Konami Digital Entertainment [994 articles]” href=”https://www.gematsu.com/companies/konami”>Konami launched the YouTube page (English, Japanese) for today’s Silent Hill Transmission broadcast earlier this morning, which will premiere at 2:00 p.m. PT / 5:00 p.m. ET, accidently including information about what it will be showing—both in plain sight in the video description and hidden in its video tags.
The video description listed “Silent Hill 2” with a placeholder bullet point for a PlayStation [41,153 articles]” href=”https://www.gematsu.com/platforms/playstation”>PlayStation Store pre-order link:
The video tags, which are accessible by viewing the page source on any browser, are as follows:
And here they are in an easy-to-read bullet list:
Ascension
Interview
KONAMI
PlayStation
Return to SILENT HILL
SILENT HILL
SILENT HILL 2
SILENT HILL Transmission
SILENT HILL f
SILENT HILL: Ascension
Steam
Teaser Trailer
While both the mention of Silent Hill 2 in the video description and all video tags have since been removed, they can still be seen in archived versions of the YouTube page (English, Japanese). (For the video tags, view the page source of the archived page.)
Since the premature death of Silent Hills and the P.T. demo, we’ve seen a constant stream of supposed leaks and rumors about what will be the next Silent Hill game. Plenty of people claim to have inside information, but this Wednesday, we’ll hear it directly from the people who actually run the show. Konami dropped word on Sunday that a Silent Hill Transmission will broadcast on October 19 and will feature “the latest updates for the Silent Hill series.”
In your restless dreams, do you see that town?
The latest updates for the SILENT HILL series, will be revealed during the #SILENTHILL Transmission on Wednesday, October 19th, at 2:00 PM. PDThttps://t.co/18sulbhIaR
— Konami (@Konami) October 16, 2022
It’s anybody’s guess what we’ll see in the show, but I’d put my money on Konami pulling back the curtain on that recently uncovered Silent Hill: The Short Message product listing. Could The Short Message be a new game or a remake of one of the previous games in the series? Is it that Abandoned game we’ve all stopped making fun of? I used the Silent Hill: Shattered Memories key art in the banner image because Sam Barlow mentioned a follow-up to that masterpiece in the past. And Masahiro Ito seems to be aware of it. I guess as long as Konami isn’t revealing a new pachinko machine, it should be worth tuning in for.
The Silent Hill franchise has been in purgatory for about a decade following the release of Downpour and Book of Memories in 2012. Hideo Kojima famously tried to take the reigns of the franchise in 2014 with Silent Hills, but following a well-publicized fallout with Konami, he left the company and the project behind to form his own studio. There have been many rumors of Kojima creating a Silent Hill game over at Kojima Productions, but there’s not been anything concrete on that front.
Whatever it is, fans won’t have to wait long. The Silent Hill Transmission is set for October 19 at 2:00 pm Pacific.
CJ Andriessen
Just what the internet needs: yet another white guy writing about video games.
Konami has launched a new Silent Hill website with a date fans of the horror franchise will want to mark their calendars for – October 19, 2022, at 2pm PT/5pm ET/10pm BST.
The website was announced alongside a tweet that says, “In your restless dreams, do you see that town? The latest updates for the SILENT HILL series, will be revealed during the #SILENTHILL Transmission on Wednesday, October 19th, at 2:00 pm. PDT.”
In your restless dreams, do you see that town?
The latest updates for the SILENT HILL series, will be revealed during the #SILENTHILL Transmission on Wednesday, October 19th, at 2:00 PM. PDThttps://t.co/8Knoq9xYsa
— Silent Hill Official (@SilentHill) October 16, 2022
While it’s not 100% a confirmation, Masahiro Ito, who has played a huge role in Silent Hill’s past and was the art director of such games as Silent Hill 2, may be involved in the series’ future as he retweeted the announcement.
Silent Hill has been quiet for some time, but rumors and reports have been circling that a comeback may be in order. Most recently, Silent Hill movie director Christophe Gans said that “multiple” games in the franchise are in development.
This tease joins an unannounced Silent Hill game called The Short Message getting rated in South Korea, leaked images of a project in the series, and a rumor that Bloober Team is working on a remake of Silent Hill 2.
Have a tip for us? Want to discuss a possible story? Please send an email to newstips@ign.com.
Adam Bankhurst is a news writer for IGN. You can follow him on Twitter @AdamBankhurst and on Twitch.
Summary: By altering the epigenetic markers on chromosomes, researchers witnessed changed gene expression in offspring and grand-offspring. The findings reveal the occurrence of transgenerational epigenetic inheritance.
Source: UC Santa Cruz
Without altering the genetic code in the DNA, epigenetic modifications can change how genes are expressed, affecting an organism’s health and development. The once radical idea that such changes in gene expression can be inherited now has a growing body of evidence behind it, but the mechanisms involved remain poorly understood.
A new study by researchers at UC Santa Cruz shows how a common type of epigenetic modification can be transmitted via sperm not only from parents to offspring, but to the next generation (“grandoffspring”) as well.
This is called “transgenerational epigenetic inheritance,” and it may explain how a person’s health and development could be influenced by the experiences of his or her parents and grandparents.
The study, published the week of September 26 in the Proceedings of the National Academy of Sciences (PNAS), focused on a particular modification of a histone protein that changes the way DNA is packaged in the chromosomes.
This widely studied epigenetic mark (called H3K27me3) is known to turn off or “repress” the affected genes and is found in all multicellular animals—from humans to the nematode worm C. elegans used in this study.
“These results establish a cause-and-effect relationship between sperm-transmitted histone marks and gene expression and development in offspring and grandoffspring,” said corresponding author Susan Strome, professor emerita of molecular, cell and developmental biology at UC Santa Cruz.
Histones are the main proteins involved in the packaging of DNA in the chromosomes. The epigenetic mark known as H3K27me3 refers to methylation of a particular amino acid in the histone H3. This leads to the DNA being more densely packaged, making the genes in that region less accessible for activation.
The new study involved selectively stripping this histone mark from the chromosomes of C. elegans sperm, which were then used to fertilize eggs with fully marked chromosomes.
In the resulting offspring, the researchers observed abnormal gene expression patterns, with genes on the paternal chromosomes (inherited from the sperm) turned on or “upregulated” in the absence of the repressive epigenetic mark.
This led to tissues turning on genes they would not normally express. For example, germline tissue (which produces eggs and sperm) turned on genes normally expressed in neurons.
“In all the tissues we analyzed, genes were aberrantly expressed, but different genes were turned up in different tissues, demonstrating that the tissue context determined which genes were upregulated,” Strome said.
Analysis of the chromosomes in the offspring’s germline tissue revealed that the upregulated genes still lacked the repressive histone mark, while the mark had been restored on the genes that were not upregulated.
“In the germline of the offspring, some genes were aberrantly turned on and stayed in the state lacking the repressive mark, while the rest of the genome regained the mark, and that pattern was passed on to the grandoffspring,” Strome explained.
“We speculate that if this pattern of DNA packaging is maintained in the germline, it could potentially be passed on for numerous generations.”
In a study of epigenetic inheritance, researchers created embryos of the worm C. elegans that inherited egg chromosomes properly packaged with the epigenetic mark H3K27me3 and sperm chromosomes lacking the mark. The one-cell embryo on the left inherited the pink chromosomes from the egg and the green chromosomes from the sperm, the colors showing the presence or absence of H3K27me3. The two-cell embryo on the right shows the egg and sperm chromosomes united in each nucleus. Credit: Laura Gaydos
In the grandoffspring, the researchers observed a range of developmental effects, including some worms that were completely sterile. This mix of outcomes is due to how chromosomes get distributed during the cell divisions that produce sperm and eggs, resulting in many different combinations of chromosomes that can be passed on to the next generation.
Researchers in Strome’s lab have been studying epigenetic inheritance in C. elegans for years, and she said this paper represents the culmination of their work in this area. She noted that other researchers studying mammalian cells in culture have reported results very similar to her lab’s findings in worms, although those studies did not show transmission across multiple generations.
“This looks like a conserved feature of gene expression and development in animals, not just a weird worm-specific phenomenon,” she said. “We can do amazing genetic experiments in C. elegans that can’t be done in humans, and the results of our experiments in worms can have broad implications in other organisms.”
The co-first authors of the paper are Kiyomi Kaneshiro, who worked on the study as a graduate student in Strome’s lab and is currently a postdoctoral researcher at the Buck Institute for Research on Aging, and UCSC research associate Thea Egelhofer.
The coauthors also include bioinformaticist Andreas Rechtsteiner and graduate student Chad Cockrum (now at IDEXX Laboratories).
See also
Funding: This work was supported by the National Institutes of Health.
About this epigenetics research news
Author: Tim Stephens Source: UC Santa Cruz Contact: Tim Stephens – UC Santa Cruz Image: The image is credited to Laura Gaydos
Original Research: Closed access. “Sperm-inherited H3K27me3 epialleles are transmitted transgenerationally in cis” by Susan Strome et al. PNAS
Abstract
Sperm-inherited H3K27me3 epialleles are transmitted transgenerationally in cis
The transmission of chromatin states from parent cells to daughter cells preserves cell-specific transcriptional states and thus cell identity through cell division. The mechanism that underpins this process is not fully understood.
The role that chromatin states serve in transmitting gene expression information across generations via sperm and oocytes is even less understood. Here, we utilized a model in which Caenorhabditis elegans sperm and oocyte alleles were inherited in different states of the repressive mark H3K27me3.
This resulted in the alleles achieving different transcriptional states within the nuclei of offspring.
Using this model, we showed that sperm alleles inherited without H3K27me3 were sensitive to up-regulation in offspring somatic and germline tissues, and tissue context determined which genes were up-regulated.
We found that the subset of sperm alleles that were up-regulated in offspring germlines retained the H3K27me3(−) state and were transmitted to grandoffspring as H3K27me3(−) and up-regulated epialleles, demonstrating that H3K27me3 can serve as a transgenerational epigenetic carrier in C. elegans.
New Jersey on Tuesday reported another 1,474 confirmed COVID-19 cases and 12 confirmed deaths a day after the state’s rate of transmission rose above a key benchmark.
The rate of transmission was 1.04, up from 0.97 on Sunday.
When the transmission rate is 1, that means cases have leveled off at the current numbers, while anything above 1 indicates the outbreak is expanding.
The state’s seven-day average for confirmed coronavirus positive tests is 1,433, a 2% increase from a week ago and a 22% decrease from a month ago.
The U.S. Centers for Disease Control and Prevention deems 11 counties in the state to have “medium” community levels of transmission: Sussex, Warren, Hunterdon, Monmouth, Ocean, Burlington, Atlantic, Camden, Gloucester, Salem, and Cape May.
The remaining 10 counties — Bergen, Passaic, Hudson, Morris, Essex, Union, Middlesex, Somerset, Mercer and Cumberland — are deemed “low,” according to the CDC.
There were 861 patients with confirmed or suspected coronavirus cases reported at the state’s 71 hospitals as of Tuesday. Of those hospitalized, 101 are in intensive care and 30 are on ventilators.
The statewide positivity rate for tests conducted Thursday, the most recent day for which data is available, was 10.61%.
The CDC considers positivity rates above 10% to be “high.” The positivity rate is substantially lower than its peak of 40.83% on Jan. 1 during the height of the omicron variant.
TOTAL NUMBERS
New Jersey has reported 2.3 million total confirmed COVID-19 cases since the state reported its first known case March 4, 2020.
The Garden State has also recorded 410,130 positive antigen or rapid tests, which are considered probable cases. There are also numerous cases that likely never have been counted, including at-home positive tests that are not included in the state’s numbers.
The state of 9.2 million residents has reported 34,689 COVID-19 deaths — 31,577 confirmed fatalities and 3,112 probable ones.
New Jersey has the ninth-most coronavirus deaths per capita in the U.S. — behind Mississippi, Arizona, Oklahoma, Alabama, West Virginia, New Mexico, Tennessee and Arkansas — as of the latest data reported on Sept. 12. Last summer, the state had the most deaths per capita in the nation.
VACCINATION NUMBERS
More than 7.05 million people who work, live or study in the Garden State have reached fully vaccinated status. More than 7.92 million have received a first dose since vaccinations began in the state on Dec. 15, 2020.
More than 4.27 million people in the state eligible for boosters have received one.
LONG-TERM CARE NUMBERS
At least 9,662 of the state’s COVID-19 deaths have been among residents and staff members at nursing homes and other long-term care facilities, according to the most recent data.
Of the active outbreaks at 370 facilities, there are 7,100 current cases among residents and 6,889 cases among staff, as of the latest data.
GLOBAL NUMBERS
There have been more than 612 million COVID-19 cases reported across the globe as of Tuesday, according to Johns Hopkins University’s coronavirus database. More than 6.5 million people have died because of the virus, the data shows.
The U.S. has reported the most cumulative cases (more than 95.7 million) and deaths (at least 1.05 million) of any nation.
There have been more than 12.2 billion vaccine doses administered globally.
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Camille Furst may be reached at cfurst@njadvancemedia.com. Find her on Twitter @CamilleFurst.
The men, who live together and are in a non-exclusive relationship, were diagnosed with monkeypox at a hospital in Paris in early June. Twelve days after their symptoms started, their 4-year-old Italian greyhound also started showing symptoms, according to a report published last week in the journal The Lancet.
The dog developed lesions and tested positive for the same type of monkeypox as one of the owners.
According to the report, the men said that they let their dog sleep in bed with them and that they had been careful to keep their pet away from other animals or humans from the start of their own symptoms — before the dog’s symptoms started.
“To the best of our knowledge, the kinetics of symptom onset in both patients and, subsequently, in their dog, suggest human-to-dog transmission of monkeypox virus,” the authors of the report wrote. “Given the dog’s skin and mucosal lesions as well as the positive monkeypox virus PCR results from anal and oral swabs, we hypothesise a real canine disease, not a simple carriage of the virus by close contact with humans or airborne transmission (or both).”
The authors suggested that the study should prompt discussion on whether pets need to be isolated from their owners if they have monkeypox, and they called for further research.
New, but not surprising, information, WHO says
Lewis said that previously, only animal-to-human transmission of the virus was reported, referencing a monkeypox outbreak in the US in which people were infected with the virus through pet prairie dogs.
“This is the first incident that we’re learning about where there is human-to-animal transmission,” Lewis said during a Washington Post Live event on Monday. “This has not been reported before, and it has not been reported that dogs have been infected before.
“On a number of levels, this is new information,” she said. “It’s not surprising information, and it’s something that we’ve been on the watch out for.”
She noted that within WHO, experts have been working with partners such as the World Organization of Animal Health and the Food and Agriculture Organization to address the issue.
“The messaging that has been given up until now is that pets should be isolated from the family members who may be infected,” she said. “This has been an example of precautionary approach, precautionary messaging, because we didn’t have the information that this had ever happened before, it had not been reported before, but it was a reasonable, cautious message to give. And now we have the first incident where this has actually occurred.”
Lewis said it isn’t clear whether the infected dog will be able to transmit the virus back to humans. But sometimes, even when they don’t have all the evidence, public health profesionals have to figure out the most useful messaging that will allow people to appreciate their level of risk.
“This is an example where most pets will not be at risk, it may only be those who are actually in the household of someone who’s infected,” she said.
CDC says infected people should stay away from animals
The US Centers for Disease Control and Prevention recently updated its page on monkeypox in animals to acknowledge that dogs can be infected with the virus.
“We are still learning which species of animals can get monkeypox,” the agency said. “While we do not know if reptiles, amphibians, or birds can get monkeypox, it is unlikely since these animals have not been found to be infected with other orthopoxviruses.”
The CDC also notes that infected animals can spread the virus to people, and it is “possible that people who are infected can spread Monkeypox virus to animals through close contact, including petting, cuddling, hugging, kissing, licking, sharing sleeping areas, and sharing food.”
The agency advises people with monkeypox to avoid contact with animals, including their pets.
Pets who had close contact with someone with monkeypox symptoms should be kept at home and away from other animals and people for 21 days after the most recent contact, the CDC said. Infected people shouldn’t get close to their exposed pet; they should ask someone else within the home to look after it if possible.
If the infected person and the pet did not have close contact after symptoms started, the CDC recommends asking someone who lives elsewhere to look after the animal until there is a full recovery from the virus.
The men, who live together and are in a non-exclusive relationship, were diagnosed with monkeypox at a hospital in Paris in early June. Twelve days after their symptoms started, their 4-year-old Italian greyhound also started showing symptoms, according to a report published last week in the journal The Lancet.
The dog developed lesions and tested positive for the same type of monkeypox as one of the owners.
According to the report, the men said that they let their dog sleep in bed with them and that they had been careful to keep their pet away from other animals or humans from the start of their own symptoms — before the dog’s symptoms started.
“To the best of our knowledge, the kinetics of symptom onset in both patients and, subsequently, in their dog, suggest human-to-dog transmission of monkeypox virus,” the authors of the report wrote. “Given the dog’s skin and mucosal lesions as well as the positive monkeypox virus PCR results from anal and oral swabs, we hypothesise a real canine disease, not a simple carriage of the virus by close contact with humans or airborne transmission (or both).”
The authors suggested that the study should prompt discussion on whether pets need to be isolated from their owners if they have monkeypox, and they called for further research.
New, but not surprising, information, WHO says
Lewis said that previously, only animal-to-human transmission of the virus was reported, referencing a monkeypox outbreak in the US in which people were infected with the virus through pet prairie dogs.
“This is the first incident that we’re learning about where there is human-to-animal transmission,” Lewis said during a Washington Post Live event on Monday. “This has not been reported before, and it has not been reported that dogs have been infected before.
“On a number of levels, this is new information,” she said. “It’s not surprising information, and it’s something that we’ve been on the watch out for.”
She noted that within WHO, experts have been working with partners such as the World Organization of Animal Health and the Food and Agriculture Organization to address the issue.
“The messaging that has been given up until now is that pets should be isolated from the family members who may be infected,” she said. “This has been an example of precautionary approach, precautionary messaging, because we didn’t have the information that this had ever happened before, it had not been reported before, but it was a reasonable, cautious message to give. And now we have the first incident where this has actually occurred.”
Lewis said it isn’t clear whether the infected dog will be able to transmit the virus back to humans. But sometimes, even when they don’t have all the evidence, public health profesionals have to figure out the most useful messaging that will allow people to appreciate their level of risk.
“This is an example where most pets will not be at risk, it may only be those who are actually in the household of someone who’s infected,” she said.
CDC says infected people should stay away from animals
The US Centers for Disease Control and Prevention recently updated its page on monkeypox in animals to acknowledge that dogs can be infected with the virus.
“We are still learning which species of animals can get monkeypox,” the agency said. “While we do not know if reptiles, amphibians, or birds can get monkeypox, it is unlikely since these animals have not been found to be infected with other orthopoxviruses.”
The CDC also notes that infected animals can spread the virus to people, and it is “possible that people who are infected can spread Monkeypox virus to animals through close contact, including petting, cuddling, hugging, kissing, licking, sharing sleeping areas, and sharing food.”
The agency advises people with monkeypox to avoid contact with animals, including their pets.
Pets who had close contact with someone with monkeypox symptoms should be kept at home and away from other animals and people for 21 days after the most recent contact, the CDC said. Infected people shouldn’t get close to their exposed pet; they should ask someone else within the home to look after it if possible.
If the infected person and the pet did not have close contact after symptoms started, the CDC recommends asking someone who lives elsewhere to look after the animal until there is a full recovery from the virus.
A medical journal has published evidence of the first suspected case of human-to-pet transmission of the monkeypox virus.
A dog living with two men in France who were infected with the virus began exhibiting symptoms 12 days after they did, according to The Lancet. The 4-year-old male Italian greyhound, which had no previous medical disorders, tested positive after showing symptoms such as lesions and pustules on its abdomen.
Through DNA testing, researchers determined the viruses infecting the two men and the dog were both monkeypox.
Since they became symptomatic, the two men had kept their dog away from other people and other pets but had slept with the animal in their bed.
“Our findings should prompt debate on the need to isolate pets from monkeypox virus-positive individuals,” the report reads.
The Centers for Disease Control and Prevention (CDC) has warned against possible human-to-pet transmission in its monkeypox guidance.
“Infected animals can spread Monkeypox virus to people, and it is possible that people who are infected can spread Monkeypox virus to animals through close contact,” the guidance reads.
Those who are infected are advised to avoid activities with their pets, including petting, cuddling, hugging, kissing, licking, sharing sleeping areas and sharing food.
While the full symptoms of monkeypox in pets are unknown, watch for “potential signs of illness including lethargy, lack of appetite, coughing, nasal secretions or crust, bloating, fever, and/or pimple- or blister-like skin rash,” the CDC warns.
BOISE (Idaho Capital Sun) — A person in Canyon County appears to have caught the monkeypox virus, in what would be Idaho’s first identified case of local transmission.
The Southwest District Health public health department reported the case Friday in a news release.
“The investigation is ongoing. Local and state public health officials are working with the patient’s healthcare providers to ensure the patient is treated and any potential close contacts are identified and notified of exposure risk,” the department said.
A spokesperson for the department told the Idaho Capital Sun, “Currently, no travel has been identified at this time in the investigation.”
The department also reminded the public that most people recover at home after a mild illness. There are antiviral medications available, but public health officials encourage vaccination for people who have been exposed to monkeypox. “Individuals with monkeypox should self-isolate until their lesions have fully healed with new skin where the lesions used to be,” it said.
The Centers for Disease Control and Prevention on Friday reported more than 4,900 cases of the monkeypox virus in the U.S. Three of those cases were in Idaho.
State and local health officials on July 6 announced the first probable case of monkeypox in Idaho, in a person living in the Central District Health region. The patient was believed to have caught monkeypox during travel to another country. At the time, there were more than 560 known cases of monkeypox in the U.S.
There are many differences between the monkeypox virus and the coronavirus responsible for COVID-19. Still, observers have noted some parallels between the early outbreaks of both infectious diseases. For instance, monkeypox testing has been limited, and it is unclear how many cases are going undetected, allowing for more transmission. However, the smallpox vaccine is effective against monkeypox, so immunizations do not need to be developed from scratch.
Members of Congress have been slow to react to the growing monkeypox outbreak, States Newsroom reported Thursday.
“Public health officials in the Biden administration have held several briefings, expanded testing capacity to nationwide commercial laboratories, distributed more than 200,000 vaccine doses and begun ordering millions more for the national stockpile,” according to States Newsroom reporting.
SANTA ANA, Calif. (KABC) — Orange County health experts are once again keeping a close eye on COVID-19 cases as the county moves to “high” community transmission.
“Right now we’re certainly seeing a surge in cases,” said Dr. Matt Zahn, deputy health officer for the Orange County Healthcare Agency.
He said transmission in the community is up due to the highly transmissible omicron subvariants.
“We have such an overlap in terms of our populations from Los Angeles County and us and other surrounding counties,” Zahn said. “It’s fair to say we’re all seeing this increase in cases. We’re all in this together.”
According to the Centers for Disease Control and Prevention’s COVID-19 data tracker, Los Angeles County’s COVID-19 community level is now in the “high” category.
Ventura and Orange counties also moved into the “high” level this week based on elevated rates of people being infected with the virus.
San Bernardino and Riverside counties are currently in the “medium” category.
“Whenever we’ve seen an increase like this in the past during the pandemic there usually was an increase in ICU cases and also deaths. We’re not seeing that,” said Jose Arballo, public information officer for the Riverside County Department of Health.
If L.A. County stays at the “high” category for two weeks straight, officials say it would trigger a new indoor mask mandate.
It’s a move residents in some neighboring counties should not expect to see.
“We’ve always followed the state guidelines and mandates,” Arballo said. “I believe we will continue to do so. That’s the instruction we’ve been given.”
“In Orange County, we are not moving toward mandates at this point,” Zahn said.
Right now, health officials said anyone who feels safer wearing a mask should continue to do so especially in public places and indoors, and they encourage folks to get the COVID-19 vaccine or booster if eligible.
