Tag Archives: Fatigue

The futility of Helldivers 2’s ‘Menkent Line’ has parts of the community feeling bot fatigue: ‘We fought hard to establish a defensive line, and for what?’ – PC Gamer

  1. The futility of Helldivers 2’s ‘Menkent Line’ has parts of the community feeling bot fatigue: ‘We fought hard to establish a defensive line, and for what?’ PC Gamer
  2. Chill out, Helldivers 2 hardcores trying to get casual players to stick to the battle plan, Arrowhead’s doing what it can to help out VG247
  3. Helldivers 2 developer warns we’re “intentionally going to lose ground” in this Major Order as both Bots and Bugs want revenge Gamesradar
  4. Helldivers 2 planet liberation isn’t working as intended yet, but Joel will flip the switch PCGamesN
  5. Helldivers 2 dev “looking into” progress tracking and display issues Eurogamer.net

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‘The Marvels’ Tracking for $75M-$80M Domestic Debut in Latest Test of Box Office Superhero Fatigue – Hollywood Reporter

  1. ‘The Marvels’ Tracking for $75M-$80M Domestic Debut in Latest Test of Box Office Superhero Fatigue Hollywood Reporter
  2. ‘The Marvels’ Heading For $75M-$80M Opening; Roughly 50% Lower Than ‘Captain Marvel’ 3-Day – Early Box Office Look Deadline
  3. THE MARVELS’ Final Runtime Has Been Revealed – But Is It Cause For Concern? THE MARVELS’ Final Runtime Has Been Revealed CBM (Comic Book Movie)
  4. The Marvels could take flight with a $75M-$80M opening at the box office JoBlo.com
  5. ‘The Marvels’ May Open to Half the Box Office of ‘Captain Marvel’ ScreenCrush
  6. View Full Coverage on Google News

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‘Trump fatigue’ in New Hampshire complicates 2024 White House bid

By Tim Reid

WEARE, New Hampshire (Reuters) – When Donald Trump trounced his Republican rivals in New Hampshire’s 2016 primary, the stunning win announced to other states the reality TV showman was a serious contender. Trump went on to capture the Republican nomination and then the White House.

But as the former president kicks off his bid to recapture the White House in 2024 with a speech in New Hampshire on Saturday – his first event in an early primary state – he will find the political landscape more treacherous than he did six years ago, according to party activists, members and strategists in the state.

In interviews with 10 New Hampshire Republican Party officials and members, some of whom worked on Trump’s 2016 primary campaign and all of whom have been staunch Trump supporters in the past, Reuters found only three who were sticking with him this time around – including the state chair, an influential Republican figure who is so enthusiastic about Trump he is stepping down on Saturday to help his campaign.

The rest cited exhaustion with Trump’s controversies, exasperation at the constant drama, and a desire to move on from Trump’s loss in 2020 with a fresh face who they thought would have a stronger chance of winning in 2024.

Trump’s campaign did not respond to requests for comment.

The public souring on the former president is a troubling development for Trump. A defeat could complicate his chances of winning the party nomination for president, analysts say, because New Hampshire often gives a candidate momentum as they head to other primary states.

A lack of enthusiasm for the former president and his prospects for winning in 2024 could hurt Trump because party activists do vital groundwork for candidates, such as knocking on doors and making phone calls to raise money and boost turnout.

Most of the New Hampshire party members who had cooled on Trump said they would prefer Florida Governor Ron DeSantis as the party’s standard bearer, although DeSantis has not yet said if he will launch a White House bid.

“Donald Trump right now is a distraction for the Republican Party in trying to go forward. Donald Trump has run his course,” said Brian Sullivan, 60, a Hillsborough County Republican Committee member who backed Trump in the 2016 primary.

“I would rather see someone else, like Ron DeSantis, in the race,” Sullivan said.

While he likes Trump’s policies and applauds his achievements in office, “he’s got so much baggage. I just don’t think he has what it takes to win the White House again,” Sullivan said.

The three Republicans still backing Trump said his voting base in New Hampshire remains enthusiastic, he has formidable name recognition, and that many Republican voters like his policy achievements while in office, giving him a strong record to run on, unlike other potential candidates.

The Trump campaign, in an email to supporters, touted a Jan. 24 poll from Emerson College Polling showing the former president leading DeSantis nationally among Republican voters, 55% to 29%.

Yet the willingness of Republican party members to criticize Trump in conversations with Reuters is striking. Some Republican party officials and members who have broken with Trump in the past have been subjected to blowback and online trolling from his supporters.

Lori Davis, 67, got into grassroots Republican politics because of Trump. Back in 2015 when he announced his candidacy, she was inspired. She worked on his New Hampshire primary campaign, knocked on doors for him, urged anybody she met to vote for him.

Not this time.

“I like Donald Trump. But he has gone too far polarizing. It’s going to be an uphill battle for him in this primary because of his divisiveness. People are tired of the drama,” Davis said at her home over a meal of burgers.

“I’m seeing that people want DeSantis. He has a lot of the Trump philosophy, but is not as bombastic, he’s not attacking people 24/7. People are tired of that. It gives them headaches,” Davis said.

`PEOPLE WANT A WINNER`

It is not just in New Hampshire where Trump faces potential headwinds. Some billionaire donors who helped fund his previous campaigns have not yet donated. They include hedge fund billionaire Robert Mercer and his daughter, Rebekah Mercer. She has already donated to DeSantis’s political committee.

New Hampshire has an outsize role in choosing presidential candidates because it is the second nominating contest after Iowa’s caucuses.

While the winner of New Hampshire’s Republican primary has not won the state in a general election since George W. Bush in 2000, it is still viewed as a critical test in the nominating process.

Chris Maidment, chairman of the Hillsborough County Republican Committee, described the mood among many members as “Trump fatigue,” adding: “I’m definitely open minded this time round. There’s a lot of exciting potential candidates out there.”

A majority of candidates Trump endorsed in competitive races in November’s congressional elections lost to Democrats. During Trump’s four years as president after his 2016 victory over Democrat Hillary Clinton, Republicans lost control of both chambers of Congress, before he lost the 2020 election to his Democratic opponent, Joe Biden.

“People want a winner and the elections are about the future. Republicans want someone who can win and who is not going to be a pushover for the Left. Trump represented that before but I’m not sure he represents that now,” said Neil Levesque, executive director at the New Hampshire Institute of Politics at Saint Anselm College.

In a poll conducted of likely Republican primary voters in New Hampshire by Levesque just before last November’s election, Trump trailed DeSantis by 38% to 47%. Overall, 50% of the state’s voters had a “strongly unfavorable” impression of Trump, with just 22% a “strongly favorable” one.

Another complicating factor for Trump this time round is that independents can vote in New Hampshire’s Republican and Democratic primaries. If Biden runs again, the Democratic primary will likely be uncontested, and many independents may choose to vote in the Republican primary where their vote will have a bigger impact.

“Independents go where the action is. A lot of independents will vote against Trump. And that’s not good news for him”, Tom Rath, a Republican strategist in New Hampshire, said.

Polls in New Hampshire and elsewhere show Trump is unpopular with a majority of independents.

Despite signs of weariness with Trump, he will still be a formidable candidate in the New Hampshire primary, some party strategists said.

“He still starts 2023 as the frontrunner. He’s got name ID, a strong base of supporters. His influence is still fairly significant,” said Jim Merrill, a veteran New Hampshire Republican strategist.

Trump is the only Republican to declare his candidacy so far, although it is likely the field of rivals will grow this year. Others expected to jump into the race include DeSantis, Trump’s former vice president, Mike Pence, and Nikki Haley, the former South Carolina governor.

STICKING WITH THE REAL DEAL

For Steve Stepanek, a former state representative who was the first elected official in New Hampshire to endorse Trump in 2015 and is chairman of New Hampshire’s Republican Party, those potential contenders would be pale imitations of the real thing.

He remains a staunch supporter of the former president and is about to step down as the party chair because he wants to be involved with Trump’s latest campaign, he told Reuters.

A replacement will be elected at a party meeting on Saturday, where Trump will be the keynote speaker. It is not yet clear if Stepanek’s departure will loosen Trump’s grip on the party machinery.

Stepanek accused the Republican Party naysayers of being Republican insiders, not the ordinary voters who decide primary elections.

“Are you going to believe a candidate who says I’ll continue the Trump policies – or the man who is the Trump policies?”

(Reporting by Tim Reid in Weare, New Hampshire; Editing by Ross Colvin and Suzanne Goldenberg)

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Cancer symptoms: Almost everyone with advanced cancer experience ‘unbearable’ fatigue

The severity of cancer symptoms intensifies as the disease progresses, yet many patients ignore them until they become unbearable. Unfortunately, failure to report symptoms early significantly worsens the prognosis of cancer. Reports state that most patients diagnosed in the advanced stages report the same debilitating symptom.

The American Cancer Society explains: “Fatigue is the feeling of being tired and not being able to do things at your usual pace.

“This tiredness can affect you physically, mentally and emotionally.”

Those cancer patients afflicted by this symptom often describe an ongoing sense of extreme tiredness that does get better with rest.

“Almost everyone with advanced cancer has this symptom,” adds the health body.

READ MORE: Side effects of popular supplement could include cancer

When advanced cancer is diagnosed it is unlikely to be cured or controlled efficiently with treatment.

This is because the tumour will have invaded nearby tissue, lymph nodes and other distant parts of the body.

Treatment may still be administered in a bid to shrink the tumour, but sometimes doctors decide the risks of treatment outweigh the benefits.

It should be noted that people with advanced cancer are more likely to experience fatigue than those patients in the earlier stages of the disease.

DON’T MISS: 

The main cause of fatigue in cancer patients is disruptions to the body’s hormone levels, which is often seen in diseases like breast and prostate cancer.

Once there is a higher number of cancer cells in the body, fatigue may lead to decreased eating, and decreased activity.

Cancer Research UK adds: “Some cancers make substances called cytokines.

“Cytokines are a group of proteins in the body that play an important part in boosting the immune system. These can cause fatigue.”

READ MORE: UK scientists make potential breakthrough in breast cancer treatment

A report published in the medical journal BMC Primary Care characterised the type of fatigue in patients with terminal cancer as an ‘unbearable weakness’.

The report states that “weakness was the more frequent unbearable symptom”, seen in 57 percent of patients receiving palliative care.

The Cleveland Clinic describes cancer fatigue as “paralysing”, as it may come on suddenly.

The health body adds: “With this type of fatigue, no amount of sleep or sleep helps.

“You feel physically, emotionally and mentally exhausted most of the time.”

The American Cancer Society adds that patients often describe the fatigue as feeling “listless, drained or washed out” that may decrease for a while but then comes back.

Alongside weakness, patients frequently report “unbearable pain”, as per the report in BMC Primary Care.

Pain in terminally ill patients is often characterised as chronic because it tends to last longer than the pain caused by other problems.

In cancer patients, pain often leads to several other complications such as:

  • Feeling irritable
  • Sleeping poorly
  • Decreasing appetite
  • Decreasing concentration.



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Worrying signs that your fatty liver is getting worse | Health

Fatty liver often appears harmless and has rarely any symptoms in the initial stages. It all starts with a build-up of fat in liver that is not broken down properly due to consuming too many calories or diseases like diabetes, high cholesterol among others. In the initial stages, there is hardly any inflammation of damage to the liver and many people may not reach advanced stages of fatty liver disease where the risks of liver cirrhosis and liver cancer goes up. Fatty liver in many people goes undiagnosed in the early stages because it’s most asymptomatic. However, as the disease progresses one may start to notice yellowing of skin, dull ache in the lower right side of the ribs, swelling in abdomen, legs, weight loss among many other symptoms. (Also read: 8 fruits you must eat to reverse fatty liver disease)

“Fatty liver is on the rise due to lifestyle and diet changes. A sedentary lifestyle and excess intake of processed and high-calorie diet are some of the major causes of this condition. Though alcohol tops the chart as an etiology for fatty liver, non-alcoholic fatty liver is equally on the rise due to this,” says Dr Amol Dahale, Consultant, Gastroenterology, Manipal Hospitals, Baner-Pune.

“Mostly detected in asymptomatic patients, few people can develop symptoms like upper abdominal pain, nausea, fatigue, decreased appetite even jaundice in a few cases. Though look benign initially, few people develop cirrhosis and even liver cancer which can be fatal,” says Dr Dahale.

Dr. Pratik Tibdewal, Consultant Gastroenterologist, Wockhardt Hospitals, Mira Road explains in detail the four stages of fatty liver disease and when should one start worrying.

FIRST STAGE: NO RED FLAGS

There are four stages of Non-Alcoholic Fatty Liver Disease (NAFLD) which determine the progression of the disease. The first stage is simple fatty liver or steatosis. This happens when the liver cells start to build-up fat, but without inflammation or scarring at this stage. There are no red flags in this stage and a large number of people don’t even know they have fatty liver. Not everyone with fatty liver will get non-alcoholic steatohepatitis (NASH) which is the second stage.

SECOND STAGE: INFLAMMATION

The second stage of NAFLD is non-alcoholic steatohepatitis (NASH). Here, there is a build-up of fat in the liver cells along with inflammation as the liver is repairing damaged tissue. If the damaged tissue is more then there can be scarring of the liver leading to fibrosis

THIRD STAGE: FIBROSIS

The third stage of NAFLD is fibrosis. It is seen when the scar tissue is there in the liver and in the blood vessels around the liver. Thus, treating inflammation may prevent further progression or even reverse some of the damage. However, if not tackled at the right time, it can lead to cirrhosis.

FOURTH STAGE: CIRRHOSIS

The fourth stage of NAFLD is cirrhosis. At this stage, the liver will completely stop working and there can be signs and symptoms such as yellowing of the skin and a dull ache in the lower right side of the ribs and one will suffer from liver damage which can lead to Ascites (abnormal swelling), leg swelling, bleeding from vomiting or altered consciousness which will require hospitalisation and may require a liver transplantation.

Dr Shankar Zanwar Consultant Gastroenterologist, Wockhardt Hospital, Mumbai Central shares fatty liver danger signs that nobody should ignore.

– If the patient starts getting fatigue in activities which are not usually tiresome

– Loss of desire to eat food

– Yellowish discolouration of eyes and urine

– Fullness of abdomen typically due to fluid accumulation

– Blood vomiting

– Black coloured stools

– Leg swelling

– Weight loss

– Abnormal mental activity in form of disturbed sleep and wake cycle, irrelevant talking, disorientation

– Easy bruisability meaning bleeding under skin with trivial injuries

“As the dictum goes that prevention is better than cure, early diagnosis and treatment can lead to a complete reversal of the disease. Today with the availability of multiple detection tools like ultrasound, fibro scan, blood tests, early diagnosis is possible. Regular exercise, dietary and lifestyle changes along with medicines can help us to cure fatty liver,” says Dr Dahale.

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The UK’s growing burden of long-COVID

A recent study published in the International Forum of Allergy and Rhinology discusses ear, nose, and throat (ENT)-related post-acute symptoms of the coronavirus disease 2019 (COVID-19), of which include vertigo, dyspnea, anosmia, ageusia, and sore throat. Furthermore, post-acute or long COVID symptoms were found to be more common in females and White identifying individuals between the ages of 35-49 years, as well as the disabled.

Study: The growing burden of Long Covid in the United Kingdom: Insights from the UK coronavirus infection survey. Image Credit: Darren Baker / Shutterstock.com

Background

Long COVID refers to prolonged symptoms that persist for more than 12 weeks after recovery from infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several long COVID symptoms have been reported, some of which include headache, myalgia, fatigue, as well as loss of taste and smell. Additionally, parosmia, brain fog, and memory loss have been reported to persist for several months after the initial infection.

Current estimates indicate that long COVID currently affects between 3% and 12% of the population in the United Kingdom. Although post-viral syndromes are widely documented following other types of infection, the scale of long COVID, combined with the rapid spread of SARS-CoV-2, necessitates a better understanding of the epidemiology and risk factors of this syndrome.

The COVID-19 Infection Survey (CIS) is the largest regular survey of COVID-19 and provides essential information to assist the U.K. in response to the pandemic. As a part of the survey, the government was informed on how many people tested positive for COVID-19 in England, Wales, Northern Ireland, and Scotland. This information was subsequently used to assist in decision-making for healthcare policies and public awareness. 

About the study

The current study examines the prevalence of ENT-related symptoms of long COVID and aimed to identify demographic groups at greatest risk for long COVID.

In a longitudinal follow-up program involving patients identified through repeated cross-sectional national surveys, a random sample of volunteers residing in private households was selected. The participants selected were aged two years or older. Children under the age of 12 were surveyed by their parents and caregivers. 

The responses were analyzed between March 6, 2022, and April 3, 2022. The presence of COVID-19 was confirmed by sampling and testing nose and throat swabs, as well as blood tests.

Patients exhibiting COVID-19 symptoms were asked about their symptoms and how their general well-being was affected by the disease on a daily basis. 

Self-reported long COVID syndrome was defined as symptoms persisting for more than four weeks after the first suspected SARS-CoV-2 infection, without being explained by any other factor. With adjustments for age, sex, and region, Bayesian multilevel regression post-stratification was used for the final analysis.

Study findings

ENT-related long COVID symptoms identified in this investigation included vertigo, anosmia, dyspnea, ageusia, and sore throat. The most prevalent complaint was fatigue, while other common symptoms included vertigo, wheezing, rhinorrhea, sneezing, dyspnea, loss of smell, loss of taste, and sore throat. 

Adults aged 35-49 years of White ethnic background had the highest estimated prevalence of self-reported long COVID at 4.13%.  Women had a greater estimated predilection for long COVID than men at 3.20% and 2.34%, respectively.

Conclusions

The current study was based on a large and weighted sample of participants and a longitudinal follow-up period, which contributed to the strength of the study. The study findings indicate that future policies should focus on identifying and aiding the most vulnerable groups in the U.K. by increasing access to treatments for chemosensory disorders and COVID clinics.

However, the likelihood of confounding results could not be ruled out due to the lack of response or follow-up dropouts that impeded validation of long COVID. Furthermore, the prevalence of post-COVID syndrome could have been overestimated by including symptoms only after four weeks after the infection confirmation. 

Additionally, the survey relied on self-reporting. Specific data confirming a connection between rhinorrhea, sneezing, and wheezing symptoms and the individual COVID variants were not available for this analysis.

Journal reference:

  • Gokani, S. A., Ta, N. H., Espehana, A., et al. (2022). The growing burden of Long Covid in the United Kingdom: Insights from the UK coronavirus infection survey. International Forum of Allergy & Rhinology. doi:10.1002/alr.23103

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Vaccine fatigue is leaving the US vulnerable to flu



CNN
 — 

The flu season ramped up early in the United States this year, but vaccination rates are far from keeping pace.

Flu vaccines are always a tough sell for Americans. The US Department of Health and Human Services set a target vaccination rate of 70% in the Healthy People 2030 plan. But less than half of the population has actually gotten their annual flu shot each year for at least the past decade.

Public health leaders say it has been especially challenging to get people to get their flu vaccine this year because they’re growing tired of hearing about shots.

What once was an annual push to get people vaccinated at the start of each flu season has become near-constant messaging about vaccines, with an announcement about new Covid-19 vaccine availability or eligibility seeming to come every couple of months.

“There’s a great deal of vaccine fatigue out there. Asking people this year to get not just one vaccine but to get the annual influenza vaccine, as well as the Covid booster, has really been what I have called a hard sell,” said Dr. William Schaffner, medical director of the National Foundation for Infectious Diseases and professor at Vanderbilt University Medical Center.

“There’s the old saying, ‘familiarity breeds contempt.’ Well, perhaps that’s a bit strong, but familiarity does seem to breed a certain nonchalance,” he said.

Millions fewer flu vaccine doses have been distributed this season compared with this point in seasons past, according to data from the US Centers for Disease Control and Prevention. Just 26% of adults had gotten their flu shot by the end of October, a deadline that medical experts have long encouraged for optimal protection throughout the season. About 43% of children had gotten their flu shot by the end of November.

The first year of the Covid-19 pandemic – the 2020-21 flu season – was a notable outlier, experts say.

Flu vaccination rates soared higher than usual amid fears of a “twindemic,” with the coronavirus and flu circulating together.

“The public health message – and I think we did it very effectively – was, you can’t protect yourself against Covid right now, but you can definitely take flu off the table,” said LJ Tan, chief strategy officer for the Immunization Action Coalition and co-chair of the National Adult and Influenza Immunization Summit, nonprofits dedicated to improving vaccination coverage in the US.

“We were coming out of lockdowns, and people wanted to be active as opposed to passive. So when we told people at that time, ‘You don’t have a Covid vaccine, but you can certainly take flu off the table by getting a flu vaccine,’ people said, ‘Yeah, I’m doing that.’ “

But that double threat didn’t materialize. Flu seasons have been uncharacteristically mild for the past two years, and people have let their guard down, experts say.

“I’ve almost had to remind people about influenza,” Schaffner said. “We’ve had two quite curtailed, very low influenza years. And of course, everyone’s been preoccupied with Covid, and they want to put Covid behind them and get on with their lives.”

Now, continued messaging about a triple threat of viruses – flu, Covid and RSV – isn’t hitting in quite the same way. The urgency is real, as hospitals across the country stretch their capacity to record levels, but it’s not driving people to action.

“It strikes me that people have gotten used to bad flu seasons for the elderly. So this is kind of just the same, with a few other viruses around. There’s a sense that this is what we’re going to expect and this is what we have to live with,” said Dr. Jesse Hackell, a pediatrician who co-authored a clinical report about countering vaccine hesitancy in 2016.

“What we’re missing is the fact that kids and children’s hospitals are suffering in ways that we’ve never seen before.”

Numerous studies have found that flu and Covid-19 vaccines significantly reduce the risk of severe outcomes for those who become infected, including hospitalization and death – thus reducing the burden on the health care work force.

Exacerbating the general vaccine fatigue is decision fatigue, Hackell said.

People have to choose whether to get the flu vaccine each year – and more recently, they have to make decisions about Covid-19 vaccine updates. Each new decision opens the door for misinformation or disinformation to seep into the process.

“If it were a vaccine like measles, where it is really effective and it’s not repeated, it might be different,” Hackell said. “But we have to compare it to Covid and flu vaccines, where the efficacy is less than dramatic, and when there’s a lot of controversy going on, I think that spills over.”

Health care professionals are worn out too, experts say.

“I think there’s fatigue, moral injury, call it burnout on the part of providers as well. We’re not pushing it as hard,” said Hackell, who is also chair of the American Academy of Pediatrics Committee on Practice and Ambulatory Medicine. “It gets very difficult to keep having these unproductive conversations over and over again. And there’s so much more respiratory illness now that I don’t know that the time is there to have these long discussions when your office is packed with sick kids.”

Uptake for the updated Covid-19 booster has also been lackluster: Fewer than 1 in 7 eligible people have gotten one since it was authorized in the fall, according to CDC data.

Ongoing messaging from the White House urges Americans to get their updated Covid-19 booster shot and the flu shot at the same time.

But despite the convenience of getting both shots at once, there’s evidence that linking the two isn’t the best way to boost coverage rates for either.

There has always been hesitancy around vaccination, but it has become highly politicized during the Covid-19 pandemic.

“We still have plenty of people in this country who do not believe in the flu or the Covid vaccine that we haven’t been able to win over,” said Lori Tremmel Freeman, chief executive officer of the National Association of County and City Health Officials. “Flu is serious in our country, and it kills a lot of people, and it hospitalizes a lot of people, and it attacks the young and old. And so we should pay more attention to it.”

But even when interest in booster shots was highest, it was rare for people to get both shots simultaneously.

Self-reports to the CDC’s V-safe monitoring system show that fewer than 1 in 10 people who got a Covid-19 booster between September 2021 and May 2022 got a flu shot at the same time.

“We give multiple vaccines to our kids at the same time, but we haven’t typically done that for adults,” said Tan, former liaison to the CDC’s vaccine advisory committee for the American Medical Association.

Trying to persuade people to do something new can add to the hesitancy that’s already become so pervasive and make them less likely to come in at all. Instead, people seem to be much more likely to accept the offer of a flu vaccine at an appointment they scheduled to get a Covid-19 vaccine booster, or vice versa.

“Some confidence is given by direct interaction with a health-care provider – in this case, the pharmacist or the physician or the clinician – who is able to reassure the patient that it’s safe,” Tan said. “In that personal conversation between the provider and the patient, the patient ends up being converted and getting the vaccine. It’s a testimony also to our remarkable health-care providers.”

The message might finally be sticking. At Walgreens locations, co-administration of the flu and Covid-19 vaccine is 70% higher this year than it was last year, according to data shared with CNN.

Tan says there have been signs of improvement in recent weeks.

Pharmacies are becoming significantly more popular than doctors offices among adults as they choose where to get the flu shot, and CDC data shows that the number of flu vaccines given in pharmacies this season is actually outpacing last year. It’s a sign that there are more opportunities to reach a broader group of otherwise healthy adults who are less likely to have a primary care provider, Tan said.

“At least we’ve got the uptick now, as opposed to this continuous decline that we were seeing four weeks ago,” he said. “But while I’m sounding positive, I want to remind us all that we need to be better than we currently are.”

And while battling vaccine fatigue is a challenge, it’s not an excuse to let vaccination rates lapse.

“In many circumstances, we can overcome fatigue with access,” Tan said.

In public health, “we need to start looking outside the box to find out what messaging needs to change so that we can think out of the box and make people motivated to look for the flu vaccine again. Right now, it’s way too much of a vaccine of convenience.”

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4-day work week experiment deemed a success, with higher productivity and lower stress levels

Could a five-day work-week soon become a thing of the past?

The results of a six-month experiment with the participation of dozens of companies are now in: A four-day work week may actually be better for business.

Workers reported lower levels of stress and fatigue and company revenue was often higher compared to the prior year.

The experiment involved 33 companies and more than 900 employees.

In fact, out of the 33 companies, 27 completed a survey after the experiment and none of those said they were planning to go back to the five-day work week.

A separate six-month trial is currently underway in the United Kingdom, with 70 companies and more than 3,000 workers participating. Results are due in February.



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Woman Thought Swollen Armpit, Fatigue Were Pregnancy. She Had Lymphoma.

  • Erin Basinger thought she had a swollen armpit and was tired because she was a new mom. 
  • She thinks fatphobia delayed her stage 4 cancer diagnosis.
  • Fat pregnant patients receive negative messages from clinicians, including that they’re bad moms.

When Erin Basinger went wedding dress shopping in 2019, she struggled to find bras that would accomodate the growing mass under her armpit, and dresses that wouldn’t accentuate it. 

So she bought a wireless bra and a looser-fitting dress, and tried to push her concerns about the lump aside. After all, she’d always had some fatty tissue in that area and had recently undergone surgery for carpal tunnel syndrome. Perhaps, she thought, the procedure had prompted some fat redistribution or swelling.

Even when it continued to grow during and after her first pregnancy in 2020, Basinger chalked it up to hormones. She’d attended the standard prenatal and postpartum visits, and the doctor hadn’t raised any concerns.  

Basinger, now 36, had been battling extreme fatigue too — “scream-singing” to keep her eyes open in the car, and pulling over to nap when that failed. Still, she figured, that’s what pregnancy and new parenthood must be like. 

But more than six months postpartum, the mass had grown to the size of a grapefruit. After consulting with her sister, a nurse, Basinger visited a new doctor to specifically ask about the lump in December 2021. 

A few tests and referrals later, she was diagnosed with stage 4 non-Hodgkin’s lymphoma. She had an aggressive subtype that had spread to her head, neck, chest, abdomen, pelvis, and parts of her bones. 

“My PET scan lit up like a Christmas tree,” she said. “It was terrifying in general, and for me it was terrifying because I had a seven-month-old.” 

She shared her story — including how she thinks weight stigma played a role in her delayed diagnosis — with Insider to encourage women to advocate for themselves, and to validate pregnant patients who also feel they have been overlooked, if not downright ridiculed, for their weight. 

“I want other people to know: I’m fighting for you, even if you feel like you can’t fight for yourself,” she said. 

Basinger suspects doctors dismissed the lump as ‘just fat’ 

Basinger, a communications professor for the University of North Carolina Charlotte’s health psychology graduate program, wishes she had better advocated for herself when she first thought something was off. “That’s my biggest regret,” she said. 

But she also can’t help but think weight stigma contributed to her delayed diagnosis. “When I look back, I think maybe that was incompetence,” she said. “I suspect there was also probably some fatphobia there, like, ‘She’s fat, so this is probably just fat.'”

She has a lifetime of anecdotes to back that suspicion up. Doctors chalked up her rheumatoid arthritis to fatness, for example, and said her request to be tested for PCOS was just an “excuse” for her size. 

“Every time I went to the doctor, it was like, ‘Well it’s probably because of your weight,'” she said. “And it’s like, ‘I think if I hurt my elbow, it’s just because I hurt my elbow.'” 

That didn’t change before or during her pregnancy. When she got her IUD removed, the OB-GYN warned her that infertility and pregnancy loss were likely. “Her words were really just a dark cloud over my pregnancy because I was constantly afraid that I was going to miscarry,” Basinger said. 

Doctors also told her that if she gained more than 19 pounds while pregnant, she’d have to leave the state-of-the-art practice where she was being monitored to deliver at a poorly rated hospital because it had a NICU.

“It just felt like this consequence hanging over my head,” Basinger said. 

Weight stigma can contribute to worse outcomes in fat pregnant patients 

While there are links between bigger bodies and pregnancy complications, it’s unclear how much of that is physiological (fat affecting how hormones are stored) versus structural (ultrasounds not working well on larger bodies or clinicians not trained in delivering anesthesia to people with more fatty tissue). 

Confounding issues like an increased risk of gestational diabetes in higher-weight moms-to-be play a role too. 

Generally, health behaviors — how you eat, move, sleep, and manage stress, for example — are better indicators of health than size, pregnant or not, evidence suggests. 

But healthcare providers often emphasize a pregnant person’s weight above all else, leading to guilt and shame, which is health-diminishing itself, research shows. 

In her October 2022 study, conducted with UNC colleagues Margaret M Quinlan and Margaret Rawlings, she surveyed 237 fat people about the messages they received before, during, and after pregnancy. They found the most memorable messages came from healthcare providers, and the vast majority of those messages were negative. 

For instance, clinicians insinuated that fat moms are bad moms, and that it’s their fault medical equipment isn’t made for their bodies. 

Some pregnant people also reported being denied fertility treatments or care from midwives based on their size. “That is openly saying: ‘We don’t think you deserve to reproduce at your size,’ or, ‘You body is not capable of doing this naturally,'” Basinger said. 

Others said weight-loss during pregnancy was praised, despite its dangers, and that they were encouraged to breastfeed to lose weight — not because of its benefits to the baby. One participant said her doctor blamed her size for her pregnancy loss.

Erin Basinger with her son Joiner, who’s now 17 months.

Easterday Creative



These direct and indirect messages aren’t just hurtful, they can exacerbate mental and physical health issues in fat pregnant patients. One study found weight stigma in pregnancy was linked to worse healthcare treatment, mental health symptoms, poorer health behaviors, and negative pregnancy outcomes.

In one extreme example, a participant in Basinger’s survey said her stillbirth was related to weight stigma. When the external monitor stopped working during labor, she said clinicians assumed it was due to her size rather than malfunctioning equipment, and didn’t work to fix it. When a nurse finally helped, she said, “My baby was dead.” 

Basinger went through six rounds of chemotherapy while a mom to an infant 

After her cancer diagnosis, she went through six rounds of chemotherapy, which, she said, was “horrific.” 

She’s now in remission, and grateful for her hematologist who focused on treating her cancer — not discussing her weight.

“I do not often have incredible experiences with doctors, so I’m very thankful to have gotten competent care with him because he saved my life in a very literal way,” she said. 

She hopes sharing her and others’ experiences can inspire more doctors like him. In the meantime, she encourages fat moms-to-be to seek weight-inclusive clinicians and to combat stigma by educating themselves with books like “Fat and Fertile.” 

“It was so comforting to me to find those resources and know my body is powerful and beautiful and can bring a healthy baby into the world,” Basinger said. “And I did, contrary to what my doctors told me would happen. I had a beautiful baby boy who is just the light of my life.” 

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Long-COVID symptoms worsened by stressful events

A recent study published in the Journal of Neurological Sciences reported that life stressors impact post-acute symptoms and long-term outcomes after hospitalization for coronavirus disease 2019 (COVID-19).

Post-acute sequelae of COVID-19 (PASC) have been observed in 25% to 69% of non-hospitalized patients and 33% to 90% of hospitalized patients. The variable prevalence could stem from differences in study design, symptoms, and assessment timing. Notwithstanding the numerous studies reporting the prevalence of post-COVID-19 sequelae, there is limited data on predictors of long-term quality of life and cognitive and functional outcomes.

Study: Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization. Image Credit: / Shutterstock

About the study

In the present study, researchers prospectively examined the impact of demographics, hospital clinical variables, pre-COVID-19 comorbid conditions, and life stressors on six-month and one-year outcome metrics post-COVID-19 hospitalization. This observational study was conducted on patients hospitalized with COVID-19 from March 10 to May 20, 2022.

Follow-up interviews were conducted six months and one year after the initial COVID-19 diagnosis. Subjects were eligible if they were 18 years or older and hospitalized with a positive SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) test, with consent for the follow-up interview. Individuals were excluded if evaluated in the emergency room or outpatient setting.

Data on demographics, medical/neurologic history, new in-hospital neurologic or other complications, and medications used during acute COVID-19, were recorded. Disease severity was graded based on ventilation requirement and sequential organ failure assessment (SOFA) score. The modified Rankin scale (mRS) was used to assess subjects’ pre-COVID-19 baseline functional status. 

Longitudinal assessments were conducted via telephonic interviews. Contact was attempted at six and 12 months post-initial COVID-19 diagnosis. Functional and disability status was assessed using the mRS; cognitive outcomes were examined with the telephone Montreal Cognitive Assessment (t-MoCA).

The Barthel index was used for assessing activities of daily living (ADL), and the self-reported health metrics of depression, fatigue, sleep, and anxiety, were collected through the quality of life in neurologic disorders (NeuroQoL) short forms. PASC outcomes were defined as new/persistent symptoms occurring four weeks after COVID-19.

Findings

Follow-up interview attempts were made on 790 and 590 patients at six and 12 months, respectively. Of these, only 382 (48%) and 242 (41%) patients completed interviews at six and 12 months, respectively. Participants who completed only the six-month interview were older (median age: 69 years) than those completing the 12-month (65 years) interview.

No differences were found in sex, education level, race, pre-COVID-19 mRS scores, history of dementia/psychiatric disease, COVID-19 severity, and the rates of neurologic complications during hospitalization between patients who completed interviews at six months and 12 months. Headache, anxiety, cognitive abnormalities, depression, fatigue, and sleep disturbances were the common neurologic symptoms at 12 months.

About 90% of patients at six months and 87% at 12 months showed abnormalities on at least one assessed metric, with abnormalities on the mRS and t-MoCA being the most prevalent. A small but significant correlation was observed between post-acute COVID-19 symptoms and NeuroQoL anxiety scores ≥ 60. In addition, the authors noted an association of older age with poor mRS, t-MoCA scores, and Barthel Index at both time points and with NeuroQoL depression scores at one year.

The female sex was linked to elevated anxiety scores at one year and poor Barthel Index at six and 12 months. Neurologic complications such as hypoxic-ischemic brain injury and toxic metabolic encephalopathy strongly predicted poor Barthel Index and mRS at six and 12 months and worse fatigue and depression scores at one year. Poor SOFA scores and mechanical ventilation predicted a poor Barthel Index at six months.

The researchers did not find any consistent effect of COVID-19 medications on outcome metrics. However, more than 50% of participants reported having experienced a minimum of one life stressor in the month preceding the follow-up at 12 months. New personal illness, social isolation, financial insecurity, and illness/death of a close acquaintance were the most common life stressors.

The presence of stressors was strongly linked to post-acute COVID-19 symptoms and poor NeuroQoL scores. There was a significant association between food and financial insecurity, new disability/death of close contact, social isolation, and personal illness with worse NeuroQoL metrics. In contrast, new disability and personal illness were associated with Barthel Index and mRS.

Conclusions

In summary, the authors found independent associations of conventional predictors of poor outcomes, such as advanced age, poor pre-COVID-19 functional status, and disease severity, with worse t-MoCA, Barthel Index, and mRS scores and post-acute symptoms of COVID-19. In addition, they found that life stressors negatively impacted post-acute COVID-19 symptoms, depression, fatigue, sleep, and disability metrics. Taking life stressors into account, interventions aimed at alleviating life stress are associated with better cognitive, neuropsychiatric, and functional outcomes 12 months after hospitalization with COVID-19.

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