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Shock Discovery – Humans First Interbred with Neanderthals 250000 Years Ago – Ancient Origins

  1. Shock Discovery – Humans First Interbred with Neanderthals 250000 Years Ago Ancient Origins
  2. Neanderthals Interbred With An Unknown Lineage Of Modern Humans Long Ago IFLScience
  3. Neanderthals built their own fireplaces where they used to cook food on a regular basis, similar to modern hum Business Insider India
  4. Human interbreeding contributed 6% to Neanderthal genome, finds study Interesting Engineering
  5. Neanderthals Were As Smart As Modern Humans and Used Fire to Cook Food on Hearths! | Weather.com The Weather Channel
  6. View Full Coverage on Google News

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Neanderthals hunted and butchered giant elephants

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Some 125,000 years ago, enormous elephants that weighed as much as eight cars each roamed in what’s now northern Europe.

Scientifically known as Palaeoloxodon antiquus, the towering animals were the largest land mammals of the Pleistocene, standing more than 13 feet (4 meters) high. Despite this imposing size, the now-extinct straight-tusked elephants were routinely hunted and systematically butchered for their meat by Neanderthals, according to a new study of the remains of 70 of the animals found at a site in central Germany known as Neumark-Nord, near the city of Halle.

The discovery is shaking up what we know about how the extinct hominins, who existed for more than 300,000 years before disappearing about 40,000 years ago, organized their lives. Neanderthals were extremely skilled hunters, knew how to preserve meat and lived a more settled existence in groups that were larger than many scholars had envisaged, the research has suggested.

A distinct pattern of repetitive cut marks on the surface of the well-preserved bones — the same position on different animals and on the left and right skeletal parts of an individual animal — revealed that the giant elephants were dismembered for their meat, fat and brains after death, following a more or less standard procedure over a period of about 2,000 years. Given a single adult male animal weighed 13 metric tons (twice as much as an African elephant), the butchering process likely involved a large number of people and took days to complete.

Stone tools have been found in northern Europe with other straight-tusked elephant remains that had some cut marks. However, scientists have never had clarity on whether early humans actively hunted elephants or scavenged meat from those that died of natural causes. The sheer number of elephant bones with the systematic pattern of cut marks put this debate to rest, said the authors of the study published Wednesday in the journal Science Advances.

The Neanderthals likely used thrusting and throwing spears, which have been found at another site in Germany, to target male elephants because of their larger size and solitary behavior, said study coauthor Wil Roebroeks, a professor of Paleolithic archaeology at Leiden University in Germany. The demographics of the site skewed toward older and male elephants than would be expected had the animals died naturally, according to the study.

“It’s a matter of immobilizing these animals or driving them into muddy shores so that their weight works against them,” he said. “If you can immobilize one with a few people and corner them into an area where they get stuck. It’s a matter of finishing them off.”

What was most startling about the discovery was not that Neanderthals were capable of hunting such large animals but that they knew what to do with the meat, said Britt M. Starkovich, a researcher at the Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tübingen in Germany, in commentary published alongside the study.

“The yield is mindboggling: more than 2,500 daily portions of 4,000 calories per portion. A group of 25 foragers could thus eat a straight-tusked elephant for 3 months, 100 foragers could eat for a month, and 350 people could eat for a week,” wrote Starkovich, who was not involved in the research.

“Neanderthals knew what they were doing. They knew which kinds of individuals to hunt, where to find them, and how to execute the attack. Critically, they knew what to expect with a massive butchery effort and an even larger meat return.”

The Neanderthals living there likely knew how to preserve and store meat, perhaps through the use of fire and smoke, Roebroeks said. It’s also possible that such a meat bonanza was an opportunity for temporary gatherings of people from a larger social network, said study coauthor Sabine Gaudzinski-Windheuser, a professor of prehistoric and protohistoric archaeology at the Johannes Gutenberg-University in Mainz, Germany.

She explained the occasion could perhaps have served as a marriage market. An October 2022 study based on ancient DNA from a small group of Neanderthals living in what’s now Siberia suggested that women married outside their own community, noted Gaudzinski-Windheuser, who is also director of the Monrepos Archaeological Research Centre and Museum of Human Behavioural Evolution in Neuwied.

“We don’t see that in the archaeological record but I think the real benefit of this study is that now everything’s on the table,” she said.

Scientists had long thought that Neanderthals were highly mobile and lived in small groups of 20 or less. However, this latest finding suggested that they may have lived in much bigger groups and been more sedentary at this particular place and time, when food was plentiful and the climate benign. The climate at the time — before the ice sheets advanced at the start of the last ice age around 100,000 to 25,000 years ago — would have been similar to today’s conditions.

Killing a tusked elephant would not have been an everyday event, the study found, with approximately one animal killed every five to six years at this location based on the number found. It’s possible, however, that more elephant remains were destroyed as the site is part of a open cast mine, according to the researchers. Other finds at the site suggested Neanderthals hunted a wide array of animals across a lake landscape populated by wild horses, fallow deer and red deer.

More broadly, the study underscores the fact that Neanderthals weren’t brutish cave dwellers so often depicted in popular culture. In fact, the opposite is true: They were skilled hunters, understood how to process and preserve food, and thrived in a variety of different ecosystems and climates. Neanderthals also made sophisticated tools, yarn and art, and they buried their dead with care.

“To the more recognizably human traits that we know Neanderthals had — taking care of the sick, burying their dead, and occasional symbolic representation — we now also need to consider that they had preservation technologies to store food and were occasionally semi sedentary or that they sometimes operated in groups larger than we ever imagined,” Starkovich said.

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Green comet will pass by Earth for first time since Neanderthals roamed Earth

A green comet discovered last March will make its closest approach to Earth this month.

The comet C/2022 E3 (ZTF) was first discovered by astronomers using the wide-field survey camera at California’s Zwicky Transient Facility. 

It was already inside the orbiter of Jupiter.

Since then, it has brightened substantially and is sweeping across the northern constellation Corona Borealis in predawn skies, according to NASA. 

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The planet Jupiter, 1979. Taken from Voyager 1 at 20 million kilometres this pictures shows the Great Red Spot, a storm that has been raging for hundreds of years, and two of Jupiter’s moons – Io over the Red Spot and Europa. 
((Photo by Oxford Science Archive/Print Collector/Getty Images))

The agency notes that it is still too dim to see without a telescope – though an image from December reveals its bright coma, short broad dust tail and faint ion tail.

The comet will be at perihelion, its closest to the sun, on Jan. 12 and at the closest to Earth on Feb. 1. 

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Comet NEOWISE (C/2020 F3) on July 27, 2020, from the Columbia Icefields (Jasper National Park, Alberta) from the Toe of the Glacier parking lot, looking north over Sunwapta Lake, formed by the summer meltwater of Athabasca Glacier. 
((Photo by: Alan Dyer/VW PICS/Universal Images Group via Getty)

NASA notes that the brightness of comets is unpredictable, but that – by then – C/2022 E3 (ZTF) could become only just visible to the eye in night skies.

“Observers in the Northern Hemisphere will find the comet in the morning sky, as it moves swiftly toward the northwest during January. (It’ll become visible in the Southern Hemisphere in early February),” it said. 

This comet isn’t expected to be quite as much of a spectacle as Comet NEOWISE was in 2020.

A Neanderthal man at the human evolution exhibit at the Natural History Museum in London, England, United Kingdom. 
((photo by Mike Kemp/In Pictures via Getty Images Images))

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It has a full orbit of around 50,000 years, according to NASA’s Jet Propulsion Laboratory, meaning that the last time it came so close to Earth was when Neanderthals roamed the planet.

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Comet that hasn’t been seen since the Neanderthals is about to pass Earth again

A comet being described as a “cosmic snowball” will pass by Earth next year for the first time in 50,000 years.

The remarkable sight hasn’t been seen since Neanderthals walked the planet, and astronomers are getting hugely excited for the unique comet to be seen again.

A comet will pass Earth for the first time in 50,000 years. Credit: Pexels

The comet known as C/2022 E3 (ZTF) will make its closest approach to Earth on 1 February, 2023, nearly 12 months on from when scientists first discovered its existence.

Astronomers first spotted the comet’s brighter greenish coma and a yellowy dust tail in March 2022, using a wide-field survey camera at the Zwicky Transient Facility.

At the moment, the comet is currently 117 million miles from Earth and it still has quite a journey to make before it will be at its brightest on 1 February.

The comet needs to reach the Sun, loop around and then head back past our planet.

Astronomers believe we will be able to see the comet, known as C/2022 E3 (ZTF) as early as January 26. Credit: Pexels

And for anyone keen to try and spot it in the sky, it could become visible when its roughly 26 million miles away, with its magnitude predicted to be +6.

Astronomers believe this comet might be the first one seen by the naked eye since the NEOWISE comet two years ago in July 2020.

But while the NEOWISE comet left a long, misty tail in the sky, this comet is most likely to appear as a grey streak across the night sky.

It may be even possible to view it as early as January 26, but will be brighter and easier to see by 1 February.

The comet may also remain visible into the second week of February, but astronomers have predicted that by April, it will be close to the Sun in the sky and be significantly fainter, so will be very hard to find even with a telescope.

It could be the first comet seen to the naked eye since the NEOWISE comet in July 2020. Credit: Pexels

Tania de Sales Marques, an astronomer at the Royal Observatory Greenwich in the United Kingdom, told Newsweek: “It’s notoriously hard to predict the brightness of comets, however, sky watchers everywhere have been keeping track of Comet C/2022 E3 (ZTF) since it was discovered in March 2022, and the current prediction is that it might reach magnitude +6—the limit of what the naked eye can see—or even slightly brighter when it’s at its closest approach to the Earth on the 1st of February.”

She added: “It’s traveling in the general direction of Polaris, the North Star, where we’ll be able to find it in early February. By then, it should be visible throughout the night.”

This comet will be the first naked eye comet since stargazers were able to see NEOWISE in 2020. Credit: Pixabay

Robert Massey, deputy executive director of the U.K. Royal Astronomical Society, told keen comet gazers how to best see the comet E3. He recommended looking on a clear night from a dark site as the comet won’t be the easiest object to find.

Also speaking to Newsweek, he advised: “Binoculars are ideal for beginners trying to find a comet as they’re easy to use, whereas a telescope has a much smaller field of view. If you can see it with binoculars then try with your naked eye.”

Seeing as the comet won’t be back again for another 50,000 years, this might be one of those once-in-a-lifetime chances to catch it, so best get your binoculars ready!

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Comet last seen when Neanderthals existed 50,000 years ago is revealed in a new image

A comet not seen since Neanderthals walked the Earth is set to make a return trip – and astronomers have shared the first detailed image of the ‘cosmic snowball.’

Formally known as C/2022 E3 (ZTF), the comet orbits the sun every 50,000 years and is set to make its closest approach to our planet on February 1, 2023.

E3 was discovered in March, but scientists recently snapped the first detailed photo revealing its brighter greenish coma and a yellowy dust tail.

While the comet is too dim to see without a telescope, it should be visible to the naked eye when it is roughly 26 million miles away.

E3 was discovered in March, but scientists recently snapped the first detailed photo revealing its brighter greenish coma and a yellowy dust tail

In early March, astronomers discovered Comet C/2022 E3 (ZTF) using the wide-field survey camera at the Zwicky Transient Facility. 

Since then, the new long-period comet has brightened substantially and is now sweeping across the northern constellation Corona Borealis in predawn skies. 

The comet is currently 117 million miles from Earth and is set to reach the sun on January 1, loop around and make its closest approach to our planet.

And E3 will be the first comet seen to the naked eye since the NEOWISE comet in July 2020.

However, NEOWISE left a long, misty tail and E3 is likely to appear as a grey streak in the night sky.

E3 should be visible by January 26 but reach its brightest on February 1. 

This comet is not the only cosmic display set for 2023, as the year will kick off with the annual Quadrantids meteor shower and will end with the impressive Geminid meteor shower in December.

The Quadrantid is one of the year’s most spectacular meteor showers, and you do not need specialist equipment to see it.

While the meteor shower technically began today, it will reach its peak on the night of January 3 and the morning of January 4.

It is an above-average shower, which usually sees 40 meteors pass per hour.

At an extreme, however, up to 200 shooting stars can be seen per hour, but that relies on perfect conditions and the ideal spot on Earth. 

And, as 2023 comes to a close, the Geminid meteor shower will light up the sky from December 13 to 14.

The comet is currently 117 million miles from Earth and is set to reach the sun on January 1, loop around and make its closest to our planet

This comet is not the only cosmic display set for 2023, as the year will kick off with the annual Quadrantids meteor shower and will end with the impressive Geminid meteor (pictured) shower in December

The meteors are mainly white but can also be yellow, green, red or blue.

While comets cause most meteor showers, the Geminid meteor shower is unique as the shower is produced as the Earth passes through a trail of debris created by an asteroid known as 3200 Phaethon.

Head to a dark area, away from light pollution, and allow at least 30 minutes for your eyes to adjust to the night sky.

The Geminid meteor shower was first reported in 1862, but it was not until 1983 that scientists determined 3200 Phaethon was the source.

It is called the Geminids because when Earth passes through the debris, it lights up the Castor star in the Gemini constellation.

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Earth Is About To See An Object Last Seen During The Time Of Neanderthals

If you look up into the sky over the next few months, you can see an object last seen when Neanderthals walked the Earth.

On March 2, 2022, astronomers at the Zwicky Transient Facility discovered a comet using a wide-field survey camera. The comet is estimated to complete an orbit of the Sun once every 50,000 years, meaning the last time we saw the comet was in the Upper Paleolithic period, when humans began to expand throughout Asia and Europe.

The comet, dubbed a tongue-rolling “C/2022 E3 (ZTF)”,  is currently too dim to be seen without a telescope. However, it may be possible to see with the naked eye sometime at the end of January and beginning of February 2023.

The comet is currently on its approach to perihelion (its closest approach to the Sun), which will occur on January 12. It will be closest to Earth – known as at perigee – on February 1. Around this point, it may be visible to the naked eye, though Sky at Night point out it would likely look like a smudge of chalk dust on a chalk board rather than the dazzling display put on by comet Neowise.

The comet, first believed to be an asteroid before the coma was observed, was discovered using a telescope that, at 1.2 meters (4 feet), is around the size of Hervé Villechaize, who played evil henchman Nick Nack in James Bond: The Man With The Golden Gun. It will safely pass the Earth at a distance of about 44 million kilometers (27 million miles), or 36,667 million Hervé Villechaizes away.

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Neanderthals went extinct because of sex, not war

Regardless of how they communicated, their encounters led to breeding between both species. How this occurred remains a mystery.

Ancient humans around a campfire.

Was the interbreeding a success?

Whether or not the interbreeding was a success depends on the breeding pair. There is no evidence of Homo sapiens genetics in late Neanderthal genomes from 40-60,000 years ago.

Even though we know that our species interbred with Neanderthals, the genes we have in us today aren’t a result of the interactions that Homo sapiens maintained when they left Africa.

Another interesting finding – the lack of mitochondrial DNA, which is inherited through females point to the evidence that only male Neanderthals and female Homo sapiens could mate.

“We don’t know if the apparent one-way gene flow is because it simply wasn’t happening, that the breeding was taking place but was unsuccessful, or if the Neanderthal genomes we have are unrepresentative. As more Neanderthal genomes are sequenced, we should be able to see whether any nuclear DNA from Homo sapiens was passed on to Neanderthals and demonstrate whether or not this idea is accurate,” added Stringer.

Study Abstract:

Evidence suggests that the Neanderthal and Homo sapiens lineages began diverging about 600,000 years ago, evolving largely separately in Eurasia and Africa after that time. Around 60,000 years ago H. sapiens began a significant emergence from Africa that would lead to a near-global distribution by 10,000 years ago. However, recent research on fossils from Apidima Cave (Greece) suggests that there was an earlier dispersal of our species that reached Europe more than 200,000 years ago, which is consistent with data from ancient DNA suggesting gene flow between the early H. neanderthalensis and H. sapiens lineages during the time span of the later Middle Pleistocene. Additional range expansions of H. sapiens are suggested from western Asian evidence prior to 100,000 years ago, and from China, Sumatra and Australia before the 60,000-year datum. Until recently, there were few other signs of a H. sapiens presence in Europe prior to the Aurignacian expansions that began around 41,000 years ago. However, new data from sites like Zlatý k?? (Czechia), Bacho Kiro Cave (Bulgaria), Grotta del Cavallo (Italy) and Grotte Mandrin (France) indicate that there were pre-Aurignacian dispersals that potentially placed H. sapiens populations alongside the persisting Neanderthals. While some of these populations can be related to later Eurasians, others seem to represent now-extinct lineages of H. sapiens. It is now known from a growing body of genetic data that this co-existence of H. neanderthalensis and H. sapiens was accompanied by bouts of interbreeding between the two species. It is suggested here that a continuing absorption of Neanderthal individuals into H. sapiens groups could have been one of the factors that led to the demise of the Neanderthals.

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DNA of 13 Neanderthals reveals ‘exciting’ snapshot of ancient community | Anthropology

The first snapshot of a Neanderthal community has been pieced together by scientists who examined ancient DNA from fragments of bone and teeth unearthed in caves in southern Siberia.

Researchers analysed DNA from 13 Neanderthal men, women and children and found an interconnecting web of relationships, including a father and his teenage daughter, another man related to the father, and two second-degree relatives, possibly an aunt and her nephew.

All of the Neanderthals were heavily inbred, a consequence, the researchers believe, of the Neanderthals’ small population size, with communities scattered over vast distances and numbering only about 10 to 30 individuals.

Laurits Skov, first author on the study at the Max Planck Institute for Evolutionary Anthropology in Leipzig, said the fact that the Neanderthals were alive at the same time was “very exciting” and implied that they belonged to a single social community.

Neanderthal remains have been recovered from numerous caves across western Eurasia – territory the heavy-browed humans occupied from about 430,000 years ago until they became extinct 40,000 years ago. It has previously been impossible to tell whether Neanderthals found at particular sites belonged to communities or not.

“Neanderthal remains in general, and remains with preserved DNA in particular, are extremely rare,” said Benjamin Peter, a senior author on the study in Leipzig. “We tend to get single individuals from sites often thousands of kilometres, and tens of thousand of years apart.”

In the latest work, researchers including Svante Pääbo, who won this year’s Nobel prize in medicine for breakthrough studies on ancient genomes, examined DNA from the remains of Neanderthals found in the Chagyrskaya cave and nearby Okladnikov cave in the Altai Mountains of southern Siberia.

Neanderthals sheltered in the caves about 54,000 years ago, seeking cover to feast on the ibex, horse and bison they hunted as the animals migrated along the river valleys the caves overlook. Beyond Neanderthal and animal bones, tens of thousands of stone tools were also found.

Writing in the journal Nature, the scientists describe how the ancient DNA points to the Neanderthals living at the same time, with some being members of the same family.

Further analysis revealed more genetic diversity in Neanderthal mitochondria – the tiny battery-like structures found inside cells which are only passed down the maternal line – than in their Y chromosomes, which are passed down from father to son. The most likely explanation, the researchers say, is that female Neanderthals travelled from their home communities to live with male partners. Whether force was involved is not a question DNA can answer, however. “Personally, I don’t think there is particularly good evidence that Neanderthals were much different from early modern humans that lived at the same time,” said Peter.

“We find that the community we study was likely very small, perhaps 10 to 20 individuals, and that the wider Neanderthal populations in the Altai mountains were quite sparse,” Peter said. “Nevertheless, they managed to persevere in a rough environment for hundreds of thousands of years, which I think deserves great respect.”

Dr Lara Cassidy, an assistant professor in genetics at Trinity College Dublin, called the study a “milestone” as “the first genomic snapshot of a Neanderthal community”.

“Understanding how their societies were organised is important for so many reasons,” Cassidy said. “It humanises these people and gives rich context to their lives. But also, down the line if we have more studies like this, it may also reveal unique aspects of the social organisation of our own Homo sapiens ancestors. This is crucial to understanding why we are here today and Neanderthals are not.”

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Neanderthals, humans co-existed in Europe for over 2,000 years: study

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Paris (AFP) – Neanderthals and humans lived alongside each other in France and northern Spain for up to 2,900 years, modelling research suggested Thursday, giving them plenty of time to potentially learn from or even breed with each other.

While the study, published in the journal Scientific Reports, did not provide evidence that humans directly interacted with Neanderthals around 42,000 years ago, previous genetic research has shown that they must have at some point.

Research by Swedish paleogeneticist Svante Paabo, who won the medicine Nobel prize last week, helped reveal that people of European descent — and almost everyone worldwide — have a small percentage of Neanderthal DNA.

Igor Djakovic, a PhD student at Leiden University in the Netherlands and lead author of the new study, said we know that humans and Neanderthals “met and integrated in Europe, but we have no idea in which specific regions this actually happened”.

Exactly when this happened has also proved elusive, though previous fossil evidence has suggested that modern humans and Neanderthals walked the Earth at the same time for thousands of years.

To find out more, the Leiden-led team looked at radiocarbon dating for 56 artefacts — 28 each for Neanderthals and humans — from 17 sites across France and northern Spain.

The artefacts included bones as well as distinctive stone knives thought to have been made by some of the last Neanderthals in the region.

The researchers then used Bayesian modelling to narrow down the potential date ranges.

‘Never really went extinct’

Then they used optimal linear estimation, a new modelling technique they adapted from biological conservation sciences, to get the best estimate for when the region’s last Neanderthals lived.

Djakovic said the “underlying assumption” of this technique is that we are unlikely to ever discover the first or last members of an extinct species.

“For example, we’ll never find the last woolly Rhino,” he told AFP, adding that “our understanding is always broken up into fragments”.

The modelling found that Neanderthals in the region went extinct between 40,870 and 40,457 years ago, while modern humans first appeared around 42,500 years ago.

This means the two species lived alongside each other in the region for between 1,400 and 2,900 years, the study said.

Humans, neanderthals, Denisovan and mystery hominins AFP

During this time there are indications of a great “diffusion of ideas” by both humans and Neanderthals, Djakovic said.

The period is “associated with substantial transformations in the way that people are producing material culture,” such as tools and ornaments, he said.

There was also a “quite severe” change in the artefacts produced by Neanderthals, which started to look much more like those made by humans, he added.

Given the changes in culture and the evidence in our own genes, the new timeline could further bolster a leading theory for the end of the Neanderthals: mating with humans.

Breeding with the larger human population could have meant that, over time, Neanderthals were “effectively swallowed into our gene pool,” Djakovic said.

“When you combine that with what we know now — that most people living on Earth have Neanderthal DNA — you could make the argument that they never really went extinct, in a certain sense.”

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What Makes Your Brain Different From a Neanderthal’s?

Scientists have discovered a glitch in our DNA that may have helped set the minds of our ancestors apart from those of Neanderthals and other extinct relatives.

The mutation, which arose in the past few hundred thousand years, spurs the development of more neurons in the part of the brain that we use for our most complex forms of thought, according to a new study published in Science on Thursday.

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“What we found is one gene that certainly contributes to making us human,” said Wieland Huttner, a neuroscientist at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, and one of the authors of the study.

The human brain allows us to do things that other living species cannot, such as using full-blown language and making complicated plans for the future. For decades, scientists have been comparing the anatomy of our brain with that of other mammals to understand how those sophisticated faculties evolved.

The most obvious feature of the human brain is its size — four times as large as that of chimpanzees, our closest living relatives.

Our brain also has distinctive anatomical features. The region of the cortex just behind our eyes, known as the frontal lobe, is essential for some of our most complex thoughts. According to a study from 2018, the human frontal lobe has far more neurons than the same region in chimpanzees does.

But comparing humans with living apes has a serious shortcoming: Our most recent common ancestor with chimpanzees lived roughly 7 million years ago. To fill in what happened in since then, scientists have had to resort to fossils of our more recent ancestors, known as hominins.

Inspecting hominin skulls, paleoanthropologists have found that the brains of our ancestors dramatically increased in size starting about 2 million years ago. They reached the size of living humans by about 600,000 years ago. Neanderthals, among our closest extinct hominin relatives, had brains as big as ours.

But Neanderthal brains were elongated, whereas humans have a more spherical shape. Scientists can’t say what accounts for those differences. One possibility is that various regions of our ancestors’ brains changed size.

In recent years, neuroscientists have begun investigating ancient brains with a new source of information: bits of DNA preserved inside hominin fossils. Geneticists have reconstructed entire genomes of Neanderthals as well as their eastern cousins, the Denisovans.

Scientists have zeroed in on potentially crucial differences between our genome and the genomes of Neanderthals and Denisovans. Human DNA contains about 19,000 genes. The proteins encoded by those genes are mostly identical to those of Neanderthals and Denisovans. But researchers have found 96 human-specific mutations that changed the structure of a protein.

In 2017, Anneline Pinson, a researcher in Huttner’s lab, was looking over that list of mutations and noticed one that altered a gene called TKTL1. Scientists have known that TKTL1 becomes active in the developing human cortex, especially in the frontal lobe.

“We know that the frontal lobe is important for cognitive functions,” Pinson said. “So that was a good hint that it could be an interesting candidate.”

Pinson and her colleagues did initial experiments with TKTL1 in mice and ferrets. After injecting the human version of the gene into the developing brains of the animals, they found that it caused the mice and ferrets to make more neurons.

Next, the researchers carried out experiments on human cells, using bits of fetal brain tissue obtained through the consent of women who had abortions at a Dresden hospital. Pinson used molecular scissors to snip out the TKTL1 gene from the cells in the tissue samples. Without it, the human brain tissue produced fewer so-called progenitor cells that give rise to neurons.

For their final experiment, the researchers set out to create a miniature Neanderthal-like brain. They started with a human embryonic stem cell, editing its TKTL1 gene so that it no longer had the human mutation. It instead carried the mutation found in our relatives, including Neanderthals, chimpanzees and other mammals.

They then put the stem cell in a bath of chemicals that coaxed it to turn into a clump of developing brain tissue, called a brain organoid. It generated progenitor brain cells, which then produced a miniature cortex made of layers of neurons.

The Neanderthal-like brain organoid made fewer neurons than did organoids with the human version of TKTL1. That suggests that when the TKTL1 gene mutated, our ancestors could produce extra neurons in the frontal lobe. While this change did not increase the overall size of our brain, it might have reorganized its wiring.

“This is really a tour de force,” said Laurent Nguyen, a neuroscientist at the University of Liège in Belgium who was not involved in the study.

The new finding does not mean that TKTL1, on its own, offers the secret to what makes us human. Other researchers are also looking at the list of 96 protein-changing mutations and are running organoid experiments of their own.

Other members of Huttner’s lab reported in July that two other mutations change the pace at which developing brain cells divide. Last year, a team of researchers at the University of California San Diego found that another mutation appears to change the number of connections human neurons make with each other.

Other mutations may also turn out to be important to our brains. For example, as the cortex develops, individual neurons need to migrate in order to find their proper place. Nguyen observed that some of the 96 mutations unique to humans altered genes that are likely involved in cell migration. He speculates that our mutations may make our neurons move differently than neurons in a Neanderthal’s brain.

“I don’t think it’s the end of the story,” he said. “I think more work is needed to understand what makes us human in terms of brain development.”

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