Tag Archives: COVID-19

Beds run out at Beijing hospital as COVID-19 spreads

BEIJING (AP) — Patients, mostly older people, laid on stretchers in hallways or took oxygen while sitting in wheelchairs as a COVID-19 outbreak stretched public health facilities’ resources in China’s capital Beijing, even after its reported peak.

The Chuiyangliu hospital in the city’s east was packed Thursday with newly arrived patients. Beds ran out by midmorning, even as ambulances continued to bring more people in. Hard-pressed nurses and doctors rushed to take information and triage the most urgent cases.

The crush of people seeking hospital care follows China abandonment of its most severe pandemic restrictions last month after nearly three years of lockdowns, travels bans and school closures that weighed heavily on the economy and prompted unusual street protests in a country that quashes political dissent.

The outbreak appears to have spread the fastest in densely populated cities first. Now, authorities are concerned as it reaches smaller towns and rural areas with weaker health care systems. Several local governments began asking people Thursday not to make the trip home for the upcoming Lunar New Year holiday, signaling lingering worry around opening up.

Overseas, a growing number of governments are requiring virus tests for travelers from China, saying they are needed because the Chinese government is not sharing enough information on the outbreak. The European Union on Wednesday “strongly encouraged” its member states to impose pre-departure COVID-19 testing, though not all have done so.

Italy — the first place in Europe where the pandemic exacted a heavy toll in early 2020 — became the first EU member to require tests for passengers from China last week, and France and Spain followed with their own measures. That followed the imposition by the U.S. of a requirement for a negative test result within 48 hours of departure.

China has criticized the requirements and warned of countermeasures against countries imposing them.

World Health Organization head Tedros Adhanom Ghebreyesus said Wednesday he was concerned about the lack of outbreak data from the Chinese government.

At a daily briefing Thursday, Chinese Foreign Ministry spokesperson Mao Ning said Beijing has consistently “shared information and data with the international community in an open and transparent manner.”

“At present, China’s COVID-19 situation is under control,” Mao said. “Also, we hope that the WHO secretariat will take a science-based, objective and impartial position to play a positive role in addressing the pandemic globally.”

Local government appeals to avoid travel during the Lunar New Year holiday comes days before the formal lifting of many remaining restrictions — some already not being enforced — on Sunday.

“We recommend that everyone not return to their hometowns unless necessary during the peak of the outbreak,” the government of Shaoyang county in Hunan province in central China said in a notice dated Thursday. “Avoid visiting relatives and traveling between regions. Minimize travel.”

Similar appeals were issued by Shouxian county in Anhui province southeast of Beijing and the cities of Qingyang in Gansu province in the northwest and Weifang in Shandong on the east coast.

The appeals, which harkened back to the last few years of strict pandemic restrictions, showed that some officials remain nervous about lifting them too quickly.

The Weifang government notice said residents should celebrate the holiday with video and phone gatherings.

“Avoid visiting relatives and friends to protect yourself and others,” it said.

Despite such concerns, Hong Kong announced it will reopen some of its border crossings with mainland China on Sunday and allow tens of thousands of people to cross every day without being quarantined.

The city’s land and sea border checkpoints with the mainland have been largely closed for almost three years and the reopening is expected to provide a much-needed boost to Hong Kong’s tourism and retail sectors.

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Associated Press reporters Joe McDonald in Beijing and Kanis Leung in Hong Kong contributed to this report.

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Why Do You Get Sick in the Winter? Blame Your Nose

To figure out what exactly was causing this antiviral capability, the scientists then incubated the vesicles with the viruses and imaged them under a microscope. They found that the viruses got stuck to receptors on the vesicles’ surface—trapping them and rendering them incapable of infecting cells. In other words, the vesicles were acting as a kind of decoy. “Because the same receptors are on the vesicles as are on the cells, most of the viruses get bound to the vesicle and killed before they ever get to the cells,” Bleier says. 

In addition, the scientists also found that the stimulated vesicles contained higher quantities of microRNA—small strands of RNA—previously known to have antiviral activity.

Finally, the scientists wanted to see how a small temperature change might affect the quality and quantity of the secreted vesicles. To create a dish-based mimic of the human nose, they used small pieces of mucosal tissue extracted from a few patients’ noses and placed those little tissues, known as explants, into cell culture. Then they lowered the temperature from 37 to 32 degrees Celsius, stimulated the tissue to upregulate TLR3, and collected the secreted vesicles.

They found that the cold caused a 42 percent drop in the tissues’ ability to secrete vesicles, and those vesicles had 77 percent fewer of the receptors that would let them bind to and neutralize a virus. “Even in that 5-degree drop for 15 minutes, it resulted in a really dramatic difference,” Amiji says. 

Noam Cohen, an otorhinolaryngologist at the University of Pennsylvania, says that this work sheds light on the mechanics of how viruses spread more easily in cold weather. (Cohen was unaffiliated with this work, but previously mentored Bleier when he was a medical student.) “What this paper is demonstrating is that viruses, even though they’re incredibly simplistic, are incredibly crafty,” he says. “They’ve optimized a cooler temperature to replicate.”  

Jennifer Bomberger, a microbiologist and immunologist at Dartmouth College, says that one of the study’s interesting points was how the “vesicles weren’t just immune-education,” meaning they weren’t just ferrying immune system instructions. Instead, she continues, “they were actually carrying out some of the actual antiviral effects themselves by binding to the virus.” She notes, though, that looking at mucus from patients with real infections (rather than using a virus-mimic) might provide additional insights into how these vesicles work.

The behavior of these vesicles isn’t the only reason why upper respiratory infections peak during the wintertime. Previous work has shown that colder temperatures also diminish the work of immune system antiviral molecules called interferons. Viruses also tend to spread as people move indoors. Social distancing during the pandemic has also potentially left people with less built-up immunity to the viruses that cause the flu and RSV, both part of the “tripledemic” that emerged this winter.  

Still, Amiji says that understanding exactly how the vesicles change could lead to some interesting ideas for therapies—because perhaps scientists can control those changes. He visualizes it as “hacking” the vesicle “tweets.” “How can we increase the content of these antiviral mRNAs or other molecules to have a positive effect?” he asks.

In light of the Covid-19 pandemic, the team notes that there’s already a practical real-world way to help your nose defend you in cold weather: Masking. Noses can stay snug and cozy under a mask—as any glasses-wearer whose lenses have fogged from their warm breath can attest. “Wearing masks may have a dual protective role,” says Bleier. “One is certainly preventing physical inhalation of the [viral] particles, but also by maintaining local temperatures, at least at a relatively higher level than the outside environment.”

And here’s one more idea to consider: Maybe it’s just time for a vacation somewhere warm.

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How COVID Vaccines Could Actually Help Scientists Find a Cure to Cancer

The novel coronavirus could help us cure cancer. Well, certain cancers.

The COVID pandemic gave the pharmaceutical industry the push it needed to finally finish developing messenger-RNA technology so that companies such as Moderna and Pfizer could use the tech for its COVID vaccines.

Now the pharmaceutical industry is using the same mRNA platforms for cancer vaccines. Dozens of these new vaccines are in development—and experts say there’s a chance they’ll drive the biggest decrease in cancer mortality in decades.

It’s worth noting a key difference between mRNA shots for COVID versus mRNA shots for cancer. MRNA vaccines prevent COVID. They won’t prevent cancer. Instead, they’ll treat cancer after you’ve caught it. In that sense, “vaccine”—even though it’s the accepted term—is something of a misnomer when it comes to mRNA applications for cancer. “Therapy” might be a better term.

In any event, mRNA vaccines for cancer have been in the works for a couple of years now, but the first tangible sign of real progress came just last week. On Dec. 13, Massachusetts-based Moderna and partner Merck—the New Jersey pharma giant—announced the initial results of the first ever randomized human trial for an mRNA cancer vaccine.

The two companies enrolled 157 people with late-stage melanoma for the trial. Volunteers received either the antibody therapy Keytruda, or Keytruda combined with a new vaccine called mRNA-4157. Adding mRNA-4157 reduced the risk of recurrence or death by 44 percent, the companies reported.

The key to mRNA-4157, and any other mRNA cancer vaccine, is that it can be tailored for an individual patient. As its name implies, “messenger RNA” is just a medium that communicates a message. The message is a scrap of genetic material—RNA—that tells a person’s immune system to produce a particular, disease-fighting protein.

Developers can encode mRNA to produce a wide array of proteins. For, say, preventing COVID—or reducing different cancerous tumors. “The flexibility is extraordinarily attractive,” Elias Sayour, a University of Florida neurosurgeon whose RNA Engineering Laboratory is working on cancer vaccines, told The Daily Beast.

But the flexibility that makes an mRNA vaccine so attractive is also a problem. How do you know exactly what RNA to add to a particular patient’s vaccine? “Not all cancers are the same,” Sayour explained. “To overcome this, prediction algorithms are used to identify unique information in an individual’s cancer that will be recognized by their immune system.”

MRNA was in development for nearly 50 years before COVID finally compelled governments to pump money into the effort, helping the industry finally finish the first mRNA vaccines two years ago. The basic platform for an mRNA cancer jab is actually pretty old. It’s the algorithms that are new.

“The manufacturing process starts with the identification of genetic mutations in a patient’s tumor cells that could give rise to neoantigens,” the U.S. National Cancer Institute explained. Neoantigens are proteins that form on cancer cells. “Computer algorithms then predict which neoantigens are most likely to bind to receptors on T-cells and stimulate an immune response,” the institute added.

In theory, an mRNA-maker could produce a personalized cancer vaccine in as little as four weeks, Sayour said. In practice, we need a lot more mutation-detecting algorithms and a lot more testing before mRNA vaccines are ready for routine use on cancers.

Sayour stressed that mRNA will probably work better for some cancers than for others. Not all cancers are “immunogenic,” meaning they trigger an immune response. Without an immune response, we might not know which protein to encode in an mRNA jab. “MRNA vaccines are likely to work in cancers like melanoma that are considered immunogenic,” Sayour explained. Temper your expectations for other cancers.

There are other possible limitations on mRNA as a cure for cancer. Henry Wang, a chemical engineering professor who studies vaccine production at the University of Michigan, told The Daily Beast he’s worried about production.

You can’t churn out mRNA cancer shots the same way you churn out mRNA shots for COVID. How do you scale and manage production of a drug that requires such careful and detailed individualization? “It creates an entirely different set of [quality-control] and manufacturing issues,” Wang said.

There’s also the issue of cost. Because they’re essentially boutique products, each vaccine would be designed for one or a few people and manufactured in small quantities. That means mRNA cancer jabs may end up being really expensive. It’s possible mRNA will work great against some or many cancers, but be too pricey for most people. “Someone has to address the issue of cost versus benefit,” Wang said.

Sayour, for one, said he’s optimistic. Even taking into account the problems of customization and production, mRNA seems to be our best near-term pharmaceutical tool for reducing cancer deaths. “It seems to have the best balance of commercialization and personalization.”

If pharmaceutical developers can write a host of algorithms, complete large-scale trials, figure out the production processes and thread the cost-benefit needle, cancer vaccines might be viable—and save a lot of lives.

Even if they can’t, and mRNA jabs for cancer fall flat, the basic tech could still have a bright future. Moderna is already working on mRNA jabs for around two dozen diseases, including herpes and Zika. German firm BioNTech SE is even working up mRNA for multiple sclerosis.

MRNA got its start preventing COVID. Treating cancer might be next. It’s a safe bet that neither disease will be the last to square off with this particular tech.

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Revelers throng to New Year’s parties after COVID hiatus

MELBOURNE, Australia (AP) — Revelers in major city centers across Europe and the Middle East were ushering in 2023 with countdowns and fireworks, as many cities around the globe celebrated New Year’s Eve without restrictions for the first time since the start of the coronavirus pandemic.

Children crowded a metro station in Kharkiv, Ukraine, to meet with St. Nicholas and enjoy a special performance ahead of the new year. Meanwhile, some soldiers who said they usually celebrate the holiday with family decided to stay in the trenches as they sought to defend their country.

Others in Ukraine returned to the capital, Kyiv, to spend New Year’s Eve with their loved ones. As Russian attacks continue to target power supplies, leaving millions without electricity, no big celebrations were planned. A curfew was to be in place as the clock struck midnight.

French President Emmanuel Macron delivered “a message of unity and trust” in a televised address Saturday. Referencing the war in Ukraine several times, Macron also sent a message to France’s “Ukrainian friends,” saying “we respect and admire you.”

“During the coming year, we will be unfailingly at your side. We will help you until victory and we will be together to build a just and lasting peace. Count on France and count on Europe,” he said.

Turkey’s most populous city, Istanbul, was bringing in 2023 with street festivities and fireworks. At St. Antuan Catholic Church on Istanbul’s popular pedestrian thoroughfare Istiklal Avenue, dozens of Christians prayed for the new year and marked former Pope Benedict XVI’s passing. The Vatican announced Benedict died Saturday at age 95.

The Pacific nation of Kiribati was the first country to greet the new year, with the clock ticking into 2023 one hour ahead of neighbors including New Zealand.

In Auckland, large crowds gathered below the Sky Tower, where a 10-second countdown to midnight preceded fireworks. The celebrations in New Zealand’s largest city were well-received after COVID-19 forced them to be canceled a year ago.

There was a scare in the North Island coastal city of Tauranga, about 225 kilometers (140 miles) from Auckland, when a bouncing castle was blown 100 meters (yards). Tauranga City Council reported one person was hospitalized and four people were treated on site.

Over 1 million people crowded along Sydney’s waterfront for a multi-million dollar celebration based around the themes of diversity and inclusion. More than 7,000 fireworks were launched from the top of the Sydney Harbour Bridge and a further 2,000 from the nearby Opera House.

It was the “party Sydney deserves,” the city’s producer of major events and festivals Stephen Gilby told The Sydney Morning Herald.

“We have had a couple of fairly difficult years; we’re absolutely delighted this year to be able to welcome people back to the foreshores of Sydney Harbor for Sydney’s world-famous New Year’s Eve celebrations,” he said.

In Melbourne, Australia’s second largest city, a family-friendly fireworks display along the Yarra River as dusk fell preceded a second session at midnight.

Authorities in military-ruled Myanmar announced a suspension of its normal four-hour curfew in the country’s three biggest cities so residents could celebrate New Year’s Eve. However, opponents of army rule urged people to avoid public gatherings, fearing that security forces might stage a bombing or other attack and blame it on them.

Concerns about the Ukraine war and the economic shocks it has spawned across the globe were felt in Tokyo, where Shigeki Kawamura has seen better times but said he needed a free, hot meal this New Year’s.

“I hope the war will be over in Ukraine so prices will stabilize,” he said. “Nothing good has happened for the people since we’ve had Mr. Kishida,” he said, referring to Prime Minister Fumio Kishida.

He was one of several hundred people huddled in the cold in a line circling a Tokyo park to receive free New Year’s meals of sukiyaki, or slices of beef cooked in sweet sauce, with rice.

“I hope the new year will bring work and self-reliance,” said Takaharu Ishiwata, who lives in a group home and hasn’t found lucrative work in years.

Kenji Seino, who heads the meal program for the homeless Tenohasi, which means “bridge of hands,” said the number of people coming for meals was rising, with jobs becoming harder to find after the coronavirus pandemic hit, and prices going up.

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Associated Press journalists Henry Hou in Beijing, Renata Brito in Kyiv, Yuri Kagayema in Tokyo, Grant Peck in Bangkok, Zeynep Bilginsoy in Istanbul and Thomas Adamson in Paris contributed to this report.

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China races to vaccinate elderly, but many are reluctant

BEIJING (AP) — Chinese authorities are going door to door and paying people older than 60 to get vaccinated against COVID-19. But even as cases surge, 64-year-old Li Liansheng said his friends are alarmed by stories of fevers, blood clots and other side effects.

“When people hear about such incidents, they may not be willing to take the vaccines,” said Li, who had been vaccinated before he caught COVID-19. A few days after his 10-day bout with the virus, Li is nursing a sore throat and cough. He said it was like a “normal cold” with a mild fever.

China has joined other countries in treating cases instead of trying to stamp out virus transmission by dropping or easing rules on testing, quarantines and movement as it tries to reverse an economic slump. But the shift has flooded hospitals with feverish, wheezing patients.

The National Health Commission announced a campaign Nov. 29 to raise the vaccination rate among older Chinese, which health experts say is crucial to avoiding a health care crisis. It’s also the biggest hurdle before the ruling Communist Party can lift the last of the world’s most stringent antivirus restrictions.

China kept case numbers low for two years with a “zero-COVID” strategy that isolated cities and confined millions of people to their homes. Now, as it backs off that approach, it is facing the widespread outbreaks that other countries have already gone through.

The health commission has recorded only six COVID-19 fatalities this month, bringing the country’s official toll to 5,241. That is despite multiple reports by families of relatives dying.

China only counts deaths from pneumonia or respiratory failure in its official COVID-19 toll, a health official said last week. That unusually narrow definition excludes many deaths other countries would attribute to COVID-19.

Experts have forecast 1 to 2 million deaths in China through the end of 2023.

Li, who was exercising at the leafy grounds of central Beijing’s Temple of Heaven, said he is considering getting a second booster due to the publicity campaign: “As long as we know the vaccine won’t cause big side effects, we should take it.”

Neighborhood committees that form the lowest level of government have been ordered to find everyone 65 and older and keep track of their health. They are doing what state media call the “ideological work” of lobbying residents to persuade elderly relatives to get vaccinated.

In Beijing, the Chinese capital, the Liulidun neighborhood is promising people over 60 up to 500 yuan ($70) to get a two-dose vaccination course and one booster.

The National Health Commission announced Dec. 23 the number of people being vaccinated daily had more than doubled to 3.5 million nationwide. But that still is a small fraction of the tens of millions of shots that were being administered every day in early 2021.

Older people are put off by potential side effects of Chinese-made vaccines, for which the government hasn’t announced results of testing on people in their 60s and older.

Li said a 55-year-old friend suffered fevers and blood clots after being vaccinated. He said they can’t be sure the shot was to blame, but his friend is reluctant to get another.

“It’s also said the virus keeps mutating,” Li said. “How do we know if the vaccines we take are useful?”

Some are reluctant because they have diabetes, heart problems and other health complications, despite warnings from experts that it is even more urgent for them to be vaccinated because the risks of COVID-19 are more serious than potential vaccine side effects in almost everyone.

A 76-year-old man taking his daily walk around the Temple of Heaven with the aid of a stick said he wants to be vaccinated but has diabetes and high blood pressure. The man, who would give only his surname, Fu, said he wears masks and tries to avoid crowds.

Older people also felt little urgency because low case numbers before the latest surge meant few faced risk of infection. That earlier lack of infections, however, left China with few people who have developed antibodies against the virus.

“Now, the families and relatives of the elderly people should make it clear to them that an infection can cause serious illness and even death,” said Jiang Shibo of the Fudan University medical school in Shanghai.

More than 90% of people in China have been vaccinated but only about two-thirds of those over 80, according to the National Health Commission. According to its 2020 census, China has 191 million people aged 65 and over — a group that, on its own, would be the eighth most populous country, ahead of Bangladesh.

“Coverage rates for people aged over 80 still need to be improved,” the Shanghai news outlet The Paper said. “The elderly are at high risk.”

Du Ming’s son arranged to have the 100-year-old vaccinated, according to his caretaker, Li Zhuqing, who was pushing a face-mask-clad Du through a park in a wheelchair. Li agreed with that approach because none of the family members have been infected, which means they’d be more likely to bring the disease home to Du if they were exposed.

Health officials declined requests by reporters to visit vaccination centers. Two who briefly entered centers were ordered to leave when employees found out who they were.

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AP researcher Yu Bing and video producers Olivia Zhang and Wayne Zhang contributed.

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China races to vaccinate elderly, but many are reluctant

BEIJING (AP) — Chinese authorities are going door to door and paying people older than 60 to get vaccinated against COVID-19. But even as cases surge, 64-year-old Li Liansheng said his friends are alarmed by stories of fevers, blood clots and other side effects.

“When people hear about such incidents, they may not be willing to take the vaccines,” said Li, who had been vaccinated before he caught COVID-19. A few days after his 10-day bout with the virus, Li is nursing a sore throat and cough. He said it was like a “normal cold” with a mild fever.

China has joined other countries in treating cases instead of trying to stamp out virus transmission by dropping or easing rules on testing, quarantines and movement as it tries to reverse an economic slump. But the shift has flooded hospitals with feverish, wheezing patients.

The National Health Commission announced a campaign Nov. 29 to raise the vaccination rate among older Chinese, which health experts say is crucial to avoiding a health care crisis. It’s also the biggest hurdle before the ruling Communist Party can lift the last of the world’s most stringent antivirus restrictions.

China kept case numbers low for two years with a “zero-COVID” strategy that isolated cities and confined millions of people to their homes. Now, as it backs off that approach, it is facing the widespread outbreaks that other countries have already gone through.

The health commission has recorded only six COVID-19 fatalities this month, bringing the country’s official toll to 5,241. That is despite multiple reports by families of relatives dying.

China only counts deaths from pneumonia or respiratory failure in its official COVID-19 toll, a health official said last week. That unusually narrow definition excludes many deaths other countries would attribute to COVID-19.

Experts have forecast 1 to 2 million deaths in China through the end of 2023.

Li, who was exercising at the leafy grounds of central Beijing’s Temple of Heaven, said he is considering getting a second booster due to the publicity campaign: “As long as we know the vaccine won’t cause big side effects, we should take it.”

Neighborhood committees that form the lowest level of government have been ordered to find everyone 65 and older and keep track of their health. They are doing what state media call the “ideological work” of lobbying residents to persuade elderly relatives to get vaccinated.

In Beijing, the Chinese capital, the Liulidun neighborhood is promising people over 60 up to 500 yuan ($70) to get a two-dose vaccination course and one booster.

The National Health Commission announced Dec. 23 the number of people being vaccinated daily had more than doubled to 3.5 million nationwide. But that still is a small fraction of the tens of millions of shots that were being administered every day in early 2021.

Older people are put off by potential side effects of Chinese-made vaccines, for which the government hasn’t announced results of testing on people in their 60s and older.

Li said a 55-year-old friend suffered fevers and blood clots after being vaccinated. He said they can’t be sure the shot was to blame, but his friend is reluctant to get another.

“It’s also said the virus keeps mutating,” Li said. “How do we know if the vaccines we take are useful?”

Some are reluctant because they have diabetes, heart problems and other health complications, despite warnings from experts that it is even more urgent for them to be vaccinated because the risks of COVID-19 are more serious than potential vaccine side effects in almost everyone.

A 76-year-old man taking his daily walk around the Temple of Heaven with the aid of a stick said he wants to be vaccinated but has diabetes and high blood pressure. The man, who would give only his surname, Fu, said he wears masks and tries to avoid crowds.

Older people also felt little urgency because low case numbers before the latest surge meant few faced risk of infection. That earlier lack of infections, however, left China with few people who have developed antibodies against the virus.

“Now, the families and relatives of the elderly people should make it clear to them that an infection can cause serious illness and even death,” said Jiang Shibo of the Fudan University medical school in Shanghai.

More than 90% of people in China have been vaccinated but only about two-thirds of those over 80, according to the National Health Commission. According to its 2020 census, China has 191 million people aged 65 and over — a group that, on its own, would be the eighth most populous country, ahead of Bangladesh.

“Coverage rates for people aged over 80 still need to be improved,” the Shanghai news outlet The Paper said. “The elderly are at high risk.”

Du Ming’s son arranged to have the 100-year-old vaccinated, according to his caretaker, Li Zhuqing, who was pushing a face-mask-clad Du through a park in a wheelchair. Li agreed with that approach because none of the family members have been infected, which means they’d be more likely to bring the disease home to Du if they were exposed.

Health officials declined requests by reporters to visit vaccination centers. Two who briefly entered centers were ordered to leave when employees found out who they were.

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AP researcher Yu Bing and video producers Olivia Zhang and Wayne Zhang contributed.

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Pack these snacks, says nutritionist

Travelers have a host of pathogens to dodge this winter, including the “tripledemic” of infections caused by Covid-19, flu and RSV (respiratory syncytial virus).

But there are steps people can take to reduce their chances of getting sick, say health specialists at Spain’s SHA Wellness Clinic.

The key is to develop “a resilient immune system that can defend itself from attack by viruses and bacteria,” said Dr. Vicente Mera, SHA’s head of genomic medicine.

What to eat

“The most important thing is nutrition,” Mera said.

But drastic dieting isn’t necessary, he added. Rather, travelers can simply eat whole, plant-based foods, which can help decrease inflammation, he said.

Fiber in plant-based foods also helps the gut microbiome “fight pathogens that enter or are activated through the digestive tract,” he said.

Dr. Vicente Mera, Melanie Waxman and Philippa Harvey of SHA Wellness Clinic in Alicante, Spain.

Source: SHA Wellness Clinic

Eating a nutrient-dense diet is the top recommendation from Melanie Waxman, an integrative nutrition specialist and eating coach at SHA Wellness Clinic.

That means eating “lots of vegetables, whole grains, fresh herbs, beans, sea vegetables, fruits, nuts, seeds and fermented foods,” she said.

What to pack on a plane

Waxman said travelers should snack on alkaline foods to combat acidity that is commonly caused by air travel. She recommended these easy-to-pack foods:

  • Toasted nori snacks: “Great for travelling as they are light and easy to carry in small packs. Nori is alkaline and provides a good source of vitamin C, as well as omega-3 fatty acids, protein and minerals.”
  • Instant miso soup: “Contains all the essential amino acids … and restores beneficial probiotics to the intestines … great for flights and in hotel rooms as you only need to add boiling water to the sachet.”
  • Spirulina powder: “Packed with calcium and protein. It has a high chlorophyll content … is especially beneficial after spending hours in airplane cabins. The flavor can be strong so add it to a refreshing vegetable juice … [or take] as a capsule.”  
  • Plum balls: “A wonderful travel companion, as they are extremely alkaline, full of minerals that help increase energy, aid digestion, boost immunity and improve liver functions … the balls come in a container and are easy to pack in a cabin bag.”

A fermented plum, called umeboshi in Japanese, can be added to a cup of tea on a flight. It is a “very sour plum that has been fermented for at least three years,” said SHA Wellness Clinic’s Melanie Waxman.

Tomophotography | Moment | Getty Images

Breakfast

Waxman recommends drinking one tablespoon of apple cider vinegar mixed with a glass of water before breakfast. The vinegar is “a powerful immune booster … full of probiotics,” she said.

For breakfast, a “wonderful” choice is oatmeal topped with berries, chia seeds and flax seeds, she said.

“Oats actually help the body produce melatonin more naturally,” she said. “Oats contain amino acids, potassium, B vitamins, magnesium and complex carbs … berries pack a punch of vitamin C, and the seeds provide extra omega-3 and protein.”

Jet lag

To combat jet lag, Waxman recommends taking more vitamin C.

She recommends eating sauerkraut, both before and after flying. “Fermenting cabbage causes the vitamin C and antioxidant levels to skyrocket,” she said.

Fresh vegetable juice is also great for immunity and jet lag recovery, she said.

Getting enough sleep

Sleep and immunity are closely linked, Mera said.  

“Restful sleep strengthens nature immunity,” he said, adding that poor quality, or quantity, of sleep increases the chances of falling sick.

People who average less than six hours of sleep a night, or 40 hours per week, have “a serious risk of illness,” he said.

Exercise — but don’t overdo it

Moderate exercise strengthens the immune system, Mera said.

But “30 minutes a day is more than enough,” he said. “Prolonged intense exercise can suppress the immune system.”

To avoid suppressing the immune system, travelers shouldn’t exercise to the point of exhaustion, said Dr. Vicente Mera, head of genomic medicine at SHA Wellness Clinic.

Westend61 | Westend61 | Getty Images

Examples of beneficial exercise include running, walking, swimming and cycling, he said.

Supplements, for some

Studies indicate that certain supplements — such as vitamin C, vitamin D, zinc, garlic, echinacea and green tea — may strengthen the body’s immune response, Mera said.

But, he said, they’re not necessary for everyone.

“It only compensates for nutrient deficiencies, which usually occur when nutrition is inadequate, or the immune system is very depressed,” he said.

Other recommendations

To strengthen the immune system, Waxman also suggests Epsom salt baths (“magnesium is easily absorbed through the skin”), using essential oils (“especially lavender, eucalyptus or tree tree oil”), drinking plenty of water and cutting back on alcohol, caffeine and sugar.

Mera added that relieving stress and anxiety is critical to immune health. He recommends meditation, yoga, tai chi and mindfulness to better manage emotions.

Philippa Harvey, head of SHA’s traditional Chinese medicine department, said travelers should start taking steps to strengthen their immune systems about a week before traveling.

“In TCM when someone is healthy and happy we say they have good qi, pronounced ‘chee'” she said.

She recommends eating foods that are in season, especially garlic and ginger in the autumn and winter.

She also recommends exercise and acupressure to stay healthy.

“Before we travel, a nice brisk walk in fresh air is the simplest solution,” she said.

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This Is What Scientists Expect From the COVID Virus in 2023

2023 could be the year the world finally figures out how to live with COVID. Well, most of the world. Ironically, we’ll have the Omicron variant of the SARS-CoV-2 virus to thank for it.

Successive waves of infections from Omicron and its subvariants, starting in late 2021, have produced so much natural immunity across the human population that most countries are now in a good position to weather new subvariants. “I see the United States and most of the world gradually exiting from the acute phase of the pandemic,” Lawrence Gostin, a Georgetown University global-health expert, told The Daily Beast.

Yes, people will get sick when some new form of the virus becomes dominant. But owing to their natural immunity, they probably won’t get very sick. And fresh infections will seed fresh antibodies that will then prolong the population’s natural immunity through the next wave of cases.

“The waves though will get shallower and shallower and further apart like ripples in a pond,” Jeffrey Klausner, a University of Southern California epidemiologist, told The Daily Beast.

The exception to this hard-earned natural protection is, of course, China. The only major country that enforced strict lockdowns through much of the last year and, as a result, lacks widespread natural immunity. China could spend 2023 catching up to the rest of the world, as far as COVID antibodies go.

The problem, for 1.4 billion Chinese, is that catching up means a lot of people getting infected with COVID without the strong protection that natural immunity affords. If 2023 is the first year in four years that most of the world can breathe easy despite SARS-CoV-2 being everywhere all the time, it could also be the year China gets really sick for the first time.

The world, minus China, earned its natural immunity the hard way—by catching COVID. Vaccines eased the pain, of course, but vaccine-induced antibodies don’t last forever. By the end of 2021, billions of jabs were wearing off and boosters had just become available to most people. At the same time, many countries were lifting the last major restrictions on businesses, schools and travel. That’s when Omicron showed up.

More transmissible than older variants but less severe, Omicron drove record cases in late 2021 and early 2022—and spawned subvariants such as BA.2, BA.5 and BQ.1 that drove their own, smaller surges in cases throughout the year.

But the overall trend in 2022 was toward fewer and fewer hospitalizations and deaths. In countries where people were getting back to a version of normal and the virus was circulating, all those accumulating natural antibodies were doing their thing.

It’s a virtuous, self-reinforcing cycle. “Natural immunity will be continually refreshed as the virus circulates widely, which will mean a population that over time has considerable levels of immunity,” Gostin explained.

We have been in the Omicron or sub-Omicron phase of variants now for a long time. That should continue.

That protection gives us a glimmer of hope for 2023—and beyond. “Ultimately, the cycles of repeat waves will progressively decline to a steady-level low transmission endemic state,” Edwin Michael, an epidemiologist at the Center for Global Health Infectious Disease Research at the University of South Florida, told The Daily Beast. “New variants will cause flare-ups, but I am expecting that given how robust natural immunity is, such spikes in cases will be small relative to Omicron, for example—and so easily manageable.”

Just not in China, which until a few weeks ago still enforced strict lockdowns. Widespread public protests, extreme rarities in the authoritarian state, put intense pressure on the ruling Chinese Communist Party starting in late November. On Dec. 7, the party rolled back many of the restrictions.

Epidemiologists warned that a sudden lifting of lockdowns in a country that hadn’t built up much natural immunity—and where vaccination rates are low for the most vulnerable part of the population, the elderly—could bring disaster as severe infections overwhelm hospitals.

Just a couple weeks later, they’ve already been proved right. A major outbreak in Beijing has compelled local authorities to restore some of the restrictions they’d just lifted. But a return to unpopular lockdowns only delays the inevitable.

The Chinese want to get back to their own normal. They’ll need natural antibodies to get there. But natural antibodies only come from infections. And those infections—potentially tens of millions of them—could define China’s 2023.

The rest of the world, however, might have its most normal year since 2020. Its reward for suffering through Omicron and its offspring. If there’s a possible spoiler, it’s that SARS-CoV-2 can be unpredictable.

As long as the virus is circulating, it’s mutating. For more than a year, the mutations have produced subvariants of Omicron that diminish the effectiveness of vaccines and, in the case of the latest BQ subvariants, render monoclonal antibody therapies totally ineffective. But they haven’t evaded our natural antibodies.

Klausner for one doesn’t expect that to change. “There may be many different subvariant types and no dramatic shifts. We have been in the Omicron or sub-Omicron phase of variants now for a long time. That should continue.”

If it doesn’t, and some new variant or subvariant crops up that dodges our natural antibodies, the whole world—and not just China—will have to endure waves of infections without the protection of natural immunity. That’s how the dream of a normal-ish 2023 could turn into a nightmare.

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Packed ICUs, crowded crematoriums: COVID roils Chinese towns

BAZHOU, China (AP) — Yao Ruyan paced frantically outside the fever clinic of a county hospital in China’s industrial Hebei province, 70 kilometers (43 miles) southwest of Beijing. Her mother-in-law had COVID-19 and needed urgent medical care, but all hospitals nearby were full.

“They say there’s no beds here,” she barked into her phone.

As China grapples with its first-ever national COVID-19 wave, emergency wards in small cities and towns southwest of Beijing are overwhelmed. Intensive care units are turning away ambulances, relatives of sick people are searching for open beds, and patients are slumped on benches in hospital corridors and lying on floors for a lack of beds.

Yao’s elderly mother-in-law had fallen ill a week ago with the coronavirus. They went first to a local hospital, where lung scans showed signs of pneumonia. But the hospital couldn’t handle COVID-19 cases, Yao was told. She was told to go to larger hospitals in adjacent counties.

As Yao and her husband drove from hospital to hospital, they found all the wards were full. Zhuozhou Hospital, an hour’s drive from Yao’s hometown, was the latest disappointment.

Yao charged toward the check-in counter, past wheelchairs frantically moving elderly patients . Yet again, she was told the hospital was full, and that she would have to wait.

“I’m furious,” Yao said, tearing up, as she clutched the lung scans from the local hospital. “I don’t have much hope. We’ve been out for a long time and I’m terrified because she’s having difficulty breathing.”

Over two days, AP journalists visited five hospitals and two crematoriums in towns and small cities in Baoding and Langfang prefectures, in central Hebei province. The area was the epicenter of one of China’s first outbreaks after the state loosened COVID-19 controls in November and December. For weeks, the region went quiet, as people fell ill and stayed home.

Many have now recovered. Today, markets are bustling, diners pack restaurants and cars are honking in snarling traffic, even as the virus is spreading in other parts of China. In recent days, headlines in state media said the area is “ starting to resume normal life.”

But life in central Hebei’s emergency wards and crematoriums is anything but normal. Even as the young go back to work and lines at fever clinics shrink, many of Hebei’s elderly are falling into critical condition. As they overrun ICUs and funeral homes, it could be a harbinger of what’s to come for the rest of China.

The Chinese government has reported only seven COVID-19 deaths since restrictions were loosened dramatically on Dec. 7, bringing the country’s total toll to 5,241. On Tuesday, a Chinese health official said that China only counts deaths from pneumonia or respiratory failure in its official COVID-19 death toll, a narrow definition that excludes many deaths that would be attributed to COVID-19 in other places.

Experts have forecast between a million and 2 million deaths in China next year, and the World Health Organization warned that Beijing’s way of counting would “underestimate the true death toll.”

At Baoding No. 2 Hospital, in Zhuozhou, Wednesday, patients thronged the hallway of the emergency ward. Patients were breathing with the help of respirators. One woman wailed after doctors told her that a loved one had died.

The ICU was so crowded, ambulances were turned away. A medical worker shouted at relatives wheeling in a patient from an arriving ambulance.

“There’s no oxygen or electricity in this corridor!” the worker exclaimed. “If you can’t even give him oxygen, how can you save him?”

“If you don’t want any delays, turn around and get out quickly!” she said.

The relatives left, hoisting the patient back into the ambulance. It took off, lights flashing.

In two days of driving in the region, AP journalists passed around thirty ambulances. On one highway toward Beijing, two ambulances followed each other, lights flashing, as a third passed by heading in the opposite direction. Dispatchers are overwhelmed, with Beijing city officials reporting a sixfold surge in emergency calls earlier this month.

Some ambulances are heading to funeral homes. At the Zhuozhou crematorium, furnaces are burning overtime as workers struggle to cope with a spike in deaths in the past week, according to one employee. A funeral shop worker estimated it is burning 20 to 30 bodies a day, up from three to four before COVID-19 measures were loosened.

“There’s been so many people dying,” said Zhao Yongsheng, a worker at a funeral goods shop near a local hospital. “They work day and night, but they can’t burn them all.”

At a crematorium in Gaobeidian, about 20 kilometers (12 miles) south of Zhuozhou, the body of one 82-year-old woman was brought from Beijing, a two-hour drive, because funeral homes in China’s capital were packed, according to the woman’s grandson, Liang.

“They said we’d have to wait for 10 days,” Liang said, giving only his surname because of the sensitivity of the situation.

Liang’s grandmother had been unvaccinated, Liang added, when she came down with coronavirus symptoms, and had spent her final days hooked to a respirator in a Beijing ICU.

Over two hours at the Gaobeidian crematorium on Thursday, AP journalists observed three ambulances and two vans unload bodies. A hundred or so people huddled in groups, some in traditional white Chinese mourning attire. They burned funeral paper and set off fireworks.

“There’s been a lot!” a worker said when asked about the number of COVID-19 deaths, before funeral director Ma Xiaowei stepped in and brought the journalists to meet a local government official.

As the official listened in, Ma confirmed there were more cremations, but said he didn’t know if COVID-19 was involved. He blamed the extra deaths on the arrival of winter.

“Every year during this season, there’s more,” Ma said. “The pandemic hasn’t really shown up” in the death toll, he said, as the official listened and nodded.

Even as anecdotal evidence and modeling suggests large numbers of people are getting infected and dying, some Hebei officials deny the virus has had much impact.

“There’s no so-called explosion in cases, it’s all under control,” said Wang Ping, the administrative manager of Gaobeidian Hospital, speaking by the hospital’s main gate. “There’s been a slight decline in patients.”

Wang said only a sixth of the hospital’s 600 beds were occupied, but refused to allow AP journalists to enter. Two ambulances came to the hospital during the half hour AP journalists were present, and a patient’s relative told the AP they were turned away from Gaobeidian’s emergency ward because it was full.

Thirty kilometers (19 miles) south in the town of Baigou, emergency ward doctor Sun Yana was candid, even as local officials listened in.

“There are more people with fevers, the number of patients has indeed increased,” Sun said. She hesitated, then added, “I can’t say whether I’ve become even busier or not. Our emergency department has always been busy.”

The Baigou New Area Aerospace Hospital was quiet and orderly, with empty beds and short lines as nurses sprayed disinfectant. COVID-19 patients are separated from others, staff said, to prevent cross-infection. But they added that serious cases are being directed to hospitals in bigger cities, because of limited medical equipment.

The lack of ICU capacity in Baigou, which has about 60,000 residents, reflects a nationwide problem. Experts say medical resources in China’s villages and towns, home to about 500 million of China’s 1.4 billion people, lag far behind those of big cities such as Beijing and Shanghai. Some counties lack a single ICU bed.

As a result, patients in critical condition are forced to go to bigger cities for treatment. In Bazhou, a city 40 kilometers (25 miles) east of Baigou, a hundred or more people packed the emergency ward of Langfang No. 4 People’s Hospital on Thursday night.

Guards worked to corral the crowds as people jostled for positions. With no space in the ward, patients spilled into corridors and hallways. Sick people sprawled on blankets on the floor as staff frantically wheeled gurneys and ventilators. In a hallway, half a dozen patients wheezed on metal benches as oxygen tanks pumped air into their noses.

Outside a CT scan room, a woman sitting on a bench wheezed as snot dribbled out of her nostrils into crumpled tissues. A man sprawled out on a stretcher outside the emergency ward as medical workers stuck electrodes to his chest. By a check-in counter, a woman sitting on a stool gasped for air as a young man held her hand.

“Everyone in my family has got COVID,” one man asked at the counter, as four others clamored for attention behind him. “What medicine can we get?”

In a corridor, a man paced as he shouted into his cellphone.

“The number of people has exploded!” he said. “There’s no way you can get care here, there’s far too many people.”

It wasn’t clear how many patients had COVID-19. Some had only mild symptoms, illustrating another issue, experts say: People in China rely more heavily on hospitals than in other countries, meaning it’s easier for emergency medical resources to be overloaded.

Over two hours, AP journalists witnessed half a dozen or more ambulances pull up to the hospital’s ICU and load critical patients to sprint to other hospitals, even as cars pulled up with dozens of new patients.

A beige van pulled up to the ICU and honked frantically at a waiting ambulance. “Move!” the driver shouted.

“Let’s go, let’s go!” a panicked voice cried. Five people hoisted a man bundled in blankets out of the back of the van and rushed him into the hospital. Security guards shouted in the packed ward: “Make way, make way!”

The guard asked a patient to move, but backed off when a relative snarled at him. The bundled man was laid on the floor instead, amid doctors running back and forth. “Grandpa!” a woman cried, crouching over the patient.

Medical workers rushed over a ventilator. “Can you open his mouth?” someone shouted.

As white plastic tubes were fitted onto his face, the man began to breathe more easily.

Others were not so lucky. Relatives surrounding another bed began tearing up as an elderly woman’s vitals flatlined. A man tugged a cloth over the woman’s face, and they stood, silently, before her body was wheeled away. Within minutes, another patient had taken her place.

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Orange County moves to ‘high’ level of COVID-19 transmission as cases, hospitalizations increase

SANTA ANA, Calif. (KABC) — Orange County has climbed back into the “high” level of COVID-19 transmission amid an increase in cases and hospitalizations.

Dr. Regina Chinsio-Kwong, the county’s chief health officer, says the jump to a higher level of community spread was expected because more people are socializing and gathering for the holidays.

She suggests taking a COVID test before heading to a family event or party.

“Consider testing before you go to a holiday gathering because you actually may have COVID, and if you do then you’re going to have to stay home,” Chinsio-Kwong said.

She says if you think you’ve been exposed to the virus, you should test yourself more than once before celebrating the holidays.

COVID cases are expected to rise through the first week of January.

Orange County Health Care Agency officials also encouraged residents to get up to date on vaccinations for flu and COVID-19. Officials especially encouraged vaccinated residents to get the new bivalent booster, which is designed to combat the omicron variant.

Health officials also advise the public to wash hands often and wear a mask in crowded spaces to stay safe.

Chinsio-Kwong says other illnesses are also putting a strain on resources.

“Hospitals are still being impacted by flu and RSV,” Chinsio-Kwong said. “Although we are seeing a decline in the RSV rates, the kids who are still getting into the hospital and even some of the adults who are going into the hospital are still having severe symptoms.”

City News Service contributed to this report.

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