Tag Archives: natural immunity

The High Cost of Disparaging Natural Immunity to Covid

Public-health officials ruined many lives by insisting that workers with natural immunity to Covid-19 be fired if they weren’t fully vaccinated. But after two years of accruing data, the superiority of natural immunity over vaccinated immunity is clear. By firing staff with natural immunity, employers got rid of those least likely to infect others. It’s time to reinstate those employees with an apology.

For most of last year, many of us called for the Centers for Disease Control and Prevention to release its data on reinfection rates, but the agency refused. Finally last week, the CDC released data from New York and California, which demonstrated natural immunity was 2.8 times as effective in preventing hospitalization and 3.3 to 4.7 times as effective in preventing Covid infection compared with vaccination.

Yet the CDC spun the report to fit its narrative, bannering the conclusion “vaccination remains the safest strategy.” It based this conclusion on the finding that hybrid immunity—the combination of prior infection and vaccination—was associated with a slightly lower risk of testing positive for Covid. But those with hybrid immunity had a similar low rate of hospitalization (3 per 10,000) to those with natural immunity alone. In other words, vaccinating people who had already had Covid didn’t significantly reduce the risk of hospitalization.

Similarly, the National Institutes of Health repeatedly has dismissed natural immunity by arguing that its duration is unknown—then failing to conduct studies to answer the question. Because of the NIH’s inaction, my Johns Hopkins colleagues and I conducted the study. We found that among 295 unvaccinated people who previously had Covid, antibodies were present in 99% of them up to nearly two years after infection. We also found that natural immunity developed from prior variants reduced the risk of infection with the Omicron variant. Meanwhile, the effectiveness of the two-dose Moderna vaccine against infection (not severe disease) declines to 61% against Delta and 16% against Omicron at six months, according to a recent Kaiser Southern California study. In general,

Pfizer’s

Covid vaccines have been less effective than Moderna’s.

The CDC study and ours confirm what more than 100 other studies on natural immunity have found: The immune system works. The largest of these studies, from Israel, found that natural immunity was 27 times as effective as vaccinated immunity in preventing symptomatic illness.

None of this should surprise us. For years, studies have shown that infection with the other coronaviruses that cause severe illness, SARS and MERS, confers lasting immunity. In a study published in May 2020, Covid-recovered monkeys that were rechallenged with the virus didn’t get sick.

Public-health officials have a lot of explaining to do. They used the wrong starting hypothesis, ignored contrary preliminary data, and dug in as more evidence emerged that called their position into question. Many, including

Rochelle Walensky,

now the CDC’s director, signed the John Snow memorandum in October 2020, which declared that “there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection.”

Many clinicians who talk to other physicians nationwide had have long observed that we don’t see reinfected patients end up on a ventilator or die from Covid, with rare exceptions who almost always have immune disorders. Meanwhile, public-health officials recklessly destroyed the careers of everyday Americans, rallying to fire pilots, truck drivers and others in the supply-chain workforce who didn’t get vaccinated. And in the early months of the vaccine rollout, when supplies were limited, we could have saved many more lives by giving priority to those who didn’t have recorded natural immunity.

The failure to recognize the data on natural immunity is hurting U.S. hospitals, especially in rural areas. MultiCare, a hospital system in Washington state, fired 55 staff members on Oct. 18 for being out of compliance with

Gov. Jay Inslee’s

vaccine mandate—and that was in addition to an undisclosed number of staffers who quit ahead of the vaccination deadline. The loss of workers contributed to a full-blown staffing crisis.

It got so bad that the hospital summoned staff who were Covid-positive to return to work even if they were sick, according to an internal memo obtained by

Jason Rantz

of KTTH radio. The memo stated that “positive staff with mild to moderate illness” could work, so long as they wear appropriate personal protective equipment, don’t take breaks with others, and agree to stay home “if symptoms worsen.” Managers were recommended to assign Covid-positive staff to Covid-positive patients and vaccinated patients, but not immunosuppressed patients.

The Centers for Medicare and Medicaid Services took the hospital mandate national by decreeing that all medical facilities under its jurisdiction require vaccination for employees, including those with natural immunity. The Supreme Court upheld the rule on Jan. 13, the same day it issued a stay against a similar mandate from the Occupational Safety and Health Administration, which OSHA formally withdrew Tuesday.

Connecticut has suspended its vaccine mandate for state employees, and

Starbucks

is rehiring employers fired for being unvaccinated. Other states and businesses should follow their lead. Politicians and public-health officials owe an apology to Americans who lost their jobs on the false premises that only unvaccinated people could spread the virus and only vaccination could prevent its spread. Soldiers who have been dishonorably discharged should be restored their rank. Teachers, first responders, and others who have been denied their livelihood should be reinstated. Everyone is essential.

Dr. Makary is a professor at the Johns Hopkins School of Medicine and author of “The Price We Pay: What Broke American Health Care and How to Fix It.”

Wonder Land: The weaponization of ‘science’ began with climate policy and accelerated with Covid-19. Now many think it’s all misinformation. Images: AFP/Getty Images Composite: Mark Kelly

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CDC’s definition of ‘fully vaccinated’ has not kept up with the science

A year ago, the Centers for Disease Control and Prevention (CDC) defined “fully vaccinated” against SARS-CoV-2 as having received one dose of the Johnson & Johnson (J&J) vaccine or two serial doses of the Pfizer or Moderna vaccines. This definition has been used extensively across the country to establish requirements for public engagement, from work to schools to restaurants to Broadway shows, under the interpretation that those who are “fully vaccinated” are those who are safest from acquiring and spreading the virus.

Fortunately, we’ve learned a lot of science in the last year about vaccine durability, protection from new variants, as well as natural immunity. We also have much more granular ways to evaluate the likelihood that someone will put others around them at risk of COVID-19. Unfortunately, CDC’s definition has not kept up with the science, and the year-old national standard has not aged well.

We learned months ago that vaccines have limited durability, particularly in their ability to protect us from acquiring, replicating, shedding and then spreading the virus. Five months after being “fully vaccinated,” we might still have a decent T-cell repertoire to reduce the chances of getting very sick from COVID-19. However, our antibody levels have likely dropped substantially, and with them, our first line of defense against acquiring and replicating — and thus shedding and spreading — the virus. This is particularly relevant with the new omicron variant, which is so rapid and contagious that we need even higher levels of antibodies than we ever have before.

Boosters can help rekindle antibody production and immediate early protection, and CDC is wisely recommending boosters. But inexplicably, they are not incorporating boosters in the definition of “fully vaccinated.” Someone vaccinated a year ago has a much higher likelihood of putting others around them at risk of COVID-19 than someone boosted a month ago, yet CDC puts both in the same “fully vaccinated” category.

The protection afforded by boosters is on the order of 20-fold higher than without boosters, about the same magnitude as the protection afforded by vaccines in the first place. So, if it were important to distinguish between vaccinated and unvaccinated when CDC first established this definition, now it is similarly important to distinguish between boosted and unboosted. To put it more bluntly, someone whose last dose of the SARS-CoV-2 vaccine was over five months ago should no longer be considered “fully vaccinated” and is likely no longer protected enough to be around strangers indoors. Sure, they might be fine if they get COVID-19, but their chances of infecting others in that room have likely become unacceptably high.

Furthermore, the entire concept of natural immunity has been ignored by definitions that focus on “fully vaccinated” rather than “appropriately immune.” Indeed, even for those with previous COVID-19 infection, it remains essential to get vaccinated and boosted, as hybrid immunity seems to be the most powerful weapon against SARS-CoV-2. However, today it seems hard to reconcile that an unvaccinated person who recovered from moderate COVID-19 last month, and probably has very high antibody levels, is considered less “safe” than someone vaccinated a year ago, who probably has very low antibody levels.

Several things have changed over the last few months to make addressing the role of natural immunity an imperative. First, we now have a much better sense of how to measure and interpret antibody levels. Second, vaccine immunity is waning, so the chosen standard to which natural immunity has been held is now widely heterogeneous. Third, thanks to the omicron variant, there are now tens of millions of Americans who had very recent infections and, thus, likely high immunity right now.

CDC needs to expand its definition for two groups contending with natural immunity. First, there are many Americans who were hesitant about vaccines, got COVID-19, and remain hesitant, holding their ground that their natural immunity is at least equivalent to vaccination. Demonstrating a certain level of antibodies could be a way for these folks to support this stipulation. Antibodies are now well-established to correlate with neutralization and clinical protection. While not perfect, and a bit challenging to identify acceptable antibody tests and protective levels, it would certainly be better than the current CDC definition that ignores natural immunity altogether. CDC could also use an estimate of natural infection durability, similar to that used for vaccine durability, possibly requiring antibody demonstrations only from those outside this durability window. Such a paradigm could also be used for those who were vaccinated but are booster-hesitant, or those who wish to wait longer before seeking a booster: demonstrate that your antibodies are high enough, and you buy yourself more time. 

Second, there are many people — especially since omicron surged — who were initially vaccinated, soon to be eligible for boosters, but got COVID-19 before getting boosted. CDC needs to clarify guidance for when to get boosted and update the definition of “fully vaccinated” to account for this natural booster. As above, this could be a combination of an estimated durability window and antibody demonstration for those outside the window.

Like it or not, the CDC definition of “fully vaccinated” has become the de facto rule of public engagement — an indication of how safe someone is to be around strangers, adopted by many institutions across the country — and not a biological indication of how sick someone will become if infected. Sadly, right now, this definition is embarrassingly outdated, ignoring new science about vaccine durability, new variants and natural immunity. This is causing major problems, both medical and political, as well as intense confusion. It’s been a year. It’s time for an update.

Dorry Segev, MD, Ph.D., is a professor of surgery at Johns Hopkins University School of Medicine and Professor of Epidemiology at Johns Hopkins Bloomberg School of Public Health. Segev has been leading an observational study of COVID-19 vaccine responses in immunosuppressed people since December 2020 and is the principal Investigator of the NIH/NIAID-funded interventional trial “COVID-19 Protection After Transplantation (CPAT).” Follow him on Twitter: @dorry_segev



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Coronavirus Updates: Restrictions to be lifted on fully-vaccinated, non-American travelers Monday

NEW YORK (WABC) — The U.S. is lifting restrictions on foreign travelers who are fully vaccinated against COVID, starting Monday.

The Biden administration is expecting long lines and delays at airports with travelers possibly pouring into the states.

When the announcement was made, online searches for international flights jumped 338%.

Delta Airlines saw bookings shoot up by 450%, and United Airlines says it will be bringing 30,000 travelers into the U.S. on Monday alone.

Here are more of today’s COVID-19 headlines:

Novavax says its vaccine could win over skeptics

The biotechnology company Novavax plans to submit complete data to the US Food and Drug Administration soon for possible emergency use authorization of its coronavirus vaccine, CEO Stanley Erck told CNN in a phone interview Friday. Novavax’s vaccine, called NVX-CoV2373, is made using somewhat more conventional methods than the vaccines already authorized for use in the US.

US cancels vaccine maker’s multimillion dollar deal
The federal government has canceled a multimillion dollar deal with Emergent BioSolutions, a Maryland-based vaccine manufacturer with facilities in Baltimore that were found to have produced millions of contaminated Johnson & Johnson vaccine doses this spring, the Washington Post reported. Emergent disclosed the development Thursday in a conference call discussing its latest financial results, the Post reported. Emergent said it will forgo about $180 million due to the contract’s termination, according to the Post. Emergent BioSolutions played a role in the Trump administration’s effort to speed up vaccine development and distribution. But after winning a contract from the previous administration, Emergent quickly ran into production problems. In March, ingredients intended for use in producing the Oxford-AstraZeneca vaccine shots contaminated 15 million doses of the Johnson & Johnson vaccine. The problems with the vaccines caused a monthslong delay in production. After that, the Biden administration put Johnson & Johnson in direct control of vaccine production there.

15 unions reach COVID vaccine mandate deal with NYC, talks continue with outliers
New York City employees who don’t want to get vaccinated have until Friday to file for a religious or medical exemption if they have any hope of staying on the payroll, this as the city announces more deals with unions representing municipal workers. Mayor Bill de Blasio said Friday that 15 unions, including city’s largest, DC 37, have signed onto the deal. The unions represent more than 100,000 city workers covered by this most recent mandate that took effect last week, but the police and fire unions are not included and are still trying to hash out their own deals. Around 92% of city workers under the mandate are vaccinated, including 90% of EMS, 79% of firefighters, 85% of sanitation workers, and 85% of NYPD employees.

COVID vaccine refusal 10th highest reason for job cuts in 2021, report says
While experts say we’re still in the so-called “Great Resignation,” a recent Jobs Cut Report uncovered vaccine refusal as the 10th highest reason for job cuts this year. Numbers released by Chicago-based outplacement and business and executive coaching firm Challenger, Gray & Christmas, Inc. came on on the same day President Biden announced new federal guidance and deadline for tens of millions of workers to get vaccinated.
“Roughly 5,000 people that lost their jobs in the last month due to COVID vaccine refusal made up actually 22% of the total number of people that we tracked being let go across the country,” the firm’s Senior VP Andy Challenger told our sister station KGO-TV.

Pfizer’s COVID-19 pill reduces risk of being hospitalized or dying by 89%, company says

A course of pills developed by Pfizer can slash the risk of being hospitalized or dying from COVID-19 by 89% if taken within three days of developing symptoms, according to results released Friday by the pharmaceutical company. In a study of more than 1,200 COVID-19 patients with a higher risk of developing serious illness, people who took Pfizer’s pills were far less likely to end up in the hospital compared to people who got placebo pills. None of the people who got the real pills died, but 10 people who got placebo pills died, according to results summarized in a Pfizer press release.
SantaCon returns
After taking a year off due to the pandemic, SantaCon is returning to New York City. The event requires a $13 donation for all-inclusive Santa Badge access to the official SantaCon venues. The location of a Yuletide kickoff party won’t be disclosed until closer to the December 11 SantaCon date.

Turkey Day troubles? Smaller birds, popular Thanksgiving sides could be harder to find in 2021
Consumers may have to trim their list of trimmings for their highly anticipated Thanksgiving meal this year. Top turkey seller Butterball said it doesn’t expect an overall gobbler shortage, but that those in search of a smaller size bird could have a hard time.
“Typically a 10- to 12-pound (turkey) up to 14 pounds is going to be more difficult,” Butterball CEO Jay Jandrain told “Good Morning America” on Friday. “Anything over 16 pounds, they’ll certainly be more readily available.”

Q&A: What to know about COVID-19 vaccines for kids aged 5-11
Vaccinations finally are available to U.S. children as young as 5, to the relief of some parents even as others have questions or fears. Late Tuesday, the Centers for Disease Control and Prevention gave the final OK for youngsters age 5 to 11 to get kid-size doses of the vaccine made by Pfizer and its partner BioNTech. Pediatricians and other doctors’ groups praised the move and are gearing up to help families decide whether to vaccinate their children. The shots could be available as soon as Wednesday and will be offered at pediatricians offices, clinics and pharmacies. Like COVID-19 vaccines for adults, they are free. Here’s everything you need to know.

Will the supply chain issues impact holiday shopping? Here’s what the experts say

With the holiday shopping suddenly upon us, it appears that getting that perfect gift or preparing that perfect meal will be far more challenging than in years past due to supply chain issues. Shoppers are noticing that it’s difficult to find a variety of items, and virtually everything from food to Christmas trees are more expensive. The price increase is being caused by gridlock at major seaports and a truck driver shortage across the country. Analysts say the forecast for the holiday season is not looking better.

MORE CORONAVIRUS COVID-19 COVERAGE

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Dr. Robert Malone on Ivermectin, Escape Mutants, and the Faulty Logic of Vaccine Mandates

PART 2: Dr. Robert Malone on Ivermectin, Escape Mutants, and the Faulty Logic of Vaccine Mandates

In part one of this American Thought Leaders episode, mRNA vaccine inventor Dr. Robert Malone explained the latest research on COVID-19 vaccines, booster shots, and natural immunity.

Now in part two, we take a closer look at repurposed drugs like ivermectin and how a universal vaccination policy could actually backfire—and bring about the emergence of vaccine-resistant escape mutants.

At their core, vaccine mandates are not just unethical and divisive, but also “impractical and unnecessary,” says Dr. Malone.

You can watch the first part of this episode here.

Below is a list of references mentioned or related to the discussion in this episode: 

“Ivermectin for preventing and treating COVID-19” — The Cochrane Database of Systematic Reviews

“Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019” — Chest Journal

“Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19” — American Journal of Therapeutics

“Effects of Ivermectin in Patients With COVID-19: A Multicenter, Double-Blind, Randomized, Controlled Clinical Trial” — Clinical Therapeutics

“Dexamethasone in Hospitalized Patients with Covid-19” — The New England Journal of Medicine

“ACTIV-6: COVID-19 Study of Repurposed Medications” — NIH

“Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals” — Cell Reports

“Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization” — Nature

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines (Note: This is a preprint)

“Mutation rate of COVID-19 virus is at least 50 percent higher than previously thought” — Phys.org

“Infection and Vaccine-Induced Neutralizing-Antibody Responses to the SARS-CoV-2 B.1.617 Variants” — The New England Journal of Medicine

“Why is the ongoing mass vaccination experiment driving a rapid evolutionary response of SARS-CoV-2?” — Trial Site News

“The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape” (Note: This is a preprint)

“The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines” (Note: This is a preprint)

“Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens” — PLOS Biology

“Vaccinated and unvaccinated individuals have similar viral loads in communities with a high prevalence of the SARS-CoV-2 delta variant” (Note: This is a preprint).

“Fauci: Amount of virus in breakthrough delta cases ‘almost identical’ to unvaccinated” — The Hill

CDC: “Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021”

“Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California” (Note: This is a preprint)

“New delta variant studies show the pandemic is far from over” — ScienceNews

“Read: Internal CDC document on breakthrough infections” — The Washington Post

“New UCSF study: Vaccine-resistant viruses are driving ‘breakthrough’ COVID infections” — The Mercury News

“Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections” (Note: This is a preprint)

“Having SARS-CoV-2 once confers much greater immunity than a vaccine—but vaccination remains vital” — Science

“Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals” (Note: This is a preprint)

“SARS-CoV-2 variants of concern and variants under investigation in England” — Public Health England

“Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting” — The New England Journal of Medicine

“Real-World Study Captures Risk of Myocarditis With Pfizer Vax” — MedPage Today

CDC: “Effectiveness of COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Frontline Workers Before and During B.1.617.2 (Delta) Variant Predominance — Eight U.S. Locations, December 2020—August 2021”

“CDC: Covid-19 Vaccine Effectiveness Fell From 91% To 66% With Delta Variant“ — Forbes

“SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans” — Nature

“Causes and consequences of purifying selection on SARS-CoV-2” — Genome Biology and Evolution

“The reproductive number of the Delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus” — Journal of Travel Medicine

“Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals” (Note: This is a preprint)

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