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Scientists discover a new virus lurking in bats: Similar pathogens kill up to one in three humans

Scientists have discovered a new virus lurking in bats.

The Kiwira virus — a type of hantavirus — has been found in free-tailed bats in Tanzania and the Democratic Republic of the Congo.

There is currently no evidence to show that Kiwira virus could pose a threat to humans but researchers are conducting follow-up studies.

Hantaviruses are usually found in rodents and spread to humans through contact with infected animals, with a disease the virus can cause killing up to a third of those it infects.

The group of viruses can trigger mild flu-like illness symptoms but also excessive bleeding and kidney failure.

It comes after MPs warned last week that Britain’s biggest animal disease facility — responsible for monitoring animal-borne infections — has been left to crumble. 

The Kiwira virus – a type of hantavirus – has been found in free-tailed bats in Tanzania and the Democratic Republic of the Congo

There is currently no evidence to show the virus could pose a threat to humans but researchers are conducting follow-up studies. Map shows where virus has been detected (crosses) and the regions the free-tailed bats inhabit (blue area)

Detailing the new virus in the journal Viruses, the researchers, led by Dr Sabrina Weiss, head of public health at the Centre for International Health Protection in Berlin, noted that free-tailed bats cover ‘large regions’ of Sub-Saharan Africa.

And the species is known to roost ‘inside and around human dwellings’, so a ‘potential spillover of the Kiwira virus to humans must be considered’, they warned.

Research is to be carried out among bats in the area to better understand their make up and whether it is possible for the virus to spread to humans. 

While no cases have been spotted in people so far, the researchers said hantavirus often triggers general fever-like symptoms so may be hard to spot. 

How the disease can affect humans depends on what type of hantavirus it is.    

Sin Nombre virus — a hantavirus spread by deer mice in the USA — can trigger a syndrome that kills up to one in three humans, whereas Puumala virus — commonly associated with bank moles — has a mortality rate of less than one in 200.

There is currently not much evidence to suggest the Kiwira virus poses a significant problem to bats either, with just six out of 334 bats from Tanzania and one out of 49 bats from DRC found to be carrying the disease. 

However researchers said: ‘Hantavirus disease often manifests as a febrile illness with non-specific symptoms […] and might be easily overlooked.’

The viruses are primarily spread to humans through contact with an infected animal’s urine, faeces and saliva. However, in rare cases, the viruses can spread between humans.

Chelsea Wood, an assistant professor of parasite ecology at the University of Washington, spoke of the risks in National Geographic. 

There is currently not much evidence to suggest the Kiwira virus poses a significant problem to bats either, with just six out of 334 bats from Tanzania and one out of 49 bats from DRC found to be carrying the disease

She said: ‘The scary thing about these zoonotic viruses is that the spillover process is happening all the time. Covid is a great example.’

It comes after it was revealed that the Animal and Plant Health Agency’s (APHA) headquarters — the site tasked with stopping animal-borne infections in their tracks — was found to have been ‘left to deteriorate to an alarming extent’.

Parliament’s Public Accounts Committee warned the APHA site, near Weybridge, Surrey, would cost up to £3billion to fix it over the next 15 years.

That is despite the Covid pandemic showing how easily an animal-sourced virus can plunge the world into chaos. 

APHA’s Weybridge site is the UK’s primary science facility for managing threats from animal diseases. 

Dame Meg Hillier MP, chairwoman of the Public Accounts Committee, said: ‘These diseases are devastating for our food production systems, the economy and, when they jump the species barrier to humans as Covid did, to our whole society.’ 

APHA’s Weybridge site is the UK’s primary science facility for managing threats from animal disease but the Environment Department (Defra) has ‘comprehensively failed in its historical management’ of the complex

In June, the World Health Organisation (WHO) released a report on Covid, saying bats most likely transferred the virus to humans. 

The new report, called Scientific Advisory Group for the Origins of Novel Pathogens (SAGO), said a zoonotic origin was the most likely explanation for the emergence of the novel coronavirus. 

The first human cases were reported in December 2019 in the central Chinese city of Wuhan.

However, the report said that neither the original animal source, the intermediate host, nor the moment the virus crossed over into humans, has been identified.

That is chiefly because a lot of data is missing, the report said, particularly from China. 

ZOONOTIC DISEASES: THESE ARE VIRUSES USUALLY STARTED IN WILD ANIMALS THAT CAN PASS TO OTHER SPECIES AND SURVIVE

Zoonotic diseases are able to pass from one species to another.

The infecting agent – called a pathogen – in these diseases is able to cross the species border and still survive. 

They range in potency, and are often less dangerous in one species than they are in another. 

In order to be successful they rely on long and direct contact with different animals.  

Common examples are the strains of influenza that have adapted to survive in humans from various different host animals. 

H5N1, H7N9 and H5N6 are all strains of avian influenza which originated in birds and infected humans.

These cases are rare but outbreaks do occur when a person has prolonged, direct exposure with infected animals. 

The flu strain is also incapable of passing from human to human once a person is infected.  

A 2009 outbreak of swine flu – H1N1 – was considered a pandemic and governments spent millions developing ‘tamiflu’ to stop the spread of the disease. 

Influenza is zoonotic because, as a virus, it can rapidly evolve and change its shape and structure.  

There are examples of other zoonotic diseases, such as chlamydia. 

Chlamydia is a bacteria that has many different strains in the general family. 

This has been known to happen with some specific strains, Chlamydia abortus for example.

This specific bacteria can cause abortion in small ruminants, and if transmitted to a human can result in abortions, premature births and life-threatening illnesses in pregnant women.

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Apple iPhone 15 might have 8GB RAM, similar to Samsung Galaxy S23

Be it RAM, storage space, screen resolution, or battery capacity, Samsung’s Galaxy S phones have always offered better hardware specifications than competing iPhones. However, with the rising importance of software optimization, the South Korean firm is moving its focus away from hardware specs. Now, Apple is catching up, and its next-generation iPhones might offer as much RAM as the Galaxy S23.

According to a new report from Taiwanese research firm TrendForce, Apple might equip the iPhone 15 Pro and the iPhone 15 Pro Max models with 8GB of RAM. That’s 2GB more than current-generation iPhones and as much RAM as the Galaxy S23 and the Galaxy S23+. 2023 will be the first time Samsung’s competing high-end phone (Galaxy S23+) will have as much RAM as its competing iPhone model (iPhone 15 Pro).

And that’s not the only aspect where the iPhone 15 series will match the Galaxy S23. The report also claims that the iPhone 15 Pro Max will feature a 10x optical zoom camera with a periscope lens, similar to the Galaxy S23 Ultra. With the EU mandate, Apple is forced to offer a USB Type-C port with its next-generation iPhones.

iPhones are usually better than Galaxy phones in video recording, especially in low-light conditions, but the Galaxy S23 Ultra is expected to bring massive improvements. With similar RAM, storage, camera zoom, and video recording capabilities, the competition between the Galaxy S23 series and the iPhone 15 lineup will be fiercer than ever. And it could all come down to the quality of software optimization.

What are your thoughts on the importance of hardware specs? Let us know in the comments section below.

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Autumn COVID variants look shockingly similar and powerful for these 2 reasons

Earlier this year, fears of a new “super strain” of Omicron were real—and rising.

A researcher in Cyprus identified a COVID-19 variant that had features of both the deadly Delta and the highly transmissible, immune-evasive Omicron variants. “Deltacron,” as the new variant became known, was a bit of a “frankenvirus” that combined the two strains.

Deltacron failed to take off, and it soon disappeared. A second Delta-Omicron hybrid later arose then also subsided.

But the phenomenon that caused it is likely to come into play this fall. Scientists expect a sizable wave of COVID cases October through January, fueled by multiple Omicron spinoffs that look increasingly alike—both to each other and to older versions of the scourge.

They’re expected to be the most immune-evasive, transmissible versions of the virus yet. Their similarity could be a blessing or curse: It could make them easier to fight—or harder to control.

As Omicron evolves, it’s “rediscovering solutions that have been used before” in variants like Alpha, Gamma, and Delta “while bringing some new things along with its lineage,” Dr. Stuart Ray, vice chair of medicine for data integrity and analytics at Johns Hopkins Department of Medicine, told Fortune.

“It’s a fascinating part of evolution,” he said. “We see the same scraps of cloth being used to make a new quilt.”

Different paths, same goal

While a fall wave of COVID may be fueled by multiple variants—as many as five or more—the differences between them could be minor, Dr. Raj Rajnarayanan, assistant dean of research and associate professor at the New York Institute of Technology campus in Jonesboro, Ark., told Fortune.

In a form of parallel evolution called convergent evolution, variants are collecting identical sets of concerning mutations. In other words, multiple strains of the same virus are picking up similar mutations, like ones that will help them evade immunity and make it easier for the virus to spread, according to Rajnarayanan.

One example: The wave of globally dominant BA.5 is beginning to recede in many locations—but its spin-offs are picking up mutations that promote immune evasion, Dr. Michael Osterholm, director of the University of Minnesota’s Center for Infectious Disease Research and Policy (CIDRAP), told Fortune.

“We’ve not seen this type of immune evasion before,” he said, speaking of the variants’ increasing ability to dodge the immune system and tools that bolster it, like vaccines and treatments.

Meanwhile, COVID strains are also mutating through a process called recombination—the same strategy the so-called Deltacron strain used. In this scenario, two variants meld into one. Case in point: new variant XBB, a merger of two different Omicron spawns that is the most immune-evasive COVID strain seen yet, according to Rajnarayanan.

Unlike the initial Deltacron—which was only identified in a single lab, signaling that it may have been a product of lab contamination—XBB is being found worldwide in places like Bangladesh, Israel, Singapore, Germany, and Denmark, he said.

With all the mixing and matching of Omicron spawn occurring this fall, will the resulting muddled mess constitute some kind of “super virus”?

It’s impossible to know, experts say. But Omicron may be close to reaching a “local fitness peak,” meaning the variant—while still evolving quickly—might soon be unable to spread or evade human immune systems any better than their predecessors.

“I do wonder if it’s running out of options,” Ray said of Omicron. “It doesn’t mean it’s reached the peak of spread, but it may put some bounds on it.”

A new foe this winter?

If Omicron is indeed peaking in terms of performance, it could pave the way for the entrance of a completely new variant, like Delta, which arrived in the U.S. in the summer of 2021, and Omicron, which hit several months later.

“Somewhere there might be a Pi lurking that has a new set of solutions,” Ray said, referring to the possibility of another major variant along the lines of Alpha, Beta, Gamma, Delta, and Omicron. “If the virus runs out of space for advantageous changes, a new variant might emerge that changes the calculus for all of us.”

He continued: “It’s been a while since we’ve seen a big new variant come out of left field. But I think it’s reasonable to believe it’s going to happen this winter. It’s just nothing anyone can predict.”

Osterholm agrees that the world “could be in a situation where Pi or Sigma show up.”

“None of us know—that’s the challenge right now,” he said. “We just have to be very humble and say we don’t know what the next shoe to drop is.”

It’s also possible that “we begin to see what I call a ‘soft landing,’” a gradual lowering in the number of cases, he added.

Osterholm sees no evidence, however, that COVID is turning into a seasonal virus like the flu and that one vaccine a year will suffice, like some White House officials recently suggested.

The virus, he says, is a “three act play.”

“I think we’re only in the second act,” he said. “That’s the problem.”

This story was originally featured on Fortune.com

.

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Autumn COVID variants look shockingly similar and powerful for these 2 reasons

Earlier this year, fears of a new “super strain” of Omicron were real—and rising.

A researcher in Cyprus identified a COVID-19 variant that had features of both the deadly Delta and the highly transmissible, immune-evasive Omicron variants. “Deltacron,” as the new variant became known, was a bit of a “frankenvirus” that combined the two strains.

Deltacron failed to take off, and it soon disappeared. A second Delta-Omicron hybrid later arose then also subsided. 

But the phenomenon that caused it is likely to come into play this fall. Scientists expect a sizable wave of COVID cases October through January, fueled by multiple Omicron spinoffs that look increasingly alike—both to each other and to older versions of the scourge.

They’re expected to be the most immune-evasive, transmissible versions of the virus yet. Their similarity could be a blessing or curse: It could make them easier to fight—or harder to control.

As Omicron evolves, it’s “rediscovering solutions that have been used before” in variants like Alpha, Gamma, and Delta “while bringing some new things along with its lineage,” Dr. Stuart Ray, vice chair of medicine for data integrity and analytics at Johns Hopkins Department of Medicine, told Fortune.

“It’s a fascinating part of evolution,” he said. “We see the same scraps of cloth being used to make a new quilt.”

Different paths, same goal

While a fall wave of COVID may be fueled by multiple variants—as many as five or more—the differences between them could be minor, Dr. Raj Rajnarayanan, assistant dean of research and associate professor at the New York Institute of Technology campus in Jonesboro, Ark., told Fortune.

In a form of parallel evolution called convergent evolution, variants are collecting identical sets of concerning mutations. In other words, multiple strains of the same virus are picking up similar mutations, like ones that will help them evade immunity and make it easier for the virus to spread, according to Rajnarayanan.

One example: The wave of globally dominant BA.5 is beginning to recede in many locations—but its spin-offs are picking up mutations that promote immune evasion, Dr. Michael Osterholm, director of the University of Minnesota’s Center for Infectious Disease Research and Policy (CIDRAP), told Fortune.

“We’ve not seen this type of immune evasion before,” he said, speaking of the variants’ increasing ability to dodge the immune system and tools that bolster it, like vaccines and treatments.

Meanwhile, COVID strains are also mutating through a process called recombination—the same strategy the so-called Deltacron strain used. In this scenario, two variants meld into one. Case in point: new variant XBB, a merger of two different Omicron spawns that is the most immune-evasive COVID strain seen yet, according to Rajnarayanan.

Unlike the initial Deltacron—which was only identified in a single lab, signaling that it may have been a product of lab contamination—XBB is being found worldwide in places like Bangladesh, Israel, Singapore, Germany, and Denmark, he said.

With all the mixing and matching of Omicron spawn occurring this fall, will the resulting muddled mess constitute some kind of “super virus”?

It’s impossible to know, experts say. But Omicron may be close to reaching a “local fitness peak,” meaning the variant—while still evolving quickly—might soon be unable to spread or evade human immune systems any better than their predecessors. 

“I do wonder if it’s running out of options,” Ray said of Omicron. “It doesn’t mean it’s reached the peak of spread, but it may put some bounds on it.”

A new foe this winter?

If Omicron is indeed peaking in terms of performance, it could pave the way for the entrance of a completely new variant, like Delta, which arrived in the U.S. in the summer of 2021, and Omicron, which hit several months later.

“Somewhere there might be a Pi lurking that has a new set of solutions,” Ray said, referring to the possibility of another major variant along the lines of Alpha, Beta, Gamma, Delta, and Omicron. “If the virus runs out of space for advantageous changes, a new variant might emerge that changes the calculus for all of us.”

He continued: “It’s been a while since we’ve seen a big new variant come out of left field. But I think it’s reasonable to believe it’s going to happen this winter. It’s just nothing anyone can predict.”

Osterholm agrees that the world “could be in a situation where Pi or Sigma show up.”

“None of us know—that’s the challenge right now,” he said. “We just have to be very humble and say we don’t know what the next shoe to drop is.”

It’s also possible that “we begin to see what I call a ‘soft landing,’” a gradual lowering in the number of cases, he added.

Osterholm sees no evidence, however, that COVID is turning into a seasonal virus like the flu and that one vaccine a year will suffice, like some White House officials recently suggested.

The virus, he says, is a “three act play.”

“I think we’re only in the second act,” he said. “That’s the problem.”

Read original article here

People With Similar Faces Likely Have Similar DNA

Summary: People who look alike but are not related share similar DNA, a new study reports. The findings also suggest the shared genetic variations not only relate to similar physical appearance but also common habits and behaviors.

Source: Cell Press

A collection of photos of genetically unrelated look-alikes, along with DNA analysis, revealed that strong facial similarity is associated with shared genetic variants.

The work appears August 23 in the journal Cell Reports.

“Our study provides a rare insight into human likeness by showing that people with extreme look-alike faces share common genotypes, whereas they are discordant at the epigenome and microbiome levels,” says senior author Manel Esteller of the Josep Carreras Leukemia Research Institute in Barcelona, Spain. “Genomics clusters them together, and the rest sets them apart.”

The number of people identified online as virtual twins or doubles who are genetically unrelated has increased due to the expansion of the World Wide Web and the possibility of exchanging pictures of humans across the planet. In the new study, Esteller and his team set out to characterize, on a molecular level, random human beings that objectively share facial features.

To do so, they recruited human doubles from the photographic work of François Brunelle, a Canadian artist who has been obtaining worldwide pictures of look-alikes since 1999. They obtained headshot pictures of 32 look-alike couples. The researchers determined an objective measure of likeness for the pairs using three different facial recognition algorithms.

In addition, the participants completed a comprehensive biometric and lifestyle questionnaire and provided saliva DNA for multiomics analysis. “This unique set of samples has allowed us to study how genomics, epigenomics, and microbiomics can contribute to human resemblance,” Esteller says.

Overall, the results revealed that these individuals share similar genotypes, but differ in their DNA methylation and microbiome landscapes. Half of the look-alike pairs were clustered together by all three algorithms. Genetic analysis revealed that 9 of these 16 pairs clustered together, based on 19,277 common single-nucleotide polymorphisms.

Photographic examples of look-alikes used in this study. Credit: François Brunelle

Moreover, physical traits such as weight and height, as well as behavioral traits such as smoking and education, were correlated in look-alike pairs. Taken together, the results suggest that shared genetic variation not only relates to similar physical appearance, but may also influence common habits and behavior.

“We provided a unique insight into the molecular characteristics that potentially influence the construction of the human face,” Esteller says.

“We suggest that these same determinants correlate with both physical and behavioral attributes that constitute human beings.”

A few study limitations include the small sample size, the use of 2D black-and-white images, and the predominance of European participants. Despite these caveats, the findings may provide a molecular basis for future applications in various fields such as biomedicine, evolution, and forensics.

“These results will have future implications in forensic medicine—reconstructing the criminal’s face from DNA—and in genetic diagnosis—the photo of the patient’s face will already give you clues as to which genome he or she has,” Esteller says.

“Through collaborative efforts, the ultimate challenge would be to predict the human face structure based on the individual’s multiomics landscape.”

About this genetics research news

Author: Press Office
Source: Cell Press
Contact: Press Office – Cell Press
Image: The image is credited to François Brunelle

See also

Original Research: Open access.
“Look-alike humans identified by facial recognition algorithms show genetic similarities” by François Brunelle et al. Cell Reports


Abstract

Look-alike humans identified by facial recognition algorithms show genetic similarities

Highlights

  • Facial recognition algorithms identify “look-alike” humans for multiomics studies
  • Intrapair look-alikes share common genetic sequences such as face trait variants
  • DNA methylation and microbiome profiles only contribute modestly to human likeness
  • The identified SNPs impact physical and behavioral phenotypes beyond facial features

Summary

The human face is one of the most visible features of our unique identity as individuals. Interestingly, monozygotic twins share almost identical facial traits and the same DNA sequence but could exhibit differences in other biometrical parameters.

The expansion of the world wide web and the possibility to exchange pictures of humans across the planet has increased the number of people identified online as virtual twins or doubles that are not family related.

Herein, we have characterized in detail a set of “look-alike” humans, defined by facial recognition algorithms, for their multiomics landscape. We report that these individuals share similar genotypes and differ in their DNA methylation and microbiome landscape.

These results not only provide insights about the genetics that determine our face but also might have implications for the establishment of other human anthropometric properties and even personality characteristics.

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Beyoncé Officially Removes Kelis’ Sample Off Renaissance Album; Monica Lewinsky Calls for Similar Move in 2013 Song

Beyoncé attends the premiere of Disney’s “The Lion King” at Dolby Theatre on July 09, 2019 in Hollywood, California.
Photo: Kevin Winter (Getty Images)

Update as of 8/4/2022 at 10:30a.m.ET: Kelis has responded to the interpolation of her hit song “Milkshake” being taken off of Beyonce’s Renaissance album. Thanks to fans who began comment creeping on Instagram, Kelis is apparently very grateful for the removal but she’s not moved by it.

“You happy Beyonce took that sample off, cry baby?,” one Instagram user asked according to Hollywood Unlocked. Kelis responded: “Yes I am actually, lol nobody cried.”

When another user said: “TBH, I would have just been happy to be on the album,” Kelis wrote: “And that’s why you are you and thank God I am me lol.”

The original story follows below.

Last week, we told you about how “Bossy” singer Kelis called out Beyoncé and former music manager Pharrell Williams for interpolating her 2003 hit song “Milkshake” on Bey’s newly-released Renaissance album without her knowledge. Now, it appears all that hubbub was for nothing as Beyoncé has taken the usage of the song off the album in its entirety.

Per Billboard, the usage of the song appeared on the fifth song on the album, “Energy,” and has now been removed on both Tidal and Apple Music. Subsequently, the move was met with much fanfare online, with many applauding the “Black Parade” singer for removing it outright so as not to further feed into any drama.

Of course, this isn’t the first time Queen Bey has post-audited the album since its release last Friday. As previously reported by The Root, after receiving backlash for her song “Heated —which featured the word “spaz” and was quickly met with disdain from disability advocates who claimed the lyrics were “offensive and ableist,”—the multi-Grammy-winning artist later confirmed in a statement that it would be replaced.

And while those in the community raised a valid point, someone else decided to hop on the bandwagon in an attempt to get Bey to remove or change lyrics from a different song she put out nearly 10 years ago. As EW notes, on Tuesday, Monica Lewisnky (yes, that Monica Lewinksy) sent out a tweet that seemingly suggested that she wanted her name replaced in Beyonce’s 2013 hit song “Partition.”

The particular line in the song, Bey is referring to a man who “Monica Lewisnky’d all on my gown.” However, folks online were quick to call out her hypocrisy, noting that she has “rap song muse” in her Twitter bio while others cited a 2014 Vanity Fair article she wrote in which she thanked Beyoncé for including her on the song but quipped about how it was used incorrectly.

“Miley Cyrus references me in her twerking stage act, Eminem raps about me, and Beyoncé’s latest hit gives me a shout-out. Thanks, Beyoncé,” an excerpt from the article read. “But if we’re verbing, I think you meant ‘Bill Clinton’d all on my gown,’ not ‘Monica Lewinsky’d.’”

She later clarified that in that moment, she was using humor to deal with “painful or humiliating things” as she often does, and that she had not “directly” reached out to Beyoncé’s camp to have the lyrics officially changed.

Monica aside though, if artists are going to start editing their albums due to some people’s disdain of them, whether warranted or not, they have to be very careful of the slippery slope they may end up embarking on if this becomes precedent. Any person, brand, or entity could then cause an uproar all in an attempt to get lyrics changed and I shouldn’t have to tell you how dangerously close that comes to censorship if that kind of thinking and action gets enacted by the wrong party.

What do you think? Should Beyoncé have removed Kelis’ sample? Should she change her 2013 lyrics and edit out Monica’s name? Let’s chat about it in the comments!



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We Lose One Crucial Feature of Consciousness While We Sleep, an 8-Year Study Reveals

When we dream, something mysterious happens within our brains – we experience something similar to being awake, and yet also very different to being awake, and scientists are still trying to unpick exactly what’s going on in that in-between state.

 

Now another clue has been discovered. A new study has found that one crucial feature of consciousness – the ability to be aware of sounds or to identify them – actually gets switched off while we’re asleep, and it could help us figure out how our brains dream.

Mapping the brains of living people while both awake and asleep isn’t easy – few of us would want electrodes implanted in our skulls during our day-to-day activities – but here the team took advantage of medical research being carried out on epilepsy patients.

“We were able to utilize a special medical procedure in which electrodes were implanted in the brains of epilepsy patients, monitoring activity in different parts of their brain for purposes of diagnosis and treatment,” says neuroscientist Yuval Nir, from Tel Aviv University in Israel.

“The patients volunteered to help examine the brain’s response to auditory stimulation in wakefulness versus sleep.”

The electrodes enabled the researchers to see the differences in the response of the cerebral cortex when patients were in different stages of sleep compared to when they were awake – right down to individual neurons.

 

For the purposes of the study, the researchers played a variety of sounds through speakers at the bedsides of the volunteers. Data on over 700 neurons (about 50 per patient) were collected across the course of eight years.

While the brain’s response to sound remained largely switched on during sleep, there was a rise in the level of alpha-beta waves – waves associated with attention and expectation. It seems incoming sounds are being analyzed, but not passed to the consciousness.

This goes against previous thinking: that during sleep, sound-related signals quickly decay in the brain. In fact, they stay stronger and richer than we thought, it’s just that there’s one significant difference in the way they’re processed while we’re snoozing.

“The strength of brain response during sleep was similar to the response observed during wakefulness, in all but one specific feature, where a dramatic difference was recorded: the level of activity of alpha-beta waves,” says first author, neuroscientist Hanna Hayat, from Tel Aviv University.

These alpha-beta waves (10-30Hz) are controlled by feedback from higher up in the brain – this feedback (including whether or not sounds are new) helps our minds work out which sounds are important and need to be listened to.

A similar sort of upward shift in alpha-beta wave patterns has previously been observed in patients under anesthetic, but it hasn’t been seen in people sleeping. The researchers describe it as one way of grasping the “fascinating enigma” of how the conscious brain differs from the unconscious brain.

This also gives scientists a quantitative and reliable method of measuring if someone really is unconscious or not: during hospital operations, in comatose individuals, when checking for signs of dementia, and so on.

“Our findings have wide implications beyond this specific experiment,” says Nir. “In future research we intend to further explore the mechanisms responsible for this difference.”

The research has been published in Nature Neuroscience.

 

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The Similar Stories Of COVID Long-Haulers And Chronic Lyme Sufferers

Ask Rebecca Niziol, 34, about life before Lyme, and she remembers bounding around with infinite energy. A life coach and yoga instructor, she packed her schedule with hikes, Pilates workouts, client calls, meet-ups with friends, and weekend getaways. Then, in July 2020, she felt something change.

It started with neck pain and headaches. At first, she brushed them off as side effects of sitting in a car for hours on a road trip from Chicago to Colorado to visit family. Over the next few weeks, though, she continued to develop flu-like symptoms. It was the early months of the pandemic, so her immediate thought was COVID. But tests kept coming back negative.

She couldn’t practice yoga for a month. “I was in bed 20 hours a day,” she says. Her doctor suspected loneliness and pandemic-related anxiety, but her gut told her this was different. Something more physical, never-ending. She wouldn’t learn that she was battling Lyme disease for more than a year, when she connected with a “Lyme-literate” doctor and her labs confirmed it.

Brittany Barry, of Utah, faced a similarly confusing crisis last summer. Given that she was a self-described “healthy, fit, 32-year-old woman” at the time, doctors chalked up the muscle aches, fatigue, and shortness of breath to long COVID—a term for the phenom of health problems continuing long after someone tests positive for the virus. (She had COVID in February 2021.) One MD blamed post-pregnancy changes, while another told her to see a counselor.

Fast-forward to January 2022, when she found a doctor who did blood work that pointed to Lyme that had likely gone undetected for years.

Getty

Parallel Experiences

A coincidence that these women’s diagnoses came when they did? Maybe. But just like Niziol and Barry, many who’ve been impacted by long COVID, Lyme, or even both in the past few years are realizing they’re telling a similar story. There’s been a shift in empathy for chronic-illness and autoimmune patients who are stuck in a cycle of nonspecific symptoms that medical experts don’t totally know what to do with, says Niziol, who is still managing Lyme today.

Despite many yet-to-be-solved mysteries (we’ll get into those!), physicians and patients alike can agree the suffering is real—as is the serious change in perspective, says Robert Kalish, MD, a rheumatologist and the director of the Lyme Disease Clinic at Tufts Medical Center. “The pandemic helped people grasp the idea that you can get an infection, kill the initial cause, and still suffer lasting consequences from damage that’s been done—even if it’s difficult to detect or understand,” he says.

Up to 20 percent of Lyme patients report that their symptoms come back or never truly go away.

When you’re sick, you crave validation. Recognition gives you a better chance at care, not to mention dignifies your reality. “There’s a lot of similarity in experience between long-haulers and folks with chronic illnesses like mine being misunderstood or misdiagnosed,” Niziol says. “I might not have what you have, but I relate and deeply empathize.”

Diagnosis Dilemma

More compassion is huge. But it doesn’t erase the fact that Lyme is the most common tick-borne infection in the U.S., with an estimated 476,000 new cases each year (although only an estimated 35,000 get reported annually because of how difficult it is to diagnose). Since 1991, the prevalence of Lyme has nearly doubled as deer ticks, the main carriers of the disease, have expanded their territory. What’s more, increasing temps are expected to up Lyme cases by more than 20 percent between 2036 and 2065, a recent study found.

So, yes, a very real and growing threat, yet Lyme has been steeped in controversy pretty much since it was discovered in the ’70s. For one thing, there’s no perfect test: False negatives and positives happen often, which makes getting a correct diagnosis a challenge. Not every positive person shows the one telltale symptom—a bull’s-eye–shaped rash—either. (Niziol and Barry have no recollection of one.)

Further complicating the path to an accurate diagnosis is that Lyme, nicknamed “the great imitator,” can look like a bunch of other conditions, such as multiple sclerosis, depression, fibromyalgia, or a general viral infection. Niziol faced multiple misdiagnoses as her symptoms escalated to brain fog, blurry vision, bouts of numbness in limbs, and gaps in memory, as the months rolled on without answers. “I felt like a shell of a human,” she says. “My vibrancy was gone; joy left my body.”

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Long-Haul Life

If and when you get a definitive read? The fight doesn’t necessarily stop there. With speedy detection and treatment (typically a four-week or longer course of antibiotics), the infection is usually easy to resolve at first. But for many, including Niziol, symptoms live on.

In August 2021, just over a year after her symptoms first emerged, and still desperate to find a doctor who really understood, she searched online for specialists in her area. This time, she visited Casey Kelley, MD, a family and integrative medicine physician. Dr. Kelley ran a slew of tests and diagnosed Niziol with chronic Lyme. (Just when you thought things couldn’t get trickier!)

The diagnosis most commonly given is post-treatment Lyme disease syndrome, or PTLDS. But some doctors go so far as to use the term “chronic Lyme disease,” though this is not a diagnosis recognized by the National Institutes of Health. That’s because in one camp, you have pros who question the legitimacy of this term that indicates an ongoing infection, citing human studies that show meds are effective in killing bacteria that cause Lyme. On the other side are docs like Dr. Kelley who believe chronic Lyme is real even if it’s unclear why it happens. (She points to studies that suggest a long-term infection remains.)

Whatever you call it, “This much is not controversial: There’s no proven effective treatment for persistent Lyme,” says Linden Hu, MD, a professor of immunology at Tufts University School of Medicine. Depending on your doctor, solutions could involve meds, supplements, and/or an anti-inflammatory diet. “A two-steps-forward, one-slide-back kind of situation,” Niziol says.

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Health On The Horizon

The reassuring news is that real advancement is underway. In the past few years, tens of millions of dollars have been dedicated to combating Lyme. Researchers at Columbia University are working on brain imaging studies to better understand symptoms like chronic fatigue and pain that come with the infection.

Game-changing innovations to defeat the disease are also in the pipeline. A vaccine being tested in guinea pigs (thank you, Yale researchers) triggers an immune reaction to a tick bite that helps get the bug to detach, inhibits its ability to feed from you, and reduces transmission of the pathogen. Another candidate, from Valneva and Pfizer, works by killing bacteria in the bloodsuckers. Early studies indicate the prick is safe, and you might be able to get it as soon as 2025.

Researchers at Tufts University also set the lofty goal of eradicating Lyme by 2030. “The best chance for making sure no one gets Lyme is to hit it where it lives—in the mice, birds, and ticks in the wild,” says Dr. Hu, who is co-director of the initiative. His team is testing a bait-delivered drug that targets Lyme in wild mice in Massachusetts, followed by sites in other states, to have all key target areas covered within the next five years.

    And progress for one chronic illness means progress for others. Long COVID patients are being treated with many of the same interventions that have worked for persistent Lyme symptoms. The similarities in how these diseases impact the immune system are becoming evident, Dr. Kelley says. “The patient awareness and advocacy will continue to grow from here,” she says. “We’re going to see new preventive measures to help people get their lives back faster.”One-on-one connections with people with a persistent illness (Lyme, long COVID, MS, you name it) can be a saving grace, adds Niziol. She exchanged DMs via Instagram with people who helped her find podcasts and advocacy groups. Months into treatment, Niziol is pushing herself to stay active again and remains optimistic. “I’m not going to ignore the hard parts or minimize them,” she says. “But with more understanding, more empathy, there is hope.” Right on.

      This article originally appeared in the July/August 2022 issue of Women’s Health.


      Lauren Krouse is a freelance writer who covers health, domestic violence, and self-advocacy.

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      Rocketry box office collection: Madhavan film to grow with word-of-mouth, might witness similar fate as The Kashmir Files

      R Madhavan’s Rocketry: The Nambi Effect is releasing across the country India in different languages, including Hindi, Tamil, English, Telugu, and Kannada. The film is based on the life of the former rocket scientist at Indian Space Research Organisation (ISRO) Nambi Narayanan. Along with this, the cinemagoers also have actioner Om The Battle Within releasing in the theaters this week. Both the films, belonging to different genres, will cater to a different set of audience. Film trade experts suggest while Rocketry will grow at the box office based on its word-of-mouth, Om will see a larger footfall in Tier 2 and Tier 3 cities.

      Film producer and trade analyst, Girish Johar believes the Madhavan film is “bending towards a niche audience” and is not a “hardcore commercial film”. As per him, the film is a bit upmarket and is targetting audiences in multiplexes.

      “The buzz is quite good and positive, specifically down south. Rocketry is going to get a good start at the box office. The film has been receiving a lot of accolades from the international arena as well, so that is looking positive. For the Hindi belt, it will be more reliant on word of mouth and it should be decent to start with,” Johar told indianexpress.com, while adding that Rocketry should do somewhere around a crore on its opening day. “I am looking at its weekend and lifetime box office collection, instead of day one collection, since I know the film is based more on word of mouth,” he added.

      R Madhavan plays the lead role in Rocketry. He has also written and directed the movie. Nambi Narayanan, Head of ISRO’s cryogenics division, was falsely accused of espionage and arrested in 1994. All charges against him were dismissed by the Supreme Court in 1998.

      While Girish Johar feels Rocketry will find an audience in the urban market only, film exhibitor Akshaye Rathi, who has watched the film, suggests, “It is not a film which is intellectually inaccessible to people. It is a film about a rocket scientist and not a lesson in rocket science. It is told in a manner that common of the commonest people can understand.”

      As per Rathi, the film will find traction across the country but its box office collection entirely depends on “how quickly the word of mouth spreads.” He said, “No doubt about the fact that this is not a film which will open to massive numbers on day one, it is more of a word-of-mouth film.” He also compared Rocketry to The Kashmir Files, which came as a surprise not only for the trade pundits but also for the film’s producers who never expected it to do so well at the ticket counters. “Even The Kashmir Files was also not an entertainer, but it was on an issue extremely relevant to us. That is what made it work. Having watched Rocketry, I can say it is one of the most important films made out of the Indian film industry. As a director and actor, R Madhavan has been phenomenal in this film,” shared Rathi.

      For those who are looking for hardcore Bollywood entertainment, they have Aditya Roy Kapur-led Om. The action drama also stars Sanjana Sanghi, Jackie Shroff, Ashutosh Rana and Prachi Shah.

      Aditya Roy Kapur in Om The Battle Within.

      Pegging the film’s opening day collection at around Ts 1.5-2 crore, Girish Johar said, “It’s a typical hardcore action film. The trailer is decent. Aditya Roy Kapur fans will get to watch him as a typical Hindi hero. The excitement level is decent only. I feel the film is a change of gear for Aditya Roy Kapur, until now he has done mostly romantic films, and this is a hardcore action film. This time he has tried to explore a different field.”

      Both Om and Rocketry will be released on nearly 1800-2000 screens.



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      Tonga Volcano Blasted Out Pressure Waves “Very Close to The Theoretical Limit”

      The massive eruption from the underwater Tonga volcano in the Pacific earlier this year generated a blast so powerful, it sent massive pressure waves rippling through the atmosphere and around the globe.

       

      These waves were the fastest ever observed within our atmosphere, reaching speeds of 720 miles (1,158 kilometers) per hour, a new study finds.

      “This was a genuinely huge explosion, and truly unique in terms of what’s been observed by science to date,” study lead author Corwin Wright, a Royal Society University Research Fellow based at the Centre for Space, Atmospheric and Oceanic Science at the University of Bath in the UK, said in a statement.

      The atmospheric waves triggered by the volcano traveled at unprecedented speeds, “very close to the theoretical limit”, he said. 

      Wright and his colleagues published their findings Thursday (June 30) in the journal Nature.

      The volcano – known as Hunga Tonga-Hunga Ha’apai, or just Hunga – lies about 40 miles (65 kilometers) northwest of the Tongan capital of Nuku’alofa and sits within a line of volcanoes called the Tonga-Kermadec volcanic arc.

      On 15 Jan., Hunga erupted and sent a towering plume of gas and particles billowing into the mesosphere, the third layer of the atmosphere above Earth’s surface.

      The plume reached 36 miles (58 km) tall at its highest point, making it the largest volcanic plume in the satellite record.

       

      Related: Dramatic photos show horrific aftermath of massive Tonga eruption and tsunami

      Various ground-based and spaceborne monitoring systems recorded the eruption as it unfolded, and following the event, scientists around the world immediately began sifting through this wealth of data. 

      One research team found that the atmospheric waves produced by Hunga rivaled those produced by the 1883 Krakatau eruption in Indonesia, one of the most destructive volcanic eruptions in recorded history.

      The waves produced by both volcanoes were similar in that they reached similar amplitudes and lapped the planet the same number of times: four times in one direction and three times in the other.

      Another research team found that the Hunga eruption sent ripples racing across the ocean, producing tiny, fast-traveling meteotsunamis – meaning a series of waves driven by air-pressure disturbances – that appeared in the Pacific Ocean, Atlantic Ocean, and Mediterranean Sea.

      And high above the Earth’s surface, beyond the so-called Karman line that marks the edge of space about 62 miles (100 km) above our planet, shockwaves triggered by the eruption stirred up powerful winds with speeds of up to 450 mph (720 kph), Space.com reported.

       

      Now, using similar satellite data and ground-level observations, Wright and his coauthors have confirmed that the Hunga eruption was among the most explosive volcanic events in modern history. Their results suggest that the atmospheric waves produced by the volcano lapped Earth at least six times and reached speeds up to 1,050 feet (320 meters) per second.

      “The eruption was an amazing natural experiment,” Wright said. “The data we’ve been able to gather on it will enhance our understanding of our atmosphere and will help us improve our weather and climate models.”

      Related content:

      4-foot tsunami hits Tonga after explosive eruption of underwater volcano

      ‘Invisible’ earthquake caused mysterious 2021 tsunami, scientists find

      10 times volcanoes blew our minds in 2021 

      This article was originally published by Live Science. Read the original article here.

       

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