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Adrian Griffin connecting with Giannis Antetokounmpo first step in reaching high standard – Milwaukee Journal Sentinel

  1. Adrian Griffin connecting with Giannis Antetokounmpo first step in reaching high standard Milwaukee Journal Sentinel
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Border officials discover ‘fully operational’ drug tunnel connecting Tijuana to San Diego

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U.S. authorities on Monday announced the discovery of a massive tunnel stretching under the U.S.-Mexico border that was likely used to transport drugs undetected.

The over 1,700-foot “fully operational” tunnel runs from Tijuana to an industrial warehouse in San Diego, California. Authorities said it contains a “sophisticated” structural system that was likely used to smuggle heroin, methamphetamine and fentanyl into the U.S.

The opening of a cross-border tunnel between Mexico’s Tijuana into the San Diego area is seen on Monday, May 16, 2022.
(AP Photo/Elliot Spagat)

BORDER PATROL NABS SLEW OF SEX OFFENDERS, GANG MEMBERS AS BORDER CRISIS PICKS UP

“It’s estimated to be about 1,744 feet long, 61 feet deep, with a diameter of about 4 feet at its widest point,” said Randy Grossman, U.S. Attorney for the Southern District of California. “It has reinforced walls, a rail system, and electricity for ventilation.”

U.S. authorities did not say how long the tunnel had been operating but announced $25 million worth of drugs were seized from the tunnel and its operatives over the weekend. The drugs included 1,762 pounds of cocaine, 165 pounds of meth and 3.5 pounds of heroin.

Law enforcement officers stand by the opening of a cross-border tunnel on Monday, May 16, 2022 between Mexico’s Tijuana into the San Diego area.
(AP Photo/Elliot Spagat)

Six Southern California residents were arrested and charged with conspiring to distribute cocaine, officials said.

FEDERAL JUDGE EXPECTED TO RULE ON TITLE 42 LAWSUIT WITHIN DAYS AS BORDER CRISIS ROLLS ON

The industrial warehouse where the tunnel lets out is near the U.S. Customs and Border Protection Otay Mesa Port of Entry, but U.S. authorities have not commented further on the discovery, Fox 5 reported.

This undated photo provided by Homeland Security Investigations shows the inside of a cross border tunnel between Mexico’s Tijuana into the San Diego area. (Homeland Security Investigations via AP)

The Department of Homeland Security is investigating the tunnel. 

Authorities said the tunnel was discovered as officials began sweeping the area for drugs. They conducted drug raids on several homes where drugs were known to be stashed and then checked the warehouse, where they discovered the tunnel. 

At least 15 of these sophisticated tunnels across the border have been discovered since 2006, officials said.

Authorities declined to link the latest tunnel to any specific cartel. By federal law, U.S. authorities must fill the U.S. side of tunnels with concrete after they are discovered.

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Last week, Border Patrol agents apprehended multiple sex offenders and gang members who crossed the border into the U.S. amid a border crisis that has overwhelmed border security.

The arrests included 15 illegal immigrants convicted or wanted on sex offense charges and three members of the notoriously violent MS-13 gang.

The Associated Press contributed to this report.

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Links Connecting Stress, Depression and Heart Disease Risk Found

Summary: Mouse study reveals how depression and chronic stress can have an impact on cholesterol-lowering medications and influence the risk of heart disease.

Source: American Heart Association

Results from a new mouse model may aid in understanding how depression and prolonged and severe stress increase the risk of cardiovascular disease, according to preliminary research presented at the American Heart Association’s Vascular Discovery: From Genes to Medicine Scientific Sessions 2022.

“Previous research has shown major depressive disorders and anxiety due to prolonged and severe stress have been associated with an increased rate of cardiovascular disease. The risk of developing cardiovascular disease increases in proportion to depression severity,” said lead study author Özlem Tufanli Kireccibasi, Ph.D., a postdoctoral fellow in the laboratory of Edward A. Fisher, M.D., Ph.D., M.P.H., FAHA, in the Cardiovascular Research Center at NYU Grossman School of Medicine in New York City.

“When both a major depressive disorder and cardiovascular disease are present, the prognosis is worse for both conditions.”

The researchers state theirs is the first study to use a mouse model of chronic stress and depression to investigate whether and how chronic stress may affect cholesterol-lowering medications.

Researchers examined mice lacking a low-density lipoprotein receptor (LDLr), which is required to clear LDL (bad) cholesterol from the body. These mice, like people who are born lacking the receptor, are prone to develop fatty buildups called plaque in their arteries and are subject to premature and aggressive cardiovascular disease.

Unstable plaque (prone to rupture) can break apart causing blood clots to form that block blood flow, which may lead to a heart attack or stroke. To mimic fatty plaque development in people, the mice were fed a cholesterol-rich diet for 24 weeks.

Half of the mice were exposed to social stress via sharing their living space with other larger, aggressive mice for short periods of time over ten days. After each stress episode, the mice were evaluated for social avoidance and depression-like or anxiety-like behaviors.

The mice that showed the behaviors were classified as susceptible (depressed), and the others were classified as resilient (effective coping). The other half of the mice (controls) were not exposed to social stress.

Both the susceptible (depressed) mice and the control mice were treated with an LDL-lowering medication for 3 weeks, to mimic cholesterol treatment in humans. Previous studies have found that when LDLr-deficient mice are treated with lipid-lowering medication, arterial plaque becomes less inflammatory and more stable.

After treatment, the mice were tested for changes in the number of inflammatory cells in their plaque, the number of inflammatory white blood cells (monocytes) circulating in the blood, and the number of bone marrow cells, which are precursors to the immune cells abundant in plaque.

The resilient mice were similarly evaluated, however, the analyses for this group of mice are ongoing.

The analyses found that, compared with mice not exposed to stress (the control group), the susceptible (depressed) mice from the group exposed to social stress had:

  • 50% higher rise in immune cells within plaque in their arteries;
  • double the number of circulating monocytes, which are precursors of inflammatory cells;
  • 80% increase in the number of immune-cell precursors in bone marrow;
  • less collagen within plaque in the arteries, which is an indicator of instability; and
  • a similar lowering of lipid levels when compared to the control groups’ response to LDL lowering medication.

“The major finding is that repeated stress and the physiological and behavioral effects of hostile interactions (social defeat) appear to prevent the full beneficial changes to plaques that should be induced by lipid-lowering medications,” Tufanli Kireccibasi said.

The researchers also analyzed whether differences in the bone marrow of the depressed mice may underlie the differences in the size and characteristics of the plaque.

To test this, another group of LDLr-deficient mice received bone marrow transplanted from either the susceptible (depressed) mice or the control group.

After the bone marrow transplant, the mice were fed the cholesterol-rich diet for 24 weeks.

Compared with mice that received bone marrow from the control group (no stress), the mice that received bone marrow from the susceptible group had:

  • 16% greater increase in immune-cell precursors in bone marrow;
  • 50% greater increase in inflammatory monocytes in the blood; and
  • no change in plaque size, but in plaque composition, with 23% more inflammation within the plaques.

“Taking all of our results together, we suggest that in situations in which there is chronic stress, the adverse effects of high cholesterol may be enhanced, and the benefits of low cholesterol are lessened.

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“This suggests that chronic stress mediates reprogramming at the genetic level, called epigenetic changes, in bone marrow precursors of monocytes so that when the cells enter plaques they are already more inflammatory,” Tufanli Kireccibasi said.

This mouse model may provide a way to investigate and improve treatment for depression and prolonged stress and, in turn, improve cardiovascular outcomes.

“These findings may indicate more attention to mental health is needed to fight cardiovascular disease, particularly for people with depression or chronic stress. In the next decades, new therapies for atherosclerosis should focus on altering immune responses, inhibiting inflammation and promoting pathways of plaque resolution.

“These therapies have great potential for benefiting people with cardiovascular disease, and likely particularly in those with depression,” Tufanli Kireccibasi said.

The researchers are currently collecting samples from mice that were exposed to the same repeated stress but appeared to be resilient to it.

“We will conduct the same analyses as this study to determine whether it is exposure to stress or the susceptibility to it that instigates changes in plaque leading to lessening or worsening of plaque,” Tufanli Kireccibasi said.

Co-authors are Bianca Scolaro, Ph.D.; Ada Weinstock, Ph.D.; Angelica Torres Berrio, Ph.D.; Eric Parise, Ph.D.; Flurin Cathomas, M.D.; Kenny Chan, Ph.D.; Eric J. Nestler, M.D., Ph.D.; Scott J. Russo, Ph.D.; and Edward A. Fisher, M.D., Ph.D., M.P.H., FAHA. Authors’ disclosures are listed in the abstract.

About this mental health and heart disease research news

Author: Press Office
Source: American Heart Association
Contact: Press Office – American Heart Association
Image: The image is in the public domain

Original Research: The findings will be presented at the American Heart Association’s Vascular Discovery: From Genes to Medicine Scientific Sessions 2022

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Seward, Alaska: Landslide buries primary road connecting Lowell Point community to city

Brenda Ballou, a spokesperson for the city, told CNN a few hundred people live in Lowell Point, an unincorporated, heavily-visited tourist area on the Kenai Peninsula south of Anchorage.

Marissa Beck, who owns a rental property in Seward, told CNN there are many cabins and rental houses in the area, and guests are now stuck in town or cannot get to their rentals. Many people are taking water taxis or their own boats to get to the other side of the slide.

No one was hurt when the slide occurred, Seward City Manager Janette Bower said in a Facebook post Saturday, and Ballou confirmed.

Nathaniel Caole was headed to walk his dogs on Saturday evening when he noticed a commotion on Lowell Road and pulled off to the side of the road to see what was happening. He noticed a boulder was blocking a part of the road, and cops were stopping traffic from passing by.

“Rocks would fall continuously and once in a while some bigger rubble would come down, but there were no signs that the slide was going to be that extensive.” Caole said.

“When the slide first started I noticed the first tree came down and then quickly after that I could see all the trees upwards falling in unison,” Caole said.

The slide is about 300 feet wide, CNN affiliate KTUU reported, citing Ballou.

It’s unclear what triggered the landslide, but Lowell Road frequently has falling rocks and avalanches, according to Beck.

Last month, an avalanche 60 to 80 feet deep and 300 to 400 feet wide cut off nearly 100 houses in Anchorage, about 2.5 hours north of Seward.

A local company is mobilizing to begin recovery efforts once geologists deem the area to be stable. The state is sending geologists with drone equipment to assist in assessment efforts, Ballou said.

According to Ballou, no utility functions were damaged in the landslide and communication remains open with Lowell Point.

CNN has reached out to the Seward police and fire departments for more information.

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NASA discovers rapidly growing black hole — a “missing link” connecting the origins of the universe that was hiding in plain sight

It’s a question that has plagued astronomers for years: How did supermassive black holes, which can weigh billions of times the mass of the sun, grow so large, so quickly? Now, scientists are closer than ever to the answer. 

NASA announced last week that a potential “missing link” between the universe’s first supermassive black holes and young, star-forming galaxies was hiding in plain sight — and it helps explain some of the mysteries of how the universe formed. 

Using data from the Hubble Space Telescope, astronomers found a rapidly growing black hole dubbed GNz7q. The scientists say it’s been “lurking unnoticed” in one of the most highly-studied areas of the sky, the Great Observatories Origins Deep Survey-North field. 

Using archival data from Hubble‘s Advanced Camera for Surveys, a team of international researchers determined the “monster” object existed just 750 million years after the Big Bang, during the “cosmic dawn” — the early period after the birth of our universe. It’s the first of its kind to be discovered. 

An international team of astronomers has discovered a unique object in the distant universe that is a crucial link between young star-forming galaxies and the earliest supermassive black holes. The object, which is referred to as GNz7q, is the red dot in the center of the image of the Hubble Great Observatories Origins Deep Survey-North. 

NASA, ESA, Garth Illingworth (UC Santa Cruz), Pascal Oesch (UC Santa Cruz, Yale), Rychard Bouwens (LEI), I. Labbe (LEI), Cosmic Dawn Center/Niels Bohr Institute/University of Copenhagen, Denmark


Scientists found a compact source of ultraviolet and infrared light, which could not be attributed to star formation alone; rather, it matches the radiation expected by materials falling into a black hole. They say the best explanation is a fast-growing black hole covered in dust, which will eventually emerge as a quasar, a brilliant source of light at the heart of a baby galaxy. 

This type of black hole that transforms into an extremely luminous quasar was predicted by theories and computer simulations but never observed — until now. The findings are published in the journal Nature.

“Our analysis suggests that GNz7q is the first example of a rapidly growing black hole in the dusty core of a starburst galaxy at an epoch close to the earliest supermassive black hole known in the universe,” said lead author Seiji Fujimoto. “The object’s properties across the electromagnetic spectrum are in excellent agreement with predictions from theoretical simulations.” 

This is an artist’s impression of a supermassive black hole that is inside the dust-shrouded core of a vigorously star-forming “starburst” galaxy. It will eventually become an extremely bright quasar once the dust is gone. 

NASA, ESA, N. Bartmann


“GNz7q provides a direct connection between these two rare populations and provides a new avenue toward understanding the rapid growth of supermassive black holes in the early days of the universe,” continued Fujimoto. “Our discovery provides an example of precursors to the supermassive black holes we observe at later epochs.”

Other interpretations of the data are possible, but scientists say the observations are in strong agreement with their earlier theories. They were surprised to spot the monumental discovery in what may be considered a more obvious location, suggesting the possibility of many more similar objects.   

“GNz7q is a unique discovery that was found just at the center of a famous, well-studied sky field — it shows that big discoveries can often be hidden just in front of you,” said team member Gabriel Brammer. “It’s unlikely that discovering GNz7q within the relatively small GOODS-North survey area was just ‘dumb luck,’ but rather that the prevalence of such sources may in fact be significantly higher than previously thought.”

Next, the team plans to search for related objects using dedicated surveys. Researchers will also use the newly-launched James Webb Space Telescope‘s spectroscopic instruments to further study GNz7q in more detail — and figure out just how common these types of objects are. 

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‘Gangotri wave’ connecting two of Milky Way’s spiral arms discovered

13CO integrated intensity map from the SEDIGISM survey in the velocity range −95 to −75 km s−1 showing a wave-like feature. (Bottom) 12CO integrated intensity map from the ThrUMMS survey in the same velocity range as the top panel, smoothed to an angular resolution of 5′. Images are stretched along the y-axis for a better visualization.” width=”800″ height=”337″/>
Figure 1. (Top) 13CO integrated intensity map from the SEDIGISM survey in the velocity range −95 to −75 km s−1 showing a wave-like feature. (Bottom) 12CO integrated intensity map from the ThrUMMS survey in the same velocity range as the top panel, smoothed to an angular resolution of 5′. Images are stretched along the y-axis for a better visualization.

A team of researchers from Germany, France and the U.K. has discovered a long thin filament of dense gas connecting two of the Milky Way galaxy’s spiral arms. In their paper published in The Astrophysical Journal Letters, the group describes their work studying carbon monoxide gas in the galaxy.

Prior research has shown that other galaxies have features called feathers—long gas filaments with barbs that look from Earth like feathers. But because it is very difficult to study the Milky Way galaxy from an Earth perspective, no such features have been seen, until now.

In their work, the researchers were studying concentrations of carbon monoxide gas in data from the APEX telescope in San Pedro de Atacama, Chile. They noticed concentrations that had not been seen before, and after taking a closer look, discovered that it was part of a large gas formation that extended from near the center of the galaxy outward, connecting two of the arms that give the galaxy its distinctive look.

The researchers named the formation the Gangotri wave—an homage to the massive glacier whose melting gives rise to the Ganges River. In India, the Milky Way galaxy is known as Akasha Ganga. The newly discovered feather spans approximately 5.6764e+16 to 1.22989e+17 kilometers in reaching between the two arms and is approximately 1.6083242e+17 kilometers from the rotational center of the galaxy. They have also estimated its mass to be approximately equal to nine suns. Prior to the new discovery, all of the gas tendrils found in the Milky Way have aligned with the spiral arms.

The researchers found that the Gangotri wave has another unique and interesting feature in that it is not as straight as expected. Instead, it zig-zags back and forth along its length in a pattern similar to a sine wave. The researchers were not able to explain the strange phenomenon but note that some force must be at play—a force that is likely to be the focus of many upcoming research efforts. The team plans to continue their study of gases in the Milky Way, this time actively looking for new feathers.


Video: Rotating galaxy disks in the early universe


More information:
V. S. Veena et al, A Kiloparsec-scale Molecular Wave in the Inner Galaxy: Feather of the Milky Way?, The Astrophysical Journal Letters (2021). DOI: 10.3847/2041-8213/ac341f

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‘Gangotri wave’ connecting two of Milky Way’s spiral arms discovered (2021, November 27)
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