Tag Archives: fever

Swift fever hits Melbourne as crowds swarm for first of record-breaking shows | A Current Affair – A Current Affair

  1. Swift fever hits Melbourne as crowds swarm for first of record-breaking shows | A Current Affair A Current Affair
  2. Photos of Taylor Swift’s Eras Tour Concerts in Melbourne, Australia PEOPLE
  3. Rebel Wilson and MAFS star Olivia Frazer lead the celebrities flocking to Taylor Swift’s hotly-anticipated con Daily Mail
  4. Taylor Swift Issues PSA About Getting ‘Creative’ With Surprise Songs, Delivers ‘Come Back… Be Here’ & ‘Daylight’ Mashup Billboard
  5. Taylor Swift’s Eras Tour Wristbands in Melbourne Give a Special Nod to Friendship Bracelet Trend Yahoo Life

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As Dengue Fever Fears Grow In U.S., First Prevention Pill Has Promising Trial – Forbes

  1. As Dengue Fever Fears Grow In U.S., First Prevention Pill Has Promising Trial Forbes
  2. First pill for dengue shows promise in human challenge trial Reuters
  3. J&J bites back against dengue, linking antiviral to protection from infection in challenge trial FierceBiotech
  4. Janssen Announces Promising Antiviral Activity Against Dengue in a Phase 2a Human Challenge Model – Janssen Announces Promising Antiviral Activity Against Dengue in a Phase 2a Human Challenge Model Johnson & Johnson
  5. BREAKTHROUGH: First-ever successful dengue fever pill may save millions of lives Geo News
  6. View Full Coverage on Google News

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Discovery in mosquitoes could lead to new strategy against dengue fever and other mosquito-borne vectors – Phys.org

  1. Discovery in mosquitoes could lead to new strategy against dengue fever and other mosquito-borne vectors Phys.org
  2. Discovery lead to better methods for reducing mosquito-to-human transmission of deadly viruses News-Medical.Net
  3. New insights could lead to better methods of reducing mosquito-borne viruses IOL
  4. Weill Cornell Lab Uncovers New Information About Malaria Transmission Pathway Cornell University The Cornell Daily Sun
  5. Disease-carrying mosquitoes to plague London by mid-century, experts warn The Telegraph
  6. View Full Coverage on Google News

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New AI app sparks baby fever, but will it lead to more child commodification? – Catholic News Agency

  1. New AI app sparks baby fever, but will it lead to more child commodification? Catholic News Agency
  2. Artificial intelligence: Is Remini safe to use? Remini, baby AI generator takes TikTok by storm as some raise security concerns WLS-TV
  3. Ad campaign in Germany sounds alarm about protecting children’s digital privacy | ABCNL ABC News
  4. AI-Generated Video Shows Dangers of Sharing Children’s Information Online: Deepfake Ad Shows Potential Harm Tech Times
  5. App shows what your future children could look like – But, is it safe? ABC 7 Chicago
  6. View Full Coverage on Google News

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‘Barbie’ & ‘Oppenheimer’ Fever Spills Into Monday: Greta Gerwig Pic Notches Warner Bros Record, Nolan Epic Strong With $12M+ – Box Office – Deadline

  1. ‘Barbie’ & ‘Oppenheimer’ Fever Spills Into Monday: Greta Gerwig Pic Notches Warner Bros Record, Nolan Epic Strong With $12M+ – Box Office Deadline
  2. ‘Barbie’ explained: Which scene did the studio want cut? Why are conservatives outraged? What are the best cameos? Yahoo Entertainment
  3. Oppenheimer and the triumph of Christopher Nolan – The Spectator World The Spectator World
  4. I saw Barbie and Oppenheimer opening weekend — and one is obviously better Tom’s Guide
  5. This One Scene In “Barbie” Is Making Everyone Feel “Called Out” By How Accurate It Is, And The Reactions Are So Good Yahoo Entertainment
  6. View Full Coverage on Google News

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Rare but deadly fungal infection Valley Fever is spreading fast ‘because of climate change’

A deadly fungal infection is spreading across the US — and scientists believe it is due to climate change.

Cases of ‘Valley Fever’ – which is 10 times more deadly than flu – have risen 20-fold since the turn of the century.  

It is caused by the fungus Coccidioides, which releases spores in the air when soil is disturbed. The spores are then inhaled by people, most commonly construction workers.

The fungus thrives in warm, dry environments and was dubbed Valley Fever because 97 percent of cases are found in Arizona and California. But infections have begun to crop up in other parts of the country, and experts fear that by 2100 it could be endemic in 17 states.

It comes amid heightened fears about fungal outbreaks, following the hit apocalyptic HBO show ‘The Last of Us,’ which depicts a fungus that turns victims into zombies. 

The fungus spore is whipped up into the air when the soil is disturbed by the wind or digging. When humans or animals breathe in the spores, they travel through the respiratory tract and into the lungs where they reproduce

The infection was dubbed Valley Fever because 97 percent of cases are found in Arizona and California

While Valley Fever cannot turn the host into a zombie, it can cause serious harm to some sufferers, and kills one in 100 who contract the infection.

Coccidioidomycosis or cocci originates from a fungus that grows in the soil in some areas of California and southwestern US.

The fungus spore is whipped up into the air when the soil is disturbed by the wind or digging. 

When humans or animals breathe in the spores, they travel through the respiratory tract and into the lungs, where they reproduce, causing further disease.

Most infections are mild and clear up on their own within a few days or weeks, and the infection cannot be passed between people or animals. 

Most people who have the mild form of infection will not realize because its symptoms  — fatigue, cough, fever, aching muscles and breathlessness — mimic those of a respiratory virus infection.

Other symptoms include night sweats, joint aches and a red rash, usually on the legs but occasionally on the chest, arms and back. 

But up to ten percent of cases become severe and take months to recover from.

In these cases, known as disseminated coccidioidomycosis, the disease can spread through the bloodstream to other parts of the body, including the brain, skin and liver. If it infects the membranes and fluid around the brain, it can cause meningitis.

‘The Last of Us’ follows smuggler Joel (right) as he escorts teenager Ellie (left) through Boston, Massachusetts, while a fungus spreads across the world

‘The Last of Us’ is set in a world where a fungus is spreading that turns victims into zombies called ‘Clickers’ (pictured)

According to the Centers for Disease Control and Prevention (CDC), roughly 20,000 cases of Valley Fever were reported in 2019.

It said this is probably an underestimate, as Valley Fever has been frequently misdiagnosed because doctors do not know enough about it, so patients are not even tested for it.

The fungus is endemic to the desert-like parts of the Southwest, and 97 percent of all American cases are found in Arizona and California. 

But a study in the journal GeoHealth predicted that, due to climate change, the endemic region of the fungus will spread north to include dry western states such as Idaho, Wyoming, Montana, Nebraska, South Dakota, and North Dakota.

In a high-warming scenario, this would mean that by 2100 the number of affected states could rise from 12 to 17, while the number of cases could increase by 50 percent.

In October last year, the World Health Organization (WHO) released the first ever list of fungal pathogens that pose a risk to human health.

Dr Hanan Balkhy, assistant director-general for antimicrobial resistance at WHO, said: ‘Emerging from the shadows of the bacterial antimicrobial resistance pandemic, fungal infections are growing, and are ever more resistant to treatments, becoming a public health concern worldwide.’

Valley fever is already tricky to treat, and there is no vaccine for it. Patients might have to take antifungal medication for months and endure unpleasant side effects such as hair loss and scaly skin.

Scientists have been trying to formulate a Valley Fever vaccine for decades, but a shot tested in humans in the 1980s did not perform well.

In the past few years, scientists from the University of Arizona College of Medicine in Tucson have created a vaccine that works in dogs, who are also at risk of the infection.

The US Department of Agriculture could approve the shot for canines by early 2024, which would be the first one to protect against a fungal infection in humans or animals in America.

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What are the most common COVID symptoms now? It’s no longer fever, loss of taste

Health officials are warning about a holiday “tripledemic” – a combination of COVID-19, flu and Respiratory syncytial virus, or RSV – that is filling up hospitals and prompting the Centers for Disease Control to advise many people to go back into masks.

And, with Christmas and New Year’s set for later this month, the numbers, particularly those of COVID-19 cases, are likely to keep climbing.

The latest CDC numbers from Dec. 8 show just under 14% of Americans now live in communities rated as having “high” COVID-19 community levels, up from 4.9 percent the previous week. Another 38% of Americans are in a “medium” areas and 48% are in “low” areas.

READ MORE: Alabama COVID hospitalizations on the rise again after Thanksgiving

What are the most current COVID-19 symptoms?

The symptoms of COVID-19 have changed as the virus has developed new variant and adjusted to vaccines. According to a report in The Hill, the new symptoms are tied to new dominant subvariants – BQ.1 and BQ.1.1 – that now comprise the majority of cases in the U.S.

The ZOE Health Study, a joint effort by researchers at Massachusetts General Hospital, the Harvard T.H. Chan School of Public Health, King’s College London, Stanford University School of Medicine, and the health app ZOE, has tracked symptoms of the virus as they have changed.

“Since the start of the pandemic, ZOE has continually reported the most common COVID symptoms and how they’ve changed over time. These symptoms have changed for a few reasons, including the introduction of vaccines and the emergence of new variants,” the company said in a statement. “Like every virus, the SARS-CoV-2 coronavirus that causes COVID-19 is constantly evolving, in terms of its ability to spread and the symptoms it causes.”

In October, ZOE said the five most commonly reported symptoms were sore throat, runny nose, persistent cough and headache.

Since then, a headache has become less prevalent but still remains in the top 10. Instead, patients are more likely to experience a blocked nose, sneezing or “a cough without phlegm.”

According to ZOE, these are the top 10 reported COVID symptoms in the last 30 days:

  • Sore throat
  • Runny nose
  • Blocked nose
  • Sneezing
  • Coughing without phlegm
  • Headache
  • Coughing with phlegm
  • Hoarse voice
  • Muscle aches and pains
  • Altered sense of smell

All of these symptoms have been listed as COVID side effects since the start of the pandemic in March 2020. Missing from the latest list, however, were gastrointestinal-related symptoms such as diarrhea, nausea or vomiting as well as some of the earlier hallmarks of the virus – loss of sense of taste, shortness of breath and fever.

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The Mercedes-Benz Vision AVTR is a futuristic fever dream that’s hilariously nerve-racking to drive

Lightstorm Entertainment is a place where mind-boggling sights have become somewhat commonplace. James Cameron’s California-based company has produced nearly all of the director’s films since 1990, from Terminator 2 to The Abyss to Titanic and, most notably, 2009’s groundbreaking Avatar and its sequel Avatar: The Way of Water, which releases in theaters on December 16th.

In addition to offices, massive sound stages, and rooms filled with computers doing visual effects work, there’s a museum room featuring props like the Alien queen from Aliens, a Terminator from T2, 1:8-scale Titanic models and the actual Heart of the Ocean necklace. Walking through is mind-blowing stuff, but it’s just another Thursday at work for these artists.

But on this chilly November afternoon, employees walking around the studio lot are stopping dead in their tracks, jaws agape, and cellphone cameras at the ready. A real-life spaceship has touched down in Manhattan Beach, and it’s crabwalking around the parking lot.

This neon-lit chrome egg is the Mercedes-Benz Vision AVTR, a concept car first revealed at CES 2020 as a tie-in with the Avatar franchise that has been trotted out to a handful of auto shows and events since. With the sequel finally upon us nearly three years later, Mercedes got together with the film’s producers to showcase the car again, this time to a handful of journalists as part of promotion for the new movie.

A real-life spaceship has touched down in Manhattan Beach

Before interacting with the car, we sat down in the Lightstorm private screening room’s plush recliners to hop on a Zoom call with Gorden Wagener, who has been chief design officer of Mercedes-Benz, and Jon Landau, the Oscar-winning producer of Titanic and the Avatar movies. Sadly, we weren’t provided with any popcorn, but Landau and Wagener discussed how this strange partnership came to be and why it actually makes sense for both brands.

The project first started in 2018, about a year after the start of production on The Way of Water. Mercedes’ automotive designers worked with the production designers creating Pandora’s creatures, environments, sets, and effects, with both teams visiting each others’ studios in Germany and California. Mercedes saw thousands of designs from Weta FX, which is doing all of the visual effects work for the new movie, and Landau describes it as a very iterative process. Wagener and Landau joke about how a car’s design is frozen years before its release, but a movie isn’t done until the night of the premiere, so Mercedes got to witness many stages of the film’s production.

Why Avatar, though? The team was looking for partners to share in the franchise’s uncommon ethos that, in Landau’s words, “challenges us to look at our world a little bit differently, to understand that our actions have an impact on the people and world around us.” Both Landau and Wagener exclaim how the initial idea felt like a dream coming true, with Wagener saying that both brands share a common goal — and “a common responsibility, as a car maker,” he adds — of making the world a better place.

The Vision AVTR’s design was inspired by the nature of Pandora, the planet on which Avatar takes place, which Wagener says ties in perfectly with Mercedes-Benz’s design language. “Whatever we do is going to be beautiful,” says Wagener. He describes a form-follows-function approach in the way of architect Andrew Sullivan that’s more about “the awe of nature and the beauty of creation.”

On Pandora, the Na’vi ride incredible flying creatures called banshees, which provided an inspiration for the AVTR’s overall shape. The spherical wheels look bonkers, with the illuminated sections echoing the woodsprites from Pandora’s sacred tree. Thirty-three individually controlled flaps on the rear move organically as the AVTR drives, like gills or bristling wings.

The Vision AVTR’s design was inspired by the nature of Pandora, the planet on which Avatar takes place

Landau insisted on the AVTR having doors so the occupants are protected, and the way the huge glass panels open was taken from the motion of the banshee’s wings. Pandora is covered in bioluminescent fauna, so the AVTR’s cabin is full of radical lighting. There are a few elements present on the AVTR that made their way to Mercedes’ EQ production models, though, like its overall one-bow silhouette, slim head- and taillights and the large faux grille panel.

Maybe the funniest part of this collaboration is that the Vision AVTR won’t actually be in the new movie. All of the human machines we see on Pandora are brutalist, destructive military vehicles that destroy the planet’s ecosystem at the behest of human corporations, and as Wagener says, “we didn’t want it to be the bad guy.”

The Vision AVTR was thus designed to look like it would fit in with the world of Pandora instead of being a vision of what a car in the movie’s universe would actually be. (The Avatar and Mercedes folks stop ahead of confirming whether or not cars, and Mercedes itself, still exist at all in the 22nd century when the movie takes place.) But the AVTR exists here on our real Earth, and it’s my turn to drive it.

Maybe the funniest part of this collaboration is that the Vision AVTR won’t actually be in the new movie.

In Avatar, the Na’vi use their hair braids to make symbiotic brain connections with creatures on Pandora, and the Vision AVTR is turned on in a similar sort of way. Place your hand on the center console, and the AVTR literally pulses to life. The car’s spatial audio speakers play the thump of a heartbeat, eight exciters in the seats vibrate in sync, and ambient lighting fluctuates around the cabin.

A strange oval-shaped joystick rises up accordion-style from the center console and begins to pulse, too — that’s how the AVTR is actually controlled. There’s no steering wheel or pedals here, and the AVTR can be driven from either front seat. You push the joystick forward or back to accelerate or brake and tilt it to either side to turn or twist the top of the controller to crabwalk. The driving position is laid back, with cocoon-style seats and huge expanses of glass from the windshield and doors providing a great view out.

While most concept cars are usually remote-controlled and powered by tiny electric motors with single-digit top speeds, the Vision AVTR will do 35 mph. But that doesn’t mean it’s built like a normal car. The AVTR is obviously hand-built and very fragile.

On the move, it’s rickety and noisy and cold, with basically zero suspension or interior insulation, and a couple of the interior trim pieces are broken. The Mercedes employee conducting the drives has a custom iPhone app that can control the lights, interior functions, rear flaps and other bits from outside the car. Mercedes has said the AVTR has a 110kWh battery pack and four electric motors, with each wheel being able to be independently driven.

The AVTR is obviously hand-built and very fragile

After being driven around part of the lot, I get to take control. Even disregarding the fact that I’m sitting on the right side of the car, driving the AVTR is a strange experience. It employs the same joystick technology used for drivers with disabilities, and the control is sensitive and hard to modulate. If you press it forward and take your hand away, the AVTR will keep driving forward until the stick is reset at that same speed. Multiple times, I find myself accidentally crabwalking toward a parked car instead of turning normally, and it’s tough to make minor corrections.

The rear-wheel steering gives the AVTR a tight turning radius, while the crabwalking can be done at an angle of up to 30 degrees, so it doesn’t maneuver like a normal car, either. It feels ridiculous and eerie from inside the car but looks even more bizarre to the people around us.

I also don’t get to try out the AVTR’s infotainment system while driving, but I’m given a demo of how it works when the car is static. The entirety of the Y-shaped dashboard functions as a display through projection, and it shows the landscape on Pandora. Raise your hand, and menus are projected onto your palm, using gestures to make selections and control different functions. While parked, you can use the display to take a virtual tour of Pandora or one of three wonders of the natural world: the Huangshan Mountains in China, the Hyperion tree in the US, and Lake Hillier in Australia. It all works pretty well.

My time with the AVTR is short, and then it’s on to the next person, but I stick around so I can keep watching the UFO drive around as Mercedes continues giving rides around the lot to employees from Lightstorm and Disney. A security guard on a golf cart has served as a pace car for the Vision AVTR all day, making sure the path ahead is clear and no cars inadvertently cut off the multimillion-dollar concept car, so I hop on the back to really witness the AVTR in motion.

As the evening progresses and darkness falls, the AVTR reaches its maximum absurdity level. The ground is bathed in blue light from the wheels as the AVTR glides around, its actuated flaps making small automatic adjustments when the car starts moving sideways. 

When touring Lightstorm’s museum, I’m told how James Cameron doesn’t make science fiction — he creates science fact. In all of his movies, everything from the creatures to the machines has to work, or it has to be engineered and designed so it would work in the fictional world of the movie. Before anything is done on a computer, the artists make real-life scale models that are then scanned and digitally created so Cameron can view and modify them in 3D.

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This technique is even used in the Avatar franchise, which continues to be a pioneer in the realms of motion capture and CGI — for instance, a life-size silicone bust of Neytiri greets those who enter the room, and the massive mech featured in the first film’s climax was built for real and actually works. 

The technology in the Vision AVTR isn’t as outlandish as it may seem, either. The production EQS has 10-degree rear steering, which, while not as dramatic as the AVTR’s, is still spectacular to witness and use, and crabwalking is a standard feature on the Hummer EV. The EQS also has AVTR-inspired features like wild ambient lighting, a full-width dashboard display and gesture controls. Even the most fantastical concept cars like this one can still preview design ideas and potential technologies that could be found on future production cars, all while letting the designers have some fun that’s free of pesky regulations.

Even the most fantastical concept cars like this one can still preview design ideas and potential technologies

Mercedes-Benz was the second-best-selling luxury car brand in the US last year, being barely edged out for the top spot by BMW. Meanwhile, Avatar: The Way of Water is a follow-up to what remains the highest-grossing movie of all time, with the original having made nearly $ 3 billion since 2009 — including more than $75 million from a recent, one-week-only IMAX rerelease.

There are huge expectations for the new movie — Cameron says it needs to make at least $2 billion just to break even — and just like with T2, Titanic, and the first Avatar, there have been sensational stories from Hollywood insiders ahead of the release talking about how much of a flop The Way of Water will be. The Vision AVTR is a headline-generating marketing tool, bringing an enormous number of eyes to both brands.

But it’s not about the money, really. Cynical as the sustainability and brand synergy messaging might seem, it’s a genuine effort for both parties. Cameron has been a climate change activist for decades, with Avatar serving as an allegory for the dangers facing our Earth. By 2039, Mercedes aims to have a carbon-neutral fleet and will exclusively sell electric cars by 2030 in most markets.

The Vision AVTR uses recycled materials made from old clothes and plastic bottles, vegan Dinamica microfiber and sustainably cultivated Karuun rattan wood. Mercedes’ production EQ cars are increasingly being made with many similar sustainable materials, with the EQS using 176 pounds of recycled and renewable materials in its manufacturing. “We share the belief that we need a more respectful approach to nature,” says Mercedes CEO Ola Källenius, calling Avatar a source of inspiration.

Landau says that when he saw the Vision AVTR at CES in 2020, he didn’t pay attention to it. Instead, like he does at movie premieres, he was watching the audience’s reaction, which he calls the true art form. The AVTR debuted to a crowd of 4,000 people, and Landau says that “there could be nothing more rewarding than the response we got.” Wagener agrees, calling the AVTR’s reveal one of the best shows that Mercedes has ever put on. “I think the Vision AVTR is one of the strongest statements we’ve ever made,” says Wagener, noting that he’s especially proud of bringing elements of it to production with the EQS.

The Vision AVTR will be present on the blue carpet for The Way of Water’s Hollywood premiere on December 12th, the audience response to which Landau will surely be intensely watching. To go along with the release of the movie, Mercedes is launching a new Avatar-themed ad campaign for its EQE SUV.

The short commercial shows a woman seemingly on Pandora, walking around a jungle and swimming in the ocean before coming out of her dream and driving off in the EQE, declaring that “Earth is our Pandora.” It’s silly, yes, but if it gets more people to consider the impact that the automotive industry has on our planet, it’s done its job. 

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Queues form at fever clinics as China wrestles with COVID surge

  • Queues outside fever clinics in Beijing, Wuhan
  • Top virus expert says peak may come in a month
  • Stocks, yuan sag on concern over rising cases
  • China moves to free up domestic travel

BEIJING/HONG KONG, Dec 12 (Reuters) – People queued outside fever clinics at China’s hospitals for COVID-19 checks on Monday, a new sign of the rapid spread of symptoms after authorities began dismantling stringent curbs on movement.

Three years into the pandemic, China is moving to align with a world that has largely opened up to live with COVID, making a major policy change last Wednesday after unprecedented protests.

It has dropped testing prior to many activities, reined in quarantine and was preparing to de-activate a mobile app used to track the travel histories of a population of 1.4 billion people.

Authorities continue to urge mask-wearing and vaccinations, particularly for the elderly.

But with little exposure to a disease kept largely in check until now, China is ill-prepared, analysts say, for a wave in infections that could heap pressure on its fragile health system and drive businesses to a halt.

Lily Li, who works at a toy company in the southern manufacturing hub of Guangzhou, said several employees, as well as staff at suppliers and distributors, had been infected and were at home isolating.

“Basically everybody is now simultaneously rushing to buy rapid antigen test kits but has also somewhat given up on the hope that COVID can be contained,” she said.

“We have accepted that we will have to get COVID at some point anyway.”

In Beijing, about 80 people huddled in the cold outside a fever clinic in the upmarket district of Chaoyang as ambulances zipped past.

A Beijing government official said on Monday night that visits to such clinics has risen to 22,000 per day, up 16 times on the previous week.

Reuters witnessed similar queues outside clinics in the central city of Wuhan, where COVID-19 first emerged three years ago. read more

In recent weeks, local cases have been trending lower since a late November peak of 40,052, official figures show, however. Sunday’s tally of 8,626 was down from 10,597 new cases the previous day.

But the figures reflect the dropping of testing requirements, say analysts, while health experts have warned of an imminent surge.

In comments on Monday in the state-backed newspaper Shanghai Securities News, Zhang Wenhong, head of a team of experts in the commercial hub, said the current outbreak could peak in a month, though an end to the pandemic might be three to six months away.

In a WeChat post, Zhang’s team said that despite the surge, the current Omicron strain did not cause long-term damage and people should be optimistic.

“We are about to walk out of the tunnel; air, sunshine, free travel, all waiting for us,” the post said.

STOCKS, YUAN SAG

China’s stock markets broadly retreated and the yuan eased from a near three-month high hit in the previous session, as investors fretted that rising infections might disrupt consumption and manufacturing.

But for the same reason, demand surged for stocks in Chinese drugmakers and providers of masks, antigen tests and funeral services.

“Please protect yourself,” the management of a condominium in the capital’s Dongcheng district warned residents on Sunday, saying almost all its staff had been infected.

“Try as much as you can not to go out …,” it said on messaging app WeChat. “Be the first person to take responsibility for your own health, let’s face this together.”

Such messages appear to have hit home for some who say they are reluctant to visit crowded places or dine at restaurants.

That is why few analysts expect a quick, broad rebound in spending in the world’s second largest economy, as the glee that greeted the abrupt relaxations was tempered with uncertainty for consumers and businesses.

Yet China is pushing to free up nationwide travel, even if foreign trips may be a while off.

A state-mandated mobile app identifying travellers to COVID-stricken areas will shut down at midnight on Monday, according to a notice on its official WeChat account.

The number of domestic flights available across China exceeded 7,400, nearly double from a week ago, flight tracker app VariFlight showed.

New home sales in 16 cities picked up last week, in a move partly attributed to the easing of curbs, as people venture out to view homes, the China Index Academy said.

Reporting by Eduardo Baptista, Ryan Woo, Bernard Orr, Sophie Yu in Beijing, Brenda Goh in Shanghai, Martin Quin Pollard in Wuhan and Josh Ye and Greg Torode in Hong Kong; Writing by John Geddie; Editing by Clarence Fernandez and Nick Macfie

Our Standards: The Thomson Reuters Trust Principles.

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Scarlet fever is soaring in UK after pandemic lull; invasive infections kill 8

Streptococcus pyogenes, a common type of group A strep. “/>
Enlarge / A microscope image of Streptococcus pyogenes, a common type of group A strep.

Scarlet fever is spiking in the UK, with case numbers more than fourfold higher than normal for this time of year. And a rare but serious invasive disease caused by the same bacteria that causes scarlet fever and strep throat—Group A streptococci—is also surging, killing at least eight children in the UK, according to media reports.

The unusual rise is seen as yet another anomalous disease transmission cycle rippling in the wake of the COVID-19 pandemic. Like many other seasonal infections, scarlet fever cases in the UK virtually flattened at the end of the 2019–2020 season and bottomed the chart throughout the 2020–2021 season, according to data released by the UK Health Security Agency.

Now, with most pandemic-related health restrictions lifted or at least eased, a throng of seasonal infections—particularly those that hit children the hardest—have returned. Many have returned with some ferociousness, finding a yet larger pool of susceptible victims than usual after a hiatus. Many of these disease-cycle anomalies have been seen in seasonal viruses, namely enteroviruses, adenoviruses, influenza, and RSV (respiratory syncytial (sin-SISH-uhl) virus), which are currently swamping hospitals and pediatric wards in the US.

“Lots of infections became rarer during the restrictions of the recent pandemic and are now coming back rapidly as mixing normalizes,” Adam Finn, a pediatrics professor at the University of Bristol, said in a statement. “[Group A strep] is no exception, and we have been seeing increasing numbers of cases in recent months.”

Infection connections

Transmission of group A strep bacteria is associated with the transmission of viruses. Historically, group A strep infections are closely linked to the spread of chickenpox, though clinicians note that a strep infection can strike after other viral infections. It’s unclear what the link between certain viral infections and group A strep is exactly. Researchers have hypothesized a confluence of factors may explain the link, from overlapping timing in disease cycling, similar transmission routes (e.g., respiratory), and the common age of victims.

There’s also the possibility that some germs share common methods of suppressing the immune system to spark an infection. Thus, infection with one germ could pave the way for another that takes a similar route. There is some evidence for this with chickenpox and group A strep, which similarly alter the activity of certain T cells. But some viral infections also suppress the immune system more generally. Perhaps the best example of this is measles, which suppresses immune response for weeks to months after an infection, leading to what some experts call “immune amnesia.” Prior to childhood vaccination campaigns, spread of measles was closely associated with upticks in cases of whooping cough (pertussis), which is caused by the bacterium Bordetella pertussis.

The current rise of group A strep infections in the UK is not clearly linked to a rise in chickenpox cases. Chickenpox is not a notifiable disease in the UK, meaning official counts are unavailable. However, sentinel surveillance data suggests that there hasn’t been an unusual rise.

The rise of strep A is coinciding with viral respiratory infections, though.

“Usually we see a high number of [group A strep] cases in late spring or early summer, often after chickenpox infections,” Elizabeth Whittaker, a pediatric infectious diseases and immunology expert at Imperial College London, said in a statement. “High numbers at this time of year are unusual and probably occurring as normal seasonality has not yet returned… We are seeing more pneumonia than usual, most likely as group A strep infections are coinciding with the peak in winter respiratory viruses which are typical for this time of year.”

Group A strep infections typically cause mild infections such as strep throat, scarlet fever, and the skin infection impetigo, which are effectively treated with antibiotics. In the UK, there were 851 cases of scarlet fever in week 46 of this year (ending on November 19), whereas the average for the previous years was 186 cases in week 46, the UKHSA reported. The spike is part of a larger rise; there were 4,622 notifications of scarlet fever in weeks 37 to 46 this year in England, compared with an average of 1,294 in the same period in the previous five seasons.

Severe cases

In rare cases, group A strep can get into the bloodstream, causing a severe, invasive disease called invasive Group A strep (iGAS), which can be deadly in young children. So far this year, the UKHSA has tallied 2.3 cases per 100,000 children ages 1 to 4 compared with an average of 0.5 in the pre-pandemic seasons (2017 to 2019) and 1.1 cases per 100,000 children ages 5 to 9 compared to the pre-pandemic average of 0.3 at the same time of the year.

Severe cases remain rare, but identifying strep A infections may be more difficult than normal this year as it circulates among respiratory viruses, potentially delaying treatment.

“Severe invasive group A strep is rare, and parents don’t need to worry, but do need to be aware when and how to seek medical attention,” Whittaker said. “We would normally expect fevers due to viral infections to settle within 4 or 5 days, so if they are persisting, or are associated with lethargy, difficulty breathing, poor drinking or wet nappies/urine output, families should get in touch with NHS111 for advice,” referring to a non-emergency medical service line in the UK.

“Prompt treatment with antibiotics can manage these infections, but it is important they are recognized and treated quickly,” Nathalie MacDermott, a pediatric infectious disease expert at King’s College London, said. “Prompt treatment of scarlet fever and strep throat also reduces the chances of a child developing invasive Group A Strep and reduces the chances of the infection spreading to other children at school or household members.”

In the US, scarlet fever is not a notifiable disease—so there are no official numbers—but there is surveillance of iGAS cases. In a press briefing earlier this week, Barbara Mahon, an epidemiologist with the Centers for Disease Control and Prevention, said, “As far as I’m aware, we have not heard of any notable increase [in iGAS cases].”

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