Tag Archives: structure

Inside mysterious ‘giant structure’ found deep in Australia that scientists think reveals ancient wor… – The US Sun

  1. Inside mysterious ‘giant structure’ found deep in Australia that scientists think reveals ancient wor… The US Sun
  2. Scientists Intrigued by Huge Structure Buried Under Australia Futurism
  3. The largest known asteroid impact structure on Earth is buried in southeast Australia, new evidence suggests Yahoo! Voices
  4. Huge structure discovered at the bottom of the ocean could be the biggest on the planet Daily Star
  5. Buried object with ‘magnetic anomalies’ may be Utah-sized asteroid crater, study says Miami Herald
  6. View Full Coverage on Google News

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Democrats Say Republicans Giving Crypto and Wall Street a ‘Handout’ With New Digital Asset Market Structure Bill – The Daily Hodl

  1. Democrats Say Republicans Giving Crypto and Wall Street a ‘Handout’ With New Digital Asset Market Structure Bill The Daily Hodl
  2. House Crypto Bill Won’t Restrain SEC and Could Threaten DeFi, Legal Experts Say Decrypt
  3. Committees Introduce Financial Innovation and Technology for the 21st Century Act House Financial Services Committee
  4. SEC failure proves need for congressional crypto legislation The Hill
  5. News Explorer — House Crypto Bill Won’t Restrain SEC and Could Threaten DeFi, Legal Experts Say Decrypt
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Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane – Nature.com

  1. Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane Nature.com
  2. Is discontinuing universal SARS-CoV-2 testing at hospital admission in England and Scotland associated with increased hospital-onset infections? News-Medical.Net
  3. New monoclonal antibodies targeting ACE2 receptor could treat the next waves of SARS-CoV-2 Medical Xpress
  4. Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy Nature.com
  5. A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection News-Medical.Net
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State-level macro-economic factors moderate the association of low income with brain structure and mental health in U.S. children – Nature.com

  1. State-level macro-economic factors moderate the association of low income with brain structure and mental health in U.S. children Nature.com
  2. Anti-poverty programs may help reduce disparities in brain development and mental health symptoms in children National Institutes of Health (.gov)
  3. Larger welfare checks lead to healthier brains, study finds The Hill
  4. Poverty hurts young brains but social safety net may help Harvard Gazette
  5. Anti-poverty programs may help reduce disparities in brain development and mental health symptoms in children | National Institute on Drug Abuse National Institute on Drug Abuse
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Fresenius Medical Care proposes to its shareholders to change its legal form to simplify the governance structure and strengthen shareholder rights – Fresenius Medical Care

  1. Fresenius Medical Care proposes to its shareholders to change its legal form to simplify the governance structure and strengthen shareholder rights Fresenius Medical Care
  2. Germany’s Fresenius to simplify structure, flags potential profit fall Yahoo Finance
  3. Breakingviews – Fresenius takes tentative step on road to breakup Reuters
  4. Fresenius Medical Care delivers against FY22 expectations, sets strategic focus and accelerates transformation Fresenius Medical Care
  5. Fresenius Slides as Earnings Disappoint, Clouding CEO’s Revamp Bloomberg
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Bitcoin price eyes $22K rebound with BTC market structure ‘not yet broken’ – Cointelegraph

  1. Bitcoin price eyes $22K rebound with BTC market structure ‘not yet broken’ Cointelegraph
  2. Crypto Analyst Michaël van de Poppe Says Bitcoin Will Explode By Over 70% Before A ‘Very Fast Black Swan’ Benzinga
  3. This Week in Coins: Bitcoin, Ethereum See First Week of Losses This Year Decrypt
  4. Bitcoin Flashing Conflicting Signals About the Start of the Next Bull Market, According to Two Analytics Firms The Daily Hodl
  5. Michael van de Poppe Predicts Bitcoin Price To Surge More Than 50% – Here’s The Timeline Coinpedia Fintech News
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How Exercise Might Mitigate Age-Related Decline in Skeletal Muscle Structure and Function

Summary: Study reveals exercise is associated with myonuclear remodeling and may contribute to the protective effects of exercise on muscle function throughout the lifespan.

Source: King’s College London

Research has found that exercise is associated with changes to the nucleus in muscle fibres and may contribute to the protective effects of exercise on muscle function throughout the lifespan.

The paper’s authors, from the School of Cardiovascular and Metabolic Medicine & Sciences and the Centre for Human & Applied Physiological Sciences, isolated single muscle fibres from young and older exercise trained individuals.

In particular, they used tissue from young marathon runners and elderly master cyclists – with the latter capable of cycling 100km in under 6.5 hours (with an average age of 76).

Strikingly, they found that myonuclei – commonly referred to as the ‘control centre’ of muscle fibres – were more spherical, less deformable, and contained more of a protein called lamin A than untrained individuals. Parallel studies in mice confirmed changes in lamin A, and showed that myonuclei were stiffer as a result of exercise. 

Writing in the Journal of Physiology, they concluded that exercise is associated with myonuclear remodelling, which is preserved in older people, and may contribute to the protective effects of exercise on muscle function throughout the lifespan.

Age-related decline in skeletal muscle function, such as muscle strength and endurance, can result in reduced quality of life. Whilst it is appreciated that exercise can mitigate the decline in muscle function, the precise mechanisms that control this process are not fully understood.

Characterizing the subcellular changes associated with exercise may therefore improve our understanding of how exercise can extend functionality in old age.

Apart from housing the genome of the cell, the nucleus is capable of sensing and responding to physical forces, which can alter nucleus shape and activate cell communication pathways.

Defects in proteins that control the mechanics of nuclei, such as lamin A, are hallmarks of some diseases including heart disease, muscular dystrophy and premature aging disorders.

In these conditions, nuclei are misshapen and more deformable, with aberrant cell communication. However, whether these particular properties are affected in aging and exercise was previously unknown.

The researchers speculated that nuclei in muscle cells, called myonuclei, would show similar abnormalities to laminopathies in aging individuals. 

Dr Matthew Stroud, Principle Investigator of the Stroud Lab, said: “Whilst we know that exercise is able to overcome various detrimental aspects of the aging process, our molecular understanding of this is incomplete. Here we used both humans and mice to show that changes to nucleus shape and structure in muscle are strongly associated with exercise.”

Age-related decline in skeletal muscle function, such as muscle strength and endurance, can result in reduced quality of life. Image is in the public domain

As gatekeepers of the genome, nuclei govern cell fate and function, and the nuclear alterations we observed may promote muscle adaptation to exercise. This may help to mitigate muscle dysfunction with age.”

Human lifespan has increased substantially over the past half-century and this trend is projected to continue. One concern, however, is that this has not been accompanied by an equivalent extension of healthspan – the part of a person’s life when they are generally in good health – in old age.

Instead of this, morbidity has been extended, and independence and quality of life has reduced. The authors hope that unraveling the beneficial effects of exercise may guide treatments to improve the healthspan of our ever-expanding aging population.

About this exercise, aging, and muscle function research news

Author: Press Office
Source: King’s College London
Contact: Press Office – King’s College London
Image: The image is in the public domain

See also

Original Research: Open access.
“Myonuclear alterations associated with exercise are independent of age in humans” by Matthew Stroud et al. Journal of Physiology


Abstract

Myonuclear alterations associated with exercise are independent of age in humans

Age-related decline in skeletal muscle structure and function can be mitigated by regular exercise. However, the precise mechanisms that govern this are not fully understood. The nucleus plays an active role in translating forces into biochemical signals (mechanotransduction), with nuclear lamina protein

Lamin A regulating nuclear shape, nuclear mechanics, and ultimately gene expression. Defective Lamin A expression causes muscle pathologies and premature ageing syndromes, but the roles of nuclear structure and function in physiological ageing and in exercise adaptations remain obscure.

Here, we isolated single muscle fibres and carried out detailed morphological and functional analyses on myonuclei from young and older exercise-trained individuals.

Strikingly, myonuclei from trained individuals were more spherical, less deformable, and contained a thicker nuclear lamina than untrained individuals. Complementary to this, exercise resulted in increased levels of Lamin A and increased myonuclear stiffness in mice.

We conclude that exercise is associated with myonuclear remodelling, independently of age, which may contribute to the preservative effects of exercise on muscle function throughout the lifespan.

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German pundits see a ripe metaphor in the collapse of this gigantic structure.

Firefighters had already cleared the dead fish from the frigid street by the time I showed up, on Friday morning, outside the smashed front doors of Berlin’s five-star Radisson hotel.

Just hours before, the hotel’s massive AquaDom—billed as the largest freestanding cylindrical aquarium tank in the world—had exploded suddenly, causing a surge of more than a quarter-million gallons of saltwater, along with roughly 1,500 fish, to course through the hotel’s lobby and onto street.

Much of the immediate area—a bustling, tourist-packed hub of broad Communist-era boulevards, shadowed by the red-brick spire of Berlin City Hall—was temporarily closed-off. Bemused tourists and locals gawked from the sidewalk.

Berlin Mayor Franziska Giffey, who described the aquarium’s sudden bursting as “a downright tsunami,” initially declared that none of the marine life survived the disaster.


A diver cleans the glass of the AquaDom in 2010.
Photo by Sean Gallup/Getty Images)

But that turned out to be not completely true: Firefighters discovered a handful of survivors flopping helplessly in puddles among the debris of the elevator and in the lower support ring of the massive aquarium, which had, when not exploded, measured roughly 55 feet high and 38 feet wide. Survivors were hauled to safety in plastic tubs. Hundreds more fish were rescued from separate tanks elsewhere in the complex and sent to the Berlin zoo, private fish breeders, and a nearby aquarium for safe-keeping.

Still, the aquatic carnage was extensive—and the reaction, from the press and citizens alike, was one of shock, coupled with a dose of lamentation and self-recrimination. “The WATER BOOM” screamed the cover of BZ, the city’s leading tabloid, under a photo of mangled remains in the ruined lobby. (Many local newspapers led with photos of a giant dead fish.) The local evening news showed footage of pigeons pecking at chunks on the street.

That the explosion happened in Berlin, often cast as the dysfunctional and mismanaged stepchild to a nation otherwise known for quality engineering, struck many as fitting. Several online pundits were quick to draw parallels between the spectacular aquarium failure and the city’s sparkling embarrassment of a new international airport, which ran billions of dollars over budget, opened a decade late and remains largely a nightmare for travelers.

Der Spiegel ran a column describing the explosion of the aquarium as “the perfect symbol for 2022” and a potent metaphor for the last year in German public life. Germany had, in recent years, appeared to be a marvel of stability, until a crack appeared—created by Russia’s invasion of Ukraine—and, all at once, everything gave way.

“The whole structure, apparently so meticulously constructed, collapsed,” Tobias Rapp, an editor at the magazine, wrote about both the giant hotel aquarium and the social fabric of the nation. “Energy shortages, inflation, geopolitical danger: all the scourges from which Germans falsely believed they were safe had suddenly returned.”

How, you may ask, could this isolated fish fiasco become a metaphor for German failure (at least for some pundits)?

It has been an unsettling year. The country that seemed to coast through crisis after crisis apparently unscathed during the Merkel years has finally faced some major reckonings: a winter without cheap Russian gas, an economy sputtering amid inflation, a major war on the E.U.’s border.

Oh, and the powerhouse German national soccer team sent packing early—again!—at the World Cup.

So something about those poor fish being thrown from their tropical pool seemed of-a-piece with it all. Sandra Weeser, a German member of parliament who happened to be staying in the hotel at the time, told a local newspaper reporter that she awoke to the shockwave of the explosion and the building shaking but fell back asleep thinking it must’ve been a dream. After she woke again an hour later, she passed a large parrot fish—already frozen—on her way out.

The chilly weather, which killed the tropical fish almost instantly, didn’t help. Temperatures overnight had tumbled down to about 15 degrees Fahrenheit, the coldest of the season so far in Berlin (and some 60 degrees colder than the heated saltwater of the tank).

The aquarium, located just across the Spree River from the Berlin Cathedral in the heart of the city, was a genuine attraction for the German capital. A bar ringed the base of the aquarium in the hotel’s lobby, making it a popular and rather spectacular spot to sip a cocktail in a particularly kitschy and touristy part of town. Visitors could pay to take a slow ride on a glass elevator directly through the center of the tank.

In many ways, the timing of the explosion probably limited the scope of the tragedy. Two people—a guest and a hotel employee—were wounded by flying glass. Giffey, the mayor, said the city was lucky the aquarium burst so early in the morning while guests were asleep, the lobby largely vacant and nearby shops still shuttered.




Emergency services outside Berlin’s five-star Radisson hotel after an aquarium exploded inside.
Reuters

Even hours later, a fire department spokesman told me that the debris from the explosion was too thick for firefighters to work through the wreckage in the lobby. Instead, search and rescue dogs from the Red Cross were brought in to make sure no one was trapped inside.

By Monday morning, the immediate cleanup was mostly complete, although the building itself remained an off-limits disaster zone surrounded by construction fencing. Shops in the building, including a Lindt chocolate outlet and a gift shop peddling tchotchkes festooned with Berlin’s iconic Ampelmännchen traffic-light figures, remained indefinitely closed. Shuttered, too, was the DDR Museum located beneath the hotel, devoted to depicting daily life in the defunct communist German Democratic Republic.

Will the great AquaDom be rebuilt? Unclear. A spokesman for the property owner, Union Investment, told local media that they’re still assessing what to do with the space once the clean-up is over.

Some voices in Berlin are already calling for its return. Ephraim Gothe, a Berlin city councilman who represents the area, told the Berliner Morgenpost that the AquaDom was an attraction of worldwide renown and importance. Unsurprisingly, PETA had already come out swinging against rebuilding it. The organization has threatened legal action and called for a monument to be erected in memory of the dead fish.

But could it ever be the same? A central part of the novelty and attraction of sitting beneath the aquarium was staring in slack-jawed wonder that the entire monstrosity didn’t explode, that the plexiglass walls managed to hold against the weight and pressure of all that water – and wondering just what might happened if even the smallest crack appeared and began to grow.

Back then, back before the entire thing suddenly erupted in a spectacular mess, you could take another sip of your drink and assure yourself that a whole team of eminently qualified experts had created this marvel of modern engineering. And that engineering was German.



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‘Ghostly glow’ in the solar system could be ‘new addition’ to our understanding of its structure

‘Ghostly glow’ in the solar system could be ‘new addition’ to our understanding of its structure – but the source remains a mystery

  • NASA’s Hubble telescope has discovered a glow surrounding the solar system 
  • Scientists are baffled by this glow that is equivalent to 10 fireflies
  • The team theorizes it could be dust from comets that fall into the solar system 

A mysterious ‘ghostly glow’ equivalent to 10 fireflies has been found around our solar system that persists even when other light sources like stars and planets are subtracted.

The discovery was made when astronomers set out to see just how dark space can be, which they did by sifting through 200,000 images snapped by NASA’s Hubble Space Telescope and eliminating the expected glow – but a tiny excess of light prevailed.

Scientists cannot be sure where the light is coming from but hypothesize the source is a previously unknown sphere made up of dust from comets, which is reflecting sunlight.

If confirmed, researchers said this dust shell would be a new addition to the known architecture of the solar system. 

Scientists have discovered a ‘ghostly glow’ surrounds our solar system while analyzing pictures snapped by NASA’s Hubble telescope 

This discovery builds on research conducted in 2021 when another group of astronomers used data from NASA’s interplanetary space probe New Horizon to measure the sky background. 

New Horizon also detected a glow around the solar system, but the probe was more than four billion miles from the sun, and what caused it remains a mystery to this day.

Numerous theories range from the decay of dark matter to a huge unseen population of remote galaxies.

Tim Carleton of Arizona State University (ASU) said in a statement: ‘If our analysis is correct, there’s another dust component between us and the distance where New Horizons made measurements.

The team was measuring the darkness of the sky, in which they needed to subtract the zodiacal light, which is the glow given off by stars planets

‘That means this is some kind of extra light coming from inside our solar system.’

Carleton continued to explain that since the light appeared faint in New Horizons’ data due to its distance, the glow must be coming from within the limits of the solar system.

‘It may be a new element to the contents of the solar system that has been hypothesized but not quantitatively measured until now,’ he said.

This led the recent work to use Hubble, which sits about 340 miles above Earth’s surface.

Hubble veteran astronomer Rogier Windhorst, also of ASU, said in a statement: ‘More than 95 percent of the photons in the images from Hubble’s archive come from distances less than 3 billion miles from Earth. 

‘Since Hubble’s very early days, most Hubble users have discarded these sky-photons, as they are interested in the faint discrete objects in Hubble’s images such as stars and galaxies.

Hubble (pictured) captured the glow as it around 340 miles above Earth’s surface. Astronomers who analyzed the images suggest the glow could come from a dust sphere made of comets 

‘But these sky-photons contain important information which can be extracted thanks to Hubble’s unique ability to measure faint brightness levels to high precision over its three decades of lifetime.’

Hubble, a joint project of NASA, the European Space Agency and the Canadian Space Agency, has been observing the universe for over three decades.

It has taken more than 1.5 million observations of the universe, and over 18,000 scientific papers have been published based on its data.

The telescope orbits Earth at a speed of about 17,000mph in low Earth orbit at about 340 miles in altitude, slightly higher than the International Space Station.

Launched in April 1990 from the Kennedy Space Center in Florida, Hubble is showing more and more signs of aging, despite a series of repairs and updates by spacewalking astronauts during NASA’s shuttle era.

The telescope is named after famed astronomer Edwin Hubble who was born in Missouri in 1889 and discovered that the universe is expanding, as well as the rate at which it is doing so.

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Chris Christensen death: Man who died at parking structure in Anaheim identified as Newland Elementary School principal

According to police, it’s unknown if he jumped or fell from a parking structure in Anaheim, but police believe he died by suicide.

ANAHEIM, Calif. (KABC) — A Southern California school district is mourning the tragic loss of a beloved principal.

The Fountain Valley School District said Chris Christensen, a principal at Newland Elementary School in Huntington Beach, died on Saturday.

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“Mr. Christensen has been a respected leader in FVSD for over 20 years,” read a statement issued by the district. “His contributions and connections to this community are immeasurable. He was a father, husband, brother, and friend to so many. His passing leaves us devastated and heartbroken.”

According to police, it is not known if he jumped or fell from a parking structure in Anaheim, but police suspect he died by suicide.

Christensen, who was in his 50s, was scheduled to appear in court on Monday after he was recently charged with misdemeanor counts of child endangerment and battery. He pleaded not guilty to both crimes.

According to FVSD, grief counselors will be available at all schools to help students, staff and their families.

“I too am struggling to find adequate words to convey the shock and heartbreak we are all feeling right now,” said FVSD Superintendent Katherine Stopp in the district’s statement. “I know that we will find a way to come together as a community and care for one another. Let us all show patience to each other as we work through this time in the next days and weeks.”

If you or someone you know is struggling with suicidal thoughts or mental health matters, please call the National Suicide Prevention Lifeline at 800-273-8255 (or just by dialing 988) to connect with a trained counselor or visit the NSPL site.

New suicide hotline 988 provides counseling for mental health emergencies

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