Tag Archives: vaccinating

A box of 200 mosquitoes did the vaccinating in this malaria trial. That’s not a joke!

One Seattle morning, Carolina Reid sat in a room with nine other volunteers, each waiting to take part in a clinical trial for a new, experimental malaria vaccine.

Reid’s turn came. She put her arm over a cardboard box filled with 200 mosquitoes and covered with a mesh that keeps them in but still lets them bite. “Literally a Chinese food takeout container” is how she remembers it. A scientist then covered her arm with a black cloth, because mosquitoes like to bite at night.

Then the feeding frenzy began.

“My whole forearm swelled and blistered,” says Reid. “My family was laughing, asking like, ‘why are you subjecting yourself to this?'” And she didn’t just do it once. She did it five times.

You may be thinking – this is a joke, right?

Reid’s arm swelling after being bitten by 200 mosquitoes at once in order to be dosed with the experimental malaria vaccine.

But it’s not. “We use the mosquitoes like they’re 1,000 small flying syringes,” explains University of Washington, Seattle physician and scientist Dr. Sean Murphy, lead author on a paper in Science Translational Medicine released on August 24 detailing the vaccine trials.

The insects deliver live malaria-causing Plasmodium parasites that have been genetically modified to not get people sick. The body still makes antibodies against the weakened parasite so it’s prepared to fight the real thing.

To be clear, Murphy’s not planning to use mosquitoes to vaccinate millions of people. Mosquitoes have been used to deliver malaria vaccines for clinical trials in the past, but it’s not common.

He and his colleagues went this route because it is costly and time consuming to develop a formulation of a parasite that can be delivered with a needle. The parasites mature inside mosquitoes so at this proof of concept stage – as early stage trials are called — it makes sense to use them for delivery.

“They went old school with this one,” says Dr. Kirsten Lyke, a physician and vaccine researcher at the University of Maryland School of Medicine who was not involved in the study. “All things old become new again.”

She calls the use of a genetically modified live parasite “a total game changer” for vaccine development.

This type of vaccine is of course not yet ready for prime time. But the small trial of 26 participants did show that the modified parasites protected some participants from a malaria infection for a few months.

Murphy believes this approach could someday result in a vaccine that’s substantially more effective than the world’s first malaria vaccine, the RTS,S vaccine from drugmaker GlaxoSmithKline. The World Health Organization approved it last year, but it only has an efficacy rate of 30-40%.

Mosquitoes and malaria – a toxic relationship

Reid was looking for work when she joined the trial in 2018. “The first thing that caught my eye was the money,” she says — a $4,100 payment for participants. But when she spoke to friends who’d contracted malaria, she found a different motivation. She said it was no longer about the money at that point – though it was still nice – but instead being a part of important research.

Dr. Tony Brain/Science Source

A colored microscope image of the malaria parasite, Plasmodium sp. (green), infecting a red blood cell (red). Malaria is spread from infected Anopheles mosquitoes to people. The parasites infect the liver, then move into the blood.

Malaria parasites live in the salivary glands of Anopheles mosquitoes. The disease is most common in Africa where the warm climate suits the growth of the parasite. People get malaria from the bite of an infected mosquito. Infected people can pass the malaria parasite to mosquitoes who bite them, and the cycle of infection continues.

Countries try to curb malaria with mosquito netting, insecticidal sprays, anti-malarial drugs and even by releasing genetically modified mosquitoes that can’t bite or lay eggs.

Even with those measures, scientists estimate there are over 240 million cases of malaria a year and over 600,000 deaths – which is why vaccines are needed.

A promising start – but there’s room for improvement

The reason Murphy thinks this experimental vaccine should stimulate a more powerful immune response than the WHO-approved RTS,S vaccine is that it uses a whole weakened parasite. RTS,S targets “just one out of more than 5,000 proteins” the parasite produces, he says.

Others have attempted to make a malaria vaccine from disarmed parasites. What’s new is that this team did the disarming with CRISPR – a highly advanced pair of molecular scissors that can cut DNA.

To test how well the approach worked, Reid and the other participants had to get another round of mosquito bites — this time containing the real malaria parasite.

Out of 14 participants who were exposed to malaria, seven of them — including Reid – came down with the disease, meaning the vaccine was only 50% effective. For the other seven, protection didn’t last more than a few months.

“I actually cried when they told me I had malaria because I developed such a close relationship with the nurses,” Reid says. She wanted to continue through the trials, but her infection made her ineligible. She was given a drug to clear her case of malaria and sent home.

“We think we can obviously do better,” says Stefan Kappe, an author of the study and parasitologist at University of Washington Seattle and Seattle Children’s Research Institute. He and Murphy hope to improve the efficacy of their team’s vaccine by putting it into syringes instead of using mosquitoes so they can get the dosage right. A higher initial dose could lead to greater protection for a longer period of time.

Lyke says some scientists think using a slightly more mature version of the parasite than the one in this vaccine could give the body more time to prepare an immune response. The team is already working on that approach, says Kappe.

If future trials are promising, there are other questions to ponder. For starters: How much would this type of vaccine cost? The scientists are partnering with a small company called Sanaria to produce the modified parasites. Kappe says that increasing production capability to scale up manufacturing will require investment.

As for Reid, her experience was so positive that she went on to participate in clinical trials for a bird flu vaccine and the Moderna COVID-19 vaccine. She says that she will continue to enroll in vaccine clinical trials “for the rest of my life actually.”

Copyright 2022 NPR. To see more, visit https://www.npr.org.

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U.S. to begin vaccinating young children against covid

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Eighteen months after a New York nurse received the first U.S. coronavirus vaccination, immunizations became available Tuesday for millions of children between the ages of 6 months and 5 years, the last group of Americans to be afforded that protection.

Pediatricians, drugstores, hospitals and community vaccination centers began to administer first doses of two vaccines to children: the Pfizer-BioNTech product to children ages 6 months through 4 years; and the Moderna vaccine to children 6 months through 5 years old.

Some parents rushed to get the vaccine early Tuesday morning. In Washington, D.C., Chinmay Hegde’s 14-month-old daughter Ada was the first child to receive a shot Tuesday morning at Children’s National Hospital. She winced as the needle went in, but it wasn’t as bad as her routine vaccinations.

“The last time we came here she ended up getting five shots in the same day,” Hegde said. “I think the fact that there was only one, she was like, ‘Oh great, good deal.’ ”

At a city-run covid center on U Street, a line of parents and strollers snaked around the corner as Asia Perazich waited with her 3-year-old son Mica and 1-year-old daughter Zia.

“I wish it had happened sooner,” Perazich said as Mica doodled in a watercolor book. “It’ll be nice to be able to take them to a restaurant and not worry.”

In Houston, Jim Versalovic, pathologist-in-chief at Texas Children’s Hospital, said: “We began vaccinating the first children at 6 a.m. We have shots in arms now. We have hundreds of children lining up, and our goal is to get this vaccine to thousands of children in the greater Houston area and Texas.

“The children are handling it as well or better than the adults,” he added.

President Biden spoke Tuesday afternoon at the White House, calling the development affecting as many as 19 million children nationwide “a very historic milestone, a monumental step forward.” He said the United States is now the first nation to offer vaccine to children as young as six months and urged parents to get their children vaccinated. Biden earlier visited a city-run coronavirus center where vaccines were being offered to children.

Nancy Wyss of Chicago said she scheduled an appointment to vaccinate her 3-year-old daughter next week. Wyss said she has been waiting for this moment for the “health and protection” of her daughter and so the family can feel safer when they visit the girl’s grandparents.

Wyss said the vaccine will also help “my own sanity.” Wyss said her daughter’s day care currently closes if a child or teacher gets coronavirus; once children are vaccinated they will keep the center open if there is a case. The vaccine will also ease Wyss’s worries about flying.

“We are going on a trip at the beginning of August, so it makes us more comfortable flying with her and seeing her grandparents. It’s exciting. We’ve been waiting a long time,” she said.

For parents who have been eager to vaccinate their children, Tuesday was the end of a long, difficult period when babies, toddlers and preschool-aged children did not have access to vaccines that have proved highly effective in preventing death and hospitalization for the rest of the population.

But a Kaiser Family Foundation Covid-19 Vaccine Monitor poll released in May found them to be a distinct minority. Eighteen percent of parents with children younger than 5 said they were eager to get the youngsters vaccinated immediately. More than a third of parents — 38 percent — said they planned to see how the vaccine works in other children, and 27 percent reported they would “definitely not” have their children vaccinated. Eleven percent said they would do so if required.

The survey was taken before the Food and Drug Administration found the vaccines safe and effective for the youngest children and the Centers for Disease Control and Prevention gave them the green light Saturday.

In some places, there was an initial rush for appointments. “It really has only been about 24 hours since vaccine was delivered and our call center has been inundated with phone calls about getting this vaccine,” said Mary Zimmerman, a nurse and immunizations specialist for Spectrum Health in Michigan.

In New York, there was a one-day delay while vaccine sites awaited final approval from the state Health Department. Matthew Harris, a pediatric emergency medicine physician at Cohen Children’s Medical Center in Queens and medical director of the coronavirus vaccine program at Northwell Health, said vaccinations for children under 5 in New York City would likely begin Wednesday.

Florida, which refused to preorder vaccine until the administration of Gov. Ron DeSantis (R) backed off and allowed doctors to request it Friday, is unlikely to see any vaccinations until later this week, according to the state Department of Health. The state government, which does not recommend the vaccine for healthy children, was the only one in the nation not to preorder the vaccine.

Biden on Tuesday said that “elected officials shouldn’t get in the way and make it more difficult,” for parents who want to see their children vaccinated. “This is no time for politics.”

About 13.5 million children have tested positive for the virus, according to the American Academy of Pediatrics, offering them some protection against it. According to federal health data that analyzed blood tests, the number is even higher — by the end of February it showed that 3 out of 4 children nationwide had been infected with the coronavirus.

Tracking coronavirus cases

But health authorities say all children should be vaccinated, because it is the best way to provide children with durable protection and reduce the chances of another infection and complications.

Children are less likely than other people in other age groups to become seriously ill from the virus, but they are not invulnerable. More than 1,000 have died, more than 40,000 have been hospitalized and more than 8,500 have suffered a condition called multisystem inflammatory syndrome in children (MIS-C), which can cause inflammation of the heart, lungs, kidneys, brain, eyes and other organs, according to the CDC.

Houston parent Brittany Kruger said Tuesday that she will not be getting her children vaccinated.

“My children have had covid, and the only reason we knew is because we had it. So we tested them. They showed no symptoms, much like the majority of children we know,” she said. “I feel that my children, at their ages, have very little risk of side effects from covid. In fact, I am more fearful of what a shot that’s newer to the market would do in the long term.”

But Amisha Vakil, who has twin 3-year-olds, Jiyan and Kian, one of whom is at high risk awaiting a heart transplant, was at Texas Children’s at 6:30 a.m. to have both children vaccinated.

“Getting both of my children vaccinated today means a lot for us, especially to give Jiyan that shield, a little armor,” she said.

“For two years we’ve pretty much been in quarantine,” she added. “We couldn’t send them to preschool or any activities. Kian stayed home, too, because he might bring something home with him.”

Tracking the coronavirus vaccine

Almost 67 percent of the U.S. population is vaccinated — a proportion that has barely increased in recent months despite the efforts of government and private health officials. The virus has killed more than 1 million Americans, the largest known total of any nation in the world.

At Seattle Children’s Hospital, parents and their children stood for 15 minutes outside the vaccination room. Some children had barely said their first words, and restless others darted up and down the corridors. The hospital was prepared; the Seattle Storm mascot Doppler arrived to give children a 7-foot, red and yellow, shaggy distraction.

Erin Murphy, who was at the hospital with her 3-year-old son, said covid protections kept him from attending his great-grandfather’s funeral, and he stayed home with his father. Now, the boy joined his family in being vaccinated, and has documentary evidence to prove it.

“Everyone got a photo when they got vaccinated, and now he has his own,” Murphy said.

Edwin Lindo, who teaches critical race theory at the University of Washington School of Medicine, was among the first in line and sees the vaccination of his two young children as a step against the inequities exposed by the pandemic. When his 8-month-old son was infected two months ago, “It was scary,” he said. Lindo brought the baby to the hospital during his illness — and brought him back Tuesday to get vaccinated.

“This is our way to fight and say that we’re not going to be the product of legacies of racism, we’re not going to succumb to being a statistic. We’re going to live another day to fight, so that we can actually change the outcomes of our community,” Lindo said.

Mark Del Beccaro, assistant deputy chief of coronavirus testing and immunization programs at the Seattle and King County Public Health office, said he expects that vaccinations for young children will surge in the next month, then drop off as more families are hesitant about the effects on younger children. King County is among the most vaccinated counties in the United States.

“It’s a great time to be vaccinated, so that people can be less worried about family gatherings, and just as importantly be prepared for the fall, when everyone will be driven back inside again,” Del Beccaro said.

Katie Shepherd in Washington, Mark Guarino in Chicago, Ken Hoffman in Houston, Barbara Liston in Orlando, Ian Morse in Seattle and Jack Wright in New York contributed to this report.

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Vaccinating Migrants; WHO Eyes Possible COVID Vax-Tinnitus Link; Medical Gaslighting

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The Biden administration plans to offer COVID-19 vaccines to migrants entering the U.S. from the southern border. (CNN)

The World Health Organization is examining rare reports of sudden hearing problems — such as tinnitus or loss of hearing — following COVID-19 vaccination. (NBC News)

London police doled out multiple fines for lockdown parties at Prime Minister Boris Johnson’s Downing Street residence and other government facilities. (Axios)

As Shanghai tests all its citizens for COVID-19, it’s finding that the vast majority are asymptomatic or presymptomatic. (Reuters)

After the introduction of vaccines in the U.S., COVID-19 deaths in red states were 38% higher than blue states. (ABC News)

As of Tuesday at 8 a.m. EDT, the unofficial U.S. COVID toll was 80,050,348 cases and 981,093 deaths, increases of 43,581 cases and 942 deaths from this time a day ago.

Average deaths in the U.S. have fallen to their lowest point since last summer. (The Hill)

Globally, the BA.2 Omicron subvariant is now the dominant COVID strain. (Reuters)

HIV antivirals — specifically protease inhibitors — may protect against COVID-19 infection, according to a French study of people living with HIV. (UPI)

Oregon will stop requiring that people seeking medically assisted suicide be residents of the state. (AP)

If Roe v. Wade is significantly weakened by the Supreme Court, Colorado is expecting to become a hub for out-of-state women seeking abortions. (NPR)

What is “medical gaslighting” and what groups are most affected? (New York Times)

The FDA approved the EVO/EVO+ Visian Implantable Collamer lens for correcting myopia with or without astigmatism, STAAR Surgical announced.

Meanwhile, Novo Nordisk said the agency approved a once-weekly 2-mg dose subcutaneous semaglutide (Ozempic) for type 2 diabetes based on results of the SUSTAIN FORTE trial.

How large a role did former Google CEO Eric Schmidt have in influencing the Biden administration’s science office? (Politico)

Fired emergency medicine doctor Ray Brovont warns about the role of private equity in healthcare. (NBC News)

  • Ian Ingram is Managing Editor at MedPage Today and helps cover oncology for the site.

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Scientists are proposing a reboot on vaccinating the world – HotAir

“We seem to have lost perspective as to what the major goal of vaccines is and where they are going to yield the greatest public health benefit,” says Shabir Madhi, a prominent vaccine researcher at South Africa’s University of Witwatersrand.

Specifically, Madhi argues that governments in countries that still have low vaccination rates should shift their attention to vaccinating those who are most vulnerable to severe disease from the coronavirus. That means people age 50 and above or those with health conditions that put them at particular risk. The aim, says Madhi, should be to get 90% or more of people in this category vaccinated.

Unfortunately, he says, that effort is being hampered by a simultaneous push to meet a different goal – vaccinating 70% of all adults regardless of age or health status. It’s an objective originally conceived by the World Health Organization, then embraced and promoted by the United States. But, says Madhi, it’s a goal that could now be proving a harmful distraction.

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Israel starts vaccinating young children as coronavirus cases rise

JERUSALEM, Nov 22 (Reuters) – Israel began rolling out Pfizer/BioNtech COVID-19 vaccinations for 5- to 11-year-olds on Monday hoping to beat down a recent rise in coronavirus infections.

A fourth wave of infections that hit Israel in June began subsiding in September. But over the past two weeks the “R”, or reproduction rate of the virus, that had remained below one for two months began climbing and has now crossed that threshold, indicating the virus could again be spreading exponentially.

Daily cases have also crept up over the past few days, with half the confirmed infections presently among children age 11 and younger.

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The children’s vaccine drive kicked off on Monday in a Tel Aviv square, where a small number of parents quietly lined up with their children to get shots. The campaign will go nationwide on Tuesday.

“The kids go to school, they (mix) with (other) kids, and they are doing a lot of social activities. We are very excited (to) vaccinate them and get (back) to normal life,” said Katy Bai Shalom, whose son and daughter were vaccinated Monday.

Receiving their shots in front of television cameras, some of the children smiled and laughed, while others teared up and held on to their parents.

Israel’s 9.4 million population is relatively young, with around 1.2 million children in the 5-to-11 age group. By November, that group comprised more than a third of new cases, according to health ministry data. Scientists and officials have been doubtful the country can reach “herd immunity” unless children are vaccinated.

Noam Kleinmann, 10, chats with the nurse while he receives his first coronavirus disease (COVID-19) vaccination after country approves vaccinations for children aged 5-11, in Tel Aviv, Israel November 22, 2021. REUTERS/Corinna Kern

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Policy makers also say that the vaccination of younger children is meant first and foremost to protect their individual health and not just to stop the transmission of the virus.

In the past week they have stressed that although COVID-19 is rarely severe among young children and many show no symptoms at all, it can carry risks in the longer term.

Israel’s health ministry estimates that one in 3,500 children infected with the coronavirus will later develop Multisystem Inflammatory Syndrome in Children (MIS-C) in which parts of the body become inflamed, including the heart, lungs, kidneys, brain, skin and gastrointestinal organs. Most children who suffer from the condition require intensive care treatment and 1-2% die.

Officials have also noted the risk of lingering symptoms, such as sleep disruption, muscle pain, loss of smell and taste, headaches and a cough, commonly known as “long Covid”.

A survey by the health ministry of more than 13,000 children showed that around 11% had suffered lingering symptoms, with about 1.8% to 4.6%, depending on their age, continuing to experience symptoms six months after becoming ill.

A poll by Israeli healthcare provider Maccabi found that 41% of parents to children age 5 to 11 were positive they will vaccinate their children, while 21% were still undecided and 38% will not vaccinate their children.

Israel has recorded 1.3 million total confirmed cases and more than 8,000 dead since the start of the pandemic.

Around 57% of Israel’s population is fully vaccinated, according to the health ministry, which means they have either received a third shot or it has not yet been five months since they received their second.

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Additional reporting by Rami Amichay in Tel Aviv; Editing by Angus MacSwan and Howard Goller

Our Standards: The Thomson Reuters Trust Principles.

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For parents finally vaccinating kids under 12, ‘excitement and happiness and relief’

On the morning after Covid-19 shots were recommended for children ages 5 to 11, Karen Bucher woke up at dawn to secure a vaccination appointment for her daughter, Margot, a social 8-year-old who has had just one indoor play date since the pandemic hit. 

As Bucher, of Chicago, booked the slot, she felt tears welling up as she realized the significance of the appointment not just for Margot, but for the rest of their family, too. 

Karen Bucher with her kids, Calvin, 13, and Margot, 8. Karen Bucher

Bucher, her partner and Bucher’s 13-year-old son are already vaccinated. While awaiting Margot’s turn to get her shot, the family lived nearly as cautiously as they did before.“We still had to protect her, so nothing changed. The kids haven’t been inside a restaurant or a grocery store since February 2020,” said Bucher, a medical illustrator for JAMA: The Journal of the American Medical Association. “I know the vaccines are very protective of hospitalization and death, but that doesn’t mean that we can’t give it to her if we were to get sick.”

With the Centers for Disease Control and Prevention’s endorsement last week of a Covid vaccine for children in the 5 to 11 age group, parents of young kids say they feel a rush of relief and hope about their families’ futures.

A vaccine still has yet to be approved for children under age 5. But among the 28 million children ages 5 to 11 in the U.S., many parents, at last, see a path forward out of the pandemic.

Some are planning long-delayed family vacations. Others are looking forward to bringing children along again on mundane errands. And others are excited to bring back hallmarks of their kids’ childhoods that vanished with the pandemic: softball practice, gymnastics meets, soccer games.

“It’s a green light to start to figure out how we go back to a new normal,” said Bucher, who booked Margot’s first shot for this Thursday. “I think people who don’t have kids went through that transition months ago.’”

Chris Ware, the father of three kids ages 7, 9 and 11, will feel the relief the most each morning when he drops his kids off at their elementary school. The school has no mask mandate, so Ware, of Saginaw, Michigan, worries constantly about their health.

“It’s a little bit less likely that kids are getting to the point that kids are in the hospital, but I just couldn’t live with myself if that happened,” he said. 

Ware’s kids will also get their first shots Thursday.

“It’s definitely going to be emotional for us,” he said. “I care about their well-being more than anything.” 

‘I didn’t realize how much stress I was carrying around’

Some parents only felt the weight of how taxing it has been to get vaccinated before their children when they finally were able to schedule their kids’ shots.

“I didn’t realize how much stress I was carrying around,” said Krishna Mudumbi, a research scientist who lives in Wethersfield, Connecticut, and is the father of two children, ages 7 and 8.

Krishna Mudumbi with his kids, Aaryan, 8, and Leela, 7. Courtesy Krishna Mudumbi

The kids got their first doses Saturday. For Mudumbi, it was a step toward no longer worrying about whether they would get exposed to the coronavirus at school, whether he and his wife would have to change their work schedules to stay home with them if they were quarantining, getting Covid tests before going to visit the grandparents and other inconveniences that had become regular parts of the family’s lives.

“There were just a lot of things that became a new concern in our minds, and now we’re seeing a little bit of normalcy,” Mudumbi said.

It’s a response many parents are likely to have, said psychologist Lynn Bufka, the senior director of practice transformation and quality at the American Psychological Association.

“We want to raise our children to be healthy adults, and for almost two years it has felt to many parents like there’s something bad and scary out there that can harm their kids that they can’t see, they don’t know where it is, and they have very few ways to protect their children from it,” she said.

“And then living with the day-to-day consequences of it — children not hugging their grandparents, children not having sleepovers, children’s schooling disrupted — not all parents want to get their children vaccinated, but for those who do, they feel like ‘there’s something I can do,’” she added.

Mudumbi’s kids will be fully vaccinated in time for the winter holidays, and they look forward to visiting family. They also plan to eventually go to New York City, a place the kids have long wanted to take a trip to.

A ripple effect for the rest of the family

It’s not just parents who will feel the ripple effect from their youngsters’ getting Covid shots. In many households, siblings, too, will benefit. 

Amy Eklund, of north Alabama, is the mother of three children, two of whom were already old enough to get vaccinated. Last weekend, she took her youngest child, Aaron, 10, to get his first shot. 

Aaron Eklund, 10, after receiving his first Covid vaccination.

His date of birth was blurred out from the card by NBC News.

Courtesy Amy Eklund

That will open doors for Aaron’s siblings: his sister Hannah, 13, got her shot nearly six months ago and wanted to participate in her school’s chorus, but with Aaron still unvaccinated, Eklund was too nervous to allow her to join, fearful she might bring Covid into their household.

“For me, it’s pure excitement and happiness and relief and just ‘yay, we’ve done it!’” Eklund said of getting Aaron his first shot. 

The shot went well, she said. Aaron was nervous, but he said it hurt less than the flu shot he got a month ago.

“He is relieved,” Eklund said. “He is very excited to finally be done and not have to worry about getting sick.”

For Bucher, who, as a medical illustrator, has been closely following the research around Covid, having a fully vaccinated family means they’re doing their part to keep their community safe. It also means the return of activities they loved before the pandemic, such as going out for dinner. 

And play dates will be back for 8-year-old Margot.

“Just to know that she has an added layer of protection very soon, it’s such a relief,” Bucher said. “I think that’s where the tears come from as much as the excitement: It’s just pure relief.”

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Vaccinating UK girls against HPV slashed cervical cancer rates, study finds

Vaccinating girls against HPV has dramatically reduced cervical cancer rates, British researchers have found. 

In a study published last week in The Lancet, the researchers followed the outcome of the Cervarix vaccine, which was introduced in England in 2008 and protects against the two most common types of HPV.

US CERVICAL CANCERS FALL BUT OTHER SEX-RELATED CANCERS RISE

Using data from a population-based cancer registry between January 2006 and June 2019, the study looked at seven groups of women between the ages of 20 and 64.

Cervarix protects against two strains of human papillomavirus, or HPV, which can cause cancer. Since 2012, the U.K. has also been using another vaccine called Gardasil that protects against four types of HPV and was not evaluated in the paper.

In the study, three vaccinated cohorts were compared with earlier cohorts that were not eligible for HPV vaccination. 

A type of Gardaisl is currently the only vaccine distributed in the U.S.
(Credit: iStock)

The study found that cervical cancer rates were 87% lower in girls getting the shot at age 12-13, 62% lower in girls 14-16 and 34% lower in girls 16-18, compared with previous unvaccinated generations.

“We estimated that by June 30, 2019, there had been 448 fewer than expected cervical cancers and 17,235 fewer than expected cases … in vaccinated cohorts in England,” the researchers wrote.

WHO LAUNCHES STRATEGY TO EXPEDITE END OF CERVICAL CANCER

“It’s been incredible to see the impact of HPV vaccination, and now we can prove it prevented hundreds of women from developing cancer in England. We’ve known for many years that HPV vaccination is very effective in preventing particular strains of the virus, but to see the real-life impact of the vaccine has been truly rewarding,” Peter Sasieni, the lead author, said in a statement to King’s College London.

“Assuming most people continue to get the HPV vaccine and go for screening, cervical cancer will become a rare disease. This year we have already seen the power of vaccines in controlling the COVID-19 pandemic. These data show that vaccination works in preventing some cancers,” he said. 

According to the World Health Organization, there are more than 100 types of HPV, of which at least 14 are cancer-causing. 

Cervical cancer is the fourth most common cancer among women globally, with an estimated 570,000 new cases in 2018.

In the U.S., the Centers for Disease Control and Prevention reports that HPV is the most common sexually transmitted virus, with about 43 million infections reported in 2018.

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Cancer may take decades to develop after a person is infected with HPV.

A type of Gardasil that protects against nine types of HPV is currently the only vaccine distributed in the U.S., according to the CDC.

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Even after federal authorization, vaccinating America’s children will present challenges.

Image
Credit…Rosem Morton for The New York Times

Approximately 28 million American children will be newly eligible for Pfizer-BioNTech’s coronavirus vaccine as soon as this week, if the Centers for Disease Control and Prevention clears the shots for those ages 5 to 11.

The Food and Drug Administration authorized those pediatric doses on Friday. After a review from an advisory panel, the C.D.C. will issue its guidance.

But getting shots in arms takes more than official permission, and the federal government, state and local officials, and health care institutions are working to ensure that vaccines are available for children across the country.

The Biden administration said last week it had 15 million doses ready to ship immediately, and that it would make them accessible at children’s hospitals, pharmacies, community health centers and pediatricians’ offices. States started ordering doses, free of charge, last week based on the number of children they count in the age group.

California’s Department of Public Health said in an email on Friday that the state had initially ordered approximately one million doses, and planned to request more soon. The vaccines will be made available to the state’s 3.5 million newly eligible children at thousands of sites, including medical practices, pharmacies and schools.

In Illinois, Gov. J.B. Pritzker said on Monday that more than 2,200 locations and providers were already prepared to provide the more than 500,000 pediatric doses that the state will initially receive.

State health officials in Texas said on Monday that the federal government would initially allocate approximately 1.3 million pediatric doses to the state.

Mayor Bill de Blasio of New York City said on Thursday that shots would be available for children at city-run vaccination sites within 24 hours after federal clearance, and at locations like doctors’ offices and pharmacies by 48 hours.

“This is a moment parents have been waiting for, to know their kids will be safe,” Mr. de Blasio said at a news conference. “Now, New York City will be ready.”

The city has ordered 231,000 pediatric doses and is working with nearly 1,500 community pediatricians and family doctors to plan vaccination logistics and engage with patients, said Dr. Dave A. Chokshi, the health commissioner.

Much of the rollout of children’s shots is expected to fall on pediatricians and family physicians, who have relationships with patients and children. Many of those physicians, however, are also strained by staffing shortages and a long line of patients trying to book appointments delayed by the pandemic.

Dr. Sterling Ransone Jr., the president of the American Academy of Family Physicians and a physician in rural Deltaville, Va., said that he would keep his office open later on weekdays and on Saturdays to accommodate the demand for pediatric shots.

Some experts have warned, however, that the same inequities that plagued the vaccine rollout for adults earlier this year could hinder the rollout for children.

“We cannot see what we saw in the earliest stages of rolling out the vaccines for adults, in which advantaged persons and persons of means figure out a way to be first in line,” said Dr. James E.K. Hildreth, the president of Meharry Medical College, a historically Black institution.

He said that school nurses, churches and local health officials would be key in reaching some children and families who might not have insurance or access to pediatricians.

Black and Hispanic children are less likely to be tested for the virus but more likely to be infected, get hospitalized and die from Covid-19 than white children are, according to the Kaiser Family Foundation. Hospitalization rates in the 5-to-11 age group are three times as high for Black, Hispanic and Native American children as for white children, according to the C.D.C.

Vaccine hesitancy among all parents is another concern. A survey from the Kaiser Family Foundation released on Thursday found 27 percent of parents of 5- to 11-year-olds were eager to vaccinate their children right away, while a third said they would wait and see how the rollout went.

The uptake among adolescents has been slower than public health experts hoped: Pfizer’s vaccine became available to children 12 to 15 in May, but only roughly 40 percent of that age group is now fully vaccinated, compared to 69 percent of adults.

Daniel E. Slotnik contribued reporting.

Credit…Paul Ellis/Agence France-Presse — Getty Images

LONDON — Health care workers in Britain will visit more than 800 schools beginning Monday to administer Covid vaccines to 12 to 15-year-olds as part of a continuing program to vaccinate the country’s children.

The move comes amid a surge in cases driven primarily by high infection levels in school-age children — more than a third of all recent reported cases were in those under 15 — and as experts warn that the National Health Service could face intense pressure this winter.

More than 600,000 children have received a vaccine since last month, when the vaccination campaign extended to those 12 to 15, the N.H.S. said, adding that health care teams had already visited thousands of schools and inoculated children in the age group after receiving consent from a parent or guardian.

“The vaccines are safe and will help keep children in the classroom,” Sajid Javid, Britain’s health secretary, said in a statement. “I encourage everyone to come forward for their jab to protect themselves and the people around them.”

The effort to vaccinate students will begin as many return from a midsemester break.

Case rates have fallen in recent days, but Britain is reporting an average of 40,700 new daily infections, according to a New York Times database, and deaths have increased by 32 percent in the past two weeks. About 68 percent of the population is fully vaccinated, and more than six million people have received a booster shot.

Britain lifted the bulk of coronavirus restrictions over the summer, though some nations moved more slowly than others. Nightclubs reopened in England in July but only opened in Northern Ireland on Sunday as social distancing restrictions were lifted.

Credit…David Pitt/Associated Press

As Republican governors and attorneys general around the country sue, or threaten to sue, to challenge President Biden’s sweeping vaccine requirements, state legislators of both parties are also taking action on Covid-19 mandates.

Mr. Biden said in September that companies with at least 100 employees must require all their employees to be vaccinated or undergo weekly testing. He also moved to mandate shots for health care workers, federal contractors and the vast majority of federal workers.

The rules have ignited a fierce debate across the country. Republicans insist that it infringes on personal liberty, while Democrats maintain that it is simply sound public health policy.

In a special session, Iowa lawmakers passed a bill late on Thursday in the State Legislature to create exceptions to employer vaccine mandates and to give unemployment benefits to people fired for refusing to be vaccinated.

Minutes before Iowa’s lawmakers were to meet in a special session on redistricting, the assembly released a bill that would allow employers to waive vaccine requirements for religious or health reasons. Crucially, the bill allows Iowans to receive a medical waiver without a doctor’s note.

Gov. Kim Reynolds of Iowa, a Republican who opposes government requirements for masks and vaccines, signed the bill into law on Friday, saying in a statement that “no Iowan should be forced to lose their job or livelihood over the Covid-19 vaccine.” Though Republicans have the majority in the Iowa House and Senate, there was bipartisan support for the bill.

Elsewhere, the Republican-controlled legislature in Tennessee approved a slate of bills early Saturday limiting the enforcement of Covid-19 protections, though lawmakers backed off provisions that would have prevented many businesses in the state from enforcing mask mandates, The Associated Press reported.

The legislation prohibits government entities and public schools, as well as many private businesses, from mandating vaccinations or requiring proof of vaccination, according to the Knoxville News Sentinel. After pushback from the business sector, however, the lawmakers agreed to carve out various industries from the ban on Covid-19 vaccine mandates, including many health care facilities and entertainment venues.

Under the new legislation, government entities will largely be prohibited from implementing mask mandates, unless they meet specific criteria. The changes limits public schools from requiring masks, except in extreme circumstances, according to the education news website Chalkbeat Tennessee.

In Florida, Gov. Ron DeSantis, a Republican who has been a strident opponent of federal vaccine mandates, on Friday called for a special session of the State Legislature in two weeks to consider protections for workers who could lose their jobs because of vaccination requirements, saying in a statement that a person’s “right to earn a living should not be contingent upon Covid shots.”

On Saturday, hundreds rallied outside the Statehouse in Topeka, Kan., expressing opposition to federal Covid-19 mandates as a legislative committee considered recommendations for the Republican-controlled legislative body, The Associated Press reported. The very name of the panel — the Special Committee on Government Overreach and the Impact of Covid-19 Mandates — signaled the political resistance to federally imposed requirements.

By contrast, the Illinois General Assembly, which is controlled by Democrats, raced on the final day of its fall session to make it harder for people to avoid Covid mandates. The legislature updated the state’s “conscience” law that was approved in the 1970s to protect doctors and other health care workers from having to provide abortions that conflict with their beliefs.

The bill, which will be signed into law by Gov. J.B. Pritzker, a Democrat, states that it is not a violation of the law for an employer to take any measures or impose any requirements that help prevent contraction or transmission of Covid-19.

Supporters said that the original 1970s law was never intended to allow residents to use moral or religious objections to avoid vaccination. They said the additional language would close what they argued was a loophole.

Víctor Manuel Ramos contributed reporting.

Credit…Aly Song/Reuters

Shanghai Disneyland will temporarily close and is requiring all visitors to undergo Covid testing on their way out of the park, as part of China’s no-holds-barred campaign to eliminate the virus.

The amusement park will be closed Nov. 1 and 2, with no guarantee of reopening after then, although some hotels within the resort will remain open. The news of the temporary closure on Sunday followed an announcement earlier that day that the park was suspending entries.

The park did not specify the reason for the announcements, except to say that it had received notice from other provinces and cities and was cooperating with their epidemiological investigations. China has raced since mid-October to contain a fresh outbreak tied to domestic tourists, which has so far infected more than 370 people across at least 11 provinces and regions. On Sunday, the National Health Commission reported 48 new locally transmitted cases in the previous 24 hours, though none in Shanghai.

Guests leaving the resort would need to be tested for the coronavirus, followed by another one 24 hours later, the park’s announcement said. They would then need to self-monitor for 12 days.

Images on social media showed large groups of workers in full personal protective equipment circulating throughout the park, and long lines of visitors waiting to leave.

A spokesman for the National Health Commission had said on Saturday that the latest outbreak was “still developing rapidly” and that the situation was “severe and complicated.” The newest round of infections, though small compared to outbreaks in many other countries, is relatively large for China, which has officially reported just about 97,000 cases since the start of the pandemic.

On the Chinese social media platform Weibo, where the news of the suspension was trending, some commenters whweo said they had already bought tickets expressed disappointment. But many comments expressed support for the measure and concern about photos of crowds at the park during the Halloween weekend. China’s commitment to a “zero Covid” policy — which has made it an outlier globally — has widespread support domestically, as it has allowed relatively restriction-free travel within the country.

Still, some experts have warned that the economic toll of repeated lockdowns and other strict prevention measures may eventually become too heavy. Throughout the pandemic, domestic tourism and consumption have suffered when new outbreaks are reported, as people seek to avoid becoming trapped in high-risk areas.

Claire Fu contributed research

Credit…David Dee Delgado/Getty Images

New York City’s sweeping effort to compel most city employees to receive the coronavirus vaccine before Monday appears to have rapidly boosted inoculation rates and pressured thousands of police officers, firefighters and other government workers who had long held out to get the shot.

The vaccination rate among workers affected by the city’s mandate rose to 83 percent at the end of Friday, from 71 percent on Oct. 19, the day before the requirement was announced, according to city data. Some individual agencies reported jumps in vaccination rates of nearly 10 percentage points between Thursday and Friday alone.

The last-minute rush in the nation’s largest municipal work force mirrored similar patterns involving other vaccine mandates. Thousands of health care workers around the state rushed to get their first doses in the days before a requirement for employees at hospitals and nursing homes took effect last month.

Still, more than 25,000 city workers affected by the mandate remain unvaccinated and will be placed on unpaid leave on Monday if they do not receive the shot over the weekend. And speculation was fueled in recent days that some employees in agencies including the Sanitation and Fire Departments had already begun to slow down work in protest of the mandate.

New Yorkers across several boroughs, for example, have reported garbage pileups and significant delays in trash pickups in their neighborhoods.

Sanitation officials say the most severe delays have been seen across Staten Island and in parts of southern Brooklyn, including the Bay Ridge and Bensonhurst areas. Data shows that overall 311 complaints soared last week with more than 1,000 reports of uncollected trash and recycling on some days, as the local news outlet Gothamist reported. (The number had hovered between 100 and 250 through the rest of October.)

Mayor Bill de Blasio said this week that he believes some of the delays may be attributed to declines from workers in protest of the vaccination requirement.

“I’m assuming it is related to people expressing their views on this new mandate,” Mr. de Blasio said at a recent news conference. “You want a protest, go protest. But when you’re on the clock, you have to do your job.”

Similar problems were reported among some workers in other agencies as the vaccination deadline approached.

Fire officials said that an uptick in sick calls among employees toward the end of the week was responsible for the temporary closures of several fire stations across the Bronx and other boroughs.

“The excessive sick leave by a group of our firefighters because of their anger at the vaccine mandate for all city employees is unacceptable, contrary to their oaths to serve and may endanger the lives of New Yorkers,” the fire commissioner, Daniel A. Nigro, said in a statement.

Union leaders for both fire and sanitation workers denied reports of the changes in work patterns.

Still, the overall rise in the vaccination rate for municipal workers offered a measure of optimism that significant disruptions to government agencies and city life could be avoided as enforcement of the mandate begins on Monday.

Before the requirement was announced on Oct. 20, and an option to opt into weekly testing was removed, only about 60 percent of employees in the Fire and Sanitation Departments had received at least one vaccine dose. The Police Department’s rate sat around 70 percent.

Holdout workers were offered $500 as a bonus if they got vaccinated by the end of the workday on Friday. By that deadline, more than 75 percent of fire and sanitation workers had been vaccinated — along with nearly 85 percent of the Police Department’s 36,000 uniformed and 15,000 civilian employees.

Joseph Goldstein contributed reporting.

Credit…Pavel Golovkin/Associated Press

President Xi Jinping of China and President Vladimir V. Putin of Russia on Saturday called for “mutual recognition” of Covid-19 vaccines by global health authorities.

Both leaders delivered the remarks by video to the Group of 20 summit in Rome after deciding not to attend the meeting in person.

Mr. Putin said global access to Covid vaccines was suffering “in part because of protectionism, because of inability and unwillingness by some countries to recognize and register vaccines,” according to a video posted online by RT, a state-controlled Russian TV network.

A Russian vaccine, Sputnik V, has been authorized by 70 countries, Mr. Putin said. But it has not been authorized by the European Union’s main drug regulator, the European Medicines Agency, or the World Health Organization. Markus Ederer, the European Union’s ambassador to Russia, said this month that the Russian authorities had delayed inspections.

“The Russian side has repeatedly postponed the timing of the inspection requested by the E.M.A., which slows down the process,” Markus Ederer told the local outlet RBC. “These are the facts.”

Mr. Putin called on the W.H.O. to expedite the vaccine registration process. “As soon as this is done,” he said, “we will be able to restore and restart the economy.” He said he would also like the Group of 20 to “address the problem of mutual recognition of vaccine certificates.”

Over the summer, many countries opened to international travel, but the patchwork of rules regarding which vaccines would be accepted led to confusion and frustration for travelers, especially those who had received vaccines that were not widely accepted.

Two vaccines made by China, Sinopharm and Sinovac, are on the W.H.O.’s emergency authorization list. Across Asia and South America, millions of people have received doses of those vaccines, and millions more have received doses of vaccines, like Sputnik V, that have been authorized by individual governments only.

On Saturday, Mr. Xi said China had provided more than 1.6 billion shots to the world and was working with 16 countries on manufacturing vaccines, according to a transcript published by the official Xinhua news agency, Reuters reported.

Mr. Xi expressed support for a World Trade Organization decision that waived intellectual property rights for Covid-19 vaccines, Reuters said, and he called for vaccine manufacturers to transfer technology to developing countries.

Credit…Merck

Britain, Australia and South Korea have reached agreements with the drugmaker Pfizer to purchase its antiviral pills used to treat Covid-19 once regulators approve them, the company said on Friday.

Under the terms of the agreements, Australia will buy 500,000 courses of Pfizer’s pill, known as PF-07321332, and Britain will purchase 250,000, the company said. Earlier this month, Australia secured 300,000 courses of another antiviral pill, molnupiravir, made by the drug manufacturer Merck, and Britain agreed to buy 480,000.

South Korea secured 70,000 courses of Pfizer’s pill, the health ministry said in a statement on Friday. It has also signed a purchase agreement with Merck for 200,000 courses of its pill.

The United States has not yet agreed to buy Pfizer’s pills, a spokeswoman for the company, Roma Nair, said by telephone on Friday. The United States has reached a deal with Merck to buy 1.7 million courses of molnupiravir.

Merck’s and Pfizer’s pills could be a milestone in the fight against the coronavirus because they do not require a visit to the hospital and are relatively inexpensive, unlike the antibody treatments currently being used.

Both pills are designed to interfere with viral replication. If approved by regulators, both pills could be prescribed at the first sign of infection or exposure without requiring hospitalization.

Merck has already reported data from its Phase 3 trials that showed molnupiravir reduced the risk of hospitalization or death by half. Merck has submitted an application to the U.S. Food and Drug Administration to authorize its pill. European Union regulators said on Monday that they had begun a review of molnupiravir.

Meanwhile, Pfizer said in a statement that it had begun Phase 2/3 trials to evaluate the efficacy and safety of its pill.

France has ordered 50,000 courses of Merck’s pills to be delivered starting in the end of November, the health minister, Olivier Véran, said on Tuesday.

The Philippines said this week that it had procured 300,000 courses of molnupiravir. Malaysia and Singapore have also secured supplies of Merck’s pills.

South Korea’s health ministry said it planned to purchase enough antiviral pills for 404,000 patients in total, and to have supplies available starting in the first quarter of 2022. It said it would closely monitor the progress of clinical trials for pills under development at several companies, including Merck, Pfizer and Roche, as it considers its options.



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Man allegedly punched nurse for vaccinating wife without his consent

A Canadian man allegedly punched a nurse in the face after the medical professional gave his wife a COVID-19 vaccine without his consent, according to local officials.

The man allegedly confronted the nurse in a pharmacy in the city of Sherbrooke, which is about 100 miles southeast of Montreal in Quebec where she had been sent to administer vaccines.

“Our suspect went directly into the office and began to yell at the nurse,” police spokesman Martin Carrier told Reuters in a phone interview.

The man became outraged upon learning that his wife was vaccinated at the office “without his authorization” and hit her in the face, Carrier said.

It is unclear whether the suspect opposed vaccinations or whether his wife had been vaccinated at that pharmacy, Carrier told Reuters.

Canadian President Justin Trudeau has criticized anti-vaccine protests occurring throughout the country while campaigning for reelection. Protests have increased last week ahead of the federal election.

Quebec Premier François Legault said Wednesday he hoped to pass a law this week to stop anti-vaxxers from protesting near schools and hospitals or face a fine.

“My patience has reached its limit,” he told reporters in Quebec City. “I think it’s important to leave our children and patients in peace.”

With wires

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The countries that are vaccinating children against Covid-19

Data from earlier in the pandemic showed that children are less likely to become seriously ill. The emergence of Delta has been a game changer, however, destroying the myth that healthy kids can’t get hit hard by the virus.

While many high-income nations, including the United States and most members of the European Union, now offer Covid vaccines for children 12 and older, a handful of countries have now authorized the shot for younger people. Meanwhile, severe vaccine inequality persists on a global level, with many developing nations continuing to struggle to provide first and second doses to high-risk groups — with the very idea of getting shots to children still a pipe dream.

Here’s a global snapshot of where things stand.

Cuba became the first country in the world to vaccinate children as young as 2 this month, with the government saying that its homegrown vaccines are safe for younger kids. The island nation initially planned to focus on vaccinating healthcare workers, the elderly and the hardest-hit areas. Then, following a spike in infections among children attributable to Delta, it announced that it would also prioritize young children in a bid to safely reopen classrooms.

Throughout the pandemic, most in-person classes have been suspended in Cuba. Students have been primarily learning through educational television programming instead, as home internet remains a rarity on the island.

Cuba has yet to provide data on its vaccines to outside observers, but has said it will seek World Health Organization (WHO) approval on Thursday.

Chile, China, El Salvador and the United Arab Emirates have also approved vaccines for younger children. In Chile, children aged 6 and older can get the Sinovac shot, while in China, the Sinovac and CoronaVac vaccines are authorized for use in children as young as 3. In El Salvador, children as young as 6 will soon be able to get vaccinated, while in the United Arab Emirates — where Sinopharm is approved for 3-year-olds — the government has made it clear that the vaccination program will be optional.

Meanwhile, American children between 5 and 11 could be eligible for the vaccine sometime this fall, pending approval from the US Food and Drug Administration. Pfizer’s CEO said Tuesday that the company plans to submit data on its vaccine from studies involving that age group by the end of this month.

Where governments are still weighing up what to do regarding younger children

The United Kingdom has been more cautious than many other European countries in regard to vaccinating younger populations, only recommending the shot for 12-15 year olds on Monday, following advice from its chief medical officers. The move ended months of debate among scientists and government, and places it in line with the US and many other European countries that have been vaccinating this age group for months.

In late May, the European Medicines Agency (EMA) approved the use of Pfizer/BioNtech’s vaccine for children aged 12-15, based on a trial that showed that the immune response to the vaccine in that age group was comparable to the immune response seen in people from 16-25. The EMA approved the Moderna vaccine for 12-15 year olds in late July.

France, Denmark, Germany, Ireland, Italy, Spain and Poland are among EU countries that have rolled out their vaccination campaigns for 12-15 year olds, with uptake varying across the bloc.

Switzerland — which is not part of the EU — has been vaccinating the younger age group since June. Sweden will offer the vaccine to 12-15 year-olds later in the fall, Sweden’s Prime Minister Stefan Lofven said Thursday.

Meanwhile, in the UK there are no current plans to vaccinate children under 12, according to Chris Whitty, England’s chief medical officer.

The UK’s current guidelines for 12-15-year-olds were put forward in the hope that they will reduce the spread of the virus in schools, Whitty said. He noted, however, that vaccinations aren’t a silver bullet and that policies to minimize transmission should remain in place. Teenagers will get just one dose of the vaccine for now.

The new guidance has also reinvigorated a debate on consent in the UK, especially when a parent and child disagree. While parents in Britain generally need to authorize vaccination for children under 16, children can overrule vaccine-hesitant parents if a clinician considers them “competent” to do so.

Where vaccinating under-12s is not an option because there aren’t enough doses

While more than 42% of the global population has had at least one dose of the vaccine, only 1.9% of people in low-income countries have received at least one shot, continuing to leave billions at high risk of disease and death when exposed to Covid-19.

Haiti only received its first vaccines in July, with the delivery of 500,000 doses donated by the US through the COVAX vaccine-sharing program. Fewer than 1% of the country’s 11.4 million people — of whom nearly a third are under the age of 14 — have been vaccinated so far.

In May, when some high-income countries began vaccinating children and other low-risk groups, World Health Organization chief Tedros Adhanom Ghebreyesus said they were “doing so at the expense of health workers and high-risk groups in other countries.”

Where vaccinations for children could be more difficult to roll out

While no countries appear to have categorically ruled out inoculating younger children so far, vaccine hesitancy among policy makers could play a part in countries apparently uncertain about doing so.

In the Democratic Republic of Congo, just over 120,000 doses have been administered — leaving under 0.1% of the country’s population of 90 million protected. Last week, the country received 250,000 doses of the Moderna vaccine, donated by the US through COVAX. Another 250,000 Pfizer doses are to follow shortly.

However, vaccine skepticism remains high in the country, with prominent leaders, including the president, contributing to that hesitancy.

In March more than 1.7 million AstraZeneca doses arrived in Kinshasa, but the government delayed its rollout after reports of rare blood clots and then exported about 75% of the shipment.

On Monday, after waiting for six months, DRC President Félix Tshisekedi got vaccinated, saying after his first dose of the Moderna shot that “by this act I want to show my compatriots that it is really necessary to take the vaccine and that it is not necessary to worry.” He added that his wife had also taken the vaccine, and then urged others to do so, “because it saves lives.”

The change in messaging might leave public health officials hopeful for getting more shots in arms in the months ahead. But how that will play out in terms of vaccinating children remains unclear in a country where misinformation on vaccines runs rife and where, earlier this year, around 70% of healthcare workers said they would not get the shot.

CNN’s Patrick Oppmann, Larry Madowo, Jack Guy and Niamh Kennedy contributed to this report.

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