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Vaccination to prevent dementia? New research suggests one way viral infections can accelerate neurodegeneration

One in nine Americans ages 65 and over had Alzheimer’s disease in 2022, and countless others were indirectly affected as caregivers, health care providers and taxpayers. There is currently no cure – available treatments primarily focus on prevention by encouraging protective factors, such as exercise and healthy diet, and reducing aggravating factors, such as diabetes and high blood pressure.

One of these aggravating factors is viral infections. Researchers have identified that certain viruses such as herpes simplex virus type 1 (HSV-1, which causes cold sores), varicella zoster virus (VZV, which causes chickenpox and shingles) and SARS-CoV-2 (which causes COVID-19) can lead to a higher risk of Alzheimer’s disease and dementia following infection.

Figuring out how and when these viruses contribute to disease could help scientists develop new therapies to prevent dementia. However, researchers have been unable to consistently detect suspect viruses in brains of people who died of Alzheimer’s. Because the Alzheimer’s disease process can start decades before symptoms, some researchers have proposed that viruses act early in a “hit-and-run” manner; they trigger a cascade of events that lead to dementia but have already taken off. In other words, by the time researchers analyze patient brains, any detectable viral components are gone and causation is difficult to establish.

We are a neurovirologist, neurologist and neuroscientist team interested in the role viruses play in neurodegenerative diseases. In our recently published research, we use new technology to search for the tire tracks of these viruses in Alzheimer’s patients. By focusing on the most vulnerable entry point to the brain, the nose, we discovered a genetic network that provides evidence of a robust viral response.

Focusing on the olfactory system

Many of the viruses implicated in dementia, including herpesviruses and the virus that causes COVID-19, enter the nose and interact with the olfactory system.

The olfactory system is constantly bombarded with odors, pollutants and pathogens. Particles inhaled through the nostrils bind to specific olfactory receptor cells in the tissue lining the nasal cavity. These receptors send messages to other cells in what’s called the olfactory bulb, which acts like a relay station that transmits these messages down the long nerves of the olfactory tract. These messages are then transferred to the area of the brain responsible for learning and memory, the hippocampus.

The hippocampus plays a critical role assigning contextual information to odors, such as danger from the foul smell of propane or comfort from the smell of lavender. This area of the brain is also dramatically damaged in Alzheimer’s disease, causing devastating learning and memory deficits. For as many as 85% to 90% of Alzheimer’s patients, loss of smell is an early sign of disease.

The mechanism leading to smell loss in Alzheimer’s disease is relatively unknown. Like muscles that atrophy from lack of use, sensory deprivation is thought to lead to atrophy of the brain regions that specialize in interpreting sensory information. Strong sensory input to these regions is critical to maintain general brain health.

Olfactory inflammation and Alzheimer’s disease

We hypothesize that viral infections throughout life are both contributors to and potential drug targets in Alzheimers’s disease. To test this idea, we used emerging, state-of-the-art technology to investigate the mRNA and protein networks of the olfactory system of Alzheimer’s disease patients.

The body uses mRNA, which is transcribed from DNA, to translate genetic material into proteins. The body uses specific mRNA sequences to produce a network of proteins that are used to fight against certain viruses. In some cases, the body continues to activate these pathways even after the the virus is cleared, leading to chronic inflammation and tissue damage. Identifying which mRNA sequences and protein networks are present can allow us to infer, to a degree, whether the body is or was responding to a viral pathogen at some point.

Previously, sequencing mRNA in tissue samples was difficult because the molecules degrade very quickly. However, new technology specifically addresses that issue by measuring small subsections of mRNA at a time instead of trying to reconstruct the whole mRNA sequence at once.

We leveraged this technology to sequence the mRNA of olfactory bulb and olfactory tract samples from six people with familial Alzheimer’s, an inherited form of the disease, and six people without Alzheimer’s. We focused on familial Alzheimer’s because there is less variability in disease than in the sporadic, or nonfamilial, form of the disease, which can result from a number of different individual and environmental factors.

This image shows neurons in a small cross section of a mouse’s olfactory bulb. (Credit: Jeremy McIntyre/University of Florida College of Medicine via National Institutes of Health, CC BY-NC)

In the familial Alzheimer’s samples, we found altered gene expression indicating signs of a past viral infection in the olfactory bulb, as well as inflammatory immune responses in the olfactory tract. We also found higher levels of proteins involved in demyelination in the olfactory tract of familial Alzheimer’s samples than in the controls. Myelin is a protective fatty layer around nerves that allows electrical impulses to move quickly and smoothly from one area of the brain to another. Damage to myelin stalls signal transduction, resulting in impaired neural communication and, by extension, neurodegeneration.

Based on these findings, we hypothesize that viral infections, and the resulting inflammation and demyelination within the olfactory system, may disrupt the function of the hippocampus by impairing communication from the olfactory bulb. This scenario could contribute to the accelerated neurodegeneration seen in Alzheimer’s disease.

Implications for patient health

Epidemiological data supports the role of viral infections in the development of Alzheimer’s disease. For example, the varicella zoster virus is linked to a nearly threefold risk of developing dementia within five years of infection for patients with a shingles rash on their face. A recent report also found a nearly 70% increased risk of getting diagnosed with Alzheimer’s within a year of a COVID-19 diagnosis for people over 65.

These studies suggest that vaccination may be a potential measure to prevent dementia. For example, vaccination against the seasonal flu virus and herpes zoster is associated with an up to 29% and 30% reduced risk of developing dementia, respectively.

Further research investigating how viral infections can trigger neurodegeneration could aid in the development of antiviral drugs and vaccines against the viruses implicated in Alzheimer’s disease.

Report written by Andrew Bubak, Assistant Research Professor of Neurology; Diego Restrepo, Professor of Cell and Developmental Biology; and Maria Nagel, Professor of Neurology and Ophthalmology, all from the University of Colorado Anschutz Medical Campus. This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Carlos Correa, Twins accelerate talks as deal with Mets remains in limbo

The possibility of a stunning reunion between Carlos Correa and the Twins is increasing, team sources said Monday night.

With the status of the mega-deal he agreed to with the New York Mets last month unresolved, the Twins suddenly are back in the mix for the free-agent shortstop. Two club sources said Monday that talks between the Twins and Correa have begun to accelerate. A separate major-league source confirmed the development as well.

Talks are fluid, and the Mets are not necessarily out of the bidding. But 19 days have passed since the Mets reached agreement with Correa on a 12-year, $315 million contract, pending a physical. The Mets, like the San Francisco Giants before them, grew concerned over the condition of Correa’s right ankle during their medical review. As the parties continue to negotiate contract language, Correa’s agent, Scott Boras, reached out to other teams, including the Twins. 

In November, Correa opted out of the three-year, $105.3 million contract he signed with the Twins in March 2022. Still, the club hadn’t been shy about wanting to retain Correa, who batted .291/.366/.467 with 22 home runs, 64 RBIs and produced 4.9 Wins Above Replacement last season. 


Carlos Correa being introduced by the Twins alongside president of baseball operations Derek Falvey in March 2022. (Brace Hemmelgarn / Getty Images)

Minnesota’s original efforts, which included a 10-year, $285 million offer, failed when Correa agreed to a 13-year, $350 million contract with the Giants on Dec. 14. A week after signing with San Francisco, the accord fell apart over a difference of opinions about Correa’s physical exam. The Mets’ deal quickly stalled for the same reason.

Despite those concerns, Boras and the Mets have tried to find a path to get the two-time All-Star shortstop to New York. Correa originally was so thrilled to hear the Mets signed him last month that he tackled Boras onto a hotel bed during a celebration. 

The Twins, however, have remained in constant contact with Boras, sources said, creating a potential landing spot if Correa’s deal with the Mets falls apart.

All along, the Twins expected Correa and the Mets to finalize their agreement, but Twins president of baseball operations Derek Falvey kept his club prepared just in case.

While sources said the Twins always knew a big-market club could “blow them out of the water” on a larger deal, the team made it clear it was very interested in bringing Correa back and was open to being creative with potential for opt outs and other protections in a deal. 

Last March, Boras lauded the Twins’ front office for its creativity when the two sides hammered out the original contract for Correa in a span of 14 hours. The Twins also gained experience putting together incentive-laden deals after completing a seven-year, $100 million extension for oft-injured center fielder Byron Buxton in December 2021, a contract that includes up to $10 million in annual performance bonuses based on staying on the field.

While the Twins would definitely want to conduct their own physical with Correa, the team already has a sense of his overall condition after conducting a thorough exam last March. 

Even though the Twins performed an exit exam on Correa in October, those are often limited to areas of concern that arose during a player’s regular-season visits to the trainer’s room. Aside from an incident in May when Correa thought he broke his finger, team sources indicated the shortstop never set foot in the trainer’s room, not even after he writhed in pain on the ground after a hard slide into second base in a Sept. 20 contest at Kansas City. 

After that game, Correa acknowledged he had a metal plate inserted in his right leg, the result of an injury that occurred when he was in the minor leagues in 2014.

“He just hit my plate,” Correa said, referring to the hardware in his leg. “I had surgery and he hit it. Just kind of felt numb. Vibrating. So I was just waiting for it to calm down. It was a little scary, but when I moved I knew I was good.”

Aside from the finger, which cost him 12 games, and a late-May bout with COVID-19, which resulted in eight games missed, Correa was quite durable for the Twins. He appeared in 136 of the remaining 142 games and was a fixture in the lineup for a Twins team that suffered injury after injury throughout the season. 

The Twins loved what Correa brought to them in their one season together, a mix of swagger and baseball savvy. And now, in yet another stunning turn, they are in position to bring the Correa saga full circle, back to Minnesota. 

(Top photo: Carmen Mandato / Getty Images)



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Common Arthritis Treatment May Actually Accelerate Disease Progression

Osteoarthritis is a degenerative joint disease that causes the cartilage in the joints to break down, leading to pain, stiffness, and difficulty moving. It is a common condition that often affects the hands, knees, hips, and spine. Risk factors for developing osteoarthritis include aging, obesity, and a history of joint injuries.

Two recent studies have shown that corticosteroid injections, which are commonly used to treat the pain associated with knee osteoarthritis, may actually contribute to the progression of the disease. These findings were recently presented at the annual meeting of the Radiological Society of North America (RSNA).

Osteoarthritis is a widespread condition that affects 32.5 million adults in the United States and is characterized by the degeneration and breakdown of cartilage in the joints. Knee osteoarthritis, which affects approximately 800,000 people each year, is a chronic and progressive condition that can cause pain and difficulty moving. Approximately 10% of individuals with knee osteoarthritis seek noninvasive treatments and turn to corticosteroid or hyaluronic

Researchers in both studies chose cohorts from the Osteoarthritis Initiative, a multicenter, longitudinal, observational study of nearly 5,000 participants with knee osteoarthritis currently in its 14th year of follow-up.

Knee joint of a patient showing (A) severe cartilage defects and (B) intact knee joint. Credit: RSNA and Upasana Upadhyay Bharadwaj, M.D.

In the first study, researchers at the University of California, San Francisco included 210 Osteoarthritis Initiative participants, 70 of whom received intraarticular injections, and a control group of 140 who did not receive injections during a two-year period. Of the 70 patients who received injections, 44 were injected with corticosteroids, and 26 were injected with hyaluronic acid. The treatment and control groups were matched by age, sex, body mass index, pain and physical activity scores, and severity of the disease.

MRI was performed on all patients at the time of the injection and two years before and after. The MRI scans were assessed using whole-organ magnetic resonance imaging score (WORMS), a grading system for knee osteoarthritis that focuses on the meniscus, bone marrow lesions, cartilage, joint effusion, and ligaments. The researchers identified osteoarthritis progression by comparing the imaging scores from the initial scans and two-year follow-up scans.

“This is the first direct comparison of corticosteroid and hyaluronic acid injections using the semi-quantitative, whole organ assessment of the knee with MRI,” said Upasana Upadhyay Bharadwaj, M.D., a research fellow in the Department of Radiology at University of California, San Francisco.

Statistical analysis showed that corticosteroid knee injections were significantly associated with the overall progression of osteoarthritis in the knee, specifically in the lateral meniscus, lateral cartilage, and medial cartilage.

Hyaluronic acid knee injections were not significantly associated with the progression of osteoarthritis in the knee. Compared to the control group, the group who received hyaluronic injections showed a decreased progression of osteoarthritis, specifically in bone marrow lesions.

“While both corticosteroid and hyaluronic acid injections are reported to help with symptomatic pain relief for knee osteoarthritis, our results conclusively show that corticosteroids are associated with significant progression of knee osteoarthritis up to two years post-injection and must be administered with caution,” Dr. Upadhyay Bharadwaj said.

“Hyaluronic acid, on the other hand, may slow down the progression of knee osteoarthritis and alleviate long-term effects while offering symptomatic relief.”

In the second study, researchers at the Chicago Medical School of Rosalind Franklin University of Medicine and Science conducted a case-control study comparing the radiographic progression of osteoarthritis in patients who received injections of corticosteroids and hyaluronic acid.

“While these injections provide some patients with short-term pain relief, the effects of the injections on the progression of the disease are unknown,” said researcher and medical student Azad Darbandi.

Darbandi’s team selected a cohort of 150 patients with similar baseline characteristics from the Osteoarthritis Initiative database, including 50 patients who received corticosteroid injections, 50 who received hyaluronic acid injections, and 50 who were not injected over a 36-month time period. The groups were matched by sex, body mass index, and X-ray findings.

Patients underwent X-ray imaging of the knee at baseline and two years later. The researchers analyzed the X-ray imaging, including joint space narrowing, formation of bone spurs, and bone thickening around the knee cartilage.

Compared to patients who received an injection of hyaluronic acid or no treatment at all, patients injected with corticosteroids had significantly more osteoarthritis progression, including medial joint space narrowing, a hallmark of the disease.

“Even though imaging findings for all patients were similar at baseline, the imaging hallmarks of osteoarthritis were worse two years later in patients who received corticosteroid injections compared to patients who received hyaluronic acid injections or no treatment at all,” Darbandi said.

“The results suggest that hyaluronic acid injections should be further explored for the management of knee osteoarthritis symptoms and that steroid injections should be utilized with more caution.”

“Knowing the long-term effects of these injections will help osteoarthritis patients and clinicians make more informed decisions for managing the disease and the pain it causes,” Dr. Upadhyay Bharadwaj added.

Meeting: 108th Scientific Assembly and Annual Meeting of the Radiological Society of North America

Dr. Upadhyay Bharadwaj’s co-authors are Thomas Link, M.D., Ph.D., Zehra Akkaya, Gabby Joseph, John Lynch, Ph.D., and Paula Giesler. Darbandi’s co-authors are Sean Hormozian, Atefe Pooyan, M.D., Ehsan Alipour, M.D., Firoozeh Shomal Zadeh, M.D., Parham Pezeshk, M.D., and Majid Chalian, M.D.



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Putin cites COVID response in push to accelerate Ukraine war efforts

Russian President Vladimir Putin on Tuesday addressed his new Government Coordination Council to hasten the country’s war efforts in Ukraine, alluding to the coronavirus pandemic as one reason to accelerate decisionmaking.

The Kremlin announced the council’s creation on Friday, saying it would improve coordination within Russia’s government as the country continues to face territorial losses in its invasion from a Ukrainian southern offensive.

“We faced certain difficulties and the need to upgrade our work, give it a new momentum and new character when we were responding to the coronavirus pandemic,” Putin told the group, according to remarks released by the Kremlin.

“We managed to do much then to update these regulations and get rid of the archaic procedures that are preventing us from moving forward at the pace the country needs,” he added.

Putin said the group, which is headed by Russian Prime Minister Mikhail Mishustin, includes deputy prime ministers, agency heads and regional representatives.

The body will look to more effectively provide medicine and equipment to support Russia’s invasion of Ukraine, which Moscow dubs a “special military operation,” although Putin did not explain in detail how these objectives would be accomplished.

“If we follow standard bureaucratic procedures and hide behind formalities, we will not achieve the desired result in any area,” he said. “We established a mechanism like the Coordination Council with the express purpose of resolving all issues faster and more effectively.”

Putin initially hoped to quickly force Ukraine’s surrender when Russia invaded the country in February, but Russian forces have seen a series of setbacks, first failing to take the capital city of Kyiv and now facing losses in territory captured in the spring.

Various U.S. and Western officials have indicated Russia has faced a variety of tactical and equipment failures during the invasion, and President Biden has said Putin “totally miscalculated.”

The efforts of Putin’s new coordinating group will look to counter gains made by a Ukrainian offensive previously focused in the country’s northeast that has now extended to the south.

As Russian forces retreat from an increasing number of settlements and towns, Putin has escalated the conflict by calling up to 300,000 reservists, threatening the use of nuclear weapons and annexing four Ukrainian regions.

Last week, Putin declared martial law in the four regions, which experts say could mean mass deportations of Ukrainians out of the Russian-occupied territory as Kyiv’s forces inch closer to Kherson, the sole regional capital controlled by Moscow.

Russia has also accused Ukraine of producing biological weapons and planning to use a radioactive “dirty bomb,” claims that have been condemned as Russian propaganda by U.S. officials.

Ukraine has cited those claims as evidence Russia itself is planning to stage a major attack in Ukraine, referencing purported evidence of planted mines at a dam and Putin’s past threats of nuclear warfare.

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Ford announces series of deals to accelerate EV push

Ford CEO Jim Farley attends the official launch of the all-new Ford F-150 Lightning electric pickup truck at the Ford Rouge Electric Vehicle Center in Dearborn, Michigan, U.S. April 26, 2022. REUTERS/Rebecca Cook/File Photo

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DETROIT, July 21 (Reuters) – Ford Motor Co (F.N) on Thursday announced a series of deals to accelerate its shift to electric vehicles, including sourcing battery capacity and raw materials from such companies as Chinese battery maker CATL (300750.SZ) and Australian mining giant Rio Tinto (RIO.AX).

The deals are part of Ford’s push to have its annual EV production rate globally reach 600,000 vehicles by late 2023 and more than 2 million by the end of 2026. Ford said it expects a compound annual growth rate for EVs to top 90% through 2026, more than doubling the forecast industry growth rate.

“We are putting the industrial system in place to scale quickly,” Ford Chief Executive Jim Farley said in a statement.

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In March, Ford boosted its planned spending on EVs through 2026 to $50 billion from its prior target of $30 billion, and reorganized its operations into separate units focused on EVs and gasoline-powered vehicles with Ford Model e and Ford Blue, respectively. read more

The Dearborn, Michigan-based company also said at the time that its EV business would not be profitable until the next-generation models begin production in 2025.

As part of its push to boost capacity, Ford said it is adding lithium iron phosphate (LFP) cell chemistry for EV batteries to its portfolio, alongside nickel cobalt manganese (NCM). Ford said it has secured all of the 60 gigawatt hours (GWh) of cell capacity needed to support the 600,000 run rate.

The U.S. automaker said CATL will provide full LFP battery packs for the Mustang Mach-E crossovers for North America starting next year as well as the F-150 Lightning pickups in early 2024.

The company is also working with LG Energy Solution and its long-time battery partner SK Innovation.(096770.KS)

Ford said it has now sourced about 70% of the battery cell capacity it needs to achieve its annual production rate of more than 2 million by late 2026.

To support the battery cell deals, Ford said it is direct sourcing battery cell raw materials as well, announcing deals to acquire most of the nickel needed through 2026 and beyond through agreements with Vale SA’s units in Canada and Indonesia, China’s Huayou Cobalt (603799.SS) and BHP .

It has also locked in lithium contracts through agreements with Rio Tinto, exploring a “significant” lithium off-take agreement from the mining company’s Rincon project in Argentina, Ford said. That is part of a multi-metal agreement that leverages Rio Tinto’s aluminum business and includes a potential opportunity on copper.

Ford announced other battery material deals. It signed a letter of intent with EcoPro BM and SK On to establish a cathode production plant in North America, an offtake agreement for ioneer Ltd (INR.AX) to supply lithium carbonate from Nevada beyond 2025, an agreement with Compass Minerals for lithium hydroxide and lithium carbonate from Utah, and an agreement for Syrah Resources(SYR.AX) and SK On for natural graphite from Louisiana.

The drive to the 600,000 EV run rate by late 2023 includes 270,000 Mustang Mach-E crossovers, 150,000 F-150 Lightning pickups, 150,000 Transit vans and 30,000 units of a new SUV for Europe whose production will significantly increase in 2024.

(This story corrects mention to Rio Tinto’s aluminum business, not Ford’s in paragraph 11)

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Reporting by Ben Klayman in Detroit; Editing by Bernadette Baum

Our Standards: The Thomson Reuters Trust Principles.

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How stress may accelerate aging of the immune system

Comment

As people age, their immune systems naturally begin to decline. This aging of the immune system, called immunosenescence, may be an important part of age-related health problems such as cancer and cardiovascular disease, as well as older people’s less effective response to vaccines.

But not all immune systems age at the same rate. In our recently published study, my colleagues and I found that social stress — the stress arising from difficult or challenging circumstances relating to your social position or relationships with other people — is associated with signs of accelerated immune system aging.

Data and immunosenescence

To better understand why people with the same chronological age can have different immunological ages, my colleagues and I looked at data from the Health and Retirement Study, a large, nationally representative survey of U.S. adults over age 50 funded by the National Institute on Aging.

How stress can damage your brain and body

HRS researchers ask participants about different kinds of stressors they have experienced, including stressful life events such as job loss; discrimination, which could mean being treated unfairly or being denied care; major lifetime trauma, such as a family member’s having a life-threatening illness; and chronic stress, such as financial strain.

Recently, HRS researchers have also started collecting blood from a sample of participants, counting the number of different types of immune cells present, including white blood cells. These cells play a central role in the immune responses to viruses, bacteria and other invaders. This is the first time such detailed information about immune cells has been collected in a large national survey.

By analyzing the data from 5,744 HRS participants who both provided blood and answered survey questions about stress, my research team and I found that people who experienced more stress had a lower proportion of “naive” T cells — fresh cells needed to take on invaders the immune system hasn’t encountered before.

4 ways that older people can bolster or improve their mental health

They also have a larger proportion of “late differentiated” T cells — older cells that have exhausted their ability to fight invaders and instead produce proteins that can increase harmful inflammation.

People with low proportions of newer T cells and high proportions of older T cells have a more aged immune system.

After we controlled for poor diet and low exercise, however, the connection between stress and accelerated immune aging wasn’t as strong. This suggests that improving these health behaviors might help offset the hazards associated with stress.

Similarly, after we accounted for potential exposure to cytomegalovirus (CMV) — a common, usually asymptomatic virus known to accelerate immune aging — the link between stress and immune cell aging was reduced. Though CMV normally stays dormant in the body, researchers have found that stress can cause CMV to flare up and force the immune system to commit more resources to control the reactivated virus. Sustained infection control can use up naive T cell supplies and result in more exhausted T cells that circulate throughout the body and cause chronic inflammation, an important contributor to age-related disease.

Understanding immune aging

Our study helps clarify the association between social stress and faster immune aging. It also highlights potential ways to slow down immune aging, such as changing how people cope with stress and improving lifestyle behaviors around diet, smoking and exercise. Developing effective cytomegalovirus vaccines may also help alleviate immune system aging.

Strengthening your immunity as you grow older

Epidemiological studies, however, cannot completely establish cause and effect. More research is needed to confirm whether stress reduction or lifestyle changes will lead to improvements in immune aging, and to better understand how stress and latent pathogens such as cytomegalovirus interact to cause illness and death. We are using additional data from the HRS to examine how these and other factors — including childhood adversity — affect immune aging over time.

Less aged immune systems are better able to fight infections and generate protective immunity from vaccines. Immunosenescence might help explain why people will probably have more severe cases of the coronavirus and a weaker response to vaccines as they age. Understanding what influences immune aging may help researchers better address age-related disparities in health and illness.

This article was originally published on theconversation.com.

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What Would Happen if Someone Moved at Twice The Speed of Light?

As far as we know, it’s not possible for a person to move at twice the speed of light. In fact, it’s not possible for any object with the kind of mass you or I have to move faster than the speed of light.

 

However, for certain strange particles, traveling at twice the speed of light might be possible – and it might send those particles back in time.

A universal speed limit

One of our best physical theories at the moment is the theory of relativity, developed by Albert Einstein. According to this theory, the speed of light operates as a universal speed limit on anything with mass.

Specifically, relativity tells us that nothing with mass can accelerate past the speed of light.

To accelerate an object with mass, we have to add energy. The faster we want the object to go, the more energy we’ll need.

The equations of relativity tell us that anything with mass – regardless of how much mass it has – would require an infinite amount of energy to be accelerated to the speed of light.

But all of the sources of energy we know of are finite: they are limited in some respect.

Indeed, it’s plausible the Universe only contains a finite amount of energy. That would mean there isn’t enough energy in the Universe to accelerate something with mass up to the speed of light.

Since you and I have mass, don’t expect to be traveling at twice the speed of light anytime soon.

 

Tachyons

This universal speed limit applies to anything with what we might call “ordinary mass”.

There are, however, hypothetical particles called tachyons with a special kind of mass called “imaginary mass”.

There is no evidence tachyons exist. But according to relativity, their possible existence can’t be ruled out.

If they do exist, tachyons must always be traveling faster than the speed of light. Just as something with ordinary mass can’t be accelerated past the speed of light, tachyons can’t be slowed down to below the speed of light.

Some physicists believe that if tachyons exist, they would constantly be traveling backwards in time. This is why tachyons are associated with time travel in many science fiction books and movies.

There are ideas that we might someday harness tachyons to build a time machine. But for now this remains a distant dream, as we don’t have the ability to detect potential tachyons.

Shortcuts?

It’s disappointing we can’t travel faster than the speed of light. The nearest star to us, other than the Sun, is 4.35 light-years away. So, traveling at the speed of light, it would take more than four years to get there.

The farthest star we’ve ever detected is 28 billion light-years away. So you can pretty much give up on charting the entire Universe.

 

That said, relativity does allow for the existence of “wormholes”.

A wormhole is a shortcut between any two points in space. While a star might be 4.5 light-years away in normal terms, it might only be a few hours away via a wormhole.

If there are any actual wormholes, they would let us travel great distances in a very short period of time – allowing us to get to the farthest reaches of the Universe within a single lifetime.

Unfortunately, like tachyons, wormholes remain entirely hypothetical.

Strange possibilities

Despite the fact we can’t genuinely travel faster than light, we can still try to imagine what it would be like to do so.

By thinking in this way, we are engaging in “counterfactual thinking”. We are considering what things would, or might, be like if reality was different in some way.

There are many different possibilities we could consider, each with a different set of physical principles.

So we can’t say with any certainty what would happen if we were able to travel faster than light. At best, we can guess what might happen. Would we start to travel back in time, as some scientists think tachyons might do?

I’ll leave it to you and your imagination to come up with some ideas!

Sam Baron, Associate professor, Australian Catholic University.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

 

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Lockdowns and supply chain disruption to accelerate Apple’s move away from China, with India a likely beneficiary, analysts say

Apple’s value chain in China, an emblem of the country’s global role as a source of labour and assembly, has been hit hard by strict lockdowns in Shanghai and neighbouring provinces, raising the risk that the US tech giant may accelerate a shift of its operations away from China, say analysts.

While it is hard to put an exact figure on the losses resulting from the disruption to transport and production along Apple’s extensive value chain in China, chief financial officer Luca Maestri told a conference call on Thursday that Covid-19-related lockdowns and a chip shortage would reduce the company’s revenue by up to US$8 billion in the June quarter.

Maestri said this was “substantially larger than” the impact in the previous quarter and also warned about the likely knock-on effect of reduced consumer demand in China due to lockdowns.

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Apple’s close links with China have, historically, been underpinned by two main factors. First, the country is an ideal assembly centre for the California-based tech giant, thanks to its advanced infrastructure, skilled labour force and efficient logistics services. Components from Taiwan, South Korea and elsewhere are assembled into iPhones and iPads on factory floors in China for the whole world to buy.

Secondly, China itself is the second-largest market for Apple, thanks to the country’s growing middle class, which has become increasingly affluent over the past decade, say analysts.

But this positive alignment of factors is now under threat.

China’s strict lockdowns in Shanghai and Jiangsu province – key financial and manufacturing centres – since the end of March to tame the highly-infectious Omicron variant of Covid-19, have raised doubts about the country’s position as an integral part of global supply chains for Apple.

The situation has become more acute for China given that other countries – particularly Vietnam and India, which are returning to normal after Covid-related disruption – are eyeing a bigger share of Apple’s value chain.

Apple CEO Tim Cook has maintained smooth relations with Beijing. Photo: EPA-EFE alt=Apple CEO Tim Cook has maintained smooth relations with Beijing. Photo: EPA-EFE>

According to calculations by the South China Morning Post, more than half of Apple’s 192 suppliers with an internal manufacturing site for the company, including Foxconn, Pegatron, Quanta, Wistron and Compal, have production facilities in lockdown-hit Shanghai and Jiangsu.

Moreover, two Foxconn factories in Shenzhen had to suspend operations for days in March amid a local brief lockdown, while the largest iPhone assembly compound in Zhengzhou has been short of labour as Covid-19 restrictions have made it hard for migrant workers from other areas to reach the Foxconn factory there.

For lesser-known suppliers or subcontractors in Apple’s value chain, it has been even harder to maintain normal levels of operation. Foxconn had to suspend operations at two plants in Kunshan last week after one worker in its closed-loop was found to be infected with Covid-19.

Ming-Chi Kuo, an analyst at TF Securities who follows Apple, said lockdowns in the Yangtze River Delta region would roughly lead to a 30 to 40 per cent drop in shipments this quarter for Apple, although the shortfall could be narrowed to 15 to 25 per cent if other suppliers step in.

Delivery times for Apple MacBook Pros have been delayed by up to five weeks as the sole assembler, Quanta, has been forced to suspend operations due to the Shanghai lockdown, said Kuo.

Apple had already started to consider reducing its reliance on China but the recent lockdowns have accelerated the process, said Kuo. Relocating some production facilities from China is “no longer a proposal but an action plan”, added Kuo.

Apple did not immediately respond to a request for comment on its plans for China in the face of lockdown-related disruption.

The Covid-19 lockdowns come at a time when geopolitical pressure is rising for an economic decoupling between China and the United States.

Former US President Donald Trump pushed for the reshoring of US manufacturing and the Biden administration has been working with regional allies to reduce supply chain reliance on China.

Two of the four campuses of Foxconn in Kunshan, located on the north of the city, went into strict lockdown on April 20 after the Apple supplier reported confirmed Covid cases. Photo: SCMP/Ann Cao alt=Two of the four campuses of Foxconn in Kunshan, located on the north of the city, went into strict lockdown on April 20 after the Apple supplier reported confirmed Covid cases. Photo: SCMP/Ann Cao>

Apple, under chief executive Tim Cook, has maintained a smooth relationship with Beijing despite some sporadic consumer boycotts of Apple products in China. Cook heads up the advisory committee for the economic management school at Tsinghua University, which gives him access to China’s national leaders.

Tech media outlet The Information reported at the end of last year that Cook signed an agreement with Chinese officials, estimated to be worth about US$275 billion, to help China develop its technological prowess and to head off state action which would have hobbled Apple’s devices and services in the country.

In Thursday’s conference call, Cook said Apple was likely to move more production capacity back to the US considering the ongoing challenges. “Our supply chain is truly global … we do a lot in the US and we’ll probably be doing even more here as more chips are produced here,” he said, without giving more details.

Other options for Apple could include India, where land and labour are much cheaper than in the United States. With roads and ports clogged in China due to lockdown, iPhone production in India surged by 50 per cent year-on-year in the first quarter of 2022. This was aided by a decision to assemble the iPhone 13 in a Foxconn factory near Chennai, according to Indian media reports.

And China remains critically important for Apple as a consumer market.

“China growth remains the fuel in the engine [for Apple],” Dan Ives and John Katsingris, analysts at New York-based Wedbush, wrote in a recent research report. But the analysts added that supply chain issues have already cut the sale of around 15 million units of iPhones over the past few quarters.

Meanwhile, there is little sign that China is about to give up on its “dynamic zero” policy approach to Covid-19. For those industrial enterprises allowed to resume production, strict quarantine rules remain in place, which could translate into additional costs, reduced efficiency and fresh uncertainties down the line.

“The best case [for full resumption] is June,” said Kuo.

This article originally appeared in the South China Morning Post (SCMP), the most authoritative voice reporting on China and Asia for more than a century. For more SCMP stories, please explore the SCMP app or visit the SCMP’s Facebook and Twitter pages. Copyright © 2022 South China Morning Post Publishers Ltd. All rights reserved.

Copyright (c) 2022. South China Morning Post Publishers Ltd. All rights reserved.



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Households squeezed as U.S. consumer prices accelerate; more pain coming

  • Consumer price index increases 0.8% in February
  • Gasoline accounts for nearly a third of rise in CPI
  • CPI jumps 7.9% year-on-year; costs of food, rent surge
  • Core CPI rises 0.5%; increases 6.4% year-on-year

WASHINGTON, March 10 (Reuters) – U.S. consumer prices surged in February, forcing Americans to dig deeper to pay for rent, food and gasoline, and inflation is poised to accelerate even further as Russia’s war against Ukraine drives up the costs of crude oil and other commodities.

The broad rise in prices reported by the Labor Department on Thursday led to the largest annual increase in inflation in 40 years. Inflation was already haunting the economy before Russia’s invasion of Ukraine on Feb. 24, and could further erode President Joe Biden’s popularity.

The Federal Reserve is expected to start raising interest rates next Wednesday. With inflation nearly four times the U.S. central bank’s 2% target, economists are expecting as many as seven rate hikes this year.

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Lower-income households bear the brunt of high inflation as they spend more of their income on food and gasoline.

“Consumers’ shock at rapidly rising gas prices at the pump will continue to put pressure on the Fed and policymakers to do something, anything, to slow down the speed at which prices everywhere are moving higher,” said Chris Zaccarelli, chief investment officer at Independent Advisor Alliance in Charlotte, North Carolina.

Reuters Graphics

The consumer price index increased 0.8% last month after gaining 0.6% in January. A 6.6% rebound in gasoline prices accounted for almost a third of the increase in the CPI. Gasoline prices had declined 0.8% in January. Food prices jumped 1.0%, with the cost of food consumed at home soaring 1.4%.

Prices for fruit and vegetables increased by the most since March 2010, while the rise in the cost of dairy and related products was the largest in nearly 11 years.

In the 12 months through February, the CPI shot up 7.9%, the biggest year-on-year increase since January 1982. That followed a 7.5% jump in January and was the fifth straight month of annual CPI readings north of 6%. February’s increase in the CPI was in line with economists’ expectations.

Last month’s CPI data does not fully capture the spike in oil prices following the outbreak of the war in Ukraine. Prices shot up more than 30%, with global benchmark Brent hitting a 2008 high at $139 a barrel, before retreating to trade around $112 a barrel on Thursday.

The United States and its allies have imposed harsh sanctions on Moscow, with Biden on Tuesday banning imports of Russian oil into the United States. Russia is the world’s second-largest crude oil exporter.

U.S. gasoline prices are averaging a record $4.318 per gallon compared with $3.469 a month ago, AAA data showed.

Biden on Thursday acknowledged the hardships Americans were facing from sky-rocketing prices, but blamed Russian President Vladimir Putin’s actions.

“As I have said from the start, there will be costs at home as we impose crippling sanctions in response to Putin’s unprovoked war, but Americans can know this, the costs we are imposing on Putin and his cronies are far more devastating than the costs we are facing,” Biden said in a statement.

Soaring inflation is wiping out wage gains. Inflation adjusted average hourly earnings fell 2.6% on a year-on-year basis in February, the Labor Department said. Moody’s Analytics estimates that inflation at February levels was costing the average household $296.45 per month, up from $276 in January.

Economists expect the annual CPI rate will peak above 8% in March or April and start to slow in the following months as the high readings from last spring drop out of the calculation.

Stocks on Wall Street were lower. The dollar (.DXY) gained versus a basket of currencies. U.S. Treasury yields rose.

Inflation

SOARING RENT COSTS

Inflation was ignited by a shift in spending to goods from services during the COVID-19 pandemic and trillions of dollars in relief from the government. The resulting surge in demand ran against capacity constraints as the spread of the coronavirus pushed millions of workers out of the labor market, making it harder to move raw materials to factories and finished goods to consumers.

Excluding the volatile food and energy components, the CPI increased 0.5% last month after advancing 0.6% in January.

A 0.5% rise in the cost of shelter like rental accommodation as well as hotel and motel rooms accounted for more than 40% of the increase in the so-called core CPI. The cost of rent jumped 0.6%, the most since March 2005. Rental costs are sticky and will keep core CPI hot.

“Due to the way rents are sampled in the CPI, resampling every six months, the index tends to lag other indicators such as the Zillow Observed Rent Index, suggesting CPI rents will likely continue to rise strongly for a while yet,” said Daniel Vernazza, chief international economist at UniCredit in London.

Consumers paid more for household furnishings and operations, motor vehicle insurance as well as clothing and personal care. Airline fares soared 5.2% as sharply declining coronavirus infections boosted demand for travel.

But prices of new motor vehicles rose modestly while used cars and trucks fell, suggesting some easing in pent-up demand. Motor vehicles were one of the main drivers of inflation because of a global semiconductor shortage.

In the 12 months through February, the core CPI vaulted 6.4%, the largest year-on-year gain since August 1982, after increasing 6.0% in January.

Despite high inflation, tighter monetary policy and the conflict in Ukraine, a recession is not expected. Demand for labor is strong, with a near record 11.3 million job openings at the end of January. Households are sitting on about $2.6 trillion in excess savings.

“The cost to consumers is high,” said Ryan Sweet, a senior economist at Moody’s Analytics in West Chester, Pennsylvania. “However, there are also reasons to be optimistic that consumers can weather a temporary spike in gasoline prices, as household balance sheets in aggregate are in great shape. Gasoline spending as a share of total nominal consumption is low.”

Though a separate report from the Labor Department showed initial claims for state unemployment benefits increased 11,000 to a seasonally adjusted 227,000 for the week ended March 5, they remained at levels consistent with a tight labor market.

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Reporting by Lucia Mutikani
Editing by Chizu Nomiyama and Paul Simao

Our Standards: The Thomson Reuters Trust Principles.

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Radical Idea Shows Laser Propulsion Could Rapidly Accelerate Trips to Mars

NASA and China plan to mount crewed missions to Mars in the next decade. While this represents a tremendous leap in terms of space exploration, it also presents significant logistical and technological challenges.

 

For starters, missions can only launch for Mars every 26 months when our two planets are at the closest points in their orbit to each other (during an “Opposition”). Using current technology, it would take six to nine months to transit from Earth to Mars.

Even with nuclear-thermal or nuclear-electric propulsion (NTP/NEP), a one-way transit could take 100 days to reach Mars.

However, a team of researchers from Montreal’s McGill University assessed the potential of a laser-thermal propulsion system. According to their study, a spacecraft that relies on a novel propulsion system – where lasers are used to heat hydrogen fuel – could reduce transit times to Mars to just 45 days!

Conceptual render of a Laser-Thermal-Propulsion System. (Duplay et al., 2022)

The research was led by Emmanuel Duplay, a McGill graduate and current MSc Aerospace Engineering student at TU Delft. He was joined by Associate Professor Andrew Higgins and multiple researchers with the Department of Mechanical Engineering at McGill University.

Their study, titled “Design of a rapid transit to Mars mission using laser-thermal propulsion”, was recently submitted to the journal Astronomy & Astronomy.

 

In recent years, directed-energy (DE) propulsion has been the subject of considerable research and interest. Examples include the Starlight program – also known as the Directed Energy Propulsion for Interstellar Exploration (DEEP-IN) and Directed Energy Interstellar Studies (DEIS) programs – developed by Prof. Phillip Lubin and the UCSB Experimental Cosmology Group (ECG).

As part of NASA-funded research that began in 2009, these programs aim to adapt large-scale DE applications for interstellar missions.

There’s also Breakthrough Starshot and Project Dragonfly, both of which emerged from a design study hosted by the Initiative for Interstellar Studies (i4iS) in 2013. These concepts call for a gigawatt-power laser array to accelerate a lightsail and a small spacecraft to a fraction of the speed of light (aka relativistic speeds) to reach nearby star systems in decades, rather than centuries or millennia.

But whereas these concepts are interstellar in focus, Duplay and his colleagues explored the possibility of an interplanetary concept.

As Duplay explained to Universe Today via email:

“The ultimate application of directed-energy propulsion would be to propel a lightsail to the stars for true interstellar travel, a possibility that motivated our team that did this study. We were interested in how the same laser technology could be used for rapid transit in the Solar System, which will hopefully be a nearer-term stepping stone that can demonstrate the technology.”

 

Aside from laser sail propulsion, DE is being explored for several other space exploration applications. This includes power beaming to and from spacecraft and permanently-shadowed habitats (e.g., the Artemis Program), communications, asteroid defense, and the search for possible technosignatures.

There’s also a concept for a laser-electric spacecraft being investigated by NASA and as part of a collaborative study between the UCSB ECG and MIT.

For this application, lasers are used to deliver power to photovoltaic arrays on a spacecraft, which is converted to electricity to power a Hall-Effect Thruster (ion engine). This idea is similar to a nuclear-electric propulsion (NEP) system, where a laser array takes the place of a nuclear reactor. As Duplay explained, their concept is related but different:

“Our approach is complimentary to these concepts, in that it uses the same phased-array laser concept, but would use a much more intense laser flux on the spacecraft to directly heat propellant, similar to a giant steam kettle. This permits the spacecraft to accelerate rapidly while it is still near Earth, so the laser does not need to focus as far into space.

“Our spacecraft is like a dragster that accelerates very quickly while still near Earth. We believe we can even use the same laser-powered rocket engine to bring the booster back into Earth orbit, after it has thrown the main vehicle to Mars, enabling it to be quickly recycled for the next launch.”

 

In this respect, the concept proposed by Duplay and his colleagues is akin to a nuclear-thermal propulsion (NTP) system, where the laser has taken the place of a nuclear reactor.

In addition to DE and hydrogen propellant, the mission architecture for a laser-thermal spacecraft includes several technologies from other architectures. As Duplay indicated, they include:

“[A]rrays of fiber-optic lasers that act as a single optical element, inflatable space structures that can be used to focus the laser beam when it arrives at the spacecraft into the heating chamber, and the development of high-temperature materials that allow the spacecraft to break against the Martian atmosphere upon arrival.”

This last element is essential given that there’s no laser array at Mars to decelerate the spacecraft once it reaches Mars.

“The inflatable reflector is a key from other directed-energy architectures: designed to be highly reflective, it can sustain a greater laser power per unit area than a photovoltaic panel, making this mission feasible with a modest laser array size compared to laser-electric propulsion,” added Duplay.

By combining these elements, a laser-thermal rocket could enable very fast transits to Mars that would be as short as six weeks – something that was considered possible only with nuclear-powered rocket engines before.

The most immediate benefit is that it presents a solution to the hazards of deep-space transits, like prolonged exposure to radiation and microgravity.

At the same time, says Duplay, the mission presents some hurdles since many of the technologies involved are bleeding-edge and have not been tested just yet:

“The laser heating chamber is likely the most significant challenge: Can we contain hydrogen gas, our propellant, as it is being heated by the laser beam to temperatures greater than 10,000 K while at the same time keeping walls of the chamber cool? Our models say this is feasible, but experimental testing at full scale is not possible at present because we have not yet built the 100 MW lasers needed.”

While much of the technology in this proposed mission architecture – and other similar proposals – is still in the theory and development phase, there is no doubt about their potential.

Reducing the time it takes to get to Mars to a matter of weeks instead of months will address two of the biggest challenges for Mars missions – logistical and health considerations.

Furthermore, establishing a rapid-transit system between Earth and Mars will speed the creation of infrastructure between Earth and Mars. This could include a Gateway-like space station in orbit of Mars, like the Mars Base Camp proposed by Lockheed Martin, as well as a laser array to decelerate incoming spacecraft.

The presence of these facilities would also accelerate plans to create a permanent human presence on the surface.

As Professor Higgins concluded:

“The Mars-in–45-days design study that Emmanuel led was motivated by exploring other, near-term applications of the phased array laser technology that Philip Lubin’s group is developing. The ability to deliver energy deep into space via laser would be a disruptive technology for propulsion and power. Our study examined the laser thermal approach, which looks encouraging, but the laser technology itself is the real game changer.”

This article was originally published by Universe Today. Read the original article.

 

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