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Entertainment

Sheryl Lee Ralph, Chris Stapleton and Babyface to perform in 2023 Super Bowl pre-show

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CNN
 — 

The full entertainment lineup for the 2023 Super Bowl has arrived.

In addition to Rihanna’s highly anticipated halftime show performance, a number of additional Hollywood heavyweights are joining the major sporting event as pre-show performers.

The NFL announced on Tuesday that Emmy-winning actor Sheryl Lee Ralph will perform “Lift Every Voice and Sing” in the pre-show. The “Abbott Elementary” star notably sang on stage while accepting her Emmy award in 2022.

Joining Ralph in the pre-show festivities is Grammy-winning country music artist Chris Stapleton, who has been tapped to sing the National Anthem. R&B crooner Kenneth “Babyface” Edmonds will also perform, with a rendition of “America the Beautiful.”

Each performer will have talent accompanying them to provide American Sign Language (ASL) on behalf of the National Association of the Deaf (NAD), according to a release from the NFL.

Oscar winner Troy Kotsur will sign the national anthem alongside Stapleton. Kotsur won a supporting actor Academy Award in 2022 for his work in “CODA,” becoming the second Deaf person ever to win an acting Oscar after Marlee Matlin.

In case you need any more Super Bowl LVII hype before the February 12 game, here’s our gentle reminder that Rihanna released a teaser on her Instagram to tide you over until then.



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Health

A few minutes of brisk activity can help your brain, study finds

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Editor’s Note: Seek advice from a health care provider before starting a workout program.



CNN
 — 

What if you could look at all the things you do daily — walking from room to room, preparing a presentation at your desk, running up and down stairs to deliver folded laundry or taking a jog around the block — and know which ones will best help or hurt your brain?

A new study attempted to answer that question by strapping activity monitors to the thighs of nearly 4,500 people in the United Kingdom and tracking their 24-hour movements for seven days. Researchers then examined how participants’ behavior affected their short-term memory, problem-solving and processing skills.

Here’s the good news: People who spent “even small amounts of time in more vigorous activities — as little as 6 to 9 minutes — compared to sitting, sleeping or gentle activities had higher cognition scores,” said study author John Mitchell, a Medical Research Council doctoral training student at the Institute of Sport, Exercise and Health at University College London, in an email.

Moderate physical activity is typically defined as brisk walking or bicycling or running up and down stairs. Vigorous movement, such as aerobic dancing, jogging, running, swimming and biking up a hill, will boost your heart rate and breathing.

The study, published Monday in the Journal of Epidemiology & Community Health, found doing just under 10 minutes of moderate to vigorous exertion each day improved study participants’ working memory but had its biggest impact on executive processes such as planning and organization.

The cognitive improvement was modest, but as additional time was spent doing the more energetic workout the benefits grew, Mitchell said.

“Given we don’t monitor participants’ cognition over many years, this may be simply that those individuals who move more tend to have higher cognition on average,” he said. “However, yes, it could also imply that even minimal changes to our daily lives can have downstream consequences for our cognition.”

Steven Malin, an associate professor in the department of kinesiology and health at Rutgers University in New Jersey, told CNN the study provides new insight in how activity interacts with sedentary behavior as well as sleep.

“Understanding the interaction of sleep and various physical activities is often not examined,” said Malin, who was not involved in the new study.

While the study had some limitations, including a lack of knowledge about the health of the participants, the findings illustrate how “the accumulation of movement patterns in a day to a week to a month is just as, if not more important, than just getting outside for a single session of exercise,” he said.

There was bad news as well: Spending more time sleeping, sitting or engaged only in mild movement was linked to a negative impact on the brain. The study found cognition declined 1% to 2% after replacing an equivalent portion of moderate to vigorous physical activity with eight minutes of sedentary behavior, six minutes of light intensity or seven minutes of sleep.

“In most cases we showed that as little as 7 to 10 minutes less MVPA (moderate to vigorous physical activity) was detrimental,” Mitchell said.

That change is only an association, not a cause and effect, due to the observational methods of the study, Mitchell stressed.

In addition, the study’s findings on sleep can’t be taken at face value, he said. Good quality sleep is critical for the brain to operate at peak performance.

“The evidence on the importance of sleep for cognitive performance is strong,” Mitchell said, “yet there are two major caveats. First, over-sleeping can be linked to poorer cognitive performance.

“Secondly, sleep quality may be even more important than duration. Our accelerometer devices can estimate how long people slept for, but cannot tell us how well they slept.”

Additional studies need to be done to verify these findings and understand the role of each type of activity. However, Mitchell said, the study “highlights how even very modest differences in people’s daily movement — less than 10 minutes — is linked to quite real changes in our cognitive health.”

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Health

A few minutes of brisk activity can help your brain, study finds

Leave a comment

Editor’s Note: Seek advice from a health care provider before starting a workout program.



CNN
 — 

What if you could look at all the things you do daily — walking from room to room, preparing a presentation at your desk, running up and down stairs to deliver folded laundry or taking a jog around the block — and know which ones will best help or hurt your brain?

A new study attempted to answer that question by strapping activity monitors to the thighs of nearly 4,500 people in the United Kingdom and tracking their 24-hour movements for seven days. Researchers then examined how participants’ behavior affected their short-term memory, problem-solving and processing skills.

Here’s the good news: People who spent “even small amounts of time in more vigorous activities — as little as 6 to 9 minutes — compared to sitting, sleeping or gentle activities had higher cognition scores,” said study author John Mitchell, a Medical Research Council doctoral training student at the Institute of Sport, Exercise and Health at University College London, in an email.

Moderate physical activity is typically defined as brisk walking or bicycling or running up and down stairs. Vigorous movement, such as aerobic dancing, jogging, running, swimming and biking up a hill, will boost your heart rate and breathing.

The study, published Monday in the Journal of Epidemiology & Community Health, found doing just under 10 minutes of moderate to vigorous exertion each day improved study participants’ working memory but had its biggest impact on executive processes such as planning and organization.

The cognitive improvement was modest, but as additional time was spent doing the more energetic workout the benefits grew, Mitchell said.

“Given we don’t monitor participants’ cognition over many years, this may be simply that those individuals who move more tend to have higher cognition on average,” he said. “However, yes, it could also imply that even minimal changes to our daily lives can have downstream consequences for our cognition.”

Steven Malin, an associate professor in the department of kinesiology and health at Rutgers University in New Jersey, told CNN the study provides new insight in how activity interacts with sedentary behavior as well as sleep.

“Understanding the interaction of sleep and various physical activities is often not examined,” said Malin, who was not involved in the new study.

While the study had some limitations, including a lack of knowledge about the health of the participants, the findings illustrate how “the accumulation of movement patterns in a day to a week to a month is just as, if not more important, than just getting outside for a single session of exercise,” he said.

There was bad news as well: Spending more time sleeping, sitting or engaged only in mild movement was linked to a negative impact on the brain. The study found cognition declined 1% to 2% after replacing an equivalent portion of moderate to vigorous physical activity with eight minutes of sedentary behavior, six minutes of light intensity or seven minutes of sleep.

“In most cases we showed that as little as 7 to 10 minutes less MVPA (moderate to vigorous physical activity) was detrimental,” Mitchell said.

That change is only an association, not a cause and effect, due to the observational methods of the study, Mitchell stressed.

In addition, the study’s findings on sleep can’t be taken at face value, he said. Good quality sleep is critical for the brain to operate at peak performance.

“The evidence on the importance of sleep for cognitive performance is strong,” Mitchell said, “yet there are two major caveats. First, over-sleeping can be linked to poorer cognitive performance.

“Secondly, sleep quality may be even more important than duration. Our accelerometer devices can estimate how long people slept for, but cannot tell us how well they slept.”

Additional studies need to be done to verify these findings and understand the role of each type of activity. However, Mitchell said, the study “highlights how even very modest differences in people’s daily movement — less than 10 minutes — is linked to quite real changes in our cognitive health.”

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US

Des Moines shooting: 3 people injured at school, police say

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CNN
 — 

Three people were injured Monday in a shooting at a school in Des Moines, Iowa, according to tweets from the Des Moines Police Department.

Police say two of those injured are in critical condition and one was seriously injured.

CNN affiliate KCCI reported that the injured included two students and one staff member.

At 12:53 p.m., Police and fire personnel responded to a report of a shooting at 455 SW 5th Street, which houses Starts Right Here, a charter school, police said in a news release. They found the injured people, who were taken to hospitals.

Starts Right Here is a charter school which helps young people living in disadvantaged circumstances, KCCI reported.

“Approximately twenty minutes after the shooting incident, and two miles away, Des Moines Police Department patrol officers and detectives took multiple suspects into custody following a traffic stop,” the release read.

Police did not identify the suspects or say if they had been charged.



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Health

Many women underestimate breast density as a risk factor for breast cancer, study shows

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CNN
 — 

Dense breast tissue has been associated with up to a four times higher risk of breast cancer. However, a new study suggests few women view breast density as a significant risk factor.

The study, published in JAMA Network Open, surveyed 1,858 women ages 40 to 76 years from 2019 to 2020 who reported having recently undergone mammography, had no history of breast cancer and had heard of breast density.

Women were asked to compare the risk of breast density to five other breast cancer risk factors: having a first-degree relative with breast cancer, being overweight or obese, drinking more than one alcoholic beverage per day, never having children and having a prior breast biopsy.

“When compared to other known and perhaps more well-known breast cancer risks, women did not perceive breast density as significant of a risk,” said Laura Beidler, an author of the study and researcher at the Dartmouth Institute for Health Policy and Clinical Practice.

For example, the authors report that dense breast tissue is associated with a 1.2 to four times higher risk of breast cancer compared with a two times higher risk associated with having a first-degree relative with breast cancer – but 93% of women said breast density was a lesser risk.

Dense breasts tissue refers to breasts that are composed of more glandular and fibrous tissue than fatty tissue. It is a normal and common finding present in about half of women undergoing mammograms.

The researchers also interviewed 61 participants who reported being notified of their breast density and asked what they thought contributes to breast cancer and how they could reduce their risk. While most women correctly noted that breast density could mask tumors on mammograms, few women felt that breast density could be a risk factor for breast cancer.

Roughly one-third of women thought there was nothing they could do to reduce their breast cancer risk, although there are several ways to reduce risk, including maintaining a healthy, active lifestyle and minimizing alcohol consumption.

Breast density changes over a woman’s lifetime, and is generally higher in women who are younger, have a lower body weight, are pregnant or breastfeeding, or are taking hormone replacement therapy.

The level of breast cancer risk increases with the degree of breast density; however, experts aren’t certain why this is true.

“One hypothesis has been that women who have more dense breast tissue also have higher, greater levels of estrogen, circulating estrogen, which contributes to both the breast density and to the risk of developing breast cancer,” said Dr. Harold Burstein, a breast oncologist at the Dana-Farber Cancer Institute who was not involved in the study. “Another hypothesis is that there’s something about the tissue itself, making it more dense, that somehow predisposes to the development of breast cancer. We don’t really know which one explains the observation.”

Thirty-eight states currently mandate that women receive written notification about their breast density and its potential breast cancer risk following mammography; however, studies have shown that many women find this information confusing.

“Even though women are notified usually in writing when they get a report after a mammogram that says, ‘You have increased breast density,’ it’s kind of just tucked in there at the bottom of the report. I’m not sure that anyone is explaining to them, certainly in person or verbally, what that means,” said Dr. Ruth Oratz, a breast oncologist at NYU Langone’s Perlmutter Cancer Center who was not involved in the study.

“I think what we’ve learned from this study is that we have to do a better job of educating not only the general public of women, but the general public of health care providers who are doing the primary care, who are ordering those screening mammograms,” she added.

Current screening guidelines recommend women of average risk of breast cancer undergo breast cancer screening every one to two years between ages 50 to 74 with the option of beginning at age 40.

Because women with dense breast tissue are considered to have higher than average cancer risks, the authors of the study suggest women with high breast density may benefit from supplemental screening like breast MRI or breast ultrasound, which may detect cancers that are missed on mammograms. Currently, coverage of supplemental screening after the initial mammogram varies, depending on the state and insurance policy.

The authors warn that “supplemental screening not only can lead to increased rates of cancer detection but also may result in more false-positive results and recall appointments.” They say clinicians should use risk assessment tools when discussing tradeoffs associated with supplemental screening.

“Usually, it’s a discussion between the patient, the clinical team, and the radiologist. And it’ll be affected by prior history, by whether there’s anything else of concern on the mammogram, by the patient’s family history. So those are the kinds of things we discuss frequently with patients who are in such situations,” Burstein said.

Breast cancer screening recommendations differ between medical organizations, and experts say women at higher risk due to breast density should discuss with their doctor what screening method and frequency are most appropriate.

“I think it’s really, really important that everyone understands – and this is the doctors, the nurses, the women themselves – that screening is not a one size fits all recommendation. We cannot just make one general recommendation to the entire population because individual women have different levels of risks of developing breast cancer,” Oratz said.

For the nearly one-third of women with dense breast tissue that reported there was nothing they could do to prevent breast cancer, experts say there are some steps you can take to reduce your risk.

“Maintaining an active, healthy lifestyle and minimizing alcohol consumption address several modifiable factors. Breastfeeding can decrease the risk. On the other hand, use of hormone replacement therapy increases breast cancer risk,” said Dr. Puneet Singh, a breast surgical oncologist at the MD Anderson Cancer Center who was not involved in the study.

The researchers add that there are approved medications, such as tamoxifen, that can be given for those at significantly increased risk that may reduce the chances of breast cancer by about half.

Finally, breast cancer doctors say that in addition to appropriate screening, knowing your risk factors and advocating for yourself can be powerful tools in preventing and detecting breast cancer.

“At any age, if any woman feels uncomfortable about something that’s going on in her breast, if she has discomfort, notices a change in the breast, bring that to the attention of your doctor and make sure it gets evaluated and don’t let somebody just brush you off,” Oratz said.

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Business

FDA wants to simplify the use and updating of Covid-19 vaccines

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CNN
 — 

The US Food and Drug Administration wants to simplify the Covid-19 vaccine process to look more like what happens with the flu vaccine, according to documents posted online on Monday. That could include streamlining the vaccine composition, immunization schedules and periodic updates of Covid-19 vaccines.

The FDA said it expects to assess circulating strains of the virus that causes Covid-19 at least annually and decide in June which strains to select for the fall season, much like the process to update annual flu vaccines.

Moving forward, the agency said, most people may need only one dose of the latest Covid-19 shot to restore protection, regardless of how many shots they have already received. Two doses may be needed for people who are very young and haven’t been exposed, or for the elderly or immune-compromised, according to the FDA’s briefing document for its vaccine advisers.

The agency is urging a shift toward only one vaccine composition, rather than a combination of monovalent vaccines, which are currently used for primary shots and target only one strain, and bivalent vaccines, which are currently used for booster doses and target more than one strain.

“This simplification of vaccine composition should reduce complexity, decrease vaccine administration errors due to the complexity of the number of different vial presentations, and potentially increase vaccine compliance by allowing clearer communication,” the FDA said.

The FDA’s plan was first reported by National Public Radio.

The agency’s independent vaccine advisers, the Vaccines and Related Biological Products Advisory Committee, are scheduled to meet on Thursday to discuss the future of Covid-19 vaccine regimens, and will be asked to vote on whether they recommend parts of FDA’s plan.

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US

Jeff Zients to replace Ron Klain as White House chief of staff

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CNN
 — 

Jeff Zients, who ran President Joe Biden’s Covid-19 response effort and served in high-ranking roles in the Obama administration, is expected to replace Ron Klain as the next White House chief of staff, according to three people briefed on the matter.

Klain is expected to step down in the coming weeks.

The move to replace Klain is particularly important for Biden, who has entered a critical moment in his presidency and his political future. As he continues to weigh whether to seek reelection in 2024, the early stages of a special counsel investigation into his handling of classified documents has rattled Democrats and emboldened congressional Republicans, who now hold the House majority and have pledged their own probes.

Biden decided on Zients after an internal search when it became clear that Klain favored Zients as his successor, a factor that played a big role in the president’s decision. Klain had tapped Zients to lead a talent search for expected staff turnover following the midterm elections, but that didn’t ultimately materialize after Democrats performed better than expected. Klain is now the most significant departure and is being replaced by the person he picked to help bring in new team members.

A source said Klain will continue to be involved and remain close to the West Wing. Biden’s core political and legislative team – which includes Steve Ricchetti, Anita Dunn, Mike Donilon, Jen O’Malley Dillon, Bruce Reed and Louisa Terrell – will continue to advise him. Zients’ new role is being compared to when Jack Lew was Obama’s chief of staff and others, like David Plouffe, focused more on his political portfolio.

Additional political talent is expected to join for the likely re-election campaign, CNN is told.

In replacing Klain with Zients, Biden is turning to a consultant with more business experience than political background as he enters the third year of his presidency.

The decision to pick Zients surprised some internally given that there were differences in Biden’s and Zients’ management styles early on in the administration. But Biden was impressed with his job as the coronavirus response coordinator when Zients inherited what officials described as a “largely dysfunctional” effort by the Trump administration.

Another factor in the search was how this stretch of Biden’s presidency will focus on implementing the legislation enacted in his first two years, and Zients is seen internally as a “master implementor,” one source said. His operational skills were on display as his handled the coronavirus response and helped with the bungled 2013 launch of HealthCare.gov during the Obama administration.

Zients now has a closer relationship with Biden and with his senior advisers and multiple Cabinet members.

While Zients is not viewed as a political operator, his deep experience inside two administrations and his reputation for technocratic skill would likely serve as assets at a time when both are viewed as critical for what Biden faces in the year ahead. Still, he will be tasked with replacing an official who was a central force inside the administration – and someone with a rapport developed over decades with Biden himself.

Klain, who had long planned to depart the White House after Biden’s first two years, has targeted the weeks after the February 7 State of the Union address for the end of his tenure.

A number of top officials had been viewed as top candidates to succeed Klain, including Cabinet members and close Biden advisers such as Ricchetti, counselor to the president, and Dunn, the senior adviser with a wide-ranging strategy and communications portfolio.

But while Zients isn’t among the tight-knit circle of long-tenured Biden advisers, he’s been deeply intertwined with the team since the 2020 campaign, when he served as co-chairman of Biden’s transition outfit.

After the election Biden tapped Zients to lead the administration’s Covid-19 response effort as he entered office with the country facing dueling public health and economic crises. While Zients left that role last spring, he was once again brought into White House operations a few months later when Klain asked him to lead the planning for the expected turnover inside the administration that historically follows a president’s first midterm elections.

Zients was tasked with conducting a wide and diverse search for prospective candidates outside the administration to fill Cabinet, deputy Cabinet and senior administration roles, officials said, in an effort that would be closely coordinated with White House counterparts.

But even as wide-scale turnover has remained minimal for an administration that has taken pride in its stability in the first two years, now, the official leading the planning effort may soon shift into one of, if not the, most critical role set to open.

The White House chief of staff is a grueling and all-consuming post in any administration, and Klain’s deep involvement across nearly every key element of process, policy and politics touching the West Wing only served to elevate that reality.

A long-time Washington hand with ties Democratic administrations – and Biden – that cross several decades, Klain is departing at a moment that officials inside the West Wing have spent the last several months viewing as a high point.

Biden entered 2023 on the heel of midterm elections that resulted in an expanded Senate majority for his Democratic Party and the defiance of widespread expectations of massive GOP victories in the House.

The sweeping and far-reaching cornerstones of Biden’s legislative agenda have largely been signed into law, the result of a series of major bipartisan wins paired with the successful navigation of intraparty disputes to secure critical Democratic priorities.

Biden has made clear to advisers that the successful implementation of those laws – which is now starting to kick into high gear across the administration – is one of their most critical priorities for the year ahead.

But Zients will also inherit a West Wing now faced with a new House Republican majority that is girding for partisan warfare – and wide-scale investigations into the administration and Biden’s family.

This story has been updated with additional information.

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Sports

Patrick Mahomes suffers injury scare as Kansas City Chiefs reach AFC championship game

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CNN
 — 

The Kansas City Chiefs defeated the Jacksonville Jaguars 27-20 on Saturday to advance to the AFC championship game but there is now concern over the fitness of Patrick Mahomes.

The Chiefs’ star quarterback was brought down by Jaguars’ Arden Key and Corey Peters in the first quarter and replays showed Mahomes’ ankle getting caught awkwardly under Key as both men fell to the ground.

Mahomes instantly reached for his right ankle and was seen limping to the sidelines to speak to his team’s coaches before hobbling back onto the field.

“Obviously, I have a lot of adrenaline going right now, so we’ll see how it feels,” Mahomes told reporters.

“But I’ll hop right in the treatment tonight and try to do whatever I can to be as close to 100 percent by next week.

“Luckily for us, we played the early game on Saturday, so we get an extra almost half a day that I can let that ankle rest.”

Despite his injury, the 27-year-old stayed in the game for the rest of the first quarter but he was in obvious discomfort.

In the second quarter, with his ankle taped up, Mahomes appeared to get into a heated discussion with head coach Andy Reid and threw his jacket down as he headed to the locker room for evaluation.

Chad Henne took over at quarterback and went on to lead the Chiefs to a touchdown to take a 17-7 lead.

Despite the team listing him as questionable to return, Mahomes came back in the second half and led the team to the victory, ending the night with 195 yards passing and two touchdowns.

“I didn’t want to go get the X-Rays or whatever it was. I just wanted to continue to play,” Mahomes added, explaining his argument with Reid.

“I told them I’d do it at halftime but the coach, in the best interest of me, made me go back there and get that X-Ray before coming back into the game.

“For a while, I thought I could play through it but he said he would not put me back in ‘so might as well go get that X-Ray and if it’s negative or whatever I’ll put you back in.’

“I ran back there, got the X-Ray and was able to play and finish the game.”

The Chiefs have now reached the AFC Championship game for the fifth consecutive year but there are now doubts about Mahomes’ ability to play on January 29.

Their opponent will be either the Cincinnati Bengals or the Buffalo Bills, with both teams set to play later on Sunday.

“He’s a tough kid. He wanted to be in there,” Reid told reporters when asked about Mahomes, not committing to him playing next Sunday.

“He wanted to be competing and that’s a tribute to him and his competitiveness.

“However, you got to make sure he’s okay, physically okay, where he can protect himself and if he can’t then he can’t play.

“You have to go to the next guy. He’s a tough nut and, when I tell you he is competitive, he’s very very competitive.”

Elsewhere, the Philadelphia Eagles defeated the New York Giants 38-7 to advance to the team’s eighth NFC championship game in franchise history and the first since 2018.

The Eagles came out of the gates strong and finished even stronger.

Philadelphia quarterback Jalen Hurts threw for 154 yards and two touchdowns while adding a rushing touchdown as well. Eagles running backs Miles Sanders and Kenneth Gainwell combined to rush for 202 yards.

The Eagles will face either the Dallas Cowboys or the San Francisco 49ers on January 29 for a place in the Super Bowl final on February 12.

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Business

Here are the companies that have laid off employees this year

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New York
CNN
 — 

Just this week, Alphabet, Google’s parent company, Microsoft

(MSFT) and Vox Media announced layoffs that will affect more than 22,000 workers.

Their moves follow on the heels of job cuts earlier this month at Amazon, Goldman Sachs and Salesforce. More companies are expected to do the same as firms that aggressively hired over the last two years slam on the brakes, and in many cases shift into reverse.

The cutbacks are in sharp contrast to 2022, which had the second-highest level of job gains on record, with 4.5 million. But last year’s job numbers began falling as the year went on, with December’s job report showing the lowest monthly gains in two years.

The highest level of hiring occurred in 2021, when 6.7 million jobs were added. But that came on the heels of the first year of the pandemic, when the US effectively shut down and 9.3 million jobs were lost.

The current layoffs are across multiple industries, from media firms to Wall Street, but so far are hitting Big Tech especially hard.

That’s a contrast from job losses during the pandemic, which saw consumers’ buying habits shifting toward e-commerce and other online services during lockdown. Tech firms went on a hiring spree.

But now, workers are returning to their offices and in-person shopping is bouncing back. Add in the increasing likelihood of a recession, higher interest rates and tepid demand due to rising prices, and tech businesses are slashing their costs.

January has been filled with headlines announcing job cuts at company after company. Here is a list of layoffs this month – so far.

Google

(GOOGL)’s parent said Friday it is laying off 12,000 workers across product areas and regions, or 6% of its workforce. Alphabet added 50,000 workers over the past two years as the pandemic created greater demand for its services. But recent recession fears has advertisers pulling back from its core digital ad business.

“Over the past two years we’ve seen periods of dramatic growth,” CEO Sundar Pichai said in an email to employees. “To match and fuel that growth, we hired for a different economic reality than the one we face today.”

The tech behemoth is laying off 10,000 employees, the company said in a securities filing on Wednesday. Globally, Microsoft has 221,000 full-time employees with 122,000 of them based in the US.

CEO Satya Nadella said during a talk at Davos that “no one can defy gravity” and that Microsoft could not ignore the weaker global economy.

“We’re living through times of significant change, and as I meet with customers and partners, a few things are clear,” Nadella wrote in a memo. “First, as we saw customers accelerate their digital spend during the pandemic, we’re now seeing them optimize their digital spend to do more with less.”

The publisher of the news and opinion website Vox, tech website The Verge and New York Magazine, announced Friday that it’s cutting 7% of its staff, or about 130 people.

“We are experiencing and expect more of the same economic and financial pressures that others in the media and tech industries have encountered,” chief executive Jim Bankoff said in a memo.

Layoffs are also hitting Wall Street hard. The world’s largest asset manager is eliminating 500 jobs, or less than 3% of its workforce.

Today’s “unprecedented market environment” is a stark contrast from its attitude over the last three years,, when it increased its staff by about 22%. Its last major round of cutbacks was in 2019.

The bank will lay off up to 3,200 workers this month amid a slump in global dealmaking activity. More than a third of the cuts are expected to be from the firm’s trading and banking units. Goldman Sachs

(FADXX) had almost 50,000 employees at the end of last year’s third quarter.

The crypto brokerage announced in early January that it’s cutting 950 people – almost one in five employees in its workforce. The move comes just a few months after Coinbase laid off 1,100 people.

Though Bitcoin had a solid start to the new year, crypto companies were slammed by significant drops in prices of Bitcoin and other cryptocurrencies.

McDonald’s

(MCD), which thrived during the pandemic, is planning on cutting some of its corporate staff, CEO Chris Kempczinski said this month.

“We will evaluate roles and staffing levels in parts of the organization and there will be difficult discussions and decisions ahead,” Kempszinski said, outlining a plan to “break down internal barriers, grow more innovative and reduce work that doesn’t align with the company’s priorities.”

The online personalized subscription clothing retailer said it plans to lay off 20% of its salaried staff.

“We will be losing many talented team members from across the company and I am truly sorry,” Stitch Fix

(SFIX) founder and former CEO Katrina Lake wrote in a blog post.

As the new year began, Amazon

(AMZN) said it plans to lay off more than 18,000 employees. Departments from human resources to the company’s Amazon

(AMZN) Stores will be affected.

“Companies that last a long time go through different phases. They’re not in heavy people expansion mode every year,” CEO Andy Jassy said in a memo to employees.

Amazon boomed during the pandemic, and hired rapidly over the last few years. But demand has cooled as consumers return to their offline lives and battle high prices. Amazon says it has more than 800,000 employees.

At The New York Times DealBook summit In November, Jassy said he believes Amazon “made the right decision” regarding its rapid infrastructure build out but said its hiring spree is a “lesson for everyone.”

Even as he spoke, Amazon warehouse workers who helped organize the company’s first-ever US labor union at a Staten Island facility last year were picketing Jassy’s appearance outside the conference venue.

“We definitely want to take this opportunity to let him know that the workers are waiting and we are ready to negotiate our first contract,” Amazon Labor Union President Chris Smalls said, calling the protest a “welcoming party” for Jassy.

Salesforce

(CRM) will cut about 10% of its workforce from its more than 70,000 employess and reduce its real estate footprint. In a letter to employees, Salesforce

(CRM)’s chair and co-CEO Marc Benioff admitted to adding too much to the company’s headcount early in the pandemic.

– CNN’s Clare Duffy, Matt Egan, Oliver Darcy, Julia Horowitz, Catherine Thorbecke, Paul R. La Monica, Nathaniel Meyersohn, Parija Kavilanz, Danielle Wiener-Bronner and Hanna Ziady contributed to this report.

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US

A Florida woman is barricading herself inside a Daytona Beach hospital room after shooting her terminally ill husband

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CNN
 — 

A woman has confined herself to a room inside a Daytona Beach, Florida, hospital after shooting her terminally ill husband on Saturday, police say.

Officers arrived at the Advent Health Hospital after receiving a report of about a person being shot, Daytona Beach police said in a release obtained by CNN affiliate WESH.

“Officers have evacuated staff and patients around the room, and at this time the female is not seen as a threat to staff or patients. No one else has been injured,” the release said. “We are currently negotiating with the female to get her to surrender and come out of the hospital.”

Dr. Joshua Horenstein, a cardiologist at Advent Health Hospital, was working in the emergency department when he learned of the shooting incident.

“Someone came in screaming in the emergency department that this was not a drill and to shelter in place,” Horenstein told CNN while hiding in a supply room with a nurse.

Horenstein said he was finally able to leave the supply room after roughly 90 minutes.

Daytona Beach Police are expected to hold a press conference Saturday afternoon, according to a tweet on the department’s verified Twitter account.

Police are asking people to stay away from the area.

CNN has reached out to hospital staff, some who are currently on lockdown inside the hospital.

The status of the woman’s husband is unclear at this time.

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