Tag Archives: Newborns

Gaza: Palestinians call for evacuation of patients, newborns from largest hospital – The Associated Press

  1. Gaza: Palestinians call for evacuation of patients, newborns from largest hospital The Associated Press
  2. Israel shows alleged Hamas ‘armory’ under children’s hospital in Gaza. Local health officials dismiss the claims CNN
  3. Hamas has command node under Al-Shifa hospital, US official says CNN
  4. Stop pretending hospital peril is all on Israel, Joe, and call out Hamas’ central role in endangering civilians New York Post
  5. The Guardian view on Gaza’s casualties: mounting calls for a ceasefire must be heeded The Guardian
  6. View Full Coverage on Google News

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Woman pleads guilty to manslaughter decades after a dog found her newborn’s body in Maine gravel pit – CNN

  1. Woman pleads guilty to manslaughter decades after a dog found her newborn’s body in Maine gravel pit CNN
  2. Mother pleads guilty in 1985 cold case death of baby girl who was found and taken home by Siberian Husky Law & Crime
  3. Mother pleads guilty to killing infant found dead in gravel pit 37 years ago New York Daily News
  4. Woman pleads guilty in baby’s death nearly 4 decades after dog found body of newborn girl and carried her back to its home CBS News
  5. Abandoned baby’s body was brought home by dog in 1985, cops say. Now mom pleads guilty Yahoo News
  6. View Full Coverage on Google News

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Twins Diagnosed with Same Rare Eye Cancer as Newborns: ‘Tomorrow Isn’t Promised’

At only 10 days old, Eve Oakley experienced a medical crisis, underwent emergency surgery and spent about six months in the hospital. During an eye exam, a doctor noticed tumors in Eve’s eye. They diagnosed her with retinoblastoma, a cancer in the retina. A few days later, Ella, Eve’s twin, was diagnosed with the same cancer.

The Oakley family has faced many challenges as their twins, now 4, continue to live with cancer, off and on, but they want to raise awareness and offer optimism to others.

“I live a life full of hope for them, and I live a life (knowing) tomorrow isn’t promised,” Maryann Oakley, 43, of Marysville, Pennsylvania, told TODAY. “I’m making memories for them as much as possible because I feel like I’ve lost of lot of time. … But in between those scary times, it’s just making sure that they’re happy.”

Surprise twin pregnancy and scary diagnosis

When Maryann Oakley was pregnant, she and her husband felt stunned to learn she was carrying fraternal twins. At one point, it seemed as if only one twin might survive, but they both developed and the pregnancy then seemed healthy. At 37 weeks pregnant, Oakley delivered the girls via Cesarean-section.

“They only stayed in the hospital for about the standard three days. They weighed 5 pounds roughly when they were born, and they had jaundice,” Oakley recalled. “We thought that was the hardest part.”

Around New Year’s Eve 2017, about 10 days after the girls were born, Eve started behaving unusually.

“She was not eating, and she was just screaming,” her mom recalled. “We just knew something was wrong.”

They took Eve to the local hospital, where her vital signs dropped and her skin turned gray. Staff began rushing to treat her.

“They thought it was meningitis,” Oakley said. “She was hooked up to a million things. She was just wailing in this pain. It wasn’t like a normal baby.”

They next day doctors performed exploratory surgery on her and discovered she had a twisted bowel, the cause of her symptoms. Doctors removed part of her bowel and created an ostomy, an opening in the body that allows feces to pass into an external bag. While Eve was recovering, she went into cardiac arrest.

“Everything was so foggy. It was scary,” Oakley said. “They were using these medications, trying to bring her back. I could hear them screaming, ‘Give her more. Give her more,’ trying to get her stable.”

Soon after, Eve went into septic shock, her kidneys and liver were failing, and she was urinating blood. She started having seizures.

During an eye exam with her eyes dilated, doctors noticed tumors in her left eye, a sign of retinoblastoma, where cancer cells form in the tissue of the retina.

Retinoblastoma is the most common type of eye cancer in children, representing 2% of all childhood cancers, according to the American Cancer Society. Only 200 to 300 pediatric cases are diagnosed every year. Infants and young kids are most likely to get it, and it’s rare in children over 6. About 90% of U.S. children with retinoblastoma are cured, but this stat drops if the cancer spreads outside the eye. Retinoblastoma can lead to blindness and other vision problems.

Finding the right care

The hospital where Eve was didn’t specialize in retinoblastoma, but they needed to her to be stable before sending her elsewhere. Meanwhile, doctors recommended Ella also get checked.

“Ella was diagnosed (with retinoblastoma) probably just a couple days after Eve,” Oakley said. “There (was) a lot going on.”

A twin being diagnosed with cancer increases the likelihood that the other one will develop the same or another type of cancer, a 2016 study in JAMA found. The risk is higher in identical twins than it is in fraternal twins. The study looked at data on 3,316 sets of twins where both developed cancer; of these, 38% of identical twins and 26% of fraternal twins developed the same cancer.

Ella started chemotherapy immediately at Children’s Hospital of Philadelphia. When Eve was strong enough, she was flown to the hospital so that when she recovered, she could start chemotherapy, too. Oakley struggled to process that both her newborn daughters had cancer.

“Everything went so fast,” she said. “You’re just going through the motions to make sure they get the best treatment.”

Eve’s health was more precarious, so she stayed in the hospital, a two and a half hour drive from home, while Ella went to outpatient treatment. Eve was on life support for a while, and her parents took turns tending to her or her sister. Every day, either Mom or Dad stayed in the hospital with Eve; the other took Ella to appointments.

Eventually, Ella started experiencing chemo side effects.

“She was sick for her first round of chemotherapy. Every time she would move, it would be like screaming. It’s awful,” Oakley said. “It was six days that Ella was sick on her first round.”

When Eve started chemotherapy, she also became sick, like Ella, but because she was in patient, it was easier to manage. She did endure several infections and a blood clot, though.

More health challenges

By June 2018, both girls were home and done with treatment. But in August 2018, Ella relapsed. “It was a small tumor. They were able to treat it with laser radiation therapy,” Oakley said. “That was good.”

Even though Ella’s been stable since August 2018, she’s considered “high risk for relapse” because retinoblastoma develops as the eyes grow, Oakley explained. Ella still has “tiny” tumors in both eyes, but they’ve shrunk with treatment, so the family hopes they’re “dead.”

Also around the summer of 2018, Eve had her bowels reconnected so she no longer needed the ostomy. To this day, she has short bowel syndrome and some vitamin deficiencies from it, and her blood pressure is still “dangerously high” because she experienced kidney failure, Oakley said. Eve’s kidneys still need time to heal.

The family was thrown another curveball when Eve relapsed in March 2022. She was treated, but in November 2022, she relapsed again and started cryotherapy, a treatment that uses extreme cold to destroy cancer cells, according to Cancer Research UK. The Oakleys recently learned one of Eve’s tumors has started growing again.

“Eve also has a lot going on with the high blood pressure, the history of seizures, so we have to keep an eye on that, and the short gut syndrome,” Oakley said. “She’s at risk for this gut to twist again and the same thing happening.”

Eve also has hearing loss and mostly signs to communicate. Still, that doesn’t stop her from enjoying life.

Offering normalcy in the middle of illness

Eve is adventurous and boisterous. She’d be the first to line up to ride a rollercoaster.

“She’s outgoing and fearless,” Oakley said. “She has very little speech, but she communicates with sign language and other ways.”

Ella is “more timid” and needs a lot more love and support from her parents. While Oakley tries to enjoy fun activities with her children, the cost sometimes prohibits them from doing things. When organizations offer free tickets, Oakley tries to get them so the girls can do some of the same activities that their friends do.

“There’s a farm probably about 15 minutes from here that they love and that’s inexpensive,” Oakley said. “They pet the animals, play in a big sandbox.”

Oakley shares the twins’ story on social media to raise awareness of childhood cancer. Even when things feel tough, she tries to stay upbeat.

“Never give up. We have been dealt a bad hand of cards,” Oakley said. “I’m just trying really to do something with it to help others be aware that childhood cancer does exist.”

This article was originally published on TODAY.com

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RSV: Orange County declares health emergency due to viral infections causing rise in pediatric hospitalizations, ER visits

Orange County has declared a health emergency over what officials call rapidly spreading viral infections that are leading to a record number of pediatric hospitalizations.

The OC Health Care Agency on Monday said daily emergency room visits are also on the rise in the county. There is no vaccine against RSV, a common respiratory virus that creates cold-like symptoms, but the county wants people to be up to date on COVID-19 and flu shots.

“Following preventive measures, including remaining up to date with other vaccinations such as flu and COVID-19, can help reduce the severity of disease and can help reduce the burden on hospitals this fall and winter,” Dr. Regina Chinsio-Kwong, County Health Officer and HCA’s Chief Medical Officer, said in a statement. “Our best shot at protecting ourselves and our children from respiratory illnesses continues to be the same things we practiced throughout the pandemic including the use of masks when indoors around others and staying home when you are sick.”

Additionally, a Proclamation of Local Emergency was declared, which allows Orange County to access state and federal resources to combat the spread.

Health officials are warning parents to look out for symptoms such as rapid breathing, head-bopping, lips turning blue or kids tugging at their rib cage. They also say parents and caregivers should keep young children with respiratory illnesses out of childcare, even if they have tested negative for COVID.

One local doctor told Eyewitness News younger children are more at risk for the respiratory illness.

“Their lungs aren’t as developed as our older children’s lungs are and that’s why we worry about these viruses and this inflammation affecting their lungs moreso. And that’s why they have the symptoms such as wheezing and breathing fast and respiratory stress,” said Dr. Rishma Chand with Dignity Health and Northridge Hospital.

New research shows vaccinating pregnant women helped protect their newborns from RSV, raising hopes that vaccines against the virus may finally be getting close after decades of failure.

Pfizer announced Tuesday that a large international study found vaccinating moms-to-be was nearly 82% effective at preventing severe cases of RSV in their babies’ most vulnerable first 90 days of life. At age 6 months, the vaccine still was proving 69% effective against serious illness – and there were no signs of safety problems in mothers or babies.

The vaccine quest isn’t just to protect infants. RSV is dangerous for older adults, too, and both Pfizer and rival GSK recently announced that their competing shots also proved protective for seniors.

None of the findings will help this year when an early RSV surge already is crowding children’s hospitals. But they raise the prospect that one or more vaccines might become available before next fall’s RSV season.

The Associated Press contributed to this report.

Copyright © 2022 KABC Television, LLC. All rights reserved.



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FDA clears whooping cough vaccine for use during pregnancy to protect newborns

Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, August 29, 2020.

Andrew Kelly | Reuters

The Food and Drug Administration on Friday approved a vaccine for use in the third trimester of pregnancy to prevent whooping cough in newborn infants.

The vaccine, called Boostrix, is made by GlaxoSmithKline. It is the first vaccine the FDA has approved to prevent a disease in young infants by giving the shot to their mothers during pregnancy, said Dr. Peter Marks, the agency’s chief vaccine official.

The vaccine, which is administered as a single dose, was 78% effective in preventing whooping cough in newborns when given to mothers during the third trimester, according to data evaluated by the FDA. No side effects on the pregnancy, fetus or newborn were observed.

The most common side effects for people who receive the vaccine are pain at the injection site, headache and fatigue.

Pertussis, more commonly known as whooping cough, is a highly contagious respiratory disease that can lead to serious health complications in babies. Infants younger than two months are not old enough to receive protection through the normal childhood vaccination series for the disease.

The vaccine allows mothers to protect their newborns by getting the shot while they are pregnant. While whooping cough can affect all age groups, most cases of hospitalization and death occur infants younger than two months old, according to FDA.

The FDA had previously approved Boostrix for use during pregnancy to protect the mother against disease, but had not cleared it specifically to prevent whooping cough in newborns. The vaccine was first approved in 2005 to protect people ages 10 to 18 years old against whooping cough and then later for everyone ages 19 and older.

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Post-Roe, Conservatives Promote Way to Give Up Newborns Anonymously

The Safe Haven Baby Box at a firehouse in Carmel, Ind., looked like a library book drop. It had been available for three years for anyone who wanted to surrender a baby anonymously.

No one had ever used it, though, until early April. When its alarm went off, Victor Andres, a firefighter, opened the box and found, to his disbelief, a newborn boy wrapped in towels.

The discovery made the local TV news, which praised the courage of the mother, calling it “a time for celebration.” Later that month, Mr. Andres pulled another newborn, a girl, from the box. In May, a third baby appeared. By summer, three more infants were left at baby box locations throughout the state.

The baby boxes are part of the safe haven movement, which has long been closely tied to anti-abortion activism. Safe havens offer desperate mothers a way to surrender their newborns anonymously for adoption, and, advocates say, avoid hurting, abandoning or even killing them. The havens can be boxes, which allow parents to avoid speaking to anyone or even being seen when surrendering their babies. More traditionally, the havens are locations such as hospitals and fire stations, where staff members are trained to accept a face-to-face handoff from a parent in crisis.

All 50 states have safe haven laws meant to protect surrendering mothers from criminal charges. The first, known as the “Baby Moses” law, was passed in Texas in 1999, after a number of women abandoned infants in trash cans or dumpsters. But what began as a way to prevent the most extreme cases of child abuse has become a broader phenomenon, supported especially among the religious right, which heavily promotes adoption as an alternative to abortion.

Over the past five years, more than 12 states have passed laws allowing baby boxes or expanding safe haven options in other ways. And safe haven surrenders, experts in reproductive health and child welfare say, are likely to become more common after the Supreme Court’s decision to overturn Roe v. Wade.

During oral arguments in the case, Dobbs v. Jackson Women’s Health Organization, Justice Amy Coney Barrett suggested that safe haven laws offered an alternative to abortion by allowing women to avoid “the burdens of parenting.” In the court’s decision, Justice Samuel A. Alito Jr. cited safe haven laws as a “modern development” that, in the majority’s view, obviated the need for abortion rights.

But for many experts in adoption and women’s health, safe havens are hardly a panacea.

To them, a safe haven surrender is a sign that a woman fell through the cracks of existing systems. They may have concealed their pregnancies and given birth without prenatal care, or they may suffer from domestic violence, drug addiction, homelessness or mental illness.

The adoptions themselves could also be problematic, with women potentially unaware that they are terminating parental rights, and children left with little information about their origins.

If a parent is using a safe haven, “there’s been a crisis and the system has already in some way failed,” said Ryan Hanlon, president of the National Council for Adoption.

Safe haven surrenders are still rare. The National Safe Haven Alliance estimates that 115 legal surrenders took place in 2021. In recent years, there have been over 100,000 domestic adoptions annually, and more than 600,000 abortions. Studies show that the vast majority of women denied an abortion are uninterested in adoption and go on to raise their children.

But the safe haven movement has become much more prominent, in part because of a boost from a charismatic activist with roots in anti-abortion activism, Monica Kelsey, founder of Safe Haven Baby Boxes.

With Ms. Kelsey and allies lobbying across the country, states like Indiana, Iowa and Virginia have sought to make safe haven surrenders easier, faster and more anonymous — allowing older babies to be dropped off, or allowing relinquishing parents to leave the scene without speaking to another adult or sharing any medical history.

Some who work with safe haven children are concerned about the baby boxes, in particular. There are now more than 100 across the country.

“Is this infant being surrendered without coercion?” asked Micah Orliss, director of the Safe Surrender Clinic at Children’s Hospital Los Angeles. “Is this a parent who is in a bad spot and could benefit from some time and discussion in a warm handoff experience to make their decision?”

Ms. Kelsey is a former medic and firefighter, and an adoptee who says she was abandoned at birth by her teenage mother, who had been raped.

She first encountered a baby “safe” — a concept dating back to medieval Europe — on a 2013 trip to a church in Cape Town, South Africa, where she was on a pro-abstinence speaking tour.

She returned home to Indiana to found a nonprofit, Safe Haven Baby Boxes, and installed her first baby box in 2016.

To use one of Ms. Kelsey’s boxes, a parent pulls open a metal drawer to reveal a temperature-controlled hospital bassinet. Once the baby is inside and the drawer is closed, it locks automatically; the parent cannot reopen it. An alarm is triggered and the facility’s staff members can access the bassinet. The box also sends out a 911 call. Twenty-one babies have been left in the boxes since 2017, and the average amount of time a child is inside the box is less than two minutes, Ms. Kelsey said.

She has raised money to put up dozens of billboards advertising the safe haven option. The advertisements feature a photo of a handsome firefighter cradling a newborn, and the Safe Haven Baby Box emergency hotline number.

Ms. Kelsey said she was in contact with legislators across the country who wanted to bring the boxes to their regions, and predicted that within five years, her boxes would be in all 50 states.

“We can all agree a baby should be placed in my box and not in a dumpster to die,” she said.

Because of the anonymity, there is limited information about the parents who use safe havens. But Dr. Orliss, of the Los Angeles safe haven clinic, performs psychological and developmental evaluations on some 15 such babies annually, often following them through their toddler years. His research found that more than half the children have health or developmental issues, often stemming from inadequate prenatal care. In California, unlike in Indiana, safe haven surrenders must be done face-to-face, and parents are given an optional questionnaire on medical history, which often reveals serious problems such as drug use.

Still, many children do well. Tessa Higgs, 37, a marketing manager in southern Indiana, adopted her 3-year-old daughter, Nola, after the girl was dropped off at a safe haven just hours after her birth. Ms. Higgs said the biological mother had called the Safe Haven Baby Box hotline after seeing one of the group’s billboards.

“From day one, she has been so healthy and happy and thriving and exceeding all developmental milestones,” Ms. Higgs said of Nola. “She’s perfect in our eyes.”

For some women seeking help, the first point of contact is the Safe Haven Baby Box emergency hotline.

That hotline, and another maintained by the Safe Haven National Alliance, tell callers where and how they can legally surrender children, along with information about the traditional adoption process.

Safe haven groups say they inform callers that anonymous surrenders are a last resort, and give out information on how to keep their babies, including ways to get diapers, rent money and temporary child care.

“When a woman is given options, she will choose what’s best for her,” Ms. Kelsey said. “And if that means that in her moment of crisis she chooses a baby box, we should all support her in her decision.”

But Ms. Kelsey’s hotline does not talk about the legal time constraints for reunifying with the baby unless callers ask for it, she said.

In Indiana, which has the majority of baby boxes, state law does not specify a timeline for terminating birth parents’ rights after safe haven surrenders, or for adoption. But according to Don VanDerMoere, the prosecutor in Owen County, Ind., who has experience with infant abandonment laws in the state, biological families are free to come forward until a court terminates parental rights, which can occur 45 to 60 days after an anonymous surrender.

Because these relinquishments are anonymous, they typically lead to closed adoptions. Birth parents are unable to select the parents, and adoptees are left with little to no information about their family of origin or medical history.

Mr. Hanlon, of the National Council for Adoption, pointed to research showing that over the long term, birth parents feel more satisfied about giving up their children if biological and adoptive families maintain a relationship.

And in safe haven cases, if a mother changes her mind, she must prove to the state that she is fit.

According to Ms. Kelsey, since her operation began, two women who said they had placed their infants in boxes have tried to reclaim custody of their children. Such cases can take months or even years to resolve.

Birth mothers are also not immune from legal jeopardy, and may not be able to navigate the technicalities of each state’s safe haven law, said Lori Bruce, a medical ethicist at Yale.

While many states protect surrendering mothers from criminal prosecution if babies are healthy and unharmed, mothers in severe crisis — dealing with addiction or domestic abuse, for example — may not be protected if their newborns are in some way affected.

The idea of a traumatized, postpartum mother being able to “correctly Google the laws is slim,” Ms. Bruce said.

With the demise of Roe, “we know we are going to see more abandoned babies,” she added. “My concern is that means more prosecutors are going to be able to prosecute women for having unsafely abandoned their children — or not following the letter of the law.”

On Friday, the Indiana governor signed legislation banning most abortions, with slim exceptions.

And the safe haven movement continues apace.

Ms. Higgs, the adoptive mother, has stayed in touch with Monica Kelsey of Safe Haven Baby Boxes. “The day that I found out about Roe vs. Wade, I texted Monica and was like, ‘Are you ready to get even busier?’”

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Senegal: Eleven newborns die in hospital fire

“I just learned, with pain and consternation, the death of 11 newborn babies,” Sall said in a tweet.

“I express my profound compassion to their mothers and their families,” he added. 

CNN has contacted the hospital, but has not yet heard back. 

In a statement later Thursday, the country’s health ministry said an emergency response plan had been put in place and “arrangements are being made for the assistance of the families of the victims.”

The ministry’s statement added that Health Minister Abdoulaye Diouf Sarr, who is attending the World Health Assembly in Geneva had cut short his trip and would return to Senegal today.

Senegalese Minister of Regional Planning and Local Government, Cheikh Bamba Dièye, described the fatal incident as “horrific and unacceptable” while urging a probe of the country’s health systems.

“I am appalled by the horrific and unacceptable death of 11 newborn babies in Tivaoune. The recurrence of tragedies in our hospitals reminds us of the obligation to thoroughly review the quality of service in our hospitals. My deepest condolences to the families,” he said in a Twitter post.



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Exercising in pregnancy ‘can boost baby’s lungs’ and helps newborns stave off asthma, research shows

Exercising in pregnancy ‘can boost baby’s lungs’: Regular workouts for expectant mothers helps newborns stave off asthma, research suggests

  • Study found that the children of women who did little exercise during pregnant were twice as likely to have poor lung function
  • Experts said the findings showed the importance of mothers-to-be remaining fit
  • The exercise helps the newborns develop stronger lungs and stave off athsma










Exercising regularly in pregnancy helps newborns develop stronger lungs and stave off asthma, research shows.

Scientists asked more than 800 women how active they were during pregnancy, then tested the lung function of their babies at three months old.

The study, by researchers at the University of Oslo, found that the children of women who did little exercise were twice as likely to have poor lung function.

Experts said the findings showed the importance of mothers-to-be remaining fit, both for their own health and their child’s.

Exercising regularly in pregnancy helps newborns develop stronger lungs and stave off asthma, research shows (file image)

The babies’ lung function was assessed by measuring normal breathing in calm, awake infants. This was done by holding a face mask over their nose and mouth, and recording the flow and volume of air breathed in and out. 

Some 8.6 per cent of babies born to inactive mothers had the lowest lung function, compared to just 4.2 per cent of the babies born to active mothers.

Lead author Dr Hrefna Katrin Gudmundsdottir said: ‘Previous studies have shown that individuals with low lung function in infancy have higher risk of asthma, other obstructive lung diseases, and lower lung function later in life.

‘If being physically active during pregnancy could reduce the risk of impaired infant lung function, it would be a simple, low-cost way to improve the respiratory health of offspring.’ 

The study, by researchers at the University of Oslo, found that the children of women who did little exercise were twice as likely to have poor lung function 

Professor Jonathan Grigg, head of paediatric respiratory and environmental medicine at Queen Mary University of London, said: ‘There is much that we know already about the importance for expectant mothers of staying physically fit and active, but far less is known about the impact of this on their babies.

‘This study offers a fascinating hint that increased physical activity of mothers is associated with better lung function in their babies.’ The study’s findings were presented at the virtual European Respiratory Society International Congress.

The NHS urges mothers-to-be to keep up their normal daily physical activity and exercise for as long as they feel comfortable.

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Sugars From Human Breast Milk Could Help Treat and Prevent Infections in Newborns

Oligosaccharides in breast milk could help treat or prevent bacterial infections in newborns and adults.

Bacteria known as group B Streptococcus (GBS) are a common cause of blood infections, meningitis, and stillbirth in newborns. Although GBS infections can often be treated or prevented with antibiotics, the bacteria are becoming increasingly resistant. Now, researchers have discovered that human milk oligosaccharides (HMOs) – short strings of sugar molecules abundant in breast milk – can help prevent GBS infections in human cells and tissues and in mice. Someday, HMOs might be able to replace antibiotics for treating infections in infants and adults, they say.

The researchers will present their results today at the fall meeting of the American Chemical Society (ACS). ACS Fall 2021 is a hybrid meeting being held virtually and in-person August 22-26, and on-demand content will be available August 30-September 30. The meeting features more than 7,000 presentations on a wide range of science topics.

“Our lab has previously shown that mixtures of HMOs isolated from the milk of several different donor mothers have antimicrobial and antibiofilm activity against GBS,” says Rebecca Moore, who is presenting the work at the meeting. “We wanted to jump from these in vitro studies to see whether HMOs could prevent infections in cells and tissues from a pregnant woman, and in pregnant mice.” Moore is a graduate student in the labs of Steven Townsend, Ph.D., at Vanderbilt University and Jennifer Gaddy, Ph.D., at Vanderbilt University Medical Center.

According to the U.S. Centers for Disease Control and Prevention, about 2,000 babies in the U.S. get GBS each year, and 4-6% of them die from it. The bacteria are often transferred from mother to baby during labor and delivery. An expectant mother who tests positive for GBS is usually given intravenous antibiotics during labor to help prevent early-onset infections, which occur during the first week of life. Interestingly, the incidence of late-onset infections (which happen from one week to three months after birth) is higher in formula-fed than breastfed infants, which suggests that factors in breast milk could help protect against GBS. If so, the sugars could perhaps replace antibiotics, which, in addition to killing beneficial bacteria, are becoming less effective because of the rise in antibiotic resistance.

The researchers studied the effects of combined HMOs from several mothers on GBS infection of placental immune cells (called macrophages) and of the gestational membrane (the sac surrounding the fetus). “We found that HMOs were able to completely inhibit bacterial growth in both the macrophages and the membranes, so we very quickly turned to looking at a mouse model,” Moore says. They examined whether HMOs could prevent a GBS infection from spreading through the reproductive tract of pregnant mice. “In five different parts of the reproductive tract, we saw significantly decreased GBS infection with HMO treatment,” Moore notes.

To figure out which HMOs and other oligosaccharides have these antimicrobial effects and why, the researchers set up an artificial two-species microbiome with GBS and the beneficial Streptococcus salivarius species growing in a tissue culture plate, separated by a semi-permeable membrane. Then, the researchers added oligosaccharides that are commonly added to infant formula, called galacto-oligosaccharides (GOS), which are derived from plants. In the absence of the sugar, GBS suppressed the growth of the “good” bacteria, but GOS helped this beneficial species grow. “We concluded that GBS is producing lactic (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "https://connect.facebook.net/en_US/sdk.js#xfbml=1&version=v2.6"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk'));

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Study says COVID-19 vaccines provide protection for pregnant and lactating women — and their newborns

ATLANTA (CNN) — The Pfizer/BioNTech and Moderna COVID-19 vaccines are effective in pregnant and lactating women, who can pass protective antibodies to newborns, according to research published Thursday in the American Journal of Obstetrics and Gynecology.

Researchers at Massachusetts General Hospital, Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard looked at 131 women who received either the Pfizer/BioNTech or Moderna COVID-19 vaccine. Among the participants, 84 were pregnant, 31 were lactating and 16 were not pregnant. Samples were collected between December 17, 2020, and March 2, 2021.

The vaccine-induced antibody levels were equivalent in pregnant and lactating women, compared to nonpregnant women. The antibody levels were “strikingly higher” than those resulting from coronavirus infection during pregnancy, the team noted.

“These vaccines seem to work incredibly effectively in these women,” said one of the researchers, Galit Alter, a professor of medicine at the Ragon Institute.

In addition, the team found that women passed protective antibodies to their newborns, measured in breast milk and the placenta.

“Nearly all the moms were getting a pretty decent level of antibodies to their babies,” said Alter, who added that additional research is needed to understand how long those protective antibodies last in newborns.

Participants used the U.S. Centers for Disease Control and Prevention’s V-safe tool, which allows people who have received a COVID-19 vaccine to track their reaction. Alter said they found no evidence of more side effects or more intense side effects in pregnant and lactating women than in the general population.

While the team found similar antibody levels in women vaccinated with both vaccines, Alter said they found higher levels of IgA antibodies in pregnant women who received the Moderna vaccine. She said this particular type of antibody may be transferred more efficiently to babies, for a longer period of time.

“There is some reason to think that having higher levels of IgA immunity might be more protective,” Alter noted. She said additional research into this finding could help inform policy decisions about which vaccines are used for pregnant populations.

Recent research similarly found that mRNA vaccines elicit antibodies in pregnant women that can be transferred to their babies, though this is the largest study on vaccines in pregnant women, to date. Pregnant and lactating women were not included in the initial clinical trials of the vaccines.


This is an urgent need, because we’re not only protecting one person in this vaccine effort, we’re protecting two people at the same time.

–Galit Alter, a professor of medicine at the Ragon Institute


With no data to look to help inform pregnant women’s decisions about getting vaccinated against COVID-19, Alter said researchers and new and expectant mothers — particularly health care workers — stepped up to fill the void.

“MGH and Brigham started to talk to the health care workers that were eligible for vaccination, that were also pregnant, and they created a study to empower pregnant women with the ability to track their responses, but to also develop data that could essentially help the entire globe approach vaccination and pregnancy for the first time in this collective kind of way.

“It was really just a force to be reckoned with, both from the OB-GYN/provider perspective, but also from the community,” said Alter. “It was inspiring.”

According to the CDC, pregnant people with COVID-19 are at increased risk for severe illness and may be at increased risk for adverse outcomes, like preterm birth. The CDC says it hopes to study vaccine safety in around 13,000 pregnant people for each of the three authorized coronavirus vaccines. The agency will use a specific V-safe pregnancy registry, which had enrolled about 3,612 pregnant women, as of March 22.

“This is an urgent need, because we’re not only protecting one person in this vaccine effort, we’re protecting two people at the same time,” said Alter.

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