Tag Archives: affected

Over 1 in 3 people affected by neurological conditions, the leading cause of illness and disability worldwide – World Health Organization (WHO)

  1. Over 1 in 3 people affected by neurological conditions, the leading cause of illness and disability worldwide World Health Organization (WHO)
  2. Neurological conditions now leading cause of ill-health worldwide, finds study The Guardian
  3. Neurological conditions now leading cause of ill health and disability globally, new analysis finds Medical Xpress
  4. Nervous system disorders found to be biggest cause of poor health Financial Times
  5. Brain stroke, Alzheimer’s and diabetic nerve damage going up sharply: What a new Lancet neuro study means The Indian Express

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‘Eternals’ Actor Kumail Nanjiani Says His Mental Health Was Affected After Negative Reviews For Marvel Film: “I Still Talk To My Therapist About That” – Deadline

  1. ‘Eternals’ Actor Kumail Nanjiani Says His Mental Health Was Affected After Negative Reviews For Marvel Film: “I Still Talk To My Therapist About That” Deadline
  2. Kumail Nanjiani Began Counselling to Address Trauma from Marvel’s Eternals Backlash IGN
  3. Kumail Nanjiani Goes to Therapy Every Week for ‘Untenable’ Anxiety: ‘A Constant Thing’ PEOPLE
  4. Kumail Nanjiani Reveals He Went to Counseling Over ‘Eternals’ Bad Reviews: “I Do Have Trauma” Hollywood Reporter
  5. Kumail Nanjiani Reveals How ‘Eternals’ Backlash Landed Him In Therapy HuffPost

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Trump brags about bringing ‘Trump water’ to families affected by Ohio train derailment – The Independent

  1. Trump brags about bringing ‘Trump water’ to families affected by Ohio train derailment The Independent
  2. Donald Trump Speech Today | Trump Visits Ohio Train Derailment Site | Trump In Ohio | News18 LIVE CNN-News18
  3. Donald Trump remarks in East Palestine, Ohio following train derailment disaster | LiveNOW from FOX LiveNOW from FOX
  4. Political action committee criticizes Trump era railroad deregulation in wake of East Palestine visit WFMJ
  5. Why Joe Biden should be worried about Trump’s trip to Ohio The Independent
  6. View Full Coverage on Google News

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Ernie Hudson Says ‘Ghostbusters’ Affected Him Psychologically: “It Wasn’t an Easy Road” – Hollywood Reporter

  1. Ernie Hudson Says ‘Ghostbusters’ Affected Him Psychologically: “It Wasn’t an Easy Road” Hollywood Reporter
  2. Ernie Hudson: being “pushed aside” in Ghostbusters “felt deliberate” The A.V. Club
  3. ‘Ghostbusters’ Actor Ernie Hudson Recalls Being “Selectively Pushed Aside” By The Studio & Says Changes Were Made To Script After He Joined Deadline
  4. Ernie Hudson Says ‘Ghostbusters’ Script and Marketing Pushed Him Aside: ‘It Felt Deliberate’ and ’I’m Still Not Trying to Take It Personally’ Variety
  5. Ghostbusters Star Ernie Hudson Recalls Being “Selectively Pushed Aside” by the Studio ComicBook.com
  6. View Full Coverage on Google News

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How covid affected Jacinda Ardern’s legacy as New Zealand prime minister

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SYDNEY — Jacinda Ardern was on a work trip to a beach town in northern New Zealand almost exactly a year ago when her van was suddenly surrounded by anti-vaccine protesters. They called the prime minister a “Nazi” for requiring some workers get a coronavirus vaccine, and chanted “shame on you.” Some screamed obscenities. When a car tried to block Ardern’s exit, her van was forced to drive onto the curb to escape.

When asked about the incident a few days later, Ardern chuckled and shrugged it off.

“Every day is faced with new and different experiences in this job,” she said. “We are in an environment at the moment that does have an intensity to it that is unusual for New Zealand. I do also believe that with time it will pass.”

New Zealand Prime Minister Jacinda Ardern resigns ahead of election

A little more than a month later, however, protests outside Parliament against vaccine mandates literally exploded into flames. Demonstrators set their own tents and gas canisters ablaze. Protesters pelted police with the same paving stones on which they’d written warnings to Ardern and other politicians that they’d “hang them high.” More than 120 people were arrested.

This time, Ardern didn’t shrug. Instead, she seemed angry and baffled.

“One day, it will be our job to try to understand how a group of people could succumb to such wild and dangerous mis- and disinformation,” she said.

In the end, New Zealand’s new era of intense rhetoric and dangerous disinformation will outlast Ardern, who announced Thursday that she was stepping down after more than five years in office.

“I know what this job takes,” the 42-year-old said in an emotional resignation speech. “And I know that I no longer have enough in the tank to do it justice.”

Ardern didn’t mention the protests or the extreme rhetoric or the threats she faced. But she did mention the coronavirus pandemic. And in many ways, her management of the health crisis was her greatest success, but also made her a divisive figure in New Zealand.

“I think it will probably be her greatest legacy,” said Michael Baker, an epidemiologist who served as an outside adviser to Ardern’s government during the pandemic. He likened Ardern to Winston Churchill, who shepherded the United Kingdom though World War II only to lose the 1945 election.

“It’s very hard to even imagine navigating through such an extreme threat that has been so prolonged,” he said. “At the end of it there was a deep bitterness over the experience people had been through, and unfortunately to some extent it’s been directed at her even though she’s done an extraordinary job.”

Ardern acted quickly at the outset of the pandemic, closing her country’s borders to foreigners even though tourism is one of New Zealand’s biggest industries. That decision, coupled with stringent quarantine requirements for returning New Zealanders and snap lockdowns, kept her country largely covid-free until early last year.

5 moments that defined Jacinda Ardern’s time as New Zealand prime minister

By the time the virus did become widespread in New Zealand, the vast majority of adults had been immunized. As a result, the country of about 5 million people has recorded fewer than 2,500 covid-19 fatalities — the lowest covid-related death rate in the Western world, according to Johns Hopkins University.

New Zealand’s mortality rate is still so low that fewer people have died than in normal times, Baker noted.

For almost two years, the charismatic Ardern was the global face of “zero covid”: an approach that drew admiration from other countries and also seemed to dovetail with her personal style of consensus-based governance. In the fight against covid, she referred to New Zealanders as “our team of 5 million.”

But that sense of team unity began to fray in late 2021, when Ardern introduced requirements that some types of workers be vaccinated, and that proof of vaccination be shown to enter gyms, hairdressers, events, cafes and restaurants.

“From a public health view it saved many lives, but it had this political cost,” Baker admits. “It probably contributed to the intensity of the anti-vaccine movement in that it was seized on by some groups who called it the ‘overreach’ of the state.”

The same policies that made New Zealand and its prime minister a zero-covid success also made Ardern a lightning rod for anti-lockdown and anti-vaccine ardor.

“Because she was such a global and public symbol, she did become the focus of a lot of those attacks,” said Richard Jackson, professor of peace studies at the University of Otago.

“Their opinion was that she was destroying New Zealand society and bringing in ‘communist rule’ and yet the whole world seemed to be praising her and lauding her,” he added. “It irritated the hell out of them.”

Sexism dogged Jacinda Ardern’s tenure. Battling it is part of her legacy.

Protesters began following her around the country, from the van incident in the northern seaside town of Paihia in January last year to a similar incident in the South Island a few weeks later, when Ardern visited an elementary school only to be called a “murderer” by protesters waiting outside.

By then, hundreds of anti-mandate and anti-vaccine protesters had gathered on the lawn of Parliament in Wellington. Some put up signs that mocked Ardern in misogynistic fashion or compared her to Hitler. Others hung nooses reminiscent of the Jan. 6, 2021, assault on the American capital.

The rise in extremist rhetoric and baseless theories in New Zealand has been partly fueled by far-right movements in the United States and Europe, Jackson said, including pundits such as Tucker Carlson, who often took aim at Ardern. The prime minister herself called it an “imported style of protest that we have not seen in New Zealand before.”

After increasingly aggressive behavior by the protesters, including some hurling feces at police, officers in riot gear began to clear Parliament grounds on the morning of March 2. Some protesters fought back, turning their camping equipment into incendiary weapons.

Ardern reminded people that “thousands more lives were saved over the past two years by your actions as New Zealanders than were on the front lawn of Parliament today.”

New Zealand police battle protesters as tents burn, Parliament camp is cleared

In the eyes of some, however, the moment marked a turning point for the country.

“The nooses, the misogyny, the hate, the level of people advocating violence, people threatening to hang politicians, that’s not part of the New Zealand tradition of politics,” said Alexander Gillespie, professor of law at the University of Waikato.

“It was a huge shock to the country,” said Jackson, who described the protests as the most violent since clashes during the 1981 visit of the apartheid-era South African rugby team. “The way it ended I think kind of brought home to everyone that what we thought of as quite moderate and peaceful and tolerant politics might have ended, and we now have a much more intense, polarized and extreme” atmosphere, he said.

The vitriol continued even after her announcement Thursday: The owner of a bar in Nelson posted a doctored photo of Ardern in a wood chipper being towed by a hearse, but took it down after receiving complaints.

In recent months, Ardern’s broader popularity had begun to slip. The Labour Party she led to a sweeping and historic victory little more than two years ago now trails its rival in the polls, and her party is widely expected to lose this year’s election.

Like Churchill, Ardern had led her country through a dark time, but eventually lost the support of a crisis-weary populace, Baker said.

But the decision appears to have removed a weight from the prime minister’s shoulders. She told reporters Friday morning that she’d “slept well for the first time in a long time.”

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AMD partner suspects a faulty batch of reference Radeon 7900 GPUs is affected by thermal issues

Please note that this post is tagged as a rumor.

There might be a fault batch of reference AMD Radeon 7900 GPUs

Igor Wallossek has provided a brief update to Der8auer findings.

As a reminder, Der8auer has recently posted a video focusing on AMD Radeon 7900 reference card thermal throttling related issues. Although he has not yet provided a full explanation, he claims that it is very likely that a faulty vapor chamber might be the main culprit behind GPU hot spot issues and as a result, thermal throttling.

Today Igor weighs in by sharing a note from a board partner. It is reported that the undisclosed OEM suspects at least one faulty batch of Radeon 7900 series might have left the factory. The possible issue being described is insufficient coolant added to the vapor chamber.

Possible explanation of Radeon 7900 thermal problem, Source: Igor’sLAB

Igor does not want to spoil the der8auer’s new findings, so what is important is that the YouTuber is to share a new video tomorrow which should provide us more information.

For those affected it is really too early to tell if these claims are even true. And even if there is a faulty batch of Radeon 7900 reference cards, it is not clear how many were made and where they were sent to yet.

Source: Igor’sLAB via ComputerBase



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Hong Kong asks Japan to drop airport bans, 60,000 travellers affected

HONG KONG, Dec 29 (Reuters) – Hong Kong has asked Japan to withdraw a COVID-19 restriction that allows passenger flights from the financial hub to land only at four designated airports, saying the decision would affect about 60,000 passengers.

India, Italy, Taiwan and the United States require mandatory COVID-19 tests on travellers from China after Beijing’s decision last month to lift stringent zero-COVID policies that fuelled a surge in infections across mainland China.

Hong Kong, home to more than 7 million people, is recording around 20,000 coronavirus cases a day but lifted its COVID curbs on Thursday for the first time in three years.

Japan, a top travel destination for those in Hong Kong, said it would limit flights from Hong Kong, Macau and mainland China to Tokyo’s two airports, as well as Osaka and Nagoya, from Friday.

The decision comes during a peak travel season ahead of the Lunar New Year holiday which begins on Jan. 21.

“It is understood that around 250 outbound flights of Hong Kong airlines will be affected between December 30, 2022 and the end of January 2023, affecting around 60,000 passengers,” the government said in a statement late on Wednesday.

City leader John Lee said the government had indicated to Japan that it was disappointed.

“We think that Hong Kong people should be allowed to use not just these four airports,” Lee said.

On Thursday, Hong Kong’s government said Japan would let passenger flights from Hong Kong also land in Hokkaido, Fukuoka and Okinawa provided that no passengers aboard had been in mainland China for the prior seven days, but said the condition was “unreasonable”.

Flights of Hong Kong airlines can still carry passengers back to Hong Kong from airports in Japan, the government said, to ensure their smooth return and “minimise the impact to Hong Kong travellers caused by the incident.”

In a statement, Hong Kong’s flagship carrier Cathay Pacific Airways (0293.HK) said it would continue to operate flights to Japan, although it would reduce these to 65 a week, down 20% from its planned schedule for Jan 2023.

HK Express, which is owned by Cathay, said in a separate statement it would only be able to operate 60 scheduled flights a week to destinations in Japan due to the curbs, prompting the cancellation of 41 flights from Hong Kong to Japan in January.

Hong Kong Airlines and Peach Aviation said they would cancel some flight routes because of the rules.

In December, China began dismantling the world’s strictest COVID regime of lockdowns and extensive testing, putting its battered economy on course for a complete re-opening next year.

The lifting of curbs following widespread protests has meant that COVID is spreading largely unchecked, probably infecting millions of people each day, some international health experts have said.

Reporting by Farah Master and Twinnie Siu; Editing by Lincoln Feast and Stephen Coates

Our Standards: The Thomson Reuters Trust Principles.

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Thousands of turkeys affected after bird flu hits Pennsylvania’s popular Jaindl Farms

NORTH WHITEHALL TWP., Pennsylvania (WPVI) — A popular Lehigh Valley turkey farm had to destroy thousands of turkeys after the bird flu disease was detected in a flock.

David Jaindl of Jaindl Farms in Orefield, Pa. says 14,000 turkeys were affected.

According to the USDA, the agency that tracks the cases, 21 commercial flocks have been affected in Pennsylvania.

Similar outbreaks are happening across the country.

Prior to the impact, Jaindl sat down for an interview where he spoke about the flu and inflation.

“It’s tough because the product is limited across the country so you’re going to see higher prices this year,” Jaindl said.

Authorities are setting up a control area and surveillance zone around the farm to hopefully prevent the flu from spreading.

Many of the Jaindl turkeys intended for Thanksgiving were processed before the outbreak, Jaindl said.

Jaindl has supplied turkeys to the White House in the past.

“We are confident that we will have an adequate supply of turkeys for the Thanksgiving holiday,” Jaindl said.

Jaindl says bird flu issues have reached 46 states and have affected 50 million birds across the country since February.

The bird flu and inflation are hiking the costs of turkeys across the country.

Data from the USDA shows a dramatic increase in the cost of fresh turkey after the 2015 bird flu outbreak — and an even higher jump after this year’s outbreaks.

Pennsylvania poultry operations continue to experience threats from highly pathogenic avian influenza (HPAI). The disease is highly contagious to birds and almost always fatal, according to the state Department of Agriculture.

According to the CDC, there are no reports of any human cases of the avian flu in the United States.

Copyright © 2022 WPVI-TV. All Rights Reserved.



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Motivation Is Affected by Oxidative Stress, but Nutrition Can Help

Summary: Higher levels of glutathione in the nucleus accumbens correlated with better and more steady performance in motivation-based tasks. Findings suggest improvements in accumbal anti-oxidant function that can be acquired via diet or supplementation may be a feasible approach to help boost motivation.

Source: EPFL

In life, motivation can be the difference between success and failure, goal-setting and aimlessness, well-being and unhappiness. And yet, becoming and staying motivated is often the hardest step, a problem which has prompted much research.

A very small part of that research has looked into the question of metabolism. “Do differences in metabolites in the brain affect our capacity for motivation?” asks Professor Carmen Sandi at EPFL’s School of Life Sciences. “If that is the case, could nutritional interventions that can affect metabolite levels be an effective vehicle to improve motivated performance?”

Sandi’s group, with their colleagues at the Nestlé Institute of Health Sciences, have now published a study that shines the first light into answering that question. The researchers focused on an area deep into the brain called the “nucleus accumbens”, which is known to play a major role regulating functions like reward, reinforcement, aversion, and not least, motivation.

Metabolism and oxidative stress in the brain

The idea behind the study was that the brain itself—like all tissues in our body—is subjected to constant oxidative stress, as a result of its metabolism.

What is oxidative stress? As cells “eat” various molecules for fuel, they produce a number of toxic waste products in the form of highly reactive molecules collectively known as “oxidative species”. Of course, cells have a number of mechanisms in place to clear oxidative species out, restoring the cell’s chemical balance. But that battle is ongoing, sometimes that balance is disturbed and that disturbance that’s what we call “oxidative stress”.

The glutathione connection

The brain then is often subjected to excessive oxidative stress from its neurometabolic processes—and the question for the researchers was whether antioxidant levels in the nucleus accumbens can affect motivation. To answer the question, the scientists looked at the brain’s most important antioxidant, a protein called glutathione (GSH), and its relationship to motivation.

“We assessed relationships between metabolites in the nucleus accumbens—a key brain region—and motivated performance,” says Sandi. “We then turned to animals to understand the mechanism and probe causality between the found metabolite and performance, proving as well that nutritional interventions modify behavior through this pathway.”

Tracking GSH in the nucleus accumbens

First, they used a technique called “proton magnetic resonance spectroscopy,” which can assess and quantify the biochemistry in a specific region of the brain in a non-invasive way.

The researchers applied the technique to the nucleus accumbens of both humans and rats to measure the levels of GSH. They then compared those levels to how well or poorly their human and animal subjects performed in standardized, effort-related tasks that measure motivation.

What they found was that higher levels of GSH in the nucleus accumbens correlated with better and steady performance in the motivation tasks.

GSH levels and motivation

But correlation does not imply causation, so the team moved on to live experiments with rats that were given micro-injections of a GSH blocker, downregulating the synthesis and levels of the antioxidant. The rats now showed less motivation, as seen in a poorer performance in effort-based, reward-incentivized tests.

Cysteine is contained in ‘high-protein foods’, such as meat, chicken, fish or seafood. Image is in the public domain

On the contrary, when the researchers gave rats a nutritional intervention with the GSH precursor N-acetylcysteine—which increased GSH levels in the nucleus accumbens—the animals performed better. The effect was “potentially mediated by a cell-type specific shift in glutamatergic inputs to accumbal medium spiny neurons,” as the authors write.

Can nutrition or supplements help motivation?

“Our study provides novel insights on how brain metabolism relates to behavior and puts forward nutritional interventions targeting key oxidative process as ideal interventions to facilitate effortful endurance,” conclude the authors. The study’s findings “suggest that improvement of accumbal antioxidant function may be a feasible approach to boost motivation.”

“N-acetylcysteine, the nutritional supplement that we gave in our study can also be synthesized in the body from its precursor cysteine,” says Sandi. “Cysteine is contained in ‘high-protein foods’, such as meat, chicken, fish or seafood. Other sources with lower content are eggs, whole-grain foods such as breads and cereals, and some vegetables such as broccoli, onions, and legumes.”

“Of course, there are other ways beyond N-acetylcysteine to increase GSH levels in the body, but how they relate to levels in the brain—and particularly in the nucleus accumbens—is largely unknown. Our study represents a proof of principle that dietary N-acetylcysteine can increase brain GSH levels and facilitate effortful behavior.”

See also

About this motivation and neuroscience research news

Author: Press Office
Source: EPFL
Contact: Press Office – EPFL
Image: The image is in the public domain

Original Research: Open access.
“Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort,” by Ioannis Zalachoras et al. eLife


Abstract

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance.

However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes and whether antioxidant levels in the nucleus accumbens contribute to motivated performance is not known.

Here, we identify a critical role for glutathione (GSH), the most important endogenous antioxidant in the brain, in motivation.

Using proton magnetic resonance spectroscopy (1H-MRS) at ultra-high field in both clinical and preclinical populations, we establish that higher accumbal GSH levels are highly predictive of better, and particularly steady performance over time in effort-related tasks.

Causality was established in preclinical in vivo experiments that, first, showed that down-regulating GSH levels through micro-injections of the GSH synthesis inhibitor buthionine sulfoximine in the nucleus accumbens impaired effort-based reward-incentivized performance.

In addition, systemic treatment with the GSH precursor N-acetyl-cysteine (NAC) increased accumbal GSH levels and led to improved performance, potentially mediated by a cell-type specific shift in glutamatergic inputs to accumbal medium spiny neurons. Our data indicate a close association between accumbal GSH levels and individual’s capacity to exert reward-incentivized effort over time.

They also suggest that improvement of accumbal antioxidant function may be a feasible approach to boost motivation.

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Hands of People With Diabetes More Often Affected by Trigger Finger

Summary: Trigger finger, a condition in which the fingers get locked into a bent position and become difficult to straighten, is more common in those with diabetes than in the general population. High blood sugar levels increase the risk of developing trigger finger, researchers say.

Source: Lund University

Locked fingers, known as trigger finger, are more common among people with diabetes than in the general population. A study led by Lund University in Sweden shows that the risk of being affected increases in the case of high blood sugar. The study has been published in Diabetes Care

Trigger finger means that one or more fingers, often the ring finger or thumb, ends up in a bent position that is difficult to straighten out. It is due to the thickening of tendons, which bend the finger, and their connective tissue sheath, which means that the finger becomes fixed in a bent position towards the palm. It is a painful condition that can often be treated with cortisone injections, but sometimes requires surgery.  

“At the hand surgery clinic, we have noted for a long time that people with diabetes, both type 1 and type 2, are more often affected by trigger finger. Over 20 percent of those who require surgery for this condition are patients who have, or will develop, diabetes,” says Mattias Rydberg, doctoral student at Lund University, resident physician at Skåne University Hospital and first author of the study.

To study whether high blood sugar (blood sugar dysregulation) increases the risk of trigger finger, the researchers examined two registers: Region Skåne’s healthcare database, which includes all diagnoses, and the Swedish national diabetes register. Between 1 and 1.5 percent of the population are affected by trigger finger, but the diagnosis arises among 10-15 percent of those who have diabetes, and the phenomenon appears most in the group with type 1 diabetes. 

The newly published study strengthens the pattern of blood sugar being a crucial factor for an increased risk of being affected by trigger finger. High blood sugar increased the risk of being affected by trigger finger among both men and women in the groups with type 1 diabetes and type 2 diabetes.

Blood sugar is measured in HbA1C, also referred to as long-term blood sugar, and when regulated, is under 48. The group of men with the worst regulated blood sugar (HbA1C > 64) had up to 5 times as high a risk of being affected than men with well-regulated (HbA1< 48) blood sugar. 

“However, we can’t know for certain if any of the groups seek healthcare more often than others which could be a factor that affects the results,” says Mattias Rydberg. 

The mechanism, or mechanisms, behind the increased risk are unknown, but there are theories that high blood sugar makes both the flexor tendons and their connective tissue sheaths thicker, thus causing them to lock more easily. It was previously known that those with unregulated blood sugar are more prone to nerve entrapments in the hand.

“It is important to draw attention to the complications from diabetes and how they can arise in order to discover them early, which enables faster treatment and thus a better outcome.

The newly published study strengthens the pattern of blood sugar being a crucial factor for an increased risk of being affected by trigger finger. Image is in the public domain

“In addition to nerve compressions and trigger finger, there may also be a link with thickening of the connective tissue in the palm (Dupuytren’s contracture), impairment of joint movement and the risk of arthritis at the base of the thumb. The mechanisms behind these complications probably differ in the case of diabetes.

“The results of this study are interesting, as we can show that blood sugar dysregulation has a connection with the development of trigger finger,” says Lars B. Dahlin, professor at Lund University and consultant in hand surgery at Skåne University Hospital. 

The next step in the research will be to chart how effective it is to operate on patients with diabetes who are affected by trigger finger. 

“From our experience at the clinic, surgery goes well and there are few complications, but it takes a little longer for patients with type 1 and type 2 diabetes to regain full movement and function. We want to investigate this hypothesis further. Another interesting idea is to see if trigger finger could be a warning signal for type 2 diabetes.

“It is far from all who are affected by trigger finger that have diabetes, but it would be interesting to see if by using modern registers we can discover those who are in the risk zone for developing diabetes,” concludes Mattias Rydberg.

About this diabetes research news

Author: Lotte Billing
Source: Lund University
Contact: Lotte Billing – Lund University
Image: The image is in the public domain

Original Research: Closed access.
“High HbA1c Levels Are Associated With Development of Trigger Finger in Type 1 and Type 2 Diabetes: An Observational Register-Based Study From Sweden” by Mattias Rydberg et al. Diabetes Care


Abstract

See also

High HbA1c Levels Are Associated With Development of Trigger Finger in Type 1 and Type 2 Diabetes: An Observational Register-Based Study From Sweden

OBJECTIVE

Trigger finger (TF) is a hand disorder causing the fingers to painfully lock in flexion. Diabetes is a known risk factor; however, whether strict glycemic control effectively lowers risk of TF is unknown. Our aim was to examine whether high HbA1c was associated with increased risk of TF among individuals with diabetes.

RESEARCH DESIGN AND METHODS

The Swedish National Diabetes Register (NDR) was cross-linked with the health care register of the Region of Skåne in southern Sweden. In total, 9,682 individuals with type 1 diabetes (T1D) and 85,755 individuals with type 2 diabetes (T2D) aged ≥18 years were included from 2004 to 2019. Associations between HbA1c and TF were calculated with sex-stratified, multivariate logistic regression models with 95% CIs, with adjustment for age, duration of diabetes, BMI, and systolic blood pressure.

RESULTS

In total, 486 women and 271 men with T1D and 1,143 women and 1,009 men with T2D were diagnosed with TF. Increased levels of HbA1c were associated with TF among individuals with T1D (women OR 1.26 [95% CI 1.1–1.4], P = 0.001, and men 1.4 [1.2–1.7], P < 0.001) and T2D (women 1.14 [95% CI 1.2–1.2], P < 0.001, and men 1.12 [95% CI 1.0–1.2], P = 0.003).

CONCLUSIONS

Hyperglycemia increases the risk of developing TF among individuals with T1D and T2D. Optimal treatment of diabetes seems to be of importance for prevention of diabetic hand complications such as TF.

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