When people are infected with a virus or other pathogen, their bodies unleash proteins called antibodies that detect foreign substances and keep them from invading cells. In some cases, however, people produce autoantibodies that can attack the body’s own organs and tissues over time. The findings, which are based on 177 people with confirmed evidence of a previous COVID-19 infection, reveal that people with a prior infection of SARS-CoV-2, the virus that causes COVID-19, have a wide variety of autoantibodies up to six months after they have fully recovered.
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“These findings help to explain what makes COVID-19 an especially unique disease,” said Justyna Fert-Bober PhD, co-senior author of the study. “These patterns of immune dysregulation could be underlying the different types of persistent symptoms we see in people who go on to develop the condition now referred to as long COVID-19.”
Israeli soldier line up in a queue at the entrance of a COVID-19 rapid antigen Magen David Adom testing center in Jerusalem on January 03, 2022. (credit: OLIVIER FITOUSSI/FLASH90)
The researchers noted that they intend to expand the study to look for the types of autoantibodies that may be persistent in people with long-haul COVID-19 symptoms.