Tag Archives: Muscle

Gene Therapy for Kids’ Deadly Muscle Disease Fails to Reach Trial Goal – Yahoo Finance

  1. Gene Therapy for Kids’ Deadly Muscle Disease Fails to Reach Trial Goal Yahoo Finance
  2. Sarepta’s Duchenne gene therapy fails to meet primary endpoint in pivotal trial STAT
  3. SRPT Stock Crashes To Six-Year Low As Its Gene Therapy Flops In Its Biggest Test Investor’s Business Daily
  4. Sarepta Therapeutics Announces Topline Results from EMBARK, a Global Pivotal Study of ELEVIDYS Gene Therapy for Duchenne Muscular Dystrophy Business Wire
  5. Sarepta’s muscular dystrophy therapy fails to meet main goal in late-stage trial CNBC
  6. View Full Coverage on Google News

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3D Muscle Reconstruction Reveals 3.2 Million-Year-Old “Lucy” Could Stand As Erect as Modern Humans – SciTechDaily

  1. 3D Muscle Reconstruction Reveals 3.2 Million-Year-Old “Lucy” Could Stand As Erect as Modern Humans SciTechDaily
  2. How a 3.2-million-year-old human relative named Lucy walked CNN
  3. 3.2 million-year-old human ancestor ‘Lucy’ had massive leg muscles to stand up straight and climb trees Livescience.com
  4. 3D muscle reconstruction shows 3.2 million-year-old “Lucy” walked upright Ars Technica
  5. 3D muscle reconstruction reveals 3.2 million-year-old ancestor walked upright Interesting Engineering
  6. View Full Coverage on Google News

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Michael B. Jordan admits muscle gain for ‘Creed’ has been harder as he’s gotten older – Yahoo Entertainment

  1. Michael B. Jordan admits muscle gain for ‘Creed’ has been harder as he’s gotten older Yahoo Entertainment
  2. Michael B. Jordan Diet: Workout Plan ‘Creed,’ ‘Black Panther’ Cheat Day STYLECASTER
  3. Michael B. Jordan and Jonathan Majors on ‘Creed III’ The New York Times
  4. How Jonathan Majors prepared to fight Michael B. Jordan in ‘Creed III’ Entertainment Weekly News
  5. Director Michael B. Jordan turned to Jon Favreau, Denzel Washington, and Bradley Cooper as sounding boards for Creed III Bollywood Hungama
  6. View Full Coverage on Google News

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College basketball scores, winners and losers: Big 12 flexes muscle vs. SEC to win final challenge

Chaos reigned supreme across the college basketball landscape as seven ranked teams fell to unranked teams in a shakeup Saturday of stupendous proportions. 

No. 2 Alabama was the (unfortunate) poster child of such chaos as the Crimson Tide — No. 3 in scoring margin among power conference teams headed into the weekend — got flattened by Oklahoma by 24 points on the road in the SEC/Big 12 Challenge. 

But Alabama wasn’t the only team to find itself on the losing side of a blowout in the SEC/Big 12 Challenge as No. 12 Iowa State also slipped up on the road, falling 78-61 to Missouri. 

Here’s how the final SEC/Big Challenge played out:

SEC/Big 12 Challenge

Big 12 wins 7-3

West Virginia 80, No. 15 Auburn 77 Recap
Oklahoma 93, No. 2 Alabama 69 Recap
Texas Tech 76, LSU 68 Recap
Missouri 78, No. 12 Iowa State 61 Recap
Mississippi State 81, No. 11 TCU 74 Recap
No. 17 Baylor 67, Arkansas 64 Recap
No. 4 Tennessee 82, No. 10 Texas 71 Recap
No. 5 Kansas State 64, Florida 50 Recap
No. 9 Kansas 77, Kentucky 68 Takeaways
Oklahoma State 82, Ole Miss 60 Recap

Elsewhere, Big East-leading and 13th-ranked Xavier also got pounded by unranked Creighton.

Oh, [Billy Mays voice] but wait, there’s more! 

Monmouth — which had the fewest wins of all Div. I teams entering Saturday — defeated North Carolina A&T by 15 points as a double-digit underdog. Meanwhile, No. 18 Charleston — which had the most wins of all Division I teams entering Saturday — lost in a stunner to Hofstra, ending what was the longest winning streak in college basketball at 20 games.

That’s but a sampling of the madness that arose in college basketball from a wild day. Here is a look at the others with some of the day’s biggest winners and losers.

Winner: Tennessee gets hot

No. 4 Tennessee’s defensive reputation is well-known — the Volunteers rank No. 1 nationally in adjusted defensive efficiency at kenpom.com — but their offense has been a source of concern at times this season. In an 82-71 win over No. 10 Texas, offense carried the day. The Vols shot 55.6% from the floor led by a career-high 27 points from Olivier Nkamhoua and 22 from Zakai Ziegler. The win marked a bit of revenge for Tennessee, which dropped a 52-51 thriller at Texas last season as coach Rick Barnes returned to the school where he spent 17 seasons. The Longhorns have struggled to find consistency since Barnes’ tenure ended while the Volunteers appear destined to be a No. 5 seed or better in the NCAA Tournament for a fifth time in Barnes’ eight season with the program.

Winner: Kansas dominates offensive glass

No. 9 Kansas beat Kentucky at its own game in a 77-68 win inside Rupp Arena as the Jayhawks used an 11-0 advantage in second-chance points to snap a three-game losing streak. Kentucky entered the game ranked No. 5 nationally in offensive rebounds per game at 14 while Kansas ranked No. 145 in the same category at 10.7 per game. With the Jayhawks relying on an undersized center in KJ Adams Jr. and the Wildcats boasting one of the game’s top rebounder in Tshiebwe, it seemed UK would have an obvious advantage on the glass. Instead, it was Kansas that dominated in that regard.

Loser: Kentucky goes cold

The Wildcats entered their loss to Kansas on a four-game winning streak that had changed the trajectory of their once-directionless season. However, a developing problem bubbled to the surface and haunted the Wildcats on Saturday as they hit just 2 of 13 attempts from 3-point range. After shooting 35.4% from beyond the arc in their first 16 games, UK is shooting just 24.1% from 3-point range over its last five contests. Unless Antonio Reeves and CJ Fredrick find their perimeter stroke again, the Wildcats risk losing the progress they made over the past two weeks.

Winner: Arizona finds top gear

No. 6 Arizona has looked like an elite, well-oiled machine at times this season and also had moments when it has looked disjointed and vulnerable. The Wildcats put the better version of themselves on display in a 95-72 thrashing of Washington. Azuolas Tubelis scored 25 points and grabbed 10 rebounds, and Arizona outscored the Huskies 57-36 in the second half for a fourth straight win. Arizona turned the ball over just twice in the second half, made 7 of 16 attempts from 3-point range, hit 10 of 11 free throws and won the battle of second-chance points 10-0. It was a near-perfect half and it was a reminder of how scary the Wildcats can be when at their best.

Winner: K-State’s Johnson beats old team

The prospect of Keynotae Johnson playing college basketball again seemed bleak in the months after he collapsed on the court while playing for Florida early in the 2020-21 season. The idea that he would one day suit up against the Gators seemed even more improbable. But that’s what happened Saturday as Johnson and No. 5 Kansas State beat Florida 64-50. Johnson finished with 13 points and 11 rebounds as the Wildcats jumped out to a 37-16 halftime lead and cruised to a stress-free win. 

Loser: Sky is falling on Ohio State

The sky fell on Ohio State during its 86-70 loss at Indiana. Literally. A piece of metal fell from somewhere above the court at Assembly Hall and narrowly missed striking Ohio State freshman star Brice Sensabaugh at halftime. OSU coach Chris Holtman told reporters that he inquired about a delay or postponement of the game. But to no avail. The Buckeyes dropped to 11-10 (3-7 Big Ten) with the loss, which was their seventh of the past eight games. At this rate, Ohio State should consider asking for a postponement of the rest of the season. 

Winner: Clemson survives again

Clemson trailed 81-79 at Florida State when Chase Hunter took an inbounds pass on the opposite end of the floor with 8.5 seconds left and took off with a full head of steam. Instead of looking for a go-ahead 3-pointer, he took FSU defender Matthew Cleveland to the basket off the dribble and banked in a contested lay-up. 

As the ball went through the basket, the whistle sounded. It was a foul call on Cleveland, which sent Hunter to the line with a chance to put the Tigers ahead. He drilled the free throw, and Clemson held on for yet another dramatic victory. Last Saturday, it was Hunter Tyson who was the hero in a 51-50 win over Virginia Tech. 

This time it was Hunter as the Tigers improved to 18-4 (10-1 ACC) and maintained their edge in the ACC standings. Despite its gaudy record, Clemson entered as just a projected No. 10 seed in Jerry Palm’s Bracketology. A loss to the struggling Seminoles would have been a bad look. But thanks to their penchant for late-game heroics, the Tigers stayed in the win column for their 10th time in the past 11 games.

Loser: Miami goes cold in loss to Pitt

No. 20 Miami took a 68-60 on Pittsburgh lead with 2:26 remaining until disaster struck. The Hurricanes choked in epic fashion as the Panthers closed on an 11-0 run for an improbable and much-needed 71-68 win. Pitt entered the day as one of the “Last 4 In” the projected NCAA Tournament field according to CBS Sports Bracketology Expert Jerry Palm. Pitt won the battle of second-chance points by a whopping 17-2 margin and has now won four of its past five games, improving to 15-7 (8-3) in what has been a redemption campaign for the program under embattled fifth-year coach Jeff Capel.

Winner: West Virgina gets a bubble win

West Virginia entered the day as one of the “First 4 Out” of Jerry Palm’s Bracketology and emerged with a critical Quad 1 victory as the Mountaineers outlasted No. 15 Auburn 80-77. Erik Stevenson piled up 31 points to lead the Mountaineers as he drilled 7 of 10 attempts from 3-point range in critical victory.

Winner: Baylor rounding into form

No. 17 Baylor blew an 11-point lead and then came back from an eight-point deficit in a 67-64 win over Arkansas that featured some wild momentum swings. Now, all of the sudden, the Bears are winners of six straight and sitting pretty at 16-5 overall. Keynote George keyed Baylor with 24 points and LJ Cryer added 20 as the Bears’ backcourt continued to look like one of the nation’s best. This team faded from the national radar following a three-game losing streak to begin Big 12 play but appears to be rounding into form with the potential return of big man Jonathan Tchamwa Tchatchoua looming as a possibility at some point in the days ahead.

Loser: VCU takes bad loss

VCU entered the day as a projected No. 12 seed in Jerry Palm’s Bracketology but suffered a Quad 4 home loss by falling 61-58 against a St. Bonaventure team that entered the day ranked No. 184 in the NET. The Rams (16-6, 7-2 A-10) entered on a six-game winning streak that featured five double-digit victories but made just 2 of 16 attempts from 3-point range and only 10 of 18 free throws. Defense was also an issue in the second half as St. Bonaventure shot 56% from the floor and drilled 5 of 6 long-range attempts after the break.

Winner: Creighton turning corner

Following a meltdown of shocking proportions at the end of November and the start of December, preseason top-10 Creighton is slowly but surely rounding into form with the look of a top-10 team in the sport. The Bluejays pounded Big East-leading and No. 13-ranked Xavier 84-67 on Saturday for their fourth consecutive win to move to within 1.5 games of the conference’s top spot in the regular-season race. The hole they put themselves in early with a 3-3 start in conference play may be too difficult to overcome for a league title, but it’s clear this talented roster is finding its confidence and seems to be rolling into the stretch part of the season full steam ahead.

Entering an 82-67 win at Portland, Gonzaga’s Julian Strawther owned a career-high of 23 points. Strawther matched that total in the second half alone as the 6-foot-7 wing exploded for 40 total points. He drilled 8 of 12 shots from 3-point range as the No. 14 Zags improved to 18-4 (7-1 WCC).

Loser: BYU suffers another crushing loss

Speaking of Strawther, he was the first player to rip BYU’s heart out with a game-winning shot back on Jan. 12 when his deep 3-pointer to lift Gonzaga to a 75-74 win over the Cougars. Saint Mary’s guard Aidan Mahaney became the second to do it on Saturday night as he drilled a jumper with 0.3 seconds left to lift the No. 22 Gaels to a 57-56 win. Saint Mary’s improved to 18-4 (7-0) with the win as Mahaney continued an illustrious freshman campaign.

Loser: Charleston’s winning streak ends

The longest active winning streak in college basketball came to an unceremonious end on Saturday as No. 18 Charleston fell at home as a 9-point favorite to Hofstra 85-81. The loss, which moved Hofstra to within one game of the CAA’s regular-season No. 1 spot, was Charleston’s first in more than two months after falling to North Carolina in its second game of the season, only to reel off 20-straight in the win column since. 

Winner: FAU takes Charleston’s place

What was Charleston’s loss (literally) was FAU’s win (also literally!) as Florida Atlantic with a 70-63 win over Western Kentucky extended its winning streak to 20 games and took Charleston’s spot as the team with the longest winning streak in the sport. No. 21 FAU improved to 21-1 on the season and remained perfect in Conference USA play with a perfect 11-0 league record.

Loser: Georgia Tech struggling under Pastner

Year 7 for Josh Pastner at Georgia Tech went from bad to humiliating in an 86-43 home loss to Duke as the Yellow Jackets suffered their seventh straight loss and fell to 8-13 (1-10 ACC). Georgia Tech shot just 30.9% from the floor and got manhandled 44-12 in paint points. Of the Yellow Jackets’ 10 league losses, nine have come by double digits, and it’s a near certainty that the season will conclude with Pastner still lacking an NCAA Tournament victory at the school. The 2021 team that won the ACC Tournament — though it played only two games in the event due to COVID-19 issues with other teams — bought Pastner some goodwill. But after a 12-20 campaign in 2021-22 and this horrendous clunker of a season, the reasons for Georgia Tech to continue with Partner are running thin.

Winner: NC State finally gets another Quad 1 win

NC State made just 8 of 17 free throws and somehow managed to pick up a Quad 1 road victory anyway as the Wolfpack outlasted Wake Forest 79-77. D.J. Burns led NC State with 31 points on a whopping 14 of 26 shooting, and the big man would have scored even more if he’d made more than 3 of 8 attempts from the charity stripe. Nevertheless, the win was huge for the Wolfpack as it marked just their second Quad 1 victory. NC State entered the day as a projected No. 7 seed in Jerry Palm’s Bracketology and needed a little meat on the resume to give itself margin for error. Saturday’s win provided it.

Winner: Bethune-Cookman wins it to cap chaotic week

With Bethune-Cookman’s football program in the news the last week for all the wrong reasons, the basketball team took it upon itself to provide a positive highlight. And boy did it deliver exactly that to cap what must have been an exhausting week for Wildcats basketball coach Reggie Theus, who is also the B-CU athletic director and in charge of dealing with the issues in the football program.

The Wildcats won 64-62 on a last-second shot over Alabama State at home and did so in fashion while covering the 1.5-point spread to boot. 

Loser: UCF’s fall continues

After a 107-104 win over Memphis on Jan. 11, UCF stood at 13-4 (4-1 AAC) and ranked No. 35 in the NET. The Golden Knights were on the right side of the NCAA Tournament bubble and appeared to be building momentum ahead of next season’s transition to a far more difficult life in the Big 12. But over the last two weeks, reality has come crashing down on UCF, which dropped its fourth straight with a 77-70 overtime home loss against Temple on Saturday. The Owls entered the day at No. 125 in the NET but have suddenly won four straight, including a road win over Houston last Sunday. But this one will be hard to swallow for UCF, which led by 10 in the first half. The Golden Knights’ football program is on firm footing and should be competitive in the Big 12, but the last couple weeks have been a reminder that the school could be in for a rude awakening on the hoops side.

Loser: TCU’s injury luck

With big man Eddie Lampkin Jr. out, TCU’s injury luck went from bad to worse on the road vs. Mississippi State as star guard Mike Miles Jr. hyperextended his knee and reserve guard Shahada Wells briefly left the game with an injury before returning. Miles did not return to the game and Lampkin is sidelined indefinitely, and adding insult to the injuries, the No. 11 Horned Frogs came out on the losing end of an overtime effort, falling 81-74 on the road.

Winner: Fordham matches best win total in 17 years

Fordham basketball appeared to have finally found a coach worth keeping when former Villanova assistant Kyle Neptune led the Rams to a 16-16 record last season, marking the program’s first season with a .500 record since 2015-16. Then, Neptune left to replace Jay Wright at Villanova. But after choosing to elevate associate head coach Keith Urgo to head coach, Fordham has multiplied the momentum that Neptune sparked. The Rams improved to 17-4 (5-3 A-10) with an 85-70 win over George Washington on Saturday to match the program’s best win total of the past 17 seasons. With two more wins, Fordham will have its most victories since the 1991-92 season. The next step for Fordham may be hanging on to Urgo, who has assistant coaching stops at Villanova and Penn State under his belt and is a candidate for Atlantic 10 Coach of the Year.

Loser: Alabama gets pummeled by OU

For most of the season Alabama has been ganging up on inferior opponents and not just winning, but winning big; its scoring margin entering Saturday was third-highest among all major conference teams. But against unranked OU on the road, it was Alabama on the receiving end of a butt-whoopin’ as the Sooners won 93-69, handing them their largest loss by margin of the Nate Oats era. (Its last loss by 20 or more came in 2018-19 when it fell to rival Auburn by 21 points.)

“I thought the guys kept on bouncing back. I’ve seen some crazy runs by Alabama [this season],” said OU coach Porter Moser. “We had some good offensive possessions, good defensive possessions. That was the key to stopping their runs, and they didn’t really have any against us.”

Winner: Marquette ties for Big East lead

The Big East coaches picked Marquette to finish ninth in the conference before the season. After an 89-69 win at DePaul and Xavier’s loss at Creighton, the No. 16 Golden Eagles are now tied for first. David Joplin exploded for a career-high 28 points on 8 of 11 shooting from 3-point range and Tyler Kolek added 24 as Marquette racked up 56 points and 11 made 3-pointers in the second half. The Golden Eagles have won eight of their last nine and now sit at No. 1 nationally in offensive efficiency, per Kenpom.com. In just his second season as coach, Shaka Smart has revitalized the Marquette program and his own reputation as a coach.

Loser: Wisconsin’s season slipping away 

After an 11-2 start to the season for Wisconsin with wins over USC, Marquette and Iowa and a close OT loss to reigning national champion Kansas, the Badgers looked like a formidable force in the Big Ten and beyond. Fast forward three weeks and some change and the momentum they carried into 2023 has all but totally dissipated with its 61-51 loss to Illinois, its sixth loss in seven games. Wisconsin has been a consistent winner under Greg Gard, Bo Ryan’s successor, but it matches the worst seven-game stretch under Gard since he took over the program in 2015.

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5 Bad Fitness Habits That Cause You To Lose Muscle Mass

The foundation of any successful fitness regimen is built upon healthy habits. Whether your goal is to run your first marathon, set a deadlift personal record, or commit to a daily walking routine, the key is sticking to regular habits that nudge you along the path to a healthier, fitter you. However, when it comes to reaching your health and fitness goals, knowing what not to do is often equally as important as knowing the right things to do. Building and maintaining muscle mass is no exception to this universal rule. To help you develop and hold on to your lean muscle, we’re sharing five bad fitness habits that cause you to lose muscle mass so you can avoid them at all costs.

You can spend countless hours in the gym and train with Tazmanian devil-like intensity, but if you have lousy fitness habits, you’re shooting yourself in the proverbial foot and are unlikely to reach your fitness goals. Fortunately, by making minor tweaks to your nutrition, workout routine, and daily behaviors, you’ll avoid the pitfalls of bad habits and drastically improve your ability to grow muscle. Certified personal trainer Kate Meier, CPT of Gym Garage Reviews shares the lowdown on which bad fitness habits you should avoid like the plague. Keep reading to find out what they are, then check out The 5 Best Diet & Exercise Tips To Regain Muscle Mass.

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A surefire way to lose muscle mass is not consuming enough energy (calories). Food is fuel for your muscles, and not eating enough calories means your body will run on an empty tank.

“Significantly cutting calories combined with intensive cardio will lead to muscle loss over time,” says Meier. “Speak with a nutritionist or use an online calorie calculator to help determine how many calories your body needs to support everyday functions and your training regimen.”

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“Training consistently is a key aspect of building muscle, but overtraining can have the exact opposite effect,” cautions Meier. Unless you’re an endurance athlete who runs marathons or competes in triathlons, working out too much can lead to overtraining syndrome (OTS), a condition that occurs when you don’t allow for proper recovery after consistent, vigorous training sessions, according to the Hospital for Special Surgery (HSS). Additionally, reduced muscle glycogen levels and muscle weakness are associated with overtraining, research shows. Common symptoms of OTS include extended fatigue, poor sleep quality, low energy, persistent muscle soreness, and mood swings, according to the HSS.

RELATED: Over 50? Here Are 6 Exercise Mistakes You’re Too Old To Make

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Sleep is likely the most powerful (yet most underrated) aspect of any health or fitness goal. Practicing good sleep hygiene and making high-quality, restorative sleep a top priority will help you maintain and grow muscle. Research shows that not getting good quality sleep, or not sleeping enough, can heighten your risk of losing muscle mass.

“Your muscles repair and grow while you sleep, and sleep regulates virtually all of your bodily functions,” says Meier. “Aim to get eight solid hours of shuteye each night. This will help prevent long-term fatigue and help with muscle growth if you work out consistently.”

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Your body consists of roughly 20% protein; it’s found in all of your cells. Therefore, getting enough protein is critical for not only good health but also for building and retaining muscle mass.

“Regardless of your nutrition strategy, ensure you’re getting enough protein in your diet,” says Meier. “Muscle is fueled by protein, so proper recovery and muscle growth depends on it.”

While the international recommended dietary allowance (RDA) for the amount of protein you should consume is 0.8 grams per kilogram of your body weight, you’ll need to consume more if your goal is to optimize muscle growth and recover from workouts faster. The American College of Sports Medicine (ACSM) recommends consuming between 1.2 and 2.0 grams of protein per kilogram of body weight daily for the best results. Just make sure you’re strength training and getting your protein from whole food sources and high-quality protein powders.

RELATED: The Best Fitness Habits That Increase Your Muscular Endurance After 50

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While regular cardio exercise is fantastic for overall health, going overboard can cause muscle loss. The Physical Activity Guidelines for Americans recommend that healthy adults get a minimum of 150 minutes of moderately intense aerobic exercise per week. However, consistently going above and beyond this threshold—combined with not eating enough calories or doing strength training—is a bad habit for anyone wanting to maintain or regain muscle mass.

“Making sure your body is properly fueled ahead of cardio workouts is crucial, because as much as it helps you burn more calories and fat, it will also burn muscle once other energy sources are depleted,” says Meier. “The bottom line is you should find a good balance between cardio and strength training if your goal is muscle growth.”

Adam Meyer

Adam is a health writer, certified holistic nutritionist, and 100% plant-based athlete. Read more about Adam

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How Exercise Might Mitigate Age-Related Decline in Skeletal Muscle Structure and Function

Summary: Study reveals exercise is associated with myonuclear remodeling and may contribute to the protective effects of exercise on muscle function throughout the lifespan.

Source: King’s College London

Research has found that exercise is associated with changes to the nucleus in muscle fibres and may contribute to the protective effects of exercise on muscle function throughout the lifespan.

The paper’s authors, from the School of Cardiovascular and Metabolic Medicine & Sciences and the Centre for Human & Applied Physiological Sciences, isolated single muscle fibres from young and older exercise trained individuals.

In particular, they used tissue from young marathon runners and elderly master cyclists – with the latter capable of cycling 100km in under 6.5 hours (with an average age of 76).

Strikingly, they found that myonuclei – commonly referred to as the ‘control centre’ of muscle fibres – were more spherical, less deformable, and contained more of a protein called lamin A than untrained individuals. Parallel studies in mice confirmed changes in lamin A, and showed that myonuclei were stiffer as a result of exercise. 

Writing in the Journal of Physiology, they concluded that exercise is associated with myonuclear remodelling, which is preserved in older people, and may contribute to the protective effects of exercise on muscle function throughout the lifespan.

Age-related decline in skeletal muscle function, such as muscle strength and endurance, can result in reduced quality of life. Whilst it is appreciated that exercise can mitigate the decline in muscle function, the precise mechanisms that control this process are not fully understood.

Characterizing the subcellular changes associated with exercise may therefore improve our understanding of how exercise can extend functionality in old age.

Apart from housing the genome of the cell, the nucleus is capable of sensing and responding to physical forces, which can alter nucleus shape and activate cell communication pathways.

Defects in proteins that control the mechanics of nuclei, such as lamin A, are hallmarks of some diseases including heart disease, muscular dystrophy and premature aging disorders.

In these conditions, nuclei are misshapen and more deformable, with aberrant cell communication. However, whether these particular properties are affected in aging and exercise was previously unknown.

The researchers speculated that nuclei in muscle cells, called myonuclei, would show similar abnormalities to laminopathies in aging individuals. 

Dr Matthew Stroud, Principle Investigator of the Stroud Lab, said: “Whilst we know that exercise is able to overcome various detrimental aspects of the aging process, our molecular understanding of this is incomplete. Here we used both humans and mice to show that changes to nucleus shape and structure in muscle are strongly associated with exercise.”

Age-related decline in skeletal muscle function, such as muscle strength and endurance, can result in reduced quality of life. Image is in the public domain

As gatekeepers of the genome, nuclei govern cell fate and function, and the nuclear alterations we observed may promote muscle adaptation to exercise. This may help to mitigate muscle dysfunction with age.”

Human lifespan has increased substantially over the past half-century and this trend is projected to continue. One concern, however, is that this has not been accompanied by an equivalent extension of healthspan – the part of a person’s life when they are generally in good health – in old age.

Instead of this, morbidity has been extended, and independence and quality of life has reduced. The authors hope that unraveling the beneficial effects of exercise may guide treatments to improve the healthspan of our ever-expanding aging population.

About this exercise, aging, and muscle function research news

Author: Press Office
Source: King’s College London
Contact: Press Office – King’s College London
Image: The image is in the public domain

See also

Original Research: Open access.
“Myonuclear alterations associated with exercise are independent of age in humans” by Matthew Stroud et al. Journal of Physiology


Abstract

Myonuclear alterations associated with exercise are independent of age in humans

Age-related decline in skeletal muscle structure and function can be mitigated by regular exercise. However, the precise mechanisms that govern this are not fully understood. The nucleus plays an active role in translating forces into biochemical signals (mechanotransduction), with nuclear lamina protein

Lamin A regulating nuclear shape, nuclear mechanics, and ultimately gene expression. Defective Lamin A expression causes muscle pathologies and premature ageing syndromes, but the roles of nuclear structure and function in physiological ageing and in exercise adaptations remain obscure.

Here, we isolated single muscle fibres and carried out detailed morphological and functional analyses on myonuclei from young and older exercise-trained individuals.

Strikingly, myonuclei from trained individuals were more spherical, less deformable, and contained a thicker nuclear lamina than untrained individuals. Complementary to this, exercise resulted in increased levels of Lamin A and increased myonuclear stiffness in mice.

We conclude that exercise is associated with myonuclear remodelling, independently of age, which may contribute to the preservative effects of exercise on muscle function throughout the lifespan.

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1969 Dodge Hemi Daytona muscle car sold for record $1.43 million

It’s a winged car that flew higher than any before it.

A 1969 Dodge Hemi Daytona was sold at the Mecum Auctions event in Kissimmee, Florida, for a record $1.43 million, beating the $1.3 million mark set last May.

The Charger-based Daytona was built for just one year to homologate its aerodynamic body for NASCAR racing.

The Daytona and its Plymouth Superbird twin sibling are among the most iconic racing cars in history, with their signature nosecones and high rear wings engineered to dominate NASCAR’s high-speed ovals.

HERE’S WHEN THE LAST V8 DODGE MUSCLE CAR WILL BE REVEALED

This 1969 Dodge Hemi Daytona is the lowest-mileage example with a Hemi V8 left.
(Mecum Auctions)

They were so good that NASCAR quickly changed the rules to prohibit such extreme designs.

Just 503 Daytonas were built for the street in 1969 and many have been lost to history, as they were initially unpopular among buyers and treated with none of the respect they get today.

The Daytona was sold for a record $1.43 million.
(Mecum Auctions)

Of those only 70 were ordered with Dodge’s legendary 426 cubic-inch Hemi V8 and just 22 matched the motor to a four-speed manual transmission.

The Daytona auctioned by Mecum had both features and was the only one of the 22 painted T5 Copper Metallic with a white wing stripe and a tan interior, making it a truly unique car.

The car is one of 22 that were built with the Hemi engine and a four-speed manual transmission.
(Mecum Auctions)

It’s also the lowest-mileage Hemi Daytona with its original engine known to exist and has just 6,490 miles on its odometer.

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The car has had a notable list of owners over the years, including the late Los Angeles Times owner Otis Chandler, NFL Hall of Famer Kevin Greene and actor David Spade, whose character drove a beat-up Daytona in his comedy film “Joe Dirt”.

Only 70 Daytonas were built with the Hemi V8, most with an automatic transmission.
(Mecum Auctions)

Spade paid $900,000 for the car in 2015, which was an auction record for the model at the time.

It was one of a dozen Daytonas and Superbirds offered at Mecum by its most recent owner, collector Gary Edwards, with the rest selling at prices ranging from $247,500 to $742,500, but it wasn’t the only one that went for $1.43 million.

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Bobby Allison drove this NASCAR Daytona in several races.
(Mecum Auctions)

In a remarkable coincidence, a Daytona NASCAR racing car that was driven by Bobby Allison was offered at Kissimmee by a different consignor and sold for the exact same amount as the street car, which also set a record for the competition version of the car.

The Dodge Charger Daytona SRT will be the brand’s first all-electric car.
(Dodge)

Dodge will be bringing back the Daytona name in 2024 on a very different kind of car. The Charger Daytona SRT will be the brand’s first all-electric model and will replace its V8-powered cars, which will be discontinued at the end of 2023.

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Teen’s ‘pulled muscle’ turned out to be deadly cancer

It nearly turned into a deadlift.

A UK gym shark who thought he pulled a muscle while working out was flabbergasted to discover that the lump was actually a cancerous mass.

“The lump was quite big and about the size of an apple,” Tomas Evans, 18, told Kennedy News of the tumor.

The exercise enthusiast, who hails from Wrexham, Wales, had noticed a painful, apple-sized bump after a weight training session in June, but initially thought that it was just a “gym injury.”

“I went to the gym and two days later woke up with a big lump on my shoulder and it was causing me really bad pain,” Evans said. “I thought it had just been a muscle that had come out of place or something and it wasn’t.”

“It [the diagnosis] is a weird moment to describe because it didn’t really hit me straight away, it was kind of later on,” recalled Tomas Evans.
Kennedy News and Media

Although his booboo seemed innocuous, the Welsh lad’s concerned mother Rachael Tudor took her son to the doctor. They subsequently referred him to get shoulder and chest X-rays, and eventually a CT scan, which revealed something sinister.

While Tudor initially also thought her gym junkie son had just damaged something, she became alarmed after “he received a letter through the post to go in to discuss his results.”

“I instantly knew something wasn’t right,” said the distraught hospital technician, who later learned the “heartbreaking news” that her pride and joy had a “a mass the size of a fist in his chest.”

“He went straight for blood tests and a biopsy to see what exactly it was and we were faced with non-Hodgkin’s lymphoma or testicular cancer,” she lamented. “We came home and cried for the whole two weeks waiting on the test results.”

The cancerous mass in Evans’ chest had caused the lump to appear on his collarbone.
Kennedy News and Media
Evans with girlfriend Morgan, 19.
Kennedy News and Media

She added, “It was the most horrendous two weeks of our lives as the crippling anxiety of what on Earth we were facing was awful.”

Their worst fears were confirmed in July after doctors diagnosed Evans with Stage 2 Hodgkin lymphoma, a type of cancer that affects the lymphatic system, which plays a role in the body’s immune function. The disease makes white blood cells, also called lymphocytes, grow out of control, causing swollen lymph nodes and tumors throughout the body.

Hodgkin’s lymphoma is the most common cancer diagnosed in adolescents ages 15 to 19, according to Cancer.org.

The teen was devastated by the news. “It [the diagnosis] is a weird moment to describe because it didn’t really hit me straight away, it was kind of later on,” he recalled. “When they first told me there was ‘something there’ it was a shock but when they said what it actually was, I kind of knew what it would be, I had a feeling.”

“Getting the news your son has a mass the size of a fist in his chest is something no parent wants to hear, it was heart-breaking,” said mother Rachael Tudor, 38 (right).
Kennedy News and Media

Evans’ case was particularly difficult to diagnose as he exhibited no symptoms besides his collarbone lump — seen in accompanying X-rays — which was caused by the mass in his chest. Nonetheless, doctors believe he’d caught the tumor early as it had formed at the beginning of the year.

In order to combat the disease, the aspiring electrician started chemotherapy in September, Kennedy reported. Salvation came five weeks ago after his scans revealed that he was cancer free, but he nonetheless “decided to do the treatment until the end of February just to make sure that it’s gone everywhere.”

While he might’ve tested cancer-free, Evans said the chemo took its toll on his body. “I had to take a year out of college and stop work and being able to go out places is a lot more difficult now because I’m at a high risk of infections,” he said. “I get tired quite easily walking around places and just doing normal things, especially closer to when I’ve had the treatment as well.”

Evans had initially chalked up the lump to a pulled muscle.
Kennedy News and Media

In addition, the chemo has made Evans more susceptible to immune disorders. “Thomas has ended up in hospital a few times poorly with neutropenic sepsis and the worry of him catching infections has been our primary concern this time of year,” said his mother.

Despite the hurdles, Tudor said she’s glad “he’s on track and doing well,” adding that she is “so proud of him and how he’s coped.”

She even created a GoFundMe page to raise funds so her son and girlfriend Morgan can take a vacation to celebrate him completing treatment. They aim to donate the rest to a charity that helps lymphona sufferers.

Evans with his mom Rachael Tudor and sister Ava Tudor, 11.
Kennedy News and Media

In light of his epic saga, Evans is cautioning the public against ignoring even innocuous-seeming symptoms.

“I’d tell others who have symptoms to go and get checked out because I didn’t know, only that I hurt myself, otherwise I still wouldn’t know,” he said.

Read original article here

Teen’s ‘pulled muscle’ turned out to be deadly cancer

It nearly turned into a deadlift.

A UK gym shark who thought he pulled a muscle while working out was flabbergasted to discover that the lump was actually a cancerous mass.

“The lump was quite big and about the size of an apple,” Tomas Evans, 18, told Kennedy News of the tumor.

The exercise enthusiast, who hails from Wrexham, Wales, had noticed a painful, apple-sized bump after a weight training session in June, but initially thought that it was just a “gym injury.”

“I went to the gym and two days later woke up with a big lump on my shoulder and it was causing me really bad pain,” Evans said. “I thought it had just been a muscle that had come out of place or something and it wasn’t.”

“It [the diagnosis] is a weird moment to describe because it didn’t really hit me straight away, it was kind of later on,” recalled Tomas Evans.
Kennedy News and Media

Although his booboo seemed innocuous, the Welsh lad’s concerned mother Rachael Tudor took her son to the doctor. They subsequently referred him to get shoulder and chest X-rays, and eventually a CT scan, which revealed something sinister.

While Tudor initially also thought her gym junkie son had just damaged something, she became alarmed after “he received a letter through the post to go in to discuss his results.”

“I instantly knew something wasn’t right,” said the distraught hospital technician, who later learned the “heartbreaking news” that her pride and joy had a “a mass the size of a fist in his chest.”

“He went straight for blood tests and a biopsy to see what exactly it was and we were faced with non-Hodgkin’s lymphoma or testicular cancer,” she lamented. “We came home and cried for the whole two weeks waiting on the test results.”

The cancerous mass in Evans’ chest had caused the lump to appear on his collarbone.
Kennedy News and Media
Evans with girlfriend Morgan, 19.
Kennedy News and Media

She added, “It was the most horrendous two weeks of our lives as the crippling anxiety of what on Earth we were facing was awful.”

Their worst fears were confirmed in July after doctors diagnosed Evans with Stage 2 Hodgkin lymphoma, a type of cancer that affects the lymphatic system, which plays a role in the body’s immune function. The disease makes white blood cells, also called lymphocytes, grow out of control, causing swollen lymph nodes and tumors throughout the body.

Hodgkin’s lymphoma is the most common cancer diagnosed in adolescents ages 15 to 19, according to Cancer.org.

The teen was devastated by the news. “It [the diagnosis] is a weird moment to describe because it didn’t really hit me straight away, it was kind of later on,” he recalled. “When they first told me there was ‘something there’ it was a shock but when they said what it actually was, I kind of knew what it would be, I had a feeling.”

“Getting the news your son has a mass the size of a fist in his chest is something no parent wants to hear, it was heart-breaking,” said mother Rachael Tudor, 38 (right).
Kennedy News and Media

Evans’ case was particularly difficult to diagnose as he exhibited no symptoms besides his collarbone lump — seen in accompanying X-rays — which was caused by the mass in his chest. Nonetheless, doctors believe he’d caught the tumor early as it had formed at the beginning of the year.

In order to combat the disease, the aspiring electrician started chemotherapy in September, Kennedy reported. Salvation came five weeks ago after his scans revealed that he was cancer free, but he nonetheless “decided to do the treatment until the end of February just to make sure that it’s gone everywhere.”

While he might’ve tested cancer-free, Evans said the chemo took its toll on his body. “I had to take a year out of college and stop work and being able to go out places is a lot more difficult now because I’m at a high risk of infections,” he said. “I get tired quite easily walking around places and just doing normal things, especially closer to when I’ve had the treatment as well.”

Evans had initially chalked up the lump to a pulled muscle.
Kennedy News and Media

In addition, the chemo has made Evans more susceptible to immune disorders. “Thomas has ended up in hospital a few times poorly with neutropenic sepsis and the worry of him catching infections has been our primary concern this time of year,” said his mother.

Despite the hurdles, Tudor said she’s glad “he’s on track and doing well,” adding that she is “so proud of him and how he’s coped.”

She even created a GoFundMe page to raise funds so her son and girlfriend Morgan can take a vacation to celebrate him completing treatment. They aim to donate the rest to a charity that helps lymphona sufferers.

Evans with his mom Rachael Tudor and sister Ava Tudor, 11.
Kennedy News and Media

In light of his epic saga, Evans is cautioning the public against ignoring even innocuous-seeming symptoms.

“I’d tell others who have symptoms to go and get checked out because I didn’t know, only that I hurt myself, otherwise I still wouldn’t know,” he said.

Read original article here

Build Muscle, Lose Fat by Eating Wide Range of Protein: Nutritionist

  • A 35-year-old man submitted an average day’s eating to be reviewed for Insider’s Nutrition Clinic.
  • He told Insider he wants to build muscle and lose body fat.
  • If you’d like to have your diet reviewed by an expert, fill out this form. 

Brian, who wants to “build muscle and shed body fat,” submitted his eating routine to Insider’s Nutrition Clinic, where qualified dietitians and nutritionists offer advice on readers’ eating habits.

Brian, 35, said he lifts heavy weights five days a week, does 10-15 minutes of brisk walking before and after his workouts, and works a physically demanding job.

Registered associate nutritionist Eli Brecher told Insider Brian is doing the right thing by eating plenty of protein, but he should consider diversifying his sources with plant-based foods, whole foods, and fish as well as meat.

Brian’s weight lifting and active lifestyle are great, but he would benefit from incorporating some flexibility and mobility exercises into his regime, such as 10-15 minutes of stretching or yoga after his workouts or on the weekends, Brecher said.

Swap processed protein for plant-based or whole foods

For breakfast, Brian has a protein shake, a turkey sandwich, a high-protein yogurt, a trail mix bar, and a banana.

Two hours later, he eats a protein bar, he said.

Brecher said Brian’s overall diet contains a good amount of protein, which aligns well with his goals of building muscle and losing body fat.

However, he could benefit from swapping some of the processed sources, like bars and shakes, for plant-based or whole foods, she said. Brecher said this might provide Brian with more fiber to help with his goal of losing fat because fiber keeps you feeling full.

Brecher recommended making a breakfast smoothie with berries, spinach, oats, chia seeds, nut butter, and milk for more whole foods and nutrients.

Replace meat with tofu, lentils or chickpeas

Two to three hours after his morning snack, Brian has one pound of ground turkey or chicken with white rice, followed by another high-protein yogurt, and an orange.

“He may want to replace his lunchtime turkey or chicken with a tofu stir-fry or a lentil and chickpea stew,” Brecher said. “All wonderful sources of plant-based protein and fiber.”

Swapping white rice for brown would boost Brian’s fiber intake, while quinoa would provide minerals such as iron and magnesium, Brecher said.

“He could also top his yogurts with some extra protein in the form of a handful of walnuts, which are rich in antioxidants, and a sprinkle of pumpkin seeds, which are packed with zinc and vitamin K,” Brecher said.

Eat a variety of foods, including healthy snacks

Mid-afternoon, Brian has a snack such as almonds, trail mix, and/or a protein shake.

Nuts are a good source of healthy fats and also provide protein. Brecher suggested adding variety to his snacks by sometimes having carrot sticks with hummus or mashed avocado on wholegrain crackers with a sprinkle of mixed seeds.

For dinner, Brian eats chicken, turkey, or beef with white rice and vegetables, he said.

Brecher said Brian’s diet may lack diversity and suggested swapping meat for fish some days.

“Fish is a great source of protein and contains various essential vitamins and minerals, such as iodine and selenium, and oily fish including salmon, mackerel, and sardines are high in omega-3 fats, which are beneficial for cardiovascular health and brain health,” she said.

The advice in this article isn’t a substitute for a professional medical diagnosis or treatment.

Read original article here