Tag Archives: ticking

FDA approves new drug that may help stop and even reverse a rare, fatal condition that doctors call a ‘ticking time bomb’ – CNN

  1. FDA approves new drug that may help stop and even reverse a rare, fatal condition that doctors call a ‘ticking time bomb’ CNN
  2. FDA approves Merck’s drug for rare, deadly lung condition CNBC
  3. FDA Approves Merck’s WINREVAIR™ (sotatercept-csrk), a First-in-Class Treatment for Adults with Pulmonary Arterial Hypertension (PAH, WHO* Group 1) Merck
  4. FDA Approves Sotatercept, First-in-Class Treatment for Adults With PAH AJMC.com Managed Markets Network
  5. Merck’s $11.5 Billion Bet on Its Next Big Drug Finally Arrives The Wall Street Journal

Read original article here

Lockdowns have created a ‘ticking cancer timebomb’: Doctors warn it’ll be YEARS before death rates return to p – Daily Mail

  1. Lockdowns have created a ‘ticking cancer timebomb’: Doctors warn it’ll be YEARS before death rates return to p Daily Mail
  2. Smoking-related cancers are declining in NYC, but vaping and e-cigs raise concerns Gothamist
  3. US cancer report details how diagnoses dropped during the COVID-19 pandemic FierceBiotech
  4. Annual Report to the Nation Part 2: New cancer diagnoses fell abruptly early in the COVID-19 pandemic | CDC Online Newsroom CDC
  5. Doctors work to ‘make up for lost ground’ from cancer screenings that were missed, delayed during pandemic CNN
  6. View Full Coverage on Google News

Read original article here

LeBrun: Clock ticking on Coyotes as Gary Bettman lays out NHL’s options for relocation and expansion – The Athletic

  1. LeBrun: Clock ticking on Coyotes as Gary Bettman lays out NHL’s options for relocation and expansion The Athletic
  2. Bettman ‘hopeful’ NHL will find solution for Coyotes in Arizona – ESPN ESPN
  3. NHL commish doubles down on desire to keep Coyotes in Arizona amid failed arena vote: ‘We’ll make it work’ Fox News
  4. News From Gary Bettman’s Annual “State Of The Union” Press Conference: Salary Cap, Expansion, Arizona Coyotes, Ottawa Senators NoVa Caps
  5. Bettman discusses the Coyotes, possible expansion and more at state of the league address TSN
  6. View Full Coverage on Google News

Read original article here

Timothée Chalamet and Zendaya Only Had an Hour Each Day to Film ‘Dune: Part Two’ Romance Scenes at Sunset: ‘There’s a Ticking Timer’ – Variety

  1. Timothée Chalamet and Zendaya Only Had an Hour Each Day to Film ‘Dune: Part Two’ Romance Scenes at Sunset: ‘There’s a Ticking Timer’ Variety
  2. ‘Dune: Part Two’—An Exclusive First Look at the Saga’s Epic Conclusion Vanity Fair
  3. Zendaya and Timothée Chalamet Only Had an Hour Each Day to Film Sunset Romance Scenes for ‘Dune: Part Two’ Hollywood Reporter
  4. Timothée Chalamet Hypes Zendaya At CinemaCon 2023 BuzzFeed
  5. Zendaya’s Louis Vuitton Era Began at CinemaCon Go Fug Yourself
  6. View Full Coverage on Google News

Read original article here

U.N. Warns “Climate Time Bomb Is Ticking” as Cyclone Freddy Death Toll Tops 560 in Malawi & Mozambique – Democracy Now!

  1. U.N. Warns “Climate Time Bomb Is Ticking” as Cyclone Freddy Death Toll Tops 560 in Malawi & Mozambique Democracy Now!
  2. Survivors reel in aftermath of 1 of Africa’s deadliest cyclones ABC News
  3. Half a Million Displaced in Malawi by Cyclone: Humanitarian Needs Soar International Organization for Migration (IOM)
  4. UN Warns “Climate Time Bomb Is Ticking” as Cyclone Freddy Death Toll Tops 560 in Malawi & Mozambique Democracy Now!
  5. Mozambique’s Cholera Death Toll Doubles in Cyclone Hit Region Voice of America – VOA News
  6. View Full Coverage on Google News

Read original article here

OpenAI CEO Sam Altman warns that other A.I. developers working on ChatGPT-like tools won’t put on safety limits—and the clock is ticking – Fortune

  1. OpenAI CEO Sam Altman warns that other A.I. developers working on ChatGPT-like tools won’t put on safety limits—and the clock is ticking Fortune
  2. OpenAI CEO Worried That ChatGPT May ‘Eliminate Lot Of Current Jobs’ NDTV
  3. OpenAI CEO Sam Altman warns that other A.I. developers working on ChatGPT-like tools won’t put on safety limits—and the clock is ticking Yahoo Finance
  4. OpenAI CEO, CTO on risks and how AI will reshape society ABC News
  5. Sam Altman ‘a little bit scared’ of ChatGPT, will eliminate ‘many’ jobs Business Insider
  6. View Full Coverage on Google News

Read original article here

Are fat-loss shots a ticking timebomb? Doctors warn Ozempic & Wegovy are shrinking patients’ muscles – Daily Mail

  1. Are fat-loss shots a ticking timebomb? Doctors warn Ozempic & Wegovy are shrinking patients’ muscles Daily Mail
  2. Weight loss drug semaglutide causes muscle loss, doctor warns Insider
  3. A doctor warns that weight-loss drug semaglutide is shrinking patients’ muscle mass at an alarming rate msnNOW
  4. Trendy weight-loss drug Ozempic is now a Hollywood punchline. See how doctors and clinics are using TikTok to Business Insider India
  5. A doctor warns that weight-loss drug semaglutide is shrinking patients’ muscle mass at an alarming rate Yahoo News
  6. View Full Coverage on Google News

Read original article here

Putin has his back to the wall with the clock ticking ever louder



CNN
 — 

Time is running out for Russian President Vladmir Putin, and he knows it.

Meanwhile his bombast continues: announcing the annexation of Ukrainian territories on Friday, Putin declared Luhansk, Donetsk, Zaporizhzhia and Kherson will become part of Russia “forever.” He is rushing to claim a victory and cement slender gains and sue for peace, running a dangerous political tab, regardless of the fanfare in Moscow.

He called on Ukraine to “cease fire” immediately and “sit down at the negotiating table,” but added: “We will not negotiate the choice of the people. It has been made. Russia will not betray it.”

He is doing his best to hide it, but he is losing his war in Ukraine. The writing is on the wall.

Andrey Kortunov, who runs the Kremlin-backed Russian International Affairs Council in Moscow, sees it, too. “President Putin wants to end this whole thing as fast as possible,” he told CNN.

Putin’s recent heavy-handed conscription drive for 300,000 troops won’t reverse his battlefield losses any time soon, and is backfiring at home, running him up a dangerous political tab.

According to official data from the EU, Georgia and Kazakhstan, around 220,000 Russians have fled across their borders since the “partial mobilization” was announced. The EU said its numbers – nearly 66,000 – represented a more than 30% increase from the previous week.

Ex-oligarch says Putin made a dangerous move and is risking his life

Independent Russian media quoting Russia’s revamped KGB, the FSB, put the total exodus even higher. They say more military age men have fled the country since conscription – 261,000 – than have so far fought in the war – an estimated 160,000 to 190,000.

CNN is unable to verify the Russian figures, but the 40 kilometers (around 25 miles) traffic tailbacks at the border with Georgia, and the long lines at crossings into Kazakhstan and Finland, speak to the backlash and the strengthening perception that Putin is losing his fabled touch at reading Russia’s mood.

The clock ticks loudly for Putin because his back is against the wall.

Kortunov says he doesn’t know what goes on in the Kremlin but that he understands the public mood over the huge costs and loss of life in the war. “Many people would start asking questions, why did we get into this mess? Why, you know, we lost so many people.”

Putin’s logical option, Kortunov says, is to declare victory and get out on his own terms. But for this he needs a significant achievement on the ground. “Russia cannot simply get to where it was, on the 24 February of this year, say, okay, you know, that’s fine. Our mission is accomplished. So we go home… …There should be something that can be presented to the public as a victory.”

And this is the logic Putin appears to be following, rubber-stamping the sham referendums in Ukraine’s Luhansk, Donetsk, Zaporizhzhia and Kherson regions, and declaring them part of Russia.

He used the same playbook annexing Crimea from Ukraine in 2014 and now, like then, threatens potential nuclear strikes should Ukraine, backed by its Western allies, try to take the annexed territories back.

Western leaders are in a battle of brinksmanship with Putin. Last Sunday US national security adviser Jake Sullivan told NBC’s “Meet the Press” Washington would respond decisively if Russia deployed nuclear weapons against Ukraine and has made clear to Moscow the “catastrophic consequences” it would face.

Leaders have also vowed not to recognize the regions as part of Russian territory.

US President Joe Biden said Moscow’s actions have “no legitimacy,” adding that Washington will continue to “always honor Ukraine’s internationally recognized borders.” The European Union said it “will never” recognize the Kremlin’s “illegal annexation,” and described the move as a “further violation of Ukraine’s independence, sovereignty and territorial integrity.”

Hear what worries Sen. Rubio more than a Russian nuclear attack

There is little new in what Putin does, which, if nothing else, is making his moves more predictable, and therefore more readily analyzed.

Kurt Volker, who was US ambassador to NATO and US special representative to Ukraine under former President Donald Trump, believes Putin maybe gearing up for peace. “I think what he must be striving for, is to brandish the nuclear weapons, make all kinds of threats to Europe, and then say, okay, so let’s negotiate a settlement. And let me keep what I have already taken.”

Fiona Hill, who has advised three US Presidents on national security about Russia, also thinks Putin may be attempting an end game. “He feels a sense of acute urgency that he was losing momentum, and he’s now trying to exit the war in the same way that he entered it. With him being the person in charge and him framing the whole terms of any kind of negotiation. “

If these analyses are correct, they go a long way toward explaining the mystery of what happened under the Baltic Sea on Monday.

Both Danish and Swedish seismologists recorded explosive shockwaves from close to the seabed: the first, at around 2 a.m. local time, hitting 2.3 magnitude, then again, at around 7 p.m., registering 2.1.

Within hours, roiling patches of sea were discovered, the Danes and the Germans sent warships to secure the area, and Norway increased security around its oil and gas facilities.

So far, at least four leaks in Russia’s Nord Stream pipelines 1 and 2 have been discovered, each at the surface resembling a boiling cauldron, the largest one kilometer across, and together spewing industrial quantities of toxic greenhouse gases into the atmosphere.

Russian naval vessels were seen by European security officials in the area in the days prior, Western intelligence sources have said. NATO’s North Atlantic Council has described the damage as a “deliberate, reckless and irresponsible act of sabotage.”

Russia denies responsibility and says it has launched its own investigation. But former CIA chief John Brennan said Russia has the expertise to inflict this type of damage “all the signs point to some type of sabotage that these pipelines are only in about 200 feet or so of water and Russia does have an undersea capability to that will easily lay explosive devices by those pipelines.”

Brennan’s analysis is that Russia is the most likely culprit for the sabotage, and that Putin is likely trying to send a message: “It’s a signal to Europe that Russia can reach beyond Ukraine’s borders. So who knows what he might be planning next.”

Nord Stream 2 was never operational, and Nord Stream 1 had been throttled back by Putin as Europe raced to replenish gas reserves ahead of winter, while dialling back demands for Russian supplies and searching for replacement providers.

The Nord Stream pipeline sabotage could, according to Hill, be a last roll of the dice by Putin, so that “there’s no kind of turning back on the gas issues. And it’s not going to be possible for Europe to continue to build up its gas reserves for the winter. So what Putin is doing is throwing absolutely everything at this right now.”

Another factor accelerating Putin’s thinking may be the approach of winter. Napoleon and Hitler both failed to take Moscow as supply lines running through Ukraine were too long and arduous in winter. Volker says that what historically saved Russia is now pressing down on Putin: “This time, it’s Russia that has to supply lines, trying to sustain its forces in Ukraine. That’s going to be very hard this winter. So all of a sudden, for all these factors, Putin’s timeline has moved up.”

The bottom line, said Hill, is that “this is the result of Ukraine gaining momentum on the ground on the battlefield and of Putin himself losing it, so he’s trying to adapt to the circumstances and basically take charge and get every advantage.”

No one knows what’s really going on in Putin’s mind. Kortunov doubts Putin will be willing to compromise beyond his own terms for peace, “not on the terms that are offered by President Zelensky, not on the terms which are offered by the West… .[though] he should be ready to exercise a degree of flexibility. But we don’t know what these degrees [are] likely to be.”

According to Hill, Putin wants his negotiations to be with Biden and allies, not Ukraine: “He’s basically saying now you will have to negotiate with me and sue for peace. And that means recognizing what we have done on the ground in Ukraine.”

Having failed in the face of Western military unity backing Ukraine, Putin appears set to test Western resolve diplomatically, by trying to divide Western allies over terms for peace.

Volker expects Putin to pitch France and Germany first “to say, we need to end this war, we’re going to protect our territories at all costs, using any means necessary, and you need to put pressure on the Ukrainians to settle.”

If this is Putin’s plan, it could turn into his biggest strategic miscalculation yet. There is little Western appetite to see him stay in power – US Secretary of Defense Lloyd Austin said as much in the summer – and even less to let down Ukraine after all its suffering.

Putin knows he is in a corner, but doesn’t seem to realize how small a space he has, and that of course is what’s most worrying – would he really make good on his nuclear threats?

The war in Ukraine may have entered a new phase, and Putin may have his back against the wall, but an end to the conflict could still be a very long way off.

Read original article here

Astronomers observe celestial ‘ticking time bomb’ for first time

For the first time, astronomers have observed the final days and death throes of a red supergiant star before its final collapse and massive explosion into a supernova.

Supernovas are usually only detected after they happen, although a few of a different type have been caught in the act of exploding. In this case, scientists detected the star in its final stages about 130 days before it detonated, and they were able to watch it grow progressively brighter and, at last, blow up.

“It’s like watching a ticking time bomb,” astrophysicist Raffaella Margutti, the senior author of a study of the supernova published last week in the Astrophysical Journal, said in a statement. “We’ve never confirmed such violent activity in a dying red supergiant star where we see it produce such a luminous emission, then collapse and combust, until now.”

Margutti is now an associate professor of astronomy and physics at the University of California, Berkeley, but she carried out the study while at Northwestern University’s Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) at Evanston, Illinois.

The lead author of the new study is Margutti’s graduate student, astrophysicist Wynn Jacobson-Galán, who was also at Northwestern for the observations but has since joined UC Berkeley.

Jacobson-Galán said that the star was detected in the summer of 2020 during a survey by the University of Hawaii’s Pan-STARRS telescope on the peak of the Haleakalā volcano on Maui.

Although the star was in a galaxy about 120 million light-years away — both the star and the galaxy are too faint to be seen by the naked eye — the data from Pan-STARRS showed the star had become much brighter than usual, he said.

The scientists then kept watch on the star with the Pan-STARRS telescope, which showed it was violently ejecting large amounts of gas.

When the final supernova explosion did occur, they were able to capture the powerful flash it emitted — for a brief moment, it was brighter than all the other stars in that galaxy combined — thanks to CIERA’s ability to remotely operate the telescopes at the W.M Keck Observatory atop Mauna Kea on Hawaii.

The supernova flash and the observations that followed showed the star was surrounded by shells of gas when it exploded — probably the same gas it had emitted in the month leading up to the detonation.

A few other supernovas have been seen before, but not of this type. Instead, they’ve typically been when a giant star has collided with its binary companion, Jacobson-Galán said.

But in this case, there seemed to be no other stars involved in the explosion.

“These types of supernovae come from a massive star and it’s usually a red supergiant,” he said. “And that’s what we saw — they are one of the more common supernovae in the universe.”

Observations after the explosion suggest the star was about 10 times larger than our sun — near the lower end of the range for stars that become supernovas.

Stars like our sun are too small to become supernovas. They’ll expand and then shrink into a white dwarf at the end of their lifetimes.

Smaller stars also last several billion years, Jacobson-Galán said, because they’re not so large that they burn up all their fusion fuel in a short time.

Red giants like the supernova in the study, however, can use their fuel in only a few hundred million years, and then collapse when they can’t carry out fusion anymore.

The final supernova is caused by the outer shells of the star “bouncing” off its core.

“That propagates outwards and unbinds the whole star,” he said. “It rips through the star and pushes all the layers out really fast.”

Supernovas are the final stages of many stars, and they are responsible for seeding interstellar clouds of gas and dust with “heavy” chemical elements. The clouds seeded by the explosions then coalesce into younger stars, like the sun, and the elements — such as carbon, oxygen, silicon and iron — are incorporated into their planets.

Previously, the “old age” of massive stars has been almost impossible to observe, said Matt Nicholl, a lecturer in physics and astronomy at the University of Birmingham in the United Kingdom. “Before now, we’ve never been able to study this crucial phase directly,” he said in an email.

Nicholl was not involved in the latest study but he led a team that discovered the brightest supernova ever seen.

He said dedicated robotic telescopes like Pan-STARRS could now survey the sky looking for explosive events like supernovas, and more were likely to be found as the surveys became more effective.

Although Jacobson-Galán proposes that the brightening of the star before it became a supernova was a consequence of its final stages, Albert Zijlstra, a professor of astrophysics at the University of Manchester in the U.K., said in an email that the brightening may have been unrelated.

Zijlstra was not involved in the new study but he is an expert on supernovas. He was part of a team that determined which star exploded to create the supernova seen over China in 1181 A.D.

He points to a similar star, Eta Carinae, about 7,500 light-years away, which is emitting vast clouds of gas and becomes much brighter for many years at a time, but then fades away again without exploding.

“They’ve seen a brightening before the explosion, but there’s no way to know that the star didn’t do the same thing 10 years ago,” Zijlstra said. “So we don’t know whether the two things are related.”

Read original article here

Astronomers observe celestial ‘ticking time bomb’ for first time

For the first time, astronomers have observed the final days and death throes of a red supergiant star before its final collapse and massive explosion into a supernova.

Supernovas are usually only detected after they happen, although a few of a different type have been caught in the act of exploding. In this case, scientists detected the star in its final stages about 130 days before it detonated, and they were able to watch it grow progressively brighter and, at last, blow up.

“It’s like watching a ticking time bomb,” astrophysicist Raffaella Margutti, the senior author of a study of the supernova published last week in the Astrophysical Journal, said in a statement. “We’ve never confirmed such violent activity in a dying red supergiant star where we see it produce such a luminous emission, then collapse and combust, until now.”

Margutti is now an associate professor of astronomy and physics at the University of California, Berkeley, but she carried out the study while at Northwestern University’s Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) at Evanston, Illinois.

The lead author of the new study is Margutti’s graduate student, astrophysicist Wynn Jacobson-Galán, who was also at Northwestern for the observations but has since joined UC Berkeley.

Jacobson-Galán said that the star was detected in the summer of 2020 during a survey by the University of Hawaii’s Pan-STARRS telescope on the peak of the Haleakalā volcano on Maui.

Although the star was in a galaxy about 120 million light-years away — both the star and the galaxy are too faint to be seen by the naked eye — the data from Pan-STARRS showed the star had become much brighter than usual, he said.

The scientists then kept watch on the star with the Pan-STARRS telescope, which showed it was violently ejecting large amounts of gas.

When the final supernova explosion did occur, they were able to capture the powerful flash it emitted — for a brief moment, it was brighter than all the other stars in that galaxy combined — thanks to CIERA’s ability to remotely operate the telescopes at the W.M Keck Observatory atop Mauna Kea on Hawaii.

The supernova flash and the observations that followed showed the star was surrounded by shells of gas when it exploded — probably the same gas it had emitted in the month leading up to the detonation.

A few other supernovas have been seen before, but not of this type. Instead, they’ve typically been when a giant star has collided with its binary companion, Jacobson-Galán said.

But in this case, there seemed to be no other stars involved in the explosion.

“These types of supernovae come from a massive star and it’s usually a red supergiant,” he said. “And that’s what we saw — they are one of the more common supernovae in the universe.”

Observations after the explosion suggest the star was about 10 times larger than our sun — near the lower end of the range for stars that become supernovas.

Stars like our sun are too small to become supernovas. They’ll expand and then shrink into a white dwarf at the end of their lifetimes.

Smaller stars also last several billion years, Jacobson-Galán said, because they’re not so large that they burn up all their fusion fuel in a short time.

Red giants like the supernova in the study, however, can use their fuel in only a few hundred million years, and then collapse when they can’t carry out fusion anymore.

The final supernova is caused by the outer shells of the star “bouncing” off its core.

“That propagates outwards and unbinds the whole star,” he said. “It rips through the star and pushes all the layers out really fast.”

Supernovas are the final stages of many stars, and they are responsible for seeding interstellar clouds of gas and dust with “heavy” chemical elements. The clouds seeded by the explosions then coalesce into younger stars, like the sun, and the elements — such as carbon, oxygen, silicon and iron — are incorporated into their planets.

Previously, the “old age” of massive stars has been almost impossible to observe, said Matt Nicholl, a lecturer in physics and astronomy at the University of Birmingham in the United Kingdom. “Before now, we’ve never been able to study this crucial phase directly,” he said in an email.

Nicholl was not involved in the latest study but he led a team that discovered the brightest supernova ever seen.

He said dedicated robotic telescopes like Pan-STARRS could now survey the sky looking for explosive events like supernovas, and more were likely to be found as the surveys became more effective.

Although Jacobson-Galán proposes that the brightening of the star before it became a supernova was a consequence of its final stages, Albert Zijlstra, a professor of astrophysics at the University of Manchester in the U.K., said in an email that the brightening may have been unrelated.

Zijlstra was not involved in the new study but he is an expert on supernovas. He was part of a team that determined which star exploded to create the supernova seen over China in 1181 A.D.

He points to a similar star, Eta Carinae, about 7,500 light-years away, which is emitting vast clouds of gas and becomes much brighter for many years at a time, but then fades away again without exploding.

“They’ve seen a brightening before the explosion, but there’s no way to know that the star didn’t do the same thing 10 years ago,” Zijlstra said. “So we don’t know whether the two things are related.”

Read original article here