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How black hole thought experiments help explain the Universe

Albert Einstein’s theory of gravitation, known as general relativity, is intimidating, even for highly trained theoretical physicists. In his theory, matter and energy cause space-time to curve. In most situations, this warping is so small as to be unobservable, even with powerful and sophisticated instruments. In fact, for many years after Einstein put forth his theory in 1916, there were only three situations in which small corrections to Newton’s classic laws of gravity (the force we feel here on Earth) could be observed: the bending of light by the Sun during a solar eclipse; a small anomaly in the motion of Mercury; and a small shift in the wavelength of light due to gravitation. Since that time, the situation has dramatically changed. General relativity has provided us with a framework for thinking about the Universe as a whole, and plays a role in much of what astronomers understand about stars. It even plays a role in the GPS system that helps us navigate the roads.

Einstein’s equations ultimately revealed a set of previously unknown, ultradense cosmological objects: black holes. The mathematics of Einstein’s equations showed that light starting inside the black hole could get only so far. That distance, known as the Schwarzschild radius, can be thought of as the surface of the black hole; this surface is known as the horizon, beyond which light cannot escape. Near and within the horizon, space and time are modified so violently that it even becomes tricky to figure out what is space and what is time.

No one could see inside this kind of object, but speculations on their nature date to the work of J Robert Oppenheimer (famed for his leadership of the atomic bomb project during the Second World War) and John Wheeler, a Princeton theorist who provided, among other things, the name ‘black hole’.

Over the past half-century, astronomers have found black holes in great numbers around the Universe. Some are the result of stellar collapse, and have masses typically a few times larger than that of our Sun. Much more massive ones exist at the centres of most galaxies, including our own. Smaller black holes are typically ‘seen’ as they swallow matter from companion stars; the large black hole at the centre of our galaxy was discovered through its effects on the motion of stars orbiting about it. We may never be able to literally peer inside a black hole, but knowledge of the cosmos and emerging theories of physics allow us to think through their nature; the modus operandi for this kind of exploration, the thought experiment, has been a cornerstone of physics since Einstein dramatically altered our understanding of space and time.

Einstein’s theory that the Universe is curved and time is relative has been subject to direct experimental and observational study for more than a century – but thought experiments played a major role, as well. One of the most famous thought experiments of all time juxtaposed Einstein’s general relativity, which looked at systems as large as the cosmos, with quantum mechanics, also referred to as quantum theory, which resulted from experimental studies of objects on the scale of atoms or smaller.

Prior to the emergence of quantum mechanics, physicists thought of atoms as something like billiard balls. In the pre-quantum or classical view, their motion was governed by Isaac Newton’s laws, which allow a person, given knowledge of the basic forces of nature, to predict the motion of the particles in the future. But quantum mechanics called this viewpoint into question. Instead, it suggested an alternative picture of reality, coded in the Schrödinger equation – which provided the probability, though not the certainty, that an electron would be located at a given spot at a particular point in time. It was the physicist Max Born who made the radical proposal that quantum mechanics predicted probabilities of various outcomes, rather than a single certain result. Critical to his assertion was a set of thought experiments. Born asked what Schrödinger’s equation would predict for the outcome of the collision between two atoms, or an atom and an electron. Newton’s billiard ball outlook holds only when the probability of one particular outcome is far larger than that of any other.

Thought experiments suggested the widely separated elements would still be entangled

The notion deeply troubled Einstein, provoking his complaint in a letter to Born in December 1926: ‘Quantum mechanics is certainly imposing… The theory says a lot, but does not really bring us any closer to the secret of the “old one”. I, at any rate, am convinced that He does not throw dice.’

In 1927, Werner Heisenberg summarised the distinctions between the physics of Newton and that of the Schrödinger equation in his uncertainty principle, which sets limits on what one can measure about a system. The location of a particle, would always be a question of probability, never a sure thing. He arrived at this principle by considering various thought experiments, where he asked how particular measurements might actually be performed. Einstein tried to demolish the quantum theory through sharp critique, continually challenging Niels Bohr, a Danish founder of quantum mechanics and a leader in the effort to interpret the theory with thought experiments similar to those of Born and Heisenberg. At first glance, these seemed to show that quantum theory and its probability interpretation did not make sense. The questions Einstein asked were often tough, but Bohr, sometimes after a prolonged period of thought, invariably found a way to resolve each paradox. One such experiment, known as the EPR paradox (for Einstein and his two assistants, Boris Podolsky and Nathan Rosen), involved the connections between two widely separated parts of a single system. Thought experiments suggested the widely separated elements would still be entangled, with one part of the system invariably providing information about the other. This was eventually turned into a real experiment, proving quantum mechanics correct.

So what does all this have to do with black holes? A real-world experiment sets the stage.

According to the rules of classical physics, an object with electric charge, like an electron or proton, emits light as it speeds up or slows down. Einstein understood that, in a similar manner, his general relativity would lead to waves of the gravitational field – gravity waves – when mass or other forms of energy sped up or slowed down. These waves, in turn, would push and pull on matter as they passed by. Because the gravitational force is so much weaker than electricity and magnetism, these effects would be minuscule, even when huge amounts of mass are involved.

The first experimental programme with any real hope to detect these tiny gravitational waves began in the 1990s, and was known as LIGO, for Laser Interferometer Gravitational-Wave Observatory.

The programme was based on an outcome of general relativity understood early on by Einstein: when two planets collide, the mass involved would be insufficient to perceptibly impact the shape of space-time. But when two superdense objects like black holes collide, they would distort space-time enough that the effect could be detected. According to Einstein’s theory, these waves, travelling through space from their source, would stretch the space around them, ever so slightly. Objects nearby would appear slightly longer and then slightly shorter, and then slightly longer again. This stretching and shrinking would alert us that the objects had been there at all.

Now, when I say slightly, I mean slightly. The LIGO gravitational-wave detectors are long metal tubes each 4 kilometres long. Waves from colliding black holes stretch and shrink these huge bars by about 10-18 cm, an amount 105 times100,000 times – smaller than an atomic nucleus. Put another way, as a fraction of its length, each bar changes by about a trillionth of a trillionth of its length.

Throw in tables, chairs, planets, other stars, and the black hole’s mass increases and its horizon area increases

Only over the past decade has the detector picked up gravitational waves from collisions of neutron stars and black holes. With this discovery, a whole new way to study the Universe has emerged.

Yet these experiments go only so far. Indeed, in a universe governed by quantum mechanics, there are aspects of black holes that are far from clear. Because, in Einstein’s theory, a black hole can’t emit light or transmit information in other ways, they are almost featureless. If you know their mass, their electric charge, and how fast they spin, you know everything you can possibly know about them. They may have arisen from the collapse of a complicated star, surrounded by planets with advanced civilisations, but when they formed, all of that information simply vanished. This is different from a fire or an explosion, where you might hope, with a huge amount of work, to reconstruct all the original information by looking through the ashes and the outgoing light and heat. In the collapse of a black hole, such reconstruction seems impossible.

https://d2e1bqvws99ptg.cloudfront.net/user_image_upload/2165/BH_Accretion_Disk_Sim_360_1080.mp4
This new visualisation of a black hole illustrates how its gravity distorts our view, warping its surroundings as if seen in a carnival mirror. The visualisation simulates the appearance of a black hole where infalling matter has collected into a thin, hot structure called an accretion disk. The black hole’s extreme gravity skews light emitted by different regions of the disk, producing the misshapen appearance. Created by NASA Goddard Space Flight Center/Jeremy Schnittman

One physicist who tried to glean more through thought experiment was the late theorist Jacob Bekenstein of the Hebrew University of Jerusalem. He noted an analogy between black holes and the second law of thermodynamics. The second law says that entropy – which is a measure of disorder – always increases. For black holes, there is also a quantity that always increases: the area of the black hole surface, its horizon. Whenever you add something to a black hole – say throwing in tables, chairs, planets, other stars – the mass increases and the area of the horizon increases. Bekenstein proposed a precise relationship between the black hole area and entropy, and suggested that black holes were actually thermodynamic systems with a temperature.

In physics, we think of temperature as a measure of the energy within some set of particles – atoms, molecules, photons. Yet, from the outside, we have no information about the black hole apart from some gross properties such as its mass, and we certainly can’t identify things like particles.

It was Stephen Hawking who, in the early stages of his career, finally discovered the sense in which black holes have a temperature. Hawking had an interest in extreme situations in general relativity, such as the earliest instants after the Big Bang and the interior of black holes. Now thinking about the behaviour of particles such as electrons and photons near the horizon of a black hole – thought experiments again – he realised that black holes are not really black; they radiate particles now known as the ‘Hawking radiation’. This is an intrinsically quantum phenomenon. The uncertainty principle permits brief violations of energy conservation in ordinary space-time. As a result, for an extremely short time, a particle and its antiparticle (in the case of an electron, for example, the antiparticle has the same mass but the opposite electric charge, known as the positron) can appear, even in a complete vacuum, and then annihilate each other and disappear again. For us, there is no observable consequence because energy is conserved.

But Hawking realised that some of these flickering particles could borrow some of the enormous energy of the black hole and become real. If produced near the horizon, one of these virtual particles could fall back into the black hole while the other escapes. Hawking found that the particles were emitted just as they would be from an object with the temperature predicted by Bekenstein. (The radiation from an object with a given temperature is called ‘blackbody radiation’ and has characteristic features; the most dramatic example is the Universe itself, whose temperature is 2.7 degrees Kelvin).

In short, the black hole appears to be a much more complicated object in a quantum world than in a classical one. In the quantum world, there’s a lot going on inside. The black hole in the quantum universe is not static. As it emits particles, it gradually evaporates, eventually disappearing altogether.

For a black hole formed in the collapse of a star a bit more massive than our Sun, the time for the entire object to evaporate is very long – about 1067 years, far, far longer than the present age of the Universe. But we can contemplate smaller black holes, which might be disappearing today. At the end of their lifetimes, there would be a large burst of energy. Astrophysicists are currently searching for this possibility. But we’d have to be quite lucky to find such a thing and, so far, there is no evidence for black holes of this size.

Hawking’s theoretical discovery of the Hawking radiation, possible through thought experiment, was a major accomplishment. It brought general relativity and quantum theory together in a remarkable way. But performing still another thought experiment, Hawking was puzzled by features of this radiation – or more precisely, its lack of features. Critical to Born’s probability interpretation of quantum mechanics was that something always happens. If you add up the probabilities for anything that may happen, you will find that the total probability is one. This can be formulated as a statement about information: if one knows everything one can know about a system at one time, one can know everything about it at later times. But this did not seem to be the case for radiation from black holes.

These ideas may be unfamiliar – indeed they are unclear to many physicists, so it is worth elaborating a bit. The fact that the probability of all outcomes is one is illustrated by a familiar pastime. If you enter your state or national lottery, you focus on your chances of winning. If you buy one ticket and there are 10 million lottery tickets sold, your chances of winning the jackpot are 1 in 10 million. That’s a really minute chance. But I either win or lose the lottery: the chance of winning or losing is 100 per cent.

What does it mean for information to disappear? Of course, we all forget things, lose records of various types, or deliberately shred or burn papers. But we believe that with enough patience and resources, we could reconstruct this information. The amount of information in a system (or the Universe) doesn’t change, though much of it may be hard to access. For a complicated system, like a collapsing star, there is a lot of information – an unimaginably large amount. In classical physics, there would be the positions and velocities of all the nuclei and electrons. In quantum mechanics, there are complicated relations between all of them; one can’t give the probability that one particle is at a point without specifying also the probability of finding all the other particles at particular places as well.

There is a situation where black holes could exist and quantum mechanics could make sense: string theory

So a collapsing star contains a huge amount of information. Thanks to Hawking, we know that, if the star is heavy enough, it forms a black hole and then slowly evaporates, emitting radiation. The vast amount of information that was contained in the initial star has been reduced to just the temperature of a warm body. Hawking, in his 1976 paper, argued that the information was simply lost. Quantum mechanics, he asserted, breaks down near black holes.

Many leading theorists have struggled to resolve the puzzles raised by this thought experiment. Some have argued that, indeed, one has to redo quantum mechanics or general relativity to resolve Hawking’s paradox. Others have been more sceptical of Hawking. Perhaps, for example, the evaporation of a black hole is like a lump of ash from the burning of a log in a fireplace. Surely the laws of quantum mechanics don’t break down when an object burns? In that case, the resolution of the puzzle is that the outgoing radiation is not exactly that of a black body because subtle connections between the outgoing photons remain intact. But it was soon realised that the answer to Hawking’s question about the black hole problem could not be so simple; the structure of space and time makes it hard to understand how such correlations might arise. There were other proposals, none very satisfying. Perhaps Hawking was right: just as Newtonian physics was usurped by quantum mechanics and general relativity on large or tiny scales, something had to give here as well.

It turns out that there is a situation where black holes could exist and quantum mechanics could make sense: string theory. String theory, also emerging from thought experiments, replaces the particles of quantum mechanics with one-dimensional strings. That concept has provided at least a partial resolution of the puzzle. Two theorists at Harvard University – Cumrun Vafa and Andrew Strominger – building on the work of the late Joseph Polchinski, of the University of California at Santa Barbara, were able to understand the temperature of certain idealised black holes in quantum mechanical terms. In other words, the information, at least for these idealised systems, somehow survives, evading Hawking’s paradox.

But while this result settled the question in an abstract way, it left many physicists dissatisfied. Because the calculation is done in a situation that doesn’t much resemble an astrophysical black hole, it is hard to figure out just what went wrong with Hawking’s argument.

There remains something important about the way general relativity works that we don’t yet fully understand. It may be that the rest of the story will be rather mundane, but it seems likely that fully resolving these questions will yield dramatic new insights into the quantum nature of space-time, and might answer some big questions we have about the Universe as we observe it. One of the biggest puzzles in our current understanding of nature is that most of the energy of the Universe – about 70 per cent – exists in a strange form with negative pressure, known as the dark energy. But it is very hard to understand why there is so little of it.

It is conceivable that a thought experiment resolving Hawking’s puzzle might provide some clues. The most radical possibility is that space-time is not the basic arena for the phenomena of nature. A being living in a crystal, for instance, would experience something like space-time, but would have a very different character. Condensed matter physicists would say that space-time is emergent. The basic underlying entity might be something else entirely. Perhaps one day our science and technology will be so advanced that actual experiments will reveal what it is – but, until then, thought experiments involving black holes, among other phenomena, will have to light the way.

Adapted excerpt from the book This Way to the Universe by Michael Dine, published by Dutton, an imprint of Penguin Publishing Group, a division of Penguin Random House LLC. Copyright © 2022 by Michael Dine

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Watch ovarian cells and other wild experiments launch to ISS Sunday

Update for 5 am ET, Nov. 7: Northrop Grumman is now counting down to launch the Antares rocket and Cygnus NG-18 cargo ship from NASA’s Wallops Flight Facility today at 5:32 a.m. EST (1032 GMT).


Ovarian cells from cows are moo-ving to the space station, along with a set of other intriguing science experiments.

The latest International Space Station (ISS) shipment, coming courtesy of a Northrop Grumman robotic Cygnus cargo spacecraft, will blast off on the company’s Antares rocket no earlier than 5:50 a.m. EST (1050 GMT) on Sunday (Nov. 6) from the Mid-Atlantic Regional Spaceport at Wallops Island, Virginia. You can watch live here at Space.com, courtesy of NASA Television. Coverage starts 20 minutes before launch.

After arriving at the ISS on Tuesday (Nov. 8) and getting installed, the bovine cell bonanza (OVOSPACE (opens in new tab)) will look at how microgravity affects the growth of cells. This could eventually have applications for human fertility treatments, experiment co-principal investigator Andrew Fuso told Space.com.

“This is really our first approach, and it is for the moment an observational study,” Fuso, who is also an associate professor at the Sapienza University of Rome, said during a livestreamed press conference on Oct. 25. After the results are in, the investigators will research possible drug interventions or edible (nutraceutical) additives to improve fertility outcomes in future studies, he added.

Related: NASA-funded spacesuit tech may help with menopause relief

Also heading to the orbiting laboratory is a 3D printer known as the BioFabrication Facility (opens in new tab), which also reached space in 2019 to print some human knee cartilage (specifically, the meniscus), and a set of human heart cells.

“We brought [the printer] back to our lab in Indiana … to add a few new capabilities, such as the ability to finally control the temperature of each printhead, and now we’re excited to see it launch,” said Rich Boling, vice president of corporate advancement for in-space manufacturing and operations at the company Redwire Space, in the same conference.

Related: Bioprinter will 3D-print human tissue on the space station

After another space shipment, Redwire will print a new meniscus and study it in the lab to get ready for possible patient transplants in the future, Boling said. Blood vessels and cardiac tissues will be manufactured as well. Redwire also plans drug efficacy testing in space on “organoids,” or miniature versions of organs.

Boling hinted that such research would continue on Orbital Reef, a Redwire-supported commercial space station in development for flight in the 2030s. The project is led by Blue Origin and Sierra Space, and includes partners like Boeing and Amazon.

Some of the other experiments making their space debut include, in the words of NASA (opens in new tab):

  • Assessing how plants adapt to space: Plants exposed to spaceflight undergo changes that involve the addition of extra information to their DNA, which regulates how genes turn on or off but does not change the sequence of the DNA itself. This process is known as epigenetic change. Plant Habitat-03 (opens in new tab) assesses whether such adaptations in one generation of plants grown in space can transfer to the next generation.
  • Mudflow mixtures: Climate change and global warming are contributing to increasing occurrence of wildfires. When a wildfire burns plants, combusted chemicals create a thin layer of soil that repels rainwater. Rain then erodes the soil and can turn into catastrophic mudflows that carry heavy boulders and debris downhill, causing significant damage to infrastructure, watersheds, and human life. Post-Wildfire Mudflow Micro-Structure (opens in new tab) evaluates the composition of these mudflows, which include sand, water, and trapped air.
  • First satellites from Uganda and Zimbabwe: BIRDS-5 (opens in new tab) is a constellation of CubeSats: PEARLAFRICASAT-1, the first satellite developed by Uganda; ZIMSAT-1, Zimbabwe’s first satellite; and TAKA from Japan. BIRDS-5 performs multispectral observations of Earth using a commercial off-the-shelf camera and demonstrates a high-energy electronic measuring instrument. The data collected could help distinguish bare ground from forest and farmland and possibly indicate the quality of agricultural growth. 
  • Powering the space station: Hardware to be installed outside the station in preparation for the installation of Roll-Out Solar Arrays (opens in new tab).

Elizabeth Howell is the co-author of “Why Am I Taller (opens in new tab)?” (ECW Press, 2022; with Canadian astronaut Dave Williams), a book about space medicine. Follow her on Twitter @howellspace (opens in new tab)Follow us on Twitter @Spacedotcom (opens in new tab) or Facebook (opens in new tab).



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Wild Experiments Are Trying to Bounce Radio Signals Off the Moon and Jupiter

The facility’s antenna array includes 180 antennas spread across 33 acres.
Photo: HAARP

An antenna field in Alaska that’s spawned no shortage of conspiracy theories has been carrying out a series of experiments that include sending radio signals to the Moon and Jupiter and waiting for pings back.

The High Frequency Active Auroral Research Program (HAARP) kicked off a 10-day science campaign that ran through October 28. On the agenda were 13 experiments that are pushing the limits of what the facility can do. “The October research campaign is our largest and most diverse to date, with researchers and citizen scientists collaborating from across the globe,” Jessica Matthews, HAARP’s program manager, said in a release.

HAARP is made up of 180 high-frequency antennas, each standing at 72 feet tall, stretched across 33 acres near Gakona, Alaska. The research facility transmits radio beams toward Earth’s ionosphere, the ionized part of the atmosphere that’s located about 50 to 400 miles (80 to 600 kilometers) above Earth’s surface. The ionosphere is filled with electrically charged particles, a result of being blasted by solar energy. HAARP sends radio signals to the ionosphere and waits to see how they return, in an effort to measure the disturbances caused by the Sun, among other things.

In one recent experiment, known as the “Moon Bounce,” a group of researchers from NASA’s Jet Propulsion Laboratory, Owens Valley Radio Observatory, and the University of New Mexico transmitted a signal from the HAARP antennas in Alaska to the Moon and then waited to receive a reflected signal back at the observatory sites in California and New Mexico.

The purpose of the experiment is to study how the three facilities in Alaska, California, and New Mexico can work together for the future observations of near-Earth asteroids. The facility may be able to transmit a signal to an asteroid flying by Earth and receive a signal back that will hint at the space rock’s composition.

Another experiment sent a radio beam to Jupiter, currently located about 374 million miles (600 million kilometers) from Earth. The hope is that the beam would reflect off Jupiter’s ionosphere and then be received at the New Mexico site.

The Jupiter experiment is run by the John Hopkins Applied Physics Labarotory and aims to provide a new way of observing the ionospheres of other planets. Considering how far Jupiter is from Earth, this experiment is a true test of HAARP’s signal-transmitting capabilities.

Another experiment is more on the artsy side. “Ghosts in the Air Glow” beamed video, images, spoken word, and sound art to the ionosphere and waited for the signal to bounce back to test the transitional boundary of the atmosphere.

HAARP was originally a project of the U.S. Air Force to study solar flares, which can disrupt Earth’s communications and electric grid. But in 2015, the Air Force decided it was no longer interested in maintaining HAARP, and ownership transferred to the University of Alaska. While it was under the purview of the Air Force, HAARP inspired some wild conspiracy theories, including that its antennas were being used to alter the weather, create deadly hurricanes, and even control minds.

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US military conducts test launch of hypersonic experiments for weapons development



CNN
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The US military conducted a successful test launch of a rocket with experiments for hypersonic weapons development at the Wallops Flight Test Facility in Virginia Wednesday.

The rocket carried 11 different experiments designed to test and collect data for hypersonic weapons research to support the joint Army-Navy program, the Navy said.

This was the second test carried out under the program focused on developing both sea and land-based hypersonic capabilities. The first test was conducted in October 2021.

In this test, a sounding rocket was fired from the launchpad, carrying out different experiments to gather data and collect information on components of hypersonic missiles, including heat-resistant materials and high-end electronics.

“The launch today went extremely well,” said Vice Admiral Johnny Wolfe, the director of Strategic Systems Programs who oversaw the test. “As a matter of fact, we’ve just gotten done looking through our key observables, and every piece of data that we wanted to collect – at least preliminarily – has shown that we collected all that data.”

A second rocket is scheduled for launch on Thursday and will carry out an additional 13 experiments designed to inform hypersonic weapons development, the Navy said.

The data collected from these tests will help in the development of the Navy’s Conventional Prompt Strike hypersonic system and the Army’s Long Range Hypersonic Weapon. The two programs will both use the Common Hypersonic Glide Body, a projectile carried atop a booster rocket that coasts towards its target at speeds greater than Mach 5.

Hypersonic weapons travel at speeds greater than Mach 5, or approximately 4,000 miles per hour, making them difficult to detect and intercept in time. The missiles can also maneuver and vary altitude, allowing them to evade missile defense systems.

The Pentagon has made the development of hypersonic weapons one of its top priorities after China conducted successful hypersonic launches last year and Russia has begun to use hypersonic missiles in its war in Ukraine.

After China tested a hypersonic weapon in 2021, Chairman of the Joint Chiefs of Staff Gen. Mark Milley called the test “a very significant technological event” that is just one element of China’s military capabilities.

“The Chinese military capabilities are much greater than that” single test, Milley said in October 2021. “They’re expanding rapidly in space, in cyber and then in the traditional domains of land, sea and air.”

Russia and China are ahead of US in hypersonic missile technology. Here’s why

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NIH probes whether Boston University COVID experiments should have triggered review

Boston University refutes report that lab created dangerous COVID strain


Boston University refutes report that lab created dangerous COVID strain

03:02

The National Institutes of Health is now examining whether experiments performed at Boston University should have triggered a federal review, the agency says, after scientists at the school tested strains they created of the COVID-19 virus combining the ancestral and Omicron variants.

Federal health authorities say they are looking into whether the scientists should have sought their permission before undertaking research that could lead to a “gain of function” in the virus gaining new or enhanced abilities, which can be “inherently risky.”

And locally, a spokesperson for the Boston Public Health Commission says it is now reviewing application materials from the study’s scientists “to confirm that the research was conducted in conformity with protocols, and that they were properly overseen.” 

The commission approved a proposed research protocol submitted by the scientists in March 2020, the spokesperson said.

However, Boston University says its research followed “all required regulatory obligations and protocols” to safely experiment with the viruses.

“Before anything is done in the [National Emerging Infectious Diseases Laboratories], it goes through multiple layers of careful safety review and this is done through committees that are part of Boston University and also committees that are outside of, independent of, BU,” Robert Davey, a professor at Boston University’s National Emerging Infectious Diseases Laboratories, said in a statement.

The scientists were studying what role the Omicron variant’s highly-mutated spike protein might play in its generally milder severity compared to previous waves. 

Mice were exposed to “chimeric recombinant” versions created by the scientists, which carried the Omicron variant’s spike protein combined with the “backbone” of the original strain. Similar kinds of recombinant variants have evolved in the wild.

Their findings were released Friday as a preprint that has yet to be peer-reviewed. The NIH’s scrutiny was first reported by Stat News.

Though NIH money was not directly sought for the experiments, the agency is probing whether it may have still been subject to their grants policy. 

The experiments may have also required clearance first by the federal government’s rules governing experiments that could lead to a “gain of function” in the virus, the NIH said. This kind of research is supposed to be vetted by a group of experts convened by the federal government before it can be funded.

However, Boston University says it “did not have an obligation to disclose this research” to the NIH.

While funding from the NIH’s National Institute of Allergy and Infectious Diseases was acknowledged by the scientists in their paper, Boston University said the grants were only for “tools and platforms” used by the scientists .

“NIAID funding was acknowledged because it was used to help develop the tools and platforms that were used in this research; they did not fund this research directly. NIH funding was also acknowledged for a shared instrumentation grant that helped support the pathology studies,” Rachel Lapal Cavallario, a spokesperson for the university, said in a statement.

News of the NIH’s probe follows coverage of the Boston University research first in the Daily Mail. The university had denounced the tabloid for sensationalizing their research, with “false and inaccurate” reporting that took their findings out of context.

For example, those early reports on the findings highlighted that 80% of infected mice died after scientists infected the animals with the recombinant strain, while none died after being exposed to the Omicron variant.

The university points out that the original variant led to 100% of the mice dying, meaning that their recombinant virus was made effectively “less dangerous.”

If there were any signs the viruses they created for their experiments were “gaining function,” the scientists would have “immediately” stopped and reported their research, Lapal Cavallario said.

The research was also conducted in the university’s “BSL-3” lab. That is the second-highest tier of precautions scientists can take when studying viruses, short of those taken for studying the most dangerous pathogens “for which no vaccine or therapy is available.”

“We take our safety and security of how we handle pathogens seriously, and the virus does not leave the laboratory in which it’s being studied,” Ronald Corley, director of Boston University’s NEIDL, said in a statement.

The study’s lead author, Mohsan Saeed, and other experts have cited other research that have performed similar kinds of experiments without controversy. 

One study co-authored by Food and Drug Administration researchers over the summer also generated “chimeric viruses” with the Omicron and ancestral strains to test on mice.

“In this case, we are interested in understanding viral genes or factors or mutations that attenuate SARS-CoV-2 so that we can use the knowledge to design live attenuated viral vaccines,” FDA spokesperson Abby Capobianco said in a statement.

The FDA’s internal research review committees approved the work, Capobianco said. The work was deemed not to be so-called “P3CO” research, which would have triggered a review before experiments that may “create, transfer, or use” enhanced potential pandemic pathogens (ePPP).

The Boston University preprint comes amid scrutiny of the federal government’s policies governing ePPP research, which are in the midst of a review by an NIH working group.

“It is concerning that this research – like the research in Wuhan that may have caused the pandemic – was not identified by the funding agency as possible ePPP research,” Rutgers University Professor Richard Ebright wrote on Twitter.

Ebright and others also disputed the university’s claim that the research was not a “gain of function” experiment.

“First, these are unquestionably gain-of-function experiments. As many have noted, this is a very broad term encompassing many harmless and some potentially dangerous experiments,” Marc Lipsitch, an epidemiologist at Harvard University and key official in the Centers for Disease Control and Prevention’s forecasting arm, said Wednesday on Twitter.



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Combining Heavy-Ion Experiments and Nuclear Theory

Artist’s rendering showing the simulation of two merging neutron stars (left) and the emerging particle tracks that can be seen in a heavy-ion collision (right) that creates matter under similar conditions in the laboratory. Credit: Tim Dietrich, Arnaud Le Fevre, Kees Huyser; background: ESA/Hubble, Sloan Digital Sky Survey

Combining heavy-ion experiments, astrophysical observations, and nuclear theory.

When a massive star explodes in a supernova, if it isn’t completely destroyed, it will leave behind either a black hole or a

Neutron stars are formed when a giant star runs out of fuel and collapses. They are among the densest objects in the cosmos, with a single cube sized piece weighing 1 billion tons (1 trillion kg.)

Throughout the Universe, neutron stars are born in supernova explosions that mark the end of the life of massive stars. Sometimes neutron stars are bound in binary systems and will eventually collide with each other. These high-energy, astrophysical phenomena feature such extreme conditions that they produce most of the heavy elements, such as silver and gold. Consequently, neutron stars and their collisions are unique laboratories to study the properties of matter at densities far beyond the densities inside atomic nuclei. Heavy-ion collision experiments conducted with particle accelerators are a complementary way to produce and probe matter at high densities and under extreme conditions.

New insights into the fundamental interactions at play in nuclear matter

“Combining knowledge from nuclear theory, nuclear experiment, and astrophysical observations is essential to shedding light on the properties of neutron-rich matter over the entire density range probed in neutron stars,” said Sabrina Huth, Institute for Nuclear Physics at Technical University Darmstadt, who is one of the lead authors of the publication. Peter T. H. Pang, another lead author from the Institute for Gravitational and Subatomic Physics (GRASP), Utrecht University, added, “We find that constraints from collisions of gold ions with particle accelerators show a remarkable consistency with astrophysical observations even though they are obtained with completely different methods.”

Artist’s depiction of a neutron star. Credit: ESO / L. Calçada

Recent progress in multi-messenger astronomy allowed the international research team, involving researchers from Germany, the Netherlands, the US, and Sweden to gain new insights to the fundamental interactions at play in nuclear matter. In an interdisciplinary effort, the researchers included information obtained in heavy-ion collisions into a framework combining astronomical observations of electromagnetic signals, measurements of

Reference: “Constraining neutron-star matter with microscopic and macroscopic collisions” by Sabrina Huth, Peter T. H. Pang, Ingo Tews, Tim Dietrich, Arnaud Le Fèvre, Achim Schwenk, Wolfgang Trautmann, Kshitij Agarwal, Mattia Bulla, Michael W. Coughlin and Chris Van Den Broeck, 8 June 2022, Nature.
DOI: 10.1038/s41586-022-04750-w



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Gravitational wave mirror experiments can evolve into quantum entities

Schematic of a laser interferometer used to observe gravitational waves. If the quantum uncertainty of the radiation pressure of the light is the dominant dynamic force acting on the mirrors, a common quantum object arises from the mirror and the reflected light beam. In this case, the sensitivity of the interferometer is optimal when measuring changes in mirror positions due to gravitational waves. Credit: Alexander Franzen

Quantum physical experiments exploring the motion of macroscopic or heavy bodies under gravitational forces require protection from any environmental noise and highly efficient sensing.

An ideal system is a highly reflecting mirror whose motion is sensed by monochromatic light, which is photoelectrically detected with high quantum efficiency. A quantum optomechanical experiment is achieved if the quantum uncertainties of light and mirror motion influence each other, ultimately leading to the observation of entanglement between optical and motional degrees of freedom.

In AVS Quantum Science, researchers from Hamburg University in Germany review research on gravitational wave detectors as a historical example of quantum technologies and examine the fundamental research on the connection between quantum physics and gravity. Gravitational wave astronomy requires unprecedented sensitivities for measuring the tiny space-time oscillations at audio-band frequencies and below.

The team examined recent gravitational wave experiments, showing it is possible to shield large objects, such as a 40-kilogram quartz glass mirror reflecting 200 kilowatts of laser light, from strong influences from the thermal and seismic environment to allow them to evolve as one quantum object.

“The mirror perceives only the light, and the light only the mirror. The environment is basically not there for the two of them,” said author Roman Schnabel. “Their joint evolution is described by the Schrödinger equation.”

This decoupling from the environment, which is central to all quantum technologies, including the quantum computer, enables measurement sensitivities that would otherwise be impossible.

The researchers review intersects with Nobel laureate Roger Penrose’s work on exploring the quantum behavior of massive objects. Penrose sought to better understand the connection between quantum physics and gravity, which remains an open question.

Penrose thought of an experiment in which light would be coupled to a mechanical device via radiation pressure. In their review, the researchers show while these very fundamental questions in physics remain unresolved, the highly shielded coupling of massive devices that reflect laser light is beginning to improve sensor technology.

Going forward, researchers will likely explore further decoupling gravitational wave detectors from influences of the environment.

More broadly speaking, the decoupling of quantum devices from any thermal energy exchange with the environment is key. It is required for quantum measurement devices as well as quantum computers.


Physicists develop a method to improve gravitational wave detector sensitivity


More information:
Macroscopic quantum mechanics in gravitational-wave observatories and beyond, AVS Quantum Science, 2022. aip.scitation.org/doi/full/10.1116/5.0077548
Provided by
American Institute of Physics

Citation:
Gravitational wave mirror experiments can evolve into quantum entities (2022, March 15)
retrieved 16 March 2022
from https://phys.org/news/2022-03-gravitational-mirror-evolve-quantum-entities.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



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High-Resolution Lab Experiments Show How Cells “Eat” – Solves 40-Year-Old Problem in Cell Biology

A new study shows how cell membranes curve to create the “mouths” that allow the cells to consume things that surround them.

“Just like our eating habits basically shape anything in our body, the way cells ‘eat’ matters for the health of the cells,” said Comert Kural, associate professor of physics at The Ohio State University and lead author of the study. “And scientists did not, until now, understand the mechanics of how that happened.”

The study, published recently in the journal Developmental Cell, found that the intercellular machinery of a cell assembles into a highly curved basket-like structure that eventually grows into a closed cage. Scientists had previously believed that structure began as a flat lattice.

Membrane curvature is important, Kural said: It controls the formation of the pockets that carry substances into and out of a cell.

The pockets capture substances around the cell, forming around the extracellular substances, before turning into vesicles – small sacs one-one millionth the size of a red blood cell. Vesicles carry important things for a cell’s health – proteins, for example – into the cell. But they can also be hijacked by pathogens that can infect cells.

But the question of how those pockets formed from membranes that were previously believed to be flat had stymied researchers for nearly 40 years.

“It was a controversy in cellular studies,” Kural said. “And we were able to use super-resolution fluorescence imaging to actually watch these pockets form within live cells, and so we could answer that question of how they are created.

“Simply put, in contrast to the previous studies, we made high-resolution movies of cells instead of taking snapshots,” Kural said. “Our experiments revealed that protein scaffolds start deforming the underlying membrane as soon as they are recruited to the sites of vesicle formation.”

That contrasts with previous hypotheses that the protein scaffolds of a cell had to go through an energy-intensive reorganization in order for the membrane to curve, Kural said.

The way cells consume and expel vesicles plays a key role for living organisms. The process helps clear bad cholesterol from blood; it also transmits neural signals. The process is known to break down in several diseases, including cancer and (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "https://connect.facebook.net/en_US/sdk.js#xfbml=1&version=v2.6"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk'));

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NASA reveals this year’s best scientific experiments on the ISS

NASA has shared photos of the best scientific experiments aboard the International Space Station (ISS) in 2021. 

In an online gallery, the US space agency included images from ‘breakthrough investigations’ ISS crew members worked on this year. 

These included growing vegetables in space, engineering cells for research into muscle growth and the use of virtual reality (VR) to learn how humans perceive time in low gravity. 

Chillies, lettuce and even the Chinese cabbage pak choi were harvested on the ISS as a part of plant research preparing astronauts for deep space missions.

Technologies were also tested for the upcoming Artemis missions to the Moon, set to take place in 2025, according to NASA. 

Crew-1 poses with the chillies they harvested on the ISS before eating them. This plant experiment was the longest in the history of the space station at 137 days. Studies like this one could help enable viable and sustainable crop production for future missions as humans explore the Moon and Mars

Crew-2 and Crew-3 – two missions to the ISS operated by NASA on SpaceX rockets – harvested crops of chilli peppers. NASA astronaut Kayla Barron can be seen here with a chilli crop

NASA astronaut Michael Hopkins enjoys the aroma of dwarf pak choi growing aboard the space station. The plants were grown for a study that explores space agriculture to sustain astronauts on future missions to the Moon or Mars

A closeup view of red liquid moving through the Plant Water Management 3 and 4 investigation aboard the station. The investigation demonstrates passive measures for controlling fluid delivery and uptake in plant growth systems. Reduced gravity creates challenges in providing adequate fluid and nutrition for plant growth. This investigation examines using other physical properties to replace the role of gravity

THE ISS: QUICK FACTS 

The International Space Station (ISS) is a large spacecraft in orbit around Earth. It serves as a home where crews of astronauts and cosmonauts live. 

The ISS is a unique science laboratory. NASA is using the space station to learn more about living and working in space. These lessons will make it possible to send humans farther into space than ever before

Several nations worked together to build and use the ISS. It orbits Earth at an average altitude of approximately 250 miles and travels at 17,500 mph. 

Source: NASA 

The ISS, operated by the space agencies of the US, Canada, Russia, Japan and Europe, orbits 250 miles (400 km) above the Earth. 

In 24 hours, the space station makes 16 orbits of our planet, travelling through 16 sunrises and sunsets. 

The space station has been continuously inhabited by humans for 21 years, supporting many scientific breakthroughs.  

In one photo from NASA’s gallery, European Space Agency (ESA) astronaut Thomas Pesquet – who completed his second stint at the ISS this year – can be seen working on a study called the ‘cardinal muscle investigation’. 

This study tests whether such engineered tissues cultured in space could provide a model for studying muscle loss in low gravity, which could help inform the Artemis missions. 

In space, the lack of gravity means muscles barely have to work and astronauts have a vigorous exercise routine to stop them from losing large amounts of muscle mass.

Another similar study uses a 3D kidney cell model known as a tissue chip to study the effects of microgravity on formation of microcrystals in kidney tubules. 

‘Results could support design of better treatments for conditions such as kidney stones and bone loss for astronauts and osteoporosis for people on Earth,’ NASA says. 

ISS astronauts are also making use of their unique vantage point above the Earth for storm and environmental monitoring.   

Crew members photograph Earth using digital handheld cameras to record how the planet is changing over time, from human-caused changes like urban growth to natural events such as hurricanes, floods and volcanic eruptions.

An international crew of seven people live and work while travelling at a speed of five miles per second, orbiting Earth about every 90 minutes. Here, the ISS is pictured from the SpaceX Crew Dragon Endeavour during a fly-around of the orbiting lab that took place as Crew-2 left station on November 8, 2021

ESA (European Space Agency) astronaut Thomas Pesquet works on the Cardinal Muscle investigation. This study tests whether such engineered tissues cultured in space could provide a model for studying muscle loss and assessing possible therapeutics

NASA astronaut Megan McArthur works on an experiment involving a 3D kidney cell model known as a tissue chip to study the effects of microgravity on formation of microcrystals in kidney tubules

One photo shows Hurricane Larry – which passed over Newfoundland in September – as seen from the station’s domed ‘Cupola’ window. 

Swells from Hurricane Larry caused rough surf and rip current conditions that caused five direct fatalities, an NOAA report published this month said. 

In August, NASA also shared images of Hurricane Ida taken from the ISS, showing the powerful Category 4 hurricane poised menacingly over North America. 

NASA astronauts are also using virtual reality (VR) and augmented reality (AR) aboard the ISS for some experiments. Unlike virtual reality (VR), AR layers computer-generated images on top of real-life scenes. 

They’re using Microsoft’s HoloLens headset to learn more about how humans perceive time in low gravity, as the lower speed of the body’s movement in space may affect time perception. 

In this image, Hurricane Larry is pictured out of station’s Cupola window with the solar arrays to the right, which convert solar energy to electrical power

Hurricane Ida is seen in this image taken aboard the International Space Station (ISS). The dangerous hurricane made landfall in Louisiana on August 29, 2021

NASA astronaut Shane Kimbrough carries the second ISS roll out solar array (iROSA) toward the space station’s Port-6 truss structure where he and fellow spacewalker Pesquet would go on to install it

‘Crew members wear a head-mounted VR display, listen to instructions, and use a finger trackball connected to a laptop to respond, NASA says. 

‘They take tests once a month during flight, as well as before launching to space and after returning to Earth, to evaluate adaptive changes.’ 

HoloLens is also being put to use as part of the Cold Atom Lab (CAL), a ISS quantum science facility that hosts experiments exploring properties of atoms. 

In July, the CAL team successfully demonstrated using an AR headset to assist astronauts with upgrade activities. 

NASA also captured an image of a hot flame of nitrogen-diluted propane created aboard the space station. 

It was formed as a part of the Cool Flames Investigation with Gases study, which aims to better understand flames that burn at extremely low temperatures. 

Without buoyancy, soot remains in the flame longer and forms large clusters.

This image shows a hot flame of nitrogen-diluted propane created aboard the space station inside the Combustion Integrated Rack

Astronaut Akihiko Hoshide of the Japan Aerospace Exploration Agency is pictured wearing a virtual reality headset and clicking a trackball for Time Perception, a study exploring how astronauts perceive space and time and possible effects on navigation and fine motor coordination in microgravity

NASA astronaut Megan McArthur wears the HoloLens headset to test an augmented reality (AR) application. AR adds sound, visual elements or other sensory stimuli to a real-life environment 

The ISS, which launched back in 1998, has had a busy year – multiple Soyuz spacecrafts carried astronauts to and from station, while the Crew 2, and Crew 3 missions supported hundreds of experiments aboard the orbiting laboratory. 

It also averted a disaster in July when thrusters of a newly-arrived Russian research module, called Nauka, inadvertently fired a few hours after it docked.  

On November 11, NASA launched Crew 3, the third fully-fledged ‘operational’ crew NASA and SpaceX have flown to the ISS. The crew successfully reached the ISS about a day after the launch. 

Crew 3 marked the fourth crew NASA has launched to orbit aboard a SpaceX vehicle in 17 months, building on a public-private partnership with SpaceX, the private company formed in 2002 by Elon Musk.

SPACEX-NASA SPACE MISSIONS TO THE ISS

Crew 3 is the third full-fledged ‘operational’ crew NASA and SpaceX have flown to the ISS

SpaceX Crew-1 (launched November 2020)

SpaceX Crew-2 (April 2021)

SpaceX Crew-3 (November 2021)

There were also two test missions to the ISS, one crewed and the other uncrewed:

Crew Dragon Demo-2 (crewed, May 2020)

Crew Dragon Demo-1 (uncrewed, March 2019) 

Multiple commercial resupply missions carried new science experiments and supplies to the orbiting laboratory throughout the year, including the SpaceX cargo Dragon spacecraft on the company’s 23rd commercial resupply mission for NASA (pictured here)

Aerospace company Northrop Grumman’s 16th Cygnus commercial resupply mission, which launched in August this year, is pictured here

Their collaboration helped usher in a new era for NASA leading to last year’s first launch of American astronauts from US soil in nine years, since it quit flying space shuttles in 2011. 

In May 2020, SpaceX successfully transported NASA astronauts Robert Behnken and Douglas Hurley on a 19-hour journey to the ISS – marking the first crewed test flight of the firm’s Crew Dragon spacecraft. 

In the process it became be the first crewed launch from the US into orbit since NASA’s space shuttle program ended in a decade ago. 

Crew 4 – the fourth crewed operational NASA flight of a Crew Dragon spacecraft – is set to launch on April 15, 2022. 

It will carry a four-person crew to the ISS – NASA astronauts Robert Hines, Kjell N. Lindgren and Jessica Watkins, as well as Italian ESA astronaut Samantha Cristoforetti. 

NASA astronaut Shane Kimbrough is pictured inside the Kibo laboratory module with the Astrobee free-flying robotic assistants. He monitored the cube-shaped robotic free-flyers as they tested automated rendezvous techniques

Members of the cold stowage team unpack the Rotifer-B2 science experiment inside the Space Station Processing Facility at NASA’s Kennedy Space Center in Florida on January 14, 2021. The experiment returned from station to Earth on SpaceX’s 21st commercial resupply services mission

NASA astronaut Mark Vande Hei works to relocate the Multi-use Variable-g Platform (MVP) inside the Kibo laboratory module. The MVP is a space biology research platform that can produce up to 2g of artificial gravity and houses samples such as fruit flies, flatworms, plants, fish, cells, protein crystals and more

NASA astronaut Shane Kimbrough and cosmonaut Oleg Novitskiy of Roscosmos unpack hardware for installation inside the U.S. Destiny laboratory module’s Microgravity Science Glovebox (MSG)

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High-resolution lab experiments show how cells ‘eat’

Credit: CC0 Public Domain

A new study shows how cell membranes curve to create the “mouths” that allow the cells to consume things that surround them.

“Just like our eating habits basically shape anything in our body, the way cells ‘eat’ matters for the health of the cells,” said Comert Kural, associate professor of physics at The Ohio State University and lead author of the study. “And scientists did not, until now, understand the mechanics of how that happened.”

The study, published last month in the journal Developmental Cell, found that the intercellular machinery of a cell assembles into a highly curved basket-like structure that eventually grows into a closed cage. Scientists had previously believed that structure began as a flat lattice.

Membrane curvature is important, Kural said: It controls the formation of the pockets that carry substances into and out of a cell.

The pockets capture substances around the cell, forming around the extracellular substances, before turning into vesicles—small sacs one-one millionth the size of a red blood cell. Vesicles carry important things for a cell’s health—proteins, for example—into the cell. But they can also be hijacked by pathogens that can infect cells.

But the question of how those pockets formed from membranes that were previously believed to be flat had stymied researchers for nearly 40 years.

“It was a controversy in cellular studies,” Kural said. “And we were able to use super-resolution fluorescence imaging to actually watch these pockets form within live cells, and so we could answer that question of how they are created.

“Simply put, in contrast to the previous studies, we made high-resolution movies of cells instead of taking snapshots,” Kural said. “Our experiments revealed that protein scaffolds start deforming the underlying membrane as soon as they are recruited to the sites of vesicle formation.”

That contrasts with previous hypotheses that the protein scaffolds of a cell had to go through an energy-intensive reorganization in order for the membrane to curve, Kural said.

The way cells consume and expel vesicles plays a key role for living organisms. The process helps clear bad cholesterol from blood; it also transmits neural signals. The process is known to break down in several diseases, including cancer and Alzheimer’s disease.

“Understanding the origin and dynamics of membrane-bound vesicles is important—they can be utilized for delivering drugs for medicinal purposes, but at the same time, hijacked by pathogens such as viruses to enter and infect cells,” Kural said. “Our results matter, not only for our understanding of the fundamentals of life, but also for developing better therapeutic strategies.”

Emanuele Cocucci, an assistant professor in Ohio State’s College of Pharmacy, co-authored this study, along with researchers from UC Berkeley, UC Riverside, Iowa State University, Purdue University and the Chinese Academy of Sciences.


Not as simple as thought: How bacteria form membrane vesicles


More information:
Nathan M. Willy et al, De novo endocytic clathrin coats develop curvature at early stages of their formation, Developmental Cell (2021). DOI: 10.1016/j.devcel.2021.10.019
Provided by
The Ohio State University

Citation:
High-resolution lab experiments show how cells ‘eat’ (2021, December 30)
retrieved 31 December 2021
from https://phys.org/news/2021-12-high-resolution-lab-cells.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



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