Tag Archives: hint

‘Quiet on Set’ Directors Hint at Social Media as Next Area of Child Entertainment to Investigate – Hollywood Reporter

  1. ‘Quiet on Set’ Directors Hint at Social Media as Next Area of Child Entertainment to Investigate Hollywood Reporter
  2. ‘All That’ Cast Members Say Dan Schneider Reached Out for a ‘Quote of Support’ Ahead of Doc, Criticize His ‘Performance’ of an Apology Video Variety
  3. ‘Quiet on Set’ directors are ‘committed to continuing the investigation’ into allegations of toxic culture at Nickelodeon Yahoo Entertainment
  4. ‘Blue’s Clues’ star Steve Burns says ‘Quiet on Set’ is ‘heartbreaking’ Entertainment Weekly News
  5. What ‘Quiet on Set’ Leaves Out Is Just As Damning Vulture

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Jeremy Renner appears to hint at his return to acting by reposting a photo from his Mayor Of Kingstown co-star – Daily Mail

  1. Jeremy Renner appears to hint at his return to acting by reposting a photo from his Mayor Of Kingstown co-star Daily Mail
  2. Jeremy Renner back filming ‘Mayor of Kingstown’ after snowplow accident Entertainment Weekly News
  3. One Year After Jeremy Renner’s Snow Plow Accident, He Shared Sweet Update About Getting Back To Work On Mayor Of Kingstown Yahoo Entertainment
  4. Jeremy Renner visits Renown hospital in Reno a year after near-fatal accident Reno Gazette Journal
  5. ‘Mayor Of Kingstown’ Stars Jeremy Renner & Emma Laird Tease Return To Production For Season 3 Of Paramount+ Crime Drama Deadline

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Jon Gruden’s quest for retribution vs. NFL looks ironclad and shows no hint of a settlement – Yahoo Sports

  1. Jon Gruden’s quest for retribution vs. NFL looks ironclad and shows no hint of a settlement Yahoo Sports
  2. PFT’s Mike Florio: How Gruden-Snyder Controversy Could Crater Commanders Sale | The Rich Eisen Show The Rich Eisen Show
  3. Commanders sale: Serious legal issues related to Jon Gruden lawsuit ‘threaten to complicate’ deal, per report CBS Sports
  4. Raiders News: 6 takeaways from new article on Jon Gruden’s email scandal Silver And Black Pride
  5. Dan Snyder reportedly used “Blackmail PowerPoint” to lessen initial NFL punishment NBC Sports
  6. View Full Coverage on Google News

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The ‘Tripledemic’ Holiday: How to Fly More Safely (Hint: Wear a Mask)

A third year of pandemic holiday travel is upon us, but this year instead of just thinking about how to stay safe from the coronavirus, people are also worrying about how to avoid the flu and respiratory syncytial virus, or RSV, the so-called tripledemic.

What’s also different this year is that there is no federal mandate to wear masks on public transportation. And even though cases of the coronavirus have been ticking up, there is no suggestion that mandates will be reinstated.

The Centers for Disease Control and Prevention and the Transportation Security Administration suggest that it’s a good idea to mask up, but are not requiring travelers to do so.

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“CDC recommends properly wearing a high-quality mask or respirator over the nose and mouth in indoor areas of public transportation (such as airplanes, trains, buses, ferries) and transportation hubs (such as airports, stations and seaports),” the CDC says on its website.

With the number of people flying tracking close to 2019 levels — the TSA screened more than 4.5 million people over the past weekend — here are some steps you can take to stay safer as you travel during the holidays.

Should I wear a mask on the plane, even though it’s not required?

You should “absolutely” be wearing masks while traveling, public health researchers, infectious disease doctors and air-filtration experts said. Even though planes have great filtration systems, you’ll likely be on crowded planes with other travelers for extended periods of time, increasing the chances of exposure, said Saskia Popescu, an infectious disease public health researcher and assistant professor at the Schar School of Policy and Government at George Mason University.

“Now compound this with rapidly rising numbers of COVID, influenza, RSV and seasonal respiratory viruses,” she said. “I would highly recommend if you’re traveling in a plane, train, bus or boat, you wear a mask.”

Do I need to keep a mask on elsewhere?

Dr. Linsey Marr, a professor of civil and environmental engineering at Virginia Tech and an expert on airborne transmission of viruses said: “If you have a vacation coming up, and it’s really important to you that you want to be well and you want to be able to spend time with your loved ones or do some activity that you’ve been looking forward to all year, and you don’t want to be laid up in bed sick or potentially getting other people sick, then definitely wear a mask when you’re traveling.” She added: “Not just on the plane, but in the airports, on buses, transit and everywhere else that you’re going in between.”

Even if you’re not traveling, experts say that while it’s no longer required, it’s a good idea to mask up anywhere you will be around a lot of people in a confined space.

Popescu said she recently began to develop nonspecific symptoms, including a sore throat. It turned out that she had COVID and she had caught it while flying home from a work trip.

“I can personally say that it’s those moments you perceive as lower risk or let your guard down that can result in exposure,” she said.

I know masking avoids spreading the coronavirus, but what about the flu and RSV?

Masking prevents the spread of all kinds of germs and is “the best tool we have to prevent the spread of those surging respiratory viruses, from COVID to influenza to RSV,” Popescu said.

Marr said that the flu and RSV transmit “at least partly” in the same way as COVID-19.

Traveling over the holidays is a good time to remember the “three C’s” we first started hearing about in 2020 — closed spaces with poor ventilation, crowded places and close-contact situations — and to wear a mask in each of these situations.

Should I wear a specific kind of mask when traveling?

Even though wearing a mask is most effective at stopping the spread of a virus when the infected person is wearing it, masking to protect yourself from disease is still beneficial, especially if you’re using a high-quality mask.

“If you’re going to bother wearing a mask at this point, I think you should get a high-quality one,” said Marr. That generally means an N95, KN95 or KF94, she added. “Those are going to be much more effective than a cloth mask or surgical mask.”

These are widely available, affordable and you can wear the same one until you notice that it’s dirty, the straps are getting loose or if it is damaged.

Do I have to take a COVID test before and after I travel?

If you’re traveling within the U.S. or to the U.S. from abroad, you’re not required to take a test, but the CDC and medical authorities say it’s a good idea. “Consider getting tested with a viral test as close to the time of departure as possible (no more than three days) before travel,” the CDC says. If you test positive, they say, you should delay your travel.

If you’re traveling and plan to interact with people without a mask, even more reason to test before your flight and for a few days after you land,” Popescu said. “How much you test is really about your risk profile and preference.”

You should consider things like how much you’re interacting with others, whether you’ll be with vulnerable people and if you’ll be unmasked.

“Overall, I recommend testing before you leave and a couple of times during your trip,” Popescu said.

What about being vaccinated?

U.S. citizens and immigrants do not need to be vaccinated to fly within the U.S. or to the U.S. from abroad. Non-U.S. citizens and non-U.S. immigrants traveling to the U.S. by air are required to show proof of being fully vaccinated against COVID-19. Only limited exceptions apply. If you are not fully vaccinated and are allowed to travel to the United States by air through an exception, you will be required to sign an attestation before you board your flight stating you meet the exception. Depending on the type of exception, you may also have to state you have arranged to take certain protective measures.

Also, all travelers have to give their contact information to airlines to help with contact tracing, if necessary.

Is it too late to get a booster?

Bernard Camins, the medical director for infection prevention at the Mount Sinai Health System, and Aaron Milstone, a pediatric infectious diseases specialist at Johns Hopkins Children’s Center, both said that it is “never too late” to get an updated COVID booster.

“Most data suggest that a full immune response to a vaccine dose can take 14 days, but some of our early data showed that people can generate an antibody response in a few days,” said Milstone. “You might be more protected in a few weeks, but there can be some benefit as soon as a few days after, so get an early holiday present by getting the boost.”

Camins said that because there isn’t great data on this aspect of boosters, it’s possible that the booster could reach efficacy before the 14-day mark. And, he said, with vaccines in plentiful supply it’s easy to get jabbed quickly. “If you make an appointment today it would work,” he said.

Is there anything else I can do to prepare safely for my trip?

The experts suggest thinking about why you’re traveling and perhaps taking extra precautions. “We’re at the point where for most people these diseases are not a personal threat if you’re healthy. At the same time, at the holidays we’re often gathering with family, and visiting with more vulnerable people and older family members in particular,” said Marr.

Marr’s nuclear family will be spending the holidays with her elderly parents, so in an effort to minimize the chances of spreading any illness to them, her family unit will be taking more precautions, like not visiting crowded indoor spaces before their trip.

“We probably won’t go out to any restaurants in that week leading up to it just to make sure to minimize our chances of picking up a virus and bringing it to them,” she said.

The flu and seasonal respiratory viruses like RSV are also spread more easily through contaminated items and hands, “so hand hygiene and cleaning/disinfection of high-touch surfaces is an important strategy,” Popescu said. “Also, a good reminder to avoid touching your face.”

© 2022 The New York Times Company

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Galaxy S23 Ultra benchmark results hint at tremendous performance uplift

The Samsung Galaxy S23 family will allegedly be powered by the Qualcomm Snapdragon 8 Gen 2 chip in all markets and a few days back, the standard Galaxy S23 appeared on Geekbench with an impressive score, and now, the Galaxy S23 Ultra has also been spotted on the benchmarking site.

Contrary to what some reports had suggested, Qualcomm’s next high-end chip will stick to a tri-cluster arrangement but that doesn’t mean that the rumors were totally false as the chip maker appears to have tweaked its approach.

Instead of going for one high-speed core, three middle cores, and four low-power cores, Qualcomm has opted for one high-power application core running at 3.36Ghz, four mid-range cores operating at 2.80GHz, and three small cores with speeds of 2.02Ghz.

This arrangement has apparently made a world of difference, at least as far as benchmark scores are confirmed, which don’t necessarily reflect day-to-day performance.

MySmartPrice saw the US-bound model of the Galaxy S23 Ultra with the model number SM-S918U on Geekbench. It got 1,521 points on the single-core test and a score of 4,689 on the multi-core test. For comparison, the S22 Ultra got 1,157 and 3,307 points on the same test.

Needless to say, performance appears to have gone up significantly and since this was probably a non-final version and there are more software optimizations to be done, the retail version should score even better.

The model that was tested had 8GB of RAM but Samsung will most likely sell a 12GB version too. The phone’s performance will presumably be further boosted by the new LPDDR5X DRAM tech that Samsung announced a few days back.
With great performance comes great concern about overheating, but since the Snapdragon 8 Gen 2 will probably be manufactured by TSMC and not Samsung, this shouldn’t be a problem.
The Galaxy S23 Ultra is sounding like a promising phone that will easily outshine the best phones of 2022. It’s expected to have an insane 200MP camera and a more refined design than the outgoing model. Its predecessor’s 6.8-inch display and 5,000mAh battery will be retained. Samsung is expected to announce the device early next year.

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Old Cancer Drugs Hint at New Ways to Beat Chronic Pain

Summary: Repurposing drugs used in the treatment of lung cancer could offer hope for symptom relief for patients suffering from chronic pain.

Source: IMBA

Pain is an important alarm system that alerts us to tissue damage and prompts us to withdraw from harmful situations. Pain is expected to subside as injuries heal, but many patients experience persistent pain long after recovery.

Now, a new study published in Science Translational Medicine points to possible new treatments for chronic pain with a surprising link to lung cancer.

The work was spearheaded by an international team of researchers at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Harvard Medical School, and Boston Children’s Hospital.

Their findings of the research, conducted in laboratory mouse models, open up multiple therapeutic opportunities that could allow the world to improve chronic pain management and eclipse the opioid epidemic.

Acute pain is an important danger signal. By contrast, chronic pain is based on persistent injury and can even be experienced in the absence of a stimulus, injury, or disease. Despite the hundreds of millions of people affected, chronic pain is among the least well-managed areas of healthcare.

To improve how persistent pain is managed and considering the raging opioid crisis, it is paramount to develop novel drugs based on a fundamental understanding of the underlying mechanisms.

“We had previously shown that sensory neurons produce a specific metabolite, BH4, which then drives chronic pain, such as neuropathic pain or inflammatory pain,” says project lead and co-corresponding author Shane Cronin, a staff scientist in the Penninger lab at IMBA and a former postdoc in the Woolf lab at Harvard Medical School and F.M. Kirby Neurobiology Center, Boston Children’s Hospital.

“The concentrations of BH4 correlated very well with the pain intensity. So, we naturally thought that this was a great pathway to target.”

To identify drugs that reduce BH4 levels in pain neurons, the researchers performed a “phenotypic screen” of 1000 target-annotated, FDA-approved medications. This approach allowed the scientists to start their search using medications that are currently in use for various indications, and to identify undescribed, off-target analgesic properties.

Among the first findings of this hypothesis-driven search, the team was able to link the previously observed analgesic effects of several drugs, including clonidine and capsaicin, to the BH4 pathway.

“However, our phenotypic screen also allowed us to ‘repurpose’ a surprising drug,” says Cronin. The drug ‘fluphenazine’, an antipsychotic, has been used to treat schizophrenia. “We found that fluphenazine blocks the BH4 pathway in injured nerves. We also demonstrated its effects in chronic pain following nerve injury in vivo.

The researchers also found that the effective analgesic dose of fluphenazine in their experiments in the mouse model is comparable to the low end of the doses safely indicated for schizophrenia in humans.

In addition, the screen uncovered a novel and unexpected molecular link between the BH4 pathway and EGFR/KRAS signaling, a pathway involved in multiple cancers. Blocking EGFR/KRAS signaling reduced pain sensitivity by decreasing the levels of BH4.

The genes of EGFR and KRAS are the two most frequently mutated genes in lung cancer, which prompted the researchers to look at BH4 in lung cancer.

Surprisingly, by deleting an important enzyme, GCH1, in the BH4 pathway, the mouse models of KRAS-driven lung cancer developed fewer tumors and survived much longer. Hence, the researchers uncovered a common signaling pathway for chronic pain and lung cancer through EGFR/KRAS and BH4, thus opening up new avenues of treatment for both conditions.

Mouse sensory neurons are shown in magenta. BH4, the molecule driving chronic pain, is shown in green. Hence, the neurons “in pain” are seen in green/white. Credit: Cronin/IMBA

“Chronic pain is currently subjected to often ineffective palliative treatments. Furthermore, effective painkillers such as opioids can lead, if used inappropriately, to severe addiction. It is therefore critical to find and develop new and repurposed drugs to treat chronic pain,” says co-corresponding author Clifford Woolf, professor of neurology and neurobiology at Harvard Medical School and director of the F.M. Kirby Neurobiology Center at Boston Children’s Hospital.

One intriguing aspect of the study is the mechanistic link between pain and lung cancer.

“The same triggers that drive tumor growth appear to be also involved in setting the path to chronic pain, often experienced by cancer patients. We also know that sensory nerves can drive cancer, which could explain the vicious circuit of cancer and pain,” adds co-corresponding author Josef Penninger, IMBA group leader and founding director, who is currently also the director of the Life Sciences Institute at the University of British Columbia (UBC), Vancouver, Canada.

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“Understanding these cross-talks is therefore not only critical for cancer treatments but might also help to improve the quality of life for cancer patients towards less pain.”

About this pain and neuropharmacology research news

Author: Daniel F. Azar
Source: IMBA
Contact: Daniel F. Azar – IMBA
Image: The image is credited to Cronin/IMBA

Original Research: Closed access.
“Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer” by Cronin, S. J. F et al. Science Translational Medicine


Abstract

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single-nucleotide polymorphism studies, together with mouse genetic modeling, have demonstrated that decreased GCH1 leads to both reduced BH4 and pain.

However, little is known about the regulation of Gch1 expression upon nerve injury and whether this could be modulated as an analgesic therapeutic intervention.

We performed a phenotypic screen using about 1000 bioactive compounds, many of which are target-annotated FDA-approved drugs, for their effect on regulating Gch1 expression in rodent injured dorsal root ganglion neurons. From this approach, we uncovered relevant pathways that regulate Gch1 expression in sensory neurons.

We report that EGFR/KRAS signaling triggers increased Gch1 expression and contributes to neuropathic pain; conversely, inhibiting EGFR suppressed GCH1 and BH4 and exerted analgesic effects, suggesting a molecular link between EGFR/KRAS and pain perception. We also show that GCH1/BH4 acts downstream of KRAS to drive lung cancer, identifying a potentially druggable pathway.

Our screen shows that pharmacologic modulation of GCH1 expression and BH4 could be used to develop pharmacological treatments to alleviate pain and identified a critical role for EGFR-regulated GCH1/BH4 expression in neuropathic pain and cancer in rodents.

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Galaxy S23 Ultra: Samsung confirms 200 MP camera and brings in Qualcomm 3D Sonic Max as further rumors hint at paradigm-shifting smartphone

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FBI Records Hint Why Brad Pitt Never Charged in Alleged Jet Assault

Dramatic new details about the mid-air meltdown that ended Brad Pitt’s marriage to Angelina Jolie – but did not lead to criminal charges – are coming to light in newly surfaced FBI investigative records obtained Tuesday by Rolling Stone.

The records include an interview summary in which Jolie purportedly told FBI officials that Pitt yelled at her, “grabbed her by her head,” shook her, “pushed her into the bathroom wall” and repeatedly punched the ceiling of the plane during an initial outburst about 90 minutes into the private jet flight that departed France and made a pitstop in Minnesota before eventually landing in Los Angeles on Sept. 14, 2016.

Jolie said Pitt’s actions frightened the couple’s six children, who ranged in age from 8 to 15 at the time. When one of the kids allegedly called Pitt a “prick,” he bolted at the minor “like he was going to attack,” the paperwork states. At that point, Jolie “jumped up” and grabbed Pitt round his neck with her arms, “like in a choke hold,” according to the report summarizing Jolie’s version of events. Pitt purportedly threw himself back, pushing Jolie into the seats behind them, causing injury to her back and elbow, she told investigators.

According to the highly redacted paperwork, Pitt allegedly consumed multiple alcoholic beverages during the flight and at one point “poured beer on (Jolie) and the blanket she was under.” When the plane landed, it also had $25,000 worth of damage from spilled red wine, Jolie claimed.

Jolie said Pitt’s alleged behavior “didn’t feel real” and left her feeling “scared” and “like a hostage.” She claimed Pitt pushed her again when she suggested taking the couple’s children to a hotel to get some much-needed sleep after landing. “You’re not taking my fucking kids,” Pitt allegedly yelled in response.

Jolie detailed her injuries to FBI investigators, including a “rug-burn type wound on her right hand.” When asked about a “scratch” on Pitt, she replied that it could have been from her, the paperwork states.

The fact that both parties had apparent injuries likely complicated the charging decision for investigators. The files obtained by Rolling Stone also said that Jolie “was personally conflicted on whether or not to be supportive of charges.” At least, that’s what her lawyer expressed in a call with investigators in December 2016, weeks after prosecutors made their initial decision to decline charges.

“After reviewing the document, representative(s) of the United States Attorney’s Office discussed the merits of this investigation with the case agent. It was agreed by all parties that criminal charges in this case would not be pursued due to several factors,” the FBI case agent wrote in a report memorializing a Nov. 22, 2016, meeting.

“In response to allegations made following a flight within the special aircraft jurisdiction of the United States which landed in Los Angeles carrying Mr. Brad Pitt and his children, the FBI has conducted a review of the circumstances and will not pursue further investigation,” Laura Eimiller, a spokeswoman for the FBI’s field office in Los Angeles, said in  Nov. 22, 2016 statement. “No charges have been filed in this matter.”

Jolie, 47, filed for divorce within days of the jet confrontation. She and Pitt, 58, were later declared legally single, but their custody arrangement remains in dispute.

The FBI files obtained by Rolling Stone were the results of a FOIA request linked to Jolie’s ongoing pursuit of more documentation in the case. That effort led the Maleficent star to sue the Justice Department as a Jane Doe plaintiff in March. Politico first speculated that Jolie was the anonymous plaintiff behind the suit, and Puck confirmed the hunch Tuesday. Jolie is seeking a more thorough search of government records for non-exempt files related to the 2016 probe.

Reps for Jolie and Pitt did not respond to requests for comment from Rolling Stone.

A source close to Pitt previously told this reporter that the actor engaged in a verbal argument with his oldest son Maddox during the jet ride. “He certainly could have behaved better, but there was no physical abuse (of the teen),” the source said.



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Dollar jumps vs yen as Fed officials hint more rate hikes coming

NEW YORK, Aug 2 (Reuters) – The dollar strengthened sharply against the Japanese yen on Tuesday as remarks by U.S. Federal Reserve officials hinted that more interest rate hikes are coming in the near term.

A trio of Fed officials from across the policy spectrum suggested Tuesday that they and their colleagues remain resolute and united on getting U.S. rates up to a level that will put a dent in activity and inflation. read more

“We got a steady dose of Fed speak that… triggered a strong move back into the greenback,” said Edward Moya, senior market analyst at Oanda in New York.

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“What you’re seeing is that the dollar’s reign is not going to go away any time soon, as the interest rate differential seems like it might get even wider against the yen.”

Investors remain keen to see the U.S. monthly jobs report on Friday.

The U.S. dollar index , which measures the greenback against six peers, was last up 0.9% at 106.31. The index had eased recently as investors began reassessing how aggressive the Fed may be with rate hikes in the future.

Against the yen, the dollar was up 1.2% at 133.12 yen.

The dollar rose to a session higher against the yen as yields in the U.S. Treasury market rallied. U.S. two-year yields, which reflect rate expectations, rose to one-week highs .

Early in the session, the dollar had been weaker against the yen as concern over U.S. House of Representatives Speaker Nancy Pelosi’s visit to Taiwan made investors more risk averse.

Pelosi said her trip demonstrated American solidarity with the Chinese-claimed self-ruled island, but China condemned the highest-level U.S. visit in 25 years as a threat to peace and stability. read more

The offshore Chinese yuan fell 0.09% versus the greenback at $6.7780 per dollar.

The Australian dollar was down 1.5% in the wake of the Reserve Bank of Australia’s move to raise interest rates by 50 bps to 1.85%, in line with expectations. read more

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Currency bid prices at 4:30PM (2030 GMT)

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Reporting by Caroline Valetkevitch;
Additional reporting by Saikat Chatterjee in London; Editing by David Holmes, Susan Fenton and Lisa Shumaker

Our Standards: The Thomson Reuters Trust Principles.

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