Tag Archives: Cure

There’s now a cure for Dragon’s Dogma 2’s dreaded pawn pox Dragonsplague: mods – Rock Paper Shotgun

  1. There’s now a cure for Dragon’s Dogma 2’s dreaded pawn pox Dragonsplague: mods Rock Paper Shotgun
  2. Dragon’s Dogma 2 players are warning each other about potentially killer pawns with rotten food and flesh PC Gamer
  3. Dragon’s Dogma 2 Players Are Fighting Dragonsplague In New Ways Kotaku
  4. Dragon’s Dogma 2 players have quietly devised a way to warn others of the dreaded Dragonsplague – but it might not be enough Gamesradar
  5. Good news, Dragonsplague-fearing idiots, there’s now a Dragon’s Dogma 2 mod that slaps your pawn’s infection level right on their forehead VG247

Read original article here

The Truth About Ketamine: Depression Cure, Health Fad, or Placebo? – The Ringer

  1. The Truth About Ketamine: Depression Cure, Health Fad, or Placebo? The Ringer
  2. How ketamine therapy can be used to treat depression The Telegraph
  3. A Boise clinic uses the drug ketamine to treat depression. Is it legal? How does it work? Idaho Statesman
  4. NRx Pharmaceuticals Announces Signing of a Data and Technical Information Agreement with Columbia University Accessing Key Data Demonstrating Efficacy and Safety of Intravenous Ketamine for the Treatment of Suicidal Depression Yahoo Finance
  5. Efficacy and safety of ketamine-assisted electroconvulsive therapy in major depressive episode: a systematic review and network meta-analysis | Molecular Psychiatry Nature.com

Read original article here

Florida man, sons sentenced to years in prison after being convicted of selling bleach as fake COVID-19 cure – CBS News

  1. Florida man, sons sentenced to years in prison after being convicted of selling bleach as fake COVID-19 cure CBS News
  2. Family Sentenced for Selling Bleach as ‘Miracle’ Covid-19 Cure The New York Times
  3. Florida family sentenced to federal prison for selling ‘dangerous,’ fake COVID-19 cure: DOJ ABC News
  4. Using fake church, Florida clan sold bleach as ‘miracle’ cure. Dad, 3 sons going to prison Miami Herald
  5. Leaders of “Genesis II Church of Health and Healing,” who sold toxic bleach as fake “Miracle” cure for COVID-19 and other serious diseases, sentenced to more than 12 years in federal prison Department of Justice
  6. View Full Coverage on Google News

Read original article here

Family Sentenced for Selling Bleach as ‘Miracle’ Covid-19 Cure – The New York Times

  1. Family Sentenced for Selling Bleach as ‘Miracle’ Covid-19 Cure The New York Times
  2. Florida family sentenced to federal prison for selling ‘dangerous,’ fake COVID-19 cure: DOJ ABC News
  3. Using fake church, Florida clan sold bleach as ‘miracle’ cure. Dad, 3 sons going to prison Miami Herald
  4. Leaders of “Genesis II Church of Health and Healing,” who sold toxic bleach as fake “Miracle” cure for COVID-19 and other serious diseases, sentenced to more than 12 years in federal prison Department of Justice
  5. Florida family sentenced for selling bleach as fake COVID-19 cure through online church NBC 6 South Florida

Read original article here

Federal jury convicts 4 Florida men for selling bleach solution as ‘miracle’ cure for diseases – Miami Herald

  1. Federal jury convicts 4 Florida men for selling bleach solution as ‘miracle’ cure for diseases Miami Herald
  2. ‘Church of Bleach’ family found guilty of selling fake COVID-19 cure through online church ABC7
  3. 4 members of a Florida family are convicted of selling a fake COVID-19 cure through online church The Associated Press
  4. A Florida family that allegedly sold bleach as a COVID-19 cure is on trial in Miami NBC 6 South Florida
  5. Church of Bleach: Florida family found guilty of selling fake COVID-19 cure through online church KABC-TV
  6. View Full Coverage on Google News

Read original article here

Exclusive: Mark Zuckerberg And Priscilla Chan On Their New ‘Biohub’ In Chicago And How They Plan To Spend Billions To Help Others Cure Or Manage Disease – Forbes

  1. Exclusive: Mark Zuckerberg And Priscilla Chan On Their New ‘Biohub’ In Chicago And How They Plan To Spend Billions To Help Others Cure Or Manage Disease Forbes
  2. Chan Zuckerberg Biohub Chicago Launches – CZI News Chan Zuckerberg Initiative
  3. Mark Zuckerberg funding Chicago university biotech hub Crain’s Chicago Business
  4. Group founded by Mark Zuckerberg to spend $250 million on new Chicago biotech hub, with researchers from Northwestern, UChicago and UIUC Chicago Tribune
  5. Facebook founder Mark Zuckerberg and wife to invest $250 million in new Chicago research lab Chicago Sun-Times
  6. View Full Coverage on Google News

Read original article here

I’ve snored for years… can surgery cure me? DR MARTIN SCURR answers your health questions

I snore — loudly, apparently — but it’s not sleep apnoea. Twenty years ago, I tried septoplasty surgery and that helped, but I crashed my bike and ruined my nose, so the snoring came back.

I was offered another operation but was told it was painful and might not work. Has anything changed in the snoring department since then? I’m 58, 5ft 8in, 11st and really quite fit — I cycle 15 miles a day.

Grog Fookes, Woking, Surrey.

Snoring is often caused by obstructive sleep apnoea, where the tissues in the throat temporarily collapse during sleep.

One of the main risk factors is weight gain, but at 11st that does not apply to you, and indeed sleep apnoea has been ruled out (which is good news, as it’s linked to a raised risk of heart attack or stroke).

Smoking and drinking too much alcohol are also known to increase the likelihood of snoring — smoking can cause congestion in nasal passages and alcohol relaxes muscles in the throat — so cutting back on both can help.

Snoring is often caused by obstructive sleep apnoea, where the tissues in the throat temporarily collapse during sleep

Sleeping on your side may also be beneficial, as it can reduce the tendency for the tissue in the back of the roof of the mouth, the soft palate, to collapse and cause intermittent obstruction. The air you breathe out makes the tissue vibrate, causing the snoring sound.

The operation you had all those years ago involves straightening the septum, the bony cartilage that separates the nostrils. A deviated (or crooked) septum is a common cause of snoring. While this operation is no longer so much in favour (the evidence that improving the airways in both nostrils can help snoring is lacking), the fact that this originally worked for you suggests the internal structure of your nose may be a factor.

I suspect the second operation you were offered was uvulopalatopharyngoplasty (UPPP) surgery, where tissue at the back of the throat, often including part of the soft palate, is cut away.

While research shows this can reduce the intensity of snoring, long-term studies do not bear this out — the results do not seem to be permanent.

Bearing in mind that snoring is common, affecting more than 40 per cent of men and nearly 30 per cent of women between the ages of 30 and 60, is it essential to pursue a resolution?

The potential complications and post-operative pain, which is legendary, also rule against having this surgery, so my feeling is you were right to avoid it.

There are newer procedures, such as radiofrequency ablation, which uses heat rather than a scalpel to reduce the volume of the soft palate.

It has been shown to be a safe and effective way to reduce snoring (with less post-operative pain than UPPP), though it’s not clear how long the benefits last.

Palatal implants involve implanting polyester fibres into the soft palate to stiffen it. While this also reduces snoring, the long-term outcomes are again less certain.

As you can see, there’s nothing magical or new that can readily resolve your symptom.

Bearing in mind that snoring is common, affecting more than 40 per cent of men and nearly 30 per cent of women between the ages of 30 and 60, is it essential to pursue a resolution?

As long as sleep apnoea has been ruled out, you may well be advised to accept the situation.

My friend bashed his head on the bath recently and has since had blurred vision, is wobbly on his feet and has been vomiting. He refuses to go to hospital — what can I do?

Eloise Few, Notting Hill, London.

Your friend may need a CT scan of his head. The symptoms you describe — along with fatigue, dizziness, loss of balance, mood changes and slurred speech — may indicate an underlying brain injury.

Even a minor blow to the head can cause problems such as concussion, an intracranial haematoma (when a blood vessel ruptures and the blood builds up in the tissues) and a cerebral contusion (a localised bruising within the brain).

Much depends upon his age — the brain tissue of the elderly is more susceptible to damage from even minor impact.

Your friend may need a CT scan of his head. The symptoms you describe — along with fatigue, dizziness, loss of balance, mood changes and slurred speech — may indicate an underlying brain injury

If symptoms persist, particularly if his mood changes or he continues to be unsteady on his feet, then try to persuade him to seek a medical opinion.

I’m nearly 80, very fit and work in the laundry room of a nursing home. I am 5ft 2in and have always been very slim, but I’m currently around 7st and worry I might be too thin, as everyone seems to think I’m ill.

Madeleine Kelly, East Sussex.

Your body mass index, a figure that combines weight and height, is at the lower end of the healthy range — so I see no cause for concern.

But there are things you can do if you’re worried.

You say in your longer letter that you’ve always had a small appetite and been active.

Add to this sarcopenia — the inevitable and gradual loss of muscle over time (after the age of 30, you lose between 3 and 5 per cent of muscle every decade) which will inevitably cause weight loss, as muscle is three times as heavy as fat.

You can minimise this muscle loss by eating more protein — meat, fish and eggs — and taking regular exercise. Omega-3 fatty acids also stimulate muscle growth; oily fish such as tinned mackerel or sardines are a good source.

In terms of exercise, try lifting weights of around 2kg to 3kg for 30 minutes three times a week.

Write to Dr Scurr

Write to Dr Scurr at Good Health, Daily Mail, 9 Derry Street, London W8 5HY or email: drmartin@dailymail.co.uk — include contact details. Dr Scurr cannot enter into personal correspondence. Replies should be taken in a general context. Consult your own GP with any health worries 

In my view… Give tax relief on fees for seeing private GP 

The Prime Minister has been widely criticised for initially declining to say whether he has a private GP.

He finally told the House of Commons that he does, in fact, have an NHS GP — three days after ducking the question during an interview. I really don’t understand his reluctance to reveal this.

We’re all entitled to pay for medical care outside of the NHS, and many do so — cosmetic surgery being a prime example.

Margaret Thatcher had no hesitation in using a private GP, as did the Pope when he visited the UK in 1982 (that private doctor was me!). In my private practice I have also seen Labour MPs and peers who have no problem stepping outside of the NHS, despite their proclaimed ideology.

When I was a house surgeon at Westminster Hospital in 1972, Marcia Falkender, secretary to Labour leader Harold Wilson, was treated on our unit in a private room.

Harold Wilson’s government later set out to abolish pay-beds in NHS hospitals.

Whatever his own position, Rishi Sunak should allow tax relief on the cost of seeing a GP privately to reduce pressure on the NHS.

Read original article here

Scientists find potential cure for COVID-related loss of smell

If a lost ability to smell after a COVID-19 infection has sapped some of the color from your world, relief might be on the way. (Stephanie Amador, Associated Press)

Estimated read time: 4-5 minutes

TORONTO — A team of researchers in California struck upon a possible cure for long-term COVID-19-related smell loss that uses a blood product from patients’ own bodies.

In a randomized, controlled trial of 26 patients who had lost their sense of smell following a COVID-19 infection, half received nasal injections of platelet-rich plasma derived from their own blood, while the rest received a placebo.

The study’s authors, researchers from the University of California and Stanford University, found that those who received the treatment were 12.5 times more likely to improve than patients who received placebo injections. The results were published Dec. 12 in the International Forum of Allergy and Rhinology.

Dr. Zara Patel, one of the authors and a professor of otolaryngology at Stanford Medicine, has studied loss of smell as a symptom of viral infections for years.

“Many viruses can cause smell loss, so it wasn’t surprising to us as rhinologists when we found out that COVID-19 causes loss of smell and taste,” she said in a media release published on Monday. “It was almost expected.”

Patel knew the condition could last for months, that it was related to nerve damage and that few effective treatments were available. She also knew platelet-rich plasma has been promoted as a treatment for other nerve-related ailments such as carpal tunnel syndrome.

Platelet-rich plasma is a concentrated form of plasma — the liquid portion of blood — minus blood cells and other blood components. It’s rich in platelets and growth factors, which are compounds known to help regenerate tissue. Platelet-rich plasma injections have been tested as a treatment for mild arthritis, wrinkles and hair loss.

According to Patel’s research, COVID-19-related smell loss is a neurological problem in which the virus prevents nerves deep in the nasal cavity from regenerating correctly, even after an infection has subsided. These nerves connect to the brain and normally regenerate every three to four months.

“It’s a nerve damage and nerve regeneration issue that we’re dealing with,” Patel said.

Patel had already completed a small pilot study demonstrating the safety of platelet-rich plasma injections in the nasal cavity when the pandemic hit, so it was natural to pivot her plans for a larger trial to focus specifically on COVID-19-related smell loss.

According to her research, SARS-CoV-2 doesn’t target nerve cells directly. Instead, it attacks supporting cells known as sustentacular cells, which have the ACE-2 receptor the virus uses to infect cells. These cells play a role in correct nerve regeneration, so persistent inflammation and damage to these cells may lead to long-term loss of function.

Patel’s hope was that by injecting platelet-rich plasma into the site of her subjects’ nasal nerve damage, she could promote the regeneration of those nerves required for smell and taste.

Patients who had suffered from a persistent loss of smell lasting between six and 12 months were given injections — either of platelet-rich plasma or sterile saline — every two weeks for six weeks. They were then tested on their ability to detect and identify a range of odors for three months afterward.

Three months after their first injection, 57% of the platelet-rich plasma group had shown significant improvement, compared with just 8.3% in the placebo group. Everyone recruited for the study had previously tried other treatments – such as olfactory training and steroid rinse – with no success.

Following the success of the experiment, Patel now offers nasal platelet-rich plasma injections to patients outside of the trial.

A survey Patel conducted with colleagues from California and the United Kingdom in 2022 revealed that about 15% of people who experienced smell loss from COVID-19 — or nine million Americans — continued to have problems for at least six months.

“People tell me all the time that they never realized how important their sense of smell and taste was to them and their quality of life until they lost it,” she said. “People say, ‘My life has gone gray.'”

Patel hopes therapies like platelet-rich plasma injection will help more of these people regain their sense of smell.

“Our olfactory systems can be resilient,” she said. “But the sooner you perform some sort of definitive intervention, probably the better chance you have of improvement.”

Related stories

Most recent Coronavirus stories

Megan DeLaire, CTVNews.ca

More stories you may be interested in

Read original article here

How COVID Vaccines Could Actually Help Scientists Find a Cure to Cancer

The novel coronavirus could help us cure cancer. Well, certain cancers.

The COVID pandemic gave the pharmaceutical industry the push it needed to finally finish developing messenger-RNA technology so that companies such as Moderna and Pfizer could use the tech for its COVID vaccines.

Now the pharmaceutical industry is using the same mRNA platforms for cancer vaccines. Dozens of these new vaccines are in development—and experts say there’s a chance they’ll drive the biggest decrease in cancer mortality in decades.

It’s worth noting a key difference between mRNA shots for COVID versus mRNA shots for cancer. MRNA vaccines prevent COVID. They won’t prevent cancer. Instead, they’ll treat cancer after you’ve caught it. In that sense, “vaccine”—even though it’s the accepted term—is something of a misnomer when it comes to mRNA applications for cancer. “Therapy” might be a better term.

In any event, mRNA vaccines for cancer have been in the works for a couple of years now, but the first tangible sign of real progress came just last week. On Dec. 13, Massachusetts-based Moderna and partner Merck—the New Jersey pharma giant—announced the initial results of the first ever randomized human trial for an mRNA cancer vaccine.

The two companies enrolled 157 people with late-stage melanoma for the trial. Volunteers received either the antibody therapy Keytruda, or Keytruda combined with a new vaccine called mRNA-4157. Adding mRNA-4157 reduced the risk of recurrence or death by 44 percent, the companies reported.

The key to mRNA-4157, and any other mRNA cancer vaccine, is that it can be tailored for an individual patient. As its name implies, “messenger RNA” is just a medium that communicates a message. The message is a scrap of genetic material—RNA—that tells a person’s immune system to produce a particular, disease-fighting protein.

Developers can encode mRNA to produce a wide array of proteins. For, say, preventing COVID—or reducing different cancerous tumors. “The flexibility is extraordinarily attractive,” Elias Sayour, a University of Florida neurosurgeon whose RNA Engineering Laboratory is working on cancer vaccines, told The Daily Beast.

But the flexibility that makes an mRNA vaccine so attractive is also a problem. How do you know exactly what RNA to add to a particular patient’s vaccine? “Not all cancers are the same,” Sayour explained. “To overcome this, prediction algorithms are used to identify unique information in an individual’s cancer that will be recognized by their immune system.”

MRNA was in development for nearly 50 years before COVID finally compelled governments to pump money into the effort, helping the industry finally finish the first mRNA vaccines two years ago. The basic platform for an mRNA cancer jab is actually pretty old. It’s the algorithms that are new.

“The manufacturing process starts with the identification of genetic mutations in a patient’s tumor cells that could give rise to neoantigens,” the U.S. National Cancer Institute explained. Neoantigens are proteins that form on cancer cells. “Computer algorithms then predict which neoantigens are most likely to bind to receptors on T-cells and stimulate an immune response,” the institute added.

In theory, an mRNA-maker could produce a personalized cancer vaccine in as little as four weeks, Sayour said. In practice, we need a lot more mutation-detecting algorithms and a lot more testing before mRNA vaccines are ready for routine use on cancers.

Sayour stressed that mRNA will probably work better for some cancers than for others. Not all cancers are “immunogenic,” meaning they trigger an immune response. Without an immune response, we might not know which protein to encode in an mRNA jab. “MRNA vaccines are likely to work in cancers like melanoma that are considered immunogenic,” Sayour explained. Temper your expectations for other cancers.

There are other possible limitations on mRNA as a cure for cancer. Henry Wang, a chemical engineering professor who studies vaccine production at the University of Michigan, told The Daily Beast he’s worried about production.

You can’t churn out mRNA cancer shots the same way you churn out mRNA shots for COVID. How do you scale and manage production of a drug that requires such careful and detailed individualization? “It creates an entirely different set of [quality-control] and manufacturing issues,” Wang said.

There’s also the issue of cost. Because they’re essentially boutique products, each vaccine would be designed for one or a few people and manufactured in small quantities. That means mRNA cancer jabs may end up being really expensive. It’s possible mRNA will work great against some or many cancers, but be too pricey for most people. “Someone has to address the issue of cost versus benefit,” Wang said.

Sayour, for one, said he’s optimistic. Even taking into account the problems of customization and production, mRNA seems to be our best near-term pharmaceutical tool for reducing cancer deaths. “It seems to have the best balance of commercialization and personalization.”

If pharmaceutical developers can write a host of algorithms, complete large-scale trials, figure out the production processes and thread the cost-benefit needle, cancer vaccines might be viable—and save a lot of lives.

Even if they can’t, and mRNA jabs for cancer fall flat, the basic tech could still have a bright future. Moderna is already working on mRNA jabs for around two dozen diseases, including herpes and Zika. German firm BioNTech SE is even working up mRNA for multiple sclerosis.

MRNA got its start preventing COVID. Treating cancer might be next. It’s a safe bet that neither disease will be the last to square off with this particular tech.

Read original article here

New way of using DNA to kill cancer cells could pave the way for a cure, scientists say

New way of using DNA to kill cancer cells could pave the way for a cure, scientists say

  • University of Tokyo scientists may have paved a way to use DNA to cure cancer
  • Study author Professor Akimitsu Okamoto says their research is ‘good news’
  • It uses a hair clip shaped, cancer-killing DNA, which is injected into cancer cells 

A new way of using DNA to kill cancer cells which could pave the way for a cure for the disease has been created by scientists.

Professor Akimitsu Okamoto from the University of Tokyo and an author of the study, has said the research is ‘good news’ and will open up new options for cancer treatments.

The method targets human cervical cancer and breast cancer-derived cells, as well as malignant melanoma cells in mice.

It uses a pair of hair clip shaped, cancer-killing DNA which are injected into cancer cells.

Professor Akimitsu Okamoto (pictured) from the University of Tokyo, has a new way of using DNA to kill cancer cells which could pave the way for a cure said the research is ‘good news’ and will open up new options for cancer treatments

The method created by scientists at the University of Tokyo (pictured) targets human cervical cancer and breast cancer-derived cells, as well as malignant melanoma cells in mice

When they were injected into them, they connected to molecules called microRNA which are overproduced in certain cancers.

Once connected to the microRNA they unravelled and formed longer chains of DNA which created an immune response.

The immune system recognised the overproduced microRNA cells as dangerous, which activated a natural immune response which killed the cancer cells.

The Japanese research team say their method is different from existing ones and could herald in a new era of breakthrough cancer drugs.

Prof Okamoto said: ‘The results of this study are good news for doctors, drug discovery researchers and cancer patients, as we believe it will give them new options for drug development and medication policies.

‘Next, we will aim for drug discovery based on the results of this research, and examine in detail the drug efficacy, toxicity and potential administration methods.’

He added: ‘We thought that if we can create new drugs that work by a different mechanism of action from that of conventional drugs, they may be effective against cancers that have been untreatable up to now’ 

The new cancer research uses a pair of hair clip shaped, cancer-killing DNA which are injected into cancer cells

 

Cancer is sadly a familiar health concern and existing ways of treating it have their limitations, however drugs based on DNA and RNA are expected to help scientists eventually beat it.

This is because DNA and RNA are vital information-carrying molecules that can control the biological function of cells.

They are expected to transform the future of medicine and help cure other hard to treat illnesses caused by viruses and genetic diseases.

Using DNA and RNA to treat cancers has been difficult because it is hard to get them to differentiate between cancerous and healthy cells.

This means a patient’s immune system can be adversely effected if healthy cells are attacked.

However, this was the first time scientists were able to develop a hairpin-shaped DNA strand that can activate a natural immune response to target and kill specific cancerous cells.

The findings were published in the Journal of the American Chemical Society.

Read original article here