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Tag Archives: timing
Sundance Film Festival Unveils First Details On 2024 Hybrid Edition’s Slate, Venues & Timing As Fest Director Eugene Hernandez Addresses “Challenging Moment” For Artists – Deadline
- Sundance Film Festival Unveils First Details On 2024 Hybrid Edition’s Slate, Venues & Timing As Fest Director Eugene Hernandez Addresses “Challenging Moment” For Artists Deadline
- 2024 Sundance Film Festival In-Person, Hybrid Plans Announced IndieWire
- Sundance Film Festival Will Continue Hybrid Format in 2024 While Creating ‘Festive’ In-Person Event Variety
- Sundance Film Festival 2024 will screen more movies in person, fewer days online Salt Lake Tribune
- What to Know About the 2024 Sundance Film Festival – sundance.org Sundance Institute
- View Full Coverage on Google News
F1 Miami Grand Prix: Verstappen tops timing sheets ahead of Ferraris in FP2 after difficult morning session – Yahoo Sports
- F1 Miami Grand Prix: Verstappen tops timing sheets ahead of Ferraris in FP2 after difficult morning session Yahoo Sports
- 2023 Miami Grand Prix: Formula 1 Driver Special Edition Helmets Jalopnik
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- The novelty of South Florida hasn’t worn off: F1’s still all about ‘Miami vibe’ in Year 2 Miami Herald
- Max Verstappen Brings The MIAMI Heat | Oracle Virtual Laps at The #MiamiGP Oracle Red Bull Racing
- View Full Coverage on Google News
Timing Calorie Intake Synchronizes Circadian Rhythms Across Multiple Systems
Summary: Time-restricted eating influences gene expression over more than 22 regions in the brain and body. The findings have implications for a range of health disorders in which time-restricted eating appears to have potential benefits.
Source: Salk Institute
Numerous studies have shown health benefits of time-restricted eating including increase in life span in laboratory studies, making practices like intermittent fasting a hot topic in the wellness industry.
However, exactly how it affects the body on the molecular level, and how those changes interact across multiple organ systems, has not been well understood.
Now, Salk scientists show in mice how time-restricted eating influences gene expression across more than 22 regions of the body and brain. Gene expression is the process through which genes are activated and respond to their environment by creating proteins.
The findings, published in Cell Metabolism on January 3, 2023, have implications for a wide range of health conditions where time-restricted eating has shown potential benefits, including diabetes, heart disease, hypertension, and cancer.
“We found that there is a system-wide, molecular impact of time-restricted eating in mice,” says Professor Satchidananda Panda, senior author and holder of the Rita and Richard Atkinson Chair at Salk.
“Our results open the door for looking more closely at how this nutritional intervention activates genes involved in specific diseases, such as cancer.”
For the study, two groups of mice were fed the same high-calorie diet. One group was given free access to the food. The other group was restricted to eating within a feeding window of nine hours each day.
After seven weeks, tissue samples were collected from 22 organ groups and the brain at different times of the day or night and analyzed for genetic changes. Samples included tissues from the liver, stomach, lungs, heart, adrenal gland, hypothalamus, different parts of the kidney and intestine, and different areas of the brain.
The authors found that 70% of mouse genes respond to time-restricted eating.
“By changing the timing of food, we were able to change the gene expression not just in the gut or in the liver, but also in thousands of genes in the brain,” says Panda.
Nearly 40% of genes in the adrenal gland, hypothalamus, and pancreas were affected by time-restricted eating. These organs are important for hormonal regulation. Hormones coordinate functions in different parts of the body and brain, and hormonal imbalance is implicated in many diseases from diabetes to stress disorders. The results offer guidance to how time-restricted eating may help manage these diseases.
Interestingly, not all sections of the digestive tract were affected equally. While genes involved in the upper two portions of the small intestine—the duodenum and jejunum—were activated by time-restricted eating, the ileum, at the lower end of the small intestine, was not.
This finding could open a new line of research to study how jobs with shiftwork, which disrupts our 24-hour biological clock (called the circadian rhythm) impact digestive diseases and cancers. Previous research by Panda’s team showed that time-restricted eating improved the health of firefighters, who are typically shift workers.
The researchers also found that time-restricted eating aligned the circadian rhythms of multiple organs of the body.
“Circadian rhythms are everywhere in every cell,” says Panda. “We found that time-restricted eating synchronized the circadian rhythms to have two major waves: one during fasting, and another just after eating. We suspect this allows the body to coordinate different processes.”
Next, Panda’s team will take a closer look at the effects of time-restricted eating on specific conditions or systems implicated in the study, such as atherosclerosis, which is a hardening of the arteries that is often a precursor to heart disease and stroke, as well as chronic kidney disease.
See also
About this diet and genetics research news
Author: Press Office
Source: Salk Insititute
Contact: Press Office – Salk Institute
Image: The image is in the public domain
Original Research: Open access.
“Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals” by Shaunak Deota et al. Cell Metabolism
Abstract
Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals
Highlights
- 80% of genes are differentially expressed or rhythmic under TRF in at least one tissue
- TRF decreases genes involved in inflammatory signaling and glycerolipid metabolism
- TRF increases genes involved in RNA processing, protein folding, and autophagy
- TRF causes multi-tissue rewiring of BCAA, glucose, and lipid metabolism
Summary
Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health benefits that arise from multiple organ systems, yet the molecular basis of TRF-mediated benefits is not well understood.
Here, we subjected mice to isocaloric ad libitum feeding (ALF) or TRF of a western diet and examined gene expression changes in samples taken from 22 organs and brain regions collected every 2 h over a 24-h period.
We discovered that TRF profoundly impacts gene expression. Nearly 80% of all genes show differential expression or rhythmicity under TRF in at least one tissue. Functional annotation of these changes revealed tissue- and pathway-specific impacts of TRF.
These findings and resources provide a critical foundation for future mechanistic studies and will help to guide human time-restricted eating (TRE) interventions to treat various disease conditions with or without pharmacotherapies.
As Trevor Noah Heads For The Stage Door, ‘The Daily Show’ Team Shocked At Timing Of Exit – Deadline
“It’s been wild,” Trevor Noah told his audience after revealing that his “time is up” on hosting The Daily Show.
The news certainly was wildly unexpected.
Deadline understands that Noah told his studio audience of his departure before telling many members of the Comedy Central series’ staff — news that blindsided many.
The Daily Show sources said that it was “imperative” for Noah to share the news with his fans during Thursday’s taping as he wanted them to hear it from him first.
But the fact that Noah told a few hundred strangers, admittedly some die-hard fans but likely including many tourists keen to get a ticket to a show, before he told some members of his production team was hard to take for some.
Noah is thought to have quietly re-upped his deal earlier this year, and he and his team were recently celebrating scoring seven Emmy nominations – the most since he took over from Jon Stewart in 2015.
The comedian evidently is keen to get back on the road, while also trying new things. Noah, an incredibly popular figure on the live stand-up circuit, is performing Friday and Saturday at the Toronto Scotiabank Arena in Canada and has other shows booked in Halifax and Orlando over weekends off from The Daily Show.
He has been ramping up projects at his Day Zero Productions label as well, having recently hired Sanaz Yamin to run it as president, with former Marvel TV exec Devon Quinn hired last year to oversee live-action and animated TV.
Last year, the company said that it had 50 projects in development. Projects in the works have included a feature adaptation of Noah’s book Born a Crime and a reboot of The President’s Analyst, while there was talk of a mockumentary comedy series featuring Noah in the works with Paramount+. His documentary series The Tipping Point is expected to air on MSNBC and Peacock later this year.
It’s unclear how many people knew Noah was planning to make the announcement, but it evidently was a small number. Comedy Central made it clear that there was no timetable for his departure. The rollout of his exit was clearly not as organized as that of James Corden, for instance, who signed a one-year deal to remain on The Late Late Show with a view to a spring 2023 exit.
RELATED: ‘The Late Late Show’: CBS Looking To “Experiment” In Late-Night Slot As James Corden Prepares Exit
Noah’s exit, coupled with the coming departure of Corden, the cancellation of Full Frontal with Samantha Bee and the seemingly acrimonious split of Desus & Mero, highlights that there are big changes afoot in late-night.
While Jimmy Kimmel recently signed on to host his ABC show for another three years, and Jimmy Fallon and Seth Meyers have long-term contracts at NBC, it’s the biggest set of changes for the talk-show circuit in many years. Keep an eye on Stephen Colbert, it seems, and whether he decides to stick around at The Late Show.
For The Daily Show, the question is who’s next. Noah was a surprise choice for the position, which means his successor also could be a wild card. You would expect at least the next host of either The Daily Show or The Late Late Show to be a woman.
There’s also a deep bench of strong performers in the correspondent ranks: Ronny Chieng, Michael Kosta, Desi Lydic, Dulcé Sloan and Roy Wood Jr have all been there some time alongside gonzo reporter Jordan Klepper, who recently told Deadline that he does fancy another desk job at some stage.
On the production side, a new host would be the third for exec producer and showrunner Jen Flanz, who played a key role in the transition between Stewart and Noah and is expected to do the same with any such new table talker.
There’s also the question as to whether The Daily Show remains a linear premiere. The series is one of the few regular, original series left on Comedy Central’s linear schedule, given its parent company’s focus on Paramount+. All of these are yet to be figured out, but you’d bet that Paramount boss Bob Bakish is tasking Chris McCarthy, president and CEO of Paramount Media Networks, to make sure that he gets them right.
“What a journey’s it’s been,” Noah said. “It’s been absolutely amazing.”
Cognitive Health May Benefit From Balanced Meal Timing
Summary: Breakfast may very well be the most important meal of the day, especially in terms of maintaining good cognitive health. Researchers found skipping breakfast increases the risk of cognitive decline in middle-to-old age, while maintaining a temporal distribution of energy intake during a day helps maintain cognitive health.
Source: Higher Education Press
Globally, there are approximately 55 million people who suffer from dementia, and the incidence of the disease has steadily increased. The number of the population is expected to triple by 2050, particularly in low- and middle-income countries. Dementia affects not only the quality of life of individuals, but also adds significant economic burdens to families and society.
Epidemiological studies have shown a correlation between the temporal distribution of energy intake during a day (TPEI) and the risk of various chronic diseases such as diabetes and hypertension. However, evidence regarding the relationship between TPEI and cognitive function at the population level is relatively lacking.
Previous studies in animal models have shown that the disruption in meal timing can cause alterations in clock rhythms in the hippocampus, thereby affecting cognitive function.
According to a short-term intervention trial of 96 young adults, dividing equal amounts of food into four meals between 9 am and 3 pm could improve cognitive function compared to eating twice between 9 am and 3 pm. However, long-term study is lacking about the TPEIs and cognitive function.
Recently, Drs Changzheng Yuan and Dongmei Yu at Zhejiang University published a paper in Life Metabolism entitled “Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China”.
Based on the China Nutrition Health Survery (CHNS) public database, a total of 3,342 participants were included in this study, who were middle-aged and older adults (mean age 62 years) from nine provinces in China with a baseline age ≥ 55 years.
The researchers used: 1) A data-driven k-means algorithm to identify six patterns of TPEIs, including “evenly-distributed” pattern, “breakfast-dominant” pattern, “lunch-dominant” pattern, “dinner-dominant” pattern, “snack-rich” pattern, and “breakfast-skipping” pattern;
2) Cognitive function was assessed using the modified Telephone Interview for Cognitive Status (TICS-m), comprising immediate and delayed word recalls (20 points), backward counting (2 points), and serial-7 subtraction test (5 points). The total global cognitive score ranged from 0 to 27, with a higher score representing a better cognitive function;
3) The correlation of TPEIs to cognitive function over 10 years was assessed using linear mixed models (LMMs), which was adjusted for age, gender, residence, total energy, physical activity, smoking status, alcohol consumption, household income, education level, and body mass index (BMI).
The result showed that, compared with those with “evenly-distributed” pattern, the long-term cognitive function scores were significantly lower in those who had unbalanced TPEIs, especially those with “breakfast-skipping” pattern.
See also
Thus, maintaining balanced TPEIs has potentially positive effects on cognitive health, whereas skipping breakfast may significantly increase the risk of cognitive decline in middle-aged and older adults. In conclusion, this study highlights the importance of optimal TPEIs in cognitive function.
About this diet and cognition research news
Author: Shuqin He
Source: Higher Education Press
Contact: Shuqin He – Higher Education Press
Image: The image is in the public domain
Original Research: Open access.
“Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China” by Changzheng Yuan et al. Life Metabolism
Abstract
Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China
Worldwide, around 55 million people had prevalent dementia in 2019, which is expected to triple by 2050, especially in low- and middle-income countries Lacking timely diagnosis and limited effective treatment for dementia make identifying risk factors crucial for its early prevention, among which dietary factors have received increasing attention.
Study reveals timing of your largest meal has little effect on weight loss
The key to maintaining physical fitness is to live a healthy lifestyle. Regular exercise, a balanced diet, self-care, and good sleeping patterns too helps.
However, if you are trying to achieve all of this while trying to lose weight, there are several websites with tips to help you reduce quickly. But it is important to lose weight in a healthy way. Choosing healthy food and appropriate mealtimes can significantly affect how much weight you lose. This has become one of the most popular diet tips in recent years.
It has been advised to eat a substantial meal first thing in the morning and to keep subsequent meals on the smaller side if you wish to lose weight. The logic behind this is that all body cells function on the same 24-hour cycle as humans, regulating the majority of our biological processes, including metabolism.
Also read | More than quarter healthy teenagers are on diet to lose weight, says study
Scientists recently suggested that our digestion changes throughout the day as a result of our metabolic rate. This study is known as chrono-nutrition.
According to two studies published in 2013, eating more calories in the morning and fewer at night is beneficial for weight loss. However, to contradict this, a recent study found that the proportion of breakfast and dinner affects self-reported appetite and doesn’t affect weight loss and metabolism.
The study was conducted by researchers from the Universities of Aberdeen and Surrey on healthy, overweight participants to examine the link between breakfast and dinner and how it affects appetite.
The researchers, keeping the lunch the same, either gave a heavy breakfast and a light dinner or vice versa, to keep track of how many calories the research participants were ingesting and assess metabolism.
The researchers anticipated that a large breakfast and a light dinner would enhance calorie burn and increase weight loss, but the research showed distinctions between the two meal patterns in terms of body weight. Additionally, there were no variations in the average daily levels of lipids, insulin, or blood sugar.
Also read | Expert talks about plant-based diets and why they are beneficial for us
The research suggests that processing calories differently in the morning compared to the evening does not affect weight loss in the way it has been suggested in the studies.
Although consuming a heavy breakfast, it was noticed that participants were feeling less hungry. This might act as an advantage as it makes it easier to curb their appetite and eat fewer calories.
Additionally, there is growing evidence that meal time can have a significant impact on many people’s health. However, new research suggests that the timing of your largest meal may not be as important in weight loss as previously thought.
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Slowing of continental plate movement controlled the timing of Earth’s largest volcanic events
Scientists have shed new light on the timing and likely cause of major volcanic events that occurred millions of years ago and caused such climatic and biological upheaval that they drove some of the most devastating extinction events in Earth’s history.
Surprisingly, the new research, published today in Science Advances, suggests a slowing of continental plate movement was the critical event that enabled magma to rise to the Earth’s surface and deliver the devastating knock-on impacts.
Earth’s history has been marked by major volcanic events, called large igneous provinces (LIPs)—the largest of which have caused major increases in atmospheric carbon emissions that warmed Earth’s climate, drove unprecedented changes to ecosystems, and resulted in mass extinctions on land and in the oceans.
Using chemical data from ancient mudstone deposits obtained from a 1.5 km-deep borehole in Wales, an international team led by scientists from Trinity College Dublin’s School of Natural Sciences was able to link two key events from around 183 million years ago (the Toarcian period).
The team discovered that this time period, which was characterized by some of the most severe climatic and environmental changes ever, directly coincided with the occurrence of major volcanic activity and associated greenhouse gas release on the southern hemisphere, in what is nowadays known as southern Africa, Antarctica and Australia.
On further investigation—and more importantly—the team’s plate reconstruction models helped them discover the key fundamental geological process that seemed to control the timing and onset of this volcanic event and others of great magnitude.
Micha Ruhl, assistant professor in Trinity’s School of Natural Sciences, led the team. He said, “Scientists have long thought that the onset of upwelling of molten volcanic rock, or magma, from deep in Earth’s interior, as mantle plumes, was the instigator of such volcanic activity but the new evidence shows that the normal rate of continental plate movement of several centimeters per year effectively prevents magma from penetrating Earth’s continental crust.
“It seems it is only when the speed of continental plate movement slows down to near zero that magmas from mantle plumes can effectively make their way to the surface, causing major large igneous province volcanic eruptions and their associated climatic perturbations and mass extinctions.
“Crucially, further assessment shows that a reduction in continental plate movement likely controlled the onset and duration of many of the major volcanic events throughout Earth’s history, making it a fundamental process in controlling the evolution of climate and life at Earth’s surface throughout the history of this planet.”
The study of past global change events, such as in the Toarcian, allows scientists to disentangle the different processes that control the causes and consequences of global carbon cycle change and constrain fundamental Earth system processes that control tipping points in Earth’s climate system.
Scientists show solar system processes control the carbon cycle throughout Earth’s history
More information:
Micha Ruhl, Reduced plate motion controlled timing of Early Jurassic Karoo-Ferrar large igneous province volcanism, Science Advances (2022). DOI: 10.1126/sciadv.abo0866. www.science.org/doi/10.1126/sciadv.abo0866
Micha Ruhl, Reduced plate motion controlled timing of Early Jurassic Karoo-Ferrar large igneous province volcanism, Science Advances (2022). DOI: 10.1126/sciadv.abo0866. www.science.org/doi/10.1126/sciadv.abo0866
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Timing of Artemis launch may depend on emergency detonation system
Formally known as the Flight Termination System, it is a detonation system designed to destroy the rocket in case it starts to veer wildly off course and threaten people on the ground. In the dangerous world of rocketry, it’s a vital and ubiquitous safety component, operated by the military. But it’s also creating a bit of a headache for NASA as it struggles to launch the SLS rocket for the first time.
The Space Force requires the batteries on the SLS’s termination system to be recharged every so often to ensure they are in good working order. The problem for NASA is that can only be done in the rocket’s assembly building, meaning they would need to perform the arduous work of rolling the 322-foot-tall rocket off the pad, where it is now, back to the building four miles away — a journey that can take about eight hours each way.
That would further delay a launch that last week was waived off twice because of other technical problems, including a massive leak of the liquid hydrogen the rocket uses for fuel.
NASA already got the Space Force to extend the flight-termination battery requirement from 20 to 25 days so that it could attempt a launch in the latter part of its last launch period, which ended Tuesday.
Now, NASA is in discussions with the Space Force for a waiver that would allow the time frame to be extended yet again. But this time the waiver would have to extend the initial 20-day requirement to over some 40 days, since the earliest NASA could attempt a launch is a two-week period that begins Sept. 19.
The launch would be the first in NASA’s Artemis campaign to eventually return astronauts to the lunar surface. This first mission would send the Orion spacecraft, without any astronauts on board, in orbit around the moon. It would be followed by a crewed flight that would again orbit, but not land on the moon, perhaps in 2024, with a landing to come in 2025 or 2026.
After years of delays and setbacks, NASA officials are eager to get the first mission off the ground. But they’ve struggled with a series of issues. The first attempt was scrubbed because of a bad engine sensor reading. Then, on Saturday, they could not control a large hydrogen leak and said there was also a sudden increase in the pressure of the fuel line that caught officials by surprise.
Now, it’s struggling with the constraints of the termination system, and it is not clear whether the Space Force’s Space Launch Delta 45, which oversees what’s known as the Eastern Range, would grant the extension.
“The first thing is to protect the public and the Eastern Range takes that mandate to protect the public very seriously,” said Wayne Hale, a former NASA space shuttle flight director who now chairs a NASA advisory committee. Rockets, he said in an interview, are “effectively a bomb, it’s a huge bomb” and the wing goes to great lengths to ensure the termination systems are working before they allow launches to occur.
“They are consummate professionals,” said Wayne Monteith, the former commander of the 45th Space Wing. “If something goes wrong, they are they team you want on console.”
NASA said Tuesday evening that engineers would replace the seal that malfunctioned during the hydrogen leak on the launchpad, instead of rolling it back to the assembly building. That would allow it to test the seal by running the liquid hydrogen, which is kept at minus 423 degrees Fahrenheit, through it.
“Performing that work at the pad also allows teams to gather as much data as possible to understand the cause of the issue,” NASA said in a statement.
There is a downside, though — the longer the rocket is outside, the longer it is exposed to the fickle weather that is common along the Florida Coast this time of year.
“We are mindful that we’re out there in the elements when we’re at the pad,” Mike Sarafin, the Artemis mission manager, told reporters after the scrub on Saturday.
While it does the repair work, NASA said it would “set up an enclosure around the work area to protect the hardware from the weather and other environmental conditions, but enables engineers to test the repair under cryogenic, or supercold, conditions.”
It noted that in order “to meet the current requirement” the Space Force has for the flight termination batteries, it “would need to roll the rocket and spacecraft back” to the assembly building to reset the batteries.
If that is the case, NASA may not be able to attempt another launch until the next opportunity, a roughly two-week period that begins Oct. 4. The SLS’s ability to launch is determined by the position of the Earth and moon, since the Orion spacecraft cannot be in darkness for more than 90 minutes at a time. Its solar arrays need to stay illuminated so that they can provide power to the spacecraft and ensure it maintains the correct temperature.
[VIDEO] ‘Wheel Of Fortune’ Woman Loses Puzzle, Timing Rule Explained
Wheel of Fortune left its viewers spinning on Tuesday when a contestant was denied her grand prize (a new Audi!) in the final round, despite correctly solving the puzzle.
Here’s what happened to poor Charlene: The category of her final puzzle was “What Are You Doing,” and the correct answer was “Choosing the right word.” Factoring in the usual letters every contestant is given for a puzzle, combined with her own guesses, she started out with “-h–sing the right –rd.”
“Choosing the right… card?” she guessed. And understandably so, given that the holiday season is upon us. Unfortunately, that was incorrect. So she started again with “Choosing the right…” before taking several seconds to think. And she indeed blurted out “word!” before the clock ran out. So why isn’t Charlene headbanging to “All I Want for Christmas Is You” in her brand-new Audi as we speak?
“This one’s tough because you said all the right words, including the word ‘word,’ but as you know, it’s got to be more or less continuous,” host Pat Sajak told her. “We’ll allow for a little pause, but not four or five seconds. I’m sorry. You did a good job in getting it, but we can’t give you the prize and it was the Audi.”
That’s right — even though Charlene said all the right words in order, the pause between “right” and “word” was considered too long, essentially splitting her single guess into two.
Even Alex Jacob, the winner of Jeopardy!‘s 2015 Tournament of Champions, chimed in with his displeasure: “Come on @WheelofFortune, the woman literally chose the right word. Give her the car,” he tweeted, later adding, “I understand rules are rules but this seems like a particularly dumb rule. C’mon Wheel, it’s Christmas.”
Watch Charlene’s controversial Wheel moment via Jacob’s tweet below:
Come on @WheelofFortune, the woman literally chose the right word. Give her the car. pic.twitter.com/aAaMyFeEZl
— Alex Jacob (@whoisalexjacob) December 22, 2021
And while many viewers tweeted their disappointment with the outcome, one previous Wheel winner (a true historian!) provided context about how the strictness of this particular rule has changed over the years:
Here is a comparison of other Wheel of Fortune Bonus Rounds with pauses. Although they were stricter about it back in 2013, it seems they now draw the line at 3 or 4 seconds. A 2.7s pause was okay, but a 4.9-5.0s pause is not. #WheelofFortune #ChoosingTheRightWord #Audi pic.twitter.com/4Fgs8JrqqO
— WheelRob (@WheelRob10) December 22, 2021
Where do you stand on this polarizing Wheel rule? Drop a comment with your thoughts below, including whether Charlene deserves that Audi.