish die-off in German-Polish river blamed on unknown toxic substance

An analysis of river water from Monday showed evidence of “synthetic chemical substances, very probably also with toxic effects for vertebrates,” the ministry said on Thursday, adding that it remained unclear how the substance entered the water.

According to local broadcaster RBB, the state laboratory found high levels of mercury in the water samples.

The head of Poland’s national water management authority told private broadcaster Polsat News that the presence of mercury in the water had yet to be confirmed, however.

“At the moment, these are press reports. We have no confirmation regarding mercury in the Oder,” Przemyslaw Daca, the head of Polish Waters, said.

The ministry in Brandenburg, the state surrounding Berlin, said it had not yet been possible to assess how many fish had died across Poland and Germany.

“The chains of communication between the Polish and German sides did not work in this case,” Brandenburg environment minister Axel Vogel said, adding that German authorities still had received no notification from Poland on the incident.

In a warning sent to the public earlier this week, Germans in the Uckermark and Barnim districts, home to rolling hills and a nature reserve, advised citizens to avoid contact with water from the Oder and an adjacent canal.

Tons of dead fish have been found since late July in the river Oder.

Polish Prime Minister Mateusz Morawiecki said the waterway would take years to return to normal.

“The scale of this pollution is very big. So big that the Oder may take years to return to a fairly normal state,” Morawiecki said in a regular podcast on Friday.

“It is likely that enormous amounts of chemical waste have been dumped into the river,” he said, adding those responsible would be held accountable.

Late on Friday Morawiecki fired the head of Poland’s national water management authority, Przemyslaw Daca, and the head of the general environmental inspectorate Michal Mistrzak, saying that their institutions should have reacted earlier.

Poland plans to set up a barrier on the Oder near the city of Kostrzyn to collect dead fish flowing down the river, with 150 Territorial Defence Forces soldiers delegated to help with the clean-up.

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New US monkeypox vaccine strategy could be huge boost for supply, but much is unknown

Yet the specific efficacy data for the vaccine is not clear, and some experts argue that not enough is known about how the low-dose intradermal strategy might affect the protection it provides in the real world.

Even at the original dosage size, “there is no traditional assessment of this vaccine,” Dr. Robert Califf, commissioner of the US Food and Drug Administration, said Tuesday. It’s approved for emergency purposes based on studies of immune responses, not clinical outcomes, because there haven’t been smallpox or monkeypox outbreaks large enough to test it.

The intradermal route “may increase the number of available doses in an emergency situation,” the study’s findings say. Last week, the United States declared monkeypox to be a national public health emergency.

US officials said Tuesday that there are plans to collect real-world data on the vaccine and that the National Institutes of Health will launch a clinical trial.

The new federal strategy still calls for two doses of the vaccine given 28 days apart, and it says people who get their first dose subcutaneously can receive their second dose either intradermally or subcutaneously.

But some people have concerns about the shift to a low-dose intradermal strategy.

“While we appreciate that the federal government is finally willing to look for solutions to help rectify the shortage of vaccines, no effort to protect people’s health should come without proper due diligence and research,” David Harvey, executive director of the National Coalition of STD Directors, said in a statement Tuesday.

“We have grave concerns about the limited amount of research that has been done on this dose and administration method, and we fear it will give people a false sense of confidence that they are protected. This approach raises red flag after red flag, and appears to be rushed ahead without data on efficacy, safety, or alternative dosing strategies.”

The Chicago Department of Public Health said Wednesday that it will be going along with the federal plan to stretch out the supply of monkeypox vaccine by changing to smaller doses given in a different way — but it won’t happen overnight.

“I do think it’ll be a couple of weeks until we’re rolled out more broadly,” Chicago Department of Public Health Commissioner Dr. Allison Arwady said.

Other city health departments, like Columbus Public Health in Ohio, are still reviewing the new federal strategy and what it means for their local response.

“Because this guidance is new, we are currently reviewing it to determine the impact on our vaccine effort, staffing and supplies,” Kelli Newman, a spokesperson for Columbus Public Health, wrote in an email to CNN on Wednesday.

A need for ‘formal clinical efficacy data’

The efficacy of Jynneos for the prevention of monkeypox originally was tested in animals that were exposed to the virus, and it can be inferred from antibody responses seen in people who participated in smallpox clinical studies.

But the Jynneos vaccine was originally developed to contribute to the nation’s defense against smallpox as a bioterrorism response effort — so there still isn’t much data on exactly how well it protects against monkeypox infection, even with a subcutaneous dose.

“There is no formal clinical efficacy data with the monkeypox vaccine — but that’s not a criticism of the vaccine. In fact, I think it’s a testament to the vaccine development efforts that we actually have a vaccine for monkeypox already, largely before this major outbreak occurred,” said Dr. Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston.

The FDA approved the Jynneos vaccine in 2019 to prevent smallpox and monkeypox disease, but the approval was mostly to offer a smallpox vaccine option that does not contain live virus. Before then, Sanofi Pasteur Biologics’ ACAM2000 was the only FDA-approved vaccine for the prevention of smallpox. Jynneos has been the preferred vaccine in the current outbreak because ACAM2000 has the potential for more side effects and is not recommended for people with severely weakened immune systems.

“Jynneos was a second-generation smallpox vaccine whose use case was to be a backup vaccine for individuals who could not get ACAM2000 in the event of a smallpox biological weapons attack,” said Dr. Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security at Johns Hopkins Bloomberg School of Public Health.

“There was no intention of using ACAM2000 or Jynneos for monkeypox,” he said. “Even though they were effective against it, it wasn’t considered something that they were developing it for.”

When Jynneos was approved, FDA officials said its effectiveness for the prevention of smallpox was determined by a clinical study of about 400 healthy adults. Half of them received ACAM2000, and half got Jynneos.

The US Centers for Disease Control and Prevention estimates that the Jynneos and ACAM2000 smallpox vaccines are at least 85% effective in preventing monkeypox.

“Although we don’t have clinical efficacy data, it is likely that Jynneos will be highly effective, because of what we know about the smallpox vaccine and because of the efficacy with Jynneos against monkeypox in animals,” Barouch said.

He added that “in general, vaccines are usually more effective at preventing the severe consequences of the disease than preventing acquisition of infection with the pathogen.”

“We can be confident that this will likely be a highly effective vaccine, but the specifics of it in terms of the exact numerical efficacy — and whether that will be prevention of infection or prevention of severe disease — those details are really not known at this point,” Barouch said. “I do think that high-risk people should be vaccinated, but right now, I don’t think it’s possible to give very precise guidance as to exactly what that protection will look like.”

A chance to ‘greatly improve’ availability

The uncertainties surrounding the effectiveness of the Jynneos vaccine will be magnified by the change to a lower dose of the vaccine in the real world, outside of a clinical trial, Dr. Philip Krause, former deputy director of the FDA’s Office of Vaccines Research and Review, and infectious disease physician Dr. Luciana Borio wrote in Stat News on Tuesday.

“If the vaccine can be administered at lower doses at no risk to effectiveness, lower-dose intradermal injections make sense,” Krause and Borio wrote. “But this strategy could also backfire. If there is a risk to effectiveness, it may be better to focus the available full doses of vaccine on individuals at highest risk — men who have sex with multiple male partners — to provide the best chance of getting the outbreak under control.”

Throughout the outbreak, the vaccine has been given to health-care workers treating people with monkeypox, to close contacts of patients and to people who have been able to find doses at local clinics. The CDC has estimated that at least 1.5 million people in the US are eligible for monkeypox vaccination.

“We have a line out around the corner,” Dr. Stacy Lane, a clinician at the Central Outreach Wellness Center in Pittsburgh, said Tuesday of the demand for the monkeypox vaccine at her clinic.

The US Department of Health and Human Services has delivered more than 670,000 doses of the Jynneos vaccine from the Strategic National Stockpile to support local monkeypox response efforts on the ground.

“In addition, the SNS is preparing to distribute approximately 400,000 additional vials to states and jurisdictions as part of the next phase of the national vaccine strategy,” according to the White House. “Jurisdictions that administer 90% of their current vaccine supply may request additional doses sooner.”

And because of the authorization of intradermal injections, “the 400,000 vials of vaccine in the SNS’s inventory that have been allocated but not yet distributed hold the potential to provide up to 2 million doses using intradermal administration. Additionally, vaccines that have been received by jurisdictions, but not yet administered, are eligible for intradermal administration.”

Lane said the shift to an intradermal strategy could “greatly improve” the availability of vaccine. Her clinic has ordered the shorter syringes needed to administer the vaccine intradermally, the same ones used for tuberculosis testing, she said.

“I ordered those this afternoon,” she said Tuesday, before the FDA issued its authorization.

Lane said many of her patients are worried about getting monkeypox, and she refers them to the ACAM2000 vaccine data as a reference point for how well the Jynneos vaccine may protect against monkeypox.

“What we’re educating people on is that we know from historical data that the ACAM2000 vaccine that was historically given in Africa was about 85% protective against monkeypox. We know that these orthopox families of viruses tend to be responding to the same treatment, as well as the vaccine being somewhat effective,” Lane said.

She added that she does not anticipate any concern around the new vaccination strategy.

“We’re not really seeing any vaccine hesitancy, at least at this point,” she said.

Dr. Paulette Grey Riveria agreed that the intradermal strategy could be an effective way to stretch the supply.

“Given that less vaccine volume is needed for an intradermal versus a subcutaneous dose, intradermal Jynneos injections could be a reasonable option to maximize supply while not compromising vaccine protection,” Grey Riveria, family medicine physician with the virtual health platform PlushCare and a regional medical director for the state of Louisiana, wrote in an email to CNN.

“Scientists are actively studying to determine if immune cells under the skin can activate an antibody response with equal or greater efficiency compared to the subcutaneous route.”

CNN’s Jen Christensen contributed to this report.

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Ancient Microbial “Dark Matter” – Thousands of Unknown Bacterial Species Discovered in Hawaiian Lava Caves

Steve Smith in a Hawaiian cave passage filled with roots of the Kaʻu district on the Island of Hawai`i. Credit: Kenneth Ingham

Centuries-Old Lava Caves of Hawaiʻi Island Contain Thousands of Unknown Bacterial Species

Higher bacterial diversity than scientists expected has been uncovered in the lava caves, lava tubes, and geothermal vents on the big island of Hawaiʻi. The findings have been reported in a new study published today (July 21, 2022) in the journal Frontiers in Microbiology.

This research investigates the variety and interactions within these microbial ecosystems, which illustrate how life may have existed on

“This study points to the possibility that more ancient lineages of bacteria, like the phylum Chloroflexi, may have important ecological ‘jobs,’ or roles,” said first author Dr. Rebecca D Prescott of

Thick microbial mats hang under a rock ledge in steam vents that run along the Eastern Rift Zone on Hawaiʻi Island. Credit: Jimmy Saw

The harshest conditions—the geothermal sites—were expected to have lower diversity than the more established and habitable lava tubes. While the diversity was indeed found to be lower, the team of researchers was surprised to discover that the interactions within these communities were more complex than in locations with higher diversity.

“This leads to the question, do extreme environments help create more interactive microbial communities, with microorganisms more dependent on each other?” said Prescott. “And if so, what is it about extreme environments that helps to create this?”

Since Chloroflexi, and another class called Acidobacteria, were present at nearly all of the locations, they may play essential roles in these communities. However, these were not the most abundant bacteria, and the individual communities from the different sites showed large variations in the diversity and complexity of the microbial interactions. Counterintuitively, the most abundant groups, Oxyphotobacteria and Actinobacteria, were not often ‘hub’ species, suggesting that their roles may be less important to the overall structure of the community.

More questions than answers

Since the current study was based on the partial sequencing of one gene, it cannot accurately determine the species of microbes or their ‘jobs’ in the community. Therefore, further research is needed to help reveal the individual species that are present, as well as to better understand these bacteria’s roles in the environment.

A stalactite formation in a Hawaiian cave system from this study with copper minerals and white microbial colonies. Despite the fact that copper is toxic to many organisms, this formation hosts a microbial community. Credit: Kenneth Ingham

“Overall, this study helps to illustrate how important it is to study microbes in co-culture, rather than growing them alone (as isolates),” said Prescott. “In the natural world, microbes do not grow in isolation. Instead, they grow, live, and interact with many other microorganisms in a sea of chemical signals from those other microbes. This then can alter their gene expression, affecting what their jobs are in the community.”

Beyond the insights about past, or even future, life on Mars, bacteria from volcanic environments can also be useful in understanding how microbes turn volcanic rock (basalt) into soils, as well as bioremediation, biotechnology, and sustainable resource management.

Reference: “Islands Within Islands: Bacterial Phylogenetic Structure and Consortia in Hawaiian Lava Caves and Fumaroles” by Rebecca D. Prescott, Tatyana Zamkovaya, Stuart P. Donachie, Diana E. Northup, Joseph J. Medley, Natalia Monsalve, Jimmy H. Saw, Alan W. Decho, Patrick S. G. Chain and Penelope J. Boston, 21 July 2022, Frontiers in Microbiology.
DOI: 10.3389/fmicb.2022.934708

Funding: NASA Headquarters, George Washington University



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