Tag Archives: changer

This FSR 3 mod is a game changer for older Nvidia graphics cards – PCGamesN

  1. This FSR 3 mod is a game changer for older Nvidia graphics cards PCGamesN
  2. Old Nvidia gaming GPUs enjoy huge performance uplifts from new mod — DLSS 3 to FSR 3 mod enables frame generation to deliver up to 75% better performance on previous GeForce RTX GPUs Tom’s Hardware
  3. 2 ways you can boost game performance by 75% on old PCs Digital Trends
  4. Tested: the DLSS 3/FSR 3 mod that brings frame generation to older Nvidia cards Eurogamer.net
  5. AMD to the rescue for Nvidia RTX 2000 and 3000 GPUs, as fudge for DLSS 3 games turbocharges frame rates to an eye-opening level TechRadar

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Mayor Adams, Governor Hochul call President Biden’s protection of Venezuelans a game changer in migrant crisis for New York City – WABC-TV

  1. Mayor Adams, Governor Hochul call President Biden’s protection of Venezuelans a game changer in migrant crisis for New York City WABC-TV
  2. Mayorkas Announces Extension and Redesignation of Venezuela for Temporary Protected Status – HS Today HSToday
  3. Adams and Hochul call Biden’s protection of Venezuelans a game changer Eyewitness News ABC7NY
  4. U.S. Will Allow Nearly 500000 Venezuelan Migrants to Work Legally The New York Times
  5. Adams reacts to Biden admin legalizing thousands of migrants after saying crisis will ‘destroy’ NYC Fox News
  6. View Full Coverage on Google News

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Ukraine says cluster munitions will be ‘game changer’ against Russia – POLITICO Europe

  1. Ukraine says cluster munitions will be ‘game changer’ against Russia POLITICO Europe
  2. Bulgarian secret services contradict on Russian war’s external impact EURACTIV
  3. Zelenskiy Visits Sofia, Prague To Drive Home Messages On NATO Membership, Demand For More Arms Radio Free Europe / Radio Liberty
  4. Zelenskiy Expected To Visit Sofia On Same Day As Parliamentary Vote On Ukraine’s Membership In NATO Radio Free Europe / Radio Liberty
  5. Four Pakistani Soldiers Killed Amid Surge In Terror Attacks Radio Free Europe / Radio Liberty
  6. View Full Coverage on Google News

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Fentanyl vaccine poised to be ‘game changer’ in fight against addiction

The end to the fentanyl crisis may be in sight, thanks to a team of researchers in Texas who claim they have successfully developed a vaccine that could be a “game changer” in addiction treatment.

A team led by the University of Houston has developed what they say is a fentanyl vaccine that can block the synthetic opioid from entering the brain — essentially curing addiction by eliminating the euphoric high.

“There’s no question about it. We developed something that’s a new game changer,” Dr. Colin Haile, a research associate professor of psychology at UH and the Texas Institute for Measurement, Evaluation, and Statistics (TIMES) told Fox News during a recent tour of the research facility.

KIDS UNDER 14 ARE DYING OF FENTANYL POISONING FASTER THAN ANY OTHER AGE GROUP: ANALYSIS

“It’s a completely different strategy of treating an individual with opioid use disorder.”

Their vaccine works in an entirely different way, said Dr. Haile, from other treatments for opioid use disorder and overdose deaths. 

Dr. Colin Haile (center, wearing glasses) is seen here cleaning a sample at his lab at the University of Houston. He believes that the fentanyl vaccine his team has developed can help those in addiction recovery.
(Fox News Media)

It essentially produces antibodies much like other vaccines make those antibodies against a virus or bacteria. 

Dr. Haile’s vaccine does the same by blocking fentanyl from entering the user’s brain. 

Proteins are used to keep the drug in the bloodstream — then it is flushed out through the kidneys.

NARCAN VENDING MACHINES ARE THE LATEST WEAPON AGAINST OPIOID OVERDOSES

“It’s similar to the hepatitis B vaccine. The vaccine stimulates the body to make antibodies against fentanyl,” Dr. Haile said, “and if an individual consumes fentanyl, those antibodies will bind to the drug and prevent it from getting into the brain.”

He added, “Without the vaccine, fentanyl penetrates the brain quite readily, stimulates euphoric centers, and also can stimulate parts of the brain that control respiration, leading to overdose and death.” 

A lethal dose of fentanyl is pictured next to a penny.
(Drug Enforcement Administration)

Testing on lab rats and mice showed very promising results, said Haile, and he believes they will see the same findings once human trials begin in the coming weeks.

“We have done extensive studies in mice and rats and the effect of the vaccine was quite dramatic,” he says. We demonstrated that, yes, the vaccine prevents fentanyl from penetrating the brain. It keeps it in the blood. And then the fentanyl is removed from the body.”

DOCTORS WARN FENTANYL BECOMING STRONGER, MAKING REVERSING OVERDOSES MORE CHALLENGING

He believes the vaccine could be available to the public within two years, he said.

“Given that the vaccine is already made up of components that are already on the market and already have been tested in humans, we feel that when it comes time to submit our application to the FDA, we are hopeful that the approval process will be expedited.”

The team began working on the fentanyl vaccine nearly six years ago. 

Dr. Haile and his team began working on the vaccine nearly six years ago when an unprecedented rise in overdose death started to surface. The vaccine was developed from two protein strands already used in other vaccine treatments.

Fentanyl and other synthetic opioids have become the primary cause of overdose deaths in the U.S. and it’s estimated that over 110,000 occurred between August 2021 and August 2022 – a stunning record for a single 12-month period.

Haile and his team say human trials will begin soon. They hope for FDA approval within the next two years.
(Fox News Media)

With over 150 people dying every day from overdoses of synthetic opioids, according to the CDC, the vaccine comes at a crucial time as the drug crisis grips the country.

“Unfortunately, starting about 10 years ago or so, the manufacture of fentanyl was increased, and it became much more part of the mainstream in terms of illicit drug markets, to see it first being part of the drug supply and more recently, just completely taking over for any other illicit opioid,” Dr. Wilson Compton, deputy director with the National Institute on Drug Abuse, which consults with Dr. Haile’s research team, said to Fox News. 

“So, heroin [use] is dropping in many parts of the country because fentanyl is cheaper, easier to smuggle, and produces the same brain effects.”

ERIC ADAMS WARNS FENTANYL WILL ‘DESTROY GENERATIONS’ IF NEW YORK CONTINUES ‘SLEEPING ON’ CRISIS

The vaccine development has been funded by the Department of Defense, where officials tell Fox News that backed the project after the need to address the prevalence of addiction among the families of many service members.

“We need this vaccine … There’s so many people that can be helped.”

Dr. Haile points out that this vaccine would be best for those who have already undergone detox, as it will prevent relapses.

“This vaccine is for individuals that want to quit. It is not for individuals that do not want to quit,” he says. 

“A vaccinated individual — if they do not want to quit their opioid addiction, they can take other drugs, other opioid drugs, or just other drugs that are vaccine antibodies do not target.”

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People have already been contacting the team at the University of Houston asking to be added to the upcoming trials — something that Dr. Haile says underscores the need for this treatment.

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“We need this. We need this vaccine. And there’s so many people that can be helped,” he says.

“It needs to happen, and it will happen.”

Fox News’ Evan Goldman contributed to this report.

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James Webb telescope: New data on WASP-39b is a ‘game changer,’ scientists say

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The James Webb Space Telescope has captured a detailed molecular and chemical portrait of a faraway planet’s skies, scoring another first for the exoplanet science community.

WASP-39b, otherwise known as Bocaprins, can be found orbiting a star some 700 light-years away. It is an exoplanet — a planet outside our solar system — as massive as Saturn but much closer to its host star, making for an estimated temperature of 1,600 degrees Fahrenheit (871 degrees Celsius) emitting from its gases, according to NASA. This “hot Saturn” was one of the first exoplanets that the Webb telescope examined when it first began its regular science operations.

The new readings provide a full breakdown of Bocaprins’ atmosphere, including atoms, molecules, cloud formations (which appear to be broken up, rather than a single, uniform blanket as scientists previously expected) and even signs of photochemistry caused by its host star.

“We observed the exoplanet with multiple instruments that, together, provide a broad swath of the infrared spectrum and a panoply of chemical fingerprints inaccessible until (this mission),” said Natalie Batalha, an astronomer at the University of California, Santa Cruz, who contributed to and helped coordinate the new research, in a NASA release. “Data like these are a game changer.”

The new data provided the first sign in an exoplanet’s atmosphere of sulfur dioxide, a molecule produced from chemical reactions triggered by the planet’s host star and its high-energy light. On Earth, the atmosphere’s protective ozone layer is created in a similar way from heat and sunlight in a photochemical reaction.

Bocaprins’ close proximity to its host star makes it an ideal subject for studying such star-planet connections. The planet is eight times closer to its host star than Mercury is to our sun.

“This is the first time we have seen concrete evidence of photochemistry — chemical reactions initiated by energetic stellar light — on exoplanets,” said Shang-Min Tsai, a researcher at the University of Oxford in the United Kingdom, in a NASA release. “I see this as a really promising outlook for advancing our understanding of exoplanet atmospheres.”

Other compounds detected in Bocaprins’ atmosphere include sodium, potassium and water vapor, confirming previous observations made by other space and ground-based telescopes, including the Hubble Space Telescope.

Having such a complete roster of chemical ingredients in an exoplanet atmosphere provides insight into how this planet — and perhaps others — formed. Bocaprins’ diverse chemical inventory suggests that multiple smaller bodies, called planetesimals, had merged to create an eventual goliath of a planet, of similar size to the second-largest planet in our solar system.

“This is just the first out of many exoplanets that are going to be studied in detail by JWST. … We are already getting very exciting results,” Nestor Espinoza, an astronomer at the Space Telescope Science Institute, told CNN. “This is just the beginning.”

The findings are favorable for suggesting the capability of Webb’s instruments to conduct investigations on exoplanets. By revealing a detailed descriptor of an exoplanet’s atmosphere, the telescope has performed beyond scientists’ expectations and promises a new phase of exploration on the broad variety of exoplanets in the galaxy, according to NASA.

“We are going to be able to see the big picture of exoplanet atmospheres,” said Laura Flagg, a researcher at Cornell University and a member of the international team that analyzed data from Webb, in a statement. “It is incredibly exciting to know that everything is going to be rewritten. That is one of the best parts of being a scientist.”

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Fentanyl Vaccine Breakthrough – Potential “Game Changer” for Opioid Epidemic

Researchers report the breakthrough discovery of a new vaccine that targets the dangerous synthetic opioid fentanyl. It can block fentanyl’s ability to enter the brain, thus eliminating the drug’s “high.”

Study suggests new vaccine could prevent deadly opioid from entering the brain.

A new vaccine has been developed that targets the dangerous synthetic opioid fentanyl that could block its ability to enter the brain, thus eliminating the drug’s “high.” The breakthrough discovery could have major implications for the nation’s opioid epidemic by becoming a relapse prevention agent for people trying to quit using opioids. While research reveals Opioid Use Disorder (OUD) is treatable, an estimated 80% of those dependent on the drug suffer a relapse. The vaccine was developed by a research team led by the University of Houston.

Published recently in the journal Pharmaceutics, the findings could not be timelier or more in demand: Over 150 people die every day from overdoses of synthetic opioids including fentanyl, which is 50 times stronger than heroin and 100 times stronger than morphine. Consumption of about 2 milligrams of fentanyl (the size of two grains of rice) is likely to be fatal depending on a person’s size.

Colin Haile, University of Houston research associate professor of psychology and the Texas Institute for Measurement, Evaluation and Statistics (TIMES), and a founding member of the UH Drug Discovery Institute. Haile is reporting a breakthrough fentanyl vaccine that could be a “game changer” in opioid addiction. Credit: University of Houston

“We believe these findings could have a significant impact on a very serious problem plaguing society for years – opioid misuse. Our vaccine is able to generate anti-fentanyl antibodies that bind to the consumed fentanyl and prevent it from entering the brain, allowing it to be eliminated out of the body via the kidneys. Thus, the individual will not feel the euphoric effects and can ‘get back on the wagon’ to sobriety,” said the study’s lead author Colin Haile, a research associate professor of psychology at UH and the Texas Institute for Measurement, Evaluation and Statistics (TIMES), and a founding member of the UH Drug Discovery Institute.

In another positive finding, the vaccine did not cause any adverse side effects in the immunized rats involved in lab studies. The team plans to start manufacturing clinical-grade vaccine in the coming months with clinical trials in humans planned soon.

Fentanyl is an especially dangerous threat because it is often added to street drugs like cocaine, methamphetamine and other opioids, such as oxycodone and hydrocodone/acetaminophen pills, and even to counterfeit benzodiazepines like Xanax. These counterfeit drugs laced with fentanyl add to the amount of fentanyl overdoses in individuals who do not ordinarily consume opioids.

In the lab: Therese Kosten, professor of psychology and director of the Developmental, Cognitive & Behavioral Neuroscience program and Colin Haile, research associate professor of psychology and the Texas Institute for Measurement, Evaluation and Statistics (TIMES), and a founding member of the UH Drug Discovery Institute. Credit: University of Houston

“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile.

The vaccine tested contains an adjuvant derived from E. coli named dmLT. An adjuvant molecule boosts the immune system’s response to vaccines, a critical component for the effectiveness of anti-addiction vaccines. The adjuvant was developed by collaborators at the Tulane University School of Medicine and has proven vital to the efficacy of the vaccine. Also on the team are Greg Cuny, Joseph P. & Shirley Shipman Buckley Endowed Professor of Drug Discovery at the UH College of Pharmacy along with researchers from Baylor College of Medicine and Michael E. DeBakey Veteran’s Affairs Medical Center.

Current treatments for OUD are methadone, buprenorphine and naltrexone, and their effectiveness depends upon formulation, compliance, access to medications and the specific misused opioid.

Therese Kosten, professor of psychology and director of the Developmental, Cognitive & Behavioral Neuroscience program at UH, calls the new vaccine a potential “game changer.”

“Fentanyl use and overdose is a particular treatment challenge that is not adequately addressed with current medications because of its pharmacodynamics and managing acute overdose with the short-acting naloxone is not appropriately effective as multiple doses of naloxone are often needed to reverse fentanyl’s fatal effects,” said Kosten, senior author of the study.

Reference: “An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats” by Colin N. Haile, Miah D. Baker, Sergio A. Sanchez, Carlos A. Lopez Arteaga, Anantha L. Duddupudi, Gregory D. Cuny, Elizabeth B. Norton, Thomas R. Kosten and Therese A. Kosten, 26 October 2022, Pharmaceutics.
DOI: 10.3390/pharmaceutics14112290

The study was funded by the Department of Defense through the Alcohol and Substance Abuse Disorders Program managed by RTI International’s Pharmacotherapies for Alcohol and Substance Use Disorders Alliance, which has funded Haile’s lab for several years to develop the anti-fentanyl vaccine.



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DAOs: A game changer in need of new rules

September 30, 2022 – The decentralized autonomous organization (DAO) is a relatively novel structure gaining popularity in the blockchain community. DAOs are community-led entities with no central leadership built on a blockchain using smart contracts, and with no restriction on the geographic location of its members, potentially resulting in an international organization.

DAOs are seen as transparent and their lack of central leadership is attractive to many. What DAO members often do not realize, however, is that they may be unknowingly exposing themselves to personal liability, simply by virtue of their membership in a DAO.

Unlike shareholders or members of more traditional legal entities, DAO members do not enjoy protections against personal liability for the DAO’s actions unless there is a state law that offers such protection.

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In this article, the authors examine recent case examples that illustrate the risks of DAO membership and the urgent need for federal and state rulemaking that is public and transparent, in contrast to regulation by enforcement.

bZerox DAO | Ooki DAO

Earlier this month, the Commodity Futures Trading Commission (CFTC) issued a settlement order imposing a $250,000 civil penalty on the bZerox (bZx) DAO, which unlawfully offered to its members leveraged and margined retail commodity transactions in digital assets in violation of the Commodity Exchange Act (CEA) and CFTC regulations. These margined retail commodity transactions were required to take place on a designated contract market, but did not.

CFTC also commenced a federal civil enforcement action in California based on the violations of the same laws against Ooki DAO (Ooki), a successor in interest of bZx, which has the same members and operates the same software protocol.

Importantly, CFTC’s settlement order also held personally liable Tom Bean and Kyle Kistner, co-founders of bZx who transferred control of bZx’s software protocol to Ooki. While the DAO’s conduct was found to be illegal, the finding of personal liability of the owners based solely on their status as voting token holders of the Ooki DAO should cause concern among DAO members.

CFTC’s approach to deciding who is responsible for the violations was the subject of internal debate within the CFTC. CFTC’s Commissioner, Summer K. Mersinger, issued a dissenting statement, calling the decision to impose liability on bZx’s co-founders “arbitrary” and “based on an unsupported legal theory amounting to regulation by enforcement while federal and state policy is developing.”

As she noted, there are three bases on which the CFTC can rely to support charging a person with violations of the CEA and CFTC rules committed by another person or entity: (1) principal-agent liability, (2) aiding-and-abetting liability, and (3) control person liability.

Yet, CFTC based their decision on California precedents from contract and tort law that hold that individual members of a for-profit unincorporated association are personally liable for the debts of the association. Commissioner Mersinger stressed that the CFTC seemingly acted outside the scope of its authority in acting in a manner not intended by Congress.

She noted that the CFTC engaged in regulation by enforcement that will have far-reaching policy implications. Specifically, the Commission’s settlement order and complaint arbitrarily define the Ooki DAO unincorporated association as comprising those who vote on proposals with their Ooki tokens.

This definition creates an unequitable division between token holders based on the happenstance of voting or not voting with their token. Under the CFTC definition, a token holder that voted on any issue becomes a member subject to personal liability and a token holder who failed to vote for any reason is not considered a member and is exempt from liability. This definition discourages voting participation in the DAO governance.

Commissioner Mersinger explained that the CFTC had better paths available in initiating a public notice-and-comment rulemaking on the issues of how DAO members should be defined and who CFTC may hold personally liable for a DAO’s violations. This process would have allowed public input from interested parties and would highlight possible consequences of the Commission’s approach to DAOs.

Furthermore, Commissioner Mersinger expressed an opinion that the CFTC could have achieved the same result by using the aiding-and-abetting standard when finding Bean and Kistner personally liable rather than relying on novel legal theories that are likely to have far-reaching implications on DAOs.

Sarcuni v. bZx

bZx’s civil troubles began earlier this year when, in Sarcuni v. bZerox et al., members of bZx filed a class action against the DAO, its founders and investors following a successful “phishing” attack that resulted in a theft of $55 million in funds from the platform. The plaintiffs alleged the theft was possible due to the lack of security features on the platform.

Defendant-founders filed motions to dismiss, claiming that it is improper to hold them liable as the stolen funds belonged to the DAO. The motions argued that since bZx was owned and managed by the DAO itself, only the DAO can be liable. While the plaintiffs were members of the DAO, they claimed that they were not “meaningful” members and lacked sufficient control for any liability to be imposed.

The court’s decision in Sarcuni is expected to establish the standards for founder and manager liability for the actions or omissions of a DAO. Unlike many other DAOs, the bZx DAO is a limited liability company under the laws of Delaware.

In addition, there is a holding company, bZx Holding Corp., incorporated in the State of Wyoming. The court will need to take into consideration the LLC status and whether Delaware’s laws afford the founders protection.

Regulation of DAOs

bZx’s misadventures and their ramifications highlight the fact that the status of DAO members is uncertain, regulation and enforcement are not uniform, and there is dire need for clarity as to the status and risk of personal liability for DAO members.

Most DAOs lack the legal safeguards afforded to limited liability companies. Members could find themselves facing personal liability merely because they used their token for a simple vote, possibly unrelated to any DAO actions that may later result in liability.

A few states, such as Vermont, Wyoming and Tennessee, have enacted legislation providing some protections to DAOs and their members. While these laws have not yet been tested by the judicial branch, and while they have been criticized as being out of touch with the realities of DAOs, at least it’s a start.

Wyoming enacted legislation in 2022 to protect DAO members from personal liability by allowing DAOs to obtain legal status as limited liability companies. The statute defines DAO voting and quorum requirements and allows DAOs to define their own quorum (prior statutory requirement of 50% of the membership quorum was difficult to achieve with DAOs having fluid membership and possibly thousands of owners). No member has a fiduciary duty under the statute.

Vermont also passed its own blockchain-based statute. The Vermont legislation does not specifically address DAOs but authorizes creation of a new type of business entity — the Blockchain-Based LLC (BBLLC). A BBLLC is allowed to customize its governance structure. The operating agreement must define the rights and obligations of each participant group within the BBLLC.

Tennessee is another state that has afforded DAOs protection within its laws. Under Tennessee’s bill, unless stated otherwise in the articles or operating agreement, the management of the DAO can be member-managed, or contract managed.

There is no requirement that the DAO have a centralized governance or managers. Furthermore, the law does not even require that the person forming the DAO be a member. The DAO specifically states that members do not owe a fiduciary duty to the DAO.

The biggest criticism of existing DAO legislation is that they place additional burdens on DAOs without conferring real benefits in exchange. This stems from a lack of understanding of how DAOs function. The CFTC order also highlights the need to define exactly who is a member or control person in a DAO.

Analysis and conclusion

bZx DAO was established in 2019 before two of these laws were in effect. They incorporated in Delaware, traditionally the most corporate-friendly state. CFTC’s Complaint alleges that bZx’s rebrand to Ooki was undertaken solely to escape regulatory enforcement, but the new organizational form exposed the members of the unincorporated association to personal liability.

Most DAOs are unincorporated associations and many have not registered in Wyoming, Tennessee or Vermont, and thus their members are similarly at risk of personal liability for the actions of the DAO.

DAOs usually comprise thousands of members. Each member has the opportunity to vote on the governance of the DAO. While the CFTC has acknowledged that DAOs can be used for good governance, the CFTC order is a warning to DAOs and their members that good actors can be punished without fault for the actions of bad actors within the DAO.

DAOs have the potential to change how entities govern themselves — how companies operate — and allow members to have a voice is decisions that impact their companies. Companies will employ blockchain technology to enhance themselves and their relationships with their customers.

The CFTC is the federal agency responsible for the oversight of digital assets including cryptocurrencies such as Ethereum, Solana, Polygon and many more. Most DAOs use these tokens for members to gain access to the community and participate in its governance. Members of DAOs not incorporated in the appropriate jurisdiction, or without a governance structure protecting members, are leaving themselves open to personal liability.

Considering the CFTC decision, DAOs will do well to revisit their governance structure and consider how best to insulate members from unintended personal liability. Furthermore, DAO members should review their insurance coverage as they may find they lack coverage under their personal and business policies for DAO liability exposure.

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Opinions expressed are those of the author. They do not reflect the views of Reuters News, which, under the Trust Principles, is committed to integrity, independence, and freedom from bias. Westlaw Today is owned by Thomson Reuters and operates independently of Reuters News.

Jana S. Farmer

Jana S. Farmer, a partner at Wilson ElserMoskowitz Edelman & Dicker LLP’s White Plains, New York office, chairs the firm’s art law practice and is a member of the firm’s intellectual property and technology practice. She advises clients on emerging legal issues in the technology space, including those involving non-fungible tokens and blockchain technology. She can be reached at jana.farmer@wilsonelser.com.

John Cahill

John Cahill is an associate at Wilson ElserMoskowitz Edelman & Dicker LLP with a focus on general casualty and liability. Based in White Plains, New York, he assists clients with risk and crisis management at the prelitigation phase of potential claims and specializes in the burgeoning field of cryptocurrencies. He can be reached at john.cahill@wilsonelser.com.

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HIMARS ‘Game Changer’ in Ukraine War, Russia ‘in Dire Shape’: Ex-General

Retired U.S. Army General Mark Hertling said Saturday that High Mobility Artillery Rocket Systems (HIMARS) given to Ukraine to assist in its fight against Russia are a “game changer,” contending that Moscow’s forces are now “in dire shape.”

The White House on Friday announced that an additional $270 million in security assistance would be sent to Ukraine, including four additional HIMARS. The rocket systems have been seen as crucial to helping Kyiv’s forces repel Moscow’s military.

That announcement from the Biden administration came after a senior U.S. defense official told journalists Friday that Ukraine had utilized HIMARS to take out more than 100 “high value” targets. Those strikes effectively destroyed ammunition depots, long-range artillery positions, command posts, air-defense sites, and radar and communications nodes, the official said.

“As for HIMARS – w/ fewer rounds, greater range, precision accuracy – it’s a game changer,” Hertling tweeted in a lengthy thread Saturday, providing analysis on the war. The retired general previously served as the commander of the U.S. Army Europe and the Seventh Army.

“Russia is in dire shape & losing, Ukraine is adapting to the fight & winning,” he asserted.

Earlier on Saturday, Ukrainian President Volodymyr Zelensky shared his appreciation for the new HIMARS being sent by the U.S.

“Thank you @POTUS [Biden] for the new defense aid package for Ukraine. Critically important, powerful arms will save our soldiers’ lives, speed up the liberation of our land from the Russian aggressor. I appreciate the strategic friendship between our nations. Together to victory!” Zelensky wrote on Twitter several hours after the White House made the announcement.

Lithuania’s Minister of Foreign Affairs Gabrielius Landsbergis touted the delivery of HIMARS to Ukraine as successfully pressuring Russia, leading to a diplomatic breakthrough regarding the port in Odessa, Ukraine.

“The agreement to unblock Odesa would have been impossible without HIMARS. It’s now very clear that the war will end earlier if we arm Ukraine faster,” Landsbergis tweeted Friday.

The U.S. has provided Ukraine with billions of dollars in military and humanitarian assistance as it defends itself against Moscow’s aggression. Russian President Vladimir Putin launched the internationally condemned war five months ago on February 24, bizarrely claiming that Kyiv’s government is led by Nazis. In reality, Zelensky is Jewish and had family members killed in the Holocaust genocide perpetuated by the German Nazis in World War II.

Retired U.S. Army General Mark Hertling called the HIMARS used by Ukraine against Russia a “game changer” in a Saturday tweet. Above, HIMARS launchers fire salvoes during the “African Lion” military exercise in the Grier Labouihi region in southeastern Morocco on June 9, 2021.
FADEL SENNA/AFP via Getty Images

On Wednesday, General Mark Milley, chairman of the Joint Chiefs of Staff, told reporters that Ukraine’s use of HIMARS was “degrading” Russia’s capabilities.

“These strikes are steadily degrading the Russian ability to supply their troops, command and control of their forces, and carry out their illegal war of aggression,” he said.

Russia claimed on Friday that it had destroyed four HIMARS this month that were utilized by Ukraine. However, U.S. and Ukrainian officials have disputed those reports.

Newsweek reached out to the Russian foreign ministry for comment.



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A Passive Automatic CNC Tool Changer

[Marius Hornberger] has been busy hacking his “Hammer” CNC router again, and now it sports a much desired feature — an automatic tool-changer. Having wanted one for a while, [Marius] was unhappy sacrificing a big chunk of useable bed area just to park the tool-changer magazine. An obvious solution would be to have the magazine retract away from the bed, outside of the working area. Sadly, the CNC controller had only enough spare outputs to drive the pneumatic tool changer (mounted on the spindle) leaving none spare to control the magazine assembly. So, there was only one obvious route to take, use some simple spring-loaded mechanics to move the magazine into tool-picking range with the Y axis motion instead.

Obviously, the whole thing is CNC machined on the machine itself, taking only a couple of iterations and smidge of table-saw action to get everything to fit well and operate smoothly without binding or colliding with the moving gantry. A cunning pair of levers on each end of the magazine allow it to move much further than the advancing gantry, swinging it quickly into position when the Y axis is at the extreme of its travel, and retracting away when the gantry moves back. Another nice addition to the build was a tool depth sensor (AKA: a switch) mounted off to one side, which allows the machine to find the bottom of each tool, if it is not known, so the Z axis can compensate. When combined with the automatically retracting dust shoe, this is a definitely a CNC build we’d love to see in a shop near us!

We’ve had a fair few CNC hacks over the years, including tool changers, like this one, but 3D printers can use some tool changer love too!

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Africans Welcome New Malaria Vaccine. But Is It a ‘Game Changer’?

“The vaccine saves lives but it will not be a silver bullet,” said Dr. Githinji Gitahi, the chief executive officer for Amref Health Africa, a nongovernmental organization.

The vaccine, called Mosquirix, targets the deadliest malaria parasite and the most common in Africa — Plasmodium falciparum. While the vaccines are a “huge addition to the fight” against malaria, said Dr. Gitahi, health officials will still have to deploy “a Swiss cheese strategy,” which includes insecticide-treated bed nets and indoor spraying.

Faith Walucho is the mother of an 11-month-old who was recently diagnosed with malaria. The 29-year-old trader of used clothing in the city of Kisumu in western Kenya said she received the news about the vaccines “with a lot of happiness.” In Kenya, an estimated 10,700 deaths from malaria are recorded annually, and Kisumu, on the shores of Lake Victoria, is one of the high-malaria regions where the vaccine was tested.

As soon as she’s able to get a dose for her daughter, Ms. Walucho said, “I will run” to get it.

In Malawi’s capital, Lilongwe, Jenala Mwafulirwa, a 52-year-old mother of five, welcomed the news of the vaccine, saying that too many children in her family had been lost to the disease, particularly in rural areas where access to health care is limited.

“This vaccine has come at the right time,” she said.

But in some places, people voiced skepticism about the vaccine, in part because of mistrust of the World Health Organization.

“I wonder why they want to help Africa,” said Mamadou Tounkara, a 40-year-old-teacher in Senegal’s capital, Dakar. He asked why the W.H.O. did not instead fund better hygiene and sanitation systems. “If W.H.O. wants to help eradicate this disease, they can do it without the vaccine.”

Yet public health officials say the vaccine, which has been in development for more than 30 years, has already proved to be an important weapon in the war against the disease.

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