Tag Archives: Pivotal

Sarepta Therapeutics Announces Topline Results from EMBARK, a Global Pivotal Study of ELEVIDYS Gene Therapy for Duchenne Muscular Dystrophy – Business Wire

  1. Sarepta Therapeutics Announces Topline Results from EMBARK, a Global Pivotal Study of ELEVIDYS Gene Therapy for Duchenne Muscular Dystrophy Business Wire
  2. Sarepta’s Duchenne gene therapy fails to meet primary endpoint in pivotal trial STAT
  3. [Ad hoc announcement pursuant to Art. 53 LR] Roche announces EMBARK trial in Duchenne muscular dystrophy (DMD) did not reach primary endpoint, but shows positive efficacy outcomes on all timed functional key endpoints GlobeNewswire
  4. Even after primary miss, Sarepta to seek wider Elevidys approval FiercePharma
  5. Sarepta’s upcoming data on Duchenne gene therapy: What to know STAT
  6. View Full Coverage on Google News

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Tupac’s sister calls murder charge ‘pivotal moment’ after 27 years, warns ‘multiple hands’ involved in slaying – New York Post

  1. Tupac’s sister calls murder charge ‘pivotal moment’ after 27 years, warns ‘multiple hands’ involved in slaying New York Post
  2. Jada Pinkett Smith Reacts to Tupac Shakur Suspect Arrest: ‘Now I Hope We Can Get Some Answers’ PEOPLE
  3. The man charged in Tupac Shakur’s 1996 shooting death has long put himself at the crime scene. Here’s what we know about him CNN
  4. If Tupac Has Lived The Root
  5. Cops likely waited years to arrest Tupac murder suspect Duane ‘Keefe D’ Davis so he would air more confessions: expert New York Post
  6. View Full Coverage on Google News

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Tupac’s Sister Calls Murder Charge Pivotal Moment, But Reminds Fans: “Multiple Hands Involved” – Deadline

  1. Tupac’s Sister Calls Murder Charge Pivotal Moment, But Reminds Fans: “Multiple Hands Involved” Deadline
  2. The man charged in Tupac Shakur’s 1996 shooting death has long put himself at the crime scene. Here’s what we know about him CNN
  3. Jada Pinkett Smith Reacts to Tupac Shakur Suspect Arrest: ‘Now I Hope We Can Get Some Answers’ PEOPLE
  4. Cops likely waited over two decades to arrest Tupac murder suspect Duane ‘Keefe D’ Davis so he would air more confessions: expert New York Post
  5. Mora denies story that claimed he knew identity of Tupac killer Daily Mail
  6. View Full Coverage on Google News

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G1 Therapeutics Announces Top Line Results from Pivotal Phase 3 Trial of Trilaciclib in Patients Receiving Triplet Therapy with FOLFOXIRI + Bevacizumab for Metastatic Colorectal Cancer (CRC) (PRESERVE 1) – Yahoo Finance

  1. G1 Therapeutics Announces Top Line Results from Pivotal Phase 3 Trial of Trilaciclib in Patients Receiving Triplet Therapy with FOLFOXIRI + Bevacizumab for Metastatic Colorectal Cancer (CRC) (PRESERVE 1) Yahoo Finance
  2. GTHX stock falls on decision to halt colorectal cancer trial (NASDAQ:GTHX) Seeking Alpha
  3. Pharma Stock Hits Record Low Due to Pulled Study Schaeffers Research
  4. G1 Therapeutics to halt drug trial in colon cancer, shares plunge Reuters.com
  5. Cosela/Immunochemotherapy Trial for Colorectal Cancer Stopped for Limited Anti-Tumor Efficacy Data Curetoday.com
  6. View Full Coverage on Google News

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‘You People’ Actor Claims Jonah Hill and Lauren London’s Pivotal Kiss Was Faked With CGI – Hollywood Reporter

  1. ‘You People’ Actor Claims Jonah Hill and Lauren London’s Pivotal Kiss Was Faked With CGI Hollywood Reporter
  2. Jonah Hill and Lauren London’s You People Kiss Was Faked with CGI, Costar Claims Yahoo Entertainment
  3. Jonah Hill And Lauren London’s ‘You People’ Kiss Was CGI, According To Costar HuffPost
  4. Jonah Hill and Lauren London had ‘a FAKE KISS’ created by CGI in You People says costar Daily Mail
  5. Was The ‘You People’ Kiss Between Jonah Hill and Lauren London Faked Using CGI? Rumors Explode After a Controversial Podcast Episode Drops Decider
  6. View Full Coverage on Google News

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Moderna jumps into pivotal pack with promising RSV data as big rivals face off in megablockbuster race – Endpoints News

David Kessler, the Biden administration’s chief science officer for Covid-19, will step down this week amid question marks about what the next iteration of the Covid vaccine (from booster to price) will look like moving forward, and shortly after the admin’s other long-time chief medical advisor, Tony Fauci, stepped down.

Buttressed by his FDA commissioner experience from 1990-1997, Kessler stood atop the reincarnated version of Operation Warp Speed, helping to bring the bivalent booster to millions, as well as millions of new doses of oral antivirals.

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NFL Week 10 injuries: Josh Allen, Kyler Murray, Matthew Stafford questionable for pivotal games

The second half of the 2022 NFL regular season got underway on Thursday night when the Panthers were able to fend off the Falcons at home, and now we have a full slate of Sunday games on deck for Week 10. That includes an international affair between the Seahawks and Buccaneers for the history books. For the first time ever, a regular-season game will be played in Munich. Of course, that’ll be appointment viewing early Sunday morning, as will the rest of the slate. 

As is the case each week, a new group of games comes a new collection of injuries that we need to follow. This week in particular, several quarterbacks have their statuses up in the air, so all eyes will be on them. With teams finishing up the week of practice, they’ve released their final injury reports and rolled out game statuses for Week 10. Below, you’ll be able to find each of those reports and a breakdown of some of the biggest injuries. 

All NFL odds via Caesars Sportsbook.

Seahawks at Buccaneers (-2.5), in Munich

Seattle is pretty healthy coming into this international head-to-head. Goodwin is officially listed as questionable, but he was able to practice fully on Friday, which is an encouraging sign of his availability. Meanwhile, Gillaspia was the only other player listed on the final injury report and was ruled out after not practicing all week.

Brate is the only player listed on the Bucs final injury report who made the trip to Germany. He was a full participant throughout the week, so it does seem like he has a good chance of playing. Despite being listed as questionable all week, wideout Mike Evans (ribs, ankle) does not carry a designation. It’s also worth noting that safety Antoine Winfield Jr. cleared concussion protocol and will play. 

The Vikings have had a light injury report all season, but Tomlinson being out again is their first major player missing a game in weeks. Starting center Garrett Bradbury (ankle) was a full participant Friday after being limited Thursday. He was not given an injury designation. 

After missing the first two practices of the week, Allen returned to the field on Friday in a limited capacity and was officially listed as questionable for Sunday’s matchup against Minnesota. Sean McDermott told reporters earlier on Friday that Allen’s status is really “hour-to-hour” so it does seem like he is a true game-time decision. 

The promising news for Detroit is that running back D’Andre Swift not only doesn’t carry an injury designation for this game, but he was able to practice fully for the first time in weeks on Friday. Meanwhile, Reynolds was unable to hit the field at all this week, so it’s not surprising to see him already ruled out.

Jenkins being limited in Friday’s practice is something to monitor for the Bears. He’s been the team’s best offensive lineman this year, a force in the run game. If he can’t go, Michael Schofield is slated to start. No Vildor will cause problems for the Bears in the nickel defense, especially if Johnson can’t play. Johnson is arguably the team’s best cornerback. 

  • Broncos: TE Andrew Beck (hamstring), OLB Baron Browning (hamstring), WR KJ Hamler (hamstring) OUT; T Cameron Fleming (quad), S Justin Simmons (knee), CB Darius Phillips (illness), LB Nik Bonitto (illness), WR Kendall Hinton (illness) QUESTIONABLE
  • Titans: LB Zach Cunningham (elbow), OLB Bud Dupree (hip), S Amani Hooker (shoulder), DE Jeffery Simmons (ankle), DB Josh Thompson (knee) OUT; CB Kristian Fulton (hamstring), DT Kevin Strong (ankle), QB Ryan Tannehill (ankle) QUESTIONABLE

Hamler and Beck both suffered hamstring injuries in practice for the Broncos this week, which head coach Nathaniel Hackett will be evaluating coming out of the bye week. Jonathon Cooper and Jacob Martin were the only outside linebackers on the Broncos roster that were able to practice Friday, which could leave Denver thin at the position if Bonitto can’t go this week. 

The Titans have four defensive starters out of this one, but the major status for Sunday’s game is Tannehill. The quarterback was limited in Friday’s practice. Head coach Mike Vrabel was noncommittal on Tannehill, but said the quarterback was “making progress.” If Tannehill misses his third straight game, Malik Willis will start. 

  • Jaguars: S Rayshawn Jenkins (concussion) QUESTIONABLE
  • Chiefs: WR Mecole Hardman (abdomen) OUT; RB Jerick McKinnon (shoulder, knee, hamstring) QUESTIONABLE

Jacksonville continues to be one of the healthiest teams in the NFL. Only Jenkins carries a designation entering Week 10 and he was limited in practice on Friday. Tight end Evan Engram was listed on the injury report with a back injury, but practiced fully and is good to go for Sunday. 

Hardman didn’t practice at all this week due to an abdomen injury and will be held out of Kansas City’s Week 10 matchup against the Jags. Meanwhile, McKinnon was downgraded to a limited participant during Friday’s practice after being a full participant the two days prior. The pass-catching back is dealing with an array of injuries and is now officially questionable. 

The bye week wasn’t enough for the Browns to get Njoku healthy and ready to go for this game against Miami. This is the second game that Njoku has missed due to a high-ankle injury he suffered against the Ravens in Week 7. With him sidelined, Harrison Bryant and Pharaoh Brown will be the club’s top tight ends. Meanwhile, Owusu-Koramoah will also miss his second straight game. 

Armstead sat out practice Friday and was listed as questionable, but that’s been normal on the injury report this year. He typically hasn’t practiced more than once a week this year a she deals with a toe injury, but has played eight games. Jackson may also be in line to play his first game since Week 1, but he was limited Friday. 

Houston may be getting back its top two wide receivers in Week 10. Both Cooks and Collins were able to practice on a limited basis this week and are officially listed as questionable. Reeves-Maybin was also upgraded to a full participant on Friday, which bodes well for his prospects of playing. 

Golladay hasn’t played since Week 4 but is expected to be available on Sunday against Houston. Golladay, who has largely disappointed since arriving in New York, was limited throughout the week and is officially listed as questionable. Flott and Ximines were also limited all week. As for Neal, this is the second straight game he’s missed due to his knee injury.

None of the players who were ruled out practiced at all this week, including Lattimore. While New Orleans continues to deal with a bunch of injuries, they did get an encouraging sign from Jarvis Landry. The veteran wide receiver does not carry an injury designation and is in line to play on Sunday. 

Jackson and Witherspoon did not practice all week and have since been ruled out for Week 10. Dotson popped up on the injury report on Friday as a limited participant due to an abdomen injury and is now listed as questionable. Meanwhile, pass rusher T.J. Watt told reporters that he expects to play Sunday and does not anticipate being on any sort of snap count. 

The major development for the Colts is Jonathan Taylor (ankle), who was a full participant in Friday’s practice and was not given an injury designation. Jackson will be out, so Zack Moss, and possibly Jordan Wilkins, will spell Taylor against the Raiders. Kylen Granson will be the lone tight end if Alie-Cox — who was limited Friday — can’t go. Paye hasn’t practiced all week, so he’ll be a game-time decision. 

The Raiders only have Perryman on the injury report, and he was limited in Friday’s practice. Las Vegas will be without Darren Waller (hamstring) and Hunter Renfrow (oblique), as both players were placed on injured/reserve Thursday.

Elliott may be questionable for the Cowboys, but he’s expected to play based on the praise of Jerry Jones and Mike McCarthy. Dalton Schultz (knee), Micah Parsons (shoulder) and Michael Gallup (chest) were also cleared to play this week. 

The Packers have three starters out in Doubs, Campbell, and Stokes, but have other starters that weren’t given injury designations. Allen Lazard (shoulder) and Sammy Watkins (knee) are available at wide receiver, Aaron Jones (ankle) will play, and Jon Runyan (knee) and Elgton Jenkins (knee) will play. Bakhtiari was limited Friday, so his status for Sunday will be monitored. 

  • Cardinals: G Max Garcia (shoulder), C Rodney Hudson (knee) OUT; CB Byron Murphy (back), QB Kyler Murray (hamstring), LB Dennis Gardeck (ankle), T D.J. Humphries (back), CB Christian Matthew (hamstring), WR Greg Dortch (groin) QUESTIONABLE
  • Rams: RB Malcolm Brown (hamstring), LB Travin Howard (hip) OUT; NT Greg Gaines (elbow), G Alaric Jackson (knee) DOUBTFUL; C Brian Allen (knee), CB Robert Rochell (illness), QB Matthew Stafford (concussion) QUESTIONABLE

The Cardinals have a monster list of injuries, starting with Murray — who is a game-time decision. Murray was limited the last two days with a hamstring injury suffered last week. Murray’s mobility is limited, but he can stay in the pocket and play — per head coach Kliff Kingsbury. The Cardinals are also going to monitor the status of Murphy, who didn’t practice all week but was still listed as questionable. 

Stafford is the player to watch for the Rams, as he’ll have to clear concussion protocol in order to play. If not, John Wolford will get the start for Los Angeles. Los Angeles is getting some reinforcements with right guard Coleman Shelton and running back Kyren Williams both being active for Sunday’s game. 

Allen is still “week-to-week” with his injury, not having played since Week 7 — when he logged just 22 snaps (has played 45 all year). Williams is still out with his ankle injury, missing his third straight game. he wasn’t placed on injured reserve, so that will be something to watch in Week 11. Joey Bosa hasn’t been activated from injured reserve, but there’s some hope  he may be available Sunday. DeAndre Carter and Josh Palmer are the top two options at wide receiver this week. If Pipkins can’t go, both starting tackles (Rashawn Slater and Pipkins) will be out for Los Angeles. 

Nick Bosa is the only starter who is expected to play on the 49ers defensive line. Javon Kinlaw could be activated by next week and Ebukam is doubtful for Sunday’s game. Drake Jackson could see more snaps, per head coach Kyle Shanahan. Deebo Samuel was not on the injury report. 

  • Commanders: N/A
  • Eagles: N/A

Analysis to come.

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Padres vs. Dodgers score: Live updates as San Diego hosts pivotal NLDS Game 3

The NL East rival Los Angeles Dodgers and San Diego Padres continue their NLDS matchup with Game 3 at Petco Park on Friday night. The will be the first postseason game with fans at Petco Park since Game 2 of the 2006 NLDS. Hoping to take a 2-1 lead in the series, the Padres are taking a 2-1 lead into the late innings. Here’s how you can watch Game 3.

The Dodgers started All-Star righty Tony Gonsolin and he got just four outs before exiting but only allowed one run. San Diego started Blake Snell, who labored through his Wild Card Series start against the New York Mets (10 of 19 batters faced reached base) but was dominant down the stretch in the regular season. Snell was lifted after 5 1/3 innings and gave up just one run.

Following along with our live updates and analysis of NLDS Game 3 between the Dodgers and Padres below.

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‘Beyond the dark ages’: USU’s Space Dynamics Lab supplies pivotal parts to Webb Telescope

NASA revealed four new images last week taken by the James Webb Telescope. This image shows the Carina Nebula. Without crucial parts engineered by Utah State University’s Space Dynamics Lab, NASA’s James Webb Telescope may never have been able to capture the stunning images that it has so far. (NASA, ESA, CSA, and STScI)

Estimated read time: 3-4 minutes

LOGAN — Standing within the confines of the NASA Goddard Space Flight Center, Glen Hansen noticed a poster on the wall that intrigued him.

The poster said, “Looking beyond the dark ages.”

“It’s just great to see that the telescope is actually doing that. It’s looked well beyond where we’ve been able to see before, not only in space but in time, as we look back at the early beginnings of the universe,” said Hansen, chief engineer with Utah State University’s Space Dynamics Laboratory.

Hansen wasn’t just there as a spectator that day, either. He and his team at the lab we’re actively involved in creating technology for the now famed James Webb Space Telescope.

“To be a part of that, it makes you feel really good,” Hansen said.

Hansen said that the Space Dynamics Lab was working on developing technology for NASA’s SABER mission when they were selected to develop similar technology to support the Webb telescope “based on our heritage with being able to provide these types of straps.”

Without the work done by the Space Dynamics Lab, the Webb telescope may never have been able to capture the stunning images that it has so far.

The lab’s contribution to the telescope was to develop the thermal control system — in particular, heat straps that “conduct the heat away from each of the instruments out to the radiators on the telescope” and support structures for the straps.

Hansen explained that the instruments on the telescope endure extreme cold while in space, all the way down to 4 K, or -452 degrees Fahrenheit.

“The reason why they need to be cold like that is because you’re looking at some very cold objects out in deep space, so if your detectors are warmer than the object that you’re trying to see, you won’t see that,” Hansen said.

He said it’s like trying to stargaze in downtown Salt Lake City as opposed to doing so somewhere high up in the Wasatch Mountains, or deep within a desert in southern Utah.

“If you move out away from the city … you can see a whole myriad of stars out there, and that’s kind of the way it is with the detectors,” Hansen said. “If they’re not colder than the objects they’re trying to see … they get swamped by that infrared heat that the surroundings are radiating.”

So, the thermal control system and the heat straps engineered by the Space Dynamics Lab are essentially what keep the detectors cold, moving the heat that the detectors generate to the radiator to allow a peek into deep space.

Without the thermal control system, the telescope “would never be able to see what they’re trying to detect,” Hansen said.

For Hansen and the rest of the crew at the Space Dynamics Lab, who spent the better part of the last five years working on the technology, seeing the images that come back from the telescope is an extremely gratifying feeling.

“To finally see that it gets out there and then see the images come back, it’s very fulfilling,” Hansen said. “It’s a great sense of accomplishment.”

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Logan Stefanich is a reporter with KSL.com, covering southern Utah communities, education, business and military news.

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Finding rifle was pivotal to capturing Highland Park parade shooting suspect, chief says

The 21-year-old suspect in the Highland Park Fourth of July parade shooting showed no emotion during his virtual court appearance on Wednesday. 

Investigators say Robert Crimo III took aim and fired 83 rounds at spectators from a rooftop, stopping to reload his rifle. Then he made a run for it in women’s clothing, leaving his gun behind. 

“He indiscriminately fired at the crowd of people and struck people at random,” Highland Park Police chief Lou Jogmen told CBS News in an exclusive interview. 

It was an attack he’d allegedly been planning for weeks. 

“There was quite a bit of preplanning that went into it and he was quite motivated to carry out the attack,”  Jogmen said.

“My instant thought was this person could potentially get away and not be held accountable for this,” Jogmen said. “And that concern stayed with me throughout the first couple of hours because we had such a poor description. Not a good trail.”

Finding the gun is what “set this investigation on a totally different trajectory,” Jogmen said. 

“In this case, we knew the make, the model, the serial number, and then we went through with the tracing process directly to the manufacturer,” ATF special agent in charge Kristen de Tineo told CBS News.  All of that information allowed the ATF to identify the suspect.

During the frantic eight-hour manhunt, police say the suspect stopped to see an acquaintance and then drove two and a half hours to Madison, Wisconsin, where he contemplated carrying out another attack when he spotted a large gathering. In the car with him was another gun and approximately 60 rounds of ammunition. CBS News obtained a photo of the gun that was in the car. 

The gun that was found in the Highland Park parade shooting suspect’s car when he was arrested after a manhunt. 

CBS News


Jogmen said investigators don’t yet have a motive. 

“We really don’t have any better understanding today than we did when we first started talking to him about the why in particular,” he said. 

Police said the suspect confessed to the shooting that killed at least seven people and wounded 38 others. He’s being held without bond and more charges are expected to be filed against him in the coming weeks. 

The Illinois State Police say the alleged gunman passed four background checks in 2020 and 2021 as he amassed an arsenal of five firearms. The first one was purchased after the suspect’s father signed an authorization form. 

Despite two encounters with police in 2019 involving threats of violence to himself or family members and a series of troubling social media posts, his parents’ attorney says they saw no warning signs. 

“To them, he was just their son,” attorney Steve Greenberg told CBS News. “He was a little bit eccentric. He was into music. He was into art. But to them, he was just their son and there weren’t really any red flags. It’s a terrible tragedy for everybody.” 

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