Tag Archives: detects

Could a New Test That Detects Dopamine Levels Help Diagnose Neurological Diseases?

Summary: A new test that measures dopamine levels in biological fluids could help with the detection of depression, Parkinson’s disease, and other disordered marked by abnormal dopamine levels.

Source: Wiley

Altered levels of the neurotransmitter dopamine are apparent in various conditions, such as Parkinson’s disease and depression.

In research published in ChemistrySelect, investigators describe a quick, sensitive, and simple test to determine dopamine levels in biological fluids.

The method could help clinicians spot abnormal blood levels of dopamine in patients, potentially allowing for earlier disease detection.

The method relies on what are called carbon quantum dots, a type of carbon nanomaterial with photoluminescence properties, and ionic liquid, which is comprised of several mineral anions and organic cations existing in liquid form at room temperature.

The method could help clinicians spot abnormal blood levels of dopamine in patients, potentially allowing for earlier disease detection. Image is in the public domain

“The proposed electrochemical sensor could be an exceptional step forward in dopamine detection and pave the way for the molecular diagnosis of neurological illnesses,” the authors wrote.

About this dopamine research news

Author: Sara Henning-Stout
Source: Wiley
Contact: Sara Henning-Stout – Wiley
Image: The image is in the public domain

Original Research: Open access.
“An Electrochemical Sensor Based on Carbon Quantum Dots and Ionic Liquids for Selective Detection of Dopamine” by Zahra Nazari et al. ChemicalSelect


Abstract

An Electrochemical Sensor Based on Carbon Quantum Dots and Ionic Liquids for Selective Detection of Dopamine

See also

Dopamine (DA) as a neurotransmitter has a pivotal role in the central nervous system. Because of altered levels of DA in various neuroscience diseases, development of a quick, sensitive, and simple analytical approach to determine DA in biological fluids could be very applicable.

In this research, a novel electrochemical sensor based on a carbon paste electrode (CPE) modified with ionic liquid (IL) and carbon quantum dots (CQDs) for measuring DA with uric acid and ascorbic acid was developed. IL and CQDs were synthesized and characterized for their specific properties such as composition, emission, size distribution, and morphology structure.

Then, the modified CPE and different DA concentration was determined via cyclic voltammetry. The modified electrode exhibited great electrocatalytic activity for DA oxidation.

Under optimal conditions, the calibration diagram for DA was linear within the range of 0.1–50 μM in phosphate buffer (pH=7.4) and limit of detection was 0.046 μM. The electrode was successfully used in the determination of DA in real samples and generated acceptable outputs.

The proposed electrochemical sensor could be an exceptional step forward in DA detection and pave the way for the molecular diagnosis of neurological illnesses.

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Massachusetts detects troubling new strain of gonorrhea

“We are getting close to an era where [patients] may no longer respond” to the drug, said Dr. Katherine Hsu, medical director of the division of STD Prevention and HIV/AIDS at the Massachusetts Department of Public Health.

The discovery comes as sexually transmitted infections, especially gonorrhea, are soaring nationwide, and the ability of many microbes to outsmart the drugs used to kill them is a growing worry.

“We are down to very few – very few – options. The concern is we’ll get to a place where there are no options,” said Dr. Helen Boucher, chief academic officer of the Tufts Medicine health system and a member of the Presidential Advisory Council on Combating Antibiotic Resistant Bacteria. “This is a common infection in young healthy people. … There’s only one thing, and that one thing may not work any more.”

Dr. Ruanne Barnabas, chief of the Division of Infectious Diseases at Massachusetts General Hospital, called the strain’s discovery “significant.”

“But given how mobile we are as a global community, it is not surprising,” she said.

The Massachusetts news should serve as a heads-up to doctors and patients to take gonorrhea seriously and watch for signs of resistance, said Dr. Laura Bachmann, chief medical officer of the CDC’s Division of STD Prevention.

The Centers for Disease Control and Prevention and state health officials both sent alerts to providers Thursday afternoon. The Massachusetts alert said the finding is a warning that gonorrhea “is becoming less responsive to a limited arsenal of antibiotics.”

“The message to providers is, ‘hey, we’ve got to keep an eye on this,’” Bachmann said. “Antimicrobial resistance is an important and urgent public health threat.”

Still, the CDC has not changed its recommendations for testing and treatment of gonorrhea. Bachmann called it “reassuring” that both Massachusetts patients were cured with standard treatment, a one-time injection of ceftriaxone.

The strain is circulating in the Asia-Pacific region, and 10 cases were recently identified in the United Kingdom. The UK patients were also cured with ceftriaxone.

Should ceftriaxone stop working, there are alternative drugs but they have greater risks, or are less effective, doctors say.

“We want to maintain the options we have,” Barnabas said.

She added that a potential vaccine is in development.

A few new antibiotics that might work are also in the pipeline but “economic realities” have slowed progress, with companies that work on them going out of business, Boucher said.

Gonorrhea is a common and fast-spreading sexually transmitted infection. Its incidence increased 45 percent from 2016 to 2020, and more than half of those infected are between the ages of 15 and 24. In Massachusetts, laboratory-confirmed cases of gonorrhea have quadrupled from a low of 1,976 cases in 2009 to 8,133 in 2021. The bacteria that cause it infect the mucous membranes of the reproductive tract and the urethra in women and men, as well as the mouth, throat, eyes, and rectum.

In many cases, infected people have no symptoms, which is why the CDC recommends screening tests for sexually active people. When symptoms do occur, they can include painful urination and urethral or vaginal discharge.

If it goes untreated, gonorrhea can lead to pelvic inflammatory disease and infertility in women, and inflammation in the scrotum of men. In time it can spread to the blood and cause inflammation of tendons, joints, the brain or the heart.

The Massachusetts cases were discovered as part of a routine testing process. A primary care doctor conducted a standard test to identify gonorrhea and also had the sample cultured. After the culture identified the infection as gonorrhea, an isolate of the organism was sent to the State Laboratory, which performed further testing for drug resistance.

The sample showed signs of resistance, so the state sent it to the CDC for more advanced testing, which identified the worrisome genetic pattern: the bacteria were resistant to ciprofloxacin, penicillin, and tetracycline and had reduced susceptibility to ceftriaxone, cefixime, and azithromycin.

That prompted the health department to ask clinical laboratories in the same region to send it additional samples from around the same time period. Further testing at the CDC turned up the second case.

Health officials found no connection between the two cases, and Barnabas said there are surely more than two people infected with the new strain. But there is no information to indicate how widespread the new bug may be. A similar strain that was not quite as resistant was identified in Nevada in 2019 but never seen again.

“We cannot be sure without scaling up on our surveillance efforts,” Hsu said, and now is “pivotal proactive moment for public health.”

It’s possible that the strain is circulating elsewhere, Bachmann said. “This is why it’s so important for providers to have on their radar and public health departments to keep an eye out for treatment failures.”

“To prevent resistance,” Bachmann said, “it’s really important to identify gonorrhea quickly and treat it appropriately with the right drug at the right time and the right amount. That requires providers to be in tune to screening guidelines and appropriate treatment.”

The Massachusetts health department is asking providers to treat gonorrhea with high doses of ceftriaxone, perform cultures from symptomatic gonorrhea cases and follow protocols for submitting samples to the state lab, and test to make sure patients are cured after treatment. Additionally regular screening is recommended for sexually active women ages 24 and younger, women who are at increased risk, and sexually active men who have sex with men.

As for what individuals can do, Public Health Commissioner Margret Cooke offered this advice in a statement: “We urge all sexually active people to be regularly tested for sexually transmitted infections and to consider reducing the number of their sexual partners and increasing their use of condoms when having sex.”


Felice J. Freyer can be reached at felice.freyer@globe.com. Follow her on Twitter @felicejfreyer.



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Hubble Detects Mysterious Ghostly Glow Surrounding Our Solar System 

This artist’s illustration shows the location and size of a hypothetical cloud of dust surrounding our solar system. Credit: NASA, ESA, Andi James (STScI)

Exhaust from Infalling Comets Makes Space a Dusty Place

Imagine walking into a room at night, turning off all the lights, and closing the shades. Yet an eerie glow comes from the walls, ceiling, and floor. The faint light is barely enough to see your hands before your face, but it persists.

Sounds like a scene out of “Ghost Hunters?” No, for astronomers this is the real deal. However, looking for something that’s close to nothing is not easy. Astronomers searched through 200,000 archival images from Hubble Space Telescope and made tens of thousands of measurements on these images to look for any residual background glow in the sky. Like turning out the lights in a room, they subtracted the light from stars, galaxies, planets, and even the zodiacal light. (Zodiacal light is a faint glow of diffuse sunlight scattered by interplanetary dust.) Surprisingly, a ghostly, feeble glow was left over. It’s equivalent to the steady light of ten fireflies spread across the entire sky.

Where’s that coming from?

One possible explanation is that a shell of dust envelops our solar system all the way out to

This artist’s illustration shows the location and size of a hypothetical cloud of dust surrounding our solar system. Astronomers searched through 200,000 images and made tens of thousands of measurements from Hubble Space Telescope to discover a residual background glow in the sky. Because the glow is so smoothly distributed, the likely source is innumerable comets – free-flying dusty snowballs of ice. They fall in toward the Sun from all different directions, spewing out an exhaust of dust as the ices sublimate due to heat from the Sun. If real, this would be a newly discovered architectural element of the solar system. Credit: NASA, ESA, Andi James (STScI)

Hubble Space Telescope Detects Ghostly Glow Surrounding Our Solar System 

Aside from a tapestry of glittering stars, and the glow of the waxing and waning Moon, the nighttime sky looks inky black to the casual observer. But how dark is dark?

To find out, astronomers decided to sort through 200,000 images from

This photo shows the zodiacal light as it appeared on March 1, 2021, in Skull Valley, Utah. The Pleiades star cluster is visible near the top of the light column. Mars is just below that. Credit: NASA/Bill Dunford

The researchers say that one possible explanation for this residual glow is that our inner solar system contains a tenuous sphere of dust from comets that are falling into the solar system from all directions, and that the glow is sunlight reflecting off this dust. If real, this dust shell could be a new addition to the known architecture of the solar system.

This idea is bolstered by the fact that in 2021 another team of astronomers used data from NASA’s New Horizons spacecraft to also measure the sky background. New Horizons flew by Pluto in 2015, and a small Kuiper belt object in 2018, and is now heading into interstellar space. The New Horizons measurements were done at a distance of 4 billion to 5 billion miles from the Sun. This is well outside the realm of the planets and asteroids where there is no contamination from interplanetary dust.

New Horizons detected something a bit fainter that is apparently from a more distant source than Hubble detected. The source of the background light seen by New Horizons also remains unexplained. There are numerous theories ranging from the decay of dark matter to a huge unseen population of remote galaxies.

“If our analysis is correct there’s another dust component between us and the distance where New Horizons made measurements. That means this is some kind of extra light coming from inside our solar system,” said Tim Carleton, of Arizona State University (ASU).

“Because our measurement of residual light is higher than New Horizons we think it is a local phenomenon that is not from far outside the solar system. It may be a new element to the contents of the solar system that has been hypothesized but not quantitatively measured until now,” said Carleton.

Hubble veteran astronomer Rogier Windhorst, also of ASU, first got the idea to assemble Hubble data to go looking for any “ghost light.” “More than 95% of the photons in the images from Hubble’s archive come from distances less than 3 billion miles from Earth. Since Hubble’s very early days, most Hubble users have discarded these sky-photons, as they are interested in the faint discrete objects in Hubble’s images such as stars and galaxies,” said Windhorst. “But these sky-photons contain important information which can be extracted thanks to Hubble’s unique ability to measure faint brightness levels to high precision over its three decades of lifetime.”

A number of graduate and undergraduate students contributed to project SKYSURF, including Rosalia O’Brien, Delondrae Carter and Darby Kramer at ASU, Scott Tompkins at the University of Western Australia, Sarah Caddy at Macquarie University in Australia, and many others.

The team’s research papers are published in The Astronomical Journal and The Astrophysical Journal Letters.

References:

“SKYSURF: Constraints on Zodiacal Light and Extragalactic Background Light through Panchromatic HST All-sky Surface-brightness Measurements: II. First Limits on Diffuse Light at 1.25, 1.4, and 1.6 µm” by Timothy Carleton, Rogier A. Windhorst, Rosalia O’Brien, Seth H. Cohen, Delondrae Carter, Rolf Jansen, Scott Tompkins, Richard G. Arendt, Sarah Caddy, Norman Grogin, Scott J. Kenyon, Anton Koekemoer, John MacKenty, Stefano Casertano, Luke J. M. Davies, Simon P. Driver, Eli Dwek, Alexander Kashlinsky, Nathan Miles, Nor Pirzkal, Aaron Robotham, Russell Ryan, Haley Abate, Hanga Andras-Letanovszky, Jessica Berkheimer, Zak Goisman, Daniel Henningsen, Darby Kramer, Ci’mone Rogers and Andi Swirbul, 4 October 2022, The Astronomical Journal.
DOI: 10.3847/1538-3881/ac8d02

“SKYSURF: Constraints on Zodiacal Light and Extragalactic Background Light through Panchromatic HST All-sky Surface-brightness Measurements. I. Survey Overview and Methods” by Rogier A. Windhorst, Timothy Carleton, Rosalia O’Brien, Seth H. Cohen, Delondrae Carter, Rolf Jansen, Scott Tompkins, Richard G. Arendt, Sarah Caddy, Norman Grogin, Anton Koekemoer, John MacKenty, Stefano Casertano, Luke J. M. Davies, Simon P. Driver, Eli Dwek, Alexander Kashlinsky, Scott J. Kenyon, Nathan Miles, Nor Pirzkal, Aaron Robotham, Russell Ryan, Haley Abate, Hanga Andras-Letanovszky, Jessica Berkheimer, John Chambers, Connor Gelb, Zak Goisman, Daniel Henningsen, Isabela Huckabee, Darby Kramer, Teerthal Patel, Rushabh Pawnikar, Ewan Pringle, Ci’mone Rogers, Steven Sherman, Andi Swirbul and Kaitlin Webber, 15 September 2022, The Astronomical Journal.
DOI: 10.3847/1538-3881/ac82af

“SKYSURF-3: Testing Crowded Object Catalogs in the Hubble eXtreme Deep Field Mosaics to Study Sample Incompleteness from an Extragalactic Background Light Perspective” by Darby M. Kramer, Timothy Carleton, Seth. H. Cohen, Rolf Jansen, Rogier A. Windhorst, Norman Grogin, Anton Koekemoer, John W. MacKenty and Nor Pirzkal, 18 November 2022, The Astronomical Journal Letters.
DOI: 10.3847/2041-8213/ac9cca

“SKYSURF-4: Panchromatic Full Sky Surface Brightness Measurement Methods and Results” by Rosalia O’Brien, Timothy Carleton, Rogier A. Windhorst, Rolf A. Jansen, Delondrae Carter, Scott Tompkins, Sarah Caddy, Seth H. Cohen, Haley Abate, Richard G. Arendt, Jessica Berkheimer, Annalisa Calamida, Stefano Casertano, Simon P. Driver, Connor Gelb, Zak Goisman, Norman Grogin, Daniel Henningsen, Isabela Huckabee, Scott J. Kenyon, Anton M. Koekemoer, Darby Kramer, John Mackenty, Aaron Robotham and Steven Sherman, 13 October 2022, Astrophysics > Instrumentation and Methods for Astrophysics.
arXiv:2210.08010

The Hubble Space Telescope is a project of international cooperation between NASA and ESA. NASA’s Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Maryland, conducts Hubble and Webb science operations. STScI is operated for NASA by the Association of Universities for Research in Astronomy, in Washington, D.C.