Tag Archives: Cure

Expert explains why pharmacist’s viral ‘hangover cure’ really works

The party season is in full swing, but nothing kills that festive cheer quicker than a prolonged and painful hangover.

However, a US pharmacist has shared the hangover “cure” she swears is “100 per cent effective” – and those who have put it to the test agree.

Ari, a licenced doctor in LA, revealed she takes vitamin B complex, magnesium and a folic acid supplement alongside an electrolyte drink, claiming it is “single-handedly the most effective way” to beat those awful morning after symptoms.

Describing the concoction as an “oral version of an IV fluid bag”, Ari said it helps ease symptoms of dehydration and replenishes electrolytes.

Her tip has since gone viral on TikTok, with many sharing follow-up videos telling of their success. So does it really work? According to Australian experts, there’s a scientific reason why it is so effective.

Does this viral hangover ‘cure’ work?

Social media users have been raving about Ari’s tip, with one Australian user stating people “dying a slow death from a hangover should take notes”.

Everything listed in the viral tip is backed by scientific reason as to why the method is effective.
TikTok

After buying all the items needed, TikTok user @brokebutmakeitboujee said: “It works, it really works.

“All of that is super cheap – probably the most expensive thing is the Hydralyte – but you know what, it’s worth it to not be dying at Christmas parties,” she said.

Clinical nutritionist Sally O’Neil, who recently launched health coaching platform @status.8020, told news.com.au she hasn’t actually tried the “hack” but explained why it “makes sense”.

“Theoretically and anecdotally, it would make sense that it can help relieve a hangover, yes,” she said.

“Depending on the dose and purity of the supplements taken (which the viral ‘cure’ doesn’t mention) it may lessen the effects only slightly in some, whilst for others it may be very effective.”

However, she warned the doses given out in IV bags in hospitals are “often much higher than those recommended on the back of over-the-counter labels of vitamins” which could also affect results.

Why is it effective?

“In current studies, hangover cures that show positive effects are those that inhibit accelerating alcohol metabolism,” Sally said.

“B vitamins are essential enzymes that are used in the process of turning carbohydrates and alcohol into energy. Thus, taking more B vitamins can assist your body in efficiently metabolising (breaking down) alcohol.

Clinical nutritionist Sally O’Neil explained the science behind the tip.
TikTok

“The electrolytes in the ‘cure’ (such as sodium, potassium, magnesium and calcium) may improve symptoms where a deficiency is present, but there doesn’t seem to be evidence that a single bout of drinking causes electrolyte deficiencies or imbalances, assuming no vomiting or diarrhoea has occurred.

“In this instance, electrolytes may assist.”

How to follow the hangover ‘cure’

While there’s scientific research to back up Ari’s hangover “cure”, Sally pointed out she hasn’t advised anyone the best process for using it.

“There is no clinical evidence that shows a significant difference between taking B vitamins for hangovers in the morning or at night. In other words, you can take it at any time that you find convenient,” she said.

“Just make sure to avoid caffeine for at least an hour after taking supplements as it can inhibit efficient absorption of the vitamin.”

After buying all the items needed, TikTok user @brokebutmakeitboujee said: “It works, it really works.
TikTok

Sally also warned anyone wanting to try it this silly season, to be mindful of the quality of product they are buying.

“Not all ‘vitamin B complexes’ contain the same B vitamins or ratios,” she said.

“B1 (Thiamine), B2 (Riboflavin), folic acid, B6 and B12 all play a major role in the functioning of the brain and nervous system and arguably could be beneficial in this instance.”

However, electrolytes can be taken once a loss has occurred, meaning after drinking is fine.

“Remember – the only reliable hangover cure is limiting alcohol intake in the first place,” she said.

Putting it to the test

Of course,news.com.au couldn’t tell you about a hangover cure without testing it for ourselves, and I was happy to be the guinea pig.

I decided to take my vitamin B complex and folic acid the morning of an event, then had an electrolyte drink and the magnesium supplement when I got home post-party.

The next morning I was pleasantly surprised as I’d slept through, something which never happens after a few drinks. I also didn’t have any other pesky symptoms such as headaches or cravings for junk food, saving my bank balance and my waistline.

What is a hangover?

Hangovers “happen” because of alcohol and its effects on the brain,” Sally said.

“Whilst we don’t actually know the specific mechanism of action, we do have some ideas.

“Ethanol, recognised as a toxin by the body, triggers an inflammatory response that damages and dysregulates neurons in the brain.

“Headaches and other lovely hangover symptoms are likely caused (in part) by the damage from this inflammation and oxidative stress suffered by the brain and other tissues.

“This can result in impaired energy metabolism.”

Sally – who also runs the Instagram page @TheFitFoodieBlog – explained another chemical found in some liquors can also “worsen” hangovers.

Sally – who also runs the Instagram page @TheFitFoodieBlog – explained another chemical found in some liquors can also “worsen” hangovers.

“Congeners are a chemical found in some alcohols that may be another contributing factor,” she said.

“They’re found in darker liquors such as whisky, rum and brandy, along with red wine. “Studies seem to show congeners worsen hangovers when compared with other drinks of the same alcohol content.

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Ranking 2022 college football bowl games, 41-1: Rose, Cure, Alamo, Sun among major non-playoff highlights

I’m told by more and more people how meaningless bowl games have become each college football season. With the College Football Playoff field set to expand to 12 teams in 2024, this sentiment will only grow more prevalent — and I get it. You can never be sure which teams will take it seriously, and many of the best players opt out of the games to prepare for the NFL Draft.

But, you know what? I love bowls. Every single one of them. I love college football, and bowl games are college football games. I don’t care if the team’s leading rusher has decided to sit out. That only means I get to see what the new guy brings to the table. It also gives me a chance to see more college football.

If you’re a fan of college football, what’s not to love? Bowl Season isn’t the regular season or the playoff, but it’s a wonderful time of year. There are games on nearly every day of the week at random times! That’s incredible! That’s something to be celebrated!

Every year, I choose to celebrate it by watching them all, but I cover college football for a living. I know most people aren’t able to dedicate that much time to these games, which is why I rank the bowls for you here at CBS Sports every year. Now, as I said, all these games are incredible and worth your time, but if you’re on a budget, hopefully my handy guide can help you decide which games to watch and why. All times below Eastern

41. First Responder Bowl: Memphis vs. Utah State

Tuesday, Dec. 27, 3:15 p.m. — This game has a chance to be exciting, but it’s hard to tell which version of each team will show up. Memphis and Utah State looked like a different team each week, which helps explain why both finished the regular season with 6-6 records. The good news is we should know how this game will go pretty quickly. Utah State’s six wins tended to be close battles, but the losses came by an average of 23 points each.

40. Bahamas Bowl: UAB vs. Miami (OH)

Friday, Dec. 16, 11:30 a.m. — UAB will be a much more interesting team to follow next season when Trent Dilfer takes over as coach. The Blazers went 6-6 this season and are led by running back DeWayne McBride, who rushed for 1,713 yards and 19 touchdowns. They’ve been much better at home, where they went 5-1.

As for the RedHawks, it’s been an up-and-down campaign as well. They beat Northwestern in September, which seemed like a bigger deal at the time, but they were only 4-4 in the MAC. However, they did win three of their last four games to earn bowl eligibility.

39. Myrtle Beach Bowl: Marshall vs. UConn

Monday, Dec. 19, 2:30 p.m. — He’s not going to win any of them, but UConn’s Jim Mora should get consideration for Coach of the Year awards. Mora took over a UConn program that had gone 4-31 in its last three seasons (it didn’t play in 2020) and guided the Huskies to a bowl game. That’s a stunning turnaround! They also improved as the year went on, starting 1-4 and going 6-2 down the stretch while picking up wins over eventual Mountain West champ Fresno State and Boston College.

Marshall is 8-4 and had a successful first season in the Sun Belt. The Herd beat Notre Dame in South Bend early in the season and took down a James Madison squad that looked to be one of the best in the Sun Belt. They’ve won four in a row thanks to the churning legs of Khalan Laborn (1,423 yards rushing, 16 TD) and a sturdy defense. The only reason I have this game ranked this low is that I think there’s a good chance Marshall will run away with it.

38. LendingTree Bowl: Southern Miss vs. Rice

Saturday, Dec. 17, 5:45 p.m. — Finally, after all these years, the rivalry is renewed! OK, so there’s no real rivalry, but Southern Miss used to be in Conference USA before moving to the Sun Belt this season, where it went 6-6 overall but limped to the finish line. The Eagles have lost three of their last four but still have an exciting player in running back Frank Gore Jr.

Rice is the only 5-7 team to reach the postseason this year, but none of those five wins came against a team with a winning record. The Owls have also lost their last three and four of their last five, so, yeah, it’s not the sexiest matchup you’ll find.

37. Birmingham Bowl: Coastal Carolina vs. East Carolina

Tuesday, Dec. 27, 6:45 p.m. — This game would rank a lot higher if Coastal Carolina still had coach Jamey Chadwell and quarterback Grayson McCall, but their status is up in the air. Chadwell has accepted the coaching job at Liberty, and I don’t imagine he will stick around to lead the Chanticleers in this one. As for McCall, he’s one of the more exciting players in the country but suffered what was believed to be a season-ending injury earlier this year only to return for the 45-26 Sun Belt Championship Game loss to Troy. Fun fact about the Chants: They’re 9-3 on the season, but after blowout losses in their last two games, they have a point differential of -12 on the season. I can’t imagine there have been many nine-win teams with a negative point differential in the past.

East Carolina is led by one of my favorite players in the country, QB Holton Ahlers. Ahlers has played for the Pirates for what feels like 25 years, and he’s been a productive player in each of those 25 seasons. However, none of those seasons — and it has only been five, in truth — have ended in a bowl game until this year. This is East Carolina’s first postseason appearance since the 2014 Birmingham Bowl.

36. Frisco Bowl: Boise State vs. North Texas

Saturday, Dec. 17, 9:15 p.m. — Boise State’s entire season turned around following a 27-10 loss to UTEP in September. That’s when Hank Bachmeier lost the starting QB job, and the team fired its offensive coordinator before bringing back Dirk Koetter. Since then, Taylen Green and the Broncos offense have been much more dangerous, if inconsistent. Green’s a big play waiting to happen on each snap, but the Boise defense is the best unit on the field in this game. Unfortunately for the Broncos, after going 8-0 in conference play during the regular season, they lost in the MWC championship to Fresno State 28-16 after beating the Bulldogs in the regular season.

It’s a feeling to which North Texas can relate; the Mean Green reached the Conference USA Championship Game themselves but were routed by UTSA 48-27. Unfortunately for coach Seth Littrell, reaching the conference championship was not enough to save his job as he was fired on Dec. 4. The Mean Green offense is led by QB Austin Aune, who has thrown for 3,309 yards and 32 touchdowns this season at the age of 29. Aune was a TCU commit out of high school but was drafted by the New York Yankees in the second round of the 2012 MLB Draft. He opted to play baseball but returned to football in 2018 after his baseball career didn’t pan out.

35. Quick Lane Bowl: New Mexico State vs. Bowling Green

Monday, Dec. 26, 2:30 p.m. — This is not the sexiest matchup on paper, but we know one thing: Both of these teams will be happy to be here. Bowling Green is 6-6 and playing in its first bowl game since the Falcons reached the GoDaddy Bowl in 2015. They won 10 games that season but haven’t won more than four games in a season until this year.

They’ll face a New Mexico State team playing only the fifth bowl game in program history. The last appearance came in 2017, which was the Aggies’ last season in the Sun Belt. They’ve been Independent for the last five years and have found life very difficult. They went 8-30 from 2018-21, but Jerry Kill has turned this program around quickly in his first season. The Aggies started the year 1-5 before winning five of their last six to get here.

34. Camellia Bowl: Georgia Southern vs. Buffalo

Tuesday, Dec. 27, 12 p.m. — A matchup of 6-6 teams with some upside. For those who don’t pay close attention to the Sun Belt (and why don’t you?), Georgia Southern is now led by former USC coach Clay Helton, who helped the Eagles get off to a surprising start. This is the same Georgia Southern team that went to Lincoln, Nebraska, earlier this season and ended the Scott Frost Era with a 45-42 win over the Cornhuskers. That was part of a 3-1 start to the season, but the Eagles hit hard times after that. Still, they’re a fun team that scores points nearly as quickly as it allows them, which can make for a fun bowl experience.

Then there’s Buffalo, which has given new meaning to the running of the Bulls. Buffalo started the season 0-3 before winning five straight. Then, the Bulls dropped three in a row and were on the verge of missing bowl season entirely before coming back to beat Akron in a game that had been postponed due to 6 feet of snow falling in the Buffalo area earlier in November. Something tells me there won’t be snow in the forecast for this game.

33. Hawaii Bowl: Middle Tennessee vs. San Diego State

Saturday, Dec. 24, 8 p.m. — There’s no tradition greater than getting the family together on Christmas Eve, gathering around the fireplace and opening the gift that is the Hawaii Bowl. Sure, the matchup isn’t always great, and you’ll have a hard time explaining to your relatives how Rick Stockstill is an institution in Murfreesboro, Tennessee, but don’t worry. You can also tell them about the time that the Blue raiders beat the Miami Hurricanes 45-31 earlier this season, and since they’re a casual fan, they won’t even realize that’s not a big deal anymore. In fact, they’ll probably think it’s one of the biggest upsets of all time. Let them think so as a small gift to them.

Your relative might also recognize San Diego State coach Brady Hoke as “the guy who coached Michigan, right? when they were bad?” You can confirm that but also clarify that Mr. Hoke has done a solid job with the Aztecs. Sure, they’re only 7-5, but their five losses this season came against teams that went a combined 42-21, including two conference champions (Utah and Fresno State).

32. Independence Bowl: Houston vs. Louisiana

Friday, Dec. 23, 3 p.m. — Here’s my concern about this game: When the Cougars are on, they’re enjoyable to watch. They can put up points in a hurry, and QB Clayton Tune (3,845 yards passing, 491 rushing, 42 total TD) is a stud, as is receiver Tank Dell (1,354 yards, 15 TD). But you never know which Houston is going to show up. Dana Holgorsen’s team is more difficult to predict than a random number generator, and you have to question how excited this team will be for an Independence Bowl against Louisiana. If they care, we’ve got a shot at having fun here; if they don’t, we’ll slog through.

The same question can be asked of the Ragin’ Cajuns. While this isn’t a program likely to take a bowl appearance for granted, the Cajuns spent the last few seasons playing for Sun Belt titles. This year, they needed a 41-13 win over Texas State in the season’s final game to earn bowl eligibility. This game has a high ceiling but a low floor, too.

31. Armed Forces Bowl: Baylor vs. Air Force

Thursday, Dec. 22, 7:30 p.m. — Baylor won the Big 12 last year and reached the Sugar Bowl thanks primarily to a defense that was one of the best in the country. This year, the Bears are only 6-6 because that defense abandoned them. While this game looks great on paper, I think there’s bigger blowout potential here than most will assume. 

Baylor ranked 99th in the country this year in success rate against the run and 92nd in expected points added (EPA) per rush attempt. That’s not great when facing an option team like Air Force! The Falcons are 9-3 on the season behind their rushing attack. They run the ball more often than any team in the country (88.8% of the time!) and rank 14th in yards per carry (5.40) and 13th in EPA per rush (0.14).

30. Potato Bowl: San Jose State vs. Eastern Michigan

Tuesday, Dec. 20, 3:30 p.m. — Early in the season, San Jose State looked like one of the best teams in the Mountain West. The Spartans were 4-2 with close road losses to Auburn and Fresno State. Then tragedy struck when running back Camdan McWright was struck and killed by a bus. The loss had a profound impact on the Spartans’ season, but they finished the season 7-4 behind quarterback Chevan Cordeiro, running back Kairee Robinson and receiver Elijah Cooks.

Eastern Michigan finished the regular season 8-4 and four points shy of playing for a MAC title. The Eagles finished with the same 5-3 record in conference play that Toledo did, but their 27-24 loss to the Rockets served as the tie-breaker. Still, the Eagles recovered from that loss with three wins to finish the regular season, and look to finish with nine wins for the first time since going 10-2 in 1987.

29. Pinstripe Bowl: Minnesota vs. Syracuse

Thursday, Dec. 29, 2 p.m. — I have a feeling in the pit of my stomach that these teams could combine to make this ranking look very stupid when bowl season ends. While they’re both Power Five teams, this isn’t the most exciting matchup. Syracuse does a great job defensively of limiting explosive plays, and Minnesota’s offense isn’t built on big plays. We’re likely to see a lot of clock-churning drives in this one, but on the bright side, that should keep things close.

On an even brighter side, it’s another chance to see one of the best running backs in the country. Minnesota’s Mohamed Ibrahim tore his Achilles last season but returned this year to rush for 1,594 yards and 19 touchdowns. His 144.91 rushing yards per game ranks second nationally. The battle between him and Syracuse running back Sean Tucker (1,060 yards, 11 TD) should be fun.

28. Gasparilla Bowl: Wake Forest vs. Missouri

Friday, Dec. 23, 6:30 p.m. — Fun fact about Wake Forest QB Sam Hartman. He missed time early in the season due to an undisclosed medical condition. Hartman shared the news after the regular season of needing a rib removed, keeping it in his freezer and planning to have a necklace made out of it. So, you know that now! Congratulations! You should also know that Hartman has been one of the most productive QBs in the country for a few years now, and this Wake Forest offense is capable of putting up a lot of points when playing well. It’s also capable of turning the ball over with alarming regularity, which makes it entertaining 100% of the time as long as you don’t have a rooting interest.

The problem here is Missouri. The Tigers went 6-6, but outside of a 23-10 win over South Carolina, they don’t have many wins to get excited about. They’re strong enough defensively to keep most games close, but we’ve seen a significant number of Tigers players hit the transfer portal since the season ended. The questions about who will be available for this game make it hard for me to rank it much higher than this.

27. Boca Raton Bowl: Toledo vs. Liberty

Tuesday, Dec. 20, 7:30 p.m. — This game has a low floor but could be very entertaining if both teams show up. Liberty began the season 8-1 and entered the College Football Playoff Rankings after beating Arkansas 21-19. That win amplified the rumors about Hugh Freeze leaving to take the Auburn job, and the Flames lost their final three games of the season. That includes a 49-14 loss to New Mexico State in which the team looked like it had been told by its coach that he was leaving, and they didn’t take it very well. What Liberty team shows up for this game? Will it be a team that wants to impress new coach Jamey Chadwell or a team that just wants to finish the season?

Toledo could crush the Flames if they don’t show up ready to play. The Rockets won the MAC, beating Ohio 17-7 in the title game after going 5-3 in conference play and 8-5 overall. This is an inconsistent team, but they’ve been much better when QB Dequan Finn (2,127 yards passing, 608 rushing, 30 TD) has been healthy. He played against Ohio and should be closer to 100% health by the time this game is played.

26. Military Bowl: Duke vs. UCF

Wednesday, Dec. 28, 2 p.m. — Want a peek behind the curtain? When it comes to these bowl rankings, the 10 best and the 10 worst are usually pretty obvious, and then the 21 games in the middle are basically the same. I could’ve told you that long ago, but I wanted to save it as a reward for those who read this far. Well, unless you’re a Duke or UCF fan who scanned this far just to see where your game is ranked. If you did, that’s cheating; go back to the beginning and start over.

The point is that this game has all the potential in the world to be great, but I wonder about the matchup. UCF is a team that had much higher hopes than a Military Bowl appearance. It’s also a team that runs the ball a lot and will face a Duke team that finished 34th nationally in EPA per rush on defense. Also, I’d be remiss if I didn’t shout out Duke coach Mike Elko for the fantastic job he’s done in his first season with the Blue Devils. This is Duke’s first bowl game since 2018, and the Blue Devils have won more games this season (eight) than they did the last two years combined (five). They also went 5-3 in the ACC, giving them their first winning record in conference play since 2014.

25. Guaranteed Rate Bowl: Oklahoma State vs. Wisconsin

Tuesday, Dec. 27, 10:15 p.m. — If you’d have told me before the season that we were getting a bowl game between Oklahoma State and Wisconsin, I’d have assumed it was in a New Year’s Six bowl. Wisconsin was the favorite in the Big Ten West and Oklahoma State was a serious threat to win the Big 12. Instead, the Badgers went 6-6 and fired coach Paul Chryst during the season, and enter this game with starting QB Graham Mertz who opted to enter the transfer portal. Oklahoma State started 6-1 but lost four of five to finish the regular season.

I have no idea what to expect here. Neither of these offenses performed well in 2022, and it’s hard to imagine a couple weeks of bowl practices will be enough to figure it out. 

24. New Mexico Bowl: BYU vs. SMU

Saturday, Dec. 17, 7:30 p.m. — We’ve got potential here. SMU averaged 38.4 points per game this season (13th nationally) while BYU scored 31.9 (40th). Defensively, the Mustangs allowed 34.7 per game (123rd) and BYU allowed 30.0 (100th). If you’re the betting type, you might want to have your head examined if you’re considering the under because I don’t see a lot of punts flying through the big blue skies of Albuquerque when these two meet.

The Mustangs won six of their last eight games to finish the season 7-5 and have one of the most talented receivers in the country in Rashee Rice (96 receptions, 1,355 yards, 10 TD). He’s likely to hear his name called early in the NFL Draft this spring. For the Cougars, keep an eye on QB Jaren Hall, who threw for 31 touchdowns. He looks to be the next in a long line of prolific BYU passers.

23. New Orleans Bowl: Western Kentucky vs. South Alabama

Wednesday, Dec. 21, 9 p.m. — Ever had a friend who listens to a bunch of musicians you’ve never heard of? They’ll tell you about this concert they saw at this tiny venue featuring an act with a name that makes no sense and say it was a life-changing experience. You’ll shrug it off, “Greg being Greg” or whatever, but deep down inside you’ll fear you’re missing out. What if Greg’s right? What if Greg is onto something you would love if only you gave it a shot?

Greg is really into the New Orleans Bowl this year. Greg wants you to know all about South Alabama. The Jaguars didn’t win the Sun Belt, but they’re the second-best team in the league, at worst. They just play in the wrong division. They’re 10-2, and their lone losses were a one-point loss at UCLA and a four-point loss to Sun Belt champion Troy. The defense is fierce. Running back LaDamian Webb is a beast. You need to see them. You also need to see them against a Western Kentucky offense that writes some crazy songs. They can score on anybody. Austin Reed threw for 4,247 yards and 36 touchdowns. You’ve got to see him live, man. Greg knows. Listen to Greg.

22. Gator Bowl: (21) Notre Dame vs. (19) South Carolina

Friday, Dec. 30, 3:30 p.m. — South Carolina finished the season with a bang. The Gamecocks started 6-3, but none of their six wins were that impressive unless you’re really high on South Carolina. After a 38-6 loss to Florida, this team looked destined to finish 6-6 with games against Tennessee and Clemson remaining. Then the Gamecocks went and beat Tennessee 63-38 and followed it up with a 31-30 road win over Clemson. In consecutive weeks, the Gamecocks destroyed the playoff hopes (however faint) of a division rival and a state rival. It’s the stuff of which dreams are made.

Now they get a shot to take down one of the most decorated programs in college football history when they face Notre Dame in the Gator Bowl. So why am I ranking this game so low? Well, Notre Dame starting QB Drew Pyne is in the transfer portal, and he began the season as the backup. We could also see other draft prospects in this game opt out, which hurts the potential. I won’t be surprised if it’s close, but I can’t count on it being exciting.

21. Arizona Bowl: Ohio vs. Wyoming

Friday, Dec. 30, 4:30 p.m. — Every season, I fall in love with a team because I figure out that it’s better than everybody realizes and win a bunch of money betting on it. This season that team was Ohio, which covered the spread in nine straight games by an average of 14 points each before finally falling in the MAC Championship Game against Toledo. I will always love Kurtis Rourke and the 2022 Bobcats, and I will probably bet on them in this game out of gratitude. The problem is Rourke has missed the last couple of games with an injury, and I don’t know what his availability will be for this one.

That’s important against a Wyoming team that is saltier than a Chicago street in winter. When I watch Craig Bohl’s Cowboys, I get the impression they’d rather win a game 9-7 than 42-3. When it works, it’s great, but when it doesn’t, things get ugly. Only one of Wyoming’s five losses this season was a one-score loss. Only two of their games saw at least 50 points scored. So they’re usually playing low-scoring blowouts or competitive affairs, but the point is they’re almost always low-scoring. Hard to rank a game much higher than this when you don’t expect many fireworks.

20. Citrus Bowl: (17) LSU vs. Purdue

Monday, Jan. 2, 1 p.m. — It’s a battle of two teams that exceeded expectations, but one of them won’t be as excited about it. Nobody was expecting too much of LSU in Brian Kelly’s first season, but the Tigers upset Alabama to help them win the SEC West. The problem is that a few weeks ago, the Tigers thought they had a shot to reach the College Football Playoff because of it but lost to a bad Texas A&M team 38-23. They followed it up with a 50-30 loss to Georgia in the SEC Championship Game, and are now riding a two-game losing streak as they prepare to play the Citrus Bowl. Will their top guys sit this one out, or could we see a wave of opt-outs?

Purdue was a surprise winner of the Big Ten West this season, but it wasn’t the result of dominance. The Boilermakers went 6-3 in conference and hung with Michigan for a half in the Big Ten Championship Game before getting steamrolled in the second half. It’s a team that’s long made a habit of pulling off upsets over higher-ranked teams, and it has an exciting offense that can put points on the board, so LSU better take it seriously. However, there’s a potential problem here. The Louisville job came open this week when Scott Satterfield left for Cincinnati, and Purdue’s Jeff Brohm — a former Louisville QB — was seen as the top target for Louisville before it hired Satterfield. The Cardinals are bound to be interested again, so will Brohm turn down his alma mater twice?

19. Sugar Bowl: (5) Alabama vs. (9) Kansas State

Saturday, Dec. 31, 12 p.m. — If these teams were playing at full strength, this would be a top-five game in these rankings, no questions asked. Well, Kansas State — the Big 12 champion who ended TCU’s undefeated run — might be at full strength for this game, and it would love to make another statement by finishing the season with a win over mighty Alabama. But how mighty will this Alabama be? This is a program that wants to win the SEC and a national title every season. It accomplished neither this year, and we’re probably going to see a lot of players opt out of this game, including last year’s Heisman winner Bryce Young and one of the nation’s best defensive players in Will Anderson.

That will stink because Kansas State is a genuinely good team, and it could beat Alabama even if the Tide didn’t have players opt out. Regardless, I want another chance to see Young and Anderson play in an Alabama uniform, and I don’t think we will get that chance. It takes a lot of the shine off this game. Now, that said, it’s still Alabama. The reserves are pretty talented, too, so there’s still a shot this game is great.

18. Liberty Bowl: Arkansas vs. Kansas

Wednesday, Dec. 28, 5:30 p.m. — Let me start by saying that, if reports are to be believed, it is incredibly lame that Missouri refused to play Kansas in a bowl game because that would’ve been great. That said, this is probably a better matchup than that game would’ve been! The Jayhawks were the darlings of the first half of the season after opening the year 5-0, but they went 1-6 down the stretch after losing QB Jalon Daniels to injury. If Daniels is healthy and available for this game, however, the Jayhawks have one of the most entertaining offenses in the country.

But so does Arkansas with QB K.J. Jefferson. Combining these explosive and interesting offenses with the two defenses on the field, we’re likely in for a tennis match. There’s a strong chance this game becomes one of those “last team with the ball wins” kind of games, and in a mid-tier bowl game with low stakes, what more can you ask for than that?

17. Music City Bowl: Iowa vs. Kentucky

Saturday, Dec. 31, 12 p.m. — OK, so here’s the thing. As a connoisseur of all kinds of college football, this matchup interests me. I don’t need high-octane offenses and a bunch of touchdowns to be entertained. I’m the kind of person who can tune into a field-position battle and enjoy that just as much as I would a 49-48 game. So these two offenses don’t scare me away.

The problem is we just saw this game last year as Kentucky defeated Iowa 20-17 in a very entertaining Citrus Bowl. Having the rematch a year later takes some of the shine off it. We can’t even go with the angle of Mark Stoops facing his alma mater because it was beaten to death last year. Furthermore, Iowa QB Spencer Petras won’t play in the game because of injury, and we might see Kentucky QB Will Levis sit it out, too. While it’s not ideal, it does increase the odds of this game getting really weird and ending with an 11-5 score or something. Stupid football can be incredible entertainment.

16. Duke’s Mayo Bowl: (23) NC State vs. Maryland

Friday, Dec. 30, 12 p.m. — This ranking will rise quickly if either Dave Doeren or Mike Locksley promises to let somebody dump a cooler of mayonnaise on their head like South Carolina’s Shane Beamer did last season; that should not be a one-time-only thing. In fact, every bowl game should dump whatever the product of the primary sponsor is over the coach after the game. Sure, that would be awful news for the winning coach of the Lockheed Martin Armed Forces Bowl, but if you want to make an omelet, you have to crack a few eggs.

The matchup here is an ACC reunion of two interesting teams. NC State is one of the most fascinating teams of 2022 because there’s no rational reason for it to be 8-4 considering the injuries it’s suffered. Doeren is clearly a practitioner of the dark arts. Then there’s Maryland, which sports some NFL talent at the receiver position and a QB in Taulia Tagovailoa who isn’t afraid to put the ball up there, for better or worse. This one is ranked No. 16 to start, but I won’t be surprised if it’s a top-five game in my post-bowl rankings.

15. Texas Bowl: Ole Miss vs. Texas Tech

Wednesday, Dec. 28, 9 p.m. — I’m happy Lane Kiffin stayed at Ole Miss instead of leaving for Auburn. Nothing against Auburn; I just think Ole Miss is a better fit for him. He can chill and put together fun, exciting teams without dealing with the insanity of Auburn. What does that have to do with the Texas Bowl? Nothing, but I’m 5,700 words into this thing, all right? My brain is going to wander at some point. Don’t worry, though, because I’m about to get back on track.

So, yeah, I like this matchup. If you haven’t seen Ole Miss yet in 2022, it’s an explosive offense. Unlike 2021, however, it’s built more on running the ball than vertical passing routes. It’ll be up against a Texas Tech team that was a certified pain in the butt in the Big 12 this season. The Red Raiders didn’t win every game, but Joey McGuire’s team fought you for every point you scored. It did so thanks in large part to a rush defense that ranked 39th nationally in success rate against the run, so this will be a fun matchup to follow.

14. Fenway Bowl: Louisville vs. Cincinnati

Saturday, Dec. 17, 11 a.m. — Fun fact, this game came in at No. 20 in my initial rankings. It felt like a perfect “middle of the order” bowl game. Then, the news arrived Monday morning that Louisville coach Scott Satterfield was leaving to take the job at Cincinnati. All of a sudden, a mostly anonymous bowl game in a baseball stadium took on a lot more meaning. All of which begs one question, and one question only:

Can Satterfield coach both teams?

It would probably be too much work to handle all the head-coaching duties, but maybe Satterfield can be “all-time play caller” like you had an “all-time QB” when playing with your friends as a child. Sure, it would be awkward for Louisville players and near impossible for Cincinnati players to run plays from a playbook they haven’t seen yet, but it would make for great television. Besides, if we don’t, this will be two teams playing under interim coaches with motivational questions. Having Satterfield coach both teams at once solves the problem!

13. Sun Bowl: (18) UCLA vs. Pitt

Friday, Dec. 30, 2 p.m. — UCLA doesn’t play boring games. OK, it started the season with boring wins over Bowling Green and Alabama State, and had a boring win over Stanford, but that was more on the opponents. Every other game was a roller coaster. There were bangers against South Alabama, Washington, Utah, Oregon and USC, just to name a few. Dorian Thompson-Robinson is a thrill ride and Zach Charbonnet is terrific as this offense is full of fun surprises.

Pitt coach Pat Narduzzi is going to hate it! Narduzzi doesn’t even like to see his own team score points. Still, just because their coach doesn’t like them, that doesn’t mean Pitt isn’t willing to get into a shootout with you, and it can put points on the board too. Running back Israel Abanikanda finished the season with 1,431 yards and a national-best 20 rushing touchdowns.

12. Orange Bowl: (6) Tennessee vs. (7) Clemson

Friday, Dec. 30, 8 p.m. — It is a literal Orange Bowl. In a perfect world, both teams would come out in all-orange uniforms and we’d see how well they’d be able to tell friend from foe. It would be hilarious. Of course, we could also see Tennessee come out in its gray uniforms and Clemson in purple, which would really ruin the vibe. And I’m not sure how many vibes this game can afford to lose because while it’s a matchup of top-10 teams, it doesn’t crack the top 10 of these rankings.

Tennessee isn’t the same team without quarterback Hendon Hooker, though it’s possible that with an extra month of preparation Joe Milton and the offense can function at the same high level it did with Hooker. But while many things can be said about Clemson’s offense, few adjectives used to describe it are complimentary, though with five-star freshman quarterback Cade Klubnik being named the starter after his performance in the ACC Championship Game after DJ Uiagalelei was benched, that could change in a hurry. 

11. Cheez-It Bowl: (13) Florida State vs. Oklahoma

Thursday, Dec. 29, 5:30 p.m. — Florida State fans wish there was a button they could hit that would start the season over with the Seminoles playing at this level right now. If that happened, the ‘Noles would probably end up winning the ACC and could even sneak into the College Football Playoff because it’s been one of the best teams in the country for over a month. There were close losses to NC State and Clemson in October, then five straight wins to finish the season, most in blowout fashion. QB Jordan Travis has ascended to another level and is one of the most exciting players to watch in the country.

So while there’s a chance this game turns into a blowout, even though Oklahoma is only 6-6, it has an offense capable of scoring in a hurry. This game has the potential to be an exciting shootout if the Sooners are healthy. I understand there’s also a good chance I look like a moron for ranking this game so highly if Bad Oklahoma shows up and Florida State wins by a billion. Whatever happens, at least I feel confident the final score won’t be 13-2.

10. Reliaquest Bowl: (22) Mississippi State vs. Illinois

Monday, Jan. 2, 12 p.m. — While it’s an SEC/Big Ten matchup, it’s not a game featuring either conference’s perennial powers. Still, both the Bulldogs and Illini had excellent seasons and present an interesting matchup for one another. Mississippi State is 8-4 and the poster child for a team with excellent résumé losses to LSU, Georgia and Alabama. It was a team that lost to the teams you’d expect but beat the ones a good team is supposed to beat and finished the year with a win over rival Ole Miss.

Illinois is one of the biggest surprises of 2022. The Illini are 8-4 and making their first bowl appearance since 2019. They got here behind one of the best defenses in the country, and that’s where the matchup gets interesting. Mississippi State will run Mike Leach’s Air Raid offense against an Illini defense that led the nation in defensive passing efficiency at 89.8 (Penn State was second at 104.0). Meanwhile, Illinois’ offense is built on a physical rushing presence led by Doak Walker finalist Chase Brown but faces a Mississippi State team that ranked 47th in EPA per rush on defense. If styles make fights, this will be a fun fight.

9. Alamo Bowl: (20) Texas vs. (12) Washington

Thursday, Dec. 29, 9 p.m. — Here’s the thing about the Alamo Bowl: The matchup is almost always great, but you sometimes run into the problem of the teams not being thrilled to be there because they had been competing for conference titles and fell short. Still, I’m going to take my chances here with a game that offers an incredible quarterback matchup between Washington’s Michael Penix Jr. and Texas’ Quinn Ewers. Penix has the kind of arm strength that will make you gasp at least twice per game, while Ewers routinely flings balls on a rope with a simple flick of his wrist. I hope both play and play well because, if they do, we’re in for a treat.

As for motivation, I know this was a disappointing season for Texas seeing they missed out on playing for the Big 12 title, but it’s a young team that can benefit from playing an opponent like this. Plus, let’s not forget that Texas coach Steve Sarkisian used to coach at Washington, so I’m sure he’ll do everything he can to keep his team’s attention on this game. As for the Huskies, they’re already playing with house money, as nobody was expecting this team to be 10-2 in Kalen DeBoer’s first season. A win would give the Huskies their first 11-win season since they reached the College Football Playoff in 2016.

8. LA Bowl: Washington State vs. Fresno State

Saturday, Dec. 17, 3:30 p.m. — Have you ever seen Fresno State QB Jake Haener? He’s an amalgamation of every underdog quarterback you’ve seen in a movie or television show about a football team. Haener is listed as 6-foot-1 and 201 pounds, which might be generous. Still, Haener is a gamer regardless of size. I’ve seen this kid take so many shots during his career, but he gets up every time and keeps going. Sometimes he gets up slower than others, and sometimes he moves gingerly, but he gets up every time. I love him. He’s the heart and soul of this Fresno State team that won the Mountain West.

I also love Washington State QB Cam Ward, who transferred to Wazzu from Incarnate Word before the season. He didn’t put up the same numbers in the Pac-12 that he put up there, but he’s an entertaining watch on a tough Washington State team. The Cougars lost five times this year, but the five losses came to Oregon, USC, Oregon State, Utah and Washington — teams that were a combined 49-11. It’s a better team than its 7-5 record indicates, and I like this game’s chances of being entertaining.

7. Las Vegas Bowl: (14) Oregon State vs. Florida

Saturday, Dec. 17, 2:30 p.m. — The Pac-12 got a lot of attention this year thanks to solid seasons from USC, Oregon, Washington, Utah and UCLA, but Oregon State still managed to fly under the radar despite having just as good of a season! The Beavers went 9-3 and nearly knocked off USC and Washington. Jonathan Smith has done a fantastic job building this program; its win total has increased every season since he took over in 2018, except for the 2020 COVID season. The nine wins the Beavers have already picked up are their most in a season since going 9-4 in 2012, and if they pick up a win here, it’ll be the program’s first 10-win season since 2006.

To get that win, it’ll have to get past a Florida team with a high ceiling. Florida opened the year with a win over Utah, and while it was impressive, it probably raised expectations too quickly. The Gators came back down to earth in SEC play, finishing with a 3-5 mark, and went only 2-4 in the SEC East. The Gators will be trying to pick up a seventh win to finish over .500, but that would have been more likely if QB Anthony Richardson, who was projected by many to be a first-round NFL Draft pick, didn’t decide to skip this game.

6. Holiday Bowl: (15) Oregon vs. North Carolina

Wednesday, Dec. 28, 8 p.m. — Hurry up and bet the over before it gets higher because I can guarantee the total will get higher. The season did not end the way either of these teams hoped it would a month ago. Back then, Oregon was 8-1 with the Pac-12 title and a possible playoff berth in reach. Then the Ducks lost by three at home to Washington, Bo Nix sprained his ankle and the team literally limped to the finish line at 9-3. North Carolina was 9-1 with a QB in Drake Maye whom many were pegging as a future No. 1 draft pick. They were wins against Georgia Tech and NC State away from being 11-1. They then lost to both to fall to 9-3 and finished by getting trounced 39-10 by Clemson in the ACC Championship Game.

These teams are mirror images of one another who reside on opposite ends of the country. Two prolific offenses paired with defenses that can’t stop anybody. Ladies and gentlemen, we might see 100 points scored in this game. You could end up telling your grandchildren about it one day.

5. Cotton Bowl: (10) USC vs. (16) Tulane

Monday, Jan. 2, 1 p.m. — It used to be that we expected the Group of Five champion that earned the New Year’s Six berth to get spanked in the bowl game because that used to be what happened. Then UCF happened, and last year Cincinnati made the CFP. We’ve all wisened up to the idea that these teams need to be taken seriously in spots like this, and USC would be well-served to take Tulane seriously, mostly because USC’s defense shouldn’t take anybody or anything for granted. Did you see those guys try to tackle Utah players in the Pac-12 Championship Game?

The Green Wave won the American thanks to a fun offense and an excellent pass defense, but that defense didn’t come across many passing attacks like USC. Caleb Williams is one of the best QBs in the country and could win the Heisman Trophy this week. He has a cavalcade of weapons surrounding him on offense, and I anticipate the Trojans will put up points. But will the Trojans stop Tulane’s Tyjae Spears? Again, did you see them try to tackle vs. Utah? There’s a good chance this game comes down to the final minutes.

4. Cure Bowl: (24) Troy vs. (25) UTSA

Friday, Dec. 26, 3 p.m. — HIPSTER ALERT! Get ready to be condescending as all hell, folks, because all the people who don’t realize how incredible this game is going to be are not worthy of your time! Oh, you’re a Troy and UTSA fan? Name three of their albums. I’ll wait.

Seriously, it’s a battle of conference champions. UTSA went 11-2 this season to win Conference USA as the Roadrunners have now gone 17-1 in conference games over the last two seasons. They are one of the most entertaining offenses in the country. Frank Harris runs it to perfection, and receiver Zakhari Franklin will catch balls in the NFL soon. Then there’s Troy, which went 5-7 last year but finished 11-2 this year in Jon Sumrall’s first season en route to a Sun Belt title. The Trojans lead with their defense, but don’t think they aren’t capable of putting up points themselves. Trust me, I understand that most of you reading this probably haven’t seen either of these teams play, but take some time out of your schedule to make sure you tune into this game. You won’t regret it.

3. Rose Bowl: (8) Utah vs. (11) Penn State

Monday, Jan. 2, 5 p.m. — I know it’s cool to hate the Rose Bowl these days because it was scapegoated as the only thing standing in the way of the playoff expanding to 12 teams as so many people wanted, but I love the Rose Bowl. I will always love the Rose Bowl. Whether it’s part of the playoff or not, I don’t care. I don’t even need it to have the traditional matchup of Big Ten vs. Pac-12 (though I prefer it). This game has always been near my heart, and it always will be. It’s one of the most beautiful scenes in college football every year, and it tends to have an excellent matchup to go with all the aesthetics.

This year is no different. We have Pac-12 champion Utah — the only team to beat USC (doing so twice) this season — going against Penn State. The Nittany Lions are 10-2, but while their losses were by an average of 18.5 points against Michigan and Ohio State, they dominated everybody else on the schedule. These are two physical, talented football teams likely to put on an epic performance in an incredible atmosphere. Don’t even think of missing it.

2. Fiesta Bowl: (2) Michigan vs. (3) TCU

Saturday, Dec. 31, 4 p.m. — The Fiesta Bowl provides a matchup of two teams that are more similar than you assume because of the style they prefer to play. TCU is a spread offense with a lot of Air Raid elements offensively, but running the ball is still fundamental to everything the Frogs do offensively — much like the Michigan offense, which is seen as the old-school, smash-mouth offense often associated with the Wolverines and the Big Ten.

The biggest difference this season is that TCU has been far more explosive through the air than Michigan, but the Wolverines have begun to show flashes in that department in recent weeks. Still, the key will be what these teams do in the red zone. Both have struggled to finish drives with touchdowns at times this year, and it’s made some games more difficult than they had to be. The team that does the better job here will win and move on to the title game.

1. Peach Bowl: (1) Georgia vs. (4) Ohio State

Saturday, Dec. 31, 8 p.m. — If this isn’t a battle of heavyweights, then what is? Sure, some people are mad at Ohio State being chosen for the College Football Playoff despite getting beat handily at home by Michigan to finish the regular season, but ignore that. Look at this matchup for what it is. It’s a game between the defending champion with an elite defense against one of the most talented teams in the country filled with future NFL players.

If you can’t get excited about watching QB C.J. Stroud and Ohio State’s receiving corps going against the Georgia defense, what are you even doing reading these rankings? This is precisely the kind of game you dream of seeing when you watch college football. Playoff game or not, it’s a banger.

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Cancer vaccine ‘cure’: Three terminal patients put in remission by experimental shot

After a 20-plus-year battle with cancer and 12 brutal rounds of surgery and treatment, Stephanie Gangi was ready to give up.

When doctors found a new tumor the size of a grapefruit on her adrenal gland last summer, neither her mind nor body could take another course of chemotherapy. 

To the shock of her two daughters and healthcare providers, the novelist, 66, declined further medical treatment. ‘I decided to see what happens; just take my chances,’ she told DailyMail.com. 

‘My doctor, of course, hated that answer and so the next day called me and said, “there’s a clinical trial starting and I think it would be great for you.”’

Ms Gangi was put on a last-resort trial in New York for patients whose cancers have spread around the body and become virtually incurable, known as ‘metastatic’. 

She was one of 10 patients in the study, alongside William Morrison, 53, and Anna Bochenski, 51, who are either in partial or complete remission, despite being given just years to live.

They were given a vaccine — developed at the famous Mount Sinai hospital in Manhattan, New York — that rapidly melts away the primary tumor and teaches the body to hunt and kill cancer cells that have spread elsewhere.

Stephanie Gangi, 66, (pictured left) had a tumor on her chest, and stopped wearing t-shirts as a result. ‘Being injected into that tumor was ‘pretty harrowing’, she said. William Morrison, 53, (pictured right) with his beloved dog after the clinical trial was over

Ms Gangi was given the injection directly into the large tumor that protruded from her sternum. The tumor had prevented her from wearing tops that showed her chest for years.

Within two months, the mass was completely flattened, and she celebrated being completely cancer-free at her daughter’s wedding earlier this year.

She said: ‘It’s hard to even wrap my head around it. I have had cancer for a very long time so it’s not just snap my fingers and have it not be present for me. I do get the same old “scanxiety” when I’m due for a test.’

‘I keep wondering, did it really work? Is it coming back? What’s happening? …But I feel great and am very grateful,’ Ms Gangi said. It is the first time in over ten years she has been medication-free.

Dr Thomas Marron — who is part of the team that have devoted the last decade to creating the vaccine — said ‘it was like winning the lottery’ when he saw the scan showing Ms Gangi’s adrenal tumor had gone. 

He added: ‘That was the tumor that most likely would eventually have taken her life.’ 

People diagnosed with metastatic cancer often have very poor survival chances. With some cancers, the five-year survival rate is just six percent, according to the Mayo Clinic. The vaccine is injected directly into tumors, meaning only patients with external cancerous masses can currently benefit. 

It contains a higher dose of a naturally occurring protein that rapidly multiplies levels of dendritic cells in the body – also known as ‘professor’ cells. They kill the tumor and teach T cells in the body to be on the lookout for rogue cancer cells that have spread elsewhere.

The new vaccine is among hundreds of experimental cancer vaccines and medicines in early trials.

The vaccine therapy has four components. Firstly, four small doses of radiation over two days kill some of the tumor cells. This creates dead matter — an essential element for most vaccines. The patient is then injected with Flt3 ligand (Flt3L) to increase the number of ‘professor’ cells produced by the body and a fake virus to switch on the ‘professor’ cells. They will destroy the tumor cells and teach the T cells what to be on the lookout for. The T cells will then look for other tumor cells in the body

How does the new cancer vaccine work? 

The vaccine is injected into an existing tumor in the patient’s body, and teaches the immune system to recognize and kill not only that tumor, but also tumors elsewhere in the body.

The treatment is made up of four components.

First, patients receive four small doses of radiation over two days to kill some cancerous tumor cells.

This creates the dead matter — a key part of most vaccines – so it can learn how to fight the real thing.

They also receive an injection of Flt3 ligand (Flt3L) into their tumor daily for nine days.

This is a protein naturally made by humans every day to make various cell types, including ‘professor’ cells. 

Patients receive a ramped-up dose, meaning the protein can make ten to a hundred times more dendritic cells or ‘professor’ cells. 

Patients’ tumors are injected with poly-ICLC, a fake virus that activates the ‘professor’ cells, eight times over six weeks.

The ‘professor’ cells will gobble up the tumor, and then teach the T cells what to be on the lookout for.

With the knowledge of spotting and killing patient’s tumors, the T cells will travel around the body and destroy any other tumor cells they come across.  

On day 23, patients start to receive the final component, pembrolizumab, given every three weeks for eight treatments.

This is an FDA-approved immunotherapy treatment, which takes the brakes off the body’s immune system and allows it to kill tumor cells. 

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Some utilize mRNA technology pioneered during the Covid pandemic and involve a unique shot that are entirely individualized and made from scratch for each patient. These can take months to make and cost around $100,000 per shot.

But the Mount Sinai candidate uses the same vaccine for each patient, meaning once doctors have perfected the shot, it can be rolled out to the mass market.  

The chemicals involved are also cheap to make. Dr Brody said: ‘The ones we use cost pennies to dollars.’ Although technically a vaccine, the treatment in its current form is given in 17 doses and alongside eight immunotherapy injections.

Dr Brody and Dr Marron hope to reduce the number of shots given to patients in the coming months.

After receiving the experimental vaccine, two other patients — Mr Morrison and Ms Bochenski — have also gone into complete and partial remission.

Mr Morrison, a clinical technician from New York, was diagnosed with blood cancer in 2017.

Things turned for the worst in 2018, when his cancer became more aggressive and spread to his groin and neck.

He had been enrolled in a trial of an earlier version of the Mount Sinai vaccine but did not respond. The father-of-two was put into remission briefly with chemo in 2019, but the cancer returned just as the pandemic hit.

Feeling ‘disheartened’ by the new diagnosis, he agreed to trial a new and improved version of the experimental shot in the summer of 2020. Within six months, his tumors had cleared entirely.

Mr Morrison has been in remission ever since, and said it felt like ‘the weight had been lifted from my shoulders’.

Ms Bochenski was struck with breast cancer in 2014, and embarked on rounds of chemo and surgery. In 2018, a tennis-ball-sized tumor appeared in her armpit, and the cancer also spread to her chest lymph nodes.

Her side effects from the cancer vaccine in January 2021 were intense and left her ‘trembling to the point that I couldn’t hold a cup of tea’.

But the tumor under her arm disappeared and the treatment put her in partial remission.

Ms Bochenski said: ‘If I didn’t take the clinical trial, I would have been dead in 2021.’

The new vaccine is not for the faint-hearted. In total, patients receive 17 injections into the tumor, and a further eight into their arm over six months.

Anna Bochenski, 51, (pictured left) after she had been through six months of fortnightly chemotherapy and a double mastectomy in November 2014. She is pictured on the right in 2012, two years before she was diagnosed with breast cancer

The therapy is split into four phases.

First, patients receive four small doses of radiation over two days to kill some cancerous tumor cells. 

This creates dead matter in the tumor site. Dr Marron told DailyMail.com: ‘You use that to create a vaccine that will hopefully teach your immune system to recognize and kill not only that tumor you’re treating but also tumors elsewhere in the body.

‘If you think about the flu shot. The flu shot has two things in it. It has dead flu. This is basically the thing you’re trying to teach your immune system to recognize and kill. So it kills it right now but it also develops the memories that protect you from flu for the rest of your life.’ 

The treatment consists of administering a series of immune stimulants directly into one tumor site.

The first stimulant recruits critical immune cells called dendritic cells that act like generals of the immune army. 

The second stimulant activates the dendritic, or ‘professor’ cells, which then instruct T cells, the immune system’s soldiers, to kill cancer cells and spare non-cancer cells. 

This immune army learns to recognize features of the tumor cells so it can seek them out and destroy them throughout the body, essentially turning the tumor into a cancer vaccine factory. 

With the knowledge of how to spot and kill patient’s tumors, the T cells will travel around the body and destroy any other tumor cells they come across.  

On day 23, patients receive the final component, pembrolizumab, given every three weeks for eight treatments.

This is an FDA-approved immunotherapy treatment, which takes the brakes off the body’s immune system and allows it to kill tumor cells. 

Dr Brody said they are looking at ways of reducing the number of vaccines, so they could give one injection that would be the equivalent of nine.

Stephanie Gangi’s pre-vaccine scan (pictured left) showed a large tumor on her adrenal gland, which Dr Marron said would most likely have eventually ‘taken her life’. Ms Gangi’s post-treatment scan showed the tumor had completely melted away. Dr Marron said seeing the scan was ‘like winning the lottery’

Seven of the ten patients enrolled on the trial did not respond. But the vaccine is still in its early stages, meaning the doctors have time to perfect the shot and are still very pleased with the trial’s results.

The next step is to collate and examine all of the responders’ tests to see if they can determine why it worked for some patients and not others.

As well as Mr Morrison, the doctors believe Ms Gangi may be in complete remission. But they cannot be certain because her scan still shows a small mass, which the doctors believe is just scar tissue.

Dr Marron said: ‘[Ms Gangi] had a huge tumor. The vaccine was administered to a tumor on her sternum and chest. The thing that we were worried about wasn’t this tumor that was growing out of her chest. 

‘She didn’t like it, because it meant she couldn’t wear shirts that showed any of her chest.’

He added: ‘The thing that we were most worried about was that she had a tumor, the size of a grapefruit in her adrenal gland, right next to her stomach, and that is the tumor that most likely was very painful for her. 

‘And that was the tumor that most likely would eventually have taken her life.’ 

After she received the vaccine treatment, he said: ‘By the time that we did the first PET scan, the tumor on the adrenal gland was gone entirely. 

‘To this day, she’s in remission, and she really doesn’t have any sites of active disease.’

But Dr Brody said his vaccine is ‘profoundly safer’ than other cancer therapies.

He told DailyMail.com: ‘There’s not too many cancer therapies we use that have a precedent of melting away large tumors and have almost no side effects.

He noted that the main side effect, a fever that lasts about a day, is ‘similar to the Covid vaccine’.

Dr Marron said: ‘Most patients will have received chemotherapy in the past, especially the breast cancer and the head and neck patients.

‘Chemo is much more toxic to the whole body but particularly to the immune system. Immunotherapy is like the opposite of chemotherapy in that chemotherapy really steps on your immune system and immunotherapy really revs up your immune system.’

Stephanie Gangi, 66, who was ‘ready to give up’ after 23-year cancer battle

Author Stephanie Gangi had tried 12 different types of treatment, but nothing would completely shift her cancer

In her mid-40s, Stephanie Gangi was diagnosed with breast cancer from a routine mammogram.

She cycled through 12 different treatments, undergoing surgery, radiation and chemotherapy. ‘I became the poster child for chronic illness,’ she told DailyMail.com.

These treatments put her into remission for ten years, but her cancer returned in 2011 and became metastatic, spreading to the bone and chest wall in 2014. She had a couple more rounds of chemotherapy.

In the summer of 2021, a tumor the size of a grapefruit appeared on her adrenal gland.

Ms Gangi said: ‘This time it was a little bit more distressing… This time it moved to my adrenal gland and that was the more distant metastases. It was on the move.’

In the middle of publicizing her latest book, her only option was another round of aggressive chemotherapy.

She said: ‘I thought it over and I talked to my kids and I said, I’m 66 and I’ve been dealing with this for so long and I’ve done every single thing successfully and it’s kept me going for 20-plus years.’

Ms Gangi decided not to do chemotherapy again and ‘see what happens, just take my chances, even for just six months’.

She was injected into a tumor on her sternum, where the most active cancer was.

She said: ‘I had a tumor that was starting to show on my chest, so much so that I would no longer wear a t-shirt. Maybe the average person didn’t notice it, but I noticed it.

‘[Getting injected into the tumor] was pretty harrowing, I’m not going to lie. But I did notice after about 90 days that the tumor had flattened. That’s when we knew I was having a positive response to the immunotherapy protocol.’

Ms Gangi celebrating after the vaccine trial ended on the weekend of her daughter’s wedding in Oakland, California

Ms Gangi said the side effects were ‘terrible’ and ‘I wanted to quit a million times’.

She said: ‘The fatigue was profound. A couple of days after treatment, I had classic flu-like symptoms, a fever, chills, complete body aches and zero motivation.’

But intense side effects were not all bad.

‘The suspicions were that the more robust the side effects, the better. That your body was really working to fight that. So I held on to that. And that has proved to be true,’ she said.

Ms Gangi at home with her dog in New York. She tried to keep things as normal as possible and continued working throughout her cancer treatment, but she said the fatigue from the vaccine therapy was ‘profound’

The trial therapies melted away Ms Gangi’s adrenal gland tumor and erased the cancer from the rest of her body. A small bump remains on her sternum, but doctors hope it is just a scar left behind from the cancer.

Despite her body’s positive reaction to the treatment, Ms Gangi said she does not feel completely cured.

‘But [the cancer] appears to be gone, which is amazing. It’s hard to even wrap my head around it.’

She added: ‘I have had cancer for a very long time so it’s not just snap my fingers and have it not be present for me. I do get the same old “scanxiety” when I’m due for a test.

‘I’m wondering, did it really work? Is it coming back? What’s happening? …But I feel great and I’m very grateful.’

For the first time in at least a decade, Ms Gangi does not have to take any drugs.

She said: ‘I have no pain so I’m not taking medication for it which is fabulous. I love not having to manage the medication.’

The treatment has meant she can enjoy her life even more: ‘I’ve been able to travel without worrying. 

‘My kids are not worrying for the first time in years. It’s not constantly hovering over me.’

William Morrison, 53, suffered two devastating blood cancer diagnoses

William Morrison was diagnosed in 2017 with a type of blood cancer called follicular lymphoma.

As an initial form of treatment, he took part in Dr Brody’s first clinical trial, but it had little effect.

In early 2018, his cancer transformed into a more aggressive type of non-Hodgkin’s lymphoma.

Mr Morrison had six cycles of chemotherapy in the winter of 2018, which put him into remission for a year.

Just a year later, a scan showed the cancer had come back in a few spots, which he said was ‘disheartening’.

Mr Morrison prior to his cancer diagnosis (pictured left) and during chemotherapy treatment (pictured right)

Mr Morrison during the most recent clinical trial with his dog Luca

Mr Morrison in the summer of 2022 with his wife Lenore, son Brad, Brad’s wife Kelly, his younger son Billy and Billy’s girlfriend Ally

Mr Morrison told DailyMail.com: ‘That was a little disappointing because I thought it would have given me a few years or possibly more.’

He said: ‘That’s when [Dr Brody] mentioned this other, more recent clinical trial, which is similar to the first one that I had but they added some other types of medicine to it, they changed it a little bit.’

He started the second clinical trial in the summer of 2020 and finished it in January 2021, receiving injections in the neck area.

He suffered minor side-effects of flu-like symptoms such as body aches and a high fever.

The vaccine treatment cleared his cancer and he has been in complete remission ever since.

Mr Morrison said: ‘I was pretty relieved, like the weight had been lifted from my shoulders.’

He said: ‘I’m definitely glad that I decided to do it. I had some doubts initially, you hear from other people, “Do you think you should do it? It’s not a proven type of therapy. It’s experimental.” But my doctor told me I had nothing to lose.’

He added: ‘I’m happy that I pushed through it, and I would encourage anybody who’s in a similar situation to do it, because I’m two years out now in remission.’

Anna Bochenski, 51, was given only three years to live

Ms Bochenski said the vaccine therapy saved her life

Anna Bochenski was first diagnosed with breast cancer eight years ago at the age of 43.

She had surgery to remove a tumor in her right breast, but the cancer came back in a nearby spot just a couple of weeks later.

Ms Bochenski began fortnightly chemotherapy, followed by a double mastectomy.

In January 2015, she had radiation every day — a total of 32 sessions which left her cancer-free.

Three years later, she began to feel pain in her right ribs, and doctors discovered she had stage four terminal cancer in her ribs, spine and armpit — where she had a tumor the size of a tennis ball.

Doctors told her she had just three years to live. ‘It was pretty traumatic,’ she told DailyMail.com.

She said: ‘I went through every possible chemo. In December 2020 we learned that my cancer is not responding to any treatments, and this is it.’

In January 2021, she enrolled on the clinical trial and finally started seeing a positive change.

‘The tumor under my arm is completely gone,’ she said.

Her spine tumor has also cleared, and the one in her ribs has significantly shrunk. Most importantly, the cancer is not spreading.

With stage four terminal cancer, Ms Bochenski doesn’t think she will ever be able to stop taking a chemotherapy drug, but thanks to the clinical trial, ‘everything is under control’.

But her experience wasn’t completely smooth sailing and she was hit by side effects of the shot.

Ms Bochenski the day before her first chemotherapy in 2014 (pictured left). She chose to shave her head as she didn’t want to experience losing her hair. She is pictured right at Mount Sinai during the clinical trial on her first day of immunotherapy

She said: ‘The day I got injected… [later on] I was trembling to the point that I had such a shivery reaction, my hands were shaking. I could not hold a cup of tea or bottle of water.

‘I called Dr Marron and said I think I’m dying because I’ve never felt anything like this. My body went crazy. It lasted for two or three hours.

‘The shivering was so intense that I was worried that I was going to bite my tongue with my teeth. It freaked me out completely.

Ms Bochenski said the vaccine wiped her out for three days, after which she felt better and could return to work.

She said she would ‘absolutely’ recommend the treatment to a friend, adding: ‘If I didn’t take the clinical trial, I would have been dead in 2021.’

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UK researchers cure man with persistent Covid for over a year

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Researchers in Britain say they have used genetic sequencing to help cure a man who was infected with the coronavirus for more than 411 days.

The 59-year-old patient, who had a weakened immune system due to a kidney transplant and the use of an immunosuppressant drug, initially tested positive in December 2020.

After further tests in February 2021 and January 2022 came back positive, the team in London carried out a genetic analysis of the virus, which showed that the same strain was present at each stage, with only minor variations — meaning that the patient was suffering from a chronic coronavirus infection, rather than multiple new infections.

Chronic coronavirus infection is distinct from long covid, in which people suffer from persistent symptoms and long-term effects after being infected with the virus that causes covid-19.

“Nowadays, everyone is infected with omicron, but when we looked at his virus, it was something that existed a long time ago — way before omicron, way before delta and even before alpha. So it was one of those older, early variants from the beginning of the pandemic,” Luke Blagdon Snell, a specialist in infectious diseases and a researcher on the case, told The Washington Post on Friday.

Because the patient was experiencing only mild or intermittent symptoms, he had been ineligible for treatments used to prevent or treat severe covid.

The results of the genetic sequencing showed that the man had been infected with the B.1.177.18 coronavirus variant, which was present in Britain in late 2020. The team was therefore able to give the patient a combined antibody treatment shown to be effective against that strain.

The case was among several highlighted by Snell and the team of researchers from Guy’s and St Thomas’ NHS Foundation Trust and the Department of Infectious Diseases at King’s College London in a preprint article published in the peer-reviewed Clinical Infectious Diseases journal on Thursday.

Although the more-recent variants now dominant in Britain do not respond to the antibodies used in this case, the findings show the potential for individualized therapies in patients with chronic coronavirus infections. The process of genome sequencing outlined in the paper offers results within 24 hours, allowing medical teams to respond quickly to patients’ needs.

In two other cases highlighted in the report, genetic sequencing showed that patients suspected to be suffering from prolonged infection had in fact been reinfected with a newer strain of the virus. Their doctors were therefore able to alter their treatment plans accordingly.

Genome sequencing has been used throughout the pandemic to identify new variants and sub-strains, such as omicron, which was first detected by scientists in southern Africa in November 2021.

Scientists have a powerful new tool for controlling the coronavirus: Its own genetic code.

It is unclear how prevalent chronic coronavirus infections are. The longest case known to date was in a patient who tested positive for 505 days before dying and was treated by the same teams.

“But there’s definitely a difference between a normal community infection which resolves within two weeks,” as happens in most cases, and the small proportion of immunocompromised patients who are at risk of a chronic infection lasting more than six weeks, said Snell.

Among persistent infections, he said, there are two groups: those, like the man who was cured, who are relatively asymptomatic, and others who face more-serious outcomes.

Any long-term infection will affect the body, but even asymptomatic cases can prove dangerous: “We do know that some people, even after several months, if they have this persistent infection, can deteriorate at a later date.”

And even though cases of chronic infection are rare, high levels of infection mean that vulnerable patients are more likely to be infected and potentially develop chronic infections, he added.

The aim of future research in this area is to collect enough data on persistent infections to identify new treatment options — an issue that has become all the more important given new variants’ increasing resistance to antiviral treatments, Snell said.

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Cure for baldness could be on horizon as Japanese researchers generate mature hair follicles in lab

Scientists in Japan have successfully grown mature hair follicles in a laboratory — something researchers hope can lead eventually to effective treatments for baldness and other conditions. 

A team of scientists from Japan’s Yokohama National University published the study in the journal Science Advances on Friday.

Their journal article, titled “Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction,” described their use of embryonic mouse cells to create a hair follicle that grew 3mm (approximately 0.12 of an inch) over 23 days. 

THESE TREATMENTS CAN HELP COVID-19-RELATED HAIR LOSS, DOCTORS SAY

The scientists said in a press release that they believed their research “could prove valuable for better understanding of hair follicle induction, for evaluating hair pigmentation and hair growth drugs, and for regenerating hair follicles.”

The new developments out of Japan marked the first time a mature hair follicle had been grown in a lab, researchers said.
(iStock)

“Our next step is to use cells from human origin, and apply for drug development and regenerative medicine,” Junji Fukuda, a professor and member of the faculty of engineering at Yokohama National University, said in the release. 

The study marked the first time a mature hair follicle had been grown in a lab, they noted.

“This new understanding of how cells interact can hold much larger implications for understanding and correcting defects in other tissues …”

While the development holds “great potential” for those with baldness, there are other reasons to be excited about this research, Dr. Michael Kinch, a cell biologist and cancer researcher based at Long Island University’s Center for Research Innovation in Biotechnology, told Fox News Digital via email.

DRUG TO TREAT ALOPECIA APPROVED BY THE FDA

“This new understanding of how cells interact can hold much larger implications for understanding and correcting defects in other tissues that contain similar types of cells,” said Dr. Kinch, who was not involved in the research, “ranging from diabetes (where similar interactions control insulin production) to cancer.”

Kinch said that he had studied the roles of epithelial-mesenchymal cell interactions earlier in his career — and that “a better understanding of these relationships likely determines the potential that cancer might arise,” which could lead to a better cancer progression. 

This, however, will take a considerable amount of time. “The field is progressing, but not fast enough,” he said.

“This research shows how far we have come with manipulating embryonic cells and the breadth of medical applications this technology can have,” said one internist in the Washington, D.C., area.
(iStock)

Dr. Ken Zweig, an assistant professor of medicine at Georgetown University and George Washington University medical schools in Washington, D.C., told Fox News Digital, “The research is interesting, but I would think we are a long way off from this being a cost-effective application.”

He added, “Using stem cells is controversial and expensive, which limits this from having widespread availability any time soon.”

Zweig also noted, “Plus, we already have relatively cheap, safe and somewhat effective treatments for hair loss already, including Rogaine, Propecia and hair transplants.”

“Other advancements in hair regrowth have shown promise.” 

However, he also said, “the technology is very exciting — this research shows how far we have come with manipulating embryonic cells and the breadth of medical applications this technology can have.”

Micro-injection of molecules

While lab-grown hair follicles are likely years away from reaching a bald person’s head, as the researchers note, other advancements in hair regrowth have shown promise. 

A micro-injection of a molecule called “SCUBE3” triggered hair growth in mice that had dormant hair follicles, according to University of California, Irvine researchers, who published their findings in the medical journal Developmental Cell in June.

The molecule even worked on human hair follicles that had been grafted onto mice, the study reported. 

However, similar to the lab-grown follicles, it will likely be years before humans will be able to receive these treatments. 

Medication for hair loss

One thing that is available in present day, albeit without FDA approval for hair loss, is a pill form of the drug Minoxidil. 

WHY CAN CHRONIC STRESS RESULT IN HAIR LOSS? NEW RESEARCH PROVIDES CLUES

While Minoxidil is approved by the FDA for topical use for the prevention of hair loss, scientists discovered years ago that a low-dose oral version of the drug is also effective at preventing hair loss and encouraging regrowth, The New York Times reported back in 2018.

Minoxidil is the active ingredient in Rogaine, a medication for hair loss that has been approved by the FDA since the late ’80s, the same publication said.

For many men, hair loss is tied to masculinity issues, according to aesthetics nurse practitioner Wendy Vaughn.
(iStock)

A study involving high doses of oral Minoxidil for high blood pressure resulted in many patients also reporting increased hair growth, they noted.

Also, a 2017 study published in the International Journal of Dermatology found that “once-daily capsules containing minoxidil 0.25 mg and spironolactone [a diuretic] 25 mg appear to be safe and effective in the treatment” of female pattern hair loss.”  

CHEMICAL HAIR-STRAIGHTENING PRODUCTS MAY INCREASE UTERINE CANCER RISK: NIH STUDY

Dr. Rodney D. Sinclair, a professor of dermatology at the University of Melbourne, found that of the 100 women in the study, only eight experienced “generally mild” side effects. 

Of those eight, only two elected to cease treatment, according to the study.

‘Tied into masculinity’

Baldness is more than just losing hair, Wendy Vaughan, an aesthetics nurse practitioner based in Woburn, Massachusetts, told Fox News Digital via email.

For many men, their hair “is tied into their masculinity,” she said, while some women with thinning hair “feel self-conscious and feel the need to try and address the issue.”

Treatments such as lab-grown follicles would be a “game changer” for those who are upset about their thinning hair, she said.

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Vaughan cautioned that existing hair loss treatments can sometimes come with severe side effects. 

“Propecia’s active ingredient (finasteride) has the ability to block the hormone responsible for male pattern baldness, but it can also have some damaging effects pertaining to a man’s sexual health,” she said. 

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“Most commonly,” she said, is “loss of libido and erectile dysfunction.” 

Amy McGorry contributed reporting to this article. 

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A bold effort to cure HIV—using Crispr

Enlarge / A 3D illustration of the HIV virus.

In July, an HIV-positive man became the first volunteer in a clinical trial aimed at using Crispr gene editing to snip the AIDS-causing virus out of his cells. For an hour, he was hooked up to an IV bag that pumped the experimental treatment directly into his bloodstream. The one-time infusion is designed to carry the gene-editing tools to the man’s infected cells to clear the virus.

Later this month, the volunteer will stop taking the antiretroviral drugs he’s been on to keep the virus at undetectable levels. Then, investigators will wait 12 weeks to see if the virus rebounds. If not, they’ll consider the experiment a success. “What we’re trying to do is return the cell to a near-normal state,” says Daniel Dornbusch, CEO of Excision BioTherapeutics, the San Francisco-based biotech company that’s running the trial.

The HIV virus attacks immune cells in the body called CD4 cells and hijacks their machinery to make copies of itself. But some HIV-infected cells can go dormant—sometimes for years—and not actively produce new virus copies. These so-called reservoirs are a major barrier to curing HIV.

“HIV is a tough foe to fight because it’s able to insert itself into our own DNA, and it’s also able to become silent and reactivate at different points in a person’s life,” says Jonathan Li, a physician at Brigham and Women’s Hospital and HIV researcher at Harvard University who’s not involved with the Crispr trial. Figuring out how to target these reservoirs—and doing it without harming vital CD4 cells—has proven challenging, Li says.

While antiretroviral drugs can halt viral replication and clear the virus from the blood, they can’t reach these reservoirs, so people have to take medication every day for the rest of their lives. But Excision BioTherapeutics is hoping that Crispr will remove HIV for good.

Crispr is being used in several other studies to treat a handful of conditions that arise from genetic mutations. In those cases, scientists are using Crispr to edit peoples’ own cells. But for the HIV trial, Excision researchers are turning the gene-editing tool against the virus. The Crispr infusion contains gene-editing molecules that target two regions in the HIV genome important for viral replication. The virus can only reproduce if it’s fully intact, so Crispr disrupts that process by cutting out chunks of the genome.

In 2019, researchers at Temple University and the University of Nebraska found that using Crispr to delete those regions eliminated HIV from the genomes of rats and mice. A year later, the Temple group also showed that the approach safely removed viral DNA from macaques with SIV, the monkey version of HIV.

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Kanye West relaunches his political ambitions and vows to CURE cancer

Kanye West has said he is open to returning to politics, insisting that he had not been put off by his failed presidential bid in 2020.

The rapper, whose father battled stomach cancer in 2018, said that he intended to work to cure the disease.

He said he would work on promoting ‘fresh air and food’. 

In October 2018, West said his father Ray’s cancer was in remission, and he was embarking on a strange diet to celebrate. 

‘Overcome fear,’ Kanye captioned an Instagram photo showing the insects. ‘My dad and I are going to eat this plate of bugs to celebrate him beating cancer. No more fear.’ 

He discussed in the wide-ranging interview his co-parenting with ex-wife Kim Kardashian, saying they clashed on certain issues, but worked to resolve them. 

Asked on Thursday if he had future political aspirations, West replied: ‘Yes, absolutely.

‘You know, that time wasn’t in God’s time. I’m sure there are lives that were saved.

‘I’m sure God had me fall on the sword and say this is not the time,’ he told ABC News on Thursday night. 

‘But he’s a redeemer. He’s given me this oxygen, he’s given me this platform, he’s put amazing people around me.

‘He’s given me new purposes. A new lease on life. New air to breathe. And a new respect.’

He added that he was spending time with Jared Kushner. 

Kanye West has spoken to ABC News, in an interview that previewed on Thursday night

‘His brother said he’d kill him if he went back to the White House. That’s the answer,’ West replied, when asked whether that was a genuine friendship or a political move.

West said he had met the mayor of Miami, Francis Suarez, and thought ‘he would make a really good president, also.’

Linsey Davis asked: ‘In addition to you?’

West replied with a smile. 

Davis asked him whether he thought social media was helpful or harmful to him.

In a series of Instagram posts last month, the rapper – who has been open in the past about his bipolar disorder diagnosis and ongoing struggles with mental illness – accused Kardashian of trying to control their children’s lives and schooling. 

West said he thought social media could be helpful and harmful. 

‘That’s one of my favorite questions of this interview,’ West said. 

‘We can use a car to rush somebody to the hospital. Or we could use a car and accidentally hit somebody while we’re rushing somebody to the hospital.

‘It’s all about how we use it.’ 

West, 45, was asked by Linsey Davis about his relationship with social media

Davis asked whether he felt social media was helpful or harmful to him

West and Kardashian have four children together: North, Saint, Chicago and Psalm

West was asked about his parenting style, and what it was like to co-parent with his ex-wife Kim Kardashian.

She filed for divorce in February 2021, and their separation was finalized in June this year.

The couple share four children – daughter North, nine; six-year-old son Saint; daughter Chicago, four, and three-year-old son Psalm.

‘I have a voice, and I don’t agree with certain things, as a dad and as a Christian,’ he said.

‘I have a right to have a voice on what my kids are wearing, what they are watching, what they are eating.’

His comments come weeks after he accused his ex-wife and Hulu, the Kardashian family’s streaming giant partner, of railroading him when choosing where the kids go to school. 

He compared himself to a sperm donor, arguing that he had been left without a say, and fumed over the fact that the children were attending an expensive private school in Los Angeles when he wanted them to go to his school, the Donda Academy, set up in honor of his late mother.  

‘I have a platform, and I get to say what so many dads can’t say out loud. There are so many situations where an entire family can go and basically take control of the kids.

‘I know so many people that hit me, like, out of Chicago, and say: yo, I just went through the same thing as you.

‘People will call me and say hey, are you OK? And I’m like, well I’m OK now because I said something. But I wasn’t OK before with the situation, and that’s why I said something.

Kardashian dated comedian Pete Davidson after her split from West. The pair parted ways earlier this year 

‘And there are little nuances of what was happening before at Gap. What was happening at Adidas. And what was happening at home.

‘It was all something of a disregard for what I co-created.

‘I co-created the children. I co-created the product at Adidas. I co-created the product at Gap. 

‘And I let everyone know that there is actually a through-line, a parallel.

‘And that does touch on discrimination.’

He accused Kardashian, in a conversation he shared on Instagram, of disrespecting him because she is ‘half white’. 

‘Y’all don’t have so so over my black children and where they go to school,’ he wrote in one message. 

The Chicago-born musician and businessman, however, said on Thursday he had a ‘new respect’ for Kardashian, and that he always wanted her to be ‘calm’. 

‘This is the mother of my children, and I apologize for any stress that I have caused, even in my frustration, because God calls me to be stronger,’ he said. 

‘I need this person to be less stressed and of the best, sound mind and as calm as possible to be able to raise those children at the end of the day.’ 

 West posted screenshots of his text conversations with his ex-wife where she begged him to stop mentioning her mother, Kris Jenner, and to stop airing their dirty laundry

He wrote something resembling a poem that alluded to the Kardashians on Hulu while speaking more about his mental health and his children’s school

‘Whatever I’m doing, it’s not working’, Kim joked of her approach to romance during a recent appearance on James Corden’s Late Late Show 

At Donda, he said children ‘spread’ and ‘sing’ the gospel.  

He added that his aim was ‘to build a school that gives kids practical tools that they need in the world.’ 

He said, in an interview earlier this month, he wanted children to learn about space travel in a ‘shoutout to Elon Musk’. 

‘We have to allow for self-confidence. So many schools take away from the confidence that these future leaders have for themselves. 

‘Those less confident leaders lead on lying, as opposed to leading on the truth first.

‘We have to educate the critical mass on esteem, on religions – all the religions. We have to educate the critical mass on yoga, financial literacy, we have to expose information. 

‘We have to educate on physics – how do things actually work? How do pipes and water actually work? Our school is around engineering.’

Photos exclusively obtained by DailyMail.com last week show the eerie campus that was deserted in the middle of the day on September 14, a Wednesday. 

There were no cars in the parking lot and no signs of life. 

The school, that aims to provide a Christian education, could have been observing the Exaltation of the Holy Cross, a saints day celebrated on September 14 that commemorates the discovery of the cross that Jesus Christ was crucified on. 

There are around 100 students enrolled at the school in addition to 16 full-time teachers. It’s unclear where they were on the day the pictures were taken. 

West was in New York City on September 14, at Fashion Week. 

Photos exclusively obtained by DailyMail.com show the eerie campus that was deserted in the middle of the day on September 14, a Wednesday

Little was known about the school until Rolling Stone published an expose. The school is named for West’s mother, Donda

On the school’s website, the Donda Academy says its goal is ‘to provide youth with the passion, purpose and spiritual foundations they need to thrive in tomorrow’s world

The website describes the school as providing students with ‘a world-class education that includes a rigorous core curriculum, and an emphasis on sustainability, creativity, critical thinking and problem solving

West is seen leaving the VOGUE World: New York during September 2022 New York Fashion Week on September 12

Little was known about the school until Rolling Stone published an expose. 

The school is named West’s mother, Donda. 

On the school’s website, the Donda Academy says its goal is ‘to provide youth with the passion, purpose and spiritual foundations they need to thrive in tomorrow’s world.’

The website describes the school as providing students with ‘a world-class education that includes a rigorous core curriculum, and an emphasis on sustainability, creativity, critical thinking and problem solving.’ 

The school teaches pre-K through to 12th grade. Tuition for the school costs $15,000 per year. Around half of the students are receiving financial aid. 

Among the students is singer Keyshia Cole’s son Daniel. 

West said on Thursday that he was continuing his legal fight with Adidas and Gap

On Thursday, West vowed to continue with his legal fight with Adidas and Gap, saying: ‘We got new lawyers…we really had to level up and really show them who’s the new boss in town.’ 

He was confronted with the infamous 2013 video of him unleashing on journalist Sway Calloway, who asked him, in a radio interview, why he didn’t launch the clothing and shoe brand alone. 

West replied angrily: ‘You don’t got the answers, Sway!’ 

On Thursday, he relented, that he had been right all along. 

‘You know what, I’d go ahead and say Sway had the answer. People are gonna be like ‘no!”

He said he now intends to sell Yeezy products direct to consumers. 

During the ABC interview, he said he thought people believed he was ‘crazy’ because of his faith.

‘When I finally go to heaven and get to talk to God, I’m going to say: why did you let all these people think I was so crazy?

‘And God is going to say, well, it was a camouflage. I was protecting you.’ 

West has been open in the past about his bipolar diagnosis. 

In a candid 2019 interview with David Letterman for his Netflix show My Next Guest Needs No Introduction, he explained how he felt during manic episodes. 

‘You have this moment [where] you feel everyone wants to kill you. You pretty much don’t trust anyone. 

‘When you’re in this state, you’re hyper-paranoid about everything, everyone. 

‘This is my experience, other people have different experiences. Everyone now is an actor. Everything’s a conspiracy. 

‘You feel the government is putting chips in your head. You feel you’re being recorded. 

‘You feel all these things.’ 

At the time, he advocated for taking daily medication. 

‘If you don’t take medication every day to keep you at a certain state, you have a potential to ramp up and it can take you to a point where you can even end up in the hospital. 

‘And you start acting erratic, as TMZ would put it.’ 

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A Potential Basis for a Cure for Coronavirus Found

Summary: The compound Salen effectively binds to a number of SARS_CoV_2, the virus that causes COVID-19, proteins. The findings pave the way for developing new therapeutics to fight coronavirus.

Source: URAL Federal University

Researchers found out that salen is able effectively bind a number of proteins of the coronavirus SARS-CoV-2.

Scientists used the method of molecular docking and discovered, that salen shows activity to the non-structural protein nsp14, which prevents the destruction of the virus.

The new finding can be useful for new drugs creation and effective treatments for coronavirus infection.

The results of the study are published in the Polycyclic Aromatic Compounds.

“Our study focused on a well-known compound, salen. We tried to assess the potential activity of this compound against a series of proteins of the SARS-CoV-2, which cause the Covid-19 disease.

“We found out that salen can potentially interact with the studied proteins, and the best results were obtained for the non-structural protein nsp14, which protects the virus from destruction”, says Damir Safin, Research Engineer at the Organic Synthesis Laboratory of Ural Federal University.

The term “salen” refers to a tetradentate Schiff base, derived from salicylaldehyde and ethylenediamine. Salen itself as well as its derivatives are important ligands in many fields of practical application.

This is an organic compound which is capable to coordinate some metals, stabilizing them in different oxidation states. Metal complex compounds of salen derivatives are also actively used as catalysts.

As a part of salen contains two “fluid” hydrogen atoms of hydroxyl groups. Each of these hydrogen atoms can move to nitrogen atoms, thereby forming different shapes of the molecule. Such a process is called tautomerization, and the participants in this process are tautomers or tautomeric forms.

According to scientists, salen – the substance at the photo – is relatively simple and inexpensive to synthesize. Credit: UrFU / Damir Safin

“We’ve explored the potential interaction of various tautomers salen with SARS-CoV-2 proteins to identify the most preferred tautomeric form of the studied molecule in terms of the effectiveness in interaction with proteins.

“Of course, our research is only the first step towards understanding how salen can be used in the fight against Covid-19, much remains to be explored. However, the results we obtained inspire a certain optimism”, adds Damir Safin.

A study was carried out by scientists from the Innovation Center of Chemical and Pharmaceutical Technologies of Ural Federal University, Kurgan State University and Tyumen State University.

About this COVID-19 research news

Author: Anna Marinovich
Source: Ural Federal University
Contact: Anna Marinovich – Ural Federal University
Image: The image is credited to UrFU / Damir Safin

Original Research: Closed access.
“Salen: Insight into the Crystal Structure, Hirshfeld Surface Analysis, Optical Properties, DFT, and Molecular Docking Studies” by Damir Safin et al. Polycyclic Aromatic Compounds

See also


Abstract

Salen: Insight into the Crystal Structure, Hirshfeld Surface Analysis, Optical Properties, DFT, and Molecular Docking Studies

We report on a known Schiff base dye salen. The crystal structure of salen is in the enol–enol tautomer. Molecules are packed into a 3D supramolecular framework through C–H···π interactions.

The absorption spectrum of salen in CH2Cl2 exhibits three bands in the UV region, while the spectrum in MeOH contains an additional band at 403 nm and a shoulder at 280 nm, corresponding to the cis-keto tautomer. The emission spectrum of salen in MeOH exhibits a band at 435 and 457 nm upon irradiation at 280 and 400 nm, respectively, arising from the enol–cis-keto* and/or cis-keto–cis-keto* tautomers.

The solution of salen in CH2Cl2 showed dual emission with the bands at 349 and 462 nm upon irradiation at 290 nm with the low-energy emission band arising from the enol–cis-keto* and/or cis-keto–cis-keto* tautomers, while the high-energy band corresponds to the enol–enol* tautomer. The emission spectrum of salen in CH2Cl2 exhibits a single band at 464 nm upon irradiation at 380 nm, arising from the different conformers of the enol–cis-keto* and/or cis-keto–cis-keto* tautomers. The DFT calculations revealed that the enol–enol tautomer is the most favorable, followed by the enol–cis-keto tautomer.

The global chemical reactivity descriptors were estimated from the HOMO and LUMO. The DFT calculations were also applied to probe salen as a potential corrosion inhibitor for some important metals used in implants.

The enol–cis-keto and enol–trans-keto tautomers exhibit the best electron charge transfer from the molecule to the surface of all the studied metals, of which the most efficient electron charge transfer was established for Ni, Au, and Co. Molecular docking was applied to study interaction of tautomers of salen with a series of the SARS-CoV-2 proteins, of which the best binding affinity was found toward nsp14 (N7-MTase).

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Gay men are the “canary in the coal mine” of future pandemics, warns doc seeking HIV cure

Posed by models (Photo: Shutterstock)

The trial of a potential HIV cure is underway. The scientists involved hope for initial results by November. One of them also has stark warnings about the threat to humanity of future pandemics. He believes that, as seen with HIV and monkeypox, gay men could be the “canary in the coal mine.”

Dr. Marcus A. Conant is a consultant dermatologist whose career pre-dates the first cases of AIDS in the US. He’s now Chief Medical Officer for the biotech company, American Gene Technologies (AGT). It’s been working for the past few years on a groundbreaking HIV cure.

Rather than medication, AGT uses gene technology to boost the capacity of the body’s own immune cells to fight HIV.

A tiny number of individuals are genetically resistant to the effects of HIV. There are cases where people with HIV have undergone a bone marrow transplant and inherited the gene-resistant immune cells from such individuals. This has cured them of HIV.

However, a bone marrow transplant is a risky procedure. Doctors only consider it when someone is fighting a terminal, blood-related cancer like leukemia. It is not a practical, widespread treatment for HIV when medication for the disease already exists.

Instead, AGT wants to use gene technology to produce the same effect. Its process involves removing some white blood cells from an HIV-positive patient and then inserting a gene that modifies them. This enables the cells to stop HIV replication.

Using gene therapy as a potential HIV cure

Hundreds of thousands of the HIV-resistant CD4 T-cells are then infused back into the patient, where they can duplicate and—hopefully—fight HIV.

In 2020, the FDA gave approval for AGT to start a trial involving seven patients. Those patients have had their own genetically-modified T-cells (AGT103-T) infused back into them.

None experienced any negative side effects from the infusion, meaning the trial has now proceeded to its next stage. Each patient has had their antiretroviral treatment stopped. They are being closely monitored to see if their viral loads remain undetectable.

Related: New study says HIV has a “significant” impact on aging process

Dr. Conant is not able to give Queerty any advance insight into the trial’s results when we catch up with him via the phone. It’s been kept under wraps until later this year. However, he does say that he and his team are already planning a larger trial.

Dr. Marcus Conant is working to find a HIV cure (Photo: AGT)

“It’s what science has always done,” he explains. “You ask, ‘Well which part of it is working? Why do we think that’s working? And how do we make that work better?’

“When AZT came out in 1987, it only worked just minimally. We were able to demonstrate that it was barely prolonging the lives of patients.

“Now here we are 30 years later, with drugs that can suppress the virus essentially to levels so low that patients can have unprotected sex and they don’t transmit the virus. That’s an amazing advance. But it was achieved by asking, ‘What can we do to make it work better?’”

“So there will now be another study, probably in 30-50 patients. My staff and I are designing that study as we speak, to take what we learn from this and treat more patients. We will tweak it to make it even better.”

HIV cure eludes science for more than four decades

Gene therapy has been used to treat several conditions over the past 20 years. This includes severe combined immune deficiency syndrome (SCID) and the eye condition, retinitis pygmantosa.

However, this is the first time it’s been used as a potential treatment for HIV. If it works, it would be groundbreaking.

HIV (in green) on an immune cell (Photo: CDC/Public Domain)

HIV has proved stubbornly resistant to a cure. It’s something Conant is only too well aware of. He has been working in the field since the early 1980s. As a dermatologist, he saw some of the first cases of men with Kaposi’s Sarcoma (KS) – one of the rare cancers that became the hallmark of AIDS before treatment became available.

Conant was a junior professor at UC San Francisco in 1981. He still vividely remembers seeing his first KS case in April that that year. It was a couple of months before the CDC issued its first public warning of an illness affecting gay men.

Related: Makers of once-every-six-months HIV treatment file for FDA approval

HIV, monkeypox and the threat of more pandemics

Because of his experience with HIV, Conant said he felt a sense of déjà vu when he heard of this year’s monkeypox outbreak. Cases in the US have now exceeded 23,00 and the majority are gay men.

Conant says the world must be better prepared for such outbreaks.

“The first thing you see in any epidemic is denial: ‘It can’t happen to us.’

“The second thing you always see is: Someone to blame. And that’s exactly what we saw with HIV/AIDS. And that’s exactly what we’re seeing now with monkeypox: ‘Oh, those gay guys, if they weren’t so promiscuous then the disease would never have happened.’

No,” he affirms. “The disease was going to happen. It just happened in a special group first. Instead of people blaming the gay community, they should realize this is an opportunity to realize that we’re going to have more and more of these zoonotic diseases, which jump from animals to humans.

“The gay community may well be the first group in which we see this, or in whom we frequently first see this.

“Why is that? Because gay men have opportunities to travel far more frequently than their straight brothers who are raising children and staying at home and don’t have the luxury of being able to pick up any time they want to and go to a party in Spain.

“So all of that is very much like the canary in the coal mine. What’s happening in the gay community is a warning to society: ‘We’ve got a problem here.’

“In the last 40 years we’ve had HIV, you had Ebola, you had Zika, you had Covid, and now monkeypox. That’s five off the top, just in my lifetime, and this is going to continue because people are traveling more.”

Conant agrees with other scientists who say global warming will increase the likelihood of pandemics. Rising temperatures are causing viruses to spread out of their previous habitats.

International solutions to global outbreaks

Conant wants to see a far more international solution to outbreaks, rather than countries just doing their own thing. After all, viruses have no respect for borders.

He also thinks governments must take more steps to allow individuals to isolate themselves when necessary.

“They tell gay men who have the disease, ‘Well go home and isolate.’ In America, a gay man can’t go home and isolate,” he says.

“Sure, you can order in all your food, but if he doesn’t have an income, he can maybe order the food in for a week, and then he’s running out of money. We don’t have an infrastructure set up that makes ‘go home and isolate’ a practical solution.

“If we don’t come up with some way to handle these diseases, we are facing a potential disaster,” he continues. Both Covid and monkeypox have a relatively low mortality rate. He warns that if a disease came along that killed—say—40% of the people who acquired it, “we are going to see societies collapse.”

“We should have learned from AIDS,” says Conant. “Forty years ago, AIDS was the first real clear warning that ‘hey, we need better policies for handling problems like this,’ and we learned nothing. And here we are, after one disease after another, and we respond to each one as if it’s a one-off and it will never happen again.”

David Hudson is a contributing editor at Queerty. Follow him on Twitter at @davidhudson_uk



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Los Angeles County public health officials investigating person’s death possibly caused by monkeypox

LOS ANGELES (KABC) — Health officials on Thursday said they were investigating a death in Los Angeles County that was possibly caused by monkeypox.

The investigation was announced by Dr. Rita Singhal, chief medical officer of the county Department of Public Health.

“We are early in the investigation and do not have additional details available at this time,” Singhal said. “As soon as details become available, we will share them while maintaining confidentiality and privacy.”

The death is the second in the United States being investigated as possibly caused by monkeypox, according to Singhal.

She said the county will be working with the U.S. Centers for Disease Control and Prevention and the state as it investigates the circumstances of the person’s death.

The U.S. leads the world with monkeypox infections – as of Wednesday, 21,274 cases had been reported – with men accounting for about 98% of cases and men who said they had recent sexual contact with other men about 93% of cases.

Monkeypox, which can cause a rash, fever, body aches and chills, is spread through close skin-to-skin contact and prolonged exposure to respiratory droplets. The Centers for Disease Control and Prevention has recommended that men or transgender people who have had multiple male sex partners consider vaccination.

City News Service contributed to this report.

Copyright © 2022 KABC Television, LLC. All rights reserved.



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