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Fly me to the moon, let me play among the stars: NASA will send your name around the moon

In this image provided by NASA, the United States of America is seen at night from a composite assembled from data acquired by the Suomi NPP satellite in April and October 2012. A NASA mission, the Artemis I, will see the uncrewed Orion spacecraft take off from the Kennedy Space Center in Florida and spend several days circling the moon before returning to earth. (NASA)

Estimated read time: 1-2 minutes

TORONTO, Ontario — Right now, you can sign up online to get a “boarding pass” for the Artemis I mission, which is expected to blast off and orbit the moon this May or June.

Every seat is free, in a way. Artemis I will be an uncrewed test flight for future lunar missions. Signing up with NASA gets your name added to a flash drive aboard the unoccupied ​crew capsule, and a flashy digital boarding pass as proof.

Powered by NASA’s most powerful rocket to date, the Space Launch System, the Artemis I mission will see the uncrewed Orion spacecraft take off from the Kennedy Space Center in Florida and spend several days circling the moon before returning to earth. If all goes according to plan, the Artemis 2 mission will perform a crewed lunar flyby in 2024.

The ultimate goal of the Artemis program is to put humans back on the moon by 2025, which is 53 years after the last crewed lunar mission, Apollo 17. In Greek mythology, Artemis fittingly is Apollo’s twin sister and the moon’s goddess.

As part of the program, NASA will land the first woman and the first person of color on the lunar surface, where it also plans to work with international and commercial partners to create a long-term human presence and use those lessons to take astronauts to Mars.

NASA has launched names before, like in 2020 when nearly 11 million names were installed on the Mars Perseverance rover, which continues to crawl around the red planet.

Signing up to put your name aboard Artemis I is quick and easy. As a bonus, you earn 1.3 million novelty miles, or 2.1 million km, which is the total distance the Artemis 1 mission will travel.

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Utah Legislature passes last-minute ban on transgender female athletes; Gov. says he’ll veto

Sen. Daniel McCay, R-Riverton, left, and Sen. Curt Bramble, R-Provo, speak in favor of HB 11, Student Eligibility in Interscholastic Activities, during the last evening of the Utah Legislature’s 2022 general session at the Capitol in Salt Lake City on Friday, March 4, 2022. McCay proposed an all-out ban on transgender female students participating on girls sports teams. (Laura Seitz, Deseret News)

Estimated read time: 7-8 minutes

SALT LAKE CITY — In the last few hours of the Utah Legislature on Friday night, a lawmaker proposed an all-out ban on transgender female students participating on girls sports teams.

The new version of the bill was a leap away from the original that sought to create a commission to determine eligibility of individual students.

The Senate passed the bill 16-13. The House then passed the bill 46-29 with its changes after a 15-minute debate.

But Gov. Spencer Cox said he’ll veto it immediately. The narrow vote margin in the Senate is unlikely to see a veto override.

“I was as stunned as most members of the Senate were,” Cox said. “Some of the worst decisions get made at the last minute.”

Last-minute proposal to ban students

On the Senate floor about 8:30 p.m., Sen. Dan McCay, R-Riverton, introduced his proposed ban and explained he believes finding a compromise on the issue “did not work out” and left some wondering “what we should do in the alternative.”

The new version of HB11 would put the ban in place and create a “springing trigger” that will come into play if a court stays the ban. If the state receives an injunction, the bill would initiate a “brilliant compromise” to create a commission to determine eligibility, McCay said.

He said he considered whether Utah should address the issue like 10 other states by putting “a ban in place,” calling the move a “pin in the debate … before we see an uptake of transgender females participating in sports.”

Society decided “long ago” to create a “lane” for women to compete in, the senator said.

“This debate, if nothing else, is at least bringing that issue to the forefront. As the father of four daughters, we’ve had this debate on several occasions. They all participate in sports in one way or another,” McCay said, adding that it’s been difficult for his family to find a balance on the issue.

McCay appeared to start crying as he said he feels it’s his “responsibility” to propose the changes.

“I’ve got to protect them,” McCay said of his daughters.

Bill co-sponsor Sen. Curt Bramble, R-Provo, noted the previous version of the bill the House worked on would set up a commission intended to evaluate the physiological characteristics of a transgender female athlete to determine whether they exceed the average performance of a female of a certain age.

But the bill as written contained a list of physical characteristics that would need to be evaluated, Bramble noted. Another version of the bill negotiated with LGBTQ advocates and other stakeholders would remove the list of characteristics and leave those decisions in the hands of the commission.

However, before the floor debate, Bramble said he would give up his time to present the bill to allow McCay to propose his version.

The debate is a continuation from last year, when bill sponsor Rep. Kera Birkeland, R-Morgan, proposed a ban on female transgender athletes. This year, she brought the idea of a commission after last year’s bill failed in the Senate.

‘Blindsided’

Sen. Gene Davis, D-Salt Lake City, called the proposal a “blindside to our side of the aisle.” He asked if the bill could be circled for the caucus to meet privately to discuss the bill.

Bramble opposed that request and said the state “needs to address” it now.

But Democratic lawmakers continued to plead for time to discuss the bill, contending they needed a chance to discuss it due to the extent of changes. Their request was not granted as the majority of Republican senators voted against letting them huddle.

Sen. Derek Kitchen, D-Salt Lake City, noted that the new proposal is a different bill than what was approved by the House and approved by a Senate committee. He questioned the process the bill went through.

In an emotional speech on the floor, Sen. Daniel Thatcher, R-West Valley City, said he’s “really disappointed” his colleagues wouldn’t give the minority caucus a chance to talk about the change.

He said he’s also disappointed about the message the new version of the bill will send to transgender kids.

“Kids who just want to be loved, who just want to be seen, who just want to live. I want them to know that I’m sorry that I couldn’t do more. I want them to know that we’re changing, and we are learning, and we are growing,” Thatcher said.

Thatcher urged any children who are struggling to download the SafeUT app — a statewide resource for mental health help — immediately if they need to.

“Because we need you, and it will get better. … And I’m sorry for what’s about to happen,” Thatcher said.

Sen. David Hinkins, R-Orangeville, compared the issue to the horse industry and said male horses don’t race against female horses.

“A jockey’s fine, I’d rather have a female jockey than a male jockey. But as far as running, I’d probably bet on the male,” Hinkins said.

Sen. Kathleen Riebe, R-Cottonwood Heights, said school districts across the state learned at 8:21 p.m., three hours before the end of the session, that they could face lawsuits should the bill pass.

But McCay said school districts would qualify for governmental immunity and not face liability. He acknowledged, however, that the ban would be expensive for the state to defend in court. The Utah High School Activities Association, a private entity, would not be indemnified in the bill and would need to retain its own representation in lawsuits.

Senate Minority Whip Luz Escamilla, D-Salt Lake City, questioned what will happen to girls who aren’t transgender but who are “outliers” in size and strength for their age if they get challenged about their gender. “What protection are we giving to those children and their families?” she asked.

Bramble said he doesn’t believe the bill would give parents the chance to challenge other children.

“You’re opening the door for children to be questioned based on their look, based on their size and strength,” Escamilla said.

Governor to veto bill

In a news conference immediately after the Senate vote, Cox told reporters he was “as stunned as most members of the Senate were” by the new version of the bill. He said an all-out ban was never a part of the conversations about the commission, and it was “incredibly disappointing” to see the bill changed so drastically in the final hours.

But Cox promised to immediately veto it as soon as it lands on his desk.

Asked about what he would say to transgender youth listening to the debate and any of the transphobic remarks on the Senate floor, Cox urged them to “just listen to (Thatcher’s) testimony and know that’s where I come from, as well.”

The governor, who has been an outspoken ally for the LGBTQ community, then teared up and added: “It’s going to be OK. We’re going to work through this. We’re going to find a good path, and there are a lot of people that really love and care about them.”

For those across the nation paying attention to how Utah lawmakers acted on the issue, Cox said it’s an issue that other states across the nation have grappled with, and Utah is “trying to figure this out, too.”

“Have some patience with us,” he said.

Earlier Friday before McCay’s version of the bill had been released, Cox voiced his support for the commission version of the bill without the list of physical characteristics, which he described as “offensive.”

He said those working on the bill promised they would make those changes.

“No one’s going to be happy with this bill, no one on either side is going to be happy with this bill. I recognize that. What we’re trying to do is something very unique and very special. Can we find another way instead of just saying nobody gets to participate? And I think we can, and I want to try,” Cox said.

Last year, the governor said he would veto the bill that sought to ban transgender females should it pass.

The new version of the bill drew the ire of LGBTQ advocates.

“A last-minute substitute has changed HB11 into an outright ban against transgender youth playing sports. It is an entirely new bill that scraps the months of negotiation among many interested parties. This is not the #UT way to create legislation. #utleg #utpol,” ACLU of Utah tweeted.

Contributing: Katie McKellar

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Utah Legislature passes last-minute ban on transgender female athletes; Gov. says he’ll veto

Sen. Daniel McCay, R-Riverton, left, and Sen. Curt Bramble, R-Provo, speak in favor of HB 11, Student Eligibility in Interscholastic Activities, during the last evening of the Utah Legislature’s 2022 general session at the Capitol in Salt Lake City on Friday, March 4, 2022. McCay proposed an all-out ban on transgender female students participating on girls sports teams. (Laura Seitz, Deseret News)

Estimated read time: 7-8 minutes

SALT LAKE CITY — In the last few hours of the Utah Legislature on Friday night, a lawmaker proposed an all-out ban on transgender female students participating on girls sports teams.

The new version of the bill was a leap away from the original that sought to create a commission to determine eligibility of individual students.

The Senate passed the bill 16-13. The House then passed the bill 46-29 with its changes after a 15-minute debate.

But Gov. Spencer Cox said he’ll veto it immediately. The narrow vote margin in the Senate is unlikely to see a veto override.

“I was as stunned as most members of the Senate were,” Cox said. “Some of the worst decisions get made at the last minute.”

Last-minute proposal to ban students

On the Senate floor about 8:30 p.m., Sen. Dan McCay, R-Riverton, introduced his proposed ban and explained he believes finding a compromise on the issue “did not work out” and left some wondering “what we should do in the alternative.”

The new version of HB11 would put the ban in place and create a “springing trigger” that will come into play if a court stays the ban. If the state receives an injunction, the bill would initiate a “brilliant compromise” to create a commission to determine eligibility, McCay said.

He said he considered whether Utah should address the issue like 10 other states by putting “a ban in place,” calling the move a “pin in the debate … before we see an uptake of transgender females participating in sports.”

Society decided “long ago” to create a “lane” for women to compete in, the senator said.

“This debate, if nothing else, is at least bringing that issue to the forefront. As the father of four daughters, we’ve had this debate on several occasions. They all participate in sports in one way or another,” McCay said, adding that it’s been difficult for his family to find a balance on the issue.

McCay appeared to start crying as he said he feels it’s his “responsibility” to propose the changes.

“I’ve got to protect them,” McCay said of his daughters.

Bill co-sponsor Sen. Curt Bramble, R-Provo, noted the previous version of the bill the House worked on would set up a commission intended to evaluate the physiological characteristics of a transgender female athlete to determine whether they exceed the average performance of a female of a certain age.

But the bill as written contained a list of physical characteristics that would need to be evaluated, Bramble noted. Another version of the bill negotiated with LGBTQ advocates and other stakeholders would remove the list of characteristics and leave those decisions in the hands of the commission.

However, before the floor debate, Bramble said he would give up his time to present the bill to allow McCay to propose his version.

The debate is a continuation from last year, when bill sponsor Rep. Kera Birkeland, R-Morgan, proposed a ban on female transgender athletes. This year, she brought the idea of a commission after last year’s bill failed in the Senate.

‘Blindsided’

Sen. Gene Davis, D-Salt Lake City, called the proposal a “blindside to our side of the aisle.” He asked if the bill could be circled for the caucus to meet privately to discuss the bill.

Bramble opposed that request and said the state “needs to address” it now.

But Democratic lawmakers continued to plead for time to discuss the bill, contending they needed a chance to discuss it due to the extent of changes. Their request was not granted as the majority of Republican senators voted against letting them huddle.

Sen. Derek Kitchen, D-Salt Lake City, noted that the new proposal is a different bill than what was approved by the House and approved by a Senate committee. He questioned the process the bill went through.

In an emotional speech on the floor, Sen. Daniel Thatcher, R-West Valley City, said he’s “really disappointed” his colleagues wouldn’t give the minority caucus a chance to talk about the change.

He said he’s also disappointed about the message the new version of the bill will send to transgender kids.

“Kids who just want to be loved, who just want to be seen, who just want to live. I want them to know that I’m sorry that I couldn’t do more. I want them to know that we’re changing, and we are learning, and we are growing,” Thatcher said.

Thatcher urged any children who are struggling to download the SafeUT app — a statewide resource for mental health help — immediately if they need to.

“Because we need you, and it will get better. … And I’m sorry for what’s about to happen,” Thatcher said.

Sen. David Hinkins, R-Orangeville, compared the issue to the horse industry and said male horses don’t race against female horses.

“A jockey’s fine, I’d rather have a female jockey than a male jockey. But as far as running, I’d probably bet on the male,” Hinkins said.

Sen. Kathleen Riebe, R-Cottonwood Heights, said school districts across the state learned at 8:21 p.m., three hours before the end of the session, that they could face lawsuits should the bill pass.

But McCay said school districts would qualify for governmental immunity and not face liability. He acknowledged, however, that the ban would be expensive for the state to defend in court. The Utah High School Activities Association, a private entity, would not be indemnified in the bill and would need to retain its own representation in lawsuits.

Senate Minority Whip Luz Escamilla, D-Salt Lake City, questioned what will happen to girls who aren’t transgender but who are “outliers” in size and strength for their age if they get challenged about their gender. “What protection are we giving to those children and their families?” she asked.

Bramble said he doesn’t believe the bill would give parents the chance to challenge other children.

“You’re opening the door for children to be questioned based on their look, based on their size and strength,” Escamilla said.

Governor to veto bill

In a news conference immediately after the Senate vote, Cox told reporters he was “as stunned as most members of the Senate were” by the new version of the bill. He said an all-out ban was never a part of the conversations about the commission, and it was “incredibly disappointing” to see the bill changed so drastically in the final hours.

But Cox promised to immediately veto it as soon as it lands on his desk.

Asked about what he would say to transgender youth listening to the debate and any of the transphobic remarks on the Senate floor, Cox urged them to “just listen to (Thatcher’s) testimony and know that’s where I come from, as well.”

The governor, who has been an outspoken ally for the LGBTQ community, then teared up and added: “It’s going to be OK. We’re going to work through this. We’re going to find a good path, and there are a lot of people that really love and care about them.”

For those across the nation paying attention to how Utah lawmakers acted on the issue, Cox said it’s an issue that other states across the nation have grappled with, and Utah is “trying to figure this out, too.”

“Have some patience with us,” he said.

Earlier Friday before McCay’s version of the bill had been released, Cox voiced his support for the commission version of the bill without the list of physical characteristics, which he described as “offensive.”

He said those working on the bill promised they would make those changes.

“No one’s going to be happy with this bill, no one on either side is going to be happy with this bill. I recognize that. What we’re trying to do is something very unique and very special. Can we find another way instead of just saying nobody gets to participate? And I think we can, and I want to try,” Cox said.

Last year, the governor said he would veto the bill that sought to ban transgender females should it pass.

The new version of the bill drew the ire of LGBTQ advocates.

“A last-minute substitute has changed HB11 into an outright ban against transgender youth playing sports. It is an entirely new bill that scraps the months of negotiation among many interested parties. This is not the #UT way to create legislation. #utleg #utpol,” ACLU of Utah tweeted.

Contributing: Katie McKellar

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Conflict in Ukraine pushes mortgage rates lower

The 30-year fixed-rate mortgage averaged 3.76% in the week ending March 3, down from 3.89% the week before, according to Freddie Mac.

Rates fell as a result of receding US Treasury yields this week, as investors moved to the safety of bonds due to growing tensions between Russia and Ukraine, said Sam Khater, Freddie Mac’s chief economist.

“While inflationary pressures remain, the cascading impacts of the war in Ukraine have created market uncertainty,” Khater said. “Consequently, rates are expected to stay low in the short-term, but will likely increase in the coming months.”

Experts and analysts had forecasted a fairly steady rise for mortgage rates this year, but Russia’s invasion of Ukraine followed by severe economic sanctions has created uncertainty.

“Investors are concerned about the deepening Russia-Ukraine conflict and rising oil prices, and are wary of spillover effects from rising economic sanctions,” said George Ratiu, Realtor.com’s manager of economic research.

He said that markets have their eyes on mounting inflation and an expectation that the Federal Reserve will proceed with a 25-basis-point hike at its upcoming meeting later this month.

“Market volatility and rising oil prices are likely to push bond yields into larger swings, while inflation will keep upward pressure on mortgage rates,” Ratiu said.

Mortgage applications are falling

Mortgage applications decreased during the last full week of February, according to the Mortgage Bankers Association, partially in response to climbing rates.

Applications for loans to purchase a home remained weak, said Joel Kan, MBA’s associate vice president of economic and industry forecasting. Meanwhile, the average loan size increased again — to a new record of $454,400 — an indication that home prices are still rising and a greater share of mortgage activity is occurring at the higher end of the market, he said.

“We will continue to assess the potential impact on mortgage demand from the sharp drop in interest rates this week due to the invasion of Ukraine,” he said.

Meanwhile, Ratiu said, real estate markets are seeing an early start to the spring buying season, with unseasonably high demand and record low inventory continuing to push home prices higher.

“At today’s rate, the buyer of a median-priced home will pay over $278 per month more than a year ago on their mortgage payment,” Ratiu said. “Surging prices and higher rates are creating challenges for first-time buyers looking for a home, causing them to make difficult choices in light of higher monthly costs for food, gasoline, clothing, cars and health care.”

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Fewer colonoscopies during pandemic has led to cancer increase, Utah doctors say

A polyp is discovered during a colonoscopy at St. Marks Hospital in this March 22, 2011 photo. Doctors from Intermountain Healthcare on Wednesday encouraged people to schedule a colonoscopy, particularly since the pandemic has led to a big drop in screenings. (Laura Seitz, Deseret News)

Estimated read time: 4-5 minutes

SALT LAKE CITY — Colonoscopies have a bad reputation, partially because of the preparation patients need to do before the procedure. But two Utah doctors emphasized Wednesday how they play an important role in preventing later-stage cancer and can save lives.

Dr. Nathan Merriman, an Intermountain Healthcare gastroenterologist, said he has seen a lot of hesitance from patients needing colonoscopy screenings, especially over the last two years. He has seen a 50% drop in screening colonoscopies during the COVID-19 pandemic.

March is Colorectal Cancer Awareness Month, and Merriman is encouraging people to take time now to schedule screenings or diagnostic colonoscopies and talk to family members about the issue.

In the United States, colorectal cancer is the second-leading cause of death from cancer, and the third-leading cause for both men and women separately. It’s expected to cause over 50,000 deaths in the country this year.

Since the onset of COVID-19, there has been a 15% increase in stage 3 colon cancer, which is advanced enough that it will almost always be treated with chemotherapy, according to Dr. Mark Lewis, an oncologist. One of the causes for this could be delayed colonoscopies due to the pandemic.

Lewis said colon cancer is largely preventable, and with early intervention people will never need to go see an oncologist like him.

“I never want to give chemo. I mean, no oncologist, frankly, wants to give chemo. We’re actually actively trying to give less of it,” he said.

Lewis said that it has never been more important to catch cancer earlier and minimize the risk for chemotherapy than during the pandemic because chemotherapy can weaken the immune system and make it more likely for someone to contract COVID-19 along with other illnesses.

Screenings for colon cancer have fallen behind other cancer screenings, he said, although they are very effective. A colonoscopy doesn’t just find polyps, small tissue bumps that can become cancerous, but they can also be removed during the procedure.

Merriman said it is important to talk with family members about patterns of illness and disease in the family, specifying if there is a history of cancer or polyps. Smoking is also a risk factor for colon cancer.

“We can do so much more to help each other, especially at the family level, to understand what we’re at risk for,” he said.

It is currently recommended that anyone who is 45 gets screened for colorectal cancer, which was lowered from age 50 in the last few years. Those with a family history of colon cancer should begin screenings 10 years before the age that their relative was diagnosed. People who have bowel diseases or polyps, or a family history of either, should also be screened before the age of 45, Merriman said.

He encouraged people to ask a doctor if they are wondering if they should get a colonoscopy. He said the preparation process for a colonoscopy is “tolerable, not terrible,” and has become a lot better over the last 10 years, and is continuing to improve.

Signs that someone has colon cancer can include changes in the shape of stool, abdominal pain that could cause weight loss and bloody stools.

Lewis and Merriman both said they have seen multiple patients who have encountered rectal bleeding for multiple months but waited to talk to a doctor. They said if this is persistent, a patient should get a colonoscopy and be checked for colon cancer.

“We won’t know if there are symptoms going on unless (patients) feel comfortable speaking up, and we empower them to speak up … then we can learn from our patients and help them to get the care they need,” Merriman said.

He said he chose to go into gastroenterology because of an unrelated loss in his life that was preventable, and he hopes to help prevent tragedies for others.

“We have this amazing ability to help prevent suffering by identifying polyps in the colon, removing them and preventing the whole cascade of cancer that is hard, so hard, on patients and their families,” Merriman said.

Lewis said that he came to Utah because it is the youngest state and there is a particular problem with early-onset colorectal cancer in the state.

People need to be more comfortable talking about colonoscopies and cancer, he said, adding that he sees a lot of people with guilt or who put pressure on themselves after a diagnosis. Although there are prevention steps, like colonoscopies, colon cancer is not always preventable. Lewis said some polyps can take 10 years to become cancerous, while others become cancerous very quickly.

Although they recommend screening at age 45, Lewis said that depending on how the screening goes some patients may not need another screening for years, while others may require follow-ups much sooner.

“Each patient’s treatment is then tailored to them so it is not one size fits all. Once you get into the screening process it looks a little bit different for everybody,” Lewis said.

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Dementia linked to premature menopause for women, study says

Entering menopause before age 40 is linked to a 35% higher risk of developing dementia later in life, a preliminary study finds. (Viacheslav Iakobchuk, Alamy)

Estimated read time: 4-5 minutes

WASHINGTON — Entering menopause before age 40 is linked to a 35% higher risk of developing dementia later in life, a preliminary study finds.

Premature menopause, as it is called, occurs when a woman’s ovaries stop creating hormones and the menstrual cycle ends by age 40. That’s about a dozen years earlier than the typical onset of menopause, which is age 52 in the United States, according to the U.S. Department of Health and Human Service’s Office on Women’s Health.

“What we see in this study is a modest association between premature menopause and a subsequent risk for dementia,” said Dr. Donald Lloyd-Jones, president of the American Heart Association. He was not involved in the study.

Why do women go through premature menopause? Unless the woman has had surgery to remove her ovaries and uterus, “it has to do with a more rapid biological aging of all of the body’s tissues, including premature aging of our organs and their function,” said Lloyd-Jones, who is a professor of preventive medicine, medicine and pediatrics at Northwestern University’s Feinberg School of Medicine in Chicago.

“It’s a red flag on many levels when a woman goes through premature menopause, as it indicates there may be some underlying genetic, environmental or health behavior issues that we really need to focus on,” he added.

Menopause before age 45

The study, which is not published but will be presented this week at the American Heart Association’s 2022 conference, examined data on over 153,000 women who participated in the UK Biobank, an ongoing study that examines genetic and health information on a half million people living in the United Kingdom.

“The scope and breadth of the data is important and impressive, but it doesn’t give us the details we need to understand the study’s full implications,” Lloyd-Jones said.

The study adjusted for age, race, weight, educational and income level, cigarette and alcohol use, cardiovascular disease, diabetes and physical activities. It found that women who became menopausal before the age of 45 were 1.3 times more likely to be diagnosed with early dementia by age 65.

Early menopause, which occurs between age 40 and 45, is categorized separately from premature menopause before age 40, but both can be caused by many of the same factors: a family history; autoimmune disorders, including chronic fatigue syndrome; HIV and AIDS; chemotherapy or pelvic radiation treatments for cancer; surgery to remove the ovaries and uterus; and smoking.

“Functional menopause due to surgery is less risky than biological menopause occurring early, as again it may be a red flag that other tissues are aging more rapidly, so a woman needs to really get with her doctor and have a plan to optimize all of her health factors,” Lloyd-Jones said.

Role of estrogen?

When women enter menopause, estrogen levels plummet, which may be one reason for the study’s findings, said study author Wenting Hao, a doctoral candidate at Shandong University in Jinan, China.

“We know that the lack of estrogen over the long term enhances oxidative stress, which may increase brain aging and lead to cognitive impairment,” Hao said in a statement.

Oxidative stress occurs when the body’s antioxidant defenses can’t keep up with an overabundance of radicals, or unstable atoms that can damage cells. Free radicals occur naturally in the body as a byproduct of cell metabolism, but levels can be raised by exposure to smoking, environmental toxins, pesticides, dyes and air pollution.

“However, I think premature menopause is a more significant signal than just being about estrogen,” Lloyd-Jones said. “Just as gestational diabetes or preeclampsia should be a sign, premature menopause says this is a woman who is on the faster track to having a problem with her heart or her brain.

“Let’s control everything else we can control about her diet, physical activity, weight and smoking with lifestyle changes and if needed, medication,” Lloyd-Jones added.

There are a number of ways women who experience early menopause may be able to reduce their risk of cognitive decline, Hao said.

“This includes routine exercise, participation in leisure and educational activities, not smoking and not drinking alcohol (and) maintaining a healthy weight,” Hao said. “Being aware of this increased risk can help women practice strategies to prevent dementia and to work with their physicians to closely monitor their cognitive status as they age.”

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Utah researchers see ‘exciting’ results treating opioid addiction with ‘mindfulness’

A new University of Utah clinical trial shows that something called mindfulness therapy can decrease misuse of opioids and decrease chronic pain symptoms, opioid cravings and symptoms of depression. (Mark Lennihan, Associated Press)

Estimated read time: 4-5 minutes

SALT LAKE CITY — A University of Utah clinical trial suggests that “mindfulness” is useful in decreasing opioid misuse and reducing symptoms of chronic pain.

The trial evaluated an eight-week mindfulness-based therapy program known as MORE — Mindfulness-Oriented Recovery Enhancement.

This was the first large-scale clinical trial to demonstrate that psychological interventions can reduce opioid misuse among those who are prescribed opioids to manage chronic pain.

“MORE demonstrated one of the most powerful treatment effects I’ve seen,” said Eric Garland, lead author of the study. “There’s nothing else out there that works this well in alleviating pain and curbing opioid misuse.”

The therapy teaches participants to break down their pain experience and opioid craving into different components — like heat, tightness and tingling — and notice how these change over time. It also teaches them to savor positive everyday experiences and to reframe stressful events to recognize learning.

“Rather than getting caught up in the pain or craving,” Garland explained, “we teach people how to step back and observe that experience from the perspective of an objective witness. When they can do that, people begin to recognize that who they truly are is bigger than any one thought or sensation. They are not defined by their experiences of pain or craving; their true nature is something more.”

Garland is the associate dean for research at the University of Utah College of Social Work and directs the Center on Mindfulness and Integrative Health Intervention Development. He is a leader in the academic field of mindfulness research.

He said that the data from the study definitively shows that this therapy is effective for chronic pain and opioid misuse. They expected the therapy to prove helpful, but Garland said he was surprised by how powerful the effect of the therapy was on the individuals in the trial.

Garland said that the effects of Mindfulness-Oriented Recovery Enhancement appear to get stronger over time, which could be attributed to people integrating the mindfulness skills they learn into their lives or their brains restructuring how they process rewards so they value healthy rewards more.

The trial saw the effects of the program grow for nine months after the study. Garland said that was as far as the funding allowed them to track progress, but he expects the trend will continue.

The study, which was published in the Journal of the American Medical Association, followed 250 adults with chronic pain who were on opioid therapy, primarily taking oxycodone or hydrocodone. Over half of them had a diagnosable opioid use disorder.

After the therapy, which included weekly two-hour group therapy sessions and 15 minutes of homework each day, 45% of participants reported they were no longer misusing opioids, 36% reported they had cut opioid use in half or more.

“Patients in MORE had more than twice the odds of those in standard psychotherapy to stop misusing opioids by the end of the study. Additionally, participants in the MORE group reported clinically significant improvements in chronic pain symptoms, decreased opioid craving and reduced symptoms of depression to levels below the threshold for major depressive disorder,” the University of Utah press release states.

One reason this approach has been successful is it addresses pain and opioid use simultaneously, which is significant because opioid misuse has been shown to increase pain sensitivity, causing further misuse.

According to Garland, the therapy reduces physical pain, emotional pain from depression or post-traumatic stress disorder, along with the addictive behavior. He said at the beginning of the study, almost 70% of participants met the criteria for major depression. But on average, they did not show the same symptoms after treatment.

“You can use one single intervention to simultaneously help with all of these problems, that’s what’s really exciting to me,” Garland said.

He said that Mindfulness-Oriented Recovery Enhancement has primarily been used to study opioid misuse and chronic pain, but that they have also done smaller-scale studies on its use in treating other addictive behaviors, including alcohol, drugs, cigarettes and video games. They have also considered using it for helping with weight loss.

This five-year clinical study was funded by a $2.8 million grant from the National Institute on Drug Abuse.

Garland said now that it has been proven that the mindfulness program is effective, he hopes that they are able to help more people access the therapy, which will involve training for therapists, social workers, psychologists, nurses, doctors and health care systems.

He said he hopes money that Utah will soon be receiving from a settlement with opioid companies will help fund this effort, as it is one of the most effective therapies for treating opioid addiction.

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Parents are desperate after baby formula recall wipes out supply

Elizabeth Coco’s son Thomas is dependent on Elecare for his nutritional needs. Families all over the country are in a race against the clock to find a critical source of food they desperately need to keep their children fed — baby formula.
(Elizabeth Coco via CNN)

Estimated read time: 6-7 minutes

ATLANTA — It’s a nightmare no parent ever wants to endure.

Families all over the country are in a race against the clock to find a critical source of food they desperately need to keep their children fed — baby formula.

For months, stores nationwide have struggled to stock enough baby formula. Manufacturers say they’re producing at full capacity and are making more formula than ever before, but it’s still not enough to meet current demand.

Then came last week’s gut punch that made matters worse and left parents like Sarah Ellis reeling.

The U.S. Food and Drug Administration last Thursday recalled three brands of powdered baby formulas due to potential bacterial infections, including salmonella. The agency advised parents not to buy or use certain batches of Similac, Alimentum and EleCare powdered infant formulas. All three brands are made by Abbott Nutrition.

Both Alimentum and EleCare are specialized formulas. Alimentum is hypoallergenic and easier to digest for infants with a lactose sensitivity or an allergy to cow’s milk protein. EleCare, also a hypoallergenic formula without milk or lactose-based ingredients, is given to infants and older children with severe food allergies, gastrointestinal disorders and other conditions that may require oral or tube feeding.

Before the recall, Ellis was already struggling to find enough supply of EleCare for her almost 4-year-old daughter, Maisie. Now, the situation is “literally a life-or-death thing,” she said.

Maisie has a condition called short bowel syndrome, which prevents her from absorbing enough nutrients from food. Ellis said Maisie gets half of her nutrients through intravenous treatment and half through EleCare.

The day of the recall, Ellis had four or five cases of Elecare formula at home. She checked the cans and saw they were affected by the recall. Suddenly the entire stock of her daughter’s vital food source was wiped out.

On Saturday, Ellis tried to give her daughter a different formula, with devastating results. “Maisie threw up all day long,” she said.

Ellis, who lives in Alexandria, Virginia, drove to multiple stores before finding a single case of the EleCare formula. One case lasts Maisie about two weeks.

Even finding regular formula has become difficult for parents, many of whom described the extraordinary lengths they’ve gone to for weeks and months to score even a single can or bottle.

But specialized formula is even harder to locate amid the widespread shortage. Parents are driving to neighboring states to try their luck, and many are pleading for help on social media, imploring strangers to share or even barter any extra supply they may have.

Ellis was fortunate to find that help just a few steps away. Her next-door neighbor, Elizabeth Coco, is able to share some of her EleCare supply — for now.

A shared struggle

The two moms are bonded by their love and nurturing of their medically fragile children. In many ways, Coco’s son Thomas, who goes by T, is a typical soon-to-be 5-year-old.

“He has long blond curly hair and he’s always smiling and laughing,” said Coco. Like Maisie, T also desperately needs Elecare Jr., a version of the formula for older children. It’s his primary source of nutrition and he is fed overnight through a G-tube, a surgically implanted device that provides nutrition directly into the stomach for supplemental feeding.

Coco explained that her son suffers with four rare diseases, 23 known food allergies and a long list of unknown triggers that can cause a deadly reaction. “He has gone into shock three times in my arms,” she said, making him extremely fearful of food.

The list of safe foods T can eat is very limited, and Elecare is the only formula he can consume safely.

“He has failed every other amino acid and hypoallergenic formula they can swap him to,” Coco wrote in a desperate Facebook post on Feb. 19, two days after the FDA recall.

All 54 cans of the formula she had for T were recalled, leaving her with no food for her son and no choice but to put him to bed without the nutrition he needed. “I was asking help from anybody,” Coco said.

Grocery stores nearby were out of stock. Medical supply shops had no inventory and she couldn’t get any more emergency supply from her doctor’s office.

“I shared that post and one mom told another, who told a friend who told another mom,” she said. She has since received some supply from parents in Canada, Ohio and other places around the country. “I have enough to feed him for two months as long as he stays healthy,” Coco said. And she’s sharing some of it with Ellis for Maisie.

The emotional toll of the last few days has been extreme. “This is a bad situation. But when you have kids like T, you never panic. You learn to move forward in a logical way,” she said.

Dr. Steve Abrams, a neonatologist and former chair of the American Academy of Pediatrics committee on nutrition, said the ongoing shortage of all kinds of formula, coupled with the recent recall of Abbott’s specialized brands, has created a very difficult situation for parents whose children require it as essential food.

“Pediatricians are getting calls nonstop,” Abrams said. “We don’t know how long the shortage will last, but I don’t anticipate that it will be resolved quickly.”

A spokesperson for Abbott said in an email to CNN Business that the company is leveraging its global manufacturing and supply network to meet demand and “increasing production at an FDA-approved facility in Europe and air freighting product in.”

The spokesperson noted that the recall only impacts batches of formulas produced and distributed in its Sturgis, Michigan, facility, and said that no other products that Abbot distributes had so far tested positive for salmonella or other pathogens.

“Our other U.S. plants are running at maximum capacity and we’re converting some production of other liquid products to Similac,” she said, adding that the company “values the trust parents place in us for high quality and safe infant nutrition and will do whatever it takes to resolve this situation. We regret this situation and the impact it will have on parents, caregivers, patients and health care professionals.”

Learning to cope

First-time mom Tran Trivedi was relieved when she finally found a formula, Alimentum, that suited her 4-month-old son, Armin.

“He could drink it without the gassiness and pain he would get from other formulas,” she said.

Like plenty of other parents, she’s spent hours every day trying to track down more supply. “I placed an order at one store on Feb. 1 and it’s still on backorder with no time frame on when it will ship,” she said.

The recall also wiped out her stock, and Trivedi currently has six bottles of formula she was able to find in a store and from friends. It’s enough for about two weeks of feeding.

“It’s so stressful. I shouldn’t be struggling so much to find formula for my baby. Not everyone can breastfeed their baby. I pump and I’m not making enough for him,” said Trivedi, breaking down in tears.

“It’s not easy at all driving around everywhere with your newborn who has to eat and sleep and grow,” she said. “It shouldn’t be this way.”

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Sticker shock: 80% of car buyers now paying above suggested retail price

Customers view a vehicle for sale at a Ford Motor Co. dealership in Richmond, California, on July 1, 2021. Eighty percent of new car buyers in January paid more than the manufacturer’s suggested retail price, according to data from Edmunds. (David Paul Morris, Bloomberg, Getty Images via CNN)

Estimated read time: 5-6 minutes

ATLANTA — Only a year ago almost no one paid the full sticker price when buying a new car. Now you’re lucky if you can.

In perhaps the most striking sign of the change in new car pricing, 80% of new car buyers in January paid more than the manufacturer’s suggested retail price, according to data from Edmunds, the online site that tracks car rankings and prices. That’s what’s commonly known as sticker price.

It’s the latest manifestation of the fact that a shortage of parts, especially computer chips, has caused automakers to temporarily halt production at various plants. That has left dealers with fewer vehicles than they need to meet customer demand.

That has resulted the average transaction price hitting $45,717 in January, or $728 above MSRP.

It’s up nearly $6,000, or 15%, from January a year ago, and about $7,500 higher than the average price paid in January 2020, just before the pandemic started roiling the auto industry.

Only 2% of buyers paid above MSRP a year ago, with buyers paying on average about $2,150 less than sticker at that time.

“Demand is through the roof, and supplies are historically tight,” said Ivan Drury, senior manager of insights for Edmunds. He said if a buyer isn’t willing to pay above the sticker price, the dealer can be confident there will soon be another buyer who will.

“We’re talking only a 10- to 11-day average for the time vehicles are on the lot,” he said. “We’ve never seen that.”

Part of the increase in pricing is because consumers are increasingly buying more SUVs and pickups and fewer sedans, which are typically less expensive. They’re also choosing more expensive options, such as automatic braking and lane departure warnings that are designed to make the cars safer.

But the biggest factor behind the price increases is the shortage of cars.

The only good news for car buyers is that used car prices are going up even faster than new car prices, due to an even tighter supply of vehicles in that market. The average value of a trade-in has increased $8,000 in the last year, according to Edmunds.

Dealers are the big winners

The biggest winners from the current prices: auto dealers, and not the automakers. Until Tesla came along with its company-owned stores and direct sales to consumers, all automakers used a network of independent businesses to sell cars to American buyers. Dealers would buy cars wholesale at set prices from automakers. The price paid by consumers were then negotiated with the dealer.

So while automakers benefit from not having to offer some of the cash-back offers or other incentives to boost demand, the auto dealers are reporting booming profits that come from the higher prices.

AutoNation, the nation’s largest car dealership, just reported record quarterly and annual profits Thursday, even though it sold only 2% of the new cars above the manufacturer’s suggested retail price in 2021. It did so by selling cars at or near sticker price far more often than in the past.

But many car buyers are upset with the idea of paying over sticker price. And their worries are causing concern among some of the automakers themselves.

Both General Motors and Ford have sent letters to their dealers telling them that they could have their allocation of new vehicles reduced and redirected to other dealers if it’s determined they’re engaged in what the automakers consider abusive practices.

In particular, GM and Ford are concerned that customers who have put down a deposit for a reservation for upcoming models, particularly EV models like the Ford F-150 Lightning, are being told that they must pay thousands above the list price they expected to pay. Nearly 200,000 Ford customers made deposits for a Lightning, for example, and GM has similar reservation list for some of its recent and upcoming EVs, such as the GMC Hummer EV pickup and the Cadillac Lyriq.

“It has come to our attention that in connection with some of these announcements and launches, a small number of dealers have engaged in practices that do not support a positive sales experience for our customers,” said a letter that Steve Carlisle, president of GM North America, sent to dealers. “Specifically, it has come to our attention that some dealerships have attempted to demand money above and beyond the reservation amounts set in GM’s program rules and/or have requested customers to pay sums far in excess of MSRP in order to purchase or lease a vehicle.”

Ford spokesman Said Deep said that Ford has notified dealers about similar concerns surrounding the Lightning, which is due to start production in the spring. Customers with reservations could start completing their orders starting on Jan. 4. He added that the company also is looking at the large premiums for other hot models, including the Mustang Mach-E and the Bronco, a gasoline-powered car.

But neither automaker said they are outright prohibiting the widespread use of charging over list price by dealers, only when the price is “far in excess” of that benchmark.

AutoNation CEO Michael Manley, who was previously CEO of Fiat Chrysler before it merged with France’s PSA Group to form Stellantis, said he didn’t believe pricing over sticker is a problem for the industry’s reputation. He said prices should be close to the manufacturer’s suggested retail price, and he hoped and expected prices to be closer to that level even once the supply of vehicles is no longer constrained.

“The levels of profitability for both (automaker) and dealers clearly show the benefits of selling vehicles at MSRP. And what a concept, right? Selling at MSRP,” he said to investors. “I think it’s equally clear that significant discounting and high incentives can also damage a brand, which is another reason for our industry to balance appropriately supply and demand.”

If he’s right, that means the days of paying thousands below sticker are over.

Paying over the manufacturer’s suggested retail price is not going away any time soon, according to Drury, of Edmunds. With projections that supply of vehicles could remain tight into the second half of this year, it could be 2023 before paying over sticker price becomes rare once again.

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Ivermectin doesn’t prevent severe disease from COVID-19, new study finds

The antiparasitic drug ivermectin doesn’t prevent severe disease from COVID-19 any more effectively than symptom management and close observation by medical professionals, a new study finds.
(Dimas Ardian, Bloomberg via Getty Images)

Estimated read time: 3-4 minutes

WASHINGTON — The antiparasitic drug ivermectin doesn’t prevent severe disease from COVID-19 any more effectively than symptom management and close observation by medical professionals, according to a study published Friday in the journal JAMA Internal Medicine.

The study enrolled nearly 500 people 50 and older who were at risk of severe COVID-19 because of their age and underlying health. These patients were treated at 20 public hospitals and a quarantine center in Malaysia in 2021.

Half of the patients took a relatively high dose of oral ivermectin for five days, and the other half — the comparison group — received treatment for their symptoms, such as fever-reducing medications. All were monitored for the progression of the disease.

There was no difference in outcomes between the groups. In fact, slightly more patients in the ivermectin group went on to need extra oxygen compared with those who took a placebo, though the difference was not statistically significant.

This was the main outcome researchers studied, but they also looked at whether patients needed to be hospitalized, had to go on a ventilator, needed intensive care or died from their infections. There was no meaningful difference in outcomes between the group that took ivermectin and those who got the placebo treatment.

The study had several important strengths:

  • It was a randomized-controlled trial, the gold standard of medical research, in which researchers test an intervention against a placebo.
  • The study enrolled patients most likely to be at risk from severe COVID-19 disease: those over 50 with at least one additional risk factor and mild to moderate symptoms. People who had no symptoms or who had advanced disease were excluded.
  • Participants were enrolled only after a PCR test confirmed COVID-19 infection.
  • It was a multicenter trial conducted at 20 public hospitals and a COVID-19 quarantine center in Malaysia between May 31 and Oct. 25, 2021.

In addition to the fact that ivermectin didn’t work, people who took it had more side effects than those who didn’t, and sometimes those side effects were severe, including heart attacks, anemia and diarrhea that led to shock.

“The higher incidence of side effects with ivermectin in our study raises concerns about the widespread use of this drug outside clinical trial setting,” lead researcher Dr. Steven Lim told CNN in an email.

“The public should understand that the highly touted safety profile of ivermectin is related to its use as an anti-parasitic drug. The use of ivermectin as an antiviral in COVID-19 is a totally different ball game, with notable differences in dosing, duration and mechanism of actions,” wrote Lim, an infectious-disease specialist at Raja Permaisuri Bainun Hospital in Perak, Malaysia.

Two previous randomized-controlled trials of ivermectin for COVID-19, from Argentina and Colombia, concluded that there was no significant effect on symptoms or hospitalization rates, prompting the World Health Organization to advise that ivermectin be used to treat Covid-19 only within the setting of clinical trials.

Both the U.S. Centers for Disease Control and Prevention and the U.S. Food and Drug Administration have warned the public and prescribers not to use ivermectin to treat COVID-19.

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