Tag Archives: harder

Study shows that smoking ‘stops’ cancer-fighting proteins, causing cancer and making it harder to treat – Medical Xpress

  1. Study shows that smoking ‘stops’ cancer-fighting proteins, causing cancer and making it harder to treat Medical Xpress
  2. Smoking ‘stops’ cancer-fighting proteins, makes harder to treat the disease: Study Gulf News
  3. How tobacco smoking undermines anti-cancer defenses: study Arab Times Kuwait News
  4. Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes Science
  5. Tobacco smoking undermines anti-cancer safeguards by causing harmful DNA mutations News-Medical.Net
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Unlocking the Secrets of COVID-19: Why Some Populations Are Hit Harder Than Others – SciTechDaily

  1. Unlocking the Secrets of COVID-19: Why Some Populations Are Hit Harder Than Others SciTechDaily
  2. SARS-CoV-2: How the history of human populations influences their immune response Phys.org
  3. Post-Covid condition and clinic characteristics associated with SARS-CoV-2 infection: a 2-year follow-up to Brazilian cases | Scientific Reports Nature.com
  4. Antinucleocapsid Antibody Response Can Help Diagnose Postacute Sequelae of SARS-CoV-2, Improve Treatment Access AJMC.com Managed Markets Network
  5. SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice | Proceedings of the National Academy of Sciences pnas.org
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Proskauer Goes Even Harder After Former Firm Executive With Amended Complaint – Above the Law

  1. Proskauer Goes Even Harder After Former Firm Executive With Amended Complaint Above the Law
  2. Proskauer Rose Legal Malpractice Suit Claims Firm Charged ‘Excessive and Unconscionable’ Fees in Trustee Dispute | The Recorder Law.com
  3. Ex-Proskauer COO Accused of Scheme to Poach Staff for Rival Firm Bloomberg Law
  4. Proskauer adds fraud claim, says law firm execs conspired in trade secrets case Reuters
  5. Fired Proskauer Rose COO Also Defrauded Firm, Deleted ‘Hundreds’ of Messages, New Filing Alleges | The American Lawyer Law.com
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Michael B. Jordan admits muscle gain for ‘Creed’ has been harder as he’s gotten older – Yahoo Entertainment

  1. Michael B. Jordan admits muscle gain for ‘Creed’ has been harder as he’s gotten older Yahoo Entertainment
  2. Michael B. Jordan Diet: Workout Plan ‘Creed,’ ‘Black Panther’ Cheat Day STYLECASTER
  3. Michael B. Jordan and Jonathan Majors on ‘Creed III’ The New York Times
  4. How Jonathan Majors prepared to fight Michael B. Jordan in ‘Creed III’ Entertainment Weekly News
  5. Director Michael B. Jordan turned to Jon Favreau, Denzel Washington, and Bradley Cooper as sounding boards for Creed III Bollywood Hungama
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Rebel Wilson says Ramona Agruma’s family ‘hasn’t been as accepting’ of their relationship: ‘It has been a lot harder on her’ – Yahoo Entertainment

  1. Rebel Wilson says Ramona Agruma’s family ‘hasn’t been as accepting’ of their relationship: ‘It has been a lot harder on her’ Yahoo Entertainment
  2. Rebel Wilson Discusses Being Mom Shamed BuzzFeed
  3. Rebel Wilson says girlfriend’s family ‘hasn’t been as accepting’ of relationship Page Six
  4. Rebel Wilson Reveals Girlfriend Ramona Agruma’s Family ‘Hasn’t Been as Accepting’ of Their Relationship: ‘It Has Been a Lot Harder on Her’ Yahoo Entertainment
  5. Rebel Wilson On Being ‘Mum-Shamed’ For Going To Leonardo DiCaprio’s Party After Her Daughter Was Born ETCanada.com
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Airline perks and elite status will be harder to earn this year

The new Delta SkyClub at Los Angeles International Airport (LAX), Terminals 2 and 3 where the reimagined state-of-the-art facilities will soon welcome millions of guests each year.

Media News Group | Long Beach Press-Telegram via Getty Images

When United Airlines gate agents call the first boarding group, Ted Cohen notices something he never saw in his decades crossing the globe as a music industry executive: crowds.

The “preboarding” group includes members of United Global Services, an invitation-only status for top customers, and United Premier 1K, an upper-level tier in the airline’s Mileage Plus frequent flyer program.

“It used to be two or three people, and you used to say, ‘Who is that?’ And now it’s a small army,” said Cohen, who leads a digital entertainment consulting firm and has lifetime elite status on United and American Airlines.

Welcome to air travel’s era of mass luxury.

Travelers willing to shell out more for tickets and popular rewards credit cards are swelling ranks in front cabins and airport lounges. Now airlines are trying to handle the surge of big spenders — without compromising the appeal of their lucrative loyalty programs and most expensive seats. This year, not everyone will make the cut.

The largest U.S. carriers — Delta Air Lines, American and United — are raising spending requirements to earn some elite frequent flyer tiers that grant free upgrades, early boarding, discounted or complimentary lounge memberships and other perks.

Executives say the richer requirements are the product of the pandemic. Airlines had extended frequent flyer status without requiring travelers to meet the usual annual thresholds because would-be passengers were sidelined. In the meantime, customers kept spending on their rewards credit cards, racking up points and perks along the way.

“We feel like we’re royals even though we’re not rich at all,” said Damaris Osorio, a 27-year-old based in New York who runs a vintage clothing business.

Osorio frequents airport lounges on trips booked with rewards points that she earned through strategic credit card use and sign-up bonuses. Last year she and her fiance traveled to Brazil, Chile, Argentina and Italy, all on flights she paid for with points.

She said she cares little about sitting in the front of the plane, but has a preference for the American Express Centurion Lounges, which she gets into with one of her Amex cards. Osorio realizes she’s not alone.

“You notice how much busier it’s getting at the lounges,” she said. “I go as early as possible to maximize what I’m taking away.”

Next month, Amex Platinum cardholders will be charged $50 for each guest they bring to a Centurion Lounge. Those cardholders can currently bring in two guests for free.

‘If everyone is special, no one feels special’

For the airlines, hordes of high spenders are a good problem to have two years after the pandemic drove them into a $35 billion hole, despite billions in taxpayer aid. Airlines are profitable again, with travel roaring back and flyers who are willing to pay up for a little bit more space or privacy on their trip.

Airlines’ lucrative credit card partnerships helped them stay afloat in the pandemic. They sell miles to credit card companies, and bringing in billions of dollars.

Now they have a lot of travelers itching to cash in rewards.

If they call biz class boarding and it’s like the start of the Indy 500 … it’s not going to be a pleasant experience.

Henry Harteveldt

founder of Atmosphere Research Group

Delta said in an investor presentation last month that premium products and non-ticket revenue will make up 57% of its sales this year, up from 44% in 2014 and 53% in 2019, before the pandemic. That category includes revenue from top-end international business-class seats, extra-legroom seats and other sources, such as its partnership with American Express.

After some customers complained about crowds and long lines at its Sky Club airport lounges, Delta said late last year that it will raise the prices and the requirements to gain access to those facilities. Earlier in 2022, it also instituted a three-hour time limit for lounge use and created a VIP line for high-status holders.

CEO Ed Bastian said recent policy changes aim to address pandemic-era status extensions and the rise of customers spending more for travel.

“We’ve got to address that in some way to be fair to everybody, because as they say, ‘If everyone’s special, no one feels special,'” Bastian said in an interview last month. “We’re trying to do it in a fair way.”

United’s chief customer officer, Linda Jojo, put it similarly at a recent industry conference. “If everybody has status then nobody has status,” she said.

In November, United said it was raising the requirements to earn status and perks.

United also opened a new mini-lounge at its hub at Denver International Airport, catering to customers on the go who are flying on regional feeder jets, a move that could help free up space in larger facilities for travelers hanging out longer.

United Airlines Polaris lounge at Newark Liberty International Airport

Leslie Josephs | CNBC

Last month, American Airlines said customers will have to spend or fly more to reach the lowest elite tier in its AAdvantage frequent flyer program. Customers will soon need 40,000 so-called loyalty points instead of 30,000 for Gold status.

Bigger space for big spenders

Delta, American, United and American Express have been opening bigger airport lounges to fit more travelers.

American and its trans-Atlantic partner British Airways in November opened new, high-end lounges at John F. Kennedy International Airport with showers, bars and lots of workspace. The three lounges roughly double the square feet that American previously offered at JFK to about 65,000 square feet, an airline spokeswoman said.

“There’s a tremendous demand for it, and we got to make sure that we are taking care of customers how they want to be taken care of,” American Airlines CEO Robert Isom said at the JFK lounge opening.

Several full-service carriers have also moved away from long-haul first class cabins in favor of more premium economy seats — in between business-class and standard coach seats — and larger business-class cabins that fit scores of travelers, particularly on long flights.

Many of the newer business-class seats are roomier and come with more amenities than first-class seats of the past.

A new American Airlines and British Airways lounge at John F. Kennedy International Airport, November 29, 2022.

Leslie Josephs | CNBC

American Airlines is planning to get rid of a separate first class on some older planes used to fly longer routes in favor of a single, expanded, business class featuring new suites with doors.

The airline said premium seats on its long-haul fleet will increase by more than 45% by 2026.

But with the expansion of that cabin comes the risk of diluting the premium feel, said Henry Harteveldt, a former airline executive and founder of Atmosphere Research Group.

“If they call biz class boarding and it’s like the start of the Indy 500 and you have 70 people jostling to get down the jet bridge, it’s not going to be a pleasant experience,” he said.

‘I don’t sit behind the wing’

With demand still strong, redeeming miles for flights this year might cost more.

Michael Calarco, a part-time consultant who helps travelers book trips with their rewards points, said it’s been harder to find seats lately because planes are flying so full after travel restrictions lifted, including to international destinations.

He recommends flyers be as flexible as possible with their dates if they want to cash in their points for a trip, and to avoid major holidays.

“There’s not much I can do if someone wants to go to the Maldives two months away,” he said.

Some travelers say comfort is worth cashing in chunks of the points they’ve been sitting on.

“I don’t sit behind the wing,” said Mark Ophaug, 40, who works at an educational technology company and has a top-tier status with United’s Mileage Plus program. He and his husband are planning to visit his in-laws in Buenos Aires this year and plan to use United PlusPoints to upgrade to lie-flat seats.

“It’s a long flight, and I want to lie down,” Ophaug said.

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Flu and RSV arrived earlier and hit harder this year. Could COVID be to blame?

Respiratory syncytial virus — or RSV — was the first virus to hit much earlier than normal this season. It flooded pediatric hospitals in October and November instead of during its usual peak in late December to mid-February, creating a dire shortage of pediatric beds.

Normally, the virus poses a particular risk to infants because it can inflame and clog their lungs’ tiny airways.

But this year, RSV hospitalized a much broader group of children, including older kids with no underlying health problems.

“I haven’t experienced the breadth of ages of patients with severe disease that I have been seeing in the last few weeks,” said Dr. Chadi El Saleeby, a pediatric infectious disease specialist at Massachusetts General Hospital.

Many experts have suggested that RSV was worse this year because of an “immunity debt” or “immunity gap” from several years of social distancing and COVID precautions. Dr. Paul Offit, director of the vaccine education center and professor of pediatrics at Children’s Hospital of Philadelphia, said much of the country was still masking, social distancing, and being cautious last winter.

“That’s not true this year. People are back,” Offit said. “COVID is no longer changing how we live, work, or play.”

With fewer cases of flu and RSV over the last few years, people haven’t received the “booster” of immunity that a typical annual virus would create.

“It may be the same reason flu is definitely worse this year,” he said.

Other scientists are skeptical that mitigation measures played any role in current trends. Michael Osterholm, director of the Minnesota Center of Excellence for Influenza Research and Surveillance, said at a conference in Boston in November that the emergence of H1N1 in 2009 similarly disrupted normal patterns of RSV and flu the following winter. But at the time people didn’t take mitigation measures.

“There was something going on with that virus impacting other respiratory pathogens,” Osterholm said.

Scientists also point out that RSV isn’t just more widespread this year but also appears more severe.

In the past, hospitals would provide hydration, suction, and some oxygen to patients diagnosed with RSV, but this year they had to provide more extensive respiratory support to a larger number of patients, said El Saleeby.

Low population immunity may be part of the answer, but El Saleeby said infection with multiple viruses at one time may also play a role. At MGH, several children tested positive not only for RSV, but also for enterovirus and influenza — which also arrived earlier in the season than normal.

“These respiratory difficulties can be made worse by having multiple viruses at the same time,” said El Saleeby.

Ryan Gregory, a Canadian evolutionary biologist and professor at the University of Guelph in Ontario, agreed there are likely multiple factors at play. He pointed to a recent small study published in the Lancet Respiratory Medicine that found that contracting COVID during pregnancy could change the lung development of the fetus, resulting in children born with lower lung volume.

“That could account for why so many newborns are getting so sick,” Gregory said.

Though scientists have wondered if the recent surge of RSV was caused by a new strain of the virus, early analysis shows that doesn’t appear to be the case. Looking at the viral genomes of patients coming to MGH and some sites, researchers discovered there were several versions of the existing virus circulating, rather than one predominant new strain, according to a preliminary analysis posted online last Friday.

However, more strains of RSV-A appear to be circulating this year, which is normally more severe than RSV-B, and that probably is contributing to the increased severity of the recent surge, said Dr. Jacob Lemieux, an infectious disease doctor at MGH who co-led the research.

Other scientists suggest that COVID infection may be changing how the human body responds to infections. Sometimes referred to as “immunity theft,” some have hypothesized that COVID could impair people’s immune systems either temporarily or longer term.

One controversial scientific theory, suggested by Anthony Leonardi, an immunologist and graduate student at the Johns Hopkins Bloomberg School of Public Health, posits that COVID infection can wear down a key part of the immune system known as T cells, which contain much of the “memory” a person’s body has of previous infections. Multiple COVID infections could overactivate T cells, either prematurely aging them, engaging them so significantly they accidentally cause organ damage, or taxing them for such a long period of time that they may become less effective against other viruses.

There are few clear answers, but the University of Guelph’s Gregory said it is an urgent question that the scientific community needs to get right.

“If it’s just an immunity [gap], if it’s just a numbers game and you ride it out, this will be a bad year and we’re caught up, and next year should be fine,” he said. “The consequences of it not being that, if it’s immunity theft, are really serious. This year might not be the only bad year.”


Jessica Bartlett can be reached at jessica.bartlett@globe.com. Follow her on Twitter @ByJessBartlett.



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Flu variant that hits kids and seniors harder than other strains is dominant in U.S. right now

A sign advertising flu shots is displayed at a Walgreens pharmacy on January 22, 2018 in San Francisco, California. A strong strain of H3N2 influenza has claimed the lives of 74 Californians under the age of 65 since the flu season began in October of last year.

Justin Sullivan | Getty Images

A variant of the flu that hits kids and seniors worse than other strains of the virus is dominant in the U.S. right now, setting the country up for a potentially bad flu season.

Public health labs have detected influenza A(H3N2) in 76% of the more than 3,500 respiratory samples that have tested positive for the flu and were analyzed for the virus subtype, according to a surveillance report published Friday by the Centers for Disease Control and Prevention.

The H3N2 variant has been associated with more severe flu seasons for children and the elderly in the past, according to Dr. Jose Romero, director the CDC’s National Center for Immunization and Respiratory Disease.

“There are also early signs of influenza causing severe illness in precisely these two groups of individuals this season,” Romero told reporters on a call earlier this month.

The flu hospitalization rate has surged to a decade high this season. Overall, about 8 people per 100,000 are being hospitalized with the flu right now but seniors and the youngest children are much harder hit than other age groups, according to CDC data.

The hospitalization rate for seniors is more than double the general population at 18 per 100,000. For kids younger than age five, the hospitalization rate is about 13 per 100,000.

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At least 4.4 million people have fallen ill with the flu, 38,000 have been hospitalized, and 2,100 have died since the season started. Seven kids have died from the flu so far this season.

“When we have more H3N2, we usually have a more severe flu season — so longer duration, more children affected, more children with severe disease,” said Dr. Andi Shane, a pediatrician and infectious disease expert at Children’s Healthcare Atlanta.

The other influenza A variant, H1N1, is generally associated with less severe seasons compared with H3N2, Shane said. H1N1 makes up about 22% of sample that have tested positive for flu and were analyzed for a subtype, according to CDC.

The percentage of patients reporting symptoms similar to the flu, a fever of 100 degrees or greater plus a sore throat or cough, is the highest in Virginia, Tennessee, South Carolina, Alabama and Washington D.C right now, according to CDC.

Respiratory illnesses are also very high in Arkansas, Colorado, Georgia, Kentucky, New Jersey, Maryland, Mississippi, New Mexico, North Carolina and Texas, according to CDC.

The CDC recommends that everyone 6 months or older get a flu shot. Children younger than age 8 who are receiving the vaccine for the first time should get two doses for the best protection.

The flu vaccine is normally 40% to 60% effective at preventing illness, but people who do still get sick are less likely to end up in the hospital or die, according to the CDC.

Public health officials are also encouraging people to stay home when they are sick, cover coughs and sneezes and wash hands frequently. Those who want to take extra precautions can consider wearing a facemask indoors in public.

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U.S. seeking to make it harder for Iran to sell drones to Russia

WASHINGTON, Oct 18 (Reuters) – The United States will continue to take “practical, aggressive” steps to make it harder for Iran to sell drones and missiles to Russia, State Department deputy spokesperson Vedant Patel said on Tuesday, adding that Washington had a number of tools to hold both Moscow and Tehran accountable.

Patel, speaking at a daily press briefing, said such measures could include sanctions and export controls.

“We will continue to take practical, aggressive steps to make these weapons sales harder, including sanctions, export control actions against any entities involved,” Patel said.

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“Russia deepening an alliance with Iran is something the entire world – especially those in the region – should view as a profound threat.”

A drone is launched during a military exercise in an undisclosed location in Iran, in this handout image obtained on August 25, 2022. Iranian Army/WANA (West Asia News Agency)/Handout via REUTERS

Ukraine has accused Russia of using Iranian-made Shahed-136 drones in attacks in recent weeks. Iran denies supplying them and on Tuesday the Kremlin also denied using them.

Reuters reported on Tuesday that Iran has promised Russia it would supply them with surface to surface missiles, in addition to more drones. read more

The U.S. State Department assessed that Iranian drones were used on Monday in a morning rush hour attack on the Ukrainian capital Kyiv, a U.S. official said. White House spokesperson Karinne Jean-Pierre also accused Tehran of lying when it said Iranian drones were not being used by Russia in Ukraine.

The United States in September imposed sanctions on an Iranian company it accused of coordinating military flights to transport Iranian drones to Russia and three other companies it said were involved in the production of Iranian drones. read more

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Reporting by Daphne Psaledakis, Humeyra Pamuk and Doina Chiacu, Editing by Rosalba O’Brien

Our Standards: The Thomson Reuters Trust Principles.

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Mortgage rate is over 7% and it’s getting harder to qualify for loan

JB Reed | Bloomberg | Getty Images

It’s a double whammy for would-be homebuyers. Not only are interest rates soaring, it’s getting harder to qualify for a loan.

The average rate on the popular 30-year fixed mortgage climbed over 7% at the end of last week, according to Mortgage News Daily, and is expected to hit around 7.125% on Tuesday. It’s been over 7% for several days.

Meanwhile, mortgage credit availability is now at the lowest level since March 2013, which was when housing was in a slow recovery from the financial crisis at the end of the prior decade. It fell for the seventh consecutive month in September, down 5.4% from August, according to a monthly index from the Mortgage Bankers Association.

While lenders may be desperate for business, as mortgage demand drops due to higher rates, they are also more concerned about a weaker economy, which could lead to higher delinquencies. Executives and economists have warned the U.S. could fall into a recession in the coming months as the Federal Reserve hikes rates to battle high inflation.

“There was a smaller appetite for lower credit score and high [loan-to-value] loan programs,” Joel Kan, a Mortgage Bankers Association economist, said in a release.

Mortgage delinquencies, at the moment, sit near record lows. While new foreclosure actions rose 15% from July to August, they were still 44% below pre-pandemic levels, according to Black Knight, a mortgage software and analytics company.

Credit availability fell the most for jumbo loans, which more borrowers today have to use due to higher home prices, according to the Mortgage Bankers Association. Higher prices also have more borrowers turning to adjustable-rate mortgages, because they offer lower interest rates. These loan rates can be fixed for up to 10 years, but they are considered riskier mortgages.

Borrowers are clearly concerned that mortgage rates will move even higher. While mortgage rates don’t follow the federal funds rate exactly, they are influenced heavily by the Fed’s policy.

“The Fed is determined to hike rates as high as it can and keep them there as long as it can, even if that means the economy suffers,” Matthew Graham, chief operating officer of Mortgage News Daily, wrote on its website.

Graham noted the Fed is not considering mortgage rates or the housing market because home prices are overheated and a correction is “good and necessary.”

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