Tag Archives: bacterium

What is Strep A, the common bacterium that has killed 6 children in the UK?


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CNN
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Health officials in the United Kingdom are advising parents and schools to watch for Strep A infections following the recent deaths of six children.

With Covid-19 restrictions such as masking and social distancing no longer required in the UK, infections such as Strep A are spreading more easily, with cases increasing over the past month.

Also known as Group A Streptococcus (GAS), Strep A can cause a range of symptoms varying from minor to severe but is not fatal for most people who become infected.

Strep A is a bacterium found in the throat and on the skin. It usually causes fever and throat infections, and many people carry it without any symptoms. However, they can still spread it to others through coughs, sneezes and close contact.

Symptoms of infection include pain when swallowing, fever, skin rashes and swollen tonsils and glands, with infection common in crowded settings such as schools and daycare centers, the US Centers for Disease Control and Prevention (CDC) says on its website.

“(Infection) tends to be fairly harmless,” Beate Kampmann, professor of Paediatric Infection & Immunity, and director of the Vaccine Centre at the London School of Hygiene & Tropical Medicine, said in a statement on Friday.

“(But) in very rare circumstances when the bacterium produces a toxin it can gain access to the bloodstream and cause really serious illness” such as sepsis, heart inflammation and toxic shock with organ failure, she said.

She advised parents to seek medical advice immediately if a child looks “very ill” with symptoms such as fever, vomiting, muscle aches or a rash.

Invasive Group A Streptococcus (iGAS) is the term used when the bacteria invade the body, overcoming its natural defenses to enter areas such as the blood, and is more dangerous, the UK Health Security Agency (UKHSA) explains on its website.

While there is no vaccine to prevent Strep A or iGAS infections, antibiotics are usually effective at treating them.

“We are seeing a higher number of cases of Group A strep this year than usual,” Colin Brown, deputy director at UKHSA, said in a statement on Friday.

The increase in iGAS this year has particularly been observed in children under 10, the UKHSA added. Five children have died in England. One death has been reported in Wales, according to Public Health Wales.

Data from UKHSA shows that there were 2.3 cases per 100,000 children aged 1 to 4 between mid-September and mid-November, compared with the average of 0.5 in the pre-pandemic seasons (2017 to 2019).

For children aged 5 to 9, there were 1.1 cases per 100,000, compared with the pre-pandemic average of 0.3.

The last period of high infections was between 2017 to 2018, with four children under 10 dying in the equivalent period, the statement added.

The UKHSA said it doesn’t believe a new strain is circulating, with the increase in infections likely a result of “circulating bacteria and social mixing.”

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New bacterium roughly the size, shape of an eyelash smashes size record

Ca. Thiomargarita magnifica, discovered in the French Caribbean mangroves is a member of the genus Thiomargarita.”/>
Enlarge / The bacteria, Ca. Thiomargarita magnifica, discovered in the French Caribbean mangroves is a member of the genus Thiomargarita.

Tomas Tyml

Clinging to sunken debris in shallow, marine mangrove forests in the French Caribbean, tiny thread-like organisms—perfectly visible to the naked eye—have earned the title of the largest bacteria ever known.

Measuring around a centimeter long, they are roughly the size and shape of a human eyelash, batting away the competition at 5,000 times the size of garden-variety bacteria and 50 times the size of bacteria previously considered giant. In human terms, this is akin to coming across a person as tall as Mount Everest.

Enlarge / Views of the sampling sites among the mangroves of Guadeloupe archipelago in the French Caribbean, April-May 2022.

Pierre Yves Pascal

Olivier Gros, a biologist at the University of the Antilles, discovered the prokaryotes in 2009, noticing them gently swaying in the sulfur-rich waters among the mangroves in the Guadeloupe archipelago. The bacteria clung to the leaves, branches, oyster shells, and bottles that sunk into the tropical swamp, Gros said in a press briefing.

He and colleagues first thought they might be complex eukaryotic organisms or perhaps a string of linked organisms. But years of genetic and molecular research revealed that each string is, in fact, one towering bacterial cell, genetically related to other sulfur-oxidizing bacteria. “Of course, this was quite a surprise,” Jean-Marie Volland, a microbiologist at the Joint Genome Institute in Berkeley, California, said in the briefing.

This week, Gros and colleagues published an article in Science laying out everything they’ve learned about the new, enormous bacteria, which they’ve dubbed Candidatus (Ca.) Thiomargarita magnifica.

Their findings expand our understanding of microbial diversity in ways microbiologists didn’t think possible. Scientists previously hypothesized that the size of bacteria would be limited by several factors, including a lack of intracellular transport systems, reliance on inefficient chemical diffusion, and a surface-to-volume ratio needed to satisfy energy needs. Yet, the volume of a single Ca. T. magnifica cell is at least two orders of magnitude higher than the predicted maximum that a bacterium can theoretically achieve, Volland said.

Volland, Gros, and colleagues are still learning how—and why exactly—Ca. T. magnifica manages its massive size. But, so far, it’s clear that Ca. T. magnifica oxidizes hydrogen sulfide from its sulfur-rich environment and reduces nitrate. About 75 percent of its cell volume is a sac of stored nitrate. The sac crushes up against the cell’s envelope, limiting the depth that nutrients and other molecules need to diffuse.

While bacteria tend to have free-floating DNA, Ca. T. magnifica appears to have more than half a million copies of its genome bundled up into numerous membrane-bound compartments that the researchers named pepins, after small seeds in fruit. The distribution of pepins throughout the bacteria’s outer edges could allow for localized protein production, eliminating the need to transport proteins long distances.

The next step to studying these gargantuan bacteria is for scientists to figure out how to culture them in labs. For now, the researchers have collected new specimens from the mangrove forests every time they run out. But, this has been tricky since they appear to have a mysterious life cycle or seasonality. For the last two months, Gros has not been able to find any. “I don’t know where they are,” he said.

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Scientists discover world’s largest bacterium, the size of an eyelash | Microbiology

Scientists have discovered the world’s largest known bacterium, which comes in the form of white filaments the size of human eyelashes, in a swamp in Guadeloupe.

At about 1cm long, the strange organism, Thiomargarita magnifica, is roughly 50 times larger than all other known giant bacteria and the first to be visible with the naked eye. The thin white strands were discovered on the surfaces of decaying mangrove leaves in shallow tropical marine marshes.

The discovery was a surprise because, according to models of cell metabolism, bacteria should simply not grow this big. Previously scientists had suggested an upper possible size limit about 100 times smaller than the new species.

“To put it into context, it would be like a human encountering another human as tall as Mount Everest,” said Jean-Marie Volland, a scientist at Lawrence Berkeley National Laboratory who co-authored the study.

Thiomargarita magnifica has been found to contain three times as many genes as most other bacteria. Photograph: Vol­lard et al.

The organism was discovered by Olivier Gros, a marine biology professor at the Université des Antilles in Guadeloupe, while searching for symbiotic bacteria in the mangrove ecosystem.

“When I saw them, I thought: strange,” said Gros. The lab first conducted microscopic analyses to establish that the strands were single cells. Closer inspection also revealed a strange internal structure. In most bacteria, the DNA floats around freely inside the cell. Thiomargarita magnifica appears to keep its DNA more organised inside membrane-bound compartments throughout the cell. “And this is very unexpected for a bacterium,” said Volland.

The bacterium was also found to contain three times as many genes as most bacteria and hundreds of thousands of genome copies spread throughout each cell, making it unusually complex.

Scientists are not yet sure how the bacteria evolved to be so big. One possibility is that it adapted to evade predation. “If you grow hundreds or thousands of times bigger than your predator you cannot be consumed by your predator,” said Volland.

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However, becoming big would have meant losing some of bacteria’s traditional advantages, including being uniquely able to move around and colonise new niches. “By leaving the microscopic world these bacteria have definitely changed the way they interact with their environment,” said Volland.

The bacteria have not yet been found in other locations – and had disappeared from the original site when the researchers returned recently, perhaps because they are seasonal organisms. But in the paper, published in the journal Science, the authors conclude that the discovery “suggests that large and more complex bacteria may be hiding in plain sight”.

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Biggest bacterium ever discovered amazes scientists with its complexity

Scientists discovered an absolutely massive bacterium that can be seen without the aid of a microscope and lurks among the mangroves of Grande-Terre in the Caribbean, Science magazine reported.

The single-celled organism can grow up to 0.78 inches (2 centimeters) long and resembles a thin string, according to a report describing the discovery, posted Feb. 18 to the preprint database bioRxiv. The bacterium carries all its DNA inside a membranous pouch, unlike most bacteria, whose genetic material floats, unbound, within their cells. This feature not only sets the newfound microbe apart from other bacteria, but also distinguishes it from other prokaryotes — a group of organisms with very small, simple cell structures. The group includes organisms found in the Bacteria and Archaea domains. 

In contrast to prokaryotes, eukaryotes, such as animals, plants and fungi, have more complex cells that contain a nucleus and other membrane-bound organelles. The newfound, enormous micobe toes the line between prokaryote and eukaryote in that it carries its DNA in a membrane-bound pouch, and it also carries a second, large pouch full of water, which takes up more than 70% of the cell’s total volume, Science reported. 

Related: 10 things we learned about microbes in 2021 

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This water-filled pouch squishes all the cell’s contents up against its outermost edge, which may help life-sustaining molecules diffuse into the cell more easily, while toxins pass easily out, Science reported.

A large, sulfur-eating bacterium in the genus Thiomargarita carries the same kind of water-filled pouch, and based on this similarity, plus a genetic analysis, the researchers concluded that the newfound bacterium might belong to the same genus. They proposed that the humongous microbe be named T. magnifica

The humongous bacterium “could be a missing link in the evolution of complex cells,” Kazuhiro Takemoto, a computational biologist at Kyushu Institute of Technology, told Science.

“All too often, bacteria are thought of as small, simple, ‘unevolved’ life-forms — so-called ‘bags of proteins,'” Chris Greening, a microbiologist at Monash University who was not involved in the study, told Science. “But this bacterium shows this couldn’t be much further from the truth.”

Read more about the expectation-defying microbe in Science

Originally published on Live Science. 



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