Tag Archives: Russias

Russia’s Sputnik V vaccine is 91.6% effective against symptomatic Covid-19

The preliminary findings were published in The Lancet on Tuesday and are based on data gathered from 19,866 participants, of which around three-quarters (14,964) received two doses of the vaccine and a quarter (4,902) were given a placebo.

Sixteen cases of symptomatic Covid-19 were confirmed in the vaccine group 21 days after participants received the first vaccine dose. Sixty two cases were found in the placebo group — equating to an efficacy of 91.6%.

The trial included 2,144 people over the age of 60 and a sub-analysis conducted on this group revealed the vaccine was well tolerated and had a similar efficacy of 91.8%.

The team also analyzed the efficacy of the vaccine against severe and moderate Covid-19 disease and 21 days after the first dose no severe or moderate cases were reported in the vaccinated group, while 20 were reported in the placebo group.

Serious adverse events were also rare and none was considered to be associated with vaccination. The majority of side-effects that were reported were mild, such as pain at the injection site, flu like symptoms and low energy levels, according to the study.

The analysis includes only symptomatic cases of Covid-19, however, and the authors note more research is needed to understand the vaccine’s efficacy against asymptomatic Covid-19, transmission and how long protection may last.

The majority of participants in the trial were also white so further research is needed to confirm the results across other ethic groups. The trial is also ongoing and is aiming to include a total of 40,000 participants.

Dr. Inna V Dolzhikova, co-lead author of the study, said the analysis suggested the vaccine had “high efficacy, immunogenicity, and a good tolerability profile in participants aged 18 years or older.”

Dolzhikova works at Russia’s Gamaleya National Research Centre for Epidemiology and Microbiology, which developed the vaccine.

The people in the trial were given PCR Covid-19 tests when they received the second shot. They took a further test if they reported symptoms of respiratory infection.

The Sputnik V vaccine is a two-dose adenoviral vector vaccine using two different adenoviruses for each dose, with doses administered 21 days apart. With this type of vaccine, an adenovirus is altered so that it can deliver a piece of genetic material from the virus that causes Covid-19 into the body and get cells to express the spike induce found on the virus and induce an immune response. It’s an approach similar to the vaccines developed by AstraZeneca and Johnson & Johnson.

The authors say that using a different adenovirus vector for the booster vaccination may help create a more powerful immune response.

One advantage of adenoviral vaccines is that they do not need to be stored and transported in extremely cold temperatures, scientists say. Sputnik V only needs to be refrigerated and costs $10 per dose, according to Russian Direct Investment Fund, which funded vaccine production and is responsible for selling it globally.

“This is a useful addition to the published data on Covid-19 vaccine effectiveness,” Dr. Julian Tang, clinical virologist at the University of Leicester.

But he highlighted that “median follow up was 48 days from the first dose, so the study cannot assess the full duration of protection.”

The vaccine’s production has been funded by the Russian Direct Investment Fund (RDIF), which is also responsible for selling it globally.

The vaccine is already approved in Russia, Belarus, Serbia, Argentina, Bolivia, Algeria, Venezuela, Paraguay, Turkmenistan, Hungary, UAE, Iran, Guinea, Tunisia, Armenia and the Palestinian territories. Sputnik V has so far been administered to more than 2 million people worldwide.

Russia drew criticism from scientific circles last year when it approved Sputnik V for public use in August — before the crucial Phase 3 trials had been completed.

“Despite the earlier misgivings about the way this Russian Sputnik V vaccine was rolled out more widely — ahead of sufficient Phase 3 trial data — this approach has been justified to some extent now,” Tang said.

“The vaccine trial results are coming thick and fast as high infection rates in areas where Phase 3 clinical trials provide increasing amounts of data that together encourages us to believe that vaccines will soon be able to drive down the human cost of Covid-19,” added Alexander Edwards, associate professor in Biomedical Technology at the Reading School of Pharmacy, University of Reading.

“Manufacturing may remain a bottleneck for months to come, so the more vaccines available, the better for global health,” he said.

Correction: An earlier version of this story incorrectly stated the amount of serious adverse events associated with vaccination. A minor number of serious adverse events occurred and were rare, but none was associated with vaccination.

CNN’s Meera Senthilingam, Jamie Gumbrecht, Jessica Firger and Zahra Ullah contributed to this report.

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Unsolved mystery of Russia’s missing hikers may have finally been cracked

The mystery of the Dyatlov Pass has raised questions for over half a century.


Soviet investigators/Creative Commons

The Dyatlov Pass incident is a spooky tale most often told in hushed tones around a campfire, but this very real — and very mysterious — event has long been the subject of conspiracy theories, scientific conjecture and even a movie or two. But the truth of what drove nine experienced hikers to slash through the safety of their own tent and flee, half-dressed into the snow of the Ural mountains, has remained inconclusive for over half a century. 

That is, until now. After 62 years of speculation, scientists believe they may have figured out what happened in the Ural Mountains, all those years ago. 

Thanks to simulations, analytical models and even some borrowed Disney technology, the data indicates an impactful force of nature could very well be the conclusive answer. 

What is the Dyatlov Pass mystery?

In January 1959, a team of experienced Russian mountaineers were trekking in the Ural Mountains — at least, they were, until they perished under mysterious circumstances. 

Personal diaries and film discovered on site confirm that the team had made camp on a stretch of the slopes known as Kholat Saykhl, or “dead mountain.” However, something caused the hikers to flee in the middle of the night, cutting their way out of the tent and sprawling across the mountain — barely dressed despite subzero temperatures and a thick layer of snow.

When a search and rescue team finally found them, scattered over the pass weeks later, they discovered that while six of the hikers had died from hypothermia, the remaining three hikers had been killed by extreme physical trauma. There were body parts missing — one hiker’s eyes, another’s tongue — and severe skeletal damage to some of the skulls and chests.

The only problem? There was no convincing evidence to explain why or how this had happened. At the time, the investigators concluded only that an unknown but powerful “natural force” had compelled them to leave their tent. Conspiracies range from katabatic winds through to Yeti attack and even infrasound-induced panic, but no definitive conclusion was ever made to explain the deaths. 

Until, potentially, now.

Simulations, Disney and a potential answer

In an article published in the journal Communications Earth and Environment, researchers identified data supporting the theory that a small, impactful avalanche could have been the culprit.

It’s not the first time such a hypothesis has arisen. In fact, it was one of the first conclusions drawn — it just had no supporting evidence. In 2019, a team of Russian scientists also concluded that it was an avalanche, but the data to support the theory was once again lacking. There had been no definitive evidence of an avalanche — even a small one. The topography and snowfall levels didn’t match such an incident.

Now, however, a team from the Snow Avalanche Simulation Laboratory at the École polytechnique fédérale in Lausanne, Switzerland, has been able to use analytical models, simulations and even technology from Disney’s animation studios to explain how an avalanche may have occurred without leaving behind evidence.

Reported by National Geographic, the data indicated the avalanche would have been particularly small — perhaps as small as 16 feet of ice and snow, compacted into a solid slab. This would allow for the conditions to mask the phenomena over time, with snowfall obscuring any debris, while still creating enough of a threat to compel the hikers to slash their way out.

But it still didn’t explain the extreme trauma left on some of the bodies. To answer that question, the team looked to Disney’s Frozen. Johan Gaume, head of the laboratory, combined their simulation tools with animation models borrowed from Frozen’s creative team to analyze how the impact of the avalanche would affect the bodies.

Using the simulation, enhanced by these animation models, the team was able to conclude that the suspected avalanche could have had enough of an impact if the hikers had arranged their bedding on top of their skis, providing a rigid base upon which the force would have been exerted — crushing skulls and chests between the two hard forces.

There’s still little evidence as to what happened next, given that all the hikers were found outside the tent, but the best theory is that they then tried to escape the avalanche and rescue their injured teammates — though their injuries and the extreme temperature would eventually prove fatal. As for the missing body parts? Animal scavengers are the likely culprit.

So while the study goes a long way in explaining a possible, even likely, scenario for the deaths of the hikers on Dyatlov Pass, a lot of questions still remain. 

And those questions are inevitably going to keep conspiracy theorists busy speculating for years to come.

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Russia’s Putin Faces Rising Discontent Amid Alexei Navalny Protests

MOSCOW—The protests that swept Russia this weekend in support of jailed opposition leader Alexei Navalny show the challenge President Vladimir Putin faces in managing social discontent ahead of parliamentary elections this year.

Saturday’s unsanctioned rallies were among the largest in recent years and saw tens of thousands of people brave freezing temperatures, the threat of the pandemic and the possibility of incarceration. Security forces detained more than 3,500 people—the largest number in at least nine years, according to independent monitors.

The protests have left the Kremlin facing a dilemma: Either bow to the pressure from the street and undermine its own authority by releasing Mr. Navalny or risk inciting more backlash and unifying the opposition by keeping him behind bars.

“There are few good options for Putin,” said Abbas Gallyamov, a Moscow-based political consultant and former speechwriter for Mr. Putin. “It seems like Navalny is attacking and the Kremlin is defending.”

Mr. Putin’s approval ratings have swooned in recent years amid a sluggish economy and protest activity. Observers say the Navalny demonstrations, if sustained, could pose a threat to Mr. Putin’s dominance despite constitutional changes approved last year that could allow him to stay in power until 2036.

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