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China hailed a property developer with $64 billion in revenue as a role model. Now the country’s property crisis threatens to send it into default too – Yahoo Finance
- China hailed a property developer with $64 billion in revenue as a role model. Now the country’s property crisis threatens to send it into default too Yahoo Finance
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Success of experimental Alzheimer’s drug hailed as ‘historic moment’ | Alzheimer’s
An experimental drug has slowed the rate of decline in memory and thinking in people with early Alzheimer’s disease in what is being described as a “historic moment” for dementia treatment.
The cognition of Alzheimer’s patients given the drug, developed by Eisai and Biogen, declined by 27% less than those on a placebo treatment after 18 months. This is a modest change in clinical outcome but it is the first time any drug has been clearly shown to alter the disease’s trajectory.
“This is a historic moment for dementia research, as this is the first phase 3 trial of an Alzheimer’s drug in a generation to successfully slow cognitive decline,” said Dr Susan Kohlhaas, the director of research at Alzheimer’s Research UK. “Many people feel Alzheimer’s is an inevitable part of ageing. This spells it out: if you intervene early you can make an impact on how people progress.”
In the study, which enrolled roughly 1,800 patients with early stage Alzheimer’s, patients were given twice-weekly infusions of the drug, called lecanemab. It was also shown to reduce toxic plaques in the brain and slow patients’ memory decline and ability to perform day-to-day tasks.
About a fifth of patients experienced side-effects, including brain swelling or brain bleeding visible on PET scans, with about 3% of those patients experiencing symptomatic side-effects.
The results offer a boost to the “amyloid hypothesis”, which assumes that sticky plaques seen in the brains of dementia patients play a role in damaging brain cells and causing cognitive decline.
A series of previous drug candidates had been shown to successfully reduce levels of amyloid in the brain, but without any improvement in clinical outcomes, leading some to question whether the research field had been on the wrong track.
Rob Howard, a professor of old age psychiatry at University College London (UCL), said: “This is an unambiguously statistically positive result and represents something of an historic moment when we see the first convincing modification of Alzheimer’s disease. God knows, we’ve waited long enough for this.”
Eisai and Biogen are expected to apply for regulatory approval in the US and Europe by the end of the year. If approved, healthcare providers will have difficult decisions about whether to fund the drug, which requires infusions every two weeks, and who will be eligible for it because the clinical improvements seen by patients fall just below a widely accepted benchmark.
On a 14-point scale used to assess Alzheimer’s progression, patients on the drug scored 0.45 higher than those on the placebo treatment, with an Alzheimer’s patient being expected to decline by about 1 point a year.
Howard said: “The accepted minimum worthwhile difference ranges from 0.5 to 1.0 points, [meaning] that there are going to be some very difficult conversations and decisions in the next weeks and months.”
The overall benefits will depend on whether patients on the drug maintain a better trajectory beyond the first 18 months, but the latest data cannot answer that question.
There are also questions about whether the drug could slow decline at an even earlier stage. Eisai is recruiting people with a high risk of Alzheimer’s who have not yet developed symptoms to take part in further trials to try to help answer this.
The prospect of an effective Alzheimer’s therapy will focus attention on the ability of healthcare services to deliver treatments to the almost 1 million people affected in the UK – one in every 14 people aged 65 years and over.
According to Alzheimer’s Research UK, only one in three psychiatry services would be ready to deliver a new treatment within a year and, in the UK, many patients are diagnosed at a much later stage than those who took part in the latest trial.
“This will require a radical change in how we deliver our services,” said Prof Jon Schott, the chief medical officer of Alzheimer’s Research UK and a professor of neurology at UCL.
“If this is licensed and this gets through Nice [the National Institute for Health and Care Excellence], the demand will be huge. We’re not ready to deliver this at scale and we need to address that now.”
Paul McCartney’s Glastonbury show hailed as ‘phenomenal’ | Glastonbury 2022
Paul McCartney’s history-making Glastonbury set was hailed as one of the greatest headline performances of this generation as a crowd of more than 100,000 people gathered at the festival’s famous Pyramid stage to watch him play.
He was joined on stage by Bruce Springsteen and Foo Fighters’ Dave Grohl – and even sang a duet with his old bandmate John Lennon, using special effects pioneered by the Lord of the Rings director Peter Jackson.
Eyebrows had been raised when it was announced that McCartney, who turned 80 last week, would top the bill, becoming the oldest headliner in Glastonbury’s 52-year history.
But any doubts were shredded when McCartney finished a near-three hour set with a dramatic pyrotechnics display and a mass singalong to Let It Be, Hey Jude and Live and Let Die.
“It exceeded all expectations,” beamed Richard Martin, 75, part of the biggest crowd the Pyramid stage had ever seen.
He said: “Although I’m almost his age, I’ve never seen the Beatles – my wife has, she was one of those screaming teenagers – but he just nailed it.
“He was brilliant. Of course he’s a pro – he’s been at it for half a century. People behind us were in their 20s and they knew the songs backwards – that’s terrific testimony to the durability of the songs.”
Almost 4 million people tuned in to watch from home, and drew rave critical reviews. The Guardian’s Alexis Petridis said McCartney’s biggest hits were “about as thrilling as pop music gets,” while the Independent described it as “far and away the best this writer has seen on the Pyramid stage in 30 years of Glastonburies”.
The Sunday Telegraph hailed it as “one of the most thrilling, uplifting, banger-filled, star-studded sets this 50-plus-year-old festival had ever seen”.
Some festival-goers had camped out all day to get close to the Pyramid stage and it turned out to be a sensible decision. The crowd easily reached 100,000 people, ranking alongside one of the biggest Pyramid stage attendances alongside the Rolling Stones in 2013.
By 9pm, half an hour before McCartney took to the stage, it was impossible to get anywhere near the front as huge masses of people packed in from all corners of the 900-acre site.
“It was incredible. Musically it was up there with one of the most seminal moments of my life,” said James Jack, 35, after screaming along to the Bond hit Live and Let Die – a moment he said was fulfilling a childhood dream: “When you watch the films with your dad when you’re about six. That was a boyish moment for me, it really got me going. It’s the sort of thing you tell your grandkids about.”
Grohl, who had to pull out of a headline show in 2015 after breaking his leg, became Macca’s surprise sideman for I Saw Her Standing There, immediately followed by Band on the Run. Even before Bruce “the boss” Springsteen arrived, the crowd was levitating with delight.
Grohl and Springsteen, rock icons who had flown from the US especially for the set, looked utterly overjoyed to be joining McCartney on stage.
“It was phenomenal,” said 25-year-old Sorcha Ingram. “I had the time of my life. I’ve never experienced anything like it. I was obsessed with the Beatles when I was younger, it’s where my music taste stems from. This was the first time I’d watched him, and my first time at Glastonbury. It’s a historic moment, a once-in-a-lifetime opportunity.”
“He’s a proper legend,” said Keith Burnet, 59. “He actually did a really good gig that covered his whole career at his own time and pace.”
But he faced some criticism for showing a “very ill-advised” clip of Johnny Depp during his Glastonbury headline set.
A clip of Depp appeared on a large screen during My Valentine, a love song written for McCartney’s wife, Nancy Shevell.
One Twitter user wrote: “I am so sad that a man like Paul McCartney has chosen to give Johnny Depp a platform. Once again, domestic abuse survivors are completely mocked.”
McCartney and Depp are reportedly close friends, and the American actor featured in video footage during the 80-year-old’s recent Get Back tour in the US.
However, there was no getting away from the fact that most in attendance would not get the chance to see McCartney perform again – and that made the night more special.
The NME said he had thrown “absolutely everything he has – which is saying something for an actual Beatle – at Glastonbury 2022, sounding like a man who, frankly, knows he might not do this again.”
Officer hailed as hero testifies at Capitol riot trial
A police officer lauded for his bravery during the U.S. Capitol riot testified on Monday that a man carrying a Confederate battle flag jabbed at him with the flagpole before joining the mob that chased him up a staircase.
In his first public testimony since the Jan. 6, 2021, siege, Capitol Police officer Eugene Goodman described his encounter with the flag-toting Delaware man, Kevin Seefried, and his adult son, Hunter, at their trial on charges that they stormed the Capitol together.
Goodman has been hailed as a hero for leading a group of rioters away from Senate chamber and up a set of stairs to an area where other officers were waiting. Goodman also directed Sen. Mitt Romney, R-Utah, to turn around and head away from the mob.
Goodman recalled seeing Kevin Seefried standing alone in an archway and telling him to leave. Instead, Seefried cursed at him and jabbed at the officer with the base end of the flagpole three or four times, Goodman said
“He was very angry. Screaming. Talking loudly,” Goodman said. “Complete opposite of pleasant.”
U.S. District Judge Trevor McFadden is hearing testimony without a jury for the Seefrieds’ bench trial, which started Monday. The Seefrieds waived their right to a jury trial, which means McFadden will decide their cases.
Widely published photographs showed Kevin Seefried carrying a Confederate battle flag inside the Capitol after he and his son entered the building through a broken window.
The charges against both Kevin and Hunter Seefried include a felony count of obstruction of an official proceeding, the joint session of Congress for certifying Joe Biden’s victory over then-President Donald Trump in the 2020 presidential election.
During the trial’s opening statements, defense attorneys said the Seefrieds never intended to interfere with the Electoral College vote count.
“Indeed, (Kevin Seefried) was not even aware that the electoral count was happening or was happening in the Capitol,” one of his lawyers, Elizabeth Mullin, told the judge.
Goodman, however, testified that Kevin Seefried was standing next to a rioter who profanely asked where members of Congress were and where they would be counting votes. Goodman said it was clear to him that the rioters were there to disrupt the proceedings.
“Were you concerned for your safety?” Assistant U.S. Attorney Brittany Reed asked him.
“Yes,” Goodman said.
Before his encounter with the mob inside the Capitol, Goodman joined other officers in trying to hold back rioters as they clashed with police outside the building.
“It was like something out of medieval times, with one huge force clashing with another opposing force,” Goodman said. “I’ve never seen anything like that ever.”
Goodman said he had to retreat inside the building after getting pepper sprayed and exposed to tear gas deployed by police.
The Seefrieds aren’t accused of assaulting any officers.
Mullin conceded that Kevin Seefried is guilty of two misdemeanor charges that he knowingly entered a restricted building and illegally demonstrated in the Capitol.
Hunter Seefried, then 22, may have acted “stupidly” but didn’t intend to block Congress from certifying the election results, defense attorney Edson Bostic said.
The Seefrieds traveled to Washington from their home in Laurel, Delaware, to hear Trump’s speech at the “Stop the Steal” rally on Jan. 6.
They climbed over a wall near a stairwell and scaffolding in the northwest section of the Capitol and were among the first rioters to approach the building near the Senate Wing Door, according to prosecutors. After watching other rioters use a police shield and a wooden plank to break a window, Hunter Seefried used a gloved fist to clear a shard of glass in one of the broken windowpanes, prosecutors said.
In a court filing, prosecutors said the Confederate battle flag that Kevin Seefried brought from home was “a symbol of violent opposition to the United States government.”
Mullin said Seefried didn’t intend “to send any kind of message” by carrying the flag into the Capitol and regrets doing so.
McFadden, whom Trump nominated in 2017, is the only judge to a hold a bench trial for a Capitol riot case so far.
In April, he acquitted New Mexico resident Matthew Martin of misdemeanor charges that he illegally entered the Capitol and engaged in disorderly conduct after he walked into the building.
In March, McFadden acquitted a New Mexico elected official of engaging in disorderly conduct but convicted him of illegally entering restricted Capitol grounds.
McFadden has criticized prosecutors’ handling of Capitol riot cases. He suggested that the Justice Department has been unjustly tougher on Capitol riot defendants compared with people arrested at protests against police brutality and racial injustice after George Floyd’s 2020 murder by a Minneapolis police officer.
On Tuesday, U.S. District Judge Colleen Kollar-Kotelly is scheduled to preside over a bench trial for Jesus Rivera, a Pensacola, Florida, man charged with four riot-related misdemeanors. President Bill Clinton nominated Kollar-Kotelly to the court in 1997.
At least four other Capitol riot defendants have bench trials scheduled for this year.
Juries have unanimously convicted five Capitol riot defendants of all charges, a perfect record for prosecutors so far. More than 300 other defendants have pleaded guilty to riot offenses, mostly misdemeanors punishable by no more than one year in prison. Approximately 100 others have trial dates in 2022 or 2023. More than 800 people have been charged with federal crimes related to the Jan. 6 attack.
Quick-Thinking KFC Worker Helps Save Alleged Kidnapping Victim After She Secretly Slips Him Note ‘Begging For Help’
A KFC employee in Memphis, Tennessee, is being hailed a hero after reportedly helping police rescue a woman who secretly left a note behind claiming she was being held against her will.
The victim and her alleged kidnapper left KFC, and the employee immediately called the police to report the purported kidnapping, Fox News reported.
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The woman’s desperate note begging for help and the subsequent phone call to authorities led to the prompt arrest of Diego Glay, 23, Sunday after a brief foot chase with Memphis police officers.
“Officers were advised that a female had written a note begging for help. The female that wrote the note was still on the business lot accompanied by a male,” a report from the Memphis Police Department reads. “As officers approached the couple, the man ran on foot. After a brief foot chase, he was apprehended.”
The victim reportedly told authorities she was in a relationship with Glay and was punched in the face by the accused when she tried to leave.
She also said he took her phone and wouldn’t let her out of his sight for days, according to WHBQ-TV.
The victim, reportedly from another state, had purportedly gone to Tennessee to meet Glay. However, authorities alleged he “held her physically against her will with physical assaults, threats, and being armed with a handgun.”
Glay was charged with kidnapping and evading arrest, and his bond was set at $35,000.
The quick-thinking KFC employee is yet to be named, but the individual’s actions thankfully helped someone in need. That kind deed saved the victim from unimaginable pain and suffering.
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Blood marker identified for babies at risk of SIDS hailed as ‘breakthrough’
A newborn baby holds on a nurse’s finger at the maternity ward of the children hospital in Kabul, Afghanistan October 24, 2021. REUTERS/Jorge Silva/
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NEW YORK, May 13 (Reuters) – A team of Australian researchers have identified a biochemical marker in the blood that could help identify newborn babies at risk for sudden infant death syndrome (SIDS), a breakthrough they said creates an avenue to future tragedy-preventing interventions.
In their study, babies who died of SIDS had lower levels of an enzyme called butyrylcholinesterase (BChE) shortly after birth, the researchers said. BChE plays a major role in the brain’s arousal pathway, and low levels would reduce a sleeping infant’s ability to wake up or respond to its environment.
The findings are game changing and not only offer hope for the future, but answers for the past, study leader Dr. Carmel Harrington of The Children’s Hospital at Westmead in Australia said in a statement.
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“An apparently healthy baby going to sleep and not waking up is every parent’s nightmare and until now there was absolutely no way of knowing which infant would succumb,” Harrington said. “But that’s not the case anymore. We have found the first marker to indicate vulnerability prior to death.”
Using dried blood spots taken at birth as part of a newborn screening program, Harrington’s team compared BChE levels in 26 babies who later died of SIDS, 41 infants who died of other causes, and 655 surviving infants.
The fact that levels of the enzyme were significantly lower in the infants who subsequently died of SIDS suggests the SIDS babies were inherently vulnerable to dysfunction of the autonomic nervous system, which controls unconscious and involuntary functions in the body, the researchers said.
The Sydney Children’s Hospital Network in Australia called the discovery “a world-first breakthrough.”
A failure to wake up when appropriate “has long been considered a key component of an infant’s vulnerability” to SIDS, the research team said in The Lancet’s eBio Medicine.
SIDS is the unexplained death of an apparently healthy infant while asleep. Harrington lost her own child to SIDS 29 years ago and has dedicated her career to researching the condition, according to the statement.
Further research “needs to be undertaken with urgency” to determine whether routine measurement of BChE could potentially help prevent future SIDS deaths, the investigators said.
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Reporting by Nancy Lapid; Editing by Caroline Humer and Bill Berkrot
Our Standards: The Thomson Reuters Trust Principles.
Discovery of bacteria linked to prostate cancer hailed as potential breakthrough | Prostate cancer
Scientists have discovered bacteria linked to aggressive prostate cancer in work hailed as a potential revolution for the prevention and treatment of the most deadly form of the disease.
Researchers led by the University of East Anglia performed sophisticated genetic analyses on the urine and prostate tissue of more than 600 men with and without prostate cancer and found five species of bacteria linked to rapid progression of the disease.
The study does not prove that the bacteria drive or exacerbate prostate cancer, but if work now under way confirms their role, researchers can develop tests to identify men most at risk and potentially find antibiotics to prevent the cancer from claiming thousands of lives each year.
“This is an exciting discovery that has the potential to truly revolutionise treatment for men,” said Dr Hayley Luxton of Prostate Cancer UK, which co-funded the research.
Writing in the journal European Urology Oncology, the scientists describe how their genetic investigations found five species of bacteria – three new to science – that were associated with advanced prostate cancer. Men who had one or more of the species in their urine, prostate or tumour tissue were 2.6 times more likely to see their early stage cancer progress to advanced disease than men who did not.
Lead scientist Colin Cooper, a professor of cancer genetics at the University of East Anglia, said it was possible the bacteria are not involved in the disease. For example, men with more aggressive prostate cancer may have immune system deficiencies that allow certain bacteria to thrive. But the researchers strongly suspect the microbes are involved, just as Helicobacter pylori infections raise the risk of stomach cancer.
“If you knew for sure that a species of bacteria was causing prostate cancer, you could work out an antibiotic to remove it and that would prevent progression, one would hope,” Cooper said. But this is not as straightforward as it sounds, he cautioned. “There are many complications. Antibiotics don’t get into the prostate very well and you would need to choose an antibiotic that only kills certain bacteria,” he said.
While prostate cancer is the most common form of the disease found in men, in many cases patients die with the disease rather than because of it. The more aggressive forms of prostate cancer claim about 12,000 lives in the UK each year.
Prof Rosalind Eeles, a cancer geneticist on the study at the Institute of Cancer Research in London, said it was a “very interesting result” to find “novel micro-organisms” in prostate cancer cases. “It is not yet known if they are causative but if this could be proven then we have a potential route for prevention,” she said. “The way that we may be able to prove this is to look to see if these organisms are never found in prostate samples which have no cancer.”
Genetic information on the microbes has already allowed the scientists to piece together how they may behave in the body, including what toxins and other substances they might release. This has led them to develop half a dozen hypotheses around how the bugs could cause prostate cancer.
“We currently have no way of reliably identifying aggressive prostate cancers, and this research could help make sure men get the right treatment for them,” Luxton added.
“If the team can demonstrate that these newly identified bacteria can not only predict, but actually cause aggressive prostate cancer, for the first time we may actually be able to prevent prostate cancer occurring. This would be a huge breakthrough that could save thousands of lives each year.”
Diet that can beat diabetes even if you are slim is hailed as a ‘game-changer’ by researchers
Diet that can beat diabetes even if you are slim is hailed as a ‘game-changer’ by researchers
- People with type 2 diabetes could reverse their condition with a new diet
- Even if not overweight, a diet of shakes and vegetables can reverse the diabetes
- The study could help over 400,000 ‘normal-weight’ people with the condition
A ‘game-changing’ diet can help people with type 2 diabetes reverse the condition – even when they are not overweight.
Experts previously found it can be reversed through dramatic weight loss, with most sufferers being overweight or obese.
Now a study putting ‘normal-weight’ people on a diet of shakes and vegetables has found they, too, can do it.
A combination of nutritional shakes and vegetables can help reverse type 2 diabetes in people, even if they are not overweight
The diet of shakes and veg (file photo) , followed by weeks of eating healthily, saw 70% of those in the trial reverse their diabetes
Around 10 per cent of those with diabetes fall into this category – more than 400,000 people across the UK.
Researchers led by the University of Newcastle recruited 20 people with a normal body mass index (BMI) and type 2 diabetes.
Most were found to have a high amount of fat in their liver or pancreas, putting them in a group known as TOFIs – thin on the outside and fat on the inside.
But losing weight on the shakes and veg diet, followed by weeks of eating sensibly, saw 70 per cent of those in the trial reverse their diabetes.
Professor Roy Taylor, who presented the results at the 2022 Diabetes UK Professional Conference this week, said: ‘Everyone has a weight threshold. Above that, they might develop type 2 diabetes. For the majority who have had diabetes for less than six years, they can reverse it through careful weight loss in consultation with a doctor.’
The study group were taken off their medication and put on a diet of nutritional shakes and veg for two to four weeks.
Half went into remission immediately, and another four after repeating the diet once or twice more.
Twitter CEO’s weeks-long paternity leave hailed by fellow dads | Twitter
Twitter’s new CEO, Parag Agrawal, is reportedly taking a “few weeks” off for paternity leave after the birth of his second child, a move that drew cheers from other fathers as a positive step towards normalizing men taking time off for childcare.
The 37-year-old became CEO of the company in November when its co-founder Jack Dorsey stepped down.
Agrawal’s leave was announced last week but it wasn’t immediately clear when it’s scheduled to begin. Twitter did not immediately respond to the Guardian’s request for further information.
“At Twitter, we encourage and fully support employees taking parental leave in whatever way works best for each person,” Laura Yagerman, the company’s head of corporate communications, told the Washington Post.
She added that the decision was “personal” and that the company had designed a program that is “customizable” and can include up to 20 weeks of “flexible” leave.
Agrawal’s decision is being lauded by other fathers and co-workers.
“Thank you @paraga for leading by example and taking paternity leave,” tweeted Ned Segal, Twitter’s chief financial officer. “I wish leaders did this when I was early in my career and becoming a father.”
“Proud that Twitter and our CEO Parag Agrawal are leading the way here, ensuring ALL parents are able to take advantage of this most special time for their families,” Brenden Lee, of Twitter’s corporate communications department, wrote in a post on LinkedIn.
Lee’s post drew comments from other fathers cheering Agrawal on. “Kudos to him for leading by example. I remember the guilt I felt when I took a week off following the births our daughters (who are now 7 and 9),” Jimmy Moock, a partner at a PR firm in Philadelphia, commented on Lee’s post.
Agrawal’s decision is by no means the norm, with most American men taking less than 10 days off the job, according to the Department of Labor, despite the benefits for both parents and children. But it is another step in a path being paved by other tech leaders, including Meta’s CEO, Mark Zuckerberg, and the Reddit co-founder Alexis Ohanian.
In 2015 and 2017, Zuckerberg took two months of paternity leave after the births of his daughters. Meanwhile, Ohanian has become a champion of the paternity leave movement.
Pete Buttigieg, the US transportation secretary, also took paternity leave last fall when he and his husband welcomed their children. He faced a backlash for doing so and addressed it by saying America had a lot of “catching up” to do on the issue.
The US ranks among the least generous countries in the world when it comes to paid paternity and maternity leave. While some cities and states have mandates for paid parental leave, there is no paid leave plan for mothers and fathers at a federal level.