Category Archives: Health

Avoid emergency rooms unless situation is life-threatening as COVID overwhelms system

Michigan health officials are urging residents to avoid the emergency department at hospitals, outside of a life-threatening situation, to help alleviate pressure on health care systems as COVID continues to surge.

Michigan COVID-19-related hospitalizations are currently at an all-time high. Hospital leaders have been asking residents to take extra precaution against COVID spread as capacity dwindles at many local hospitals, including Beaumont and Henry Ford.

Related: 6 takeaways: Henry Ford Health officials say Michigan’s current COVID ‘crisis’ worse than a year ago

Ad

Michigan’s health care systems continue to be overburdened with COVID-19 patients, a majority of which are unvaccinated. From Jan. 15 – Dec. 3, 85.1% of COVID-19 cases, 88.1% of hospitalizations and 85.5% of deaths were among individuals who were not fully vaccinated, according to MDHHS data. Hospitalizations for COVID-19 continue to be mostly preventable by receiving one of the safe and effective COVID-19 vaccines.

“We all need to do our part to get vaccinated and boosted to keep ourselves, our families and our neighbors safe,” said Dr. Natasha Bagdasarian, MDHHS chief medical executive. “In addition to getting vaccinated, it is important to maintain your routine medical care so that any potential illness gets detected early and can be much more manageable. We urge Michiganders to continue seeking medical care but avoid emergency departments unless they have a life-threatening condition. If you don’t have a primary care provider, now is a great time to find one through contact with your local health care system.”

Ad

Illnesses can be treated at a variety of care settings depending on the severity of symptoms. Michiganders with life-threatening emergencies should always seek care by calling 911 or visiting the nearest emergency department.

Related: CDC endorses schools’ coronavirus ‘test-to-stay’ policies

Call a health care provider (like your local physician’s office) for a virtual or in-person appointment or visit an urgent care provider for ailments such as:

  • Cold or flu

  • Sprains

  • Rashes or minor burns

  • Ear pain

  • Animal or insect bites

  • Allergies

  • A COVID-19 test.

Call 911 or visit an emergency department for:

  • Life-threatening medical conditions or emergencies such as a heart attack or stroke

  • Choking

  • Head injuries

  • Severe burns

  • Severe chest pain or pressure

  • Broken bones

  • Uncontrolled bleeding

  • Severe respiratory distress.

If you have minor symptoms like sniffles or a cough you should get tested for COVID-19. To receive a flu or COVID-19 vaccine, visit a pharmacy or immunization clinic or VaccineFinder.org to find a location near you.

Ad

Choose the right kind of care graphic. (MDHHS)

Copyright 2021 by WDIV ClickOnDetroit – All rights reserved.

Read original article here

Dr. Anthony Fauci on flying, holiday parties as Covid omicron spikes

White House chief medical advisor Dr. Anthony Fauci said holiday parties with vaccinated family and friends are fairly low risk even as the Covid-19 omicron variant spreads throughout the U.S. and causes “a lot of breakthrough infections.”

“If you are vaccinated, your family is vaccinated, you have friends who are vaccinated — and hopefully also boosted — you can still enjoy a social gathering generally in a home,” Fauci said in an interview Friday on CNBC’s “Squawk Box.”

Covid hospitalizations have jumped by about 20% over the past two weeks, averaging about 68,400 over the last seven days, according to U.S. Department of Health and Human Services data. At the peak of the delta wave in September, more than 100,000 Covid patients were in the hospital.

‘The risk is never zero’

While delta remains the dominant variant in the U.S., omicron cases are projected to double every couple of days or so. On Tuesday, the Centers for Disease Control and Prevention said omicron made up about 3% of cases sequenced in the U.S. The Covid positivity rate in New York City doubled from 3.9% on Dec. 9 to 7.8% on Dec. 12, officials there reported Thursday.

Daily Covid cases rose 27% since before Thanksgiving to a seven-day average of 122,000, according to a CNBC analysis of data compiled by Johns Hopkins University. Cases remain below recent peak levels when the country was reporting an average of more than 170,000 daily cases in September.

“You’ve got to be careful when you go into large, public indoor spaces where there are a lot of people there,” Fauci said. “That’s the reason why you should be wearing a mask under those circumstances.”

Fauci said that if Covid cases keep rising, people “may need to be more restrictive” with their holiday plans. “But for right now, people who are vaccinated and boosted should feel reasonably comfortable.”

“The risk is never zero. That’s for sure, under any circumstances,” he said.

Is it safe to fly?

Despite rising omicron cases, Fauci said he would be comfortable flying, with precautions, if it was necessary.

“If I had to I would have no problem getting on an airplane. I’m vaccinated. I’m boosted. I know we have to wear a mask on an airplane,” he said, noting that he doesn’t currently plan to fly anywhere, since work keeps him in Washington.

Fauci said that masks on planes and in indoor settings such as airports work. “There’s no doubt that fabric masks work,” he said. “The N95 is the best one. But they are relatively uncomfortable to wear. Not a lot of people wear them. But a regular surgical mask as well as a cloth mask is fine.”

The best way to protect against getting Covid is to be vaccinated and boosted, Fauci added.

— CNBC’s Nate Rattner contributed to this report.

Read original article here

Could mRNA vaccines be the next frontier of cancer treatment?

When Omar Rodriguez finishes chemotherapy in February, he will return to the hospital for a dose of an mRNA vaccine. But it won’t be for Covid-19.

Rodriguez, 47, of Edinburg, Texas, was diagnosed with stage 3 colon cancer this summer. He has already had surgery to remove the tumor, but even after chemotherapy, his doctor told him there’s still a 70 percent chance his cancer will return in the next five years.

Rodriguez will be among the first people in the U.S. to receive a novel, personalized vaccine that harnesses the same mRNA technology used in Pfizer-BioNTech’s and Moderna’s Covid vaccines. This time, the vaccine won’t teach the body to target the coronavirus, but cancer cells, instead. 

The vaccine is being made by BioNTech, the German pharmaceutical company that partnered with Pfizer last year to produce the first Covid vaccine to be authorized for emergency use in the U.S. The company is studying the experimental vaccine in a phase 2 clinical trial; Rodriguez is one of the participants.

Patient samples arrive at BioNTech’s manufacturing facility in Mainz, Germany.BioNTech

BioNTech had its sights set on an mRNA vaccine long before the coronavirus swept the globe last year. The company was founded 13 years ago with the goal of developing cancer therapies, said its CEO, Dr. Uğur Şahin. 

The German company isn’t alone: Scientists around the world had been working to develop mRNA vaccines for decades before the coronavirus pandemic pushed the technology into the mainstream. The seemingly endless possibilities include treating or curing chronic diseases, including HIV and cancer. 

Strands of mRNA, or messenger RNA, are tiny snippets of genetic code that tell the body how to build proteins, essential building blocks of every cell in the body. 

The idea behind an mRNA vaccine — whether for Covid or for cancer — is to use the genetic material to train the immune system to target a specific protein. For the coronavirus, it’s the spike protein on the surface of the virus. For cancer, it could be a protein on the surface of a tumor cell. Once the immune system learns to recognize the protein, it can create antibodies or T cells that fight and destroy it, along with the cells that carry it.

A researcher prepares a fine tissue section from a patient’s tumor sample to investigate the tumor’s molecule makeup.BioNTech

“Messenger RNA is a unique chemical entity,” said Yizhou Dong, an associate professor of pharmaceutics and pharmacology at Ohio State University. Dong is not involved with the BioNTech vaccine. “It’s a very simple code that you can apply to any protein or peptide of interest, so it can be very versatile.”

Covid has pushed mRNA technology forward an incredible amount, said Anna Blakney, an assistant professor of biomedical engineering at the University of British Columbia who specializes in mRNA biotechnology. 

“We now know it’s both advantageous and safe,” said Blakney, who also isn’t involved with the BioNTech research. “I don’t think it’s immediately going to solve all these problems, but I do think there are areas that can really take the technology to the next level, and that’s really promising.”

Fighting cancer relapse

BioNTech chose to target colorectal cancer for a potential vaccine because of the disease’s relatively high rate of relapse. 

Colorectal cancer has been on the rise among people younger than 65 for the past decade, according to the Centers for Disease Control and Prevention. And a study led by the American Cancer Society estimated that people born in 1990 have double the risk of developing colorectal cancer in their lifetimes compared to people born around 1950, when risk was at its lowest.

With current treatments, about 30 percent to 40 percent of patients diagnosed with colorectal cancer will have a relapse about two or three years after surgery that’s caused by stray cancer cells that have moved elsewhere in the body, Şahin said.

“The question is if we add a vaccine, can we prevent these relapses?” Şahin said. “We believe the vaccine could be in a position to do that.”

A researcher looks at stained tissue from a patient’s tumor sample.BioNTech

The novel vaccine uses proteins unique to people’s tumors to train their immune systems to recognize cancer cells and then fight and hopefully kill the cells.  

“Instead of using more traditional chemotherapy, it’s now trying to get the body’s own immune system to fight the cancer,” said Dr. Scott Kopetz, a professor of gastrointestinal medical oncology at the University of Texas MD Anderson Cancer Center, who is leading the phase 2 clinical trial of the vaccine in the U.S. 

Additional trials are enrolling patients in Belgium, Germany and Spain, for a total of 200 people. 

To join the trial, patients must have tiny fragments of cancer DNA in their blood, even after they have undergone surgery or chemotherapy, said Dr. Liane Preußner, the vice president of clinical research at BioNTech. Detecting the cancer fragments in the blood is referred to as a liquid biopsy.

“Even though they are tumor-free on CT scans after the surgery, they probably have a very tiny amount of the tumor remaining in the body, making them at risk of an early disease recurrence,” Preußner said, adding that the goal is to intervene early with a targeted mRNA vaccine that could kill the remaining cells early on and prevent recurrences.

A new frontier of personalized medicine

When Rodriguez, the cancer patient from Texas, finishes his course of chemo early next year, doctors will do a liquid biopsy to check for circulating tumor DNA. 

If they find it, cancer cells from his tumor will be shipped off to BioNTech’s factory in Mainz, Germany. There, cancer cells from people like Rodriguez are analyzed for mutations specific to the patients and encoded in mRNA strands that go into tailor-made vaccines. 

The vaccine can target up to 20 mutations, and the whole process, from tumor biopsy to shot, takes around six weeks, Preußner said. “We need to screen the tumor, looking for the mutations. Then it takes a couple of days to manufacture the vaccine, to do the quality control, and then of course to ship it back to the hospital.”

A major advantage of mRNA therapies is the breakneck speed at which tailored treatments can be designed and produced. 

“It really only takes days to design a new mRNA vaccine,” Blakney said. “As long as you know the protein you need to code, you just type that into software and order that DNA.” 

Those enrolled in the four-year clinical trial will receive one infusion of the vaccine a week for six weeks to mount immune responses. After that, they will switch to a biweekly schedule and then every couple of weeks for about a year. 

The process, which isn’t unique to colon cancer, holds the potential for a wide range of recurrent cancers. A phase 2 clinical trial run by BioNTech partner Genentech is investigating a tailored mRNA for patients with melanoma. 

“It’s a very promising field, and we’re still at the beginning of the possibilities,” said Dong of Ohio State University. “There will only be more as we continue to better understand cancer biology.”

Follow NBC HEALTH on Twitter & Facebook



Read original article here

Marked Uptick in Crown Heights

Crown Heights Hatzalah has issued an important coronavirus update for the Crown Heights neighborhood: This week, there was a sudden and marked uptick of COVID cases in the neighborhood, 20x more contagious than previous strains; the potential for a rapid and widespread outbreak exists. Full Story

13 Teves, 5782
December 17, 2021

Dear Friends,

Yesterday, Thursday Yud-Beis Teves, there was a sudden and marked uptick of COVID cases in the neighborhood. This, after weeks and months of relative quiet. Although not yet proven, all
indicators would suggest that this is due to the new Omicron strain.

What we know about the Omicron strain from South African data as it unfolds, is the following

1)It is much more contagious (20x) than previous strains.

2)Those who were infected with the original strain, or the Delta strain, are only minimally protected, and reinfection is very common.

3)People who have taken 2 doses of the vaccine, more than 6 months ago, are less likely to be infected. However, the protection afforded is certainly not adequate, and appears less than 50% effective at this time. Booster doses of vaccine do increase protection considerably.

4)The monoclonal antibody infusions, that have been used so effectively to lessen the illness, do not appear to be very useful against the Omicron strain.

5)The good news is that although still potentially very dangerous, the illness associated with the Omicron strain appears less severe, with fewer deaths and hospitalizations B”H.

With all the above in mind, and very few precautions in place currently within the community, the potential for a rapid and widespread outbreak exists locally.

We urge all those who may be vulnerable in any way, particularly the elderly, and those with underlying health conditions, as well as the general public, to take the above information to
heart, and protect themselves, using all of the mitigation strategies well known to everyone.

A good and healthy Shabbos,
Crown Heights Hatzalah

Read original article here

S.Africa says vaccines, prior infection help mildness of COVID cases

  • S.Africa reported record daily infections this week
  • Fourth wave driven by Omicron variant
  • Slight pick-up in COVID-19 related deaths
  • Deaths mainly in unvaccinated, not fully vaccinated

JOHANNESBURG, Dec 17 (Reuters) – South Africa’s health minister said on Friday that the government believed that vaccines and high levels of prior COVID-19 infection were helping to keep disease milder in a wave driven by the Omicron variant.

There have been early anecdotal accounts suggesting that Omicron is causing less severe illness than previous variants in South Africa but scientists say it is too early to draw firm conclusions. read more

The country reported a record number of daily infections earlier this week. read more

Register now for FREE unlimited access to Reuters.com

Register

“We believe that it might not necessarily just be that Omicron is less virulent, but … coverage of vaccination (and) … natural immunity of people who have already had contact with the virus is also adding to the protection,” Health Minister Joe Phaahla told a news conference. “That’s why we are seeing mild illness.”

South Africa has given 44% of its adult population at least one dose of COVID-19 vaccine, more than many African countries but well short of the government’s year-end target. But among the over-50s vaccination coverage levels are over 60%.

Addressing the same news conference, Michelle Groome from the National Institute for Communicable Diseases (NICD) said there had been an uptick in COVID-19 hospital admissions and deaths.

A pharmacist prepares a dose of the coronavirus disease (COVID-19) Pfizer vaccine amidst the spread of the SARS-CoV-2 variant Omicron in Johannesburg, South Africa, December 04, 2021. REUTERS/Sumaya Hisham

Read More

“Starting to see a slight increase in deaths nationally, but once again this level is very much lower even than the baseline period we were seeing between the second and third waves,” said Groome, who heads the NICD’s division of public health, surveillance and response.

Waasila Jassat, a public health specialist at the NICD, estimated that of the COVID-19 related deaths that had happened in hospitals since mid-November more than half of the people who had died had co-morbidities, or tended to be old, and “a fair proportion of them were admitted for other reasons and died from other causes”.

She said that vaccination data on those who had died were incomplete but it seemed from self-reported information that 93% of the deaths were among either unvaccinated or not fully vaccinated individuals. She added that a further 3.5% of those who had died had been vaccinated more than five or six months ago.

Phaahla said early indications were that infections might have peaked in the most populated Gauteng province, where cases initially surged.

He added that in the coming week the health department would report back to the National Coronavirus Command Council on whether COVID-19 restrictions should be adjusted.

President Cyril Ramaphosa, who tested positive for COVID-19 on Sunday, is making good progress with his recovery from COVID-19 while continuing to receive treatment for mild symptoms, the presidency said on Friday.

Ramaphosa was given Johnson & Johnson’s (JNJ.N) one-dose vaccine in February. read more

Register now for FREE unlimited access to Reuters.com

Register

Reporting by Alexander Winning; Editing by Christopher Cushing and Giles Elgood

Our Standards: The Thomson Reuters Trust Principles.

Read original article here

We asked scientists what the omicron variant is going to do to the United States

If you want to get a good sense of how the omicron variant of COVID-19 is going to spread in the United States, just look across the ocean. In the United Kingdom and South Africa — two nations in which the omicron variant is quickly becoming more dominant than delta, or has already — infection rates are surging, largely because the variant is so much more transmissible. While current evidence suggests patients stricken with omicron are less likely to require hospitalization or die, huge infection rates have put massive pressure on both nations’ infrastructure. 

Now that omicron has graced the shores of the United States, we appear to be in the early phases of what the aforementioned countries are experiencing now. In New York City, the percentage of people testing positive for COVID-19 doubled in three days this week, with a Mayor Bill de Blasio advisor attributing the spike to the omicron variant. During a Tuesday briefing for the Centers for Disease Control and Prevention (CDC), top federal health officials told reporters that there had been a sevenfold jump in the prevalence of the omicron variant over the course of a single week.

Although the surge could subside after the spring, they added that if current trends persist there may also be a public health crisis. This would be especially so if the delta variant continues to wreak havoc, and an influenza epidemic exacerbates the problem caused by the pair of COVID-19 strains. The former scenario is already occurring and the latter is increasingly plausible, at least based on the timetable that scientists have established for when the omicron variant is likely to surge in the United States.

“Based on data from South Africa and Europe we can expect a significant increase in case numbers here in the US in the next several weeks,” Dr. Stephen Goldstein, professor at the Eccles Institute of Human Genetics at the University of Utah, told Salon by email. “It is possible to likely that peak cases numbers will exceed last winter’s peak.”

Dr. Georges Benjamin, executive director of the American Public Health Association, predicted that omicron will become the dominant variant in the United States within three to six months.

“This is based on its high degree of infectiousness, the significant number of people unvaccinated and the degree of breakthrough infections for people that are fully vaccinated but un-boosted,” Benjamin explained in writing. “Breakthrough infections in people that are fully vaccinated and boosted do occur, but are at a lower rate.”

The underlying problem is that the omicron variant is more transmissible than any previously. When it comes to stopping a pandemic, there are few things that epidemiologists dread more than a hyper-transmissible bug.

Indeed, Dr. Russell Medford, chairman of the Center for Global Health Innovation and Global Health Crisis Coordination Center, told Salon by email that he expects the omicron variant to dominate in the United States, just as it currently does in the United Kingdom, because “the omicron variant is significantly more transmissible than delta.” 

Dr. Monica Gandhi, infectious disease doctor and professor of medicine at the University of California–San Francisco, also said that the omicron variant is “more transmissible and will cause a wave of new infections,” but added that “there is now evidence that Omicron is less severe than previous strains.” What scientists do not yet know, she added, is “if this is because of increasing cellular immunity in the population in December 2021 versus an inherent property of the strain that makes it less virulent.”


Want more health and science stories in your inbox? Subscribe to Salon’s weekly newsletter The Vulgar Scientist.


Beyond transmissibility, the next-biggest concern with omicron is the question of vaccine resistance. In the past six months, the delta variant’s spread was blunted by the number of vaccinated Americans — and while delta was faintly vaccine-resistant, the majority of COVID-19 hospitalizations and deaths in the United States were among the unvaccinated, prompting the head of the CDC to dub the situation a “pandemic of the unvaccinated.” 

Yet omicron may be even more vaccine-resistant than delta, mainly for reasons relating to mutations on the spike protein. B.1.1.529 (the omicron variant’s official name) has 30 mutations located near the spike protein — which is worryingly mainly because the mRNA vaccines produced for COVID-19 specifically target that protein. The spike protein comprises the spikes that jut out from around the SARS-CoV-2 virus’ central sphere like spines on a sea urchin. The virus uses those spikes to enter a body’s cells, like a pick being used to open a lock, while existing vaccines help one’s cells produce proteins like those on the spikes that the immune system produces antibodies against. If the mutations sufficiently alter the spike protein, the body’s immune system may be less adept at recognizing the virus, having been prepared to fight a different version of the spike. 

“The two vaccinations, typically of any of the vaccines, offer virtually no protection against infection and transmission,” Dr. William Haseltine, founder and former CEO of Human Genome Sciences and currently the chair and president of the global health think tank Access Health International, told Salon. “Three vaccinations offer only very temporary protection after three months.”

William Haseltine, founder and former CEO of Human Genome Sciences and currently the chair and president of the global health think tank Access Health International, noted that the vaccines were adept at reducing hospitalization and death, perhaps even by as much as tenfold, but “will not eliminate it.” And, he added, the vaccines “will not spare those who are infected from you who are not similar protected from the consequences of the disease, which can be quite serious.” That’s because the vaccine is defensive, Haseltine said: it does not stop the virus from entering the body, only fights it once it is inside. 


Want more health and science stories in your inbox? Subscribe to Salon’s weekly newsletter The Vulgar Scientist.


Goldstein drew attention to a different caveat to the undeniable advantages of pre-existing immunity (whether through vaccination or infection).

“While encouraging on an individual basis, this coming surge will almost certainly produce enough severe infections to overwhelm already stretched healthcare resources,” Goldstein pointed out. “Double vaccination or prior infection, though they likely blunt severity, will not provide substantial protection from infection and onward transmission of omicron. It is imperative that people get vaccinated and/or boosted as soon as possible to protect themselves from the imminent omicron surge.”

Medford seemed more cautiously optimistic in his assessment. After writing to Salon that it seems clear the omicron variant has “considerable more resistant than delta to the neutralizing antibodies generated by our first line mRNA vaccines, and even more so with other vaccine types,” he added that “fortunately, a third dose of the mRNA vaccine, or booster, appears to largely corrects this vaccine resistance.” He said he thinks it is likely that the mRNA vaccines remain effective, ” especially with a third dose booster,” when it comes to preventing hospitalizations and deaths from serious omicron variant infections, although he added this has not been formally documented.

When it comes to the long-term consequences of the omicron variant in terms of the COVID-19 pandemic, two of the experts who spoke with Salon used the same word — “endemic.”

“The pandemic is transiting into a phase where it is endemic,” Benjamin told Salon. “This means there will episodic outbreaks that will be managed by contact racing, individual quarantines, targeted closures of activities or events and vaccinations /revaccinations for people that need it. Eventually as the disease becomes less severe/lethal some of these pubic health measures may be relaxed.”

Medford had a similar observation.

“COVID-19 variants such as omicron and others in the future will become an endemic feature of this disease akin to seasonal influenza,” Medford explained. “The data today with current vaccines are promising in that full vaccination (3 doses) are remain effective even in the face of new and structurally different viral variants.”

If COVID-19 truly is going to be endemic, then perhaps policymakers will need to take that into account. Looking forward, Gandhi (who did not use the word “endemic” in her email) suggested that it might be wise for public health officials to base their policies off of hospitalizations rather than infections, given that the omicron variant could lead to a surge of mild cases.

“We are likely to get many cases with omicron worldwide but – since the severity of disease is reduced — the impact of this variant (and restrictions such as mask mandates and capacity limits) should be based on hospitalization metrics for COVID-19,” Gandhi pointed out. “If the omicron variant is that transmissible but causes less severe disease, it is likely to find unvaccinated individuals, leading to more immunity in those populations, and infect even vaccinated individuals, boosting their immunity even further — which will hasten more immunity and hopefully make the pandemic calm own worldwide.”



Read original article here

What can the world learn from countries where Omicron is surging?

In South Africa, meanwhile, researchers say early data suggests Omicron causes milder symptoms — but it’s still unclear how much of a role immunity from vaccination or previous infection plays.

Denmark is mulling new restrictions in an attempt to control a spike of new cases.

It’s too late to keep Omicron out

Despite many nations imposing a slew of travel restrictions, the variant has spread quickly around the globe.

World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus told a news briefing Tuesday that 77 countries have now reported cases of Omicron, and “the reality is that Omicron is probably in most countries, even if it hasn’t been detected yet.”

“Omicron is spreading at a rate we have not seen with any previous variant,” Tedros said. “We’re concerned that people are dismissing Omicron as mild. Surely, we have learned by now that we underestimate this virus at our peril.”

He added that even if Omicron does cause milder disease, “the sheer number of cases could once again overwhelm unprepared health systems.”

The UK government removed 11 countries, all in southern Africa, from its “red list” on Tuesday in light of the spread of the Omicron variant within its own borders, meaning hotel quarantine is no longer required for visitors from those destinations.

The variant has already been detected in 36 US states, Washington DC and Puerto Rico.

“I imagine Omicron will be everywhere soon,” Michael Head, a senior research fellow in global health at England’s University of Southampton, told CNN. “And there’ll be a lot of Omicron around that most countries haven’t detected yet, in part because testing systems and genomic capacities may be limited.”

It may not take long for Omicron to become the dominant strain

The first two cases of the Omicron variant were detected in the UK on November 27. By Tuesday, it had overtaken Delta as the dominant Covid-19 strain in London, according to the UK Health Security Agency.

“Now, more than ever, getting your first, second dose or booster as soon as possible is vital. Please don’t leave it to chance,” London’s regional director for public health Kevin Fenton tweeted.

UK Health Secretary Sajid Javid said Tuesday that Omicron cases were doubling around every two days in the country, adding that “the growth in Omicron cases here in the UK is now mirroring the rapid increase that we are seeing in South Africa.”

By Thursday, the UK had reported 88,376 new coronavirus cases, according to government data — the highest daily number since the pandemic began. South Africa also recorded its highest ever number of daily cases Wednesday.

Denmark’s Statens Serum Institute (SSI) said Omicron was expected to become the dominant coronavirus variant this week. Almost 10,000 cases of infection were confirmed in the country in the last 24 hours, the SSI said Thursday.

Danish Prime Minister Mette Fredricksen said that cases were “very, very high” and that she had “no doubt that new measures will be needed to break the chains of infection.”

Meanwhile, the head of the EU Commission, Ursula von der Leyen, told lawmakers in Brussels that the Omicron coronavirus variant was set to become the dominant variant in the 27-nation bloc by mid-January.

In its latest risk assessment, published Wednesday, the European Centre for Disease Prevention and Control (ECDC) warned that there was a “very high” risk that the variant would spread further in the region, adding that it “is considered very likely to cause additional hospitalizations and fatalities,” beyond those already forecast from the Delta variant.

In the United States, National Institute of Allergy and Infectious Diseases Director Dr. Anthony Fauci told CNN Tuesday that Omicron would become the dominant coronavirus variant in the country “for sure” given its doubling time.

But, Fauci said, it’s not yet clear what that will mean for levels of severe disease.

On its website, the US Centers for Disease Control and Prevention now estimates that Omicron makes up 2.9% of circulating virus, versus Delta’s 96.8%, as of the week ending December 11.

Too early to know if Omicron infection is milder

Data from South Africa is being scrutinized for clues as to how Omicron’s spread could play out elsewhere.

South Africa’s National Institute for Communicable Diseases (NICD) has struck a cautiously optimistic tone. “Although the data are still being gathered, the evidence suggests that the current wave may be milder,” the agency said.

A study released Tuesday by Discovery Health — a large health insurance company in South Africa covering 3.7 million people — found that vaccines provide less protection against the new strain, but gave indications that Omicron causes milder symptoms than previous variants.

Two doses of the Pfizer vaccine were 33% protective against infection overall but 70% effective in preventing severe complications, including hospitalization, the researchers said.

Meanwhile, the risk of ending up in the hospital from Covid-19 was 29% lower for Omicron infections in adults, compared with the original strain, the study estimated.

But others are less confident. England’s Chief Medical Officer Chris Whitty warned that UK daily Covid-19 case records “will be broken a lot over the next few weeks as the rates continue to go up,” and that this will translate into “big numbers” needing hospital treatment in the coming weeks.

“I want to be clear: I’m afraid this is going to be a problem,” Whitty said Wednesday. “(The) exact proportions of it, of course, South African scientists and UK scientists and scientists globally are trying to determine at the moment.”

More real-time data is urgently needed before scientists can start to evaluate the severity of Omicron infection in other populations, Head said.

In the UK, scientists will be looking at the impact of the variant on a population where 89% of the population aged 12 and over has received at least one dose of a Covid-19 vaccine, and 44% of those aged 12 and over have had two doses and a booster, according to government figures. But the picture is very different elsewhere.

“In a lot of countries around the world there will be people who are unvaccinated or with one dose; across sub-Saharan Africa most people have not yet had two doses,” Head said. “So we need to look a little bit about whether there’s any protection, some protection … in those populations too.”

In South Africa, it’s possible that people already have some immunity to the virus — either through vaccination, previous infection or both — and that’s protecting them, according to Richard Friedland, CEO of the private hospital network Netcare. Multiple studies have shown that people who are naturally infected and then vaccinated have very strong immunity. South Africa’s population is also generally younger.

Vaccinations alone won’t slow Omicron

Health experts recommend that as Omicron spreads, countries continue to deploy the non-pharmaceutical interventions (NPIs) that are already known to reduce transmission of airborne viruses, such as social distancing and improved ventilation indoors.

“Countries can and must prevent the spread of Omicron with measures that work today,” said Tedros, the WHO chief. “It’s not vaccines instead of masks. It’s not vaccines instead of distancing. It’s not vaccines instead of ventilation or hand hygiene. Do it all. Do it consistently. Do it well.”

Faced with what Prime Minister Boris Johnson described as an incoming “tidal wave” of Omicron infections, the UK government decided to “turbocharge” its campaign to administer booster jabs.

Johnson’s office cited data suggesting that “vaccine efficacy against symptomatic infection is substantially reduced against Omicron with just two doses, but a third dose boosts protection back up to over 70%.”

However, the UK Parliament also approved the introduction of Covid passes, that show proof of vaccination or a recent negative Covid test, for entry to nightclubs and large venues, despite a major rebellion within Johnson’s own party. Lawmakers also passed measures including mandatory mask-wearing in most indoor spaces.
South Africa’s Minister of Health Joe Phaahla called Thursday for “responsible behavior and stronger compliance” with Covid-19 restrictions to prevent a possible surge of cases linked to the holiday season, a ministry news release said.

Head said it was important to continue mitigation measures while ensuring that populations around the world, including poorer nations, get access to three doses of Covid-19 vaccines as fast as possible — which could still take another 12 to 24 months, he cautioned.

Demand for vaccines and testing may rise

The rise of the Omicron variant may encourage more people to get a booster — and cause a spike in demand for Covid-19 tests.

As the UK threw open its booster program this week to all eligible adults, the NHS (National Health Service) website crashed due to demand for booster appointments, lateral flow test kits were no longer available online and long lines formed at vaccination walk-in centers. The UK Health Security Agency said Wednesday it was doubling the number of home testing kits it was sending out.

Denmark’s SSI also reported Tuesday that the country’s Covid-19 testing system was under pressure as infection rates rise.

Demand for vaccines in South Africa has not jumped since Omicron emerged. But South African President Cyril Ramaphosa, who tested positive for Covid-19 on Sunday, has urged his fellow citizens to get the shot. “Do everything you can and need to, to stay safe, beginning with vaccination,” he tweeted. Ramaphosa has been forced to delay his booster shot, his office said.

Despite surging cases, we may not see more lockdowns

There has been little talk of new lockdowns so far, despite concern over the rapid spread of Omicron.

Speaking during a visit to a vaccination center in Ramsgate, southern England, the UK Prime Minister said that rather than “locking stuff down,” the government is asking people to “be cautious” and “think about their activities in the run-up to Christmas.”

Johnson, who has faced a scandal over alleged Downing Street office parties in breach of restrictions last winter, added: “This is very different from last year because what we have is the additional protection of the vaccines and the ability to test.”

“I think scientifically at the minute there is a very strong argument for more interventions in place, but politically that’s less acceptable,” said Head.

However, countries “should be realistic that they may need lockdowns at some point,” he said — whether with this variant or a future one — as a lockdown “is a useful tool of last resort.”

Countries are still drawing on a range of other measures to try to curb the spread of the Omicron and Delta variants. For example, Norway brought in a ban on the serving of alcohol in restaurants and bars this week, in addition to imposing more restrictions in schools and speeding up its vaccination campaign.

But there also appears to be some degree of acceptance that people will have to learn to “live with” the new variant, especially where Covid-19 vaccination rates are high.

In Australia’s New South Wales state — where 93.3% of people aged 16 and over have been fully vaccinated — restrictions are being eased this week despite Omicron cases being detected.

“The virus is here, Omicron is in Australia and we are going to live with the virus and not let it drag us back,” Australian Prime Minister Scott Morrison told 4BC radio.

CNN’s Naomi Thomas, Virginia Langmaid, Maggie Fox, Niamh Kennedy, Vasco Cotovio, James Frater, Allegra Goodwin and Caitlin McGee contributed to this report.



Read original article here

US Coronavirus: A Covid-19 ‘viral blizzard’ is about to hit the US, expert says

While the Delta variant is still a worrying presence, there could be millions of more Americans infected within weeks due to the high transmissibility of the Omicron variant, said Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota.
“I think we’re really just about to experience a viral blizzard,” Osterholm told CNN’s Erin Burnett on Thursday. “I think in the next three to eight weeks, we’re going to see millions of Americans are going to be infected with this virus, and that will be overlaid on top of Delta, and we’re not yet sure exactly how that’s going to work out.”
With so many possible cases from Omicron — which scientists believe to be more contagious though most cases so far appear to be mild — there will be a serious strain on the health care system as more workers will likely get sick, Osterholm said.

“What you have here right now is a potential perfect storm,” Osterholm said. “I’ve been very concerned about the fact that we could easily see a quarter or a third of our health care workers quickly becoming cases themselves.”

Andy Slavitt, a former senior pandemic adviser to President Joe Biden, said that while tools such as vaccines are now available rather than during last winter’s surge, “a very rough January” lies ahead due to Omicron.

“For the health care workers, the hospitals, for people who are sick, even sick with things other than Covid, that represents a real danger and a real threat,” Slavitt told CNN’s Don Lemon on Thursday.

Various sectors of American life are already showing signs of strain. Some colleges and universities are returning to online learning. Sports leagues are postponing games due to players testing positive, and live shows in theaters are canceling performances.

Long lines for Covid-19 testing were seen Thursday in metro areas such as New York, Boston and Miami.

With Christmas and New Year’s Eve approaching — and the accompanying travel to see friends and families — getting vaccinated or boosted remains key.
Recent lab studies of blood that was taken from vaccinated people and exposed to engineered copies of Omicron showed that the variant can evade some protection offered by two doses of Moderna’s Covid-19 vaccine, but a booster dose restores much of that immunity, researchers reported Wednesday. The Pfizer/BioNTech vaccine has shown similar results.
The daily rate of vaccinations is up around 22% from a month prior, according to data from the US Centers for Disease Control and Prevention, with more than half of vaccinations being booster doses. At the current pace, it will take more than two months for at least half of adults to get a Covid-19 booster, according to a CNN analysis of CDC data.

Biden said Thursday that vaccinations and boosters are essential to keeping businesses and holiday gatherings safe.

“For the unvaccinated, we are looking at a winter of severe illness and death,” he said. “But there’s good news if you’re vaccinated and you have your booster shot, you’re protected from severe illness and death.”

Vaccines still the best way to fight Covid-19, officials say

Even with the potential spread of the Omicron variant, former Obama White House health policy adviser Dr. Zeke Emanuel said that the US has tools to fight Covid-19 unlike during its onset.

“In March 2020, we didn’t understand a lot about coronavirus. Second of all, we have vaccines now. We have the ability to change those vaccines. We’re getting oral therapeutics. We have much better tests and test availability. None of that’s perfect, but it’s much better than it was in March 2020,” Emanuel told CNN’s Michael Smerconish on Thursday.

Continued research into additional drugs to fight coronavirus is ongoing.
Merck’s Covid-19 antiviral, molnupiravir, lowers the risk of hospitalization or death in high-risk unvaccinated adults by 30%, according to a statement issued after publication of its clinical trial data in the New England Journal of Medicine.

Among people who got the treatment, the risk of hospitalization and death was 6.8%, compared with 9.7% among people who got a placebo, the study said. There was one death in the treatment group, compared with nine deaths in the placebo group.

While successes are being found in some treatments pre- and post-infection, the rates of severe disease and death for those vaccinated continue to prove much lower even with data showing vaccines’ reduced effectiveness against certain variants.

“Given the increased risk related to the Delta and Omicron variant, it is important to increase uptake of primary vaccination and booster doses in all eligible populations,” said Heather Scobie, a member of the CDC’s Enhanced Surveillance Epidemiology Task Force Covid-19 Emergency Response.

People can travel safely with precautions, Fauci says

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said he is certain Omicron will become the dominant variant relatively soon.

“It has what we call a doubling time of about three days. And if you do the math on that, if you have just a couple of percentage of the isolates being Omicron, very soon it’s going to be the dominant variant,” he told ABC’s “Good Morning America.”

Yet as long as people get vaccinated and utilize precautions such as mask-wearing, Fauci said, lockdowns seen last year may not be needed and traveling for a Christmas with other vaccinated people can be done safely.

“If you are vaccinated, and particularly if you are boosted, you’re going to have to wear a mask on the plane anyway. That’s a regulation. But be prudent and careful. When you go to the airport, particularly, that’s an indoor congregate setting,” Fauci told CNN’s Wolf Blitzer.

“I believe that if people follow the recommendations of the CDC about indoor masking, take the advice of getting vaccinated and getting boosted, we should be fine for the holidays, and we should enjoy it with our family and our friends.”

CNN’s Jen Christensen, Maggie Fox, Deidre McPhillips, Jacqueline Howard, Naomi Thomas, Virginia Langmaid, Allie Malloy, John Bonifield and Katherine Dillinger contributed to this report.

Read original article here

Omicron variant symptoms: 5 symptoms you shouldn’t ignore

The omicron variant of the coronavirus continues to spread throughout the world, and now we have an idea of what omicron symptoms look like for infected people.

The ZOE COVID Study, which has analyzed thousands of COVID-19 cases and reported on symptoms of those cases, has revealed the top symptoms for people who were infected with the coronavirus at the time when the omicron variant likely started to spread, according to CNBC.

The symptoms appeared to be similar to other coronavirus variants. Here’s a look at the top five symptoms:

  1. Runny nose.
  2. Headache.
  3. Fatigue (either mild or severe).
  4. Sneezing.
  5. Sore throat.

Professor Tim Spector, the lead scientist on the ZOE COVID Study app, said there’s a risk you might think omicron is a normal cold, but you shouldn’t ignore the signs, according to The Guardian.

  • “Things like fever, cough and loss of smell are now in the minority of symptoms we are seeing,” he said. “Most people don’t have classic symptoms.”

A new researcher paper suggests that the omicron variant of the novel coronavirus causes less severe COVID-19 symptoms compared to early variants of the virus, as I wrote for the Deseret News.

  • However, the virus can evade vaccines and infect fully vaccinated people.

But Gavin Screaton, head of Oxford University’s Medical Sciences Division and lead author of the paper, said booster shots can protect you even more.

  • “Whilst there is no evidence for increased risk of severe disease, or death, from the virus amongst vaccinated populations, we must remain cautious, as greater case numbers will still place a considerable burden on health care systems,” he said, per CNBC.

Read original article here

Columbia study finds Omicron ‘markedly resistant’ to vaccines, boosters may not do much to help

Columbia University researchers found that COVID-19 Omicron is noticeably resistant to vaccines and that boosters may not provide adequate protection just as US cases of the variant soared by 32 per cent in the last 24 hours. 

In a study published Wednesday by Dr. David Ho and 20 other researchers, the scientists discovered that Omicron’s ‘extensive’ mutations can ‘greatly compromise’ all major COVID-19 vaccines – Pfizer, Moderna, Johnson & Johnson and AstraZeneca – even neutralizing them. 

The report also found that while booster shots provided an additional layer of protection, the variant ‘may still pose a risk’ for those who get the third shot.’ 

‘These findings are in line with emerging clinical data on the Omicron variant demonstrating higher rates of reinfection and vaccine breakthroughs,’ the scientists wrote. 

‘Even a third booster shot may not adequately protect against Omicron infection.’ 

Columbia researchers found that all four major COVID-19 vaccines (L-R) Pfizer, Moderna, Johnson & Johnson and AstraZenca failed to consistently provide adequate protection against the Omicron variant. Booster shot protection sometimes fell just above the line of acceptance

Experts and health officials warn that COVID-19 cases will soar in the coming weeks

The study looked at the effectiveness of each major vaccine against the Omicron variant, finding several cases where they failed to provide the needed protection against infection. 

 While the booster shots proved to be overall consistent, some recorded instanced put it right at the threshold of actually being effective. 

Columbia University Professor Dr. David Ho

Ho and the Columbia research team, who worked along side the University of Hong Kong, said the study delivers a grave warning about the future of COVID and its variants. 

‘It is not too far-fetched to think that this [COVID-19] is now only a mutation or two away from being pan-resistant to current antibodies,’ the researchers wrote. 

‘We must devise strategies that anticipate the evolutional direction of the virus and develop agents that target better conserved viral elements.’  

The warning came as confirmed US Omicron cases jumped by a third overnight, from 241 on Wednesday to 319 on Thursday. But experts have warned those are the tip of the iceberg, and that American cases likely already number in the tens of thousands.

Scientists warned that COVID variants could soon undermine current vaccines and immunities

White House COVID tsar Dr. Anthony Fauci even remarked on the variant’s ‘extraordinary’ ability to spread, before revealing that cases will double every three days. 

The number of people testing positive in New York also has doubled in three days, from 3.9 per cent of all swabs coming back positive on December 9, to 7.8 per cent on December 12. More than four fifths of New York

Bill de Blasio’s senior public health adviser Dr. Jay Varman, a Cornell epidemiology professor, tweeted the news, saying: ‘Um, we’ve never seen this before in #NYC. Test positivity doubling in three days.’

A total of 81 per cent of New Yorkers are fully-vaccinated, and 18.5 per cent have received their booster shots – but a worrying new study from Columbia University suggests that neither may be sufficient in protecting from Omicron.

Immunologists have also forecast a potential triple-whammy of Omicron, Delta and regular flu infections this winter. Two doctors interviewed by DailyMail.com said those who haven’t received a booster shot should consider returning to Spring 2020-style self-isolation, when COVID’s Alpha variant raged through the US, and no vaccines were available.

Dr Anthony Fauci (pictured), the nation’s top infectious disease expert told Good Morning America on Thursday that Omicron transmits very efficiently, and the current outbreaks overseas are signs of things to come for the U.S. if more people do not get boosted

Speaking on Good Morning America on Thursday, Fauci also confirmed Omicron was on track to be the dominant Covid strain in America within weeks.

He said: ‘Certainly what [Omicron] is showing us in other countries [is that it spreads faster than other variants] and I believe soon in our own country.

‘It has an extraordinary ability to transmit efficiently and spread. It has what we call a doubling time of around three days.

‘And if you do the math on that, if you have just a couple of percentage of the isolates being Omicron, very soon it’s going to be the dominant variant. We’ve seen that in South Africa, we’re seeing it in the U.K. and I’m absolutely certain that’s what we’re going to be seeing here relatively soon.’

The doubling time of three days is slightly longer than the 2.5 days reported by British and South African health officials. On Thursday, the UK recorded its second-consecutive day of record infections – 88,376 – 24 hours after Wednesday’s total of 78,610. That is a 74 per cent jump in a week, with 15 people who’ve been infected with Omicron so-far hospitalized in the UK.

The US is much larger, with most of its landmass not as densely populated as the UK or South Africa.

But Omicron is believed to represent up to 13 per cent of new diagnoses in New Jersey and New York – states with extremely well-populated areas – giving a possible early taste of what’s to come with the new strain. 

Fauci continues to urge Americans to get vaccinated, and boosted, to protect themselves from the virus, especially now with the new threat of Omicron circulating. A total of 16.5 per cent of Americans have so-far had the booster shot. 

‘We need to do everything that we have been talking about up to now, and even more so,’ he said.  

He spoke hours after the CDC agency released forecasts on Wednesday night showing that weekly Covid cases will increase by 55 percent to 1.3 million per week – or 185,714 per day – by Christmas. 

It also predicted deaths with jump by 73 percent to up to 15,600 per day by early January – or 2,228 deaths per day.

Some of that predicted surge is already appearing in parts of the country, with Florida revealing 6,381 new cases on Thursday – the state’s largest single day Covid increase since September.

The Delta variant is still the dominant Covid strain in the U.S., accounting for around 97 percent of sequenced cases. Omicron is quickly making up ground, though, with the newly discovered variant jumping seven-fold in a week from making up 0.4 percent of cases to 2.9 percent of case, according to the most recent CDC data. 

The graphs show the amount of the coronavirus detected in human bronchial cells (left) and lung cells (right) 24 and 48 hours after coming into contact with the original strain of the virus (pink), Delta (orange) and Omicron (red). There was 70 times more Omicron recorded in the bronchus — the main pipe connecting the airways and lungs — compared to previous strains, but 10 times less virus in the lungs when compared to the original version and Delta. Experts from the University of Hong Kong said this suggests the virus is more transmissible but may cause less severe illness

Lori Tremmel Freeman, chief executive officer of the National Association of County and City Health Officials, has warned of a nightmare scenario where Delta, Omicron and regular seasonal flu could combine to inflict the winter from hell on US hospitals already struggling to cope with an influx of patients. 

She told CNN: ‘It’s the combination. It’s kind of the perfect storm of public health impacts here with Delta already impacting many areas of the country and jurisdictions. We don’t want to overwhelm systems more.’ 

Early data also shows that people who are only fully vaccinated, but have not yet received their booster, are still extremely vulnerable to the virus, with Johnson & Johnson’s single-dose shot offering effectively no protection. 

Booster shots have been deemed effective against the variant, though, with both Moderna and Pfizer revealing data in recent days showing their vaccines will cause massive increases in antibody levels and up to 75 per cent protection from Covid symptoms.

But confusion remains about just how effective boosters are against a strain that was only identified after Americans began receiving them en-masse.

A new study by Columbia University in New York, published on Thursday, said: ‘Even serum from persons vaccinated and boosted with mRNA-based vaccines exhibited substantially diminished neutralizing activity against (omicron),’

Dr Chris Thompson (pictured), an infectious disease expert at Loyola University of Maryland, said that Americans who have not yet been boosted should bring back some early-pandemic habits

Only around 16.5 percent of Americans have received the additional vaccine dose so far though – as they were not widely available until late November – meaning that more than 80 percent of Americans are at risk from Omicron.

Dr Chris Thompson is an infectious disease expert at Loyola University of Maryland. He told DailyMail.com on Thursday that people who have not received their booster dose yet may want to bring back some early pandemic habits like social distancing, masking, frequent hand washing and more.

‘The data that I’ve seen says that you’re about 33 percent protected after a two dose regimen of either of the mRNA vaccines [the Pfizer or Moderna shots] and we don’t have good data from Johnson and Johnson’s vaccine yet. Then if you get your booster you look like you get back up into the 75 percent protection range and for preventing disease’

Whether Delta or Omicron, U.S. is experiencing yet another surge of Covid cases during the holiday season. The nation is recording 121,188 new cases every day – a 40 percent increase over the past two weeks. Deaths are making a sharp rise as well, up 34 percent to 1,302 per week. 

The number of Americans hospitalized with the virus increased over the past 14 days as well, up 21 percent to 68,079.

The Centers for Disease Control and Prevention projects that the situation will only worsen as well.

Read original article here