- Bitcoin Price Prediction as $10 Billion Trading Volume Comes In – Where is BTC Heading Now? Cryptonews
- Bitcoin traders in ‘disbullief’ as analyst predicts $30K BTC retest Cointelegraph
- Trader Who Accurately Predicted 2023 Crypto Rally Unveils Full-Bull Scenario for Bitcoin – But There’s … The Daily Hodl
- Is Bitcoin’s (BTC) Rally to $30,000 the Start of a New Crypto Boom? Bloomberg
- Bitcoin has crossed $30,000 again but the crypto industry is a shadow of what it was: ‘I don’t think there’s the mania’ Fortune
- View Full Coverage on Google News
Tag Archives: volume
Bob Iger: Disney Will Reduce Costs on Films, TV Shows to Focus on Quality, Not Volume – Hollywood Reporter
- Bob Iger: Disney Will Reduce Costs on Films, TV Shows to Focus on Quality, Not Volume Hollywood Reporter
- Bob Iger Questions Marvel Sequels, Need to Bring Back Characters: ‘You’re Going to See a Lot of Newness’ Yahoo Entertainment
- Bob Iger Says Disney Theme Parks Were Priced Too High In “Zeal To Grow Profit” – It’s “A Brand That Needs To Be Accessible” Deadline
- Bob Iger Is ‘Bullish’ on Disney+ but ‘We Were Off’ on Pricing Strategy and Needed to Rationalize Costs Variety
- Disney boss Bob Iger vows to spend LESS on making new movies and TV to rein in costs Daily Mail
- View Full Coverage on Google News
Volume 611 Issue 7937, 24 November 2022
Pump, rest, leak, repeat
The cover illustration shows vacuolar-type adenosine triphosphatases (V-ATPases, large blue structures) on a synaptic vesicle from a nerve cell in the mammalian brain. V-ATPases pump protons across cellular membranes, and in neurons this process is essential for loading neurotransmitters into synaptic vesicles. In this week’s issue, Dimitrios Stamou and his colleagues shed light on V-ATPase dynamics in single native synaptic vesicles. By imaging proton-pumping at the single-molecule level, the researchers were able to see that V-ATPases do not pump continuously but instead switch between three distinct modes: proton-pumping, inactive and proton-leaking. The team suggests that this could indicate a broader biological role for ultraslow mode-switching in protein regulation.
Cover image: C. Kutzner, H. Grubmüller and R. Jahn/Max Planck Institute for Multidisciplinary Sciences; Jens Carstensen/University of Copenhagen
Volume 609 Issue 7926, 8 September 2022
Dinosaur distribution
The cover shows an artist’s impression of Mbiresaurus raathi, a newly discovered species of herbivorous dinosaur found in Zimbabwe and dating to around 230 million years ago. The remains of the sauropodomorph were part of a collection of fossils from the Late Triassic that contains Africa’s oldest known dinosaurs. Discovered by Christopher Griffin and colleagues along with palaeontologists at the Natural History Museum of Zimbabwe, these fossils are discussed in this week’s issue. The researchers note that the remains correlate with those of similar vertebrates found in the same latitude band in South America and India, suggesting that the distribution of the dinosaurs correlated with climatic barriers. The team notes that this agrees with the idea of arid and humid climate belts running east–west across the supercontinent Pangaea, indicating that the range of these early dinosaurs was constrained to southern Pangaea until those climatic barriers relaxed.
Cover image: Andrey Atuchin
Steroids Linked to Structural and Volume Changes in Brain White and Grey Matter
Summary: Steroids prescribed for a range of inflammatory conditions alter the structure and volume of grey and white matter in the brain. The findings shed light on why people who use medical steroids may experience psychological problems, including anxiety, mania, and depression.
Source: BMJ
The use of prescribed steroids, including in inhalers, is linked to changes in the structure and volume of white and grey matter in the brain, suggests the findings of the largest study of its kind, published in the open access journal BMJ Open.
The associations found might help to explain the neuropsychiatric effects, such as anxiety, depression, mania, and delirium frequently seen after long term use, say the researchers.
Their immunosuppressive properties mean that glucocorticoids, a class of synthetic steroids, are among some of the most frequently prescribed drugs. They are used to treat a wide variety of medical conditions.
The estimated annual population prevalence in high income countries of systemic (infusions and tablets) medical steroid use is thought to range between 0.5% and 3%.
While very effective, both systemic and inhaled steroids are associated with many potentially serious metabolic, cardiovascular, and musculoskeletal side effects, as well as neuropsychiatric effects.
Previously published research suggests that long term medical steroid use is associated with structural abnormalities and shrinkage of certain areas of the brain. But most of these studies have involved only small numbers of people with specific conditions.
And it’s still not clear if these associations might also be observed in a broader sample of medical steroid users, including those using inhaled steroids for respiratory conditions, such as asthma.
In a bid to find out, the researchers drew on data from the UK Biobank, comprising half a million 40–69 year olds from the general population, to see if there were any detectable differences in brain volume and structure between users and non-users of systemic and inhaled steroids.
The researchers also wanted to know if steroid use might be associated with differences in processing speed and emotional responses.
The MRI brain scans of 222 people using systemic steroids and 557 using inhaled steroids were compared with those of 24,106 non-users.
None of the study participants had previously been diagnosed with neurological, psychiatric or hormonal (endocrinological) disorders or was taking mood altering drugs, such as antidepressants.
Participants filled in a questionnaire to assess certain aspects of mood over the previous fortnight.
Comparison of the MRI scan results showed that both systemic and inhaled steroid use was associated with less intact white matter structure than was seen on the scans of those not on these drugs. White matter has a role in neuronal connectivity and signalling in the brain.
The effects were greater in systemic users than in users of inhaled steroids. And further detailed analysis suggested that the effects might be even larger among long term users.
Systemic use was associated with a larger caudate compared with no use, while use of inhaled steroids was associated with a smaller amygdala. Both the caudate and amygdala are grey matter structures in the brain involved in cognitive and emotional processing.
Systemic steroid users also performed worse on a test designed to measure processing speed than non-users, and they reported significantly more depressive symptoms, apathy, restlessness and fatigue/lethargy than non-users. Inhaled steroid users reported only more tiredness/lethargy, and to a lesser degree than systemic steroid users.
“Although a causal relation between glucocorticoid use and changes in the brain is likely based on the present and previous studies, the cross-sectional nature of this study does not allow for formal conclusions on causality,” caution the researchers.
They also point to certain limitations. Only a few indicators of mood change were assessed, and only for the preceding 2 weeks; and the reported changes might have been related to the condition for which steroids were prescribed rather than to steroid use itself.
Nor were the researchers able to differentiate between steroid tablets and infusions for systemic users, all of which may have influenced the findings.
But they write:“While it remains unclear whether the observed effect sizes have clinical consequences for the population of glucocorticoid users as a whole, these findings are remarkable given the common neuropsychiatric side effects of synthetic glucocorticoids.”
And they conclude: “This study shows that both systemic and inhaled glucocorticoids are associated with an apparently widespread reduction in white matter integrity, which may in part underlie the neuropsychiatric side effects observed in patients using glucocorticoids.”
Given how widely used these drugs, both doctors and patients need to know about the possible effects on the brain, say the researchers, who now call for research into alternative treatment options.
About this neuropharmacology and neuroscience research news
Author: Caroline White
Source: BMJ
Contact: Caroline White – BMJ
Image: The image is in the public domain
Original Research: Open access.
“Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank” by Merel van der Meulen et al. BMJ Open
Abstract
Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank
Objective
See also
To test the hypothesis that systemic and inhaled glucocorticoid use is associated with changes in grey matter volume (GMV) and white matter microstructure.
Design
Cross-sectional study.
Setting
UK Biobank, a prospective population-based cohort study of adults recruited in the UK between 2006 and 2010.
Participants
After exclusion based on neurological, psychiatric or endocrinological history, and use of psychotropic medication, 222 systemic glucocorticoid users, 557 inhaled glucocorticoid users and 24 106 controls with available T1 and diffusion MRI data were included.
Main outcome measures
Primary outcomes were differences in 22 volumetric and 14 diffusion imaging parameters between glucocorticoid users and controls, determined using linear regression analyses adjusted for potential confounders. Secondary outcomes included cognitive functioning (six tests) and emotional symptoms (four questions).
Results
Both systemic and inhaled glucocorticoid use were associated with reduced white matter integrity (lower fractional anisotropy (FA) and higher mean diffusivity (MD)) compared with controls, with larger effect sizes in systemic users (FA: adjusted mean difference (AMD)=−3.7e-3, 95% CI=−6.4e-3 to 1.0e-3; MD: AMD=7.2e-6, 95% CI=3.2e-6 to 1.1e-5) than inhaled users (FA: AMD=−2.3e-3, 95% CI=−4.0e-3 to −5.7e-4; MD: AMD=2.7e-6, 95% CI=1.7e-7 to 5.2e-6). Systemic use was also associated with larger caudate GMV (AMD=178.7 mm3, 95% CI=82.2 to 275.0), while inhaled users had smaller amygdala GMV (AMD=−23.9 mm3, 95% CI=−41.5 to −6.2) than controls. As for secondary outcomes, systemic users performed worse on the symbol digit substitution task (AMD=−0.17 SD, 95% CI=−0.34 to −0.01), and reported more depressive symptoms (OR=1.76, 95% CI=1.25 to 2.43), disinterest (OR=1.84, 95% CI=1.29 to 2.56), tenseness/restlessness (OR=1.78, 95% CI=1.29 to 2.41), and tiredness/lethargy (OR=1.90, 95% CI=1.45 to 2.50) compared with controls. Inhaled users only reported more tiredness/lethargy (OR=1.35, 95% CI=1.14 to 1.60).
Conclusions
Both systemic and inhaled glucocorticoid use are associated with decreased white matter integrity and limited changes in GMV. This association may contribute to the neuropsychiatric side effects of glucocorticoid medication, especially with chronic use.
Volume 607 Issue 7919, 21 July 2022
Diversity hotspots
The cover shows an artistic impression of marine life in Indonesia’s coral reefs. The question of whether there are limits to biodiversity in the seas is typically addressed by examining the fossil record. In this week’s issue, Pedro Cermeño and his colleagues present a model that combines the fossil record with plate tectonics and Earth’s environmental conditions to offer insight into regional diversification of marine invertebrates. The researchers used the model to examine how biodiversity recovered after mass extinctions during the Phanerozoic eon, covering some 500 million years of Earth’s history. They found that throughout the Phanerozoic, less than 2% of area of the globe covered by water showed signs of diversity levels reaching saturation. The team also note that as Pangaea broke up into continents, the stability of Earth’s environmental conditions allowed the development of diversity hotspots that helped to drive an increase in biodiversity in the late Mesozoic and Cenozoic eras.
Cover image: Confluence (Our Changing Seas V) (2018) by Courtney Mattison. Glazed stoneware and porcelain. 846 x 570 x 50 cm. Permanent Collection of the US Embassy, Jakarta, Indonesia. Courtesy of Art in Embassies, US Department of State. Photo by Amanda Brooks.
Who dies in Stranger Things season 4, Volume 2?
Who dies in Stranger Things season 4, Volume 2? That’s a fair question. Even if you’ve watched both episodes on repeat since they arrived on Netflix, there’s some ambiguity around the fates of certain characters. And, seeing as this is certainly the darkest installment in the series yet, you may just want a recap of the body count. Or, if you don’t want to watch the (excellent) new series and just want a cheat-sheet to who doesn’t make it out of the battle of Hawkins alive (and shame on you) then this is the article for you.
If you’re in floods of tears after watching, you had been warned. This season was always going to be messy – the Duffer brothers, the show’s creators, were previously asked whether we could expect a “body count”. Their dominions response? “For sure, for sure.” And yes, they delivered. But saying any more would be a spoiler. Don’t read any further if you don’t want to know who dies in Stranger Things season 4, Volume 2. There are major spoilers ahead. You have been warned!
Who dies in Strangers Things season 4, Volume 2? *spoilers ahead*
Does Max die in Stranger Things?
Max almost succumbed to Vecna’s dark dimension in the fourth episode of the season. Fortunately, her friends (and Kate Bush’s ‘Running Up That Hill’) helped her consciousness fight the veiny villain and find its way back to her body in the real world. In Volume 2, Max persuades the gang to use her as bait for Vecna’s spirit, while the others fry his physical form in the Upside Down – but it doesn’t take long for things to go sideways.
First, Vecna infiltrates the happy memory Max is using to keep him at arm’s length – her time at the Hawkins’ Middle School Snow Ball – and then, during his attack on Lucas at the Creel House, Jason crushes her cassette player. Without music to snap her out of the Mind Layer, Vecna manages to overpower Max, and she starts levitating back in Hawkins.
As her limbs bend and break, blood starts seeping from her whited-out eyes, and it looks like she’s a goner, but Eleven intervenes in the nick of time and blasts Vecna’s consciousness away from her bestie. Back in the real world, Lucas orders Erica to call for an ambulance, as he cradles a badly injured Max, who says she can’t see or feel anything. A few minutes later, Max dies – her heart stops for one whole minute.
However, Eleven decides she’s seen enough death and… kind of… resurrects Max using her powers. Only not completely, because when we see Max next, she’s in a coma in the hospital. Eleven enters her mind and there’s no one there, only darkness. Let’s pray that, by the time Stranger Things season 5 rolls around, Max is conscious again.
Eddie Munson
This one hurts. Eddie Munson may have only joined Stranger Things at the beginning of season 4, but he quickly became one of the best characters on the show. The Dungeons & Dragons loving, heavy-metal stan wormed his way into our hearts from his first introduction in the school canteen. He didn’t have a very easy time of it, though, as he got swept up in the Satanic Panic of ’80s Hawkins after he was the last person to be seen with Chrissy. Witnessing her brutal death, he went into hiding as the cops came after him. Dustin, Steve, and the Hawkins gang saved him and brought him into their plans to take down Vecna.
In the final battle, he and Dustin are given the job to lure the Demobats away from Steve, Nancy, and Robin so they have time to destroy Vecna’s body in the Upside Down. They’re warned not to be heroes – but unfortunately, it seems Eddie is not listening. At first, everything seems to be going well but then the bats start getting into the trailer through the vents. Dustin and Eddie decide to abandon ship. But at the last moment, Eddie changes his mind, leaving Dustin back in Hawkins to buy some more time.
It’s not long before the bats converge on him, leaving him with some very serious injuries. By the time Dustin gets back through the gate, Eddie is dying. As he lies in his arms, Eddie tells Dustin: “I didn’t run away this time, right?” as he makes him promise to look after the others. His final words are all about how he might finally graduate this year, on his third and final attempt. “I think it’s my year Henderson,” he tells him, “I think it’s finally my year.” ’86, baby. Excuse me, I think I might have something in my eye… You can read our in memoriam for Eddie Munson through that link.
Dr. Martin Brenner
It was a given that an episode titled ‘Papa’ would feature Brenner in a big way – and the eighth episode certainly did not disappoint. After her confrontation with Henry Creel (Jamie Campbell Bower) in his pre-Vecna phase, Dr. Martin Brenner (Matthew Modine) and Dr. Sam Owens (Paul Reiser) reveal to Eleven (Millie Bobby Brown) the truth about Vecna/Henry/One.
After telling the youngster that Henry is now killing kids in Hawkins, Eleven vows to travel back to Indiana to help her pals who have been caught up in the storm, but Brenner insists Eleven isn’t yet powerful enough to face the big bad. Owens reminds Brenner that they agreed their facility wouldn’t be a prison and that Eleven should be allowed to make her own choices. Control freak Brenner doesn’t listen, though, leading him to secure Owens and sedate Eleven.
Later, The Nina Project’s base is ambushed by Lt. Colonel Jack Sullivan, and in his attempt to get Eleven to safety, Brenner is fatally shot down by Sullivan’s men. As he bleeds out, he uses a remote to unlock the shock collar he had placed around Eleven’s neck, and he tells her that he’s always regarded her as his family. Murky ’til the very end.
Jason Carver
Jason Carver has been causing all kinds of issues throughout Stranger Things season 4. This only intensified in the finale when he tried to get Lucas to wake Max up from her “trance”. Not only did he destroy her Kate Bush tape, he almost choked Lucas to death while fighting with him. Therefore, you’ll forgive us if we’re not too sad to see the Hawkins High jock die.
His death came in a blink-and-you’ll-miss-it moment. After Lucas gets the upper hand beating him up, Jason is lying on the floor of Henry Creel’s house. It turns out to be the worst spot he could be in as Vecna’s plan succeeds and the gates to the Upside Down open across town. Jason is caught between two halves as his body is torn in half and disintegrates. Yikes. It’s a pretty grisly end for the basketball player. But given how he almost succeeded in ruining the whole plan to destroy Vecna, it seems he might have had it coming.
Is Vecna still alive?
Unfortunately for Eleven, Max, and the others, Vecna survived. Despite the villain being flambéd in the Upside Down by Steve, Robin, and Nancy, Will confirms that he can still sense Vecna in Hawkins. Indeed, when Steve and co. left the house where they fried Vecna, the creature’s body was not outside…
In episode 8, the gang recalls how Vecna’s spooky grandfather clock always chimes four times, and they take that to mean that he must have to kill four victims in order to enact his grand plan of unleashing Demogorgons and the like in the real world. Turns out, while she may have only crossed over for sixty seconds, Max’s “death” counted, and it resulted in a devastating earthquake that saw 22 locals lose their lives and glowing, wound-like gateways popping up all over town. It seemingly revived Vecna, too.
“Now that I’m here, in Hawkins, I can feel him,” Will tells Mike, referencing his somewhat dormant connection to the Upside Down. “And he’s hurt, he’s hurting, but he’s still alive. It’s strange knowing now who it was this whole time, but I can still remember what he thinks, and how he thinks, and he’s not going to stop… ever… not until he’s taken everything and everyone. We have to kill him.”
What happened to Dr. Sam Owens?
Unlike the other characters’ mentioned here, Dr. Sam Owens’ fate is unclear. He last appeared in episode 8, after Brenner handcuffed him to a pipe in The Nina Project bunker, and Sullivan threatened him before setting his sights on Eleven.
While Eleven managed to take down the army’s helicopter before it could dispatch her, and it exploded right on top of one of the silo’s entrances, he was underground, so it’s not likely he would’ve been caught up in the blast. Might he show up again in season 5? Only time will tell. Hopefully someone remembers he’s down there…
For more on Stranger Things, check out our explainer on the Stranger Things season 4, Volume 2 ending, and our rundown of the biggest Stranger Things season 4, Volume 2 Easter eggs and references. If you’ve binge-watched the whole chapter and are stuck on what to watch next, check out the best Netflix shows and the best Netflix movies available right now.
Volume 606 Issue 7914, 16 June 2022
Living the high life
The cover image shows plants growing at altitude on Altar Volcano in Chimborazo, Ecuador. Extreme altitudes pose challenges for most forms of life, and flowering plants are no exception. But flowering plants have been found growing as high as 6,400 metres above sea level. In this week’s issue, Michael Holdsworth and his colleagues reveal a molecular mechanism that helps plants to adapt to the extremes of altitude. The researchers studied a range of plants, representing four diverse clades of flowering plants — thale cress (Arabidopsis thaliana), tomato, poppy and the grass Brachypodium distachyon. They found that plants use genetic adaptations to adjust their sensitivity to atmospheric oxygen, whose partial pressure decreases with altitude. By decoding the ambient oxygen level, the plants are able to sense the altitude at which they grow and optimize internal biochemical processes.
Cover image: Cristian Miño, Ecuador.
Mortgage Volume Gets Crushed by Spiking Interest Rates: What it Means for Future Home Sales and Consumer Spending
The boom is over. And there are broader effects.
By Wolf Richter for WOLF STREET.
Spiking mortgage rates multiply the effects of exploding home prices on mortgage payments, and it has taken layer after layer of homebuyers out of the market for the past four months. And we can see that.
Mortgage applications to purchase a home fell further this week and were down 17% from a year ago, hitting the lowest level since May 2020, according to the Mortgage Bankers Association’s weekly Purchase Index today. The index is down over 30% from peak-demand in late 2020 and early 2021, which was then followed by the historic price spikes last year.
“The drop in purchase applications was evident across all loan types,” the MBA’s report said. “Prospective homebuyers have pulled back this spring, as they continue to face limited options of homes for sale along with higher costs from increasing mortgage rates and prices. The recent decrease in purchase applications is an indication of potential weakness in home sales in the coming months.”
The culprit of the plunge in volume: The toxic mix of exploding home prices and spiking mortgage rates. The average interest rate for 30-year fixed rate mortgages with 20% down and conforming to Fannie Mae and Freddie Mac limits, jumped to 5.37%, the highest since August 2009, according to the Mortgage Bankers Association’s weekly measure today.
What this means for homebuyers, in dollars.
The mortgage on a home purchased a year ago at the median price (per National Association of Realtors) of $326,300, and financed with 20% down over 30 years, at the average rate at the time of 3.17%, came with a payment of 1,320 per month.
The mortgage on a home purchased today at the median price of $375,300, and financed with 20% down, at 5.37% comes with a payment of $1,990.
So today’s buyer, already strung out by rampant inflation in everything else, would have to come up with an extra $670 a month – that represents a 50% jump in mortgage payments – to buy the same house.
Now figure this with homes in the more expensive areas of the country where the median price, after the ridiculous spikes of the past two years, runs $500,000 or $1 million or more. Homebuyers are facing massively higher mortgage payments in those markets.
The combination of spiking home prices and spiking mortgage rates has the effect that layers and layers of buyers are leaving the market. And we’re starting to see that in the decline of mortgage applications.
The Fed has caused this ridiculous housing bubble with its interest rate repression, including the massive purchases of mortgage-backed securities and Treasury securities.
And the Fed is now trying to undo some of it by pushing up long-term interest rates. It’s the Fed’s way – too little, too late – of trying to tamp down on the housing bubble and on the risks that the housing bubble, which is leveraged to the hilt, poses for the financial system.
What it means for consumer spending.
When mortgage rates fall, homeowners tend to refinance their higher-rate mortgages with lower-rate mortgages, either to lower their monthly payment, or draw cash out of the home, or both.
The wave of refis that started in early 2019, as the Fed did its infamous U-Turn and mortgage rates declined, became a tsunami starting in March 2020, as mortgage rates plunged to record lows over the next few months. Homeowners lowered their monthly payments, and spent the extra cash that the lower payments left them. Other homeowners extracted cash via cash-out refis and spent this money on cars and boats, and they paid down their credit cards to make room for future spending, and this money was recycled in various ways and boosted the economy. And some of it too was plowed into stocks and cryptos.
This effect ended months ago. By now, applications for refinance mortgages collapsed by 70% from a year ago, and by 85% from March 2020. Refis no longer support consumer spending, stocks, and cryptos.
What it means for the mortgage industry.
Mortgage bankers know that they’re in a highly cyclical business. Faced with rising mortgage rates, and collapsing demand for refis, and lower demand for purchase mortgages, the mortgage industry has started laying off people.
Add Wells Fargo, one of the largest mortgage lenders in the US, to the growing list of mortgage lenders that have reportedly started the layoffs late last year and so far this year, including most notoriously Softbank-backed mortgage “tech” startup Better.com, but also PennyMac Financial Services, Movement Mortgage, Winnpointe Corp., and others.
Wells Fargo confirmed the layoffs last Friday and a statement blamed the “cyclical changes in the broader home lending environment,” but didn’t disclose in which locations of its far-flung mortgage empire it would trim mortgage bankers, and how many.
So that boom is over. And the Fed has just now begun to push up interest rates, way too little and way too late, but it is finally plodding forward in order to deal with this rampant four-decade high inflation, after 13 years of rampant money-printing – an inflation of the magnitude the majority of Americans has never seen before.
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Cincinnati Reds’ Hunter Greene sets velocity volume record in loss to Los Angeles Dodgers
LOS ANGELES — On a cool Southern California evening, Cincinnati Reds rookie Hunter Greene brought some record-setting heat.
After five overpowering innings, the Los Angeles Dodgers finally caught up.
Trea Turner launched a two-run homer to snap a scoreless tie in the sixth and the Dodgers beat the skidding Reds 5-2 on Saturday night for their fifth consecutive victory.
In his highly anticipated homecoming, Greene threw an astounding 39 pitches 100 mph or faster — most in a single game since pitch tracking began in 2008. The previous mark was 33 by New York Mets ace Jacob deGrom last June.
Making his second major league start, the 22-year-old right-hander, who went to high school in nearby Sherman Oaks, also fired 13 pitches at least 101 mph — another record for a starter.
The moment finally hit Greene in the third inning, but only emotionally. He said he became teary-eyed on the bench amid the enormity of the occasion, and was choked up after walking off the mound in the sixth.
“I wish we would have come out with a win, but it was a really, really fun time,” Greene said. “It was an unbelievable feeling and experience to go against that lineup. Freddie [Freeman] gave me some love, kind of a tip of the cap, so that was cool. I was happy to be able to do that here and have family here.”
But with Greene’s velocity dipping slightly later in his outing, it was a 99 mph fastball to Turner that ended up in the left-field seats.
“We still had to be ready for 99 with a pretty good slider and decent changeup,” Turner said. “He’s tough no matter how hard he’s throwing, whether it’s 99 or 101, but I think we did a good job battling.”
Turner finished with three hits, including an infield single in the first. The speedy shortstop has a hit in all eight games this season, and in 27 straight going back to last year. It is the third-longest hitting streak in the team’s Los Angeles history.
Dodgers starter Julio Urías, his velocity down during the spring and through his first outing of the season, managed to outpitch Greene by giving up one hit over five shutout innings.
The Reds didn’t get their first hit until Tyler Stephenson ripped a single past second baseman Max Muncy in the fifth. An inning later, the Dodgers finally broke through.
Austin Barnes led off the sixth against Greene with a single. Turner followed by hitting a 1-1 fastball halfway up the bleachers in left field for his first home run of the season.
Freeman followed with a strikeout but reached first base on Stephenson’s passed ball. Justin Turner popped out and Reds manager David Bell replaced Greene with right-hander Buck Farmer.
The Dodgers added two more runs, one charged to Greene, when Chris Taylor hit a two-run single with two outs.
“He wasn’t really going to give us anything, so we had to earn it,” Turner said. “He kept us down the first 5 1/2 innings and we finally got to him. But he’s really good and I’m glad we came out with the win.”
Greene (1-1) gave up three runs (two earned) on five hits in 5⅓ innings, with no walks and six strikeouts. He threw 80 pitches.
The Reds lost their fifth consecutive game – their last victory came last Sunday when Greene made his major league debut in Atlanta.
At first, Greene said he cried on the bench in the third inning.
“I didn’t cry, that was just a poor choice of words,” he said with a laugh. “I just teared up a little bit.
“I was sitting on the bench and it just randomly hit me. I think I looked up and I could hear the roar and the feeling of it. … Up here, it’s a totally different atmosphere. And to be here at Dodger Stadium as a kid, I think all of those factors played into that moment.”
The big stage didn’t shake him on the field. Even the home run from Turner came on a pitch at the edge of the plate.
“Usually it takes a little longer to find that [composure] for a young player,” Bell said. “He’ll have his moments, but to have the experience he’s had is speeding up that development.”
Freeman added a sacrifice fly in the seventh to make it 5-0.
Urías walked one and struck out five. He was in the 92 mph range with his fastball after sitting at 91 in his season debut. He still is down from his 94 mph average velocity during his 20-win season of 2021.
The Reds got on the scoreboard in the ninth with an RBI groundout by Taylor Naquin and an RBI single from Tommy Pham off reliever Mitch White.
Daniel Hudson got two outs for his first save this season.
Evan Phillips (1-1) earned the win with a scoreless sixth inning.
DEAL MAKERS
The Reds sent right-hander Riley O’Brien to Seattle for a player to be named or cash. O’Brien was designated for assignment Wednesday to make room on the 40-man roster for left-hander Nick Lodolo.
TRAINER’S ROOM
Reds: INF/OF Nick Senzel was placed on the COVID-19 injured list Friday, although Bell said Senzel has not tested positive. Senzel began feeling ill before Friday’s game. RHP Daniel Duarte was recalled from Triple-A Louisville. … While the hamstring strain for 2B Jonathan India continues to improve, the Reds will wait until Sunday to decide if an IL move is necessary.
Dodgers: RHP Tommy Kahnle, who has just one major league outing since 2019 after having Tommy John surgery, made his third consecutive scoreless rehab outing at Class A Rancho Cucamonga on Friday.
UP NEXT
Reds: RHP Tyler Mahle (1-0, 1.00 ERA) makes his third start of the season in the series finale Sunday. He is 2-1 in four starts against the Dodgers with a 2.05 ERA.
Dodgers: LHP Andrew Heaney (0-0, 0.00) will pitch at home with his new team for the first time after throwing 4⅓ scoreless innings at Minnesota on Tuesday.