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Gen Z wants to ‘wait a little bit’ to get COVID vaccine. Experts say there’s no time to waste.

Johnson Shao, a nursing student at the College of Southern Nevada, administers the Moderna COVID-19 vaccine at a vaccination center at UNLV in Las Vegas on April 26.

Patricia Smithson, 23, thought about her aunt in New York who died alone of COVID-19 when she decided to get her vaccine.

Benny Romero, 24, hasn’t found the time to get his yet and might wait a little longer.

Gracie Poynter, 21, knows her concerns about the safety of the shots could jeopardize her job in health care.

They’re all part of a group once considered a low priority in the nation’s vaccine rollout: Generation Z, loosely defined as those in their mid-20s and younger. But now that vaccinations are readily available to Americans 12 and up, the nation’s lagging vaccine rate among young adults is raising alarms.

It’s an increasingly urgent concern as the especially-contagious delta variant circulates in the U.S. and schools and colleges ready for a return to in-person classes this fall.

“Now is the window of opportunity,” Judy Klein – president of Unity Consortium, a non-profit that advocates for vaccine protection for adolescents and young adults – told USA TODAY. If high rates of unvaccinated students show up at schools, that’s a recipe for COVID outbreaks and yet another semester derailed by the virus, she fears.

Tracking COVID-19 vaccine distribution by state: How many people have been vaccinated in the US?

A June U.S. Centers for Disease Control and Prevention report found that only about half of adults 24 and under were “vaccinated or definitely planning to get vaccinated.” That report called out the group’s low vaccine rates as compared with other age groups, but noted that a large number of young adults hadn’t made up their mind yet.

Patricia Smithson, 23, is a health care worker from Orlando, Florida, who overcame her initial hesitance about getting the COVID-19 vaccine after witnessing the deaths of people in her personal life.

Smithson, a health care worker from Orlando, Florida, was once among them. She was wary at first about rolling up her sleeve for the COVID-19 vaccine because of its rapid development and release.

“All of a sudden, there was this vaccine, out of nowhere,” Smithson said. “And it was made in less than a year; it was just a little bit of hesitancy about what exactly I was putting into my body.”

The turning point for Smithson was the number of people in her own life who died from COVID-19, including her aunt, Gloria. Smithson said she realized she “knew more people who died from COVID than people who died that received the vaccine.”

The memory of her aunt’s final days is haunting: “She was in the apartment sick for about three days before they rushed her to the hospital,” Smithson said. “And before they took her, they let my uncles and my cousins know, ‘Say your last goodbyes because this is probably the last that you’ll see her.’ And she died not too long after that.

“She was by herself; there was nobody with her. A good amount of the family wasn’t even able to go to the funeral because of everything that was going on. It was pretty tragic.”

COVID vaccine benefits vs. side effects

Smithson’s personal experience helped ease her concerns about the vaccine, but millions of young Americans remain uncertain. Experts told USA TODAY young adults face a torrent of misinformation about the vaccine from social media and a longstanding narrative that COVID-19 primarily sickens older adults.

And they’re being asked to make the decision amid a dizzying return to a more normal life as the nation largely drops pandemic restrictions.

Poynter – who works in Indiana as a patient care assistant – said she isn’t against vaccinations in general. But the COVID vaccine is too new for her to be comfortable having it in her body.

Romero – who works for UPS in Texas – will likely get the vaccine, but has decided to put it off. He likened that decision to waiting to buy a new gaming console “wait a little bit until like all the bugs were taken out.”

Benny Romero of Fort Worth, Texas shares why he hasn’t gotten the COVID-19 vaccine

CDC’s data shows those concerns are common: More than half of young adults surveyed who were undecided or likely to get vaccinated said they were concerned about possible side effects. A similar number said they planned to wait to see if the vaccine is safe.

Amy Middleman, who practices adolescent medicine with the University of Oklahoma Health Sciences Center and is a board member of the Unity Consortium, would urge young adults with those concerns to consider the documented health consequences of COVID-19.

“The benefits of vaccination clearly outweigh the risks at this time,” she said. Some of the concerns about long-term side effects she hears from patients are rumors not supported by science.

Young adults who have those fears should feel confident in the “incredibly thorough” review process for the vaccines and safety monitoring, Middleman said.

Fact-check: Are ‘permanent side effects’ a risk of the COVID vaccine?

Emails: Health officials halt vaccine events for teens amid conservative pressure

Tiffany Menendez, 24, had a similar thought process when she decided to get the vaccine.

The side effects she experienced were fleeting: “I only got a little bit sick, just for a day or two, but I hear with COVID … you get sick for quite a while and you even have side effects lingering in your body for longer than just a week or two, potentially for a lifetime,” Menendez told USA TODAY.

Masked students cross an intersection on the campus of Ball State University in Muncie, Ind., on Sept. 10, 2020.

“So, it’s very essential for me to get the vaccine … and not have that COVID sickness in my body.”

Dr. Shira Abeles, an infectious disease specialist with University of California San Diego Health, said those concerns are well-founded.

She remembers the horrific scenes of people in their 30s on ventilators who died. Others suffered “inexplicable fatigue” for months.

Meanwhile, the vaccine’s side effects can be managed with Tylenol. “It’s not like that with COVID,” she said.

Gen Z’s ‘altruistic’ vaccine motives

Many in Gen Z are thinking about their own health when making the decision to get vaccinated, but a regard for the well-being of others motivates some to get the vaccine.

Brittney Baack, an epidemiologist and co-author of the CDC report, told USA TODAY the study found that protecting friends and family was a top priority for young adults.

Klein said the generation’s motives are often “altruistic.”

Caroline Allen, a 21-year-old former University of Central Florida student, gladly rolled up her sleeve for the COVID-19 vaccine as a dedication to her grandmother who passed away from the virus.

Ellen Murray, 23, felt the weight of protecting her parents in Atlanta, who are in their 60s and more vulnerable to the virus, throughout the pandemic. That continued even after she got vaccinated because of the state’s low vaccination rates.

“I think the responsibility of somebody else’s health is just a lot more strenuous and it’s a lot more stressful to be worried about potentially – just like a very little mistake you make could have extreme disastrous effects on your parents’ health or your grandparents’ health,” she said.

Caroline Allen, 21, said she took every precaution to safeguard her health and relied on the guidance of the scientific community to navigate the uncertainty of the pandemic. Allen said she “wore my mask like it was my skin,” kept her social circle small and refrained from buying takeout meals from restaurants.

But when she got vaccinated in Orlando, she wasn’t thinking of herself: “I got it [the vaccine] for my grandmother,” Allen told USA TODAY.

Allen’s grandmother, Dorothy, who would have turned 100 in September, died from COVID-19 in January.

“She kept saying, ‘Well, I’m gonna be first in line when they pass out those vaccines,’ so I got it for her.”

This article originally appeared on USA TODAY: COVID vaccine: Gen Z isn’t in a hurry – but do they have time to wait?

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Mouse embryos grow for days in culture, but the requirements are a bit nuts

Enlarge / A mouse embryo with the nervous system highlighted in blue.

Embryos start out as a single cell, and have to go from there to a complicated array of multiple tissues. For organisms like insects or frogs, that process is pretty easy to study, since development takes place in an egg that’s deposited into the environment shortly after fertilization. But for mammals, where all of development takes place inside the reproductive tract, understanding the earliest stages of development is a serious challenge. Performing any experiments on a developing embryo is extremely difficult, and effectively impossible at some stages.

This week, however, progress has been made with both human and mouse embryos. On the human side, researchers have used induced stem cells to create embryo-like bodies that perform the first key step in development, catching them up to where mouse research has been for decades. On the mouse side, however, a research team has gotten mouse embryos to go for nearly a week outside the uterus. While that opens up a world of experiments that hadn’t previously been possible, the requirements for getting it to work means that it’s unlikely to be widely adopted.

To grow mice, you need rats

The mouse work was somewhat more interesting technically, so we’ll get to that first. One of the most critical steps in the development of vertebrates is called gastrulation. The process takes some cells that have been set aside during the early embryo, and converts them into three critical layers that go on to form the embryo: the skin and nerves, the lining of the gut, and everything else.

Gastrulation takes place between six and seven days after fertilization, and a lot of key developmental events take place shortly afterwards: the formation of nerve cells and their organization, the development of the ordered structures that form the vertebrae, and more. But, given the size of the embryo at this time and its location in the uterus, the process of gastrulation is essentially invisible.

A large team based in Israel decided to figure out how to change that. They first started with embryos that had already passed the critical stages of gastrulation, and figured out how to get them to survive. It was… not simple. To start with, they embryos had to be incubated in a bottle that constantly rotated in order to ensure all the nutrients and oxygen around the embryo were thorough mixed, instead of allowing the embryo’s energy demands to create a local “dead zone” around it.

The oxygen levels had to be controlled through a custom in-house gas supply system that ramped up the pressure over time in order to force more oxygen into solution. And fresh glucose had to be regularly infused into the liquid medium as well.

About that liquid medium. About a quarter of it was something you could buy out of a standard biotech supply catalog. The rest was substantially harder to come buy. Half of it was serum obtained from rat blood. And a quarter was serum obtained from human umbilical cord blood. Neither of these is particularly easy to come by. They tested, and you really do need the human blood; rat blood alone wasn’t nearly as good. (How often do I get to write a sentence like that?)

In any case, this was enough to get the embryos through four days of development. This took them from three layers of unspecialized cells to a place where the spinal cord had started to form and limbs started budding off the side of the embryo. That, in development terms, includes a whole lot of important events that we are very interested in studying.

But, by this point, the embryos growing circulatory system should have integrated with the placenta, ensuring the entire embryo was well supplied with nutrients and oxygen. The embryos died in a way that suggested an oxygen supply was probably lacking.

Earlier still…

While an accomplishment, this all takes place after gastrulation has happened. So, the researchers backed up a bit further, isolating embryos between four and five days after fertilization. The same medium worked, but here, the embryos didn’t need to be in a rotating bottle in order to survive. The two incubations could be combined, essentially taking the embryos through an entire week of development outside the uterus.

In addition, the team showed that they could perform a variety of manipulations on the embryos during this time in culture. This included inserting DNA into their cells (using either a virus or electrical currents), or adding in stem cells to see how they develop. So, for anyone willing to get enough rat and umbilical blood to make this all work, there’s a lot of developmental biology research that can now be done on mouse embryos.

The one thing that’s not obviously accessible through this work is the earliest developmental process, in which a cavity opens up in the uniform-looking ball of cells formed by the first cell divisions of the fertilized egg. This creates the first somewhat specialized populations of cells in the embryo (both the ones on the exterior, and a patch of cells inside the cavity). The resulting structure is called a blastocyst.

For mice, we’ve been able to take a fertilized egg and grow it into a blastocyst in culture for years. But this hasn’t been done with human cells. And, to a degree, it still hasn’t. Instead, two different labs started with stem cells, either embryonic stem cells or stem cells induced from adult tissues. In contrast to the mouse work, getting the embryo to go this far could be done with off-the-shelf ingredients in the media that the cells were grown in.

This opens up the earliest stages of human development to study. But, while formation of the blastocyst is interesting, a lot more goes on at later stages of development. And here, ethical concerns are likely to limit how far we’re going to be willing to take human tissue in culture.

The interesting thing here is that we can already get mouse embryos to develop into blastocysts, and now we can take blastocysts well on their way through development. So it seems likely that we can probably connect the two processes with a bit of work. That would be enough to get from fertilization through to about two-thirds of the way to birth. That’s pretty impressive.

But by this point, the embryo is getting very three-dimensional, and getting all the cells supplied with oxygen and nutrients really requires a functional blood supply, plugged into a source for all the embryos needs. And it’s not clear how exactly we could substitute for the placenta, which hosts a very elaborate and specialized interchange between the fetal and maternal blood streams. In practical terms, though, these results mean a whole range of experiments are now possible in mice—provided you’re willing to bleed enough rats.

Nature, 2021. DOI: 10.1038/s41586-021-03416-3, 10.1038/s41586-021-03372-y, 10.1038/s41586-021-03356-y  (About DOIs).

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Control Developer Says Sony Was ‘a Bit More Ready’ for Next-Gen Than Microsoft

Developing games for next-gen consoles is challenging, especially if you’re simultaneously developing them for current-gen, as Control developer Remedy was. But the PS5 and the Xbox Series consoles were not equally challenging to develop for, according to Remedy’s Thomas Puha.On Next-Gen Console Watch, Puha said that Sony was “a bit more ready” with its PS5 early tools for developers, and said that it was easier initially to get games like Control working on the PS5 than it was for the Xbox Series X and S.He did go on to say that both machines were still great to make games for, and while they’re both still working out system-level issues, this is normal for new hardware and things will ultimately get better with time.

“Sony stuck what worked, their development software and tools were pretty stable and good pretty early on,” Puha said. “Microsoft opted to change quite a lot of things, which in the long run are probably good, but of course it was just a bigger hurdle for us devs early on because we had to rewrite a bunch of different things to take advantage of specific features.”

Puha also had something to say about the Xbox Series S: namely, that developing for it is admittedly holding developers back at least a little.

“It’s no different from the previous generations where the system with the lowest specs does end up dictating a few of the things you’re going to do because you’re going to have to run on that system,” he said.

“The more hardware you have, the more you have to ultimately compromise a little bit when you are a smaller studio like us, when you just can’t spend as much time making sure all these platforms are super good.”

He added that quality assurance especially is a huge problem contributing to this, as it is more and more expensive to test games the more platforms you have to test them on.

“I don’t envy folks making Halo Infinite,” he said.

Control: Ultimate Edition is out now for PS5 and Xbox Series S and X, and seems to be running fine on both. The original version was our favorite game of 2019 with our original review at launch celebrating its weird world, its thrilling ranged combat, and its incredible cast, script, and secrets.

Rebekah Valentine is a news reporter for IGN. You can find her on Twitter @duckvalentine.



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Young woman mauled to death by bull mastiff rescue dog that ‘bit her arm off’ as neighbours tell of ‘horrific screams’

A YOUNG woman was mauled to death by a dog that “bit her arm off” as she lay in bed, according to local residents.

The woman, named locally as Keira Ladlow, was alone in the home when she was brutally attacked by the dog which is believed to be owned by a family member and lived at the address.  

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Keira Ladlow died after being attacked by the dogCredit: Facebook

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She was attacked as she lay in bedCredit: Facebook

Locals heard the girl scream and shout for help and the dog barking “incredibly loud”. 

Her body was found by a distraught relative. 

Police and paramedics rushed to the terraced home in Kitts Green, Birmingham, at around 2pm on Friday.

Keira, aged in her 20s, was pronounced dead at the scene by the emergency services. 

‘HEARTBREAKING’

The rescue dog, believed to be a bull mastiff, will now be “humanely” put down. 

A source said: “The poor girl was heard by neighbours screaming and shouting for help.

“The screams were extremely loud. They could also hear a dog in the house barking incredibly loud. It was constant. 

“The girl was very badly injured. It was horrific. It’s heartbreaking. Her family are totally devastated.”

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Neighbours described hearing ‘horrific screams’Credit: Facebook

Abeygail Barrett, believed to be a relative, wrote on Facebook: “Her previous dog was a pit bull that died of cancer so she rescued this dog after finding it in a garden where it had been on and off for four years.

“Sometimes dogs are rescued with all good intentions but their past can make them tragically unpredictable”.

One neighbour said: “When the police and ambulances came we were told to come outside because something had happened, then heard a young woman had died.

“I saw the dog being taken away and, as far as I can tell, it looked fine.

“I’d never seen it before and I heard from a neighbour it was only walked at certain times. She used to pull her own dog away from it because she thought it was violent.

“I saw on the news it was a Staffie, but to be it looked more like a Bull Mastiff.”

One distraught family member told the Sun: “It was a rescue dog, that’s it.”

A spokesperson for West Midlands Police said: “No one else was in the property at the time, and the woman’s family has signed the dog, believed to be a Staffordshire cross, over to police. It will be humanely put to sleep.

“The death is being treated as a tragic incident, but with no suspicious circumstances.

“A file will be prepared for the coroner in due course.”

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Removal people arrived at the house to take a bed awayCredit: Roland Leon

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The victim was pronounced dead at the scene by emergency servicesCredit: Roland Leon



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