Tag Archives: increases

New Helldivers 2 Update Increases Level Cap, Adds Blizzards And Sandstorms, And More – Game Informer

  1. New Helldivers 2 Update Increases Level Cap, Adds Blizzards And Sandstorms, And More Game Informer
  2. Helldivers 2 Patch 01.000.200 Makes Significant Balance Changes, Adds More Planetary Hazards IGN
  3. New Helldivers 2 patch unleashes blizzards and sandstorms, and quietly increases the level cap to help you manage democracy even harder Gamesradar
  4. Helldivers 2’s new balance update softens those annoying civilian defences and stratagem cooldown modifiers, buffs heavy armour, and increases the level cap to 150 PC Gamer
  5. Huge ‘Helldivers 2’ Patch: New Level Cap, Massive Nerfs And Buffs Forbes

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Moldova conducts military exercises near Transnistria, adopts a defense strategy, and increases spending – Euromaidan Press

  1. Moldova conducts military exercises near Transnistria, adopts a defense strategy, and increases spending Euromaidan Press
  2. Moldovan president hails adoption of defence strategy citing Russia as threat Reuters
  3. Moldova’s About-Face: Reversing 30 Years of Military Neglect Amid War Next Door Voice of America – VOA News
  4. Moldova Holds Military Maneuvers Near Russia-Backed Breakaway Region Of Transdniester Radio Free Europe / Radio Liberty
  5. Hybrid Warfare, Russian Forces Within Borders Raise Concerns Amid ‘Historic Moment’ in Moldov VOA Zimbabwe

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Taking common painkillers alongside hormonal contraception increases risk of blood clots, study suggests – Daily Mail

  1. Taking common painkillers alongside hormonal contraception increases risk of blood clots, study suggests Daily Mail
  2. Use of common painkillers alongside hormonal contraception linked to heightened risk of blood clots Medical Xpress
  3. Venous thromboembolism with use of hormonal contraception and non-steroidal anti-inflammatory drugs: nationwide cohort study The BMJ
  4. Painkillers combined with contraceptive pill could increase risk of blood clots among women, study suggests Sky News
  5. Painkiller warning issued to anyone taking contraceptive medication Daily Record
  6. View Full Coverage on Google News

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Tiger Cub hedge fund Coatue drastically increases Big Tech holdings, doubles down on chip stocks – CNBC

  1. Tiger Cub hedge fund Coatue drastically increases Big Tech holdings, doubles down on chip stocks CNBC
  2. Hedge Fund Coatue Management Doubles Down On Meta, Nvidia, And Microsoft As Tech Stocks Regain Momentum – Microsoft (NASDAQ:MSFT), Netflix (NASDAQ:NFLX), Meta Platforms (NASDAQ:META), NVIDIA (NASDAQ:NVDA), Adobe (NASDAQ:ADBE), Benzinga
  3. Arrowstreet, Coatue Management among big hedge funds buying Meta in first quarter Yahoo Finance
  4. Loop Capital says Meta’s revenue outlook is getting brighter, sees more than 35% upside for tech giant CNBC
  5. Why Artificial Intelligence (AI) Pushed Meta Platforms Stock Higher Today The Motley Fool
  6. View Full Coverage on Google News

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A Drug That Increases Dopamine Can Reverse the Effects of Inflammation on the Brain in Depression

Summary: Levodopa, a drug commonly prescribed for the treatment of Parkinson’s disease that increases dopamine in the brain was found to reverse the effects of neuroinflammation on the reward system and improve symptoms associated with depression.

Source: Emory University

An Emory University study published in Molecular Psychiatry shows levodopa, a drug that increases dopamine in the brain, has potential to reverse the effects of inflammation on brain reward circuitry, ultimately improving symptoms of depression.

Numerous labs across the world have shown that inflammation causes reduced motivation and anhedonia, a core symptom of depression, by affecting the brain’s reward pathways.

Past research conducted by the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine has linked the effects of inflammation on the brain to decreased release of dopamine, a chemical neurotransmitter that regulates motivation and motor activity, in the ventral striatum.

In the study, researchers demonstrated that levodopa reversed the effects of inflammation on the brain’s functional connectivity in reward circuitry and anhedonia (inability to feel pleasure) in depressed individuals with higher C-reactive protein (CRP), a blood biomarker produced and released by the liver in response to inflammation.

Levels of inflammation can be easily measured by simple blood tests, like CRP, readily available in clinics and hospitals throughout the U.S.

The study included 40 depressed patients with a range of CRP levels from high to low who underwent functional brain scans on two visits after receiving in random order either placebo or levodopa, a drug often prescribed for disorders like Parkinson’s disease.

Levodopa improved functional connectivity in a classic ventral striatum to ventromedial prefrontal cortex reward circuit but only in patients with higher levels of CRP. This improvement in reward circuitry in depressed individuals with higher CRP also correlated with reduced symptoms of anhedonia after levodopa.

Levels of inflammation can be easily measured by simple blood tests, like CRP, readily available in clinics and hospitals throughout the U.S. Image is in the public domain

“This research demonstrates the translational potential for use of inflammation-related deficits in functional connectivity and could have important implications for the future investigations of precision therapies for psychiatric patients with high inflammation,” says principal investigator and senior author Jennifer C. Felger, Ph.D., associate professor of psychiatry and behavioral sciences, Emory School of Medicine.

Felger says the study findings are critical for two reasons. First, they suggest depressed patients with high inflammation may specifically respond to drugs that increase dopamine.

Second, Felger says these findings also provide additional evidence that functional connectivity in reward circuitry may serve as a reliable brain biomarker for the effects of inflammation on the brain.

“Moreover, as the effect of levodopa was specific to depressed patients with higher inflammation, this functional connectivity may be used to assess the responsiveness of the brain to novel treatments that might be targeted to this subtype of depressed patients in future studies and clinical trials,” says Felger.

About this psychopharmacology and depression research news

Author: Jennifer Johnson McEwen
Source: Emory University
Contact: Jennifer Johnson McEwen – Emory University
Image: The image is in the public domain

Original Research: Open access.
“Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study” by Mandakh Bekhbat et al. Molecular Psychiatry


Abstract

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Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study

Increased inflammation in major depressive disorder (MDD) has been associated with low functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia, relationships which may involve the impact of inflammation on synthesis and release of dopamine.

To test this hypothesis while establishing a platform to examine target engagement of potential therapies in patients with increased inflammation, medically stable unmedicated adult MDD outpatients enrolled to have a range of inflammation (as indexed by plasma C-reactive protein [CRP] levels) were studied at two visits involving acute challenge with the dopamine precursor levodopa (L-DOPA; 250 mg) and placebo (double-blind, randomized order ~1-week apart).

The primary outcome of resting-state (rs)FC in a classic ventral striatum to ventromedial prefrontal cortex reward circuit was calculated using a targeted, a priori approach.

Data available both pre- and post-challenge (n = 31/40) established stability of rsFC across visits and determined CRP > 2 mg/L as a cut-point for patients exhibiting positive FC responses (post minus pre) to L-DOPA versus placebo (p < 0.01).

Higher post-L-DOPA FC in patients with CRP > 2 mg/L was confirmed in all patients (n = 40) where rsFC data were available post-challenge (B = 0.15, p = 0.006), and in those with task-based (tb)FC during reward anticipation (B = 0.15, p = 0.013).

While effort-based motivation outside the scanner positively correlated with rsFC independent of treatment or CRP, change in anhedonia scores negatively correlated with rsFC after L-DOPA only in patients with CRP > 2 mg/L (r = -0.56, p = 0.012).

FC in reward circuitry should be further validated in larger samples as a biomarker of target engagement for potential treatments including dopaminergic agents in MDD patients with increased inflammation.

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Fighting in south increases sharply – DW – 01/20/2023

Fighting has “sharply increased” in the southern Ukrainian region of Zaporizhzhia, where the front has been largely stagnant for months, a senior Moscow-installed official in the area said on Friday.

“In the direction of Zaporizhzhia, the intensity of military activity has sharply increased,” the official, Vladimir Rogov, said on the Telegram social media platform.

Both Rogov and the Russian army said Moscow’s forces had seized the village of Lobkove, some 50 kilometres (30 miles) south of the Ukrainian-held regional capital also called Zaporizhzhia. 

According to Rogov, Russian forces had fired at Ukrainian positions with “tanks, mortar and artillery” in a dozen villages in the region. He had also announced a “local offensive” near the town of Orikhiv a day earlier. 

The Ukrainian army did not confirm the Russian claims, but said that “more than 20 settlements” in the region had been attacked.

The front in southern Ukraine has been considerably quieter recently than the east, with Moscow withdrawing from the major city of Kherson in November.

Also on Friday, Russia said it had captured a hamlet Klishchiivka near the town of Bakhmut, now the epicentre of fighting between Kyiv and Moscow’s forces. 

Klishchiivka, which had an estimated population of around 500 people before Moscow sent troops to Ukraine, lies southwest of Bakhmut, suggesting Russian forces were attempting to encircle the town.

Volunteers take aid to Bakhmut despite intense fighting

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Here are other updates on the war in Ukraine on Friday, January 20:

Inspections of Ukrainian grain ships halved since October

Inspections of ships carrying Ukrainian grain and other food exports have slowed to half their peak rate under a UN-brokered wartime agreement, creating backlogs in vessels meant to carry supplies to developing nations where people are going hungry, United Nations and Ukrainian officials say.

As the grain initiative got rolling in August, only 4.1 inspections of ships both heading to and leaving Ukraine took place each day on average, according to data from the Joint Coordination Center in Istanbul. In September, inspections jumped to 10.4 per day, then a peak rate of 10.6 in October. Since then, it’s been downhill: 7.3 in November, 6.5 in December and 5.3 so far in January.

“The hope had been that going into 2023, you would see every month the daily rate of inspection going up, not that you would see it halved,” USAID Administrator Samantha Power said at the World Economic Forum meeting in Davos.

More than 100 vessels are waiting in the waters off Turkey either for inspection or for their applications to participate to clear, with the waiting time of vessels between application and inspection averaging 21 days in the last two weeks, according to the UN.

Despite fewer average daily inspections, UN figures showed that more grain actually got through last month, up 3.7 million metric tons from 2.6 million in November. The coordination center explained that that was due to use of larger vessels in December.

Der Spiegel: German intelligence concerned about Ukraine’s Bakhmut losses

Germany’s foreign intelligence service, the BND, is concerned by the losses Ukraine is suffering in fighting against Russian forces in the eastern Ukrainian city of Bakhmut, news magazine Der Spiegel reported.

The Ukrainian army is losing a three-digit number of soldiers every day, the BND told a group of Bundestag lawmakers focused on security at a secret meeting this week, Der Spiegel reported. 

The BND also warned that the capture of Bakhmut by Russian forces would have significant consequences, as it would allow Russia to make further advances. 

Although Russian losses are considerably high as well, the report said this plays no role in the war tactics of the Russian army leadership as it is acting mercilessly around Bakhmut and throwing soldiers forward like cannon fodder.

UK joins international push to hold Russia accountable for Ukraine invasion

The UK said it joined a group of international partners pursuing criminal accountability for Russia’s invasion of Ukraine. The government said in a statement it had been invited by Ukraine to join the group and encouraged other G7 nations to also take part.

British Foreign Secretary James Cleverly said, “These atrocities must not go unpunished,” citing the deaths of soldiers and civilians and the displacement of millions of Ukrainians.

“That’s why the UK has accepted Ukraine’s invitation to join this coalition, bringing our legal expertise to the table to explore options to ensure Russia’s leaders are held to account fully for their actions,” he added.

The statement said Britain’s involvement would include assessing the feasibility of a new ‘hybrid’ tribunal, which it described as a specialized court integrated into Ukraine’s national justice system with international elements. 

Defense ministers discuss tanks for Ukraine at Ramstein

Defense ministers and senior military officers from around the world are weighing how best to support Ukraine, with the provision of powerful battle tanks high on the agenda, in talks at a US air base in western Germany.

US Defense Secretary Lloyd Austin invited the members of the Ukraine Contact Group to the conference at Ramstein, the largest US air base outside the United States, and urged them to “dig deeper” into their stocks to supply Ukraine with the weapons it needs to repel Russia’s invasion.

Pressure is mounting on Germany to send its Leopard 2 battle tanks to help Ukraine fight off the Russian invasion and to allow its allies to do so as well.

Berlin has so far refused to act unilaterally, insisting that it can only do so in concert with its allies, though domestically and abroad calls are growing louder to provide more modern and heavier weapons to Ukraine.

German and US defense chiefs meet in Berlin

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Czech Republic and Slovakia ready to send Leopard tanks — reports 

The Czech government supports the idea of supplying Ukraine with Leopard 2 tanks that it received recently from Germany, the Frankfurter Allgemeine Zeitung reported citing diplomatic sources.

Both the Czechs and the Slovaks have already supplied Ukraine with dozens of their own Soviet-era tanks, but now they want to hand over the Leopards they received from Germany in a so called ring exchange. 

In this exchange, Germany would replace the Soviet-era tanks with refurbished Leopard 2A4s. The first of these tanks were delivered to the Czech Republic and Slovakia in December, and crew training has already begun.

First UN aid convoy reaches sites near Ukraine’s Soledar

A UN spokesperson said that a three-truck humanitarian convoy had brought aid to around 800 people close to Soledar in Ukraine’s eastern Donetsk region.

The supplies of food, water, hygiene and medicines are the first such UN convoy to reach the area where intense fighting between Ukrainian and Russian forces is taking place.

Jens Laerke from the United Nations Office for the Coordination of Humanitarian Affairs said that the vehicles, which departed from Dnipro, were being offloaded on Friday morning in areas controlled by the Ukrainian government, without giving an exact location.

Russian forces say they control Soledar, while Ukrainian sources say the military is still fighting in the area.

US media report CIA director met Zelenskyy in Kyiv last week

CIA Director William Burns met with Ukrainian President Volodymyr Zelenskyy late last week in Kyiv to discuss what he believes Russia is planning in the weeks and months ahead, The Washington Post and other outlets reported.

A US official told the paper, “Director Burns traveled to Kyiv where he met with Ukrainian intelligence counterparts as well as President Zelenskyy and reinforced our continued support for Ukraine in its defense against Russian aggression.”

Burns, a former ambassador to Russia, stressed “the urgency of the moment on the battlefield” but communicated that “at some point assistance would be harder to come by.”

Sources told the paper that Zelenskyy and his aides had the impression from the talks that the US administration still strongly supports the $45 billion (€41.5 billion) in emergency funding passed by Congress in December. 

That funding expected to last through July or August.

Poland ready to send Ukraine tanks regardless of German permission

Poland could send Leopard 2 tanks to Ukraine even without Germany’s re-export approval, a Polish deputy foreign minister said.

“I do not rule out that we are ready to take such a step,” Pawel Jablonski told radio station RMF FM. Jablonski was referring to the possibility of sending tanks to Ukraine even if Germany opposes it.

He said he hoped Poland would encourage Berlin “also to do so themselves.”

On Wednesday, Polish Prime Minister Mateusz Morawiecki suggested Warsaw could send Leopard 2 tanks to Ukraine as part of a wider coalition, should Germany fail to give its approval.

Finland to send heavy artillery to Ukraine

Finland announced a new donation of more than €400 million euros ($434 million) worth of defense equipment for Ukraine, not including Leopard 2 heavy tanks, which it said it could also send if there is an agreement with allies.

It is the Nordic country’s twelfth package of defense materiel to Ukraine. The previous 11 aid packages had a combined value of €190 million.

Miika Pynnonen, special adviser to Finland’s defense minister, said a decision on donating Leopard 2 tanks, of which Finland has some 200, would be taken separately, following discussions with allies at Ramstein air base in Germany.

Finland had earlier indicated it could send the German-made Leopard tanks if there were an agreement among allies.

The ministry also said Finland would sign a so-called statement of intent with Sweden on support for Ukraine to make sure the aid “would not endanger the national defense of the two countries.”

“Finland supplies defense materiel to Ukraine, and Sweden expresses its readiness to support Finland as necessary,” the statement said.

Ukraine says detained seven ‘Russian agents’

Ukraine said it had detained seven “Russian agents” suspected of handing coordinates to Moscow’s forces to carry out strikes in the city of Dnipro, where dozens of civilians were recently killed in a missile attack.

“The detainees gave the Russians the coordinates of critical infrastructure facilities,” Ukraine’s security services said in a statement. 

“Information about the possible involvement of the detainees in the Russian missile attack on a residential building in Dnipro on January 14, 2023 is currently being checked,” the statement added.

Russian Wagner group officially registers as ‘consultancy’

In its latest intelligence report, the UK Ministry of Defense said the Russian mercenary Wagner group formally registered in Russia as a legal entity, marking a new development in the history a traditionally secretive group.

Wagner now commands up to 50,000 fighters in Ukraine and has become “a key component” in Russia’s war against its neighbor, the UK ministry said.

Wagner cited its business activities as “management consultancy,” in the filing, which was made on December 27. No mention of its paramilitary activities appeared.

It is not clear to what extent the registration would be used to manage the group’s mercenary activities. Private security and military companies are technically illegal in Russia. 

Ukrainians wrap up landmine clearance exercises in Cambodia

A group of 15 Ukrainian deminers wrapped up a week of training in Cambodia, where experts who have cleared minefields from one of the most mined countries on the planet shared their expertise with the relative newcomers to the dangerous job.

Oum Phumro, deputy secretary general of the Cambodian Mine Action Center said the training will continue with regular video conference calls and a team of three to five Cambodian experts will travel to Poland in April to train more Ukrainians.

He also said Cambodia was giving Ukraine experienced sniffer dogs and training them on how to use them to detect mines.

Cambodia is still strewn with mines from three decades of war and internal conflicts that ended in 1998, while the conflict in Ukraine is a new one since the Russian invasion last year.

Germany promises Ukraine €52 million more in reconstruction aid

Germany’s Development Minister Svenja Schulze promised Ukraine an additional €52 million ($56 million) for reconstruction during a visit to the southern Ukrainian port city of Odesa.

“We are in the midst of war to rebuild Ukraine into a free, independent Ukraine,” she said on Thursday. The visit was kept secret until Friday morning for security reasons.

The additional millions in aid for Ukrainian municipalities is to go toward heating, electricity generators, medical care and administrative costs.

German development minister visits Odesa, renews aid promise

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In 2022, the German Development Ministry (BMZ) provided Ukraine with around €600 million in aid.

Schulze was on her second visit to Ukraine since the Russian invasion in February last year, after making a trip to Kiev at the end of May. She was accompanied by Ukrainian Deputy Prime Minister and Infrastructure Minister Olexandr Kubrakov.

Nearly one-fifth of Western companies remaining in Russia are German

Despite widespread outrage over Russia’s war against Ukraine, fewer Western companies than many would believe have actually left Russia, according to a Swiss study.

Politico reported that researchers at the University of St. Gallen and at the IMD institute in Lausanne in Switzerland found that less than 10% of companies from the EU and G7 nations with Russian subsidiaries had divested.

When Moscow launched its invasion, 1,404 companies based in the EU and the G7 counted a total of 2,405 subsidiaries that were active in Russia, the study showed.

By late November, only 120, or about 8.5% of those companies, had divested at least one subsidiary in Russia. There were more confirmed exits from US-headquartered companies than firms based in Europe and Japan.

Fewer than 18% of the US subsidiaries operating in Russia were completely divested in after last year’s February 24 invasion.  By contrast, 15% of Japanese firms and only 8.3% of EU firms had divested from Russia, it said.

Of those who continue to do business in Russia, 19.5% are German and 12.4% are US-owned.

dh/ar (AP, AFP, dpa, Reuters)

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Malaysia landslide death toll increases to 23, 10 missing

Rescue teams searching for missing campers caught in Friday’s landslide at an unlicensed campsite in Malaysia recovered the bodies of a woman and a boy, raising the death toll to 23.

The landslide in Batang Kali, a popular hilly area about 30 miles north of Kuala Lumpur, tore through the campsite while people slept in their tents, killing the victims including six children.

Of the 94 people caught in the slide, 61 were safe and 10 still missing, according to the Selangor state fire and rescue department.

Search and rescue operations continued for a second day on Saturday after a halt overnight due to heavy rains that have complicated the operation, said the state fire and rescue chief, Norazam Khamis.

“We have to be careful because there is strong water flow from the top and in the soil. This complicates search operations because the ground is soft,” he said.

94 people were reported to have been in the landslide with 61 survivors.
REUTERS

A total of 135 responders resumed scouring through thick mud and downed trees around 8.30 am with the assistance of excavators and seven canines, according to Norazam.

Norazam told reporters chances were slim of more missing people being able to survive the lack of oxygen and the weight of the mud.

An initial investigation showed an embankment of about 588,578 cubic meters of earth had collapsed. The earth fell from an estimated height of 100 ft and covered an area of about an acre.

The Malaysia National Disaster Management Agency said they have identified six victims. The youngest was a 9-year-old boy.

Prime Minister Anwar Ibrahim told reporters late on Friday the government would provide $2,260 in aid to families of every person killed in the tragedy, while survivors would receive $226 per household.

The landslide swept through a campground early Friday morning, 30 miles from the Malaysian capital.
REUTERS

The Forestry Department in several states ordered the closure of campsites and hiking and off-road trails considered as high risk following the disaster.

Landslides are common in Malaysia, but typically only after heavy rains. Flooding occurs often, with about 21,000 people displaced last year by torrential rain in seven states.

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Diet Rich in Ultra-Processed Foods Increases Dementia Risk

  • New research suggests that a diet rich in ultra-processed foods could lead to a higher risk of developing dementia.
  • Researchers found that those who consumed 28% or more of their calories from ultra-processed foods had a higher risk of dementia.
  • Experts explain key takeaways from this new study.

We all know that certain foods are better for us than others, and that eating healthy is key to feeling our best. However, new research shows just how much our diet can truly affect not only our body but our brain as well. A new study found that eating ultra-processed foods actually increases your risk for dementia.

Dementia is not a specific disease but rather a general term for the impaired ability to remember, think, or make decisions, which interferes with everyday activities. Alzheimer’s disease is the most common type of dementia. And, according to the CDC, of those at least 65 years of age, there was an estimated 5 million adults with dementia in 2014. That number is projected to be nearly 14 million by 2060.

A study published in JAMA Neurology and presented at the 2022 Alzheimer’s Association International Conference, followed 10,775 individuals for 10 years. The participants included both men and women, with an average age of 51. Participants filled out a food frequency questionnaire and reported their calorie intake during the study. At the end of the 10-year period, participants were assessed on changes in cognitive performance over time by utilizing multiple cognitive-related tests.

Researchers determined that those who consumed 28% or more of their calories from ultra-processed foods had a higher risk of dementia. In an average diet of 2000 calories, this equates to only 400 calories each day coming from ultra-processed foods—which is not much.

This is not the first study drawing a connection between ultra-processed foods and larger health concerns, and it’s likely not the last. Earlier this year, researchers found that ultra-processed foods lead to cancer, premature death, and heart disease. And, there have been other studies linking ultra-processed food with dementia, including a study that was published in Neurology in July.

What are ultra-processed foods?

The study defined ultra-processed foods as “industrial formulations of food substances (oils, fats, sugars, starch, and protein isolates) that contain little or no whole foods and typically include flavorings, colorings, emulsifiers, and other cosmetic additives.”

In general, “If a food is easy, inexpensive, packaged, and lasts on the shelf for years—or includes artificial colors or flavors or synthetic additives—it may be an ultra-processed food,” says Jackie Newgent, R.D.N., C.D.N., plant-forward culinary nutritionist and author of The Clean & Simple Diabetes Cookbook. “They’re manufactured formulations or substances, such as protein isolates, refined oils, and processed sugars and starches in which little ‘whole food’ value remains.”

Some examples of ultra-processed foods, according to Newgent, include:

  • Sugar-sweetened drinks
  • Packaged cookies
  • Breakfast cereals made from refined grains
  • Snack chips or pretzels made from refined grains
  • Processed red meats, like bacon and hot dogs

How do ultra-processed foods affect health?

Frequently eating ultra-processed foods is less healthy than fresh foods, says Amit Sachdev, M.D., director of the division of neuromuscular medicine at Michigan State University.

Part of the problem is that you may be short-changing your health based on what you’re not getting, says Newgent. “A concern is not that you occasionally enjoy some ultra-processed foods in your eating plan; it’s if you’re eating them instead of wholesome nutrient-rich foods—and you’re consistently eating ultra-processed foods over time.”

How do ultra-processed foods affect our brain health and contribute to dementia risk?

From previous studies, “regular intake of ultra-processed foods seems to be associated with increased inflammation in the brain,” explains Newgent.

The best link we have between dementia risk and diet is through overall wellness, says Dr. Sachdev. “A healthy body will lead to a healthy brain.” And, a diet that includes fresh foods is typically better balanced and more nutritious, he adds.

The bottom line

“What you eat really does matter, for the brain and the body,” says Dr. Sachdev. But, as Newgent explains, we know that no one is perfect. “If you don’t eat any ultra-processed foods, that’s amazing,” she says, “However, the most realistic advice for most is to aim for limiting, not eliminating ultra-processed foods.” Generally speaking, know that you can occasionally enjoy a handful of refined grain pretzels or chips; but the key is a handful not a bowlful—and occasionally not daily, says Newgent.

In the end, it’s all about balance. But, this new research just goes to show how vital healthy eating is for every part of our body—especially our brains. As far as further studies to come, Dr. Sachdev explains, “We need to better understand what is toxic to the brain and body, so we can help to eliminate it.”

So until we know how to treat dementia, we will have to do our best to prevent it from developing by starting with a healthy lifestyle and diet with minimal ultra-processed foods.

Madeleine, Prevention’s assistant editor, has a history with health writing from her experience as an editorial assistant at WebMD, and from her personal research at university. She graduated from the University of Michigan with a degree in biopsychology, cognition, and neuroscience—and she helps strategize for success across Prevention’s social media platforms. 

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ECB hikes rates, sees significant increases ahead as it announces plan to shrink balance sheet

President of the European Central Bank Christine Lagarde attends a hearing of the Committee on Economic and Monetary Affairs in the European Parliament on November 28, 2022 in Brussels, Belgium.

Thierry Monasse | Getty Images News | Getty Images

The European Central Bank opted for a smaller rate hike at its Thursday meeting, taking its key rate from 1.5% to 2%.

It also said that from the beginning of March 2023 it would begin to reduce its balance sheet by 15 billion euros ($16 billion) per month on average until the end of the second quarter of 2023.

It said it would announce more details about the reduction of its asset purchase program (APP) holdings in February, and that it would regularly reassess the pace of decline to ensure it was consistent with its monetary policy strategy.

The widely-expected 50 basis point rate rise is the central bank’s fourth increase this year.

It hiked by 75 basis points in October and September and by 50 basis points in July, bringing rates out of negative territory for the first time since 2014.

The euro rose from a 0.5% loss against the dollar to a 0.4% gain following the announcement, but European equities in the Stoxx 600 index plunged 2.4%.

“The Governing Council judges that interest rates will still have to rise significantly at a steady pace to reach levels that are sufficiently restrictive to ensure a timely return of inflation to the 2% medium-term target,” the ECB said in a statement.

The central bank said it was working on inflation forecasts that had been “significantly revised up,” and sees inflation remaining above its 2% target until 2025.

It now expects average inflation of 8.4% in 2022, 6.3% in 2023, 3.4% in 2024 and 2.3% in 2025.

However, it sees a recession in the region being “relatively short-lived and shallow.”

It comes after the latest inflation data for the euro zone showed a slight slow in price rises in November, although the rate remains at 10% annually.

At a press conference following the announcement, ECB President Christine Lagarde told CNBC’s Annette Weisbach: “One of the key messages, in addition to the hike, is the indication that not only will we raise interest rates further, which we had said before, but that today we judged that interest rates will still have to rise significantly, at a steady place.”

“It is pretty much obvious that on the basis of the data that we have at the moment, significant rise at a steady pace means we should have to raise interest rates at a 50 basis point pace for a period of time,” she said.

Regarding the announcement on quantitative tightening, she said the ECB wanted to follow the principles of being predictable and measured.

The central bank’s decision to make on average 15 billion euro reductions in its APP over four months represents roughly half the redemptions over that period of time, and was based on advice from its market team and all central banks and other officials involved in its decision making, Lagarde explained.

“It seemed an appropriate number in order to normalize our balance sheet, bearing in mind that the key tool is the interest rate,” she said.

The U.S. Federal Reserve on Wednesday increased its main rate by 0.5 percentage points, as did the Bank of England and Swiss National Bank on Thursday morning.

“In contrast to the Bank of England, this is a hawkish hike, given the language on [quantitative tightening] and a definitive start date,” said analysts at BMO Capital Markets.

However, they noted the ECB was lagging other central banks in reducing its balance sheet and that reinvestments under its pandemic emergency purchase program would continue.

“The language in the statement has an operational feel to it, and the Bank is leaving the path of QT open-ended,” they wrote in a note.

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SEE IT: Thanksgiving travelers faced major price increases for airfare, hotels

Thanksgiving travelers faced major price hurdles this holiday.

Decades-high inflation, coupled with a continued travel rebound stemming from the COVID-19 pandemic, is leading to higher prices for just about everything travel-related, including airfare, hotels and gas. Inflation cooled slightly in October, but still hit 7.7%.

AS THANKSGIVING TRAVEL PRICES FORCE AMERICANS TO STAY HOME OR BREAK THE BANK, PEOPLE IN NEW JERSEY SOUND OFF

Domestic flights booked in early November for the week of Thanksgiving averaged 48% higher than 2021, according to Kayak.
(Fox News)

The average price for a domestic round-trip flight the week of Thanksgiving was $468 if it was booked in early November, with prices only increasing as the month went on, according to Kayak. That marks a 48% increase from 2021. And another headache: United Airlines expects the holiday will be its busiest period since the beginning of the pandemic. 

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Things don’t get better once travelers reach their destinations, either. The average hotel stay for Thanksgiving cost $173 per night as of early November — a 14% increase from last year, according to Hopper.

Thanksgiving hotels cost 14% more than last year if a room was booked in early November, according to Priceline.
(Fox News)

Car rental prices, at least, had a small drop compared to last year — down to $84 a day for Thanksgiving, reflecting a 1% drop from 2021 when demand far outpaced supply, according to Priceline. But that price is still 62% more than what a rental car cost before the pandemic.

Rental car prices for Thanksgiving increased 62% from 2019 if it was booked in early November, according to Priceline.
(Fox News)

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Most travelers, though, are expected to travel by car, with AAA predicting that nearly 49 million will hit the road.

Gas prices have increased slightly since last year. A regular gallon cost $3.64 on average Tuesday — up about 24 cents compared to 2021, but down significantly from the summer peak of $5, according to AAA.

Overall, AAA predicts there will be nearly 55 million travelers this Thanksgiving — nearly 98% of the pre-pandemic volume, and the third busiest since 2000 when the group started tracking the data.

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