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Ultraprocessed foods linked to ovarian and other cancer deaths, study finds

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CNN
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Eating more ultraprocessed foods raises the risk of developing and dying from cancer, especially ovarian cancer, according to a new study of over 197,000 people in the United Kingdom, over half of whom were women.

Overly processed foods include prepackaged soups, sauces, frozen pizza and ready-to-eat meals, as well as hot dogs, sausages, french fries, sodas, store-bought cookies, cakes, candies, doughnuts, ice cream and many more.

“Ultra-processed foods are produced with industrially derived ingredients and often use food additives to adjust colour, flavour, consistency, texture, or extend shelf life,” said first author Dr. Kiara Chang, a National Institute for Health and Care Research fellow at Imperial College London’s School of Public Health, in a statement.

“Our bodies may not react the same way to these ultra-processed ingredients and additives as they do to fresh and nutritious minimally processed foods,” Chang said.

However, people who eat more ultra-processed foods also tend to “drink more fizzy drinks and less tea and coffee, as well as less vegetables and other foods associated with a healthy dietary pattern,” said Duane Mellor, a registered dietitian and senior teaching fellow at Aston Medical School in Birmingham, UK, in an email.

“This could mean that it may not be an effect specifically of the ultra-processed foods themselves, but instead reflect the impact of a lower intake of healthier food,” said Mellor, who was not involved in the study.

The study, published Tuesday in the journal eClinicalMedicine, looked at the association between eating ultraprocessed foods and 34 different types of cancer over a 10-year period.

Researchers examined information on the eating habits of 197,426 people who were part of the UK Biobank, a large biomedical database and research resource that followed residents from 2006 to 2010.

The amount of ultraprocessed foods consumed by people in the study ranged from a low of 9.1% to a high of 41.4% of their diet, the study found.

Eating patterns were then compared with medical records that listed both diagnoses and deaths from cancer.

Each 10% increase in ultraprocessed food consumption was associated with a 2% increase in developing any cancer, and a 19% increased risk for being diagnosed with ovarian cancer, according to a statement issued by Imperial College London.

Deaths from cancers also increased, the study found. For each additional 10% increase in ultraprocessed food consumption, the risk of dying from any cancer increased by 6%, while the risk of dying from ovarian cancer rose by 30%, according to the statement.

“These associations persisted after adjustment for a range of socio-demographic, smoking status, physical activity, and key dietary factors,” the authors wrote.

When it comes to death from cancer among women, ovarian cancer is ranked fifth, “accounting for more deaths than any other cancer of the female reproductive system,” noted the American Cancer Society.

“The findings add to previous studies showing an association between a greater proportion of ultra-processed foods (UPFs) in the diet and a higher risk of obesity, heart attacks, stroke, and type 2 diabetes,” said Simon Steenson, a nutrition scientist at the British Nutrition Foundation, a charity partially supported by food producers and manufacturers. Steenson was not involved in the new study.

“However, an important limitation of these previous studies and the new analysis published today is that the findings are observational and so do not provide evidence of a clear causal link between UPFs and cancer, or the risk of other diseases,” Steenson said in an email.

People who ate the most ultraprocessed foods “were younger and less likely to have a family history of cancer,” Chang and her colleagues wrote.

High consumers of ultraprocessed foods were less likely to do physical activity and more likely to be classified as obese. These people were also likely to have lower household incomes and education and live in the most underprivileged communities, the study found.

“This study adds to the growing evidence that ultra-processed foods are likely to negatively impact our health including our risk for cancer,” said Dr. Eszter Vamos, the study’s lead author and a clinical senior lecturer at Imperial College London’s School of Public Health in a statement.

This latest research is not the first to show an association between a high intake of ultraprocessed foods and cancer.

A 2022 study examined the diets of over 200,000 men and women in the United States for up to 28 years and found a link between ultraprocessed foods and colorectal cancer — the third most diagnosed cancer in the United States — in men, but not women.

And there are “literally hundreds of studies (that) link ultraprocessed foods to obesity, cancer, cardiovascular disease, and overall mortality,” Marion Nestle, the Paulette Goddard professor emerita of nutrition, food studies and public health at New York University told CNN previously.

While the new UK-based study cannot prove causation, only an association, “other available evidence shows that reducing ultra-processed foods in our diet could provide important health benefits,” Vamos said.

“Further research is needed to confirm these findings and understand the best public health strategies to reduce the widespread presence and harms of ultra-processed foods in our diet,” she added.

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My Belly Button Saved My Life

I knew what to look for, but I missed the signs. 

I went to an ovarian cancer awareness walk a decade before I was diagnosed with it at the age of 44. I took home pamphlets describing it as a “silent killer” because most people miss the symptoms, which include frequent urination, feeling full quickly, changes in bowel habits, bloating, fatigue, upset stomach, back pain, pain during sex, constipation and heavy periods.

Unfortunately, every one of these symptoms could be a sign of something else, so we are often misdiagnosed and don’t know we have ovarian cancer until it’s already advanced. It is incurable and often fatal.

For 10 years after the awareness walk, I didn’t notice any changes to my health that I thought were unusual. I continued getting Pap smears at the recommended intervals and began getting yearly mammograms at age 41, even though my primary care doctor advised against it. “There are too many false positives,” she said.

It was a dermatologist, not a gynecologist, who diagnosed me. I had a small growth, the size and color of a pencil eraser, in my navel. When the dermatologist removed it, he thought it was something harmless. The biopsy said otherwise. 

The call came on April 1, 2020. That first day, all I could do was get my blood tested. At this point in the pandemic, we didn’t know if we could get COVID-19 from surfaces. I used my shirt sleeve to open doors, then woke up in the middle of the night wearing the same shirt and wondering whether there was coronavirus on my sleeve. 



The author learned the symptoms of ovarian cancer a decade before her own diagnosis. In this 2010 photo taken at a Cancer Walk, she’s wearing pink for breast cancer awareness and a small teal ribbon signifying ovarian cancer.

The blood test found elevated levels of cancer antigen 125, a tumor marker that is not an entirely reliable indicator of ovarian cancer. Too many false positives. Also false negatives. My CT scan a week later showed that each ovary had been overtaken by tumors the size of small citrus fruit, and I had a third tumor the size of a larger citrus fruit in the center of my abdomen. The cancer had spread up through my umbilicus and out my navel, which was, as far as I knew at the time, the only symptom I had.

There seem to be as many ways to find the cancer as there are people who have it. According to the American Cancer Society, that’s 1 in 78 people with ovaries, of all ages. One in 108 will die of it.

A Pap smear doesn’t detect ovarian cancer, and there’s no ovarian version of a mammogram. Among the people in my online support groups, some discovered their cancer while they were pregnant, or trying to figure out why they weren’t getting pregnant. Some had unusual bleeding, or another emergent event that landed them in a hospital.

Countless others sought medical help for the symptoms listed above, but were misdiagnosed with something like irritable bowel syndrome, heartburn, diverticulitis or menopause. Too many patients were sent home believing it was nothing, or they were making too big a deal out of it, or it was their fault because they were overweight.

We misdiagnose ourselves, avoiding trips to the emergency room for those same three reasons. I did. In hindsight, I did have excruciating back pain six months before I was diagnosed. I thought I’d strained my back lifting my 85-pound elderly dog. I learned to lift with my legs and it mostly went away. I can’t imagine a scenario where my efforts to alleviate lower back pain would have led me to ask about ovarian cancer.

More than a year after my diagnosis, after several months being cancer-free, I recalled intermittent sharp chest pains in recent years. My internet research at the time convinced me it was heartburn, most likely from overindulging in processed carbohydrates and chocolate. Waiting it out at home was preferable to sitting in an emergency room for hours, and I never thought to mention it to anyone. It only occurred to me that this could have been a sign of ovarian cancer after 13 months of racking my brain trying to think of symptoms I missed. 

Had my belly button saved my life?



Almost a year after completing chemotherapy, the author waits in the hospital lobby, masked and by herself, as she did for most of her cancer treatment.

If my cancer hadn’t found its way out of my body through my navel, it probably would not have been discovered until after it disrupted other essential organs like my liver, kidneys or lungs. It could have been a death sentence. 

When I met my gynecologic oncologist over videoconference, she told me, “Ovarian cancer isn’t curable, but it is treatable.”

My treatment began with three chemotherapy infusions, making my hair fall out, before we discovered that I had a rare subtype called low-grade serous ovarian cancer, which often does not respond to chemotherapy. My gynecologic oncologist said, “The chemotherapy didn’t work as well as we hoped.”

I had to clarify, “You mean it didn’t work at all.”

In June 2020, my surgeon removed my ovaries, fallopian tubes, uterus, omentum, cervix, and 10 inches of colon because (surprise!) one of the ovarian tumors had perforated my colon. She removed all the cancer she could see, and my blood work following surgery showed lowered levels of CA-125 as well as another tumor marker called human epididymis protein 4 (HE4). Follow-up CT scans have shown no evidence of residual disease.

A common thing for people to ask at this point is, “So you’re good now?”

Ovarian cancer is considered a chronic illness. I am likely to have a recurrence eventually. Even with the removal of all those organs, the cancer can come back elsewhere. But I don’t feel any closer to dying than I was a year ago. If it comes back, by the time it comes back, I hope ovarian cancer research will have led to treatment for all future expressions of my cancer.



The author, second from left, featured on a billboard in London’s Piccadilly Circus on World Ovarian Cancer Day 2021, beside others who share her low-grade serous ovarian cancer diagnosis.

The ribbon for ovarian cancer is teal. I dyed my newborn cap of hair teal and painted my nails to match before a September follow-up with my medical oncologist. The nurse who took my vitals complimented the coordination. “Thanks,” I said. “Ovarian Cancer Awareness Month.” 

She paused in her disinfecting of the pulse oximeter and gave me a second look. “Why didn’t we know that it’s Ovarian Cancer Awareness Month?”

Maybe for the same reason I didn’t realize I had ovarian cancer, even though I’d been to an awareness walk. Ovarian cancer is a sneaky bitch.

Since my diagnosis, when I tell my friends that a Pap smear cannot detect ovarian cancer, I also give them the rundown of the symptoms to watch for.

“I have all of those,” they usually say.

I asked my gynecologic oncologist what they should do. Should they demand a CA-125 blood test and abdominal ultrasound? No, she said. They should tell their doctors about their symptoms and ask, “Do you think it could have something to do with my ovaries?”

Then she told me that early screening does not improve ovarian cancer survival rates. That took me some time to wrap my head around. My understanding is that it doesn’t necessarily matter when we detect ovarian cancer if we don’t have a way to cure it.

Not only do we need the equivalent of a Pap smear for our ovaries, we also need more research to find a cure.

Kari Neumeyer is a writer and editor in the Pacific Northwest. When she’s not writing about cancer, she writes about dogs and salmon. She is working on a memoir about her ovarian cancer diagnosis and treatment. Her first memoir, “Bark and Lunge: Saving My Dogs from Training Mistakes,” was published in 2014. She has a master’s degree in journalism from Northwestern University’s Medill School.

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