Tag Archives: endemic

Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases – Science

  1. Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases Science
  2. SARS-CoV-2, the virus behind COVID-19, can infect sensory neurons Medical Xpress
  3. Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC News-Medical.Net
  4. Study characterizes SARS-CoV-2 Omicron BA.2.86: New variant under watch News-Medical.Net
  5. Researchers characterize new SARS-CoV-2 BA.2.86 variant neutralization by monoclonal antibodies News-Medical.Net
  6. View Full Coverage on Google News

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Leprosy could be endemic in Central Florida, CDC says. What to know about the disease. – CBS News

  1. Leprosy could be endemic in Central Florida, CDC says. What to know about the disease. CBS News
  2. Biblical disease spikes in Florida: CDC’s leprosy alert New York Post
  3. Florida is experiencing an increase in LEPROSY cases with nearly 20% of cases across the country coming from t Daily Mail
  4. Urgent warning over ‘medieval’ leprosy that causes blindness and paralysis as cases DOUBLE… The US Sun
  5. Leprosy: Case report suggest disease is becoming endemic in central Florida – Outbreak News Today Outbreak News Today
  6. View Full Coverage on Google News

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Melioidosis: B. pseudomallei that causes illness is endemic in parts of Mississippi Gulf Coast, CDC says

Burkholderia pseudomallei was found in the Gulf Coast region of Mississippi, the first detection of the bacteria in the environment in the US.

“It is unclear how long the bacterium has been in the environment prior to 2020 or how widespread the bacterium is in the continental United States; modeling suggests that the environmental conditions found in the Gulf Coast states are conducive to the growth of B. pseudomallei,” the CDC said in a Health Alert Network Advisory.

The agency asked health care providers across the country to consider melioidosis as a possible diagnosis when people have symptoms, “as melioidosis is now considered to be locally endemic in areas of the Gulf Coast region of Mississippi.

Symptoms of melioidosis depend on where someone is infected but may include fever, pain or swelling, ulcers, coughing, chest pain, trouble breathing, weight loss, muscle or joint pain, disorientation, headache and seizures. These can progress to conditions such as pneumonia, abscesses and blood infections. It’s deadly in 10% to 50% of cases.

B. pseudomallei is typically found in tropical regions, and US cases are usually connected to travel. The CDC says an average of 12 cases are reported to the agency each year.

The latest discovery came about after two people who lived close to each other in southern Mississippi but who had no recent history of international travel were diagnosed with the same bacterial strain in July 2020 and May 2022, the CDC said, prompting sampling of their household products, their properties and nearby areas. The patients were hospitalized but recovered after taking antibiotics.

The risk to the general population in the US “continues to be very low,” the agency said in a news release, and there are few documented cases of person-to-person transmission.

People who live in or visit coastal Mississippi, especially those with certain chronic conditions, are urged to protect open wounds, cuts or burns with waterproof bandages; avoid contact with soil or muddy water; and do not drink water from shallow wells, lakes, rivers, ponds and streams. Get medical care right away if you notice possible melioidosis symptoms.

Melioidosis was connected to contaminated aromatherapy sprays late last year. One person died of a B. pseudomallei infection in October that was traced to the sprays.

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Mayo Clinic: COVID-19 heading toward endemic

Two years after COVID-19 swept the globe and was declared a pandemic, outbreaks are waning again.

While COVID-19 is still a pandemic, Americans may start becoming familiar with a new word: endemic.

Hubbard Broadcasting sister station KAAL-TV spoke with Mayo Clinic officials, who said COVID-19 is on its way to becoming endemic.

“There is going to be a need for some sort of periodic vaccination. It’s something where we’re likely to see new variants,” Dr. Jack O’Horo, an infectious disease expert at Mayo Clinic, told KAAL.

Experts say there will likely be some variation in mitigation strategies, which could also fluctuate based on different surges.

“Just because it’s safe to take off a mask three counties over in one setting, doesn’t mean it’s safe to do the same in this county,” O’Horo said.

Mayo Clinic did tell KAAL that COVID-19 could reach the endemic phase and then move back into a pandemic again.

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Pennsylvania Ready To Move Towards Endemic Stage Of COVID-19, Acting Health Secretary Says – CBS Pittsburgh

By: KDKA-TV News Staff

PITTSBURGH (KDKA) – The Pennsylvania Department of Health said the state is moving towards the endemic stage of COVID-19.

READ MORE: New CDC Guidelines Drop Mask Recommendation For 70% Of Americans

Citing the state’s vaccination rate, Acting Health Secretary Keara Klinepeter said Pennsylvania is prepared to transition out of the pandemic phase. More than 76 percent of adults are fully vaccinated, and 95 percent of adults have gotten at least one dose, according to state data.

In addition to more vaccinations, Klinepeter said the key will be “a strong public health infrastructure.” Pennsylvania has built up a stockpile of PPE, increased testing and invested in hospitals and the health care workforce, Klinepeter said

READ MORE: John Mayer Postpones Pittsburgh Concert

“Moving forward does not mean ignoring COVID-19,” Klinepeter said. “We have the knowledge and tools needed to make smart decisions guided by public health research to keep ourselves and our communities safer. Our strategy includes a continued focus on prevention while being nimble enough to quickly respond to any changes in the COVID-19 landscape.”

She said an endemic won’t be declared until the World Health Organization announces it.

MORE NEWS: CDC To Significantly Ease Pandemic Mask Guidelines On Friday

Since the pandemic started, the state has reported over 2.2 million confirmed cases and more than 43,000 deaths.

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As COVID-19 becomes endemic, research finds infection can cause hearing loss, ringing in ears

Did you hear the news? COVID-19 cases are dropping, and everyday life is starting to return to normal.

But maybe you didn’t hear the news — because you’ve been exposed to COVID-19. A recently published study, led by Massachusetts Institute of Technology RNA-virus expert Lee Gehrke and Stanford University otolaryngologist Konstantina Stankovic, links coronavirus infection with hearing loss, ringing in the ears and other inner-ear problems.

“Our study showed evidence that the SARS-CoV-2 virus that causes COVID-19 can directly infect the inner ear,” Stankovic told a university publication.

This is no small thing, with the hearing loss and balance issues from inner-ear infection proving quite serious at times. But such problems often were overlooked at the height of the pandemic in 2020-21, Stankovic pointed out, as doctors focused on keeping acute COVID-19 patients alive.

“They weren’t paying much attention to whether [patients’] hearing was reduced or whether they had vertigo,” she said.

As the novel coronavirus now settles into an endemic stage, becoming less fatal and more manageable due to built-up immunity in the population and proven treatments, medical research will increasingly zero in on the lingering symptoms of those who have survived bouts of COVID-19. Research indicates that up to 40% of people who have recovered from the initial coronavirus infection continue to suffer for weeks or months from sometimes-debilitating symptoms, such as fatigue, muddled memory and joint pain. Hearing problems appear to fall into this category.

Researchers say that, in some cases, these various symptoms — known as “long COVID” — might prove to be permanent.

As for the COVID-19-related hearing issues, it’s not yet known how the virus gets into the inner ear. Stankovic speculates that it migrates there from the nose. She believes there’s little chance the virus makes its way into the body through the outer ear.

Another recent study, which focused on COVID-19 patients with mild symptoms who had no previous hearing disorders, found that “hearing loss in the COVID era is one of the emerging areas of concern.” Its authors, like Gehrke and Stankovic, recommend more research to allow for “better understanding and treatment.”

— Douglas Perry

dperry@oregonian.com

@douglasmperry



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Is it time to live with COVID-19? Some scientists warn of ‘endemic delusion’ | Science

As surges of COVID-19 cases driven by the highly infectious Omicron variant recede, parts of the United States, Canada, and Europe are moving swiftly to lift constraints on a pandemic-fatigued public. Sweden, Denmark, and Norway have abolished nearly all ­COVID-19–related restrictions in recent weeks, and the United Kingdom announced it would do the same this month, dropping even the legal requirement that people quarantine after testing positive for SARS-CoV-2. In the United States, despite persistently high numbers of COVID-19–related deaths and busy hospitals, 10 governors, many known for being cautious in their pandemic response, last week announced immediate or impending ends to their states’ indoor or school mask mandates.

Some of those moves came with assertions that it’s time to “live with the disease” and treat the coronavirus as endemic—a stable, enduring figure in the panoply of human pathogens, alongside cold viruses and influenza. That suggestion troubles many scientists, who warn it is eroding governments’ commitment to tracking and responding to the pandemic—which could leave countries flying blind and unprepared for any new variant.

“Endemic delusion is probably what captures it the best,” says Kristian Andersen, an infectious disease researcher at Scripps Research who has been especially critical of recent moves by his home country of Denmark, which include an announcement that as of this month COVID-19 would no longer be categorized as a “socially critical disease” even though related death and hospitalization rates were still climbing there.

Still, many scientists acknowledge the challenges of steering public restrictions during the reign of the more infectious but generally less severe Omicron variant, when some of the metrics that previously guided policy have become less informative. For example, how meaningful are case counts as mild and asymptomatic infections increase and unreported at-home tests become ubiquitous? How much do incidental findings of COVID-19 in patients hospitalized for other conditions pollute the official numbers?

“The challenge for each and every health authority is to figure out, well, what should we track?” says Michael Bang Petersen, a political scientist at Aarhus University.

Denmark’s recent moves are a case in point. Petersen, a pandemic adviser to the Danish government, supports its decision to lift measures such as limits on nightlife hours, caps on attendance at indoor public events, and mandatory face masks or proof of vaccination for indoor venues. He argues the government could no longer justify the economic, social, and constitutional trade-offs of those restrictions amid promising signs, such as numbers of intensive care unit (ICU) patients that remain stable and below the health system’s capacity.

Andersen, however, calls keeping hospitals from overflowing “a pretty low bar.” Bringing down overall cases, and thereby reducing transmission, remains key, he argues, to minimizing risks of Long Covid and protecting the elderly and immunocompromised from infection.

In the United States, governors cited various metrics to justify recent decisions to lift or let expire indoor mask mandates. California Governor Gavin Newsom noted stable hospitalization rates and a 65% reduction in cases since Omicron’s peak in announcing the state’s mandate would end this week. But leaders also face political and economic pressures. States’ moves may be driven largely by the public’s impatience with restrictions, says epidemiologist Dustin Duncan of Columbia University.

“Even people who recognize the importance of masking, social distancing, all that stuff, may be more amenable to take more risk,” he says. “At the same time, to me, going maskless just seems egregious.” Indeed, the U.S. Centers for Disease Control and Prevention has held firm in recommending masks for indoor public spaces in areas of high transmission—which is nearly all of the country.

“I do feel it is on the early side” to lift indoor mask requirements in most states, says Emory University epidemiologist Jodie Guest—though recommendations may be a better option than requirements as case numbers plummet, she adds.

Still, with the United States logging more than 2000 daily deaths last week, “We cannot say we are at a level that’s tolerable to live with this virus,” Guest says. Her team has been developing rough guidelines for when a true endemic stage of COVID-19 has been reached: daily case rates below 30 per 100,000, ICUs below 80% of capacity, vaccination rates of at least 75%, and fewer than 100 COVID-19 deaths a day nationwide.

Deciding when to end mask requirements in schools is especially difficult, in part because of continued (but hard to prove) concerns the coverings impede learning and social development. “If you ask a bunch of scientists, ‘Should kids wear face masks in school?’ you’re probably going to get a lot of disagreement,” Andersen notes, “and I don’t know who is right.”

Guest says she doesn’t have as clear a sense of the numerical thresholds that could determine when schools should stop mandating masks. “I would be hesitant [to remove requirements] right now,” she says, adding the step could soon be justified in parts of the country.

Data to inform such debates may become less available or reliable if governments pivot too soon to an endemic view of the coronavirus, scientists say. As pandemic restrictions in Denmark relax, “people are becoming less motivated to get tested and we are beginning to downscale our test system,” Petersen says.

Some governments are limiting efforts to find and report cases. Sweden, long an outlier among European countries for its laissez-faire approach to the pandemic, ended widespread testing at mobile centers as cases declined from their Omicron peak. The United Kingdom is reportedly weighing ending free public testing for the virus in the coming weeks. Meanwhile, the Canadian province of Saskatchewan last week switched from providing daily to weekly reports of COVID-19 cases. And Tennessee last month joined several states already reporting case counts weekly. “Daily case counts matter,” Guest says. “Every time I lose the ability to have a number, it makes me nervous.”

Official counts are already becoming less meaningful as the reliance on at-home test increases, making other surveillance approaches all the more important. Last week, researchers took to Twitter in outrage after a U.K. news report claimed the United Kingdom might not continue to fund a long-running study in which the Office for National Statistics (ONS) conducts repeated antibody surveys and SARS-CoV-2 testing of more than 100,000 randomly selected households. “What that’s meant is that you’ve had a way of seeing the prevalence in your population that does not depend on people accessing testing,” says Christina Pagel, a health services researcher at University College London.

Discontinuing the ONS study would also obscure data on asymptomatic cases, differences in disease burden between different ethnic and occupational groups, and the impact of Long Covid, Pagel says. She suspects the outcry will sway the U.K. government, which responded in the news report by saying no funding decision had been made and it “obviously” wanted to “maintain our world-leading surveillance capacity” for COVID-19.

But in the growing number of “back to normal” messages, Pagel sees leaders ignoring obvious next steps to protect public safety. Even researchers who aren’t speaking up to defend specific restrictions are urging governments to step up their COVID-19 fight, rather than scale it back. They want aggressive new pushes to reach the unvaccinated, distribute rapid tests, and make COVID-19 treatments much more accessible, for example. “Frankly, I don’t really think that 2 to 3 weeks more of a mask mandate is going to make much difference in the long run,” says KJ Seung, a health policy adviser at Partners In Health. “More alarming to me is that our public health system doesn’t seem to have any plan for dealing with the next surge.”

“I don’t particularly want to be in a future where I get COVID twice a year,” Pagel adds. Averting that future may mean adaptations such as technologies to improve indoor air quality and strong virus surveillance that can be ramped up at the first sign of another surge. “Why would we not make that effort?” she wonders. “It’s almost like having that conversation is considered a failure.”



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Covid will never become an endemic virus, scientist warns

JaruekChairak | iStock | Getty Images

Covid-19 will never become an endemic illness and will always behave like an epidemic virus, an expert in biosecurity has warned.

Raina MacIntyre, a professor of global biosecurity at the University of New South Wales in Sydney, told CNBC that although endemic disease can occur in very large numbers, the number of cases does not change rapidly as seen with the coronavirus.

“If case numbers do change [with an endemic disease], it is slowly, typically over years,” she said via email. “Epidemic diseases, on the other hand, rise rapidly over periods of days to weeks.”

Scientists use a mathematical equation, the so-called R naught (or R0), to assess how quickly a disease is spreading. The R0 indicates how many people will catch a disease from an infected person, with experts at Imperial College London estimating omicron’s could be higher than 3.  

If a disease’s R0 is greater than 1, growth is exponential, meaning the virus is becoming more prevalent and the conditions for an epidemic are present, MacIntyre said.

“The public health goal is to keep the effective R — which is R0 modified by interventions such as vaccines, masks or other mitigations — below 1,” she told CNBC. “But if the R0 is higher than 1, we typically see recurrent epidemic waves for respiratory transmitted epidemic infections.”

MacIntyre noted that this is the pattern that was seen with smallpox for centuries and is still seen with measles and influenza. It’s also the pattern unfolding with Covid, she added, for which we have seen four major waves in the past two years. 

“Covid will not magically turn into a malaria-like endemic infection where levels stay constant for long periods,” she argued. “It will keep causing epidemic waves, driven by waning vaccine immunity, new variants that escape vaccine protection, unvaccinated pockets, births and migration.”

“This is why we need an ongoing ‘vaccine-plus’ and ventilation strategy, to keep R below 1 so we can live with the virus without major disruptions to society,” MacIntyre said, adding a warning that “there will be more variants coming.”

Last week, the WHO warned that the next Covid variant will be even more contagious than omicron.

Global Biosecurity, the Twitter account representing a collective of UNSW research departments covering epidemics, pandemics and epidemiology, argued last year that Covid will continue to “display the waxing and waning pattern of epidemic diseases.”

“[Covid] will never be endemic,” the organization argued. “It is an epidemic disease and always will be. This means it will find unvaccinated or under-vaccinated people and spread rapidly in those groups.”

Pandemic, epidemic or endemic?

According to the U.S. Centers for Disease Control and Prevention, an epidemic occurs when the number of cases of a disease increases, often suddenly, above what is usually expected.

The WHO declares a disease a pandemic when its growth is exponential and it is spreading globally.

“While an epidemic is large, it is also generally contained or expected in its spread, while a pandemic is international and out of control,” experts from Columbia University’s Mailman School of Public Health explained in a blog post last year. “The difference between an epidemic and a pandemic isn’t in the severity of the disease, but the degree to which it has spread.”

Endemic disease is defined as “the constant presence or usual prevalence of a disease or infectious agent in a population within a geographic area” by the U.S. CDC.

For Covid to become endemic, enough people need to have immune protection from Covid for it to become endemic, according to the American Lung Association, highlighting the importance vaccination will play in the virus’ transition away from pandemic status.

WHO Director-General Tedros Adhanom Ghebreyesus said last week that there was a chance that Covid could be ended as a global health emergency this year if the right course of action — which includes addressing vaccine and health care inequity — is taken.

His comments came a week after another senior WHO official warned that “we won’t ever end the virus” and that “endemic does not mean ‘good,’ it just means ‘here forever.'”

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Pandemic versus Endemic: What the numbers tell us about Omicron

On Saturday, the World Health Organisation reported a staggering 3,652,595 new cases worldwide, a new record of new infections that we haven’t seen since the beginning of the coronavirus pandemic. Just a little bit more than a month ago, the daily average of new infection was under 300,000!

For the past week, the average has been well above the 2.5 million, almost 10 times November and December’s numbers. Scary stuff this Omicron, isn’t it?

Not so, scientists say. On the contrary, actually. Many of them, including the highest epidemic expert in the United States, say those numbers offer hope that we may be nearing the end of the pandemic. How so?

There seems to be a growing consensus, yet timid and slow, that we will never be able to get rid of the coronavirus but 2022 will be the year it will move from pandemic to endemic — meaning that it will continue to infect people, probably in bigger numbers, but will not disrupt life, just like the seasonal flu.

Doesn’t make sense still?

Let us look at the numbers. The infection numbers are exponentially higher than anything we have seen in the past two years. France, for example, reported an astonishing 460,000 cases on Wednesday, in a country with a population of 65 million.

Omicron has been doing the rounds with at least ten times higher transmission rate than its predecessor, Delta or the original Covid-19 virus. It is more contagious and quicker. Sure. But Anthony Fauci, the chief medical adviser to the US president, has a very different take on those numbers.

He says the hospitalisation numbers are “the more relevant marker of viral damage”, not the number of new cases. And so does the measure of success in containing the outbreak. It is no longer about reducing the number of daily cases but more about keeping people safe and the economy running.

A study published on January 12 by the US Centres for Disease Control and Prevention (CDC) that looked at data from 69,279 patients (52,297 with the Omicron variant, 16,982 with the Delta variant) between November 30, 2021, and January 1, 2022 in California gives more credence to that argument.

The study found that “Omicron cases resulted in 53 per cent less risk of hospitalisation, 74 per cent less risk of ICU admission, and 91 per cent less risk of death. The study also found that none of the patients with Omicron required mechanical ventilation.” Other studies conducted in South Africa, Hong Kong and other countries showed more or less similar encouraging results.

Almost no symptoms

I have had several friends and colleagues who tested positive in the past two weeks. The coronavirus infection is not what it once was, believe me. Apart from being bored because of the 10-day quarantine, their time was almost all spent on emails, social media and Netflix; they have had almost no symptoms. Probably some headache, a running nose and tiredness in the first two or three days. But that is all about it.

Medical experts now say the risk that a vaccinated adult will die of Omicron is lower than the risk of seasonal flu death, God forbid. So, what do we make of all these numbers?

Omicron, while certainly still a risk to those unvaccinated folks, might actually be the acrimonious development, the bitter pill the world has been waiting for to get rid of the pandemic. More and more experts are becoming convinced that both the symptoms and the hospitalisation numbers of Omicron offer hope that we might be moving from a state of pandemic to a state of endemic.

WHO defines a pandemic as a virus that has exponential growth of infection “covering a wide area, affecting several countries and populations”.

An endemic, meanwhile, is “a disease outbreak that is consistently present but limited to a particular region. This makes the disease spread and rates predictable”, according to the organisation’s website.

Malaria, for example, is considered an endemic in certain countries and regions. Its growth rate, however, is very limited to specific area and health prerequisites.

A good part of the solution

In less medical terms, pandemics are scary disruptive thing. Endemics, on the other hand, are viruses that we have been living with for thousands of years. The seasonal flu is endemic.

It is sometimes deadly but predictable. We have the required medicine for it, and life goes on. Thus the coronavirus, even though it still is a problem, has become a good part of the solution. The more people infected with Omicron, experts believe, the faster we reach herd immunity.

It is unlikely we will be able to completely eradicate Covid-19. That never happened, ever. Few decades ago, the world celebrated the eradication of smallpox. But from time to time, we hear of reports of its resurgence somewhere. But few people believe we can do that with Covid-19.

Thus, scientists are hopeful that with the nature of Omicron — its symptoms and health impact, we may be onto something close to be able to live with it, meaning Covid-19 may be becoming more of an endemic than a pandemic — a virus that will not disrupt life, will not close schools, shut business, ground aeroplanes or crash financial markets.

The skyrocketing oil prices is being considered as a validation of this theory. And that most probably explains why world governments keep telling us that lockdowns are now something of the past.

Let us hope 2022 is the year we move from pandemic to endemic.

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Goodbye Pandemic, Hello Endemic

Commentary

In early 1918, when World War I entered its final year, the H1N1 influenza A virus infected millions of people, causing the Spanish flu pandemic. By April 1920, after four waves and almost 100 million deaths, the pandemic ended. H1N1 became much less deadly and caused only ordinary seasonal flu. It had become an endemic virus.

Will history repeat itself? After two years of the COVID-19 pandemic and four waves of different variants, will SARS-CoV-2 become an endemic virus?

Looking Good

After my recent opinion piece “Omicron May Help End the Pandemic This Winter” was published, readers asked if I could cite peer-reviewed publications to support my pandemic-ending claim. Well, as the Omicron wave is still ongoing, my projection can only be as good as an educated prediction. But things are looking pretty good.

In the past week, there have been a few related research works published that point in the same direction—that Omicron is fast-spreading but less pathogenic. None of them are yet peer reviewed, and that’s because this data is time-sensitive and so scientists choose to allow the public access to their research “live,” as the peer review process takes time.

So what does the new data suggest? Could the spread of Omicron end the pandemic? Well, waves come and go. In order for Omicron to be the last wave, it needs to be able to stimulate strong and long-lasting immunity against potential future variants.

T Cell Immunity and Vaccination

The hope for long-lasting immunity relies on protective T cell responses. In my previous article I quoted a University of Cape Town study showing that long-lasting T cell response, induced either by vaccination or natural infection, cross-recognizes Omicron. The authors concluded that well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19 caused by other variants.

It turns out that not all T cell responses are the same, however. The Cape Town study did not distinguish the types of T cell responses a natural infection induces versus that of vaccination. We now know that although vaccinations with S protein-based vaccines stimulate T cell responses, the responses do not induce protection. That is why, even though the world had a high vaccination rate in November, the Omicron wave still arrived.

Stronger Protection

On Jan. 10, the scientific journal Nature published a peer-reviewed article titled “Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts.” Submitted to Nature by Imperial College London scientists five months ago, the article looked at T cell epitopes (very small protein fragments) from different SARS-CoV-2 proteins (S, N, E, and ORF1) in terms of their cross-reactivity to those of other species of human coronavirus OC-43 and HKU1, which cause the common cold.

They found a pool of T cell epitopes from S, N, and ORF1 proteins that were cross-reactive between SARS-CoV-2 and human coronavirus (huCoV). However, the specific T cell response that induces protection is from the epitopes of the N and ORF1 proteins, not the S protein (spike protein). They then concluded that in the second generation of vaccines developed against COVID-19, non-spike proteins should be included.

When I read the paper, I was less interested in the scientists’ recommendation on next-generation vaccine development than I was in their study of the non-spike proteins (N and ORF1) and their T cell epitopes’ cross-reactivity between SARS-CoV-2 and huCoVs, as this new information could shed light on detailed T cell immunity cross-protection between SARS-CoV-2 and huCoVs.

In other words, if the N-protein epitopes from the common cold could induce long-term protective T cell immunity against SARS-CoV-2, then Omicron infection with plenty of N-protein epitopes should also be able to induce similar T cell immunity and provide stronger protection against any future SARS-CoV-2 variant infections.

If you can recognize a distant cousin in a crowd, you can certainly spot your brother right next to you.

Light at the End of the Tunnel

For about a year now, scientists have been discussing the potential of SARS-CoV-2 to join the other four human coronaviruses as an endemic virus.

SARS-CoV-2 is the seventh coronavirus that infects humans. We have MERS-CoV causing Middle East respiratory syndrome, SARS-CoV and SARS-CoV-2 causing severe acute respiratory syndrome, and the remaining four (OC43, HKU1, 229E, and NL63) endemic viruses that cause the common cold.

In a peer-reviewed paper titled “Immunological characteristics govern the transition of COVID-19 to endemicity” published in the prestigious journal Science in February 2021, scientists at Pennsylvania State University and Emory University stated that all human coronaviruses elicit immunity with similar characteristics. The COVID-19 pandemic is a consequence of a human population that had not seen SARS-CoV-2 before. Once widespread infection (such as the Omicron wave) occurs across the world, the virus will eventually circulate endemically, meaning that infections may still happen but with milder symptoms and much less mortality.

There are two reasons that the transition from pandemic to endemic did not happen until Omicron: 1) all the widely used vaccines are based on the spike protein, which does not induce protective long-lasting T cell response, and 2) natural immunity was not widespread.

The Nature paper disclosed that protective (IL-2 secreting) T cells are induced by SARS-CoV-2 infection. Accordingly, we could foresee that a wider spread of Omicron infection would induce a wider range of cross-reactive T cell immunity, subsequently offering more widespread protection against potential future SARS-CoV-2 variants. As a result, we are likely very close to being able to say goodbye to the pandemic.

Although we should be mindful that we’re not out of the woods yet and people are still suffering, I remain optimistic that we are beginning to see the light at the end of the tunnel.

We also must remember that even when we say goodbye to COVID-19, we probably won’t be completely free of SARS-CoV-2. Even the seasonal flu kills more than half a million people globally every year, according to the World Health Organization. And another endemic virus will likely increase the burden on health systems around the world.

The good thing is, as I noted in my previous article, Omicron can be viewed as a live attenuated vaccine, which enjoys a very good track record among all vaccines. There have been about 11 diseases that attenuated vaccines were widely used to combat, such as measles, mumps, chickenpox, and polio. So far, none of these diseases have spread out of control after decades of vaccination.

Hopefully, Omicron will act like its other attenuated vaccine cousins, and with any luck no other SARS-CoV-2 variants will emerge and become a pandemic in the future.

Views expressed in this article are the opinions of the author and do not necessarily reflect the views of The Epoch Times.

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Joe Wang, Ph.D., was a lead scientist for Sanofi Pasteur’s SARS vaccine project in 2003. He is now the president of New Tang Dynasty TV (Canada), a media partner of The Epoch Times.

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