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Tag Archives: molecular
The Molecular Mechanisms of Synaptic Variability in Neural Diversity – Neuroscience News
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Molecular Mystery Solved – Harvard Scientists Discover a Previously Unknown Way Cells Break Down Proteins – SciTechDaily
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Microsoft AI Research Introduce a Novel Deep Learning Framework Called Distributional Graphormer (DiG) to Predict the Equilibrium Distribution of Molecular Systems. – MarkTechPost
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‘Astonishing’ molecular syringe ferries proteins into human cells – Nature.com
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Webb Peers Into Frozen Heart of Molecular Cloud – Unveils Dark Side of Pre-Stellar Ice Chemistry
Webb has identified frozen forms of a wide range of molecules, including carbon dioxide, ammonia, and methane.
The discovery of diverse ices in the darkest regions of a cold molecular cloud measured to date has been announced by an international team of astronomers using
James Webb Space Telescope Unveils Dark Side of Pre-stellar Ice Chemistry
If you want to build a habitable planet, ices are a vital ingredient because they are the main source of several key elements — namely carbon, hydrogen, oxygen, nitrogen, and sulfur (referred to here as CHONS). These elements are important ingredients in both planetary atmospheres and molecules like sugars, alcohols, and simple
“Our results provide insights into the initial, dark chemistry stage of the formation of ice on the interstellar dust grains that will grow into the centimeter-sized pebbles from which planets form in disks,” said Melissa McClure, an astronomer at Leiden Observatory in the Netherlands, who is the principal investigator of the observing program and lead author of the paper describing this result. “These observations open a new window on the formation pathways for the simple and complex molecules that are needed to make the building blocks of life.”
In addition to the identified molecules, the team found evidence for molecules more complex than methanol, and, although they didn’t definitively attribute these signals to specific molecules, this proves for the first time that complex molecules form in the icy depths of molecular clouds before stars are born.
“Our identification of complex organic molecules, like methanol and potentially ethanol, also suggests that the many star and planetary systems developing in this particular cloud will inherit molecules in a fairly advanced chemical state,” added Will Rocha, an astronomer at Leiden Observatory who contributed to this discovery. “This could mean that the presence of precursors to prebiotic molecules in planetary systems is a common result of star formation, rather than a unique feature of our own solar system.”
By detecting the sulfur-bearing ice carbonyl sulfide, the researchers were able to estimate the amount of sulfur embedded in icy pre-stellar dust grains for the first time. While the amount measured is larger than previously observed, it is still less than the total amount expected to be present in this cloud, based on its density. This is true for the other CHONS elements as well. A key challenge for astronomers is understanding where these elements are hiding: in ices, soot-like materials, or rocks. The amount of CHONS in each type of material determines how much of these elements end up in
“The fact that we haven’t seen all of the CHONS that we expect may indicate that they are locked up in more rocky or sooty materials that we cannot measure,” explained McClure. “This could allow a greater diversity in the bulk composition of terrestrial planets.
Chemical characterization of the ices was accomplished by studying how starlight from beyond the molecular cloud was absorbed by icy molecules within the cloud at specific infrared wavelengths visible to Webb. This process leaves behind chemical fingerprints known as absorption lines which can be compared with laboratory data to identify which ices are present in the molecular cloud. In this study, the team targeted ices buried in a particularly cold, dense, and difficult-to-investigate region of the Chamaeleon I molecular cloud, a region roughly 500 light-years from Earth that is currently in the process of forming dozens of young stars.
“We simply couldn’t have observed these ices without Webb,” elaborated Klaus Pontoppidan, Webb project scientist at the Space Telescope Science Institute in Baltimore, Maryland, who was involved in this research. “The ices show up as dips against a continuum of background starlight. In regions that are this cold and dense, much of the light from the background star is blocked, and Webb’s exquisite sensitivity was necessary to detect the starlight and therefore identify the ices in the molecular cloud.”
This research forms part of the Ice Age project, one of Webb’s 13 Early Release Science programs. These observations are designed to showcase Webb’s observing capabilities and to allow the astronomical community to learn how to get the best from its instruments. The Ice Age team has already planned further observations, and hopes to trace out the journey of ices from their formation through to the assemblage of icy comets.
“This is just the first in a series of spectral snapshots that we will obtain to see how the ices evolve from their initial synthesis to the comet-forming regions of protoplanetary disks,” concluded McClure. “This will tell us which mixture of ices — and therefore which elements — can eventually be delivered to the surfaces of terrestrial exoplanets or incorporated into the atmospheres of giant gas or ice planets.”
These results were published in the January 23 issue of Nature Astronomy.
Notes
- A molecular cloud is a vast interstellar cloud of gas and dust in which molecules can form, such as hydrogen and carbon monoxide. Cold, dense clumps in molecular clouds with higher densities than their surroundings can be the sites of star formation if these clumps collapse to form protostars.
Reference: “An Ice Age JWST inventory of dense molecular cloud ices” by M. K. McClure, W. R. M. Rocha, K. M. Pontoppidan, N. Crouzet, L. E. U. Chu, E. Dartois, T. Lamberts, J. A. Noble, Y. J. Pendleton, G. Perotti, D. Qasim, M. G. Rachid, Z. L. Smith, Fengwu Sun, Tracy L. Beck, A. C. A. Boogert, W. A. Brown, P. Caselli, S. B. Charnley, Herma M. Cuppen, H. Dickinson, M. N. Drozdovskaya, E. Egami, J. Erkal, H. Fraser, R. T. Garrod, D. Harsono, S. Ioppolo, I. Jiménez-Serra, M. Jin, J. K. Jørgensen, L. E. Kristensen, D. C. Lis, M. R. S. McCoustra, Brett A. McGuire, G. J. Melnick, Karin I. Öberg, M. E. Palumbo, T. Shimonishi, J. A. Sturm, E. F. van Dishoeck and H. Linnartz, 23 January 2023, Nature Astronomy.
DOI: 10.1038/s41550-022-01875-w
The James Webb Space Telescope is the world’s premier space science observatory. Webb will solve mysteries in our solar system, look beyond to distant worlds around other stars, and probe the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and the Canadian Space Agency.
Shocking Study Finds Severe COVID-19 Linked With Molecular Signatures of Brain Aging
Scientists emphasize the value of neurological follow-up in recovered individuals.
It’s true that
In a series of experiments, scientists discovered that gene usage in the brains of patients with COVID-19 is similar to those observed in aging brains. The scientists, from Beth Israel Deaconess Medical Center (BIDMC), used a molecular profiling technique called
U.S. COVID Data Tracker CDC Data as of December 9, 2022.
“Ours is the first study to show that COVID-19 is associated with the molecular signatures of brain aging,” said co-first and co-corresponding author Maria Mavrikaki, PhD, an instructor of pathology at BIDMC and Harvard Medical School. “We found striking similarities between the brains of patients with COVID-19 and aged individuals.”
Mavrikaki and colleagues analyzed a total of 54 postmortem human frontal cortex tissue samples from adults 22 to 85 years old. Of these, 21 samples were from severe COVID-19 patients and one from an asymptomatic COVID-19 patient who died. These samples were age- and sex-matched to uninfected controls with no history of neurological or psychiatric disease. The scientists also included an age-and sex- matched uninfected
“We observed that gene expression in the brain tissue of patients who died of COVID-19 closely resembled that of uninfected individuals 71 years old or older,” said co-first author Jonathan Lee, PhD, a postdoctoral research fellow at BIDMC and Harvard Medical School. “Genes that were upregulated in aging were upregulated in the context of severe COVID-19; likewise, genes downregulated in aging were also downregulated in severe COVID-19. While we did not find evidence that the
Isaac H. Solomon, MD, PhD, of Brigham and Women’s Hospital, also contributed to this work, which was supported by the National Institute of Aging (NIA; R01 AG058816). The authors declare no conflicts of interest.