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Coronavirus Los Angeles: New research sheds light on an emerging parallel COVID epidemic

LOS ANGELES (KABC) — Because so many residents in Los Angeles County have dealt with COVID-19 infections, many now view the virus like a common cold or flu.

New research suggests that’s far from the truth.

With concern over COVID waning, a parallel pandemic is emerging.

“We’re still learning about the long term health effects of COVID infections,” said L.A. County Public Health Director Barbara Ferrer.

Dr. Michael Ghobrial with the Cleveland Clinic said they’re seeing it more commonly in younger patients.

This comes as doctors across the country are dealing with a growing number of patients who can’t shake their initial COVID symptoms or have acquired new symptoms that last for at least a month or more. Some cases have been going on for two years.

“The most described symptoms of long COVID include fatigue, reduced exercise capacity, breathing problems, brain fog and loss of taste or smell,” said Ferrer.

Various studies find long COVID, or long haulers syndrome, can strike in all populations.

“It’s more in females compared to males. It’s also more common in patients who have comorbidities,” said Ghobrial.

In a study of several thousand veterans, Ferrer said the new evidence suggests repeated COVID infections increase one’s risk for long haul syndrome.

“Many of these disorders were serious and life changing and included stroke, cognition and memory disorders, peripheral nervous system disorders,” she said. “The risk of having long term health conditions was three times higher for those infected three times compared to those who were uninfected.”

Avoiding infection is the key, and while COVID vaccines and boosters don’t always prevent infection, numerous studies find it can reduce the risk of long COVID.

“Those who had two doses of vaccine before getting COVID had an approximately 75% lower chance of getting long COVID,” said Ferrer. “While those who got three doses had an 84% lower chance of getting long COVID.”

While we have much to learn, Ferrer said getting vaccinated and boosted appears to be one of the simplest ways to significantly reduce your risk.

Copyright © 2022 KABC Television, LLC. All rights reserved.



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Darya Dugina’s death sheds light on the women fronting Russia’s propaganda machine

But Dugina herself played a smaller, public role in advancing Russian soft power — assailing the West in TV appearances at home, while operating a disguised English-language online platform that pushed a pro-Kremlin worldview to Western readers.

In recent years, she had sought to build influence publicly, often with an international audience in mind.

And she was not alone. Dugina was one of a number of influential Russian women on the front lines of Russia’s disinformation war, representing the public face of the wider propaganda effort, both at home and abroad.

“There is a huge machine that works for this propagandistic effort, (and) she was a part of this machine,” said Roman Osadchuk, a Ukraine-based research associate at the Atlantic Council’s Digital Forensic Research Lab (DFRLab), who has investigated Dugina’s writings and digital output since 2020.

“She probably had potential to become an important player,” Osadchuk told CNN.

Her death provides a window into that vast operation, which exists on multiple levels; Dugina emulated the work of high-ranking Kremlin spokespeople, firebrand TV anchors, activists and countless content creators who — like her — pumped out Kremlin-friendly content on Western-facing blogs and websites, many of which have camouflaged origins.

Whatever their reach, “the thing that is similar for all of them is the direction of their effort,” Osadchuk said. “The main idea is (to) sow division and distrust towards the governments in the Western world … (to) create further polarization, or to expose problems and divisions in Western societies.”

A shady website that lambasted the West

For much of her life, Dugina had “followed in her father’s footsteps,” according to Osadchuk.

She used her public speeches, media appearances and website to advance a worldview similar to her father’s, which placed a “heavy-handed basis of the power of traditions,” and saw religion as “a primary part of governance itself.”

“They juxtaposed themselves against the West, which (they argued) is fighting not for family values but for sodomy, sin and represent the worst in people,” he added. Central to her beliefs was a steadfast commitment to Russian imperial objectives.

Dugina’s own appearances on domestic television placed her firmly in the group of analysts and talking heads who advocated for Russia’s war aims on a nightly basis. In one televised discussion before her death, she said the West needed to be “nourished” by Russia’s war in Ukraine in order to “wake up” from its uneducated worldview, according to a clip posted online by BBC Monitoring.
“Many are calling her a ‘child,’ But she wasn’t,” wrote Kamil Galeev, an independent researcher and former fellow at the Wilson Center, a non-partisan policy think tank in Washington, DC, in a lengthy Twitter thread that described Dugina as a “propagandist” and likened her appearances to a number of Russian male pundits.
According to the US State Department, Dugina in 2020 became chief editor of United World International (UWI) — an English and Turkish-language foreign affairs site created by the corporatized propaganda effort “Project Lakhta,” which the department says used fictitious online personas to interfere in US elections.

The website mimics the format of Western think tanks and news blogs, featuring articles by guest contributors from around the world, and aside from the occasional mistranslation, it bears few traces of its Russian origin.

“On the surface it looks like (it holds) a fringe view of the world, but you couldn’t immediately tell that this is something Russian,” said Osadchuk, whose investigation in 2020 revealed that social media accounts owned by Dugina were responsible for creating UWI’s Facebook presence.

“But if you go into the articles themselves, you could read it and see the Russian position all over,” he added.

“If Ukraine is admitted to NATO, it will perish as a state,” one headline on its site declared. A story published four days after Russia’s invasion of Ukraine baselessly claimed that Putin was acting in defense of his country after receiving information of an imminent Ukrainian attack on Russia; another claims that “Ukraine’s accession to NATO would lead to the disappearance of the state called Russian Federation from the world map.” Other op-eds are focused on European affairs; often scathing of Western leaders or emphasizing the growth of far-left and far-right groups in the West.

The site worked to give a platform to fringe academics and thinkers, while also nudging Western readers skeptical of mainstream political institutions towards Moscow’s worldview, Osadchuk said.

“The Kremlin propaganda machine has different target audiences. They have their own citizens … (but) at the same time they need to find allies abroad,” he added. “This is where Dugina comes in.”

Facebook said it had removed UWI from the platform in September 2020, after it received information from the FBI about its activity on other parts of the web.
“The people behind this activity attempted to conceal their identity and coordination,” a Facebook statement said, adding that its probe had uncovered links to people previously involved with the Russian Internet Research Agency (IRA), a notorious Russian troll farm known for meddling in the 2016 presidential election.
Following Russia’s invasion of Ukraine, Dugina was also sanctioned by the US and the United Kingdom, along with her father, for her involvement with UWI. The UK government concluded that she was a “frequent and high-profile contributor of disinformation in relation to Ukraine and the Russian invasion of Ukraine on various online platforms,” and therefore “provided support for and promoted policies or actions which destabilise Ukraine or undermine or threaten (its) territorial integrity, sovereignty or independence.”

But UWI remains accessible across the internet, frequently posting Russian-friendly opinion articles on foreign affairs. Its website made no mention of its chief editor’s death in the days following the explosion, despite the event dominating global and Russian news channels, nor has it ever acknowledged Dugina or her position on the site.

UWI’s reach is decidedly middling; it had around 5,000 followers each on Facebook and Instagram before being banned, while a cached version of its also-banned Twitter account had around 6,800 followers. (A new account which posts articles from the site is still live and has about 4,200 followers).

“The problem is that it always could be cascading,” Osadchuk said. “Even if the website itself isn’t that influential, it still provides the ideas and the platform for others to cite it as a credible source.”

Russia’s ‘disarming’ young activists in Europe

Websites like Dugina’s are not uncommon, according to Olga Lautman, a senior fellow at the Washington-based Center for European Policy Analysis (CEPA), who labeled their output “extremely important” to Russia’s soft power objectives.

“It’s a very systemic method … you will see all these sites pumping out the same identical message, the same talking points,” she said.

“The reader reads it in their language, they’re comfortable reading it, but they’re not necessarily sure where the information is stemming from,” Lautman added. “The whole point on a bigger scale is to shift the balance of power from the United States to Russia, and to allow the rise of authoritarianism and the subversion of democracy.”

Dugina’s interest extended beyond Russia and Ukraine; her website and talks frequently focused on elections across Europe, and in 2017 she was particularly involved in promoting far-right French presidential candidate Marine Le Pen

In a public appearance before the first vote round of voting in 2017, Dugina told a Moscow crowd during a talk that Le Pen was a “leader for the people” while criticizing eventual winner Emmanuel Macron, according to a write-up by nationalist Russian group Rodina.
The fringes of European politics were a space Dugina shared with a number of other young Russian activists and provocateurs, including Maria Katasonova — a content creator who set up an online “Women for Marine” movement and greeted Le Pen when she visited Moscow to meet Putin in 2017.

And Lautman suggests it is no coincidence that young women often find themselves on the frontlines of the global information war. “Russia has always known to use women as operatives,” she said. “Women happen to appeal to a bigger crowd … “they are more disarming, (in the case of Dugina and Katasonova) they are younger, they can relate to the younger population.”

“I can’t picture a group of 20-, 30-year-olds hanging on every word of (Alexander) Dugin, whereas Dugina is more energetic and can engage more with that age group.”

The domestic front

At home, the fruits of Russia’s communications campaign are pumped into living rooms via TV sets every evening on a scale that vastly dwarfs the output of younger, largely digital activists like Dugina.

State media spin-doctors such as Vladimir Solovyov, a popular talk-show host singled out by the US State Department as perhaps being the Russian government’s “most energetic” propagandist, figure prominently in the Kremlin’s information war.

But that effort, too, is frequently helmed by prominent female personalities, experts note, many of whom rushed to pay tribute to Dugina and called for harsh retaliation against Ukraine for her death, despite Kyiv’s repeated denials that it was involved in her murder.

Lautman pointed to several high-profile women at the top of Russia’s news and media apparatus — starting with Margarita Simonyan, the editor-in-chief of state TV channel RT (formerly Russia Today), which was banned from broadcasting in several Western countries following Moscow’s invasion.

Following Dugina’s death, Simonyan said on her Telegram channel that Russia should target “Decision Centers!” in Ukraine.

A January report by the US State Department outlined “close ties between Russian government officials and RT” and concluded that “on RT’s television shows, disinformation and propaganda that makes the Kremlin look good (and its perceived adversaries look bad) is repeatedly stated as fact.”

Simonyan herself has been front and center during many of the Kremlin’s spats with Western powers. She conducted the much-derided interview with the two men identified by the British government as suspects in the 2018 poisoning of Sergei and Yulia Skripal, in which the men claimed they were merely visiting the English city of Salisbury to admire the cathedral and its tall spire.

After Russia’s government claimed to have identified Dugina’s killer and said the person responsible had fled to Estonia, Simonyan appeared to reference what the two Salisbury suspects told her — joking on Twitter that Russia has professionals who “want to admire the spires near Tallinn.”

Lautman described the media empire that Simonyan oversees as “very influential,” particularly in appealing to older viewers nostalgic for the former Soviet Union.

Simonyan told Time magazine in 2015 that she has a yellow telephone on her desk with a direct line to the Kremlin, which is installed “to discuss secret things.” “There is no objectivity,” she told Russian newspaper Kommersant in 2012. “When Russia is at war, we are, of course, on the side of Russia.”
The heavily slanted, jingoistic world of Russian state-run TV is perhaps most forcefully occupied by Olga Skabeyeva, a firebrand TV presenter who regularly calls for dramatic escalations in Russian attacks on Ukraine and has urged Moscow to “demilitarize all of NATO too.”
She has elsewhere said that the rise in the LGBTQ+ population in the West will ultimately mean “people will run out” in the West as they “stop reproducing,” and has said Russia will “have to de-nazify ‘trans-fascists’ too,” according to clips compiled by BBC Monitoring correspondent Francis Scarr. During Europe’s recent heatwave, she said “nature is on Russia’s side too!”

“Their role is specifically to push Kremlin talking points for (Russians),” Lautman said. “Whatever it is, that’s what they will repeat from morning to night.”

Often, those talking points will first be sounded by Russian Foreign Ministry spokeswoman Maria Zakharova, who frequently issues fierce statements attacking Western countries alongside the Foreign Minister Sergey Lavrov.

“They want to make sure to cover everyone; Lavrov will appeal to some generational older men (but) they have someone for every crowd, and having her as a press secretary is powerful,” said Lautman. “Here you have this younger woman who’s taking on these (Western) powers, and isn’t afraid of challenging them.”

Though Dugina and many other women in Russia’s misinformation machine operate on dramatically different levels and in contrasting spheres, “they definitely look at each other as examples of what and how they could actually work on this,” Osadchuk said.

Dugina’s death has shone a light on one aspect of this operation. “They are doing this task differently,” he said. “(But) they are different parts of the same body.”

CNN’s Eliza Mackintosh contributed to this article.



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Study of ancient skulls sheds light on human interbreeding with Neandertals

Homo neanderthalensis adult male. Reconstruction based on Shanidar 1 by John Gurche for the Human Origins Program, NMNH. Credit: Chip Clark.

Research has established that there are traces of Neandertal DNA in the genome of modern humans. Now an exploratory study that assessed the facial structure of prehistoric skulls is offering new insights, and supports the hypothesis that much of this interbreeding took place in the Near East—the region ranging from North Africa to Iraq.

“Ancient DNA caused a revolution in how we think about human evolution,” says Steven Churchill, co-author of the study and a professor of evolutionary anthropology at Duke University. “We often think of evolution as branches on a tree, and researchers have spent a lot of time trying to trace back the path that led to us, Homo sapiens. But we’re now beginning to understand that it isn’t a tree—it’s more like a series of streams that converge and diverge at multiple points.”

“Our work here gives us a deeper understanding of where those streams came together,” says Ann Ross, corresponding author of the study and a professor of biological sciences at North Carolina State University.

“The picture is really complicated,” Churchill says. “We know there was interbreeding. Modern Asian populations seem to have more Neandertal DNA than modern European populations, which is weird—because Neandertals lived in what is now Europe. That has suggested that Neandertals interbred with what are now modern humans as our prehistoric ancestors left Africa, but before spreading to Asia. Our goal with this study was to see what additional light we could shed on this by assessing the facial structure of prehistoric humans and Neandertals.”

“By evaluating facial morphology, we can trace how populations moved and interacted over time,” Ross explains. “And the evidence shows us that the Near East was an important crossroads, both geographically and in the context of human evolution.”

For this study, the researchers collected data on craniofacial morphology from the published literature. This ultimately resulted in a data set including 13 Neandertals, 233 prehistoric Homo sapiens, and 83 modern humans.

The researchers focused on standard craniofacial measurements, which are reproducible, and used those measurements to assess the size and shape of key facial structures. This then allowed the researchers to do an in-depth analysis to determine whether a given human population was likely to have interbred with Neandertal populations, as well as the extent of that likely interbreeding.

“Neandertals had big faces,” Churchill says. “But size alone doesn’t establish any genetic link between a human population and Neandertal populations. Our work here involved a more robust analysis of the facial structures.”

The researchers also accounted for environmental variables that are associated with changes in human facial characteristics, to determine the likelihood that connections they established between Neandertal and human populations were the result of interbreeding rather than other factors.

“We found that the facial characteristics we focused on were not strongly influenced by climate, which made it easier to identify likely genetic influences,” Ross says. “We also found that facial shape was a more useful variable for tracking the influence of Neandertal interbreeding in human populations over time. Neandertals were just bigger than humans. Over time, the size of human faces became smaller, generations after they had bred with Neandertals. But the actual shape of some facial features retained evidence of interbreeding with Neandertals.”

“This was an exploratory study,” Churchill says. “And, honestly, I wasn’t sure this approach would actually work—we have a relatively small sample size, and we didn’t have as much data on facial structures as we would have liked. But, ultimately, the results we got are really compelling.

“To build on this, we’d like to incorporate measurements from more human populations, such as the Natufians, who lived more than 11,000 years ago on the Mediterranean in what is now Israel, Jordan and Syria.”

The paper is published in Biology.


The genomes of five late Neandertals provide insights into Neandertal population history


More information:
Steven E. Churchill et al, Midfacial Morphology and Neandertal–Modern Human Interbreeding, Biology (2022). DOI: 10.3390/biology11081163
Provided by
North Carolina State University

Citation:
Study of ancient skulls sheds light on human interbreeding with Neandertals (2022, August 23)
retrieved 23 August 2022
from https://phys.org/news/2022-08-ancient-skulls-human-interbreeding-neandertals.html

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Age Accelerating “Zombie Cells” – A New Study Sheds Light on These Unique Cells

Senescent cells, or “zombie cells,” are unique in that they ultimately cease multiplying but do not die off as expected.

Researchers have found a new pathway for the buildup of “zombie cells,” which promote aging.

Senescent cells, or cells that have lost their ability to divide, increase with age and are major contributors to age-related illnesses such as cancer, dementia, and cardiovascular disease. In a new study, a team led by the University of Pittsburgh and UPMC Hillman Cancer Center researchers discovered a method through which senescent, or “zombie,” cells develop.

Patricia Opresko, Ph.D., professor of environmental and occupational health and of pharmacology and chemical biology at the University of Pittsburgh and co-leader of the Genome Stability Program at UPMC Hillman Cancer Center. Credit: Patricia Opresko

The study, which was recently published in the journal Nature Structural & Molecular Biology, demonstrates for the first time that oxidative damage to telomeres — the protecting tips of chromosomes that behave like plastic caps at the end of a shoelace — can cause cellular senescence. These discoveries might ultimately result in new treatments that promote healthy aging or fight cancer.

“Zombie cells are still alive, but they can’t divide, so they don’t help replenish tissues,” said senior author Patricia Opresko, Ph.D., professor of environmental and occupational health and of pharmacology and chemical biology at Pitt. “Although zombie cells don’t function properly, they’re not couch potatoes — they actively secrete chemicals that promote inflammation and damage neighboring cells. Our study helps answer two big questions: How do senescent cells accumulate with age, and how do telomeres contribute to that?”

When a healthy human cell divides to create two identical cells, a little bit of

This hypothesis could not previously be tested since the techniques used to damage DNA were non-specific, creating lesions across the entire chromosome.

“Our new tool is like a molecular sniper,” explained first author Ryan Barnes, Ph.D., a postdoctoral fellow in Opresko’s lab. “It creates oxidative damage exclusively at the telomeres.”

X-shaped chromosomes are stained purple, and telomeres appear as green spots at chromosome tips. When researchers used a novel tool to induce oxidative damage specifically at telomeres, they can become fragile (green arrows), sending cells into senescence. The inset shows an enlarged chromosome with fragile telomeres, indicated by multiple green spots at chromosome tips. Credit: Barnes et al., Nature Structural & Molecular Biology, (2022)

To develop such marksman-like precision, the team used a special protein that binds exclusively to telomeres. This protein acts like a catcher’s mitt, grabbing hold of light-sensitive dye “baseballs” that the researchers tossed into the cell. When activated with light, the dye produces DNA-damaging reactive oxygen molecules. Because the dye-catching protein binds only to telomeres, the tool creates DNA lesions specifically at chromosome tips.

Ryan Barnes, Ph.D., a postdoctoral fellow at the University of Pittsburgh. Credit: Ryan Barnes

Using human cells grown in a dish, the researchers found that damage at telomeres sent the cells into a zombie state after just four days — much faster than the weeks or months of repeated cell divisions that it takes to induce senescence by telomere shortening in the lab.

“We found a new mechanism for inducing senescent cells that is completely dependent on telomeres,” explained Opresko, who also co-leads the Genome Stability Program at UPMC Hillman. “These findings also solve the puzzle of why dysfunctional telomeres are not always shorter than functional ones.”

Sunlight, alcohol, smoking, poor diet, and other factors generate reactive oxygen molecules that damage DNA. Cells have repair pathways to patch up DNA lesions, but, according to Opresko, telomeres are “exquisitely sensitive” to oxidative damage. The researchers found that damage at telomeres disrupted DNA replication and induced stress signaling pathways that led to senescence.

“Now that we understand this mechanism, we can start to test interventions to prevent senescence,” said Barnes. “For example, maybe there are ways to target antioxidants to the telomeres to protect them from oxidative damage.”

The findings could also inform the development of new drugs called senolytics that home in on zombie cells and kill them.

“By reducing the accumulation of zombie cells, which contribute to degenerative diseases, we might be able to promote ‘healthspan’ — the length of time that a person is healthy,” he added.

Reference: “Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening” by Ryan P. Barnes, Mariarosaria de Rosa, Sanjana A. Thosar, Ariana C. Detwiler, Vera Roginskaya, Bennett Van Houten, Marcel P. Bruchez, Jacob Stewart-Ornstein, and Patricia L. Opresko, 30 June 2022, Nature Structural & Molecular Biology.
DOI: 10.1038/s41594-022-00790-y



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Celtics center Al Horford sheds record for most playoff games played without Finals appearance

Al Horford postgame

Al Horford discusses his feelings after Boston’s Game 7 victory over Miami.

Al Horford is in The Finals after playing more postseason games prior to getting there than anyone in NBA history.

The Celtics’ veteran center had logged 141 playoff games without advancing past the conference finals, a league record finally broken after Boston’s Game 7 victory over Miami on Sunday.

When the final buzzer sounded, Horford was immediately overcome by the long-awaited moment. The 15-year veteran collapsed to the floor and screamed repeatedly, pounding the hardwood before rising to be embraced by Celtics teammates and staffers.

The five-time All-Star has missed the playoffs just twice since being drafted third overall by Atlanta in 2007, but came up one series short with the Hawks (once) and Celtics (twice) in his deepest postseason runs.

“It’s been a great journey,” Horford admitted. “Lot of battles. Obviously I’ve never been able to get it [until now], but a lot of great teammates along the way.”

Boston re-acquired Horford via trade last offseason, and the 35-year-old’s defense, size and leadership wound up being exactly what the franchise needed to return to The Finals for the first time since 2010.

“When he came back, it gave us a sense of security,” said Celtics guard Marcus Smart. “He’s selfless. Al couldn’t care less about the numbers. He cares about the wins and his team.”

“Nobody deserves it more than this guy on my right,” added Celtics forward Jaylen Brown. “I’m proud to be able to share this moment with a veteran, a mentor, a brother, a guy like Al Horford, man.”

In addition to shedding his own Finals-less streak, Horford also becomes the first player to represent the Dominican Republic in The Finals, a fact he enthusiastically celebrated while vacillating between Spanish and English when asked about the achievement.

“We’re here in Miami really close to D.R.,” Horford said. “I know my family’s happy. Everybody’s happy, everybody’s watching. The country was watching, I know everybody was there. They were sending me pictures. They were ready for this. We’re enjoying this one.”



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The moon’s near and far sides are surprisingly different. A new study sheds light on the mystery

The near side we are so familiar with appears darker in places — the result of the vast ancient lava flows, called lunar mare — while the far side is covered in pock marks and craters but no mare.

Why the two sides of the moon are so different has long puzzled space scientists. However, a study published last week in the journal Science Advances has come up with a new explanation for this lunar mystery.

The researchers found that the impact that formed the basin would have created a massive plume of heat that spread the moon’s interior, according to the statement. That plume would have carried certain materials to the moon’s nearside, fueling the volcanism that created the volcanic plains.

“We know that big impacts like the one that formed SPA would create a lot of heat,” said Matt Jones, a doctoral candidate at Brown University and the study’s lead author, in a news release.

“The question is how that heat affects the Moon’s interior dynamics. What we show is that under any plausible conditions at the time that SPA formed, it ends up concentrating these heat-producing elements on the nearside.

“We expect that this contributed to the mantle melting that produced the lava flows we see on the surface.”

The volcanic plains on the near side of the moon are home to a group of elements including potassium, rare earth elements, phosphorous among others — known as Procellarum KREEP terrane (PKT) that is rare elsewhere on the moon.

The researchers conducted computer simulations of how heat generated by a giant impact would alter patterns of heat transfer in the Moon’s interior, and how that might redistribute KREEP material in the lunar mantle.

According to their model, the KREEP material would have ridden the wave of heat emanating from the impact zone “like a surfer” whether the impact was a direct hit or just grazed the moon. As the heat plume spread beneath the moon’s crust, that material was eventually delivered to the nearside.

“How the PKT formed is arguably the most significant open question in lunar science,” Jones said in the news release.

“And the South Pole-Aitken impact is one of the most significant events in lunar history. This work brings those two things together, and I think our results are really exciting.”

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Discovery of matter-wave polaritons sheds new light on photonic quantum technologies

Nature Physics (2022). DOI: 10.1038/s41567-022-01565-4″ width=”800″ height=”530″/>
Experimental schematic and polariton formation. Credit: Nature Physics (2022). DOI: 10.1038/s41567-022-01565-4

The development of experimental platforms that advance the field of quantum science and technology (QIST) comes with a unique set of advantages and challenges common to any emergent technology. Researchers at Stony Brook University, led by Dominik Schneble, Ph.D., report the formation of matter-wave polaritons in an optical lattice, an experimental discovery that enables studies of a central QIST paradigm through direct quantum simulation using ultracold atoms. The researchers project that their novel quasiparticles, which mimic strongly interacting photons in materials and devices but circumvent some of the inherent challenges, will benefit the further development of QIST platforms that are poised to transform computing and communication technology.

The findings are detailed in a paper published in Nature Physics.

The research sheds light on fundamental polariton properties and related many-body phenomena, and it opens up novel possibilities for studies of polaritonic quantum matter.

An important challenge in work with photon-based QIST platforms is that while photons can be ideal carriers of quantum information they do not normally interact with each other. The absence of such interactions also inhibits the controlled exchange of quantum information between them. Scientists have found a way around this by coupling the photons to heavier excitations in materials, thus forming polaritons, chimera-like hybrids between light and matter. Collisions between these heavier quasiparticles then make it possible for the photons to effectively interact. This can enable the implementation of photon-based quantum gate operations and eventually of an entire QIST infrastructure.

However, a major challenge is the limited lifetime of these photon-based polaritons due to their radiative coupling to the environment, which leads to uncontrolled spontaneous decay and decoherence.

An artistic rendering of the research findings in the polariton study shows the atoms in an optical lattice forming an insulating phase (left); atoms turning into matter-wave polaritons via vacuum coupling mediated by microwave radiation represented by the green color (center); polaritons becoming mobile and forming a superfluid phase for strong vacuum coupling (right). Credit: Alfonso Lanuza/Schneble Lab/Stony Brook University.

According to Schneble and colleagues, their published polariton research circumvents such limitations caused by spontaneous decay completely. The photon aspects of their polaritons are entirely carried by atomic matter waves, for which such unwanted decay processes do not exist. This feature opens access to parameter regimes that are not, or not yet, accessible in photon-based polaritonic systems.

“The development of quantum mechanics has dominated the last century, and a ‘second quantum revolution’ toward the development of QIST and its applications is now well underway around the globe, including at corporations such as IBM, Google and Amazon,” says Schneble, a Professor in the Department of Physics and Astronomy in the College of Arts and Sciences. “Our work highlights some fundamental quantum mechanical effects that are of interest for emergent photonic quantum systems in QIST ranging from semiconductor nanophotonics to circuit quantum electrodynamics.”

The Stony Brook researchers conducted their experiments with a platform featuring ultracold atoms in an optical lattice, an egg-crate-like potential landscape formed by standing waves of light. Using a dedicated vacuum apparatus featuring various lasers and control fields and operating at nanokelvin temperature, they implemented a scenario in which the atoms trapped in the lattice “dress” themselves with clouds of vacuum excitations made of fragile, evanescent matter waves.

The team found that, as a result, the polaritonic particles become much more mobile. The researchers were able to directly probe their inner structure by gently shaking the lattice, thus accessing the contributions of the matter waves and the atomic lattice excitation. When left alone, the matter-wave polaritons hop through the lattice, interact with each other, and form stable phases of quasiparticle matter.

“With our experiment we performed a quantum simulation of an exciton-polariton system in a novel regime,” explains Schneble. “The quest to perform such ‘analogue’ simulations, which in addition are ‘analog’ in the sense that the relevant parameters can be freely dialed in, by itself constitutes an important direction within QIST.”

The Stony Brook research included graduate students Joonhyuk Kwon (currently a postdoc at Sandia National Laboratory), Youngshin Kim, and Alfonso Lanuza.


Enhanced interactions through strong light-matter coupling


More information:
Joonhyuk Kwon et al, Formation of matter-wave polaritons in an optical lattice, Nature Physics (2022). DOI: 10.1038/s41567-022-01565-4
Provided by
Stony Brook University

Citation:
Discovery of matter-wave polaritons sheds new light on photonic quantum technologies (2022, April 6)
retrieved 7 April 2022
from https://phys.org/news/2022-04-discovery-matter-wave-polaritons-photonic-quantum.html

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Long Covid sheds light on chronic illness: Meghan O’Rourke Q&A

Shortness of breath, heart palpitations, chest pain, fatigue and brain fog — those are just some of the ongoing complaints of a growing number of people, many of whom had only mild cases of acute Covid-19.

“Long Covid,” also known as post-acute sequelae of Covid-19, is associated with a whole host of problems involving multiple body systems, much like other chronic diseases that often go unrecognized and undiagnosed. Today, doctors and scientists are seeing epic spikes in immune dysregulation following Covid-19.

Estimates of the frequency of long-term symptoms and conditions after Covid-19 infection range from 5% to 80%, according to the US Centers for Disease Control and Prevention. The World Health Organization’s estimates range from 10% to 20%.

Whatever the final numbers, medical recognition of post-Covid conditions is driving new research into the long-term effects of infection. These findings, O’Rourke argued, could advance diagnosis and treatment of other chronic diseases as well.

This conversation has been edited and condensed for clarity.

CNN: How does Western medicine’s approach to disease impact people with chronic illness?

Meghan O’Rourke: Western medicine is very siloed — different kinds of doctors treat different parts of our bodies. This works well for acute care but not as well for chronic diseases that roam the body, as autoimmune diseases often do.

Systemic illnesses that produce a whole array of symptoms, say neurological problems combined with joint pain, require treatment from multiple doctors. Assimilating information from different providers and making sure your doctors are communicating can make it harder for patients to get comprehensive care.

Modern medicine is uncomfortable with treating problems it can’t easily see on X-rays, MRIs, echocardiograms or through lab work. Patients whose bodies exists at the edge of medical knowledge get left behind.

CNN: You mention that doctors tend to interrupt patients after 11 seconds of speech. What have you experienced?

O’Rourke: When you’re ill, you desperately want validation from others. Recognition gives you the possibility of treatment and even cure, but more importantly, the dignity of your reality.

In my 20s, I saw doctors for a roller coaster of symptoms, but no one ever thought I was sick. I got acutely ill in my mid-30s and was incapacitated for days on end. Initially, no doctor could find anything.

Loneliness came not just from missing out on life but from being alone with my illness.

Instead of doctors saying, “We don’t have the tools, yet, to see your disease,” they tend to assume symptoms are psychological and channel patients to a psychiatrist. That happened to me, too.

Medical science is based on doing no harm. But there’s a harm done by means of incuriosity when doctors reflexively categorize as psychological the symptoms of patients with hard-to-measure illnesses.

CNN: What impact does the “care effect” have on health?

O’Rourke: The “care effect” shows that patients treated by a doctor who is warm, asks questions and expresses empathy for your suffering show dramatic health improvements.
One study found that patients with irritable bowel syndrome treated by an empathetic versus a brusque researcher had symptom relief as high as that associated with the most powerful drugs.

Doctors need to get reimbursed for spending time with you and getting high empathy ratings.

CNN: What has helped you cope?

O’Rourke: I’ve spent a lot of time asking myself, how can I make this sickness a little more manageable? What are my goals for my life, my day, my morning, and how do I dispense my energy accordingly?

But validation must come first. You can’t get to that place of doing your own work until you’re not spending your energy just persuading people that what you’re dealing with is real.

Once you have that recognition, you’re faced daily with balancing what brings you joy within the limitations of your energy. I reminded myself often that I could own those tiny pockets of energy. Those were mine.

We love to tell other people how to be sick. But there’s no algorithm for it, no right answer. It’s different for every person and changes day by day.

CNN: What extra challenges do members of some communities face?

O’Rourke: I still remember the flush of shame and anger, followed by a wave of nausea, after a doctor had patronized me.

It became embodied for me in that moment that this was not just my story but that of tens of millions of Americans. If anything, I was having a good experience with chronic illness compared to many.

Privilege — financial, educational, geographical, language — plays a huge role in people’s experiences with these diseases, which require a huge amount of perseverance. Compounding the problem are structural racism and the lack of a social safety net that have tangible impacts on a person’s immune system.

Also, many doctors who understand these complex illnesses do not take insurance. They want to be free of the bureaucracies that limit time with patients to the 15-minute appointment.

CNN: What has the Covid-19 pandemic taught Western medicine about chronic illness?

O’Rourke: Covid has vividly dramatized the fact that infections can affect people in a wide variety of ways.

An emerging vanguard of medicine points to the idea that a lot of chronic illness is actually caused by repercussions of infection that affect a subset of patients who never fully recover.

Even before Covid, researchers were working to advance the idea that infection can trigger many kinds of chronic illnesses, including autoimmune disease, myalgic encephalomyelitis/chronic fatigue syndrome, or even chronic Lyme disease. Long Covid fits into this model.

CNN: How does long Covid manifest? What do you recommend for people suffering?

O’Rourke: Some patients report physical, neurological or cognitive symptoms. Evidence suggests that the immune response to Covid may impact your autonomic nervous system, triggering dysautonomia.

Many people with long Covid have documented postural orthostatic tachycardia syndrome, which affects blood flow. This can cause irregular blood pressure, fainting, dizziness, chest and abdominal pain, brain fog and even nausea. POTS is measurable, but doctors don’t routinely screen for it.
One piece of advice I give to any long Covid patient is that you actively ask for tests, including for dysautonomia and POTS, because they will not be given automatically.

Research also suggests that Covid can trigger food sensitivities, creating an immune response that would cause brain fog and fatigue.

Even patients who only had mild Covid cases can experience ongoing changes to breathing patterns that compromise both their nervous system and their blood oxygen levels. Targeted breathing exercises can help.
My overall recommendation is to keep searching for a really informed doctor, ideally one from a specialized unit like the Mount Sinai Center for Post-Covid Care. As with any multisystem chronic illness, coordinated care is best.

CNN: How has the prevalence of long Covid symptoms among health care workers shifted medicine’s view of these illnesses?

O’Rourke: Invisible diseases are more visible than ever.

Post-acute Covid syndrome will probably turn out to be an umbrella term for different kinds of diseases triggered by SARS-CoV-2. But long Covid is shining a light on a wide variety of chronic illnesses that all share immune and nervous system dysfunction.

The scope of the problem, now that so many people have been infected with Covid, has led to new research funding. The WHO, NIH (National Institutes for Health) and other places are dedicating new funds. But will these new research dollars be applied appropriately? Will patient’s voices and experiences be centered?

Some researchers are concerned about the ongoing tendency in Western medicine to sideline patients’ testimony.

Still, many researchers express hope that new attention and urgency around long Covid will lead to a sea change, improving diagnostics and treatments for a wide range of diseases.

Jessica DuLong is a Brooklyn-based journalist, book collaborator, writing coach and the author of “Saved at the Seawall: Stories from the September 11 Boat Lift” and “My River Chronicles: Rediscovering the Work that Built America.”

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Study sheds light on axion dark matter

Credit: CC0 Public Domain

Scientists from Durham University and Kings College London have presented a theoretical review in a new study strongly supporting the search for axion dark matter.

The identity of dark matter, which makes up 85% of the matter in the universe, is one of the big unanswered questions in particle physics.

Scientists know of its existence because of its gravitational pull effects on stars and galaxies but what kind of particle it is, still remains a mystery.

The researchers analyzed how axions can be described mathematically and presented how they relate to the fundamental symmetries of the Standard Model of particle physics.

The axion explains why the strong interaction—the force that binds together quarks in protons and neutrons—obeys time reversal symmetry. This means that, at the subatomic level, processes caused by the strong interaction would look the same if the direction of time was reversed.

Why the strong interaction obeys time reversal symmetry is still unknown. The axion is a popular solution to this mystery.

Axion dark matter behave more like a field covering the universe than like individual particles. In the early universe, the value of the axion field begins to oscillate back and forth. The energy stored in these oscillations is axion dark matter.

It is known that dark matter of any kind can only interact very weakly with light, or else it would have been seen by scientists already. Axion dark matter interacts with light very weakly, but by looking closely at telescope observations the researchers might be able to see signs of this interaction.

For example, a photon (a particle of light) traveling through a magnetic field would have a small probability of turning into an axion. This process would cause unusual features in telescope observations of galaxies shining through magnetic fields.

The full analysis of the study was published in Science Advances. A companion review paper—”Axion Dark Matter: How to see it?” by Yannis Semertzidis and SungWoo Youn—shows how the axion could be detected in the lab soon.

Study co-author, Dr. Francesca Chadha-Day, said: “It is a very exciting time to be an axion physicist. Nobody yet knows the identity of dark matter. By searching for different possibilities, such as the axion, we hope to one day solve this mystery.”

The researchers hope that this review will increase interest and understanding of axion physics within the broader community of physicists and scientists.


Using a Floquet quantum detector to constrain axion-like dark matter


More information:
Francesca Chadha-Day et al, Axion dark matter: What is it and why now?, Science Advances (2022). DOI: 10.1126/sciadv.abj3618. www.science.org/doi/10.1126/sciadv.abj3618

Yannis K. Semertzidis et al, Axion dark matter: How to see it?, Science Advances (2022). DOI: 10.1126/sciadv.abm9928. www.science.org/doi/10.1126/sciadv.abm9928

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Shock in France after giant trawler sheds 100,000 dead fish off coast | Fishing

Dutch-owned trawler FV Margiris, the world’s second-biggest fishing vessel, has shed more than 100,000 dead fish into the Atlantic Ocean off France.

France’s maritime minister, Annick Girardin, called the images of the dead fish – which formed a floating carpet of carcasses spotted by environmental campaigners – “shocking” and has asked the national fishing surveillance authority to launch an investigation.

Virginijus Sinkevicius, the European commissioner for environment, oceans and fisheries, also said he was seeking “exhaustive information and evidence about the case”.

France’s maritime minister, Annick Girardin, called the images of the dead fish ‘shocking’. Photograph: SEA SHEPHERD/AFP/Getty Images

The spill, which happened early on Thursday, was caused by a rupture in the trawler’s net, said fishing industry group the Pelagic Freezer-Trawler Association (PFA), which represents the vessel’s owner. In a statement, the group called the spill a “very rare occurrence”.

“In line with EU law, this has been recorded in the vessel’s log book and reported to the authorities of the vessel’s flag state, Lithuania,” it said. It added that the dead fish would be subtracted from the vessel’s quota.

The French arm of campaign group Sea Shepherd first published images of the spill, showing the ocean’s surface covered by a dense layer of blue whiting, a sub-species of cod, used to mass-produce fish fingers, fish oil and meal. It said the spill involved more than 100,000 fish and covered an area of about 3,000 sq m (32,300 sq ft).

The world’s second largest fishing vessel, the FV Margiris, released more than 100,000 dead whiting into the Atlantic. Photograph: Greenpeace/PA

Trawlers like the Margiris use drag nets more than a kilometre long and process the fish in onboard factories, a practice heavily criticised by environmentalists.

After protests by activists, the Margiris was forced to leave Australian waters in 2012. The vessel had a quota to haul 18,000 tonnes of fish from the sea but was banned by the then Labor environment minister Tony Burke following a public outcry.

Traffic data by marinetraffic.com on Friday showed the vessel, which is owned by the Dutch company Parleviliet & Van der Plas and sails under the flag of Lithuania, was still engaged in fishing activities off the French coast.

With Reuters

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