Tag Archives: appears

Oxford-AstraZeneca vaccine appears to substantially reduce coronavirus transmission, study shows

The rate of positive PCR tests declined by about half after two doses, according to preliminary results by researchers at the University of Oxford that have yet to be peer reviewed.

Their analysis, released as a preprint Tuesday, also supports spacing out doses and estimates good efficacy after just one shot of the Oxford-AstraZeneca vaccine.

The study did not measure transmission directly — for example, by tracing contacts who were infected by study volunteers. But the researchers did collect regular nasal swabs from some participants and found that the rate of positive PCR tests fell by half after two doses of the vaccine. After one dose only, the rate of positive tests fell by 67%.

“While transmission studies per se were not included in the analysis, swabs were obtained from volunteers every week in the UK study, regardless of symptoms, to allow assessment of the overall impact of the vaccine on risk of infection and thus a surrogate for potential onward transmission,” the authors write.

If the vaccine were simply making infections milder, PCR positivity would not change, the authors argued in the preprint analysis. “A measure of overall PCR positivity is appropriate to assess whether there is a reduction in the burden of infection.”

Coronavirus vaccine trials have primarily looked at prevention of symptomatic cases of Covid-19. Previously, there has been little other public data suggesting that vaccines could prevent people from passing the infection to others.

Speaking to the UK’s Science Media Centre (SMC), Helen Fletcher, professor of immunology at the London School of Hygiene and Tropical Medicine, said the data in the study “suggest a possibility that the vaccine could have an impact on transmission but further follow-up would be needed to confirm this.”

Dr. Doug Brown, chief executive of the British Society for Immunology, told the SMC the study “hints that the Oxford/AstraZeneca vaccine may be effective in stopping people being able to transmit the virus.”

He added: “While this would be extremely welcome news, we do need more data before this can be confirmed and so it’s important that we all still continue to follow social distancing guidance after we have been vaccinated.”

Dose spacing

The vaccine showed 66.7% efficacy against symptomatic disease starting two weeks after the second shot, researchers at the University of Oxford said.

The new analysis adds new trial sites and a month of new data to the mix, building upon earlier results announced by AstraZeneca that its vaccine had showed an estimated 70.4% efficacy.

However, the latest research also suggests the vaccine may offer substantial protection after a single shot.

The study estimates 76% efficacy up to three months following one dose. This is based on a subset of 88 symptomatic infections, split unevenly between the vaccine and placebo groups between 22 and 90 days after vaccination. The study also found relatively stable levels of antibodies during this time frame, “with minimal waning by day 90.”

Furthermore, the authors suggest there could be higher efficacy with more spaced-out doses. Among adults age 18 to 55, vaccine efficacy appeared to rise when the time between shots was spaced out from less than six weeks to more than 12. However, more information is needed to know how statistically different that finding is.

Taken together, the findings may bolster the UK’s decision to recommend spacing out doses up to 12 weeks apart, according to a statement from the chief investigator of the Oxford Vaccine Trial and co-author of the paper, Andrew Pollard.

“This is positive news as it shows that just one dose of this vaccine generates good levels of immunity and that this protection does not seem to wane in the shorter term,” said Brown, of the British Society for Immunology.

“In immunology terms, this finding is not unexpected as we know that some other vaccines confer better immunity when the doses are more spread out. Although further information is required to confirm these findings for older age groups, overall this new research should provide reassurance around the UK’s decision to offer the two doses of this vaccine 12 weeks apart.”

Similar data is not yet available on delaying the second dose of the Pfizer/BioNTech vaccine to 12 weeks after the first dose, said Dr. Gillies O’Bryan-Tear, past chair of policy and communications at the Faculty of Pharmaceutical Medicine in comments to the SMC. But, he added, “most commentators agree that it is likely to be the same with that vaccine, and indeed, other two dose vaccines.”

The authors caveat that the trials were not initially designed to evaluate efficacy by dose intervals, but the data “arose due to the logistics of running large-scale clinical trials in a pandemic setting.”

The primary analysis is based on 332 symptomatic infections that occurred among more than 17,000 trial volunteers in the UK, Brazil and South Africa more than two weeks after their second dose.

AstraZeneca announced last month it had completed enrollment in its Phase 3 trial in the United States, which will serve as “the primary basis” for the company’s eventual application to the US Food and Drug Administration.

The vaccine has already been authorized in a number countries, such as the UK and India, but authorization may not come in the US until late March at the earliest, according to Operation Warp Speed’s Moncef Slaoui.

Read original article here

Demi Moore’s face appears back to normal in new Fendi show image after sparking plastic surgery

She shocked fans while she appeared on the Fendi runway show on Wednesday during Haute Couture Fashion Week, sparking plastic surgery rumors.

But it appears the dramatic runway look was simply just due to an overly contoured face and makeup tricks, as Demi Moore’s face appeared to be back to normal in a new image.

On Friday, the 58-year-old actress shared a candid snap of herself posing with supermodels Christy Turlington and Kate Moss as well as Fendi’s artistic director Kim Jones.

She shocked fans while she appeared on the Fendi runway show on Wednesday during Haute Couture Fashion Week, sparking plastic surgery rumors. But it appears the dramatic runway look was simply just due to an overly contoured face and makeup tricks, as Demi Moore’s face appeared to be back to normal in a new image

The brunette beauty’s cheeks looked full and plump with no sign of the eye-catching defined cheekbones she had sported on the runway, as well as the downturned lips with the bottom lip much more fuller.

In the image, the mother of three looked pretty in glasses with no makeup on and her signature long brunette tresses sleek and loose around her.

The movie star grinned ear to ear in the Instagram image she posted on Friday, January 29, 2021 with the caption: ‘A lot of testing went into this group hug. Loved being part of the @fendi show with you @ctrulington and #kate moss. Thank you @mrkimjones,’ adding a heart emoji.

Demi sparked speculation that she has undergone plastic surgery after showing off a very dramatic new look on the Fendi runway at Haute Couture Fashion Week on Wednesday – leaving spectators stunned. 

All smiles: On Friday, the 58-year-old actress shared a candid snap of herself posing with supermodels Christy Turlington and Kate Moss as well as Fendi’s artistic director Kim Jones

The actress was almost unrecognizable as she joined a host of A-list models on the catwalk for designer Kim Jones’ Fendi Spring Summer 2021 presentation in Paris on Wednesday, and left many social media users questioning whether her transformation has come as the result of cosmetic enhancements, or ‘terrible’ makeup.  

Within minutes of Demi’s appearance on the couture catwalk – for which she modeled a plunging black satin blouse and large statement earrings – Twitter had been flooded with questions from perplexed users about the Striptease star’s new look.   

Makeup: The actress was almost unrecognizable as she joined a host of A-list models on the catwalk for designer Kim Jones’ Fendi Spring Summer 2021 presentation in Paris on Wednesday, and left many social media users questioning whether her transformation has come as the result of cosmetic enhancements, or ‘terrible’ makeup 

Shock: Soon after images of Demi appeared online, social media users expressed their shock over her dramatic new look, with some questioning whether she has had surgery

Questions: Other social media users queried whether her transformation had come as the result of ‘terrible’ makeup , which appears to be the case

Upset: One social media user expressed concern for Demi, suggesting that she had transformed her face because she was struggling with her ‘confidence’ 

‘I wouldn’t have thought that was Demi Moore without the headline,’ one user wrote in reaction to a news story about the actress’s surprise catwalk appearance. ‘Is that all bad fillers? Or is there some horrible contouring happening there also? 

‘That face just doesn’t look right but I can’t figure out if it’s all plastics or of the makeup artist was doing something odd.’ 

Another cheekily wrote: ‘Demi NoMoore plastic surgery! That’s a shame! I wish women would allow themselves to age gracefully. 

‘It’s so much more attractive than when they start messing with their face.’ 

Makeup magic: Demi (seen left in February 2020), 58, sparked rumors that she’s had plastic surgery when she showed off a dramatic new look in Paris on Wednesday (right) but it now appears to be due to over contouring and makeup

‘Demi Moore unfortunately who used to be beautiful is now just a poster child for why not to get plastic surgery,’ said one comment.  

One person expressed their upset over Demi’s changed appearance, commenting: ‘This is total self destruction. This is painful insecurity. This is total lack of confidence. What in the world would make you do that to your own face?’  

Others simply voiced their shock over the images of the Striptease star on the runway, with many admitting that they didn’t initially recognize Demi.  

Working it: Demi made her mark in the style industry as she ruled the catwalk for Kim Jones’ Fendi Spring-Summer presentation during Paris Haute Couture Week on Wednesday

Turning heads: The actress, 58, caught the eye as she was dressed in a satin black blouse, complete with a peplum hemline

Way back when: Demi (pictured left in 1993 and right in 1996) has long been known for maintaining incredibly youthful looks, having been in the spotlight since the early 90s 

Rumors: The actress was plagued by reports in the early 2000s that she’d had $250,000 worth of plastic surgery ahead of her appearance in Charlie’s Angels: Full Throttle (pictured)

Shut down: Demi (pictured in July 2020) denied the surgery reports in a 2007 interview, insisting that she had ‘never’ gone under the knife for a cosmetic procedure

‘I cannot believe this is Demi Moore,’ someone said, while another agreed, writing: ‘That can’t be Demi Moore. I had a huge crush on her.’ 

The latest images of Demi reveal a very changed appearance that that seen in the candid snaps the actress has been sharing from home throughout the pandemic – many of which have shown her with no makeup on while lounging around with her family.  

Demi has long been known for her age-defying looks, and has often stunned with her ever-youthful appearance and impressively trim and toned physique, which she has maintained for decades. 

However this is not the first time that she has had to face rumors about whether she has undergone cosmetic surgery.  

It was widely reported almost 20 years ago that Demi had spent nearly $250,000 on plastic surgery to complete transform her face and body ahead of her appearance in the 2003 movie Charlie’s Angels: Full Throttle, however she shut down the reports as nothing more than speculation, insisting in 2007 that she had ‘never’ had any cosmetic surgery. 

‘I don’t like the idea of having an operation to hold up the aging process – it’s a way to combat your neurosis,’ she said at the time. ‘The scalpel won’t make you happy.’   

During a 2019 interview with the Daily Mirror, Demi said that she is ’embracing’ the natural aging process, despite admitting that there were times when she looked in the mirror and didn’t recognize herself. 

‘Gravity is going in some directions I’m not fond of. I can look in the mirror ­occasionally and say, “You’re lying, I don’t look like that,”‘ the Ghost star explained.  

Confusion: Twitter was flooded with posts about Demi’s new look, with many remarking on her unrecognizable appearance, while others asked what was behind it 

Speculation: Many Twitter users questioned whether Demi had undergone plastic surgery, while others suggested that her dramatic new look may have been due to ‘horrible’ makeup

All eyes on her: The producer teamed the bold piece with a pair of wide-leg trousers and ensured focus remained on her outfit by ditching bracelets and necklaces

All eyes on her: Exuding edgy chic, the screen star’s shirt featured a low-cut neckline, which highlighted her cleavage

Great idea: Models stayed socially distanced from one another amid the global coronavirus pandemic as they stood inside giant perspex letters which spelled out the word ‘Fendi’

‘But I feel for myself it’s about acceptance… embracing it and no longer looking for what’s wrong – just being accepting of everything.’ 

The mother-of-three’s appearance on the runway comes after a low-key few months for Demi, who has spent much of the pandemic hunkering down at home with her family. 

Despite the controversy over her new look, Demi certainly stood her own during the fashion show while modeling alongside A-list fashion stars like Kate Moss and Bella Hadid. 

Demi’s enviable figure was accentuated by the plunging neckline of her black silk blouse, which nipped in at the waist, and left her decolletage and shoulders bare.  

Her long bell-bottom sleeves covered her hands, while the peplum finish helped to emphasize her curves. 

The form-flattering blouse was paired with matching wide-leg trousers, and Demi’s look was completed with some plain black shoes, and some very large statement earrings that dangled down to her armpits. 

She also modeled a chunky cuff on her left ear that sparkled under the glare of the spotlights – which also helped to accentuate Demi’s pronounced cheek bones and plump pout. 

Her youthful-looking complexion was given an extra boost courtesy of some simply yet chic dewy make-up.   

Sticking to the rules: Demi sensibly covered her face with a mask as she left the show following her catwalk appearance 

No rest for the wicked: The producer arrived in France with her daughter Scout Willis and other A-list stars on Tuesday (pictured)

The mother-of-three is not a newcomer to the runway having recently starred in Rihanna’s Savage x Fenty showcase. 

Models stayed socially distanced from one another amid the global coronavirus pandemic as they stood inside giant perspex letters which spelled out the word ‘Fendi’.  

British designer Kim, who joined Italian fashion house Fendi as its lead designer for womenswear in September 2020, and continues to fulfil his role as artistic director at Dior Men’s.

The fashion expert succeeds the late Karl Lagerfeld in his Fendi role, which the designer held from the mid-1960s. 

Chanel designer Karl sadly passed away aged 85 from complications of pancreatic cancer on February 2019. 

Supermodel Kate Moss told Vogue ahead of the show: ‘I always wanted to wear his [Kim’s] menswear – and now he’s making womenswear!’  

How Demi usually looks: The star was seen promoting her book Inside Out last year

The fashion icon, 47, was one of Jones’s muses for the latest collection, and one of his best friends, and the publication notes that she modeled his clothing at Charleston, in the March 2021 issue. 

‘It’s quite a challenge,’ said Antoine Arnault, the LVMH group head of communications and chief executive of Berluti, who has known Mr. Jones since they worked together at Vuitton. 

The businessman told the New York Times: ‘Mr. Jones is one of our superstars. When you have a top footballer on your team, you want to let him play to to his full potential.’  

Ralph Lauren, Giorgio Armani, Raf Simons and Hedi Slimane have all made the leap from menswear to womenswear.

The site reports that Fendi surpassed a billion euros in revenue in 2017 (about $1.2 billion) to become one of the more important brands in the LVMH portfolio.

Read original article here

Tom Brady-Bill Belichick debate appears to be over for some after NFL star’s NFC Championship victory

Who was responsible for the New England Patriots’ success? Was it Tom Brady or Bill Belichick?

That was the underlying question heading into the 2020 season after Brady moved on from the Patriots in the offseason to join the Tampa Bay Buccaneers on a 2-year deal. Brady won six Super Bowl championships in New England but when he left the debate raged with many asserting that it was Belichick’s system that made Brady what he was.

CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM

After an 11-5 record and an NFC Championship, the debate appeared to be settled for some. It was Brady all along.

The 2020 season didn’t start off great for Brady. The Buccaneers lost 34-23 to the New Orleans Saints while the Patriots, with Cam Newton at the helm, defeated the Miami Dolphins 21-11. But everything appeared to change after the first week of the season.

TOM BRADY HAS HEARTFELT MOMENT WITH SON FOLLOWING NFC CHAMPIONSHIP VICTORY

Tampa Bay would win seven of their next eight games while the Patriots would win only three of their next eight. The Buccaneers stayed in contention for the NFC South division title, only losing it by a game after getting swept by the Saints. The Patriots would lose three of their last four to end the season.

Brady would then lead Tampa Bay to three consecutive wins on the road to get to the Super Bowl and win his first NFC Championship, tying Drew Brees and Aaron Rodgers’ totals.

CLICK HERE TO GET THE FOX NEWS APP

Brady and the Buccaneers will have their hands full with the Kansas City Chiefs, but as far as the debate over who made who’s success, it appears Brady might have the upper hand.

Read original article here