- ‘Bond King’ Jeffrey Gundlach warns higher-for-longer interest rates could trigger the next Financial Crisis—and advises investors to ‘T-Bill and Chill’ Yahoo Finance
- Layoffs are coming, warns DoubleLine CEO Jeffrey Gundlach CNBC Television
- DoubleLine’s Gundlach says interest rates are going to fall as recession arrives early 2024 CNBC
- Layoffs are coming with a US recession looming, Jeff Gundlach warns Business Insider
- Gundlach says ‘massive interest-expense problem’ could cause next U.S. crisis MarketWatch
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Tag Archives: trigger
New Analysis of ‘Rust’ Gun Finds Alec Baldwin Must Have Pulled Trigger – The New York Times
- New Analysis of ‘Rust’ Gun Finds Alec Baldwin Must Have Pulled Trigger The New York Times
- Alec Baldwin could be charged again in fatal ‘Rust’ shooting as new report claims he pulled trigger Fox News
- New examination of gun used in Rust shooting suggests Alec Baldwin could be charged again Yahoo Entertainment
- Alec Baldwin could be charged again in ‘Rust’ shooting after analysis finds trigger was pulled New York Post
- Actor Alec Baldwin could face more legal trouble for deadly shooting on film set of ‘Rust’ KENS 5: Your San Antonio News Source
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The Fargo shooter used a binary trigger. Here’s what to know about the device that’s worrying police – The Associated Press
- The Fargo shooter used a binary trigger. Here’s what to know about the device that’s worrying police The Associated Press
- Fargo shooter who killed a police officer used ‘binary trigger’ device, had stockpile of weapons at home CNN
- North Dakota AG: Fargo shooter searched for ‘crowds’ Associated Press
- Forum Editorial: Fargo mourns a fallen police officer and struggles to understand an incomprehensible tragedy INFORUM
- First responders receiving mental health support following Friday’s deadly shooting KVLY
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Fargo shooter who killed a police officer used ‘binary trigger’ device, had stockpile of weapons at home – CNN
- Fargo shooter who killed a police officer used ‘binary trigger’ device, had stockpile of weapons at home CNN
- Man who ambushed Fargo officers likely had bigger and bloodier attack in mind, attorney general says The Associated Press
- Man who ambushed Fargo officers searched online for ‘kill fast’ and for crowded area events, AG says Bismarck Tribune
- Forum Editorial: Fargo mourns a fallen police officer and struggles to understand an incomprehensible tragedy INFORUM
- First responders receiving mental health support following Friday’s deadly shooting KVLY
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Ports of Los Angeles and Long Beach back to normal operations after labor shortages trigger shutdowns – KABC-TV
- Ports of Los Angeles and Long Beach back to normal operations after labor shortages trigger shutdowns KABC-TV
- Retailers, manufacturers urge White House to mediate in West Coast ports labor dispute Yahoo Finance
- West Coast port labor issues persist from Los Angeles to Seattle, with supply chain frustration mounting CNBC
- 2 container terminals at Port of Long Beach closed Monday, at least 1 to be closed Tuesday Long Beach Business Journal – Long Beach News
- West Coast dockworkers disrupt trade for a fourth day, says maritime group CNN
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Shocking meteor EXPLOSION forced NASA to trigger its asteroid defense-the Chelyabinsk event – HT Tech
- Shocking meteor EXPLOSION forced NASA to trigger its asteroid defense-the Chelyabinsk event HT Tech
- Experts on the Future of Planetary Defense 10 Years After the Chelyabinsk Asteroid Impact’s 440 Kiloton Explosion SciTechDaily
- The 10-year anniversary of the Chelyabinsk meteor: How it impacted RMNB and Evgeny Kuznetsov’s experience Russian Machine Never Breaks
- This asteroid actually crashed against Earth and changed space science forever HT Tech
- 2013 Chelyabinsk crash: When an asteroid hit Earth and exploded with energy of 35 nuclear bombs India Today
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Astronomers Find Rare Star System That Will Trigger a Kilonova
The universe has no shortage of oddities, and researchers at the National Science Foundation’s NOIRLab have observed another one in the form of a particular binary star system. The system, called CPD-29 2176, will eventually trigger a kilonova, a celestial event in which two neutron stars collide in a massive explosion that forms heavy elements, including gold and platinum.
CPD-29 2176 is located around 11,400 light-years from Earth and was found by researchers using NASA’s Neil Gehrels Swift Observatory. Astronomers then conducted more observations at NOIRLab’s Cerro Tololo Inter-American Observatory in Chile. CPD-29 2176 is home to one neutron star and one massive star that is in the process of going supernova, only to become a second neutron star in the future. Eventually, the two neutron stars will collide, producing a kilonova, an explosion that is thought to produce bursts of gamma rays and large amounts of gold and platinum. The paper documenting the research team’s find is published today in Nature.
“We know that the Milky Way contains at least 100 billion stars and likely hundreds of billions more. This remarkable binary system is essentially a one-in-ten-billion system,” said André-Nicolas Chené in a NOIRLab press release. Chené is a NOIRLab astronomer and an author on the study. “Prior to our study, the estimate was that only one or two such systems should exist in a spiral galaxy like the Milky Way.”
While many stars implode was a powerful supernova when they die, the dying star in CPD-29 2176 is becoming an ultra-stripped supernova. An ultra-stripped supernova lacks the vast amount of force that a typical supernova has, since the dying star has had much of its mass stripped by its companion. The researchers think that the neutron star in the system was also formed with an ultra-stripped supernova and argue that this is the reason that CPD-29 2176 is able to remain as a binary—a typical supernova would have enough power to kick a companion star out of its orbit.
“The current neutron star would have to form without ejecting its companion from the system. An ultra-stripped supernova is the best explanation for why these companion stars are in such a tight orbit,” said lead author Noel D. Richardson, a physics and astronomy professor at Embry-Riddle Aeronautical University, in the NOIRLab release. “To one day create a kilonova, the other star would also need to explode as an ultra-stripped supernova so the two neutron stars could eventually collide and merge.”
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It will take around one million years for the star undergoing ultra-stripped supernova to turn into a neutron star. It is then when the two stars will begin to spiral into each other, eventually resulting in the metal-producing kilonova, according to the research. In these dramatic cosmic endings, we can look forward to the creation of the same elements that make life possible.
More: Watch Four Planets Spin Around a Star 130 Million Light-Years Away
As U.S. and allies arm Ukraine, Russia warns that losing a conventional war “can trigger a nuclear war”
As the United States prepares to announce a new shipment of military hardware for Ukraine and Kyiv pushes its Western partners for modern battle tanks and other heavy weapons, Moscow responded Thursday with a familiar battery of threats. Once again, Russia alluded to its nuclear arsenal in a bid to dissuade the U.S. and its NATO allies from helping Ukraine resist the full-scale invasion President Vladimir Putin launched almost 11 months ago.
“It never occurs to any of the lowlifes to draw an elementary conclusion from this: The defeat of a nuclear power in a conventional war can trigger a nuclear war,” former Russian President Dmitry Medvedev, a top Putin ally who now serves as deputy chairman of the Security Council, said in a post on Telegram.
“Nuclear powers have not lost major conflicts on which their fate depended,” added Medvedev, whose rhetoric has grown increasingly bellicose over the course of the nearly a year-long war.
When asked whether Medvedev’s eyebrow-raising statement represented an escalation of the conflict in Ukraine or Russia’s broader standoff with the West, the Kremlin’s top spokesman said Thursday that the remarks were in line with Russia’s nuclear doctrine.
“There are no contradictions there,” presidential spokesperson Dmitry Peskov said.
Striking an eerily similar note, the head of the Russian Orthodox Church professed in a Thursday sermon that “an attempt to destroy Russia would mean the end of the world.”
“Today there are very big threats to the world, to our country, and to the whole human race, because some crazy people had the idea that the great Russian power, possessing powerful weapons, inhabited by very strong people… who have always come out victorious, that they can be defeated,” said Patriarch Kirill, a staunch backer of all Kremlin policy.
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In Washington, State Department spokesman Vedant Patel said the latest comments were consistent with Russia’s previous statements regarding the use of nuclear weapons.
“This is not the first time that we have seen such kind of rhetoric from Russia broadly … We think provocative rhetoric regarding nuclear weapons is not only dangerous, it is reckless, adds to the risk of miscalculation and candidly it should be avoided,” Patel said. “A nuclear war cannot be won and must never be fought.”
This week, Russian authorities put on a show of force. Putin gave orders to expand the Russian army by around 300,000 people, which would see the number of serving soldiers swell to 1.5 million over the next three years. He also ordered a new army corps and two military districts to be established near European borders.
Defense Minister Sergei Shoigu later laid out an ambitious plan for these changes, saying new military structures would be created around Moscow, St. Petersburg and Karelia. The last location is right on the border with Finland, a Nordic nation that is in the process of becoming a NATO member.
“Self-sufficient” units were also to be deployed to the Ukrainian territories that Russia illegally annexed, Shogui said, despite the Russian military not fully controlling those areas.
“Ensuring the military security of the state, protection of the new federal subjects and critical facilities of the Russian Federation can only be guaranteed by strengthening the key structural components of the Armed Forces,” Shoigu said, according to state-run news agency RIA Novosti.
The Kremlin called the planned military expansion a response to “the proxy war” it claims the West is waging against Russia in Ukraine — a claim Moscow has long wielded to justify its brutal invasion.
Some analysts have noted that the changes announced this week — especially breaking the current, single Western Military District into several smaller ones — in some ways represent a step into the past.
“Shoigu’s announcements since December have been a little surreal to see. In most cases, the posture changes are returning to the past (pre-2010 era), not a step forward,” said Dara Massicot, a senior policy researcher at RAND Corporation. “[His] statements of more billets and more divisions will need more people and equipment to populate them (even if they fall short of targets). This is a tall order to achieve by 2026 without major changes to the Russian economy and personnel system.”
On Wednesday, Putin toured a defense enterprise, the Obukhovsky Plant in St. Petersburg, which has been placed under U.S. sanctions, to praise efforts to increase the output of weaponry and heavy machinery.
Russia has lost a significant amount of equipment that has been either destroyed, captured by Ukraine or abandoned by retreating Russian soldiers over the last 11 months. Independent Russian and international media outlets have also reported in detail on the myriad cases when poorly equipped Russian soldiers ended up on the front line, pointing towards production difficulties in the country’s military-industrial complex.
Putin told workers at the plant that Russia was justified in calling Ukraine a country full of “neo-Nazis,” and he insisted that victory was “inevitable.”
Mudslides trigger evacuations, close roads in Berkeley Hills
Mudslides in the Berkeley Hills triggered evacuations and closed roads on Monday morning, officials said.
A Nixle alert issued this morning advised residents in the area of Middlefield Road, Wildcat Canyon Road and The Spiral to be prepared to evacuate, the Berkeley Police Department told SFGATE. The alert also asked people to avoid the area.
Berkeley Councilmember Susan Wengraf told SFGATE the mudslide in the Park Hills neighborhood occurred at about 6 a.m. and seven homes were evacuated. One home was red-tagged on Middlefield Road, Wengraf said.
“It’s my understanding that there’s no need to evacuate any further,” she said on the phone at noon.
The Spiral — a short road off Wildcat Canyon Road — and Middlefield Road north of the Crossways, are both closed, Berkeley police said in an advisory.
Wildcat Canyon Road between Sunset and Park Hills roads is also closed due to a mudslide. Authorities responded to the area shortly after 7 a.m.
The ground is still moving and trees can be heard cracking from the slide, Berkeley Fire Battalion Chief Bill Kehoe said around 9 a.m.
A mudslide was also reported Monday morning in the area of Sports Lane and the Clark Kerr campus. UC Berkeley Police asked people to avoid the area.
Journalist Frances Dinkelspiel posted images on Twitter showing a mudslide on Alvarado Road in the Berkeley-Oakland area. “An Oakland police officer just said the Oakland Public Works looked at Alvarado Road slide and said it is so big that the city will have to hire a contractor to clean it up,” Dinkelspiel, the co-founder and former executive editor of Berkeleyside and Cityside wrote. “So the road will be closed for a bit.”
Bay City News contributed to this story. This breaking news story was updated.
Inflammatory Trigger a New Clue in Alzheimer’s and PSP
Summary: An inflammatory trigger like one present during viral infections is elevated in those with Alzheimer’s disease and progressive supranuclear palsy (PSP).
Source: UT San Antonio
Scientists from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) today reported that an inflammatory trigger like one present during viral infections is elevated in Alzheimer’s disease and progressive supranuclear palsy, a rare brain disorder.
“We have identified a new trigger of brain inflammation in these disorders,” said Elizabeth Ochoa, study author from UT Health San Antonio.
The finding published in Science Advances is novel for this reason, she said.
Ochoa, a recent doctoral graduate, and her mentor, Bess Frost, Ph.D., study senior author, are investigators with the Sam and Ann Barshop Institute for Longevity and Aging Studies, the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, and the Department of Cell Systems and Anatomy at UT Health San Antonio. Frost is the Bartell Zachry Distinguished Professor for Research in Neurodegenerative Disorders.
Alzheimer’s disease and progressive supranuclear palsy are marked by toxic deposits of a protein called tau. Their research found that tau-induced “jumping genes”—which can relocate or copy themselves to other locations in the genome—form double-stranded RNA. This abnormal RNA mimics the inflammatory trigger that is also present in viral infections.
“Transposable elements—the so-called jumping genes—are a new area of interest in understanding Alzheimer’s disease. Our study provides new insights into how they can drive the disease process in addition to their ability to jump,” Ochoa said. “These double-stranded RNAs look like a virus to the immune system even though the jumping genes are a part of our normal genome.”
The researchers detected accumulation of double-stranded RNA in postmortem brain tissue from patients with Alzheimer’s disease and progressive supranuclear palsy and in brains of mouse and fruit fly models of tauopathy.
“We found substantial deposits of double-stranded RNA in astrocytes, which are cells that provide metabolic support for neurons, regulate neurotransmitters and maintain blood-brain barrier integrity,” Frost said. “In aging and disease, astrocytes respond to injury and disruption of the neuronal environment. Our findings open new doors for understanding astrocyte biology and their role in transposable element control.”
Loss of neurons, which are cells of the central nervous system, is progressive in Alzheimer’s and other neurodegenerative diseases.
The researchers conducted experiments in fruit flies to quickly test their questions about double-stranded RNA and inflammation in the brain. “To ensure that what we found in our fruit fly experiments is relevant to mammalian disease, we also studied brain tissue from mouse models and from postmortem human brains affected by tauopathy,” Ochoa said.
“As we are currently targeting jumping gene activation in a local Phase II clinical trial for patients with Alzheimer’s disease, it’s important to understand the full repertoire of toxic molecules, including double-stranded RNAs, that jumping genes produce,” Frost said.
Ochoa recently earned her Ph.D. from the Cell Biology, Genetics and Molecular Medicine Discipline of the Integrated Biomedical Sciences program at UT Health San Antonio. She earned her undergraduate degree from Seattle University.
Frost, associate professor of cell systems and anatomy in the Barshop and Biggs institutes at UT Health San Antonio, received the highly competitive Edith and Peter O’Donnell Award in Medicine in 2020 from TAMEST, the Texas Academy of Medicine, Engineering, Science and Technology. She was also a Gold Medalist in 2022 for the prestigious Oskar Fischer Prize.
About this Alzheimer’s disease and PSP research news
Author: Press Office
Source: UT San Antonio
Contact: Press Office – UT San Antonio
Image: The image is in the public domain
See also
Original Research: Open access.
“Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation” by Elizabeth Ochoa et al. Science Advances
Abstract
Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various model systems of tauopathy report that toxic forms of tau negatively affect nuclear and genomic architecture, identifying pathogenic tau–induced heterochromatin decondensation and consequent retrotransposon activation as a causal mediator of neurodegeneration.
On the basis of their similarity to retroviruses, retrotransposons drive neuroinflammation via toxic intermediates, including double-stranded RNA (dsRNA). We find that dsRNA and dsRNA sensing machinery are elevated in astrocytes of postmortem brain tissue from patients with Alzheimer’s disease and progressive supranuclear palsy and in brains of tau transgenic mice.
Using a Drosophila model of tauopathy, we identify specific tau-induced retrotransposons that form dsRNA and find that pathogenic tau and heterochromatin decondensation causally drive dsRNA-mediated neurodegeneration and neuroinflammation.
Our study suggests that pathogenic tau–induced heterochromatin decondensation and retrotransposon activation cause elevation of inflammatory, transposable element–derived dsRNA in the adult brain.