Tag Archives: shrunk

Breakthrough in fight against world’s deadliest cancer – new drug shrunk up to 70% of pancreatic tumors in lab – Daily Mail

  1. Breakthrough in fight against world’s deadliest cancer – new drug shrunk up to 70% of pancreatic tumors in lab Daily Mail
  2. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy Nature.com
  3. Investigational therapeutic shows promise in preclinical pancreatic cancer model Medical Xpress
  4. New treatment for pancreatic cancer patients now available in the Upstate WSPA 7News
  5. Revolution Medicines Announces Publications on the Discovery and Preclinical Profile of Representative of a New Class of RAS(ON) Multi-Selective Inhibitors Designed to Block Full Spectrum of Oncogenic RAS(ON) Proteins GlobeNewswire

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Honey, I shrunk the Mac: Enthusiast makes the Mac mini more mini

Enlarge / Mac Mini mod on top of the original Mac Mini.

At 7.7×7.7×1.4 inches, the Mac mini is a tiny desktop. When the form factor debuted in 2010, it was pretty impressive. But 12 years later, with mini PCs like the Intel NUC measuring 4.6×4.4×1.5 inches, the Mac mini doesn’t feel all that mini anymore.

As it turns out, the PC is packing some extra baggage, and by getting rid of some of those parts—like an overly powerful internal power supply unit (PSU)—an enthusiast has been able to rebuild the system with a 28 percent reduction in volume while allegedly keeping the same performance as the original machine.

YouTube channel Snazzy Labs shared its miniature Mac mini mod in a video called “We made the Mac mini ACTUALLY mini!” on Tuesday. The idea stemmed from the M1-based Mac mini’s reliance on a dated design built around more power-hungry Intel chips. Part of that design included a large fan. Snazzy Labs removed the blower fan, certain that a fanless Mac mini would work because of the M1’s performance in the fanless Macbook Air laptop.

Enlarge / Getting rid of this fan allowed for a smaller footprint.

The current Mac mini also uses an excessive 150 W internal PSU. Snazzy Labs found that the computer maxes out at just 67.5 W, even with all ports pushed to their limits. Before moving to Apple’s M1 silicon, the company offered the Mac mini with an Intel Core i7 chip with a 70 W TDP.

Enlarge / 150 W power supply.

Snazzy Labs rebuilt the Mac mini to use an external power brick, enabling an even greater reduction of the chassis’ footprint. The new power supply is really a 65 W Microsoft Surface power adapter combined with an Apple MagSafe 2 board from a 2015 MacBook Pro. The board can support up to 87 W and ends in a MagSafe 2 connector.

Enlarge / External power supply.

Snazzy Labs noted that it couldn’t use an official Apple adapter because it “establish[es] a fairly elaborate handshake with the actual MacBook before beginning to charge.” The enthusiast claimed the fix is “quite safe,” though, “because the Microsoft Surface charger has smarts of its own.” If the pins short out, the charger will kick on its internal circuit protection, Snazzy Labs said.

Snazzy Labs also unscrewed the Mac mini’s three wireless antennas and used a soldering iron to take off the plastic-welded power button, followed by its ribbon cable. This let the PC ditch its wider I/O shield for a trimmer 3D-printed design.

Snazzy Labs said the mini Mac mini “benchmarks just as well as the original,” as long as it still employs its integrated heat spreader and heatsink. The small PC is also “dead-silent,” according to Snazzy Labs.

Snazzy Labs shared CAD files for the project online. If you’d rather watch someone else do the work, Snazzy Labs’ video is below:

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Man claims his penis ‘shrunk’ after contracting COVID

Talk about getting the short end of the stick.

As if contracting COVID wasn’t bad enough, a dismayed man now claims that he’s lost a whopping 1.5 inches from the length of his penis as a lingering result of the vile virus.

“My penis has shrunk,” lamented the griping guy in a letter to the “How To Do It” podcast this week.

“I’m a heterosexual man in my 30s,” he said, anonymously — only referring to himself as “coming up short.”

“In July of last year, I contracted COVID and was very sick. When I got out of the hospital, I had some erectile dysfunction issues,” he added.

The purportedly once-well-endowed man went on to explain that prior to his diagnosis, he boasted an “above average”-sized tool.

A heterosexual man in his 30s claims his penis shrunk as a result of a COVID infection.
Getty Images/iStockphoto

But, much to his chagrin, his formerly impressive privates have since lost their luster.

“[The erectile dysfunction] gradually got better with some medical attention, but I seemed to be left with a lasting problem,” he confessed. “Before I got sick [my penis] was above average. Not huge, but definitely bigger than normal. Now I’ve lost about an inch and a half and become decidedly less than average.”

He claimed that a medical adviser had attributed his pecker problems to vascular damage caused by COVID, and was warned that the impairment was likely permanent.

Doctors on the “How To Do It” podcast confirmed that men infected with COVID could experience erectile issues.
Getty Images/iStockphoto

“It shouldn’t really matter,” the man wrote. “But it has had a profound impact on my self-confidence and my abilities in bed. I know you can’t give me back my missing length and girth, but I was wondering if you could give me any advice on what to do now.”

In response to the dude’s desperate plea for penis help, Dr. Charles Welliver — a urologist and Director of Men’s Health at Albany Medical College, NY — confirmed the rare, but real havoc COVID can wreak on a man’s unmentionables.

“You can connect these dots,” the physician told Slate of the virus’ correlation to ding-a-ling disorders.

Urologist Ashley Winter says COVID can attack the blood vessels that usher blood to organs, including the penis, all throughout the body.
Getty Images/iStockphoto

“COVID [causes] a mass of respiratory symptoms that leads to a lot of the deaths,” he said. “But there’s also pretty significant vascular issues that occur with guys.”

The doctor went on to cite studies that have shown cases of men who’ve suffered from priapism — the persistent erection prompted sans sexual arousal — and erectile dysfunction (ED) after contracting COVID.

“When guys get ED, they get a lack of erections for a while, and when that happens they actually do get some shrinkage,” he added.

And his commentary on miniaturized members was backed by Dr. Ashley Winter, a urologist in Oregon, who insisted: “COVID d – – k is a real thing.”

The doctors claim that man can regain some penis length, over time, through rehabilitative medications, stretches and practices.
Getty Images/iStockphoto

“The main reason that we think this occurs is something what we call endothelial dysfunction,” she explained. “That’s basically the cells that line your blood vessels … and they’re really important for the function of many different organs.” 

The health care pro went on to note that when COVID infects those vital cells, it can take a toll on a number of organs. 

“And because the erection is a blood flow-event … When those blood vessels are affected, you can get the erectile dysfunction,” she said.

However, despite the prognosis “coming up short” received from his doom-and-gloom doctor, both urologists agreed that rehabilitative practices like doing “penis push-ups” or purchasing a “penis vacuum,” could restore length over time.

“A typical regimen would be starting something like Viagra or Cialis to improve blood flow,” advised Winter. “Another thing would be to buy a penis vacuum device and do penis exercise with it or penis push-ups.”

The doctors say COVID has not been considered transmittable through an infected man’s genitals.
Korean Society for Sexual Medici

She also suggested stretching the penis with a traction device named RestoreX, which she says has reportedly elongated shortened wee-wees by 1 to 2 centimeters with consistent use.

“These are easy things you can do at home to either prevent shortening or actually get back length that you’ve lost,” she assured.

So, to make a long story short, just hang in there guys. There’s hope.

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