Tag Archives: Lessons

Taylor Swift Box Office: Lessons Learned From ‘Eras Tour’ Rollout Stumbles – Hollywood Reporter

  1. Taylor Swift Box Office: Lessons Learned From ‘Eras Tour’ Rollout Stumbles Hollywood Reporter
  2. Taylor Swift’s ‘Eras Tour’ Film Ignites Debate Over Movie Theater Etiquette Yahoo Entertainment
  3. 10 Reasons Taylor Swift: The Eras Tour’s Box Office Is So Impressive: Breaking Down The $123M Opening Screen Rant
  4. “Taylor Swift: The Eras Tour” Is Intimate, Colossal, and Slightly Disappointing The New Yorker
  5. Taylor Swift: The Eras Tour Movie Review: A Flawless, Spectacular Must-See! A Concert Film Like No Other, For A Pop Star Like No Other Koimoi
  6. View Full Coverage on Google News

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College Board advises Florida schools to not offer AP Psychology after state says lessons about gender identity and sexuality would violate state law – CNN

  1. College Board advises Florida schools to not offer AP Psychology after state says lessons about gender identity and sexuality would violate state law CNN
  2. Florida bans AP psychology over gender identity, sexual orientation lessons, College Board says WESH 2 News
  3. Florida effectively bans AP Psychology over gender, sexuality unit USA TODAY
  4. Pinellas County Schools to replace AP Psychology with alternative after Florida’s effective ban WFLA News Channel 8
  5. Florida effectively bans advanced psychology course over LGBTQ content – course developer Reuters
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Florida English professor fired after parent complaint over racial justice lessons – The Hill

  1. Florida English professor fired after parent complaint over racial justice lessons The Hill
  2. English professor in Florida says university terminated his contract after a complaint over his racial justice unit CNN
  3. Florida university fires professor after racial justice lessons prompted parent complaint Yahoo News
  4. South Florida professor says he was fired for ‘indoctrinating students’ by teaching racial justice WPLG Local 10
  5. Palm Beach Atlantic University professor fired after racial justice lesson prompts parent complaint WPTV News Channel 5 West Palm
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12 Health Lessons We Learned In 2022

It’s safe to say 2022 was a big year for health.

We started the year in a pandemic and will definitely enter 2023 in the same position; mpox, formerly known as monkeypox, sparked an unprecedented global outbreak; polio gave us a short-lived yet serious scare, prompting many of us to frantically ask our parents about childhood vaccinations; and reproductive rights for many people were taken away.

Amid the ups and downs, there were some important lessons that we think are worth revisiting before the new year.

Don’t cook your frozen chicken in an air fryer or microwave

A CDC report released this year suggested that people are getting sick in repeated outbreaks of food poisoning because they’re cooking frozen stuffed chicken products in appliances other than a conventional oven, like an air fryer, microwave, or toaster oven.

Studies have found that smaller, portable (and often cheaper) appliances may not be able to heat or cook frozen chicken enough to kill lurking bacteria, most often salmonella.

The CDC was primarily referring to breaded products, such as chicken cordon bleu or chicken Kyiv, that are “heat-treated,” meaning they’re cooked until the breading sets but not before the raw chicken inside is safe to eat.

When in doubt, always try to use a conventional oven if possible, and read the instructions on the product’s packaging. If you can’t use a conventional oven, make sure you follow the specific instructions for microwaves, toaster ovens, or air fryers.

If specific instructions for other appliances are not available, insert a meat thermometer in the center of the thickest part of the product to make sure it rises to 165 degrees Fahrenheit. Feel sick after eating the frozen chicken you made? Document everything you ate in the last week before symptoms began and visit a doctor.

Melatonin can be dangerous for babies and children

Bottles of sleep-inducing melatonin pills have become bedside staples, but its increased availability, particularly in easy-to-consume forms like gummies, has had serious, and in some cases deadly, consequences for the children who either accidentally get their hands on it or are given it by a caregiver.

A study published by the CDC this year found that melatonin overdoses in children increased 530% from 2012 to 2021, with the largest spike — a 38% increase — occurring from 2019 to 2020, when the COVID pandemic started.

Five children required mechanical ventilation and two children — a 3-month-old and a 1-year-old — died at home following melatonin poisoning.

Experts suggest that parents wait until their kids are at least 3 years old before giving them melatonin, and to first address poor sleep behaviors to ensure kids are getting quality sleep. If you suspect your child has consumed melatonin, you should immediately call poison control, especially if you don’t know how much they ingested.

And most importantly, store your melatonin where it’s out of reach for a child, like in a locked storage box.

Energy drinks can be associated with heart problems. Moderation is key.

Earlier this year, TikTokers were going viral after saying energy drinks were causing their heart problems. So we dug into the science to learn if that’s a thing.

Turns out it can be. Energy drinks have known health risks, particularly when consumed in large quantities or combined with alcohol. They’ve been linked to heart and blood vessel problems, like heart rhythm disturbances and increased heart rate and blood pressure. Experts believe the caffeine in these products may be to blame, but other ingredients like sugar could also play a role.

However, it’s less clear whether the drinks are linked to problems like coronary artery disease, which is generally due to a combination of genes and long-term lifestyle habits. And because a lot of things can contribute to heart disease, it’s difficult to pinpoint energy drinks as the reason for someone’s diagnosis or medical event.

Experts say that the occasional energy drink is fine, but consuming anything in excess is never a good thing. Not to mention little is known about the long-term effects of drinking these products on a regular basis.

You’re better off having a glass of water if you’re dehydrated, or a cup of coffee or tea if you want a boost in energy, experts say.

Kissing can elicit serious allergic reactions in some people with food allergies

After makeup artist and photographer Janelle Gonzalez posted a TikTok this year about her “kiss of death,” many people were shocked to learn that locking lips with someone who ate a certain food can trigger allergic reactions in some people with allergies.

That’s because food proteins can remain in a person’s mouth for a period of time after they eat; how long they hang out in there varies depending on several factors.

While intimately kissing someone who consumed a certain allergen isn’t a major source of dangerous reactions for most people, serious and potentially deadly reactions are definitely possible. More direct exposures like eating or touching the food is more likely to elicit an allergic response.

Allergists recommend anyone with allergies, especially severe ones, to carry an epinephrine injector pen (like an EpiPen) and to wear an item like a MedicAlert bracelet that lists their medical information in the event a reaction occurs in public.

You should also discuss your allergies with your partner or anyone else who may be cooking for you or sharing your food, as well as anyone you plan to share saliva or other bodily fluids with. You might as well clean your mouth as thoroughly as possible before kissing others too because it could help.

IV vitamin therapy isn’t well researched and could pose risks for some people

An episode of The Kardashians that aired this year revealed an excited Kendall Jenner and Hailey Bieber rolling up their sleeves to receive IV vitamin therapy. But experts were quick to question its validity, citing a lack of federal regulation and sound clinical research, as well as potential health risks for some people, particularly those with certain medical conditions.

IV therapy is touted as an efficient way to deliver fluid and nutrients into the body, pumping them directly into the bloodstream. However, there’s little proof that IV vitamin treatments work. A handful of studies show moderate benefits for asthma, inflammation, and fatigue, while a larger batch found the treatments have little to no impact, particularly for more serious health conditions like acute respiratory distress syndrome, cancer, sepsis, and stroke. (In those cases, people were given the treatments in medical settings.)

The biggest concern is that they are not FDA regulated or approved, so the kind of treatments you receive can vary widely depending on who is administering it.

While some people may feel more refreshed after a treatment, experts are doubtful the vitamins are responsible. Lying in a calm environment for a couple of hours while receiving IV therapy will help anyone relax. And if you’re dehydrated, the treatment may help you feel better by filling your blood vessels with the fluids they need.

Generally, nutritional deficiencies in the US are rare, so most people don’t need vitamins that they’re not already getting from their food, experts say. For those who do have nutritional deficiencies, a multivitamin pill will usually suffice. And if you are so dehydrated that you need an IV drip, a nonmedical clinic may not be the best place to get treatment.

Life-threatening brain injuries can happen to anyone and they’re not always easy to spot

Full House star and stand-up comedian Bob Saget died unexpectedly this year at the age of 65 after accidental blunt trauma to the head. His death was a reminder that potentially life-threatening brain injuries can happen to anyone and they’re not always easy to spot.

Neurology experts said that all it takes is a minor blow to a very specific part of the brain to cause serious damage, and that symptoms may look the same following mild or severe traumas. So it’s better to see a healthcare provider rather than let a potentially dangerous injury be overlooked.

Some serious symptoms to look out for include:

  • Enlarged pupils, especially if it’s just one
  • A headache that progressively gets worse or doesn’t go away
  • Slurred speech, weakness, numbness, or lack of coordination
  • Vomiting, convulsions, or seizures
  • Brief loss of consciousness
  • Unusual behavior, such as confusion, agitation, or restlessness

Otherwise, be wary of sensitivity to light, blurred vision, ringing in the ears, and change in sleep patterns after a head injury. It’s also always a good idea to observe anyone who injured their head for at least a couple of hours.

While some accidents are unavoidable, there are steps you can take to reduce the risk of a traumatic brain injury (like wearing a helmet when necessary). Prevention is key, experts say.

Gas stoves emit pollutants that could harm your health

Experts knew for some time that gas stoves emit pollutants that aren’t great for your health, but a study published this year found that methane, a potent greenhouse gas, leaks from appliances even while off.

The recent Stanford study also measured nitrogen dioxide levels. In just a few minutes of cooking, people who didn’t use range hoods or had poor ventilation, especially in smaller kitchens, were exposed to nitrogen dioxide levels that surpassed the EPA’s guidelines for one-hour outdoor exposure. (There are no regulations on indoor air pollution in the US.)

Whether these toxic pollutants can hurt your lungs depends on the level and length of exposure, but they are more harmful for some people than others, like children and people with respiratory illnesses or conditions, such as asthma and chronic obstructive pulmonary disease.

The amount of pollutants in the air may also depend on your gas stove’s cleanliness, general maintenance, and surrounding conditions, such as ventilation and kitchen size.

Generally, healthy people, or those with larger or well-ventilated kitchens where gasses can dissipate, don’t necessarily need to worry as much. But it’s always a good idea to turn exhaust fans or range hoods on while cooking, and leave them running for at least five minutes after cooking to collect any lingering pollutants.

You can also switch to an electric stove or conduction cooktop if you can. If not, regularly maintain and clean your gas stove, and consider having a professional inspect all pipe connections to make sure there aren’t any leaks.

Recent crowd crushes have been deadly. It’s important to know how to stay safe.

This year marked the one-year anniversary of the Astroworld Festival where 10 people died in a crowd surge during rapper Travis Scott’s performance in Houston. During Halloween festivities in downtown Seoul, at least 151 people were killed and dozens of others were injured after a large crowd began pushing forward in a narrow alley. Weeks before that, more than 125 people died in a stampede at an Indonesian soccer match.

Instances of large groups of people being trampled are relatively rare, but experts say more recent tragedies have been devastating in scale, and there are some precautions that people can take to help avoid these dangerous situations.

Here are some of the steps you can take if you want to avoid being trapped in a crowded environment:

  • Check out the facility ahead of time online or in person to examine where it’s located, the venue’s shape and size, where the exits are, as well as if it’s indoors or outdoors.
  • Go in a group and try to wear comfortable but distinctive clothing that helps everyone stand out.
  • Try to park close to an exit.
  • Bring plenty of fluids to drink.
  • Do not stand by the railings in front of a stage.
  • If you drop something, don’t try to pick it up.
  • Try to stay calm to preserve as much energy as possible.

Stuffing your socks with onions won’t cure your cold, flu, or RSV

This year’s surge in respiratory viruses like the flu and RSV, in addition to COVID, had (and still have) people on social media willing to try anything to cure their or their child’s symptoms.

People claimed that raw onions in your socks or a sick person’s bedroom can absorb viruses, bacteria, fungi, and possibly other “toxins” from the skin or air. Their premise is that onions might help congestion, cough, headaches, and other symptoms; some even claim the remedy helps with asthma and “negative energy.”

There is some evidence that your skin can absorb the sulfur-based compounds found in onions, and that onions have some antimicrobial properties — but not enough to provide any therapeutic benefits. There’s also no evidence that onions can absorb germs from the air.

Perhaps the reason some people say they feel better after sleeping with an onion in their sock or bedside table is because onions can reduce congestion in the same way that they make people cry thanks to a substance called thiosulfinates.

Generally, you’ll want to stick with the basic but effective measures of hand-washing and avoiding close contact with sick people to avoid getting sick yourself; flu shots are great too.

Luckily, stuffing your socks with onions carries little to no risk, but it’s important to understand that home remedies like this one cannot cure underlying infection, experts say. Onions are good for your health, though, so try including them in your diet.

Donating blood now is one of the best things you can do for future victims of gun violence

The harrowing truth is that school shootings drive blood donations, which was clear following the Uvalde massacre, where a shooter killed 19 students and two teachers this year.

Gunshot victims are approximately five times more likely to require blood transfusions. They require 10 times more blood units and are 14 times more likely to die than people seriously injured by motor vehicles, non-gun assaults, falls, or stabbings.

But while there’s a rush to donate after shootings, it’s the blood on the shelves before the violence happens that actually saves lives in the immediate aftermath. That’s because donated blood must go through a screening process that takes about 24 to 48 hours. Not to mention gun violence threatens an already low blood supply.

Since the beginning of the pandemic, there’s been a 10% decline in blood donations. Typically, blood centers like to have at least three days’ supply on hand to be able to meet the estimated needs of patients. This year and last, blood banks have been closer to the one- to two-day range of on-hand stock available to donate.

Emergencies happen every day, so consider donating blood when you can.

Breast implants can cause complications and, in rare cases, possibly cancer

This year, the FDA announced that it had received reports of about 50 cases of cancer in people who’ve had breast implants. The cancers, including squamous cell carcinomas (a common skin cancer) and lymphomas, were found in the scar tissue that forms around implants. In some people, the cancer had spread throughout the body.

Although the warning is concerning, experts said the low number of cases so far is reassuring — and that implants will continue to be inserted per usual. And that at this time, people with breast implants are not being encouraged to remove them.

But the news reminded people that breast implants are not lifetime devices, and that it’s important to monitor your breast implants with routine screenings and contact your plastic surgeon if you notice any abnormalities.

Generally, it’s recommended that people replace their breast implants every 10 years, but that can change depending on any problems that may occur with your implants. Otherwise, MRI screenings are recommended five to six years after your surgery and then every two to three years thereafter.

Katie Couric’s breast cancer diagnosis this year also served as a critical reminder to prioritize your routine mammograms, especially if you have dense breasts, which carry an additional risk factor for cancer and can make cancer more difficult to see on a mammogram.

Anyone can find themselves in abusive and manipulative relationships

In Netflix’s Bad Vegan and The Tinder Swindler, which aired this year, manipulative and otherwise abusive people exploit their successful, capable friends and romantic partners out of thousands, and in some cases millions, of dollars.

Not all relationships or dating experiences are this wild, but therapists and other experts said these stories can teach us a lot about abuse, intimidation, and gaslighting. What’s more, anyone, no matter where they come from or how they look or act, can find themselves in these kinds of relationships.

Because not all abusive relationships start out with obvious red flags, it may be helpful to know what they could look or feel like before they appear. Here are some signs you may be in an unhealthy relationship:

  • You’re second-guessing yourself many times a day or week.
  • You refrain from talking about your relationship with others to avoid judgment.
  • You feel like you’re not good enough.
  • You often question whether you’re being too sensitive or illogical.
  • You feel isolated from friends and family.
  • You take the blame for someone else’s behavior.

Here are some ways you can help someone else experiencing an abusive relationship:

  • Encourage them to speak to a therapist.
  • Guide them to resources where they can read about gaslighting.
  • Help them name what’s going on and write down their dialogue to see where the interaction veers into manipulation.
  • Remind them they can take a break from the relationship.
  • Listen to them share their story and offer your perspective.

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Lessons from Ukraine prompt top Taiwan museum to conduct ‘wartime response’ exercises

Written by Wayne Chang, CNNTaipei, Taiwan

In March, amid growing fears of a Russian attack on Ukraine’s cultural capital Lviv, staff at the city’s National Museum frantically packed up and hid thousands of its treasures.

Now, more than 5,000 miles away, another globally acclaimed institution is also preparing for the threat of a possible invasion.

Taiwan’s National Palace Museum, which boasts one of the world’s finest collections of Chinese imperial relics, is actively considering how it would protect its treasures if Beijing launched an attack. With China stepping up military pressure on the self-ruled island, the institution last week conducted its first ever “wartime response exercise” centered on evacuating its artifacts.

“The most important goal of this exercise is to let our staff know who is doing what if war breaks out, and how to react,” museum director Wu Mi-cha told CNN prior to the training session, adding that the institution was working with security and law enforcement agencies to refine its plans.

Staff members were walked through various scenarios and protocols during the exercise. Credit: National Palace Museum

The move comes after Wu revealed to lawmakers that he was unable to think of an ideal location to store the museum’s historical relics in the event of war. Pressed on his plans during a parliamentary meeting in mid-March, just weeks after Russia’s invasion of Ukraine, the director promised to devise an evacuation strategy and hold a drill in July.
China’s ruling Communist Party has long claimed Taiwan as its own territory and, despite having never controlled the island, has not ruled out taking it by force. In recent months, the self-governing democracy of 24 million people has faced growing military posturing from China, which has frequently sent warplanes near the island. In late June, the People’s Liberation Army (PLA) Air Force flew 29 aircraft into the territory’s air defense identification zone (ADIZ), the third-highest daily number of jets this year, according to Taiwan’s Ministry of National Defense.
China’s tacit support for Russia’s war on Ukraine has fueled speculation over its intentions with Taiwan, raising questions about how the world might react should it launch an attack. Concerns over a possible invasion have prompted the Taiwanese government to beef up its combat readiness and wartime preparation. Three other institutions in Taiwan — the National Taiwan Museum, the National Museum of Taiwan History, and the National Taiwan Museum of Fine Arts — confirmed to CNN that they are also devising evacuation strategies for their collections.

During last week’s exercise, about 180 staff members were taught how to respond to various scenarios, including how to request help from police or the military if security facilities are damaged and artifacts are seized by enemy forces. The special training will be added to existing safety drills (which are currently geared toward terrorist attacks and natural disasters in the earthquake-prone capital, Taipei) to boost staff’s overall ability to protect the collection, according to the museum.

The special training will be added to existing safety drills. Credit: National Palace Museum

In the case of an evacuation, the museum said it would focus on saving around 90,000 relics from its 700,000-strong collection, prioritizing artifacts of higher value and those that take up less space.

“Whether we need to evacuate the artifacts is subject to the commander-in-chief if there is a war. That said, the museum needs to prepare itself now, so that we can act immediately if we receive such orders,” museum officials said.

The museum would not disclose where the evacuated items would be stored, or how they would be transported there.

Surviving two wars 

Taiwan’s National Palace Museum is renowned for its vast collection of artifacts once housed at the Palace Museum in Beijing’s Forbidden City — treasures that have already survived two wars.

In the early 1930s, amid the prospect of a Japanese invasion of Beijing, the Chinese government moved parts of the imperial collection south to Shanghai and Nanjing. Later that decade, many of the artifacts were transported further inland to various locations in Sichuan province.

Parts of the imperial collection shown outside the Forbidden City’s Gate of Supreme Harmony in Beijing before they were moved south to Shanghai and Nanjing. Credit: National Palace Museum

Accompanied by a group of dedicated escorts, who faced constant bombing threats, the treasures were taken across the country via trains, trucks, horse carts and boats, being hidden in temples and caves along the way. In 1947, two years after Japan’s surrender to the Allies, the collection was reassembled in Nanjing.

The treasures were accompanied by escorts in their journey across China. Credit: Chuang Ling/National Palace Museum

But by that time, the bloody civil war between the then-ruling Kuomintang (KMT) and the insurgent Chinese Communist Party (CCP) had resumed. When defeated KMT forces retreated to Taiwan in 1949, they took with them over 600,000 items from the Palace Museum and other academic institutions — artifacts, artworks, books, maps and government records that would form the backbone of the Taipei museum’s collection.

After storing the items in a former sugar mill and a cave outside the Taiwanese city of Taichung, the KMT dredged tunnels deep into a hill on the outskirts of Taipei for the artifacts’ safekeeping. The National Palace Museum was eventually built at the base of the hill and, after opening in 1965, began exhibiting the collection to the public.

Museum staff at work, as parts of the imperial collection was temporarily
stored in a cave outside of Taichung. Credit: Chuang Ling/National Palace Museum

Museum’s political significance

For decades, the museum and its treasures have been imbued with political and national symbolism.

When the KMT retreated to Taiwan, it took what it considered to be the most valuable parts of the Palace Museum’s collection. Possessing these objects positioned the party as the custodian of Chinese culture and strengthened its claim of being China’s legitimate government, according to Hsu Ya-hwei, an art history professor at National Taiwan University.

One of Taiwan’s National Palace Museum’s most famous artifacts is the Jadeite Cabbage. Credit: Koji Sasahara/AP

Hsu added that this position grew more prominent during the Cultural Revolution of the 1960s and 1970s, when large swathes of China’s heritage were destroyed in Mao Zedong’s campaign against the “Four Olds”: old customs, culture, habits and ideas.

“It was during this time that the museum’s collection became very important, because it was the embodiment of Chinese culture,” Hsu said.

In recent decades, the National Palace Museum has expanded its scope beyond China, staging different types of exhibitions and opening a new southern branch, in rural Chiayi county, that showcases the interconnectivity of Asian cultures. But its collection of treasures from the mainland is what has “put Taiwan on the map,” Wu, the museum director, said.

“War has brought these artifacts to Taiwan,” he added. “It falls on us to protect these legacies that are invaluable to human civilizations.”

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‘Lessons learned’, but no details of royal review of Meghan bullying claims

LONDON, June 30 (Reuters) – Buckingham Palace says lessons have been learned following a review into bullying allegations made by royal staff against Meghan, the Duchess of Sussex, although it declined to give any details about the report’s conclusions.

The HR review was announced by the palace last March after the Times newspaper reported allegations had been made against Meghan, the American wife of Queen Elizabeth’s grandson Prince Harry, including that she had reduced some of her assistants to tears and treated others so badly that they had quit.

The couple issued a statement in response denying she had bullied anyone, and in an interview with Oprah Winfrey shortly afterwards, she accused the palace of “perpetuating falsehoods”.

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Michael Stevens, the queen’s treasurer who is known as Keeper of the Privy Purse, said the privately-funded review, which was carried out by an independent law firm, had been set up to examine the handling of the allegations and to improve practices across all the royal households.

“The review has been completed and recommendations on our policies and procedures have been taken forward,” Stevens told reporters. “But we will not be commenting further.”

The Times report said a senior aide to Harry and Meghan had raised a complaint in October 2018 alleging that the duchess had bullied some of her assistants, and that the prince had urged the aide to drop the issue which then never progressed.

The palace ordered a review, saying it was “very concerned”, and all those who participated, including current and former staff members, have been informed of its outcome. Royal sources declined to say whether the duchess herself had been involved.

“I think the objectives have been satisfied because lessons have been learned,” a senior royal source said.

OVERSPEND

Stevens was speaking as he gave details of the annual report into the queen’s taxpayer-funded spending and income, known as the Sovereign Grant, which was published on Thursday.

This showed that official expenditure for 2021-22 had been some 102 million pounds ($124 million), above the 86 million allocated for the royals’ official travel, property maintenance and the operating costs of the 96-year-old queen’s household.

Since 2017, the queen has received extra public money to pay for a 369 million pound 10-year refit of Buckingham Palace to replace ageing and dangerous electrical wiring and boilers, and Stevens said the royal household would draw upon reserves put aside in previous years to cover the additional outlay.

Another hit on the royal finances – which the palace says costs each Briton 1.29 pounds a year – was the reduction in additional money made mainly from ticket sales to visit royal palaces, down 50% at 10 million pounds compared with before the COVID-19 pandemic.

Overall, travel costs amounted to just under 2.5 million pounds, with the biggest expense being Prince William and his wife Kate’s tour of the Caribbean which cost 226,383 pounds.

“We are realistic that there will always be a tension between the travel involved with fulfilling the head of state and head of nation role, and meeting our environmental aspirations,” Stevens said.
($1 = 0.8231 pounds)

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Reporting by Michael Holden; Editing by Alex Richardson

Our Standards: The Thomson Reuters Trust Principles.

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Jeff Bridges on His New Outlook on Life and Lessons Learned After Battling Cancer and COVID – Jimmy Kimmel Live

  1. Jeff Bridges on His New Outlook on Life and Lessons Learned After Battling Cancer and COVID Jimmy Kimmel Live
  2. Jeff Bridges Recalls Cancer, COVID Battles and ‘Surrendering to the Idea that I Might Die’ Variety
  3. Jeff Bridges’ experience with COVID made cancer battle ‘look like nothing’ New York Daily News
  4. Jeff Bridges says he’s feeling much better after battling cancer and COVID-19: ‘It wiped me out’ Daily Mail
  5. Jeff Bridges faces mortality in new series ‘The Old Man’ — and in real life with lymphoma Star Tribune
  6. View Full Coverage on Google News

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The Vanishing Variants: Lessons from Gamma, Iota and Mu

In early 2021, scientists in Colombia discovered a worrisome new coronavirus variant. This variant, eventually known as Mu, had several troubling mutations that experts believed could help it evade the immune system’s defenses.

Over the following months, Mu spread swiftly in Colombia, fueling a new surge of Covid-19 cases. By the end of August, it had been detected in dozens of countries, and the World Health Organization had designated it a “variant of interest.”

“Mu was starting to make some noise globally,” said Joseph Fauver, a genomic epidemiologist at the University of Nebraska Medical Center and an author of a recent study on the variant.

And then it fizzled. Today, the variant has all but vanished.

For every Delta or Omicron there is a Gamma, Iota or Mu, variants that drove local surges but never swept to global dominance. And while understanding Omicron remains a critical public health priority, there are lessons to be learned from these lesser lineages, experts say.

“This virus has no incentive to stop adapting and evolving,” said Joel Wertheim, a molecular epidemiologist at the University of California San Diego. “And seeing how it did that in the past will help us prepare for what it might do in the future.”

Studies of the also-rans have shed light on surveillance gaps and policy blunders — providing more evidence that America’s international travel bans were not effective — and on what makes the virus successful, suggesting that in the early phase of the pandemic, transmissibility was more important than immune evasion.

The research also highlights how much context matters; variants that make an impact in some places never gain a foothold in others. As a result, predicting which variants will surge to dominance is difficult, and staying on top of future variants and pathogens will require comprehensive, nearly real-time surveillance.

“We can gain a lot by looking at the viral genomic sequence and saying, ‘This one is probably worse than another one,’” Dr. Wertheim said. “But the only way to really know is to watch it spread, because there are a whole lot of potentially dangerous variants that never took hold.”

The coronavirus is constantly changing, and most new variants never get noticed or named. But others raise alarms, either because they quickly become more common or because their genomes look ominous.

Both were true of Mu as it spread in Colombia. “It contained a couple of mutations that people had been watching very closely,” said Mary Petrone, a genomic epidemiologist at the University of Sydney and an author of the new Mu paper. Several of the mutations in its spike protein had been documented in other immune-evasive variants, including Beta and Gamma.

In the new study, which has not yet been published in a scientific journal, scientists compared Mu’s biological characteristics to those of Alpha, Beta, Delta, Gamma and the original virus. Mu did not replicate faster than any other variant, they found, but it was the most immune-evasive of the bunch — more resistant to antibodies than any known variant besides Omicron, Dr. Fauver said.

By analyzing the genomic sequences of Mu samples collected from all over the world, the researchers reconstructed the variant’s spread. They concluded that Mu had likely emerged in South America in mid-2020. It then circulated for months before it was detected.

Genomic surveillance in many parts of South America was “patchy and incomplete,” said Jesse Bloom, an expert in viral evolution at the Fred Hutchinson Cancer Research Center in Seattle. “If there had been better surveillance in those regions, possibly it would have been easier to make a faster assessment of how worried to be about Mu.”

Mu presented another challenge, too. It happened to have a type of mutation, known as a frameshift mutation, that was rare in coronavirus samples. Such mutations were flagged as errors when scientists, including Dr. Fauver, tried to upload their Mu sequences to GISAID, an international repository of viral genomes used to keep tabs on new variants.

That complication created delays in the public sharing of Mu sequences. The time that elapsed between when a virus sample was collected from a patient and when it was made publicly available on GISAID was consistently longer for Mu cases than for Delta cases, the researchers found.

“The genome itself was basically creating artificial surveillance gaps,” Dr. Fauver said. “It resulted, at least in our experience, in us not getting data out for weeks when normally we’re trying to get it out in days.”

(GISAID’s quality-control systems are important, the researchers stressed, and the repository has fixed the issue.)

Combine these surveillance gaps with Mu’s immune evasiveness and the variant seemed poised to take off. But that is not what happened. Instead, Mu radiated from South and Central America to other continents but did not circulate widely once it got there, the scientists found. “That was an indication that this variant was not as fit necessarily in maybe the North American and European populations as we had expected,” Dr. Petrone said.

That was likely because Mu found itself competing with an even more formidable variant: Delta. Delta was not as skilled at dodging antibodies as Mu, but it was more transmissible. “So, in the end, Delta spread more widely,” Dr. Bloom said.

Studying successful variants tells only half the story. “Variants that do not become dominant are, in a way, negative controls,” Dr. Petrone said. “They tell us what didn’t work, and, in doing so, help to fill in knowledge gaps around variant fitness.”

Delta overtook several immune-evasive variants besides Mu, including Beta, Gamma and Lambda. This pattern suggests that immune evasion alone was not enough to allow a variant to outdo a highly transmissible version of the virus — or at least it wasn’t during the early phase of the pandemic, when few people had immunity.

But vaccinations and multiple waves of infection have changed the immune landscape. A highly immune-evasive variant should now have more of an edge, scientists said, which is likely part of the reason Omicron has been so successful.

Another recent study suggested that in New York City immune-evasive Gamma tended to do better in neighborhoods with higher levels of pre-existing immunity, in some cases because they were hit hard in the first Covid wave. “We can’t view a new variant in a vacuum, because it comes about in the shadow of all of the variants that came before it,” said Dr. Wertheim, who was an author of the study.

Indeed, the clash of variants past reveals that success is highly dependent on context. For example, New York City may have been the birthplace of the Iota variant, which was first detected in virus samples collected in November 2020. “And so it got a foothold early on,” said Dr. Petrone. Even after the more transmissible Alpha variant arrived, Iota remained the city’s dominant variant for months, before eventually fading away.

But in Connecticut, where Iota and Alpha both appeared in January 2021, things unfolded differently. “Alpha just kind of took off immediately, and Iota didn’t stand a chance,” said Dr. Petrone, who led a study of the variants in the two regions.

A similar pattern is already beginning to play out with Omicron’s multiple lineages. In the United States, BA.2.12.1, a subvariant first identified in New York, has taken off, while in South Africa, BA.4 and BA.5 are driving a new surge.

That’s another reason to study variants that waned, said Sarah Otto, an evolutionary biologist at the University of British Columbia. A variant that was poorly matched for a certain time and place could take off in another. Indeed, Mu’s misfortune might have simply been that it emerged too soon. “There might not have been enough people that had immunity to really give that variant a boost,” Dr. Otto said.

But the next variant of concern could be a descendant of, or something similar to, an immune-evasive lineage that never quite took hold, she said.

Looking back at previous variants can also provide insight into what worked — or didn’t — in containing them. The new Gamma study, provides further evidence that international travel bans, at least as the United States implemented them, are unlikely to prevent a variant’s global spread.

Gamma was first identified in Brazil in late 2020. In May of that year, the United States barred most non-U.S. citizens from traveling into the country from Brazil, a restriction that remained in place until November 2021. Yet Gamma was detected in the United States in January 2021 and soon spread to dozens of states.

Because Gamma never came to dominate worldwide, studying its spread provided a “cleaner” picture of the effectiveness of travel bans, said Tetyana Vasylyeva, a molecular epidemiologist at the University of California San Diego and an author of the study. “When it comes to studying variants like, let’s say, Delta — something that has caused a major outbreak in every place — it is really difficult at times to find patterns, because it happens on a very large scale and very fast,” she said.

In an ongoing global health emergency, with a virus that changes fast, there is an understandable impulse to focus on the future, Dr. Fauver said. And as the world’s attention turned to Delta and then Omicron, he and his colleagues discussed whether to continue their study of old-news Mu.

“We were like, ‘Does anyone care about Mu anymore?’” Dr. Fauver recalled. “But we think there’s still room for high-quality studies that ask questions about previous variants of concern and try to look back on what happened.”

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Russia has “forgotten all the lessons of World War II”

Russian President Vladimir Putin could move to formally declaring war on Ukraine as soon as May 9, which would allow for the full mobilization of Russia’s reserve forces as they attempt to conquer eastern and southern Ukraine, US and Western officials believe.

May 9, known as Russia’s “Victory Day,” commemorates the Russians’ defeat of the Nazis in 1945. Western officials have long believed that Putin would leverage the symbolic significance and propaganda value of that day to announce either a military achievement in Ukraine, a major escalation of hostilities — or both. 

Officials have begun to hone in on one scenario, which is that Putin formally declares war on Ukraine on May 9. To date, Russian officials have insisted that the conflict was only a “special military operation” with the central goal of “denazification.” 

“I think he will try to move from his ‘special operation,’” British Defense Secretary Ben Wallace told LBC Radio last week. “He’s been rolling the pitch, laying the ground for being able to say ‘look, this is now a war against Nazis, and what I need is more people. I need more Russian cannon fodder.’”

Wallace added that he “would not be surprised, and I don’t have any information about this, that he is probably going to declare on this May Day that ‘we are now at war with the world’s Nazis and we need to mass mobilize the Russian people.’”

More context: A formal declaration of war on May 9 could galvanize Russian citizens and surge popular opinion for the invasion. It would also, under Russian law, allow Putin to mobilize reserve forces and draft conscripts, which officials say Russia desperately needs amid a growing manpower shortage. Western and Ukrainian officials have estimated that at least 10,000 Russian soldiers have been killed in the war since Russia invaded just over two months ago. 

Other options for May 9 include annexing the breakaway territories of Luhansk and Donetsk in eastern Ukraine, making a major push for Odesa in the south, or declaring full control over the southern port city of Mariupol. 

The US has “highly credible” intelligence reports that Russia will try to annex Luhansk and Donetsk “some time in mid-May,” the US Ambassador to OSCE Michael Carpenter said on Monday. There are also indications that Russia could be planning to declare and annex a “people’s republic” in the southeastern city of Kherson.

US State Department spokesman Ned Price said on Monday that there is “good reason to believe that the Russians will do everything they can to use” May 9 for propaganda purposes.

“We’ve seen the Russians really double down on their propaganda efforts, probably, almost certainly, as a means to distract from their tactical and strategic failures on the battlefield in Ukraine,” Price said at a State Department briefing.

Price added that he had “seen the speculation that Russia may formally declare war” on May 9, and said, “that would be a great irony if Moscow used the occasion of ‘Victory Day’ to declare war, which in itself would allow them to surge conscripts in a way they’re not able to do now, in a way that would be tantamount to revealing to the world that their war effort is failing, that they are floundering in their military campaign and military objectives.”

“I’m quite confident that we’ll be hearing more from Moscow in the lead up to May 9,” Price added. “I’m quite confident that you will be hearing more from the United States, from our partners, including our NATO partners, in the lead up to May 9 as well.”

 

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EXCLUSIVE: Battlefield series begins up-hill battle, feature reversions coming to next title as “valuable lessons” learned from Battlefield 2042

Before the launch of Battlefield 2042, EA and DICE were adamant that the title would be what fans wanted. Phrases like “well ahead of schedule,” “a love letter to fans,” and “have faith fam” were all said leading up to its launch.

However, the game ultimately failed to deliver for both fans and EA.

The title has been referred to internally “as a miss,” but work to make things right for players is still ongoing.

Despite the poor numbers that Battlefield 2042 has generated, there is a new Battlefield title in active development, and EA is providing the resources needed to bring back the franchise.

Although the next Battlefield game is in its pre-production stage, one inside source has said that “valuable lessons” have been learned following the release of Battlefield 2042.

“I think we’ll be reverting a lot of the changes we made in Battlefield 2042”, it was said.

Will we see 128 player matches in the next Battlefield game?

It’s too early to comment on specifics of the next game, but this comment could be referring to features such as the 128 player count and the specialists that have received harsh criticism since they were introduced.

Original plans for the overall series direction were to have Battlefield 2042 act as a foundation for the future, with the next Battlefield game being built upon it.

One former developer who recently left DICE following the launch of Battlefield 2042 had suggested that the next game was almost going to be like a “hero shooter,” with specialists becoming mercenaries.

It does seem like this plan may have changed, though, with recent playtest and feedback sessions focusing on the class system in Battlefield 2042.

Several people invited to these sessions believe that the changes coming to the specialist system in the next Battlefield game will tie specialists’ roles to classes more closely, which is a change the community wanted before Battlefield 2042 was even released.

Even though these changes will take time to implement into Battlefield 2042, they also give us a small insight into what the next title may bring.

My sources did confirm one thing: the next title is currently slated to have a modern/near-future setting.

The Future of Battlefield 2042

DICE is obligated to release four specialists and four battle passes for Battlefield 2042, and we know that at least one map, named Exposure, will be coming to the game this summer.

A large portion of DICE has now moved on to the next title in the series (as is industry standard). However, there’s still a strong and dedicated team working on Battlefield 2042 and its future content, despite concerns from the community that the game has been abandoned.

New modes, weapons, vehicles, maps, and more are still coming to Battlefield 2042 and are expected to be delivered throughout its life cycle. In addition, Ripple Effect is working hard to bring new content to Battlefield Portal soon.

Battlefield 2042 DLC is being worked on at DICE.

What’s currently unclear, though, is how the recent invasion of Ukraine by Russia will affect Battlefield’s lore and future content.

EA has removed Russia from its EA Sports titles in recent weeks. With Battlefield 2042’s game lore based on USA vs. Russia, it isn’t easy to see how that narrative can co-exist with future content, considering current world events.

As always, I’ll keep the updates coming as they are brought to me.

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