Tag Archives: trigger

Scientists Warn That Common Food Dye Can Trigger Inflammatory Bowel Diseases

Researchers say that consumption of Allura Red food dye over the long term can be a potential trigger of inflammatory bowel diseases (IBDs), Crohn’s disease, and ulcerative colitis. This food dye is a common ingredient in candies, soft drinks, dairy products, and some cereals.

Scientists found that continual exposure to Allura Red AC harms gut health and promotes inflammation.

Allura Red (also called FD&C Red 40 and Food Red 17), is a common ingredient in food ranging from candies and soft drinks to dairy products and breakfast cereals.

Long-term consumption of Allura Red food dye can be a potential trigger of inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, according to Waliul Khan from McMaster University. Using experimental animal models of IBD, researchers discovered that continual exposure to Allura Red AC harms gut health and promotes inflammation.

The dye directly disrupts gut barrier function and increases the production of serotonin, a hormone/neurotransmitter found in the gut, which subsequently alters gut microbiota composition leading to increased susceptibility to colitis.

Waliul Khan. Credit: McMaster University

Khan said Allura Red (also called FD&C Red 40 and Food Red 17), is a common ingredient in candies, soft drinks, dairy products, and some cereals. The dye is used to add color and texture to foodstuffs, often to attract children.

The use of synthetic food dyes such as Allura Red has increased significantly over the last several decades, but there has been little earlier study of these dyes’ effects on gut health. Khan and his team published their findings on December 20 in the journal

“The literature suggests that the consumption of Allura Red also affects certain allergies, immune disorders, and behavioral problems in children, such as attention deficit hyperactivity disorder.”

Khan said that IBDs are serious chronic inflammatory conditions of the human bowel that affect millions of people worldwide. While their exact causes are still not fully understood, studies have shown that dysregulated immune responses, genetic factors, gut microbiota imbalances, and environmental factors can trigger these conditions.

In recent years there has been significant progress in identifying susceptibility genes and understanding the role of the immune system and host microbiota in the pathogenesis of IBDs. However, similar advances in defining environmental risk factors have lagged, he said.

Khan said that environmental triggers for IBDs include the typical Western diet, which includes processed fats, red and processed meats, sugar, and a lack of fiber. He added that the Western diet and processed food also include large amounts of various additives and dyes.

He added that the study suggests a link between a commonly used food dye and IBDs and warrants further exploration between food dyes and IBDs at experimental, epidemiological, and clinical levels.

Reference: “Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice” by Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg and Waliul I. Khan, 20 December 2022, Nature Communications.
DOI: 10.1038/s41467-022-35309-y

The study was funded by the Canadian Institutes of Health Research.



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Red 40, a food dye found in snacks like Pepsi and Doritos can trigger inflammatory bowel disease

A food dye found in dozens of family favorite snacks may trigger severe bowel diseases, scientists warn. 

Red 40, also known as Allura red, is in several popular candies, sodas and chips – including Doritos, Skittles, and Pepsi – as well as baked goods and cake mix.

But researchers from McMaster University in Ontario, Canada, found the additive can hamper the gut’s ability to absorb nutrients, water and electrolytes, increasing a person’s risk of developing an inflammatory bowel disease. 

They say this wearing down of the body’s defenses could make people more susceptible to ulcerative colitis and Crohn’s disease. 

While the study was conducted in mice, the researchers say the findings translate to humans in Western countries, whose diets typically contain a lot of food coloring.  

Red 40, also known as Allura red, is in several popular candies, sodas and chips – including Doritos, Skittles, and Pepsi – as well as baked goods and cake mix

Lead researcher Dr Waliul Khan said: ‘These findings have important implications in the prevention and management of gut inflammation.’

He added: ‘What we have found is striking and alarming, as this common synthetic food dye is a possible dietary trigger for IBDs.’ 

The findings were published in the journal Nature Communications.  

Inflammatory bowel diseases such as colitis and Crohn’s disease, a chronic condition that causes inflammation in your digestive tract, are estimated to affect about three million Americans.

A major caveat of the study, though, is that a human’s diet would have to contain a higher-than-recommended amount of Red 40 to see the kinds of results reported in the mice. 

Mice who only consumed Red 40 intermittently did not experience increased rates of colitis, suggesting that only humans occasionally consuming food or drinks containing Red 40 would be affected. 

The use of food coloring has increased over the last 100-plus years, but there has been little research into its effect on the gut.

The Food and Drug Administration (FDA) limits the amount of food coloring in food and cosmetics and set the recommended daily limit to 7 mg/kg of body weight.

Still, the chemicals in the dyes have been linked to myriad conditions.

As part of their study, the McMaster scientists gave mouse models Allura Red coloring in their meals for 12 weeks.

They found the additive increased the production of serotonin in the colon and disrupted gut bacteria, prompting cases of colitis, a chronic condition that causes ulcers and sores in the digestive tract.

Serotonin – sometimes dubbed the ‘happy hormone’ – is often talked about for its effects on the brain. Low levels of the hormone are usually a factor in people with depression.

But it is actually the gut that is responsible for producing 95 percent of the total serotonin in the body. 

In the gut, serotonin regulates the normal rhythmic movement of the gut muscle and helps move contents in the intestines along the way. It’s also responsible for the uptake of nutrients, electrolytes and water.

The researchers screened for several common synthetic colorants in a model of human enterochromaffin (EC) cells. 

It affects the colon and the rectum and can cause various issues related to inflammation including abdominal pain and bloating, diarrhea, dehydration, and blood stools.

Dr Khan said: ‘The literature suggests that the consumption of Allura Red also affects certain allergies, immune disorders and behavioural problems in children, such as attention deficit hyperactivity disorder.’

Studies have suggested an association between food coloring consumption to hyperactivity in kids. 

An April 2021 analysis of studies commissioned by the state of California reported that of 25 total studies on the subject, 16 identified some association between food coloring and neurobehavioral problems, ‘in particular exacerbation of attentional problems, such as in children with attention-deficit/hyperactivity disorder (ADHD), and other behavioral outcomes’.

Red 40, as well as Yellow 5, and Yellow 6 contain benzidene, a human and animal carcinogen permitted in low, presumably safe levels in dyes. 

The FDA calculated in 1985 that ingestion of free benzidine raises the cancer risk to just under the ‘concern’ threshold, or 1 cancer in 1 million people.

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Common food dye can trigger inflammatory bowe

 

                                                                                                        Media Release

 

Embargoed by Nature Communications until

Tuesday, Dec. 20, 2022, at 11 a.m.  ET

 

Common food dye can trigger inflammatory bowel diseases, say McMaster researchers

 

Hamilton, ON (Dec. 20, 2022) – Long-term consumption of Allura Red food dye can be a potential trigger of inflammatory bowel diseases (IBDs), Crohn’s disease and ulcerative colitis, says McMaster University’s Waliul Khan. Researchers using experimental animal models of IBD found that continual exposure to Allura Red AC harms gut health and promotes inflammation.

 

The dye directly disrupts gut barrier function and increases the production of serotonin, a hormone/neurotransmitter found in the gut, which subsequently alters gut microbiota composition leading to increased susceptibility to colitis.

 

Khan said Allura Red (also called FD&C Red 40 and Food Red 17), is a common ingredient in candies, soft drinks, dairy products and some cereals. The dye is used to add colour and texture to foodstuffs, often to attract children.

 

The use of synthetic food dyes such as Allura Red has increased significantly over the last several decades, but there has been little earlier study of these dyes’ effects on gut health. Khan and his team published their findings in Nature Communications. Yun Han (Eric) Kwon, who recently completed PhD in Khan’s laboratory, is first author.

 

“This study demonstrates significant harmful effects of Allura Red on gut health and identifies gut serotonin as a critical factor mediating these effects. These findings have important implication in the prevention and management of gut inflammation,” said Khan, the study’s senior author, a professor of the Department of Pathology and Molecular Medicine and a principal investigator of Farncombe Family Digestive Health Research Institute.

 

“What we have found is striking and alarming, as this common synthetic food dye is a possible dietary trigger for IBDs. This research is a significant advance in alerting the public on the potential harms of food dyes that we consume daily,” he said.

 

“The literature suggests that the consumption of Allura Red also affects certain allergies, immune disorders and behavioural problems in children, such as attention deficit hyperactivity disorder.”

 

Khan said that IBDs are serious chronic inflammatory conditions of the human bowel that affect millions of people worldwide. While their exact causes are still not fully understood, studies have shown that dysregulated immune responses, genetic factors, gut microbiota imbalances, and environmental factors can trigger these conditions.

 

In recent years there has been significant progress in identifying susceptibility genes and understanding the role of the immune system and host microbiota in the pathogenesis of IBDs. However, similar advances in defining environmental risk factors have lagged, he said.

 

Khan said that environmental triggers for IBDs include the typical Western diet, which includes processed fats, red and processed meats, sugar and a lack of fibre. He added that the Western diet and processed food also includes large amounts of various additives and dyes.

 

He added that the study suggests a link between a commonly used food dye and IBDs and warrants further exploration between food dyes and IBDs at experimental, epidemiological and clinical levels.

 

The study was funded by the Canadian Institutes of Health Research.

 

-30-

 

Editors:

Pictures of Waliul Khan may be found at: https://bit.ly/3jdynps

 

The paper is available post embargo at: https://go.nature.com/3hALLDA

 

For more information, please contact:

Veronica McGuire

Media Relations

Faculty of Health Sciences

McMaster University

289-776-6952

vmcguir@mcmaster.ca

 


Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Shock wave from sun has opened up a crack in Earth’s magnetic field, and it could trigger a geomagnetic storm

A mysterious shock wave in a gust of solar wind has sent a barrage of high-speed material smashing into Earth’s magnetic field, opening up a crack in the magnetosphere. The barrage of plasma could lead to a geomagnetic storm today (Dec. 19), according to spaceweather.com.

The shockwave’s origins aren’t exactly known, but scientists think it could have come from a coronal mass ejection launched by the sunspot AR3165, a fizzing region on the sun’s surface that released a flurry of at least eight solar flares on Dec. 14, causing a brief radio blackout over the Atlantic Ocean. 

Sunspots are areas on the sun’s surface where powerful magnetic fields, created by the flow of electrical charges, knot into kinks before suddenly snapping. The resulting release of energy launches bursts of radiation called solar flares, or plumes of solar material called coronal mass ejections (CMEs). Once launched, CMEs travel at speeds in the millions of miles per hour, sweeping up charged particles from the solar wind to form a giant, combined wavefront that (if pointed toward Earth) can trigger geomagnetic storms.

Related: Ancient solar storm smashed Earth at the wrong part of the sun’s cycle — and scientists are concerned 

Geomagnetic storms occur when energetic solar debris (mostly consisting of electrons, protons and alpha particles) gets absorbed by, and subsequently compresses, Earth’s magnetic field. The solar particles zip through the atmosphere near the poles where Earth’s protective magnetic field is weakest and agitate oxygen and nitrogen molecules — causing them to release energy in the form of light to form colorful auroras such as the northern lights

The storms can also create cracks in the magnetosphere which remain open for hours at a time, enabling some solar material to stream through and disrupt satellites, radio communications, and power systems.

Thankfully today’s potential storm, predicted to be a G-1 class, will be fairly weak. It may cause minor fluctuations in power grids and impair some satellite functions — including those for mobile devices and GPS systems. It could also cause an aurora to appear as far south as Michigan and Maine

More extreme geomagnetic storms, however, can have far more serious effects. They can not only warp our planet’s magnetic field powerfully enough to send satellites tumbling to Earth, but can disrupt electrical systems and even cripple the internet

The upcoming storm is just the latest in a string of solar attacks fired at Earth as the sun ramps up into the most active phase of its roughly 11-year solar cycle.

Astronomers have known since 1775 that solar activity rises and falls in cycles, but recently, the sun has been more active than expected, with nearly double the sunspot appearances predicted by the National Oceanic and Atmospheric Administration.

Scientists anticipate that the sun’s activity will steadily climb for the next few years, reaching an overall maximum in 2025 before decreasing again.

The largest solar storm in recent history was the 1859 Carrington Event, which released roughly the same energy as 10 billion 1-megaton atomic bombs. After slamming into Earth, the powerful stream of solar particles fried telegraph systems around the world and caused auroras brighter than the light of the full moon to appear as far south as the Caribbean.

If a similar event were to happen today, scientists warn it would cause trillions of dollars’ worth of damage, trigger widespread blackouts, and endanger thousands of lives. A previous solar storm in 1989 released a billion-ton plume of gas that caused a blackout across the entire Canadian province of Quebec, NASA reported.

But this may not even scratch the surface of what our star is capable of hurling at us. Scientists are also investigating the cause of a series of sudden and colossal spikes in radiation levels recorded in ancient tree rings across Earth’s history. A leading theory is that the spikes could have come from solar storms 80 times more powerful than the Carrington Event, but scientists have yet to rule out some other potentially unknown cosmic source.

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Researchers discover how music could be used to trigger a deadly pathogen release

Achamyeleh, Al Faruque and Barua (from left) conducted part of their research into a potential threat to negative pressure facilities in an actual clean room designed to prevent external exposure to dangerous microbes. Credit: Steve Zylius / UCI

Researchers at the University of California, Irvine have discovered that the safe operation of a negative pressure room—a space in a hospital or biological research laboratory designed to protect outside areas from exposure to deadly pathogens—can be disrupted by an attacker armed with little more than a smartphone.

According to UCI cyber-physical systems security experts, who shared their findings with attendees at the Association for Computing Machinery’s recent Conference on Computer and Communications Security in Los Angeles, mechanisms that control airflow in and out of biocontainment facilities can be tricked into functioning irregularly by a sound of a particular frequency, possibly tucked surreptitiously into a popular song.

“Someone could play a piece of music loaded on their smartphone or get it to transmit from a television or other audio device in or near a negative pressure room,” said senior co-author Mohammad Al Faruque, UCI professor of electrical engineering and computer science. “If that music is embedded with a tone that matches the resonant frequency of the pressure controls of one of these spaces, it could cause a malfunction and a leak of deadly microbes.”

Heating, ventilation and air conditioning infrastructure maintains the flow of fresh air into and contaminated air out of a given space. HVAC systems in scientific facilities typically include room pressure monitors, which in turn utilize differential pressure sensors that compare the atmospheres inside and outside rooms.

A brief overview of the attack model – A Wolf in Sheep’s Clothing. Credit: Anomadarshi Barua et al

The researchers said that commonly used differential pressure sensors (DPSs) are vulnerable to remote manipulation, posing a previously unrealized threat to biosafety facilities. They tested their hypothesis on eight industry-standard DPSs from five manufacturers, demonstrating that all the devices operate with resonant frequencies in the audible range and are, therefore, subject to tampering.

“When sound waves collide with the diaphragms inside a DPS, it starts vibrating with the same frequency,” said lead author Anomadarshi Barua, UCI Ph.D. candidate in electrical engineering and computer science. “An informed attacker can use this technique to artificially displace the diaphragm, changing the pressure reading and causing the whole system to malfunction.”

He said that attackers could thwart negative pressure room systems in a variety of ways. They could manipulate them wirelessly or pose as maintenance personnel to place an audio device inside or near such a room. “A more sophisticated attack might involve perpetrators embedding sound-emitting technologies into a DPS before it’s installed in a biocontainment facility,” Barua said.

In their conference presentation, the researchers suggested several countermeasures to prevent a musical assault on biosafety facilities. Sound dampening can be achieved by lengthening the sampling tube of a DPS’s port by as much as 7 meters. The team also proposed enclosing the pressure port in a boxlike structure. Both these measures would reduce the sensitivity of the DPS, Barua said.

Al Faruque said that this research project demonstrates the vulnerabilities of embedded systems to random attacks but stressed that with a little planning and forethought, facilities can be hardened against sabotage.

Joining Al Faruque and Barua on the study was Yonatan Gizachew Achamyeleh, UCI Ph.D. student in electrical engineering and computer science. The study was published as part of the Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security.

More information:
Anomadarshi Barua et al, A Wolf in Sheep’s Clothing, Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security (2022). DOI: 10.1145/3548606.3560643

Full paper (arXiv preprint): A Wolf in Sheep’s Clothing: Spreading Deadly Pathogens Under the Disguise of Popular Music

Provided by
University of California, Irvine

Citation:
Researchers discover how music could be used to trigger a deadly pathogen release (2022, November 17)
retrieved 18 November 2022
from https://techxplore.com/news/2022-11-music-trigger-deadly-pathogen.html

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Is THIS the moment Blueface pulled the trigger? Clip shows the rapper whip out a gun and shoot

Newly revealed footage shows the moment rapper Blueface allegedly pulled out a gun in Las Vegas and fired on a truck driver who had been in a fight with the musician’s crew earlier in the night. 

The 25-year-old, real name Johnathan Jamall Porter, was arrested on Tuesday outside of Lo-Lo’s Chicken & Waffles in an apparent undercover operation.

A black and white video obtained by TMZ, seemingly from a security camera, shows Blueface walking outside of a club and crossing the street on October 8.

A truck then drives up next to him and the driver reportedly asked who was responsible for hitting him during an attack earlier in the evening. 

The video then seems to show the rapper pulling out a gun and firing several shots at the driver of the truck, who sped away from the scene. 

Booking photo: The Las Vegas Metropolitan Police Department released a mugshot photo of Blueface following his arrest on charges stemming from an October shooting

Blueface is seen here walking outside of the Las Vegas club on October 8, just before the shooting occurred

The truck is seen here speeding away as Blueface seemingly fires at the vehicles driver, and he has now been charged with attempted murder with the use of a deadly firearm

Eyewitnesses who saw Blueface arrested on Tuesday said six to eight officers in unmarked vehicles were present. 

He faces serious charges for the incident including attempted murder with the use of a deadly firearm, and discharging a gun into a house, building, vehicle or craft, both of which are felonies. 

Video showed him dressed in a brown tracksuit and being handcuffed on the floor before he was helped to his feet and led away to custody. 

The rapper’s girlfriend Chrisean Rock, 22, was with Blueface when he was arrested. 

The Las Vegas Metropolitan Police Department released the following statement: ‘On November 15, 2022 at approximately 2:40 p.m., LVMPD detectives arrested 25-year-old Johnathan Porter on charges stemming from a shooting that took place on October 8, 2022 in the 6300 block of Windy Road.’

Blueface was shown just hours before his arrest with his girlfriend, real name Chrisean Malone, in video she posted on social media for her nearly 2.5 million followers.

They enjoyed light-hearted conversation together in the video and kissed while walking in a hotel hallway.

‘Dis was 3 hours before they took u from me Jesus Got us NO WEAPON FORMED AGAINST US SHALL PROSPER IM YO ROCK FORever!!!,’ Chrisean wrote in the caption.

She earlier tweeted ‘ugh why gotta take you from me’ along with broken heart emojis and multiple crying face emojis.

On scene: The rapper’s girlfriend Chrisean Rock, shown together last June in Houston, was with Blueface when he was arrested

Rising rapper: The 25-year-old rapper, real name Johnathan Jamall Porter, is shown performing in November 2019 in London

Taken away: Chrisean earlier tweeted ‘ugh why gotta take you from me’ along with broken heart emojis and multiple crying face emojis.

Chrisean later posted a video on her Instagram Stories declaring that she would be standing behind Blueface.

In an update for her fans, Chrisean scolded commenters for telling her to leave the rapper while wearing a Blueface necklace.

She noted that Blueface didn’t leave her when she ‘went in’, apparently referencing her arrest in August after an altercation at an Arizona bar.

Chrisean in the clip said they were going to court on Wednesday and that Blueface was coming home.

She added that nobody should be surprised if she gets another chain with his face and ended with a defiant middle finger.

Blueface scored his most successful single with a remix of his song Thotiana featuring Cardi B and YG that peaked at number eight on the Billboard Hot 100 chart. 

Before arrest: Blueface was shown just hours before his arrest with his girlfriend, real name Chrisean Malone, in video she posted on social media

Social media: Chrisean posted the video for her roughly 2 million followers on Instagram

He released his debut studio album Find The Beat in 2019.

Blueface was born in Los Angeles and played football for Arleta High School in the San Fernando Valley area.

He started rapping in January 2017 under the stage name Blueface Bleedem, a reference to his ties to the School Yard Crips street gang.

Blueface previously was arrested in November 2018 in California and charged with shooting at an occupied vehicle after he fired at a gas station robber. He also was arrested in February 2019 for felony gun possession after law enforcement recovered a loaded, unregistered handgun in his possession. 

Standing behind: Chrisean later posted a video on her Instagram Stories declaring that she would be standing behind Blueface while wearing a necklace of the rapper

Coming home: Chrisean in the clip said they were going to court on Wednesday and that Blueface was coming home

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Explainer: NATO’s Articles 4 and 5: How the Ukraine conflict could trigger its defense obligations

WASHINGTON, Nov 15 (Reuters) – A deadly explosion occurred in NATO member Poland’s territory near its border with Ukraine on Tuesday, and the United States and its allies said they were investigating unconfirmed reports the blast had been caused by stray Russian missiles.

The explosion, which firefighters said killed two people, raised concerns of Russia’s war in Ukraine becoming a wider conflict. Polish authorities said it was caused by a Russian-made rocket, but Russia’s defense ministry denied involvement.

If it is determined that Moscow was to blame for the blast, it could trigger NATO’s principle of collective defense known as Article 5, in which an attack on one of the Western alliance’s members is deemed an attack on all, starting deliberations on a potential military response.

As a possible prelude to such a decision, however, Poland has first requested a NATO meeting on Wednesday under the treaty’s Article 4, European diplomats said. That is a call for consultations among the allies in the face of a security threat, allowing for more time to determine what steps to take.

The following is an explanation of Article 5 and what might occur if it is activated:

WHAT IS ARTICLE 5?

Article 5 is the cornerstone of the founding treaty of NATO, which was created in 1949 with the U.S. military as its powerful mainstay essentially to counter the Soviet Union and its Eastern bloc satellites during the Cold War.

The charter stipulates that “the Parties agree that an armed attack against one or more of them in Europe or North America shall be considered an attack against them all.”

“They agree that, if such an armed attack occurs, each of them, in exercise of the right of individual or collective self-defense recognized by Article 51 of the Charter of the United Nations, will assist the Party or Parties so attacked by taking forthwith, individually and in concert with the other Parties, such action as it deems necessary, including the use of armed force, to restore and maintain the security of the North Atlantic area,” it says.

AND WHAT IS ARTICLE 4?

Article 4 states that NATO members “will consult together whenever, in the opinion of any of them, the territorial integrity, political independence or security of any of the Parties is threatened.”

Within hours of the blast in Poland on Tuesday, two European diplomats said that Poland requested a NATO meeting under Article 4 for consultations.

HOW COULD THE UKRAINE WAR TRIGGER ARTICLE 5?

Since Ukraine is not part of NATO, Russia’s invasion in February did not trigger Article 5, though the United States and other member states rushed to provide military and diplomatic assistance to Kyiv.

However, experts have long warned of the potential for a spillover to neighboring countries on NATO’s eastern flank that could force the alliance to respond militarily.

Such action by Russia, either intentional or accidental, has raised the risk of widening the war by drawing other countries directly into the conflict.

IS INVOKING ARTICLE 5 AUTOMATIC?

No. Following an attack on a member state, the others come together to determine whether they agree to regard it as an Article 5 situation.

There is no time limit on how long such consultations could take, and experts say the language is flexible enough to allow each member to decide how far to go in responding to armed aggression against another.

HAS ARTICLE 5 BEEN INVOKED BEFORE?

Yes. Article 5 has been activated once before – on behalf of the United States, in response to the Sept. 11, 2001, hijacked-plane attacks on New York and Washington.

WHAT HAS BIDEN SAID ABOUT ARTICLE 5 COMMITMENTS?

While insisting that the United States has no interest in going to war against Russia, President Joe Biden has said from the start of Moscow’s invasion that Washington would meet its Article 5 commitments to defend NATO partners.

“America’s fully prepared with our NATO allies to defend every single inch of NATO territory. Every single inch,” Biden said at the White House in September.

He had declared earlier that there was “no doubt” that his administration would uphold Article 5.

Reporting by Matt Spetalnick;
Editing by Kieran Murray, Grant McCool and Bradley Perrett

Our Standards: The Thomson Reuters Trust Principles.

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How cold winter weather can trigger health issues  

Winter is a season for festivities, family, friends and chestnuts roasting over the open fire.

But the colder months, shorter days and drier air usher in a host of health issues that many people may still be unaware are linked.

If you have started to feel itchy or seen a little more hair than usual in your shower drain, the cold weather could be to blame. 

Cold air has trouble maintaining moisture, leading to low humidity levels and overall drier air outdoors. Heating air blaring indoors can dry out the air as well. 

Studies show that the drier air can lead to the development of rashes on the skin, scalp issues that can cause hair loss and breathing issues.

While less common, bundling up to protect yourself from the cold could cause problems as well – as constantly taking off and putting on a hat can cause a rare form of alopecia that only one per cent of people suffer.

People who suffer from asthma may suffer from irritated airways caused by the dry air that make their symptoms even worse.

Arthritis sufferers may also notice their joints are getting stiffer and sorer.

When it is cold, the body dedicates blood to core organs, leaving the joints more stiff and causing nerve endings to be more sensitive – leading to more pain.

The lack of daylight can also cause harms to both physical and mental health. 

Perhaps you’ve heard of the ‘winter blues’, which are not just a myth but a symptom of a recognized medical condition. 

Not getting enough time in the sun can deprive the body of vitamin D, leading to loss of skeletal tissue and brittle bones.

More darkness outside can even disrupt a person’s circadian rhythm, causing seasonal depression – and worsening symptoms for some people who already suffer mental health issues.

During the pandemic, many learned the harsh truth that winter changes our behavior, forcing us to spend more time indoors to shelter from the elements, driving up the risk of viruses spreading.

This led to Covid case and hospitalization rates surging during the winter months of recent years. While Covid has subsided in 2022, the flu and other respiratory viruses has taken its place.

MEDailyMail.com reveals what health issues could erupt this winter – and how to treat them 

Many health problems erupt for people over winter. These include seasonal depression and brittle bones caused by changes to sunlight, coughing, hair loss and dry skin caused by a lack of humidity in the air and joint pain caused by the temperature itself

Dry skin 

A Japanese research team wrote in 2013 that dry skin over winter is caused by a decline in a molecule called ceramide in the stratum corneum, the outer most layer of the skin.

Ceramides are fats that help the skin retain moisture and strengthen the skin as a barrier to the outside world. 

Dr Christine Ko (pictured), a dermatology professor at Yale University, told DailyMail.com that the dry winter air can rob a person’s skin of moisture and lead to itchiness and rashe

The Japanese scientists recommend eucalyptus extract – drawn from the leaves of a tree native to Australia and Oceania, as a way to reinvigorate and protect ceramides in the skin. 

Going from outside, where the weather is extremely cold, to indoors, where heat is blaring, could cause skin issues according to Dr Christine Ko, a dermatology professor at Yale University.

‘What happens with winter and with the cold, and then going in the heat, people who are prone to have a rash [will suffer one],’ Dr Ko explained. 

The changes in temperature and exposure to dry air can lead to worsening symptoms for people who suffer from eczema.

Hydration is key to skin health and the outdoor air may rob a person’s skin or moisture, causing it to become dry and flaky or even break out into a rash. 

She also says that the indoor air during winter presents a challenge to your skin as well. Because many buildings have their heat on all the time, indoor air is extremely dry.

Dr Ko said that when a person turns on their indoor heating they must also start to put on lotion each day to keep their skin in tact. A humidifier could also be a valuable tool to hydrate the indoor air.

‘If you know every winter you get it than before you turn your heat on – or when you turn your heat on inside – then its time to [start putting the lotion],’ she said. 

Scratching the rash could be the worst thing a person does. By rubbing the itch, a person is removing some protections their skin has and making the situation even worse.

The Yale expert describes it as the ‘itch-scratch’ cycle, where a person will make their rash even worse by trying to treat it by scratching.

In most extreme examples this can lead to bleeding at the site of the rash or even infection if bacteria enters a wound.

Dr Ko recommends patients use an oil-based moisturizing cream whenever they leave the shower. The lips can be an often overlooked site for dry skin as well. She recommends frequent use of chap-stick or Vaseline.

For people with severe rashes, she recommends seeing a doctor to treat their condition with topical steroids.

In very rare cases, a person’s skin could even be allergic to the cold. Cold urticaria is a rare condition where a person will experience symptoms like hives and swelling of the hands and lips within minutes of stepping into the cold.

The exact cause is not known. It affects an estimated 0.5 per cent of the population. It is more frequent in younger people.

There are no defined treatments for cold urticaria, and sufferers are advised to bundle up and spend as little time as possible outdoors during cold weather months. 

Hair loss 

WHAT ARE THE CAUSES OF HAIR LOSS?

It is perfectly normal for people to lose small amounts of hair as it replenishes itself and, on average, people can shed between 50 and 100 hairs per day.

However, if people start to lose entire patches of hair or large amounts of it it can be more distressing and potentially a sign of something serious.

Pattern baldness is a common cause of hair loss as people grow older. At least half of men over the age of 50 will lose some of their hair just through the ageing process, according to the British Association of Dermatologists.

Women may lose their hair as they grow older, too.

Other, more concerning causes of hair loss include stress, cancer treatment such as chemotherapy or radiotherapy, weight loss or an iron deficiency.

Most hair loss is temporary, however, and can be expected to grow back. 

Specific medical conditions which cause the hair to fall out include alopecia, a disorder of the immune system; an underactive or overactive thyroid; the skin condition lichen planus or Hodgkin’s lymphoma, a type of cancer. 

People should visit their doctor if their hair starts to fall out in lumps, falls out suddenly, if their scalp itches or burns, and if hair loss is causing them severe stress.

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Dry skin can also mean a dry scalp, leaving a person vulnerable to hair loss. Using a hat to keep your head and ears warm could also be a source of hair loss, experts warn.

Like the rest of the skin, scalp dryness is caused by the low humidity in winter air outdoors, and the dry heated air when a person is inside.

A person suffering from a dry scalp could feel itchiness and inflammation on their scalp. This dries out and damages hair follicles, leading to hair loss as a result.

People who suffer from dandruff will also often see more flakes on their clothes, as the dry air causes more flakiness on their skin.

Itching a dry scalp can also make hair loss more likely as the rubbing damages hair follicles and can cause breakage.

A 2009 report led by the manufacturing giant Proctor & Gamble writes that people dealing with dry scalp conditions are less likely to maintain or grow their hair. 

One of these conditions is psoriasis, a common condition where a person experiences scaly and irritated skin on their scalp. Low levels of exposure to ultraviolet radiation from the sun and dry air over winter cause symptoms to exacerbate.

Psoriasis is linked to hair loss as the dry skin leads to follicle breakage, and itching can also damage the hair.

The cold weather itself is not the culprit in many of these cases, though. A Swiss study from 2009 found that just temperature alone was not enough to cause changes to the hair, and that there is no natural cycle causing a person to lose their hair at certain parts of the year. 

This means that using shampoos and conditioners that replenish the scalp’s moisture can help a person stave off hair loss, even when the weather is cold.

Wearing a hat over the winter can cause damage to a full head of hair as well.  

Constantly wearing a head covering, and putting it on then taking it off throughout the day, can pull on the hair follicles and cause some to come out.

This leads to a condition called traction alopecia. People who tie their hair into tight ponytails or buns may suffer the condition as well.

While alarming, hair loss caused by a dry scalp, psoriasis or traction alopecia is usually not permanent and person’s hair will return with proper maintenance. 

Seasonal depression 

Cold weather comes with less sunlight during the day, and experts warn this could leave many people feeling down.

Seasonal Affective Disorder (SAD), often known as seasonal depression, is a condition that affects 10 to 20 per cent of US adults.

People who suffer from the condition will often feel depressive symptoms during the dog-days of winter that they did not experience in previous months. 

Dr Amin Etkin (pictured), a professor at Stanford University, told DailyMail.com that the lack of sunlight over winter can disrupt a person’s circadian rhythm and lead to mental health issues

It is most common in women, younger people and those that are already suffering from a mood disorder. People who already suffer from anxiety or depression along with SAD will have worsened symptoms during these months.

Dr Amin Etkin, a professor at Stanford University, told DailyMail.com the reason people feel sadder when it is dark outside is tied to the body’s circadian rhythm.

The circadian rhythm is a 24-hour cycle that a person’s natural body processes operate on. While many associate it with sleep alone, its impact on the body go much deeper.

‘The light in our environment affects our circadian rhythms,’ Dr Etkin explains.

‘Your body at all levels, brain and an outside the brain, responds to circadian rhythms. Even at the level of single cell genes whose activity is turned on and off in a circadian pattern.

‘There’s a very strong entrainment across multiple levels in your body and as the the timing of the world around you shifts with respect to the amount of light and when things get darker and so forth.’

A 2002 study from Australian researchers found that the amount of serotonin transmitted throughout the brain was lower over winter than in other seasons.

Serotonin is a hormone crucial for regulating emotions, and low levels are tied to anxiety and depression symptoms. 

Dr Etkin also says that some people may be more sensitive to changes in circadian rhythms than others, and those people are more likely to suffer from SAD during colder weather months where there is less sunlight.

‘There’s a portion of people who have really altered circadian rhythms are either delayed the rhythm is delayed relative to what it should be or for advanced too far,’ he continued.

‘That alters their sleep that alters their mood, sleep and mood in turn impact cognition. So you see all of the pieces that come into play.’

While there is no exact solution to SAD or other end of summer blues, people can take steps to manage and reduce the impact.

He recommends adjusting a person’s sleep schedule, if possible, to maximize their exposure to sunlight throughout the day. 

This can include going to bed and waking up earlier during the day to make sure you are awake for the early hours of daylight and spend less waking time during the dark of night. 

Dr Etkin also recommends investing in a SAD lamp, products that can mimic the UV rays of sunlight on a schedule set by a person in their own home. 

A Canadian study published in 1996 found that light therapy was effective at relieving SAD symptoms in ten patients by preventing the loss of tryptophan. Tryptophan is an amino acid that is converted into serotonin within the brain. 

Joint pain

Dr Shelby Johnson (pictured), an orthopedic surgeon at the Mayo Clinic, told DailyMail.com, that the body devotes resources away from the joints in the cold, leading to worse pain from arthritis

People who suffer from arthritis or other joint pains likely already know that these winter months can be brutal to their knees and elbows. 

Joint pain can have many causes, including viral infections, inflammatory conditions like tendinitis or just general injury.

It is most commonly associated with arthritis, though. Conditions like osteoarthritis – where cartilage between the bones wears away – or rheumatoid arthritis – where joint tissues swells, are most common.

Dr Shelby Johnson, an orthopedic surgeon at the Mayo Clinic, told DailyMail.com that people who already suffer these conditions will likely see them worsen when temperatures drop.

‘We see it commonly where people with joint pain and arthritis have exacerbations or worsening of their pain in winter,’ she explained.

Why exactly this is the case has not yet been determined by experts, but Dr Johnson has a few theories.

When the weather turns cold the body circulates less blood to the joints – instead devoting resources to the body’s core. Dr Johnson says that this can lead to joint stiffness, and pain as a result.

The body is also more sensitive to pain in the cold, she says. Blood flow to the bodies nerve endings is limited.

A Moroccan study published in 2020 found that 117 patients who suffered from rheumatoid arthritis reported more tender joints and harsher pain during winter when compared to spring.

Frequent exposure to cold weather has even been linked to the development of rheumatoid arthritis. 

A 2017 Swedish study of 5,000 laborers found that people who worked outside were 50 per cent more likely to develop the condition.

Dr Johnson recommends that people who know they suffer from joint pain layer up this winter and avoid taking part in outdoor activities if possible.

She adds that an overall healthy lifestyle can help reduce all symptoms of arthritis, even those that are not tied to the cold.

Indoor exercise can be a crucial tool as well, she adds: ‘a lot of people with joint pain think that using their joints can exacerbate their symptoms but keeping them moving and fit, keeping them mobile.’

Dry lungs

Dr Raj Dasgupta (pictured), a pulmonologist at the University of Southern California, told DailyMail.com that dryer winter air can lead to irritation of a person’s airwaves

A winter cough is a common nuisance for people who suffer from chronic lung conditions like asthma or chronic obstructive pulmonary disease (COPD) – but even others can face breathing issues this winter.

Dr Raj Dasgupta, a pulmonologist at the University of Southern California, told DailyMail.com that the work the body has to do to stay warm during these months can cause more stress on a person’s breathing.

‘When you are cold your body works harder to stay warm. That puts a lot of additional stress and strain on both your heart and lungs in general,’ he explained. 

The doctor explains there are two types of lung issues a person can face. 

Obstructive problems – where the air has trouble escaping the lungs – include asthma and COPD.  Restrictive issues occur when the air has trouble entering the lungs.  Both are affected by cold, dry, air.

Like other conditions, the dry air can also cause harm to a person’s lungs, he continued ‘a lot of research has shown that its not just the cold air, but it could be the dryness of the cold air.

‘[Cold and dry air] make your airways tighten. It decreases air flow in and out of the lungs… that tightening of the airwaves makes it a lot harder for air to get in and out.’

Dry air can also cause irritation of the lung’s airways. This can constrict airways even more and worsen symptoms of asthma and COPD.

A research team from Finland found in a 2016 study that asthma sufferers were significantly up to 47 per cent likely to experience shortness of breath, 18 per cent more likely to suffer a cough, and 91 per cent more likely to experience shortness of breath over winter when compared to other months.

Scientists also noted increases in wheezing, phlegm production and chest pain among the asthmatics. 

Another Finnish study, published in 2018, of 7,330 patients found that nearly-one-five asthma sufferers had symptoms so severe during winter that it interfered with their ability to perform every day tasks.

Even for people without a chronic lung condition, the dry air can make viral infections like the flu and the respiratory syncytial virus more common.

Some even suffer frequent bloody noses as a result of their dry and irritated airwaves.

Dr Dasgupta recommends asthmatics keep their inhaler or any other medication on hand when they take part on outdoor activities. 

He also tells his patients to wrap a scarf around their mouth as a trick to get more moisture into their airwaves. Instead of losing moisture when exhaling and then replacing it with dry air – moisture will be caught in the scarf and reenter the lungs when inhaled.     

Brittle bones

Many people will suffer osteoporosis in older age, as their skeletal tissue breaks down but is no longer replaced at the same frequency. This can lead to weak, brittle, bones that fracture easily.

Bone loss is often worse over winter, as the body has more trouble absorbing the calcium that is crucial to a strong skeleton.

People often spend more time indoors over summer, and overall exposure to the sun is also lower as daylight hours decrease.

The sun is an excellent source of vitamin D. The vitamin helps the body helps the body process and properly absorb calcium.

A 1996 Boston University report states that vitamin D3, acquired via sun exposure, is necessary to keep calcium levels in the normal range for cellular and bone function. Because the vitamin is rare in food, sunlight is the primary source for many people.

As a result, people likely have lower bone health during these months. This becomes especially worrying for the elderly – where osteoporosis is already a frequent issue.

Dr Johnson, from the Mayo Clinic, recommended that elderly people bundle up before going outdoors, and take caution to avoid falls. Small injuries suffered from a tumble can be devastating for people who already suffer brittle bones.

Calcium and vitamin D supplements can also help weather the effect of bone loss as well.

A 1998 study of 60 elderly women researchers at Maine’s St Joseph Hospital, found that using a daily calcium supplement could stop bone loss from occurring. The control group, who used a placebo, in the study lost three per cent of bone density over the study period.

Drinking calcium-rich milk each day can minimize bone loss as well, the study found.

An Australian study published in 2004 found that vitamin D3 and calcium supplements stopped 43 people from suffering excess bone loss during winter months over a two year period.

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“A Silent Killer” – COVID-19 Shown To Trigger Inflammation in the Brain Without Outward Symptoms for Years

Researchers say the COVID-19 virus affects the brain in a similar way to dementia diseases.

Research led by The University of Queensland (UQ) in Australia has found

“It’s kind of a silent killer, because you don’t see any outward symptoms for many years.” — Dr. Albornoz Balmaceda

The UQ team was led by Professor Trent Woodruff and Dr. Eduardo Albornoz Balmaceda from UQ’s School of Biomedical Sciences, and virologists from the School of Chemistry and Molecular Biosciences.

“We studied the effect of the virus on the brain’s immune cells, ‘microglia’ which are the key cells involved in the progression of brain diseases like Parkinson’s and

“We found the cells effectively became ‘angry’, activating the same pathway that Parkinson’s and Alzheimer’s proteins can activate in disease, the inflammasomes.”

A COVID-19-infected mouse brain showing ‘angry’ microglia in green and SARS-CoV-2 in red. Credit: University of Queensland

Dr. Albornoz Balmaceda said triggering the inflammasome pathway sparked a ‘fire’ in the brain, which begins a chronic and sustained process of killing off neurons.

“It’s kind of a silent killer, because you don’t see any outward symptoms for many years,” Dr. Albornoz Balmaceda said.

“It may explain why some people who’ve had COVID-19 are more vulnerable to developing neurological symptoms similar to Parkinson’s disease.”

The researchers found the spike protein of the virus was enough to start the process and was further exacerbated when there were already proteins in the brain linked to Parkinson’s.

“So if someone is already pre-disposed to Parkinson’s, having COVID-19 could be like pouring more fuel on that ‘fire’ in the brain,” Professor Woodruff said.

“The same would apply for a predisposition for Alzheimer’s and other dementias that have been linked to inflammasomes.”

But the study also found a potential treatment.

The researchers administered a class of UQ-developed inhibitory drugs that are currently in clinical trials with Parkinson’s patients.

“We found it successfully blocked the inflammatory pathway activated by COVID-19, essentially putting out the fire,” Dr. Albornoz Balmaceda said.

“The drug reduced inflammation in both COVID-19-infected mice and the microglia cells from humans, suggesting a possible treatment approach to prevent neurodegeneration in the future.”

Professor Woodruff said while the similarity between how COVID-19 and dementia diseases affect the brain was concerning, it also meant a possible treatment was already in existence.

“Further research is needed, but this is potentially a new approach to treating a virus that could otherwise have untold long-term health ramifications.”  

The research was co-led by Dr. Alberto Amarilla Ortiz and Associate Professor Daniel Watterson and involved 33 co-authors across UQ and internationally.

The study was published on November 1 in Nature’s Molecular Psychiatry.

Reference: “SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein” by Eduardo A. Albornoz, Alberto A. Amarilla, Naphak Modhiran, Sandra Parker, Xaria X. Li, Danushka K. Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Jenny N. Fung, John D. Lee, Devina Paramitha, Rhys Parry, Michael S. Avumegah, Ariel Isaacs, Martin W. Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W. Rajapakse, Ernst J. Wolvetang, Trent P. Munro, Alejandro Rojas-Fernandez, Paul R. Young, Katryn J. Stacey, Alexander A. Khromykh, Keith J. Chappell, Daniel Watterson and Trent M. Woodruff, 1 November 2022, Molecular Psychiatry.
DOI: 10.1038/s41380-022-01831-0



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‘A Silent Killer’: COVID-19 Shown to Trigger Inflammation in the Brain

Summary: COVID-19 infection activates the same inflammatory response in the brain as Parkinson’s disease, a new study reports.

Source: University of Queensland

Research led by The University of Queensland has found COVID-19 activates the same inflammatory response in the brain as Parkinson’s disease.

The discovery identified a potential future risk for neurodegenerative conditions in people who’ve had COVID-19, but also a possible treatment.

The UQ team was led by Professor Trent Woodruff and Dr. Eduardo Albornoz Balmaceda from UQ’s School of Biomedical Sciences, and virologists from the School of Chemistry and Molecular Biosciences.

“We studied the effect of the virus on the brain’s immune cells, ‘microglia’ which are the key cells involved in the progression of brain diseases like Parkinson’s and Alzheimer’s,” Professor Woodruff said.

“Our team grew human microglia in the laboratory and infected the cells with SARS-CoV-2, the virus that causes COVID-19.

“We found the cells effectively became ‘angry,’ activating the same pathway that Parkinson’s and Alzheimer’s proteins can activate in disease, the inflammasomes.”

Dr. Albornoz Balmaceda said triggering the inflammasome pathway sparked a “fire” in the brain, which begins a chronic and sustained process of killing off neurons.

“It’s kind of a silent killer, because you don’t see any outward symptoms for many years,” Dr. Albornoz Balmaceda said.

“It may explain why some people who’ve had COVID-19 are more vulnerable to developing neurological symptoms similar to Parkinson’s disease.”

The researchers found the spike protein of the virus was enough to start the process and was further exacerbated when there were already proteins in the brain linked to Parkinson’s.

“So if someone is already pre-disposed to Parkinson’s, having COVID-19 could be like pouring more fuel on that ‘fire’ in the brain,” Professor Woodruff said.

“The same would apply for a predisposition for Alzheimer’s and other dementias that have been linked to inflammasomes.”

The discovery identified a potential future risk for neurodegenerative conditions in people who’ve had COVID-19, but also a possible treatment. Image is in the public domain

But the study also found a potential treatment.

The researchers administered a class of UQ-developed inhibitory drugs which are currently in clinical trials with Parkinson’s patients.

“We found it successfully blocked the inflammatory pathway activated by COVID-19, essentially putting out the fire,” Dr. Albornoz Balmaceda said.

“The drug reduced inflammation in both COVID-19-infected mice and the microglia cells from humans, suggesting a possible treatment approach to prevent neurodegeneration in the future.”

Professor Woodruff said while the similarity between how COVID-19 and dementia diseases affect the brain was concerning, it also meant a possible treatment was already in existence.

“Further research is needed, but this is potentially a new approach to treating a virus that could otherwise have untold long-term health ramifications.”

The research was co-led by Dr. Alberto Amarilla Ortiz and Associate Professor Daniel Watterson and involved 33 co-authors across UQ and internationally.

About this COVID-19 and neuroinflammation research news

Author: Press Office
Source: University of Queensland
Contact: Press Office – University of Queensland
Image: The image is in the public domain

See also

Original Research: Open access.
“SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein” by Eduardo A. Albornoz et al. Molecular Psychiatry


Abstract

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases of probable Parkinson’s disease.

As microglial NLRP3 inflammasome activation is a major driver of neurodegeneration, here we interrogated whether SARS-CoV-2 can promote microglial NLRP3 inflammasome activation.

Using SARS-CoV-2 infection of transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) as a COVID-19 pre-clinical model, we established the presence of virus in the brain together with microglial activation and NLRP3 inflammasome upregulation in comparison to uninfected mice.

Next, utilising a model of human monocyte-derived microglia, we identified that SARS-CoV-2 isolates can bind and enter human microglia in the absence of viral replication.

This interaction of virus and microglia directly induced robust inflammasome activation, even in the absence of another priming signal. Mechanistically, we demonstrated that purified SARS-CoV-2 spike glycoprotein activated the NLRP3 inflammasome in LPS-primed microglia, in a ACE2-dependent manner.

Spike protein also could prime the inflammasome in microglia through NF-κB signalling, allowing for activation through either ATP, nigericin or α-synuclein. Notably, SARS-CoV-2 and spike protein-mediated microglial inflammasome activation was significantly enhanced in the presence of α-synuclein fibrils and was entirely ablated by NLRP3-inhibition.

Finally, we demonstrate SARS-CoV-2 infected hACE2 mice treated orally post-infection with the NLRP3 inhibitory drug MCC950, have significantly reduced microglial inflammasome activation, and increased survival in comparison with untreated SARS-CoV-2 infected mice.

These results support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson’s disease in COVID-19 infected individuals, and a potential therapeutic avenue for intervention.

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