Neanderthal DNA May Provide Clues About the Genetic Risks for Brain Disorders and Addiction

Summary: Traits with the strongest Neanderthal DNA contribution were sleep patterns, smoking habits, and alcohol consumption.

Source: Estonian Research Council

It has been known for a long time that human brain disorders such as neurological or psychiatric diseases run in families, suggesting some heritability. In line with this hypothesis, genetic risk factors for developing these illnesses have been identified.

However, fundamental questions about the evolutionary drivers have remained elusive. In other words, why are genetic variants that increase the risk for diseases not eliminated in the course of evolution?

To answer these questions has been notoriously difficult. However, new discoveries about events in the deep human past have handed scientists new tools to start to unravel these mysteries: when modern humans moved out of Africa >60,000 years ago, they met and mixed with other archaic humans such as Neandertals.

Around 40% of the Neandertal genome can still be found in present-day non-Africans, and each individual still carries ~2% of Neandertal DNA. Some of the archaic genetic variants may have conferred benefits at some point in our evolutionary past.

Today, scientists can use this information to learn more about the impact of these genetic variants on human behaviour and the risk of developing diseases.

Using this approach, a new study from an international team led by researchers from the University of Tartu, Charité Berlin and the Amsterdam UMC analysed Neandertal DNA associations with a large variety of more than a hundred brain disorders and traits such as sleep, smoking or alcohol use in the UK Biobank with the aim to narrow down the specific contribution of Neandertal DNA to variation in behavioural features in people today.

The study found that while Neandertal DNA showed over-proportional numbers of associations with several traits that are associated with central nervous system diseases, the diseases themselves did not show any significant numbers of Neandertal DNA associations.

Among the traits with the strongest Neandertal DNA contribution were smoking habits, alcohol consumption and sleeping patterns. Using data from other cohorts such as the Estonian Biobank, the Netherlands Study of Depression and Anxiety, FinnGen, Biobank Japan and deCode, several of these results could be replicated.

Of specific note were two independent top-risk Neandertal variants for a positive smoking status that were found in the UK Biobank and Biobank Japan respectively.

“Our results suggest that Neandertals carried multiple variants that substantially increase the smoking risk in people today. It remains unclear what phenotypic effects these variants had in Neandertals.

“However, these results provide interesting candidates for further functional testing and will potentially help us in the future to better understand Neandertal-specific biology,” said Michael Dannemann, associate professor of evolutionary genomics at the University of Tartu and the lead author of this study.

“The significant associations of Neandertal DNA with alcohol and smoking habits might help us to unravel the evolutionary origin of addictive and reward-seeking behaviour,” added Stefan M Gold, professor of neuropsychiatry at Charité, Berlin, who co-led this study.

Around 40% of the Neandertal genome can still be found in present-day non-Africans, and each individual still carries ~2% of Neandertal DNA. Image is in the public domain

“It is important to note that sleep problems, alcohol and nicotine use have consistently been identified as common risk factors for a range of neurological and psychiatric disorders. On the other hand, there are some intriguing findings from anthropology that have suggested some social benefits of higher tolerance to these substances in hunter-gatherers.

“Thus, our findings support the hypothesis that it is not brain diseases themselves that have evolutionary explanations but that natural selection shapes traits that make us vulnerable to them in the modern context.”

“Neandertals populated parts of Eurasia already more than 100,000 years before modern humans went out of Africa to populate the rest of the world. The high frequency of some of the variants that are associated with varying sleeping patterns might suggest that these have been advantageous outside of Africa – an environment that is defined, for example, by different levels of seasonality and UV light exposures than the environment that modern humans evolved in,” added Dannemann.

About this genetics and evolutionary neuroscience research news

Author: Carlos Kuiv
Source: Estonian Research Council
Contact: Carlos Kuiv – Estonian Research Council
Image: The image is in the public domain

See also

Original Research: Open access.
“Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes” by Michael Dannemann et al. Translational Psychiatry


Abstract

Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes

Despite advances in identifying the genetic basis of psychiatric and neurological disorders, fundamental questions about their evolutionary origins remain elusive.

Here, introgressed variants from archaic humans such as Neandertals can serve as an intriguing research paradigm.

We compared the number of associations for Neandertal variants to the number of associations of frequency-matched non-archaic variants with regard to human CNS disorders (neurological and psychiatric), nervous system drug prescriptions (as a proxy for disease), and related, non-disease phenotypes in the UK biobank (UKBB).

While no enrichment for Neandertal genetic variants were observed in the UKBB for psychiatric or neurological disease categories, we found significant associations with certain behavioral phenotypes including pain, chronotype/sleep, smoking and alcohol consumption.

In some instances, the enrichment signal was driven by Neandertal variants that represented the strongest association genome-wide. SNPs within a Neandertal haplotype that was associated with smoking in the UKBB could be replicated in four independent genomics datasets.

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Biden administration fears North Korea building up to a new nuclear test, but hampered by lack of intelligence



CNN
 — 

A lack of hard intelligence inside North Korea is curtailing the United States’ ability to determine Kim Jong Un’s intentions as the hermit kingdom fires a barrage of powerful missile launches, according to senior administration officials.

The recent tests have caused administration officials to grow concerned that Kim is set to oversee his nation’s seventh nuclear test.

So far, President Joe Biden has responded to the historic level of provocation by sending a US aircraft carrier to the region. The US and South Korea performed live-fire missile tests of their own and, in an urgently arranged telephone call with Japan’s prime minister, Biden vowed to coordinate on a “longer-term response” to the increasingly belligerent North.

White House officials have declined to detail any analysis or assessment that sheds light on why there has been a rapid increase in escalatory action, citing an inability to talk publicly about classified intelligence. But two senior US officials familiar with the matter acknowledged a central issue in divining the dictator’s motives is a lack of hard intelligence altogether.

“We have quite a good picture on the state of North Korean conventional and missile capabilities. What’s much harder is the intentions component, where, of course, collection is a bigger problem,” said Chris Johnstone, a senior adviser at the Center for Strategic and International Studies and a former director for East Asia on the National Security Council under Biden.

“Since so much of what North Korea does is driven by the leader himself, you really have to get inside his head, and that’s a hard intelligence problem.”

North Korea has long been isolated and largely shuttered from the rest of the world, a reality that has become even more acute in recent years due to the Covid-19 pandemic. The North lacks the widespread use of technology that not only facilitates economic and societal advances, but also provides critical windows and opportunities to glean information for the intelligence services of the US and its allies.

That leaves the White House without the type of information that could help predict when precisely a test may occur or allow for greater insights into Kim’s thinking as Biden works to calibrate an approach that avoids escalation.

“It’s difficult to know what is inside his mind and how he makes his decisions,” John Kirby, the strategic communications coordinator for the National Security Council, told CNN’s Christiane Amanpour. “Our ability to divine intelligence out of Pyongyang is fairly limited. So, it’s hard to know what’s prompting this. But what we do know is he’s continuing to try and improve his program, his capabilities.”

The intelligence community “knows a fair bit about his inner circle, a fair bit about how decisions are made,” Johnstone said. “But at the end of the day, it really is him. And when the circle is so small – and they don’t leave the country – it’s a pretty hard target.”

The latest missile launches mark the 24th time that North Korea has conducted missile tests this year, the highest annual tally since Kim took power in 2011.

Sanctions applied by the past three administration have done little to stop Kim’s march toward a viable nuclear weapon, even as they have left the country deeply isolated and many of its people impoverished. Diplomacy has similarly failed to yield much progress in halting a weapons program that North Korea says it will never abandon.

The Biden administration’s attempts to directly engage Pyongyang – delivered through a variety of channels, both direct and indirect – have been met with silence, according to officials. While the White House is confident its messages seeking diplomacy without preconditions “anytime, anyplace” have been received by Kim, he has yet to respond.

“We remain prepared to engage in serious and sustained diplomacy,” a US official said. “It is unfortunate that the DPRK has not responded to our outreach.”

Another underground nuclear test – potentially timed near November’s midterm elections – would amount to an attention-grabbing move that US officials have been bracing for over the past several months, beginning in the Spring when intelligence showed new activity at one of the country’s nuclear sites around the time of Biden’s first presidential visit to Asia.

White House aides said they were prepared to respond, including through adjustments to the US military posture in the region and the deployment of strategic assets. Yet the test didn’t come during Biden’s trip, underscoring the limits of US intelligence in predicting exactly when or why North Korea may test its advanced weapons.

“Anytime people start speculating on what North Korea might or might not do, they tend to have their expectations confounded one way or another,” national security adviser Jake Sullivan said at the time.

US officials and outside analysts anticipate the US isn’t likely to get much warning of a nuclear test. US military and intelligence agencies assess North Korea could be ready to resume underground nuclear testing at any moment, largely based on satellite imagery showing above-ground preparations at its Punggye-ri test site appear to be complete.

The country’s rainy season is now over, opening up the roads to the site. What’s not clear is whether North Korea has placed nuclear material in any of the underground tunnels at the site.

“The country is dried out the test site looks really well rebuilt to my eye. It’s really at this point probably a political choice for them,” said Jeffrey Lewis, a weapons expert and professor at the Middlebury Institute of International Studies. “I think when they are technically ready and politically ready, we’ve got all the warning we’re gonna get.”

Officials believe the missile and nuclear tests serve a practical purpose, beyond simply sending a message to the US and its allies in the region, which allow the North to further refine its systems as it works toward the ultimate goal of a nuclear-tipped missile that can reach the US mainland. Testing ever-more-powerful weapons also enhances Kim’s stature inside North Korea.

“What concerns us is whatever happens in these launches – how far they go and whether they succeed or fail – he learns. And he is able to improve his ballistic missile capabilities with every subsequent launch. So that’s of concern to us,” Kirby said.

Lewis cautioned against reading too much into individual ballistic missile tests. The primary motivation for North Korea, he said, is technical development – “especially the short-range ones where I think they’re no longer testing the missiles, they’re testing the crews.”

Other analysts believe the spate of missile tests is better understood as a response to Kim’s domestic woes.

“North Korea has had a very difficult period during Covid, essentially shutting off the country entirely, including to China. The food situation isn’t great,” Johnstone said. “The external enemy is part of what he uses to sustain his position.”

Still, determining precisely why North Korea is testing missiles at any particular moment has proved an enduring challenge for US administrations stretching back decades. For Biden and his top national security aides, deciphering North Korea’s intentions as it accelerates its weapons testing has proved difficult and administration officials are candid that previous efforts to assign motivation to Pyongyang’s actions have later been proved wrong.

“The North Koreans almost always have reasons for what they do. And our track record of understanding those ahead of time is not always so great,” one US official familiar with North Korea policy said.

Biden and his team have scoffed at the prospect of staging a high-profile meeting with Kim akin to the three summits former President Donald Trump convened with the dictator. Instead, they have said a meeting between the two leaders would come only after extensive preparatory diplomacy between officials on both sides and with an express purpose.

At the same time, Biden also rejected the “strategic patience” approach adopted by his onetime boss, former President Barack Obama, seeking instead a phased approach in which North Korea gives up parts of its program in exchange for sanctions relief.

Biden administration officials quietly acknowledge that their North Korea policy is not expected to trigger progress on the intractable nuclear challenge, administration sources said. But they also entered office expecting North Korea was not going to engage diplomatically quickly due to a tumultuous few years of back and forth with the US under Trump and the effect of Covid.

Some officials are now beginning to consider how the Biden administration could approach the distinct foreign policy challenge in the second half of Biden’s term, sources said, though neither the President nor his senior-most aides have indicated a desire to make the issue a top priority.

“Our position on diplomacy and dialogue has not changed,” said State Department deputy spokesperson Vedant Patel when asked if the Biden administration would consider re-evaluating their North Korea policy given the recent missile tests.

If there is one silver lining to Pyongyang’s recent provocations and the threat of a possible nuclear test, Johnstone said, it is that the common threat has helped the United States more smoothly navigate the historically contentious relationship between Japan and South Korea. And it could accelerate a debate in Japan about doubling its defense spending to 2% of its GDP, he said.

Asked what policy levers the Biden administration has at its disposal to try to curtail Pyongyang’s nuclear program, Lewis was succinct: “None.”

“When North Korea did not have nuclear weapons, there were interesting choices to be made about how to entice and or pressure them to not build some,” Lewis said. “Convincing North Korea to give up nuclear weapons that it already has is a totally different game.”

As the US has moved in what one official called “a clear and calibrated” way with its critical allies in the region over the course of the last several days, one central player remains largely unseen: China.

With US-China tensions reaching new heights over the last several months, substantive communications between key US officials and their Chinese counterparts have remained largely on ice, according to several senior US officials. Any Chinese absence as US officials grapple with Kim’s motives creates a particularly acute challenge given the country’s role as a central interlocutor between the US and its allies and North Korea.

Sullivan directly addressed the issue during a four-and-a-half hour meeting with China’s top diplomat Yang Jiechi in June, officials said. He pointed to North Korea as a primary area where the countries could cooperate, even amid the strained relations.

Sullivan “made very clear that we believe this is an area where the United States and China should be able to work together,” a senior administration official said.

But just this week China demonstrated a lack of desire to work with the US on curbing North Korea’s provocations. China’s representative at the UN cast the recent missile launches as a result of US aggressions in the region during a UN Security Council meeting.

White House officials believe the timing of a seventh nuclear test could also be dictated by political machinations inside China. Multiple officials noted they were closely watching the period immediately after the conclusion of the Communist Party’s congress later this month.

One official noted it was unlikely Kim would seek create a significant geopolitical crisis moment as Chinese President Xi Jinping moves toward his third term.

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William Byron wins NASCAR appeal, regains playoff points

CONCORD, N.C. — An appeals panel on Thursday reinstated the 25 points William Byron had been docked by NASCAR for deliberately spinning championship rival Denny Hamlin, a critical decision that helps his playoff hopes.

The three-person panel found that Byron did break a NASCAR rule for spinning Hamlin under caution. But Hendrick Motorsports had appealed the NASCAR penalty, which was initially a $50,000 fine and the loss of 25 critical points in the championship race.

The panel raised the fine to $100,000 but gave Byron back his points. The favorable ruling moved Byron out from below the elimination line heading into Sunday’s race at Charlotte Motor Speedway, where the playoff field will be cut from 12 to eight.

Byron was 10th in the standings with the loss of points; he’s now seventh in the standings and 14 points above the cut line.

The decision from the panel — television executive Hunter Nickell and short-track promoters Dale Pinilis and Kevin Whitaker — upended the standings heading into the second elimination race of the playoffs.

Austin Cindric and Chase Briscoe, who were tied for eighth, both dropped below the cut line. Christopher Bell dropped from 33 points below the cutline to 45 points out, and Daniel Suarez now sits in eighth in the standings.

The controversy surrounding Byron’s action at Texas Motor Speedway two weeks ago was because the NASCAR officials in the scoring tower missed the deliberate spin of Hamlin. It was done out of anger under caution; despite the lengthy caution period and massive replay screen in the Texas infield, NASCAR simply missed it and wasn’t able to issue an in-race penalty.

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Researchers discover star being consumed by its smaller, deader neighbor

The Sun might be a solitary star in our solar system, but around half of all other stars in the Milky Way are part of binary systems, in which two orbit each other. These can have incredibly fast orbital periods — scientists have found two white dwarfs that take just 5 minutes and 21 seconds to orbit each other. Another binary system is notable for a different reason: one star is feasting on the other.

Around 3,000 light years away, there’s a binary system that belongs to a class called “cataclysmic variables.” That’s an incredible term I’m going to use after my next failed cooking experiment, by the way. In space terms, when a star similar to our sun tightly orbits a , that’s a cataclysmic variable. As  notes, “variable” relates to the combined brightness of the two stars changing over time, at least in terms of how we view the system from terra firma. These luminosity levels can change significantly, which is where the “cataclysmic” part comes into play.

The two stars in the 8 billion-year-old system in question orbit each other every 51 minutes. That’s the shortest known orbital period for a cataclysmic variable system. The distance between the stars has narrowed over millions of years and they’re now closer to each other than we are to the Moon, researchers at Massachusetts Institute of Technology and elsewhere have determined. In a paper published in Nature this week, the researchers stated that the white dwarf is drawing material away from the Sun-like partner.

“It’s an old pair of stars, where one of the two moved on — when stars die of old age they become white dwarfs — but then this remnant began to eat its companion,” MIT astrophysicist and the paper’s lead author Kevin Burdge told Reuters. “Right before the second one could end its stellar life cycle and become a white dwarf in the way that stars normally do — by evolving into a type of star called a red giant — the leftover white dwarf remnant of the first star interrupted the end of the companion’s lifecycle and started slowly consuming it.”

The researchers found that the larger star has a similar temperature to the Sun, but has been reduced to around 10 percent of our celestial neighbor’s diameter. It’s now about the size of Jupiter. The white dwarf is far smaller, as it has a diameter around 1.5 times the size of Earth’s. However, it has a dense core, with a mass of around 56 percent that of our Sun’s.

The white dwarf has been munching away on hydrogen from the larger star’s outer layers, leaving the latter unusually rich in helium. The larger star is also morphing into a teardrop shape due to the gravitational pull of the white dwarf. That’s one reason for the changes in the binary system’s levels of brightness.

MIT notes that the system can emit “enormous, variable flashes of light” as a result of the hydrogen-sapping process. It added that, long ago, astronomers believed these flashes to be the consequence of an unknown cataclysm. While we have a clearer understanding of the situation these days, this is more evidence, as if it were needed, that space is cool and terrifying in equal measure.

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NYPD car crashed into eight pedestrians after being cut off

An NYPD officer struck eight pedestrians — including a child and her grandmother — in The Bronx Thursday afternoon while responding to an emergency call, cops said.

The marked patrol car was responding to a grand larceny in progress just after 3:15 p.m. when it jumped the curb near Hoe and Westchester avenues and hit the pedestrians before crashing into a pole, according to police and law-enforcement sources.

The marked patrol car was responding to a grand larceny in progress just after 3:15 p.m.
The car jumped the curb near Hoe and Westchester avenues.
Cops believe the patrol car was either cut off or struck by another vehicle.
The two officers in the vehicle were also injured but it’s not clear to what extent.
A police car hit eight people in The Bronx Thursday afternoon.
Three of the pedestrians were left in critical condition following the accident.

Three of the pedestrians were left in critical condition, cops said. It’s unclear if the girl and her grandmother were among those seriously injured and the conditions of the other five pedestrians were also not immediately clear.

All were expected to survive, police said. 

Cops believe the patrol car was either cut off or struck by another vehicle, forcing it off the road, the sources said.

The two officers in the vehicle were also injured but not seriously.

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A New Function of the Cerebellum

Summary: The cerebellum plays a key role in the storage of both positive and negative memories of emotional events.

Source: University of Basel

The cerebellum is known primarily for the regulation of movement. Researchers at the University of Basel have now discovered that the cerebellum also plays an important role in remembering emotional experiences.

The study appears in the journal PNAS.

Both positive and negative emotional experiences are stored particularly well in memory. This phenomenon is important to our survival, since we need to remember dangerous situations in order to avoid them in the future.

Previous studies have shown that a brain structure called the amygdala, which is important in the processing of emotions, plays a central role in this phenomenon.

Emotions activate the amygdala, which in turn facilitates the storage of information in various areas of the cerebrum.

The current research, led by Professor Dominique de Quervain and Professor Andreas Papassotiropoulos at the University of Basel, investigates the role of the cerebellum in storing emotional experiences. In a large-scale study, the researchers showed 1,418 participants emotional and neutral images and recorded the subjects’ brain activity using magnetic resonance imaging.

In a memory test conducted later, the positive and negative images were remembered by the participants much better than the neutral images. The improved storage of emotional images was linked with an increase in brain activity in the areas of the cerebrum already known to play a part.

However, the team also identified increased activity in the cerebellum.

The cerebellum in communication with the cerebrum

The researchers were also able to demonstrate that the cerebellum shows stronger communication with various areas of the cerebrum during the process of enhanced storage of the emotional images. It receives information from the cingulate gyrus – a region of the brain that is important in the perception and evaluation of feelings.

Furthermore, the cerebellum sends out signals to various regions of the brain, including the amygdala and hippocampus. The latter plays a central role in memory storage.

The cerebellum (activation in red) communicates with various areas of the cerebrum (activations in green) to enhance storage of emotional information. Credit: MCN, University of Basel

“These results indicate that the cerebellum is an integral component of a network that is responsible for the improved storage of emotional information,” says de Quervain.

Although an improved memory for emotional events is a crucial mechanism for survival, it does have its downsides: in the case of very negative experiences, it can lead to recurring anxiety.

This means that the findings, which have now been released, may also be relevant in understanding psychiatric conditions such as post-traumatic stress disorder.

Basel research on emotions and memory

The current study forms part of a large-scale research project conducted by the Research Platform Molecular and Cognitive Neurosciences (MCN) at the University of Basel and the University Psychiatric Clinics (UPK) Basel.

The aim of this project is to gain a better understanding of emotional and cognitive processes and to transfer results from basic research to clinical projects.

See also

About this neuroscience and memory research news

Author: Angelika Jacobs
Source: University of Basel
Contact: Angelika Jacobs – University of Basel
Image: The image is credited to MCN, University of Basel

Original Research: Open access.
“Human cerebellum and corticocerebellar connections involved in emotional memory enhancement” by Dominique de Quervain et al. PNAS


Abstract

Human cerebellum and corticocerebellar connections involved in emotional memory enhancement

Emotional information is better remembered than neutral information. Extensive evidence indicates that the amygdala and its interactions with other cerebral regions play an important role in the memory-enhancing effect of emotional arousal.

While the cerebellum has been found to be involved in fear conditioning, its role in emotional enhancement of episodic memory is less clear.

To address this issue, we used a whole-brain functional MRI approach in 1,418 healthy participants. First, we identified clusters significantly activated during enhanced memory encoding of negative and positive emotional pictures. In addition to the well-known emotional memory–related cerebral regions, we identified a cluster in the cerebellum.

We then used dynamic causal modeling and identified several cerebellar connections with increased connection strength corresponding to enhanced emotional memory, including one to a cluster covering the amygdala and hippocampus, and bidirectional connections with a cluster covering the anterior cingulate cortex.

The present findings indicate that the cerebellum is an integral part of a network involved in emotional enhancement of episodic memory.

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Webb, Hubble Team Up To Trace Interstellar Dust – “We Got More Than We Bargained For”

By combining data from NASA’s James Webb Space Telescope and NASA’s Hubble Space Telescope, researchers were able to trace light that was emitted by the large white elliptical galaxy at left through the spiral galaxy at right. As a result, they were able to identify the effects of interstellar dust in the spiral galaxy. Webb’s near-infrared data also show us the galaxy’s longer, extremely dusty spiral arms in far more detail, giving them an appearance of overlapping with the central bulge of the bright white elliptical galaxy on the left, though the pair are not interacting. In this image, green, yellow, and red were assigned to Webb’s near-infrared data taken in 0.9, 1.5, and 3.56 microns (F090W, F150W, and F356W respectively). Blue was assigned to two Hubble filters, ultraviolet data taken in 0.34 microns (F336W) and visible light in 0.61 microns (F606W).
Credit: Science: NASA, ESA, CSA, Rogier Windhorst (ASU), William Keel (University of Alabama), Stuart Wyithe (University of Melbourne), JWST PEARLS Team, Image Processing: Alyssa Pagan (STScI)

“We got more than we bargained for by combining data from

VV 191 is the latest addition to a small number of galaxies that helps researchers directly compare the properties of galactic dust. This target was selected from nearly 2,000 superimposed galaxy pairs identified by Galaxy Zoo citizen science volunteers.

Because dust changes the brightness and colors that appear in images of the galaxies, it is important to understand where dust is present in them. Since dust grains are partially responsible for the formation of new stars and planets, astronomers are always striving to identify their presence for further investigations.

Researchers identified a previously unknown lensed galaxy for the first time in new near-infrared data from NASA’s James Webb Space Telescope. Above the white elliptical galaxy at left, a faint red arc appears in the inset at 10 o’clock. This is a very distant galaxy whose appearance is warped. Its light is bent by the gravity of the elliptical foreground galaxy. Plus, its appearance is duplicated. The stretched red arc is warped where it reappears – as a dot – at 4 o’clock. In this image, green, yellow, and red were assigned to Webb’s near-infrared data taken in 0.9, 1.5, and 3.56 microns (F090W, F150W, and F356W respectively). Blue was assigned to two Hubble filters, ultraviolet data taken in 0.34 microns (F336W) and visible light in 0.61 microns (F606W).
Credit: Science: NASA, ESA, CSA, Rogier Windhorst (ASU), William Keel (University of Alabama), Stuart Wyithe JWST PEARLS Team, Image Processing: Alyssa Pagan (STScI)

The image also holds a second discovery that’s easier to overlook. Carefully examine the white elliptical galaxy at left. A faint red arc appears in the inset at 10 o’clock. This arc is a very distant galaxy whose light is bent by the gravity of the elliptical foreground galaxy – and its appearance is duplicated. The stretched red arc is warped where it reappears – as a dot – at 4 o’clock. Because these images of the lensed galaxy are so faint and so red that they went unrecognized in Hubble data. However, they are unmistakable in Webb’s near-infrared image. Simulations of gravitationally lensed galaxies like this help astronomers reconstruct how much mass is in individual stars, as well as how much dark matter is in the core of this galaxy.

As with many images from the James Webb Space Telescope, this image of VV 191 shows additional galaxies deeper and deeper in the background. Two patchy spirals to the upper left of the elliptical galaxy have similar apparent sizes, but show up in very different colors. One is likely very dusty and the other very far away, but astronomers will need to obtain data known as spectra to determine which is which.

References:

“Webb’s PEARLS: dust attenuation and gravitational lensing in the backlit-galaxy system VV 191” by William C. Keel, Rogier A. Windhorst, Rolf A. Jansen, Seth H. Cohen, Benne Holwerda, Sarah T. Bradford, Clayton D. Robertson, Giovanni Ferrami, Stuart Wyithe, Haojing Yan, Christopher J. Conselice, Simon P. Driver, Norman A. Grogin, Christopher N.A. Willmer, Anton M. Koekemoer, Brenda L. Frye, Nimish P. Hathi, Russell E. Ryan Jr., Nor Pirzkal, Madeline A. Marshall, Dan Coe, Jose M. Diego, Thomas J. Broadhurst, Michael J. Rutkowski, Lifan Wang, S.P. Willner, Andreea Petric, Cheng Cheng and Adi Zitrin, 30 August 2022, Astrophysics > Astrophysics of Galaxies.
arXiv:2208.14475

“Webb’s PEARLS: Prime Extragalactic Areas for Reionization and Lensing Science: Project Overview and First Results” by Rogier A. Windhorst, Seth H. Cohen, Rolf A. Jansen, Jake Summers, Scott Tompkins, Christopher J. Conselice, Simon P. Driver, Haojing Yan, Dan Coe, Brenda Frye, Norman Grogin, Anton Koekemoer, Madeline A. Marshall, Nor Pirzkal, Aaron Robotham, Russell E. Ryan Jr., Christopher N. A. Willmer, Timothy Carleton, Jose M. Diego, William C. Keel, Rosalia O’Brien, Paolo Porto, Caleb Redshaw, Sydney Scheller, Andi Swirbul, Stephen M. Wilkins, S. P. Willner, Adi Zitrin, Nathan J. Adams, Duncan Austin, Richard G. Arendt, John F. Beacom, Rachana A. Bhatawdekar, Larry D. Bradley, Thomas J. Broadhurst, Cheng Cheng, Francesca Civano, Liang Dai, Herve Dole, Jordan C. J. D’Silva, Kenneth J. Duncan, Giovanni G. Fazio, Giovanni Ferrami, Leonardo Ferreira, Steven L. Finkelstein, Lukas J. Furtak, Alex Griffiths, Heidi B. Hammel, Kevin C. Harrington, Nimish P. Hathi, Benne W. Holwerda, Jia-Sheng Huang, Minhee Hyun, Myungshin Im, Bhavin A. Joshi, Patrick S. Kamieneski, Patrick Kelly, Rebecca L. Larson, Juno Li, Jeremy Lim, Zhiyuan Ma, Peter Maksym, Giorgio Manzoni, Ashish Kumar Meena, Stefanie N. Milam, Mario Nonino, Massimo Pascale, Justin D. R. Pierel, Andreea Petric, Maria del Carmen Polletta, Huub J. A. Rottgering, Michael J. Rutkowski, Ian Smail, Amber N. Straughn, Louis-Gregory Strolger, James A. A. Trussler, Lifan Wang, Brian Welch, J. Stuart B. Wyithe, Min Yun, Erik Zackrisson, Jiashuo Zhang and Xiurui Zhao, 9 September 2022, Astrophysics > Cosmology and Nongalactic Astrophysics.
arXiv:2209.04119

Webb interdisciplinary scientist Rogier Windhorst of Arizona State University and his team obtained the data used in this image from early results of the Prime Extragalactic Areas for Reionization and Lensing Science (PEARLS) JWST Guaranteed Time Observation (GTO) programs, GTO 1176 and 2738. Additional data from Hubble’s STARSMOG snapshot program (SNAP 13695) and GO 15106, were added. Jake Summers, also of Arizona State, performed the pipeline data reduction. The dust analysis was led by William Keel of the University of Alabama, while the Hubble data acquisition was led by Benne Holwerda of the University of Louisville in Kentucky. The detailed gravitational-lensing analysis was conducted by Giovanni Ferrami and Stuart Wyithe, both of the University of Melbourne, Australia and ASTRO 3D, Australia.



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Twitter, Elon Musk Talks Continue, Focus on Financing, Litigation

Representatives of

Twitter Inc.

TWTR -3.72%

and

Elon Musk

continued Thursday to work to hammer out an agreement that would allow the billionaire’s purchase of the social-media company to proceed, with the parties racing to seal a pact by Monday, a person familiar with the matter said.

Mr. Musk effectively kicked off the negotiations earlier this week with his surprise proposal to close the deal at its original price after seeking for months to get out of it.

The negotiations, which follow an earlier effort to negotiate a lower price, are focused on ensuring that Mr. Musk’s debt financing will remain in place and on conditions to stay litigation over the deal until it closes, as The Wall Street Journal reported Wednesday. Mr. Musk is now requesting that the deal be contingent on his receipt of the necessary debt financing.

The lawyers are trying to reach an agreement that would pause a trial planned for Oct. 17 in the next few days, the person said. That would avert a deposition from Mr. Musk, which after being postponed is now scheduled for Monday.

The idea is to put the litigation on hold until the deal closes, at which point it would be dropped. That could take days or a few weeks.

Meanwhile, Mr. Musk’s team in a Thursday filing asked the court to stay the lawsuit. It said in the filing that the financing banks are working to fund the deal so it can close, which it expects to happen on or around Oct. 28. His team argues that proceeding with the litigation, as it says Twitter prefers, could keep the deal in limbo longer.

The two sides remain in active dialogue and things could change quickly, the person cautioned.

Mr. Musk agreed to buy Twitter in April for $54.20 a share, or $44 billion. He later moved to get out of the deal, claiming among other things that Twitter had misrepresented the number of bots on its platform. Twitter sued him over the summer and he countersued.

Renewed uncertainty about the deal has weighed on Twitter shares, which closed down 3.7% at $49.39 Thursday. They had shot up above $52 earlier in the week after Mr. Musk signaled a willingness to close the deal after all.

Write to Cara Lombardo at cara.lombardo@wsj.com

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Swedish probe finds signs of ‘detonations’ at Nord Stream leak sites

A Swedish investigation of leaks in two Russian natural gas pipelines that run under the Baltic Sea to Europe found evidence that “detonations” caused extensive damage, strengthening suspicions of “serious sabotage.”

Sweden’s Security Service said ​Thursday ​that it had seized evidence ​​​of what caused the ruptures in Nord Stream 1 and 2 ​last week but did not provide details. 

Authorities had noted when the leaks in the pipelines off of Sweden and Denmark were first disclosed that explosions were recorded in the area.

Denmark and Sweden have suspected that explosives were used to sabotage the pipelines that carry natural gas to Germany after high levels of methane were detected.

At the time of the ruptures, the pipelines were not carrying gas, but some residue remained in the lines. 

Swedish Foreign Minister Ann Linde (left), Swedish Prime Minister Magdalena Andersson and Swedish Defense Minister Peter Hultqvist hold a press conference about the gas leak in the Baltic Sea from Nord Stream.
Fredrik Persson/AP
An image from an intelligence report depicting a release of gas emanating from a leak on the Nord Stream 1 gas pipeline.
ImageSat International (ISI)/AFP via Getty Images

The ​incident​ ignited a new round of tension between Washington and Moscow over Vladimir Putin’s war in Ukraine.​

Russia accused the US of sabotaging the lines, saying Washington and its allies had the most to gain from restricting energy supplies to Europe, claims the West denies.

Europe, which had received up to 40% of its gas from Russia before the Ukraine invasion in February, is facing an energy crisis this winter after Moscow cut off its supply. 

Gas bubbles from the Nord Stream 2 leak reaching surface of the Baltic Sea.
Danish Defence Command/REUTERS

The investigation into the leaks by the Swedish Coast Guard and Navy would have involved unmanned vehicles, Swedish Navy spokesman Jimmie Adamsson said, because the pipes are in water about 230 feet deep.

With Post wires

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Lionel Messi says 2022 World Cup with Argentina will be his last

The 2022 World Cup in Qatar next month will be the last of Lionel Messi’s storied career.

The 35-year-old Argentina star, who will play in his fifth World Cup, is still seeking his first title at the showpiece tournament (which begins on Nov. 20 this year) and admitted he feels nervous ahead of his last appearance on world football’s biggest stage.

“There’s some anxiety and nerves at the same time. It is the last one,” Messi said in an interview with Star Plus.

It is the first time the Paris Saint-Germain striker has spoken openly about his future after the tournament, with Messi having not said definitively whether he would retire from the national team after Qatar.

Argentina, who are unbeaten in their past 35 competitive matches, will arrive at the World Cup with their confidence high after winning the 2021 Copa America final against hosts Brazil, which Messi believes was a turning point for his team after several near misses.

“In a World Cup, anything can happen. All the matches are very tough. The favourites don’t always end up winning,” Messi said. “I don’t know if we’re the favourites, but Argentina is always a candidate because of its history. Now even more so because of the moment we’re in, but we are not the favourites. I think there are other teams that are above us.”

Argentina won the World Cup in 1978 and 1986. The team will open the tournament on Nov. 22 against Saudi Arabia in Group C before facing Mexico and Poland.

Messi’s record with Argentina stands in stark contrast to his success at club level. Argentina came close to ending their long trophy drought on three occasions but were beaten by Germany in the 2014 World Cup final and by Chile in the 2015 and 2016 Copa America finals.

“I have been playing with the national team for a long time now,” Messi said. “There have been spectacular moments, like in 2014, 2015 and 2016, but we didn’t win and were criticised for not being champions.

“We did everything right until the finals.”

Messi said he was heading to Qatar with a positive outlook as the elder statesman in a team full of young talent.

“It’s been very hard, but in 2019 a new group with many young people came and won the Copa America. That helped us a lot,” he added.

Argentina face the United Arab Emirates in their final warm-up in November before beginning group play in Qatar.

Information from Reuters and The Associated Press was used in this story.

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