Category Archives: Health

How Healthy is Your Heart? Find Out at Home Without Any Equipment

Your heart plays a key role in your body, delivering oxygen to every other organ and keeping you alive. That’s why it’s so important to be heart healthy in every sense of the word, from your blood pressure to your cholesterol levels and more. While some heart health metrics are best left to professionals, others can be checked easily at home. 

Staying up to speed on your heart health can help you avoid any issues, or catch them early. Heart disease is the leading cause of death for most racial and ethnic groups in the US, per the US Centers for Disease Control and Prevention, and someone in the US has a heart attack every 40 seconds.

To be clear, we do recommend regularly getting your heart checked out by a pro. But in the meantime, there are ways to monitor your own heart health yourself, right in the comfort of your home, without any special devices — you just need a few minutes and a bit of math.

Here are two easy ways to measure your heart health at home without equipment. Plus, learn the most common signs and symptoms of heart problems to look out for.

Try the stairs test


MStudioImages/Getty Images

Do you get out of breath while walking up the stairs? One 2020 study by the European Society of Cardiology found that you can assess your heart health by timing how long it takes you to ascend four flights of stairs. 

“If it takes you more than 1½ minutes to ascend four flights of stairs, your health is suboptimal, and it would be a good idea to consult a doctor,” explains study author Dr. Jesús Peteiro, a cardiologist at University Hospital A Coruña, Spain.

The study compared the results of the stairs test and more in-depth medical tests of heart health, like a treadmill test. They found some overlap — 58% of patients who took longer than 1½ minutes to complete the stairs test had “abnormal heart function during the treadmill examination,” per the study. People who took less time to ascend the stairs also had higher exercise capacity, which in turn is linked with a lower mortality rate.

Dr. Peteiro also authored a 2018 study in which over 12,000 participants walked up three flights of stairs. Those who weren’t able to do it quickly were nearly three times more likely to die from heart disease over the next five years (3.2% compared to 1.7%).

Notably, both studies only looked at people with symptoms of coronary artery disease. But Dr. Peteiro said that, when it comes to measuring exercise capacity, the stairs test should work similarly in the general population. And various types of step tests have long been used by medical professionals to assess heart and lung fitness.

Check your heart rate


Lord Henri Voton/Getty Images

Your heart rate, also known as your pulse, is a basic measurement of heart health, which is why your doctor or nurse often listens for it during check-ups. It’s easy to measure at home with no equipment and offers useful information about your heart and overall fitness.

Your heart rate naturally changes throughout the day, depending on how much you’re exerting yourself. During moments of high stress or intense physical exertion, for example, your heart beats faster. When you’re relaxed or asleep, it beats more slowly.

There are two types of heart rate you can measure at home: resting heart rate and maximum heart rate. First, we’ll go over what each one means. Then we’ll explain how to measure.

Resting heart rate

Your “resting heart rate” is your pulse at rest, when you’re relaxed and still. Research shows that higher resting heart rates, are linked with lower physical fitness, higher blood pressure, and an increased risk of heart attack and death.

What’s “low” or “normal” varies a bit by the individual. In general, healthy adult heart rates range from 60 to 100 beats per minute, but ranges also depend on age. Here are the target resting heart rate ranges for various age groups:

Age

Target Resting Heart Rate 

20 years

100 – 170 beats per minute (bpm)

30 years

95 – 162 bpm

40 years

90 – 153 bpm

50 years

85 – 145 bpm

60 years

80 – 136 bpm

70 years

75 – 128 bpm

Maximum heart rate

In addition to your resting heart rate, you can also measure your heart rate during exercise. This gives you an idea of how fast your heart beats when it’s working extra hard, and how close it is to your “maximum heart rate” — the highest that your heart rate should ever go. To get your maximum heart rate, subtract your age from 220.

In this case, lower isn’t necessarily better. During moderate-intensity physical exercise, you should aim to get between 64% and 75% of your maximum heart rate, per the CDC. And during vigorous-intensity exercise, your should be between 77% and 93% of your maximum heart rate.

Your maximum heart rate has to do with how much aerobic capacity your body has. Studies have found that higher aerobic capacity is associated with less likelihood of heart attack and death, Harvard Health reports.

How to measure your heart rate at home

There are a few places on your body where you can feel your pulse. One common and easily accessible location is the radial artery, or your wrist. 

Simply put your index and middle finger on the inside of the opposite wrist, and count the number of heartbeats you feel in 15 seconds. Multiply that number by four to get your heart rate in beats per minute. (Start the count on a beat, which is counted as zero.)

The best time to measure your resting heart rate is in the morning when you wake up, while you’re still in bed. 

To measure your heart rate during exercise, you’ll have to pause briefly in the middle of exercising to measure your pulse. You can also use a heart rate monitor or fitness tracker, if you have one (the most accurate measurements come from a chest-strap heart rate monitor).

Know the sneaky signs of heart disease


ljubaphoto/Getty Images

Many people with cardiovascular diseases go undiagnosed until it’s too late. Here are some of the most common symptoms of heart attack, heart disease, heart failure and other urgent cardiovascular health concerns to look out for, courtesy of the Mayo Clinic.

  • Chest pain, tightness
  • Shortness of breath
  • Swelling in the hands, legs, ankles or feet
  • Upper back or back pain
  • Rapid or irregular heartbeat (or palpitations)
  • Changes in heart rhythm
  • Weakness or dizziness
  • Numbness in the legs or arms
  • Lightheaded or dizziness
  • Fatigue or weakness during physical activity
  • Heartburn, nausea or vomiting
  • Fainting

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

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El Paso Health official discusses what first confirmed Monkeypox case means for El Paso

EL PASO, Texas — Health experts discuss what the first confirmed case of Monkey Pox means for El Paso.

“We knew this was gonna happen eventually just like with SARS-COVID 2 it happened in a lot of places around the country and eventually got to El Paso,” said Ogechika Alozie E.O at Sunset West Health.

Monkeypox is a viral disease that can be spread through skin-to-skin contact. It resembles a rash with blisters it can be painful or itchy. Symptoms of Monkeypox include rash, fever, chills, swollen lymph nodes, and exhaustion.

Now that it’s made its way to El Paso health experts say the general public should not be worried.

“This is not airborne this is close physical contact up till now 98 to 99 percent of the person’s who’ve gotten this have been men// the majority of El Pasoans aren’t at risk for this,” said Alozie.

Still, some El Pasoans were concerned.

“I think that’s pretty crazy I mean we aren’t even really out of the woods with covid yet we’re still getting cases with that and then now we have Monkeypox coming up so it’s honestly kind of scary,” said El Pasoan Scott Turner.

Doctor Alozie says on average a person with Monkeypox can be contagious for up to 21 days, The lesions and bumps can last another 3 weeks. As long as those are present a person is contagious. He offers this advice if you catch Monkeypox.

“If you’re sick take yourself out of circulation if you have lesions take yourself out of circulation go see your physician and try to figure out what it is and if you’re in contact with somebody that may have lesions its best for you to avoid them for a while,” said Alozie.

“I feel like we just got over one and now we’re going through another one so it is kind of overwhelming but I mean all we can do is keep going forward and have trust,” Selena Abdalla.

Alozie added Monkeypox unlike COVID is spread through tighter social networks with close physical contact on average of 3 hours.

According to a news release:

“Public Health officials confirmed that a female in her 50s is the community’s first confirmed Monkeypox case. She is currently recovering at home and the City’s epidemiology team has begun an investigation and contact tracing.”

An epidemiology team is working to identify close contacts to offer them vaccines.

El Paso received 200 doses of the Monkeypox vaccine earlier this month.

“Monkeypox continues to be a global threat and for this reason, we strongly recommend everyone continue practicing safety precautions to keep themselves and their family, especially our most vulnerable loved ones, safe from all diseases, whether it is COVID, Monkeypox, or the flu,” said City-County Health Authority Dr. Hector Ocaranza.

This is a developing news story. Download the KVIA news app to get alerts the moment news breaks.

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experts give virus variants new names

A group of global experts convened by WHO has agreed on new names for monkeypox virus variants, as part of ongoing efforts to align the names of the monkeypox disease, virus and variants—or clades—with current best practices. The experts agreed to name the clades using Roman numerals.

The monkeypox virus was named upon first discovery in 1958, before current best practices in naming diseases and viruses were adopted. Similarly for the name of the disease it causes. Major variants were identified by the geographic regions where they were known to circulate.

Current best practise is that newly-identified viruses, related disease, and virus variants should be given names with the aim to avoid causing offense to any cultural, social, national, regional, professional, or ethnic groups, and minimize any negative impact on trade, travel, tourism or animal welfare.

Disease: Assigning new names to existing diseases is the responsibility of WHO under the International Classification of Diseases and the WHO Family of International Health Related Classifications (WHO-FIC). WHO is holding an open consultation for a new disease name for monkeypox. Anyone wishing to propose new names can do so here (see ICD-11, Add proposals).

Virus: The naming of virus species is the responsibility of the International Committee on the Taxonomy of Viruses (ICTV), which has a process underway for the name of the monkeypox virus. 

Variants/clades: The naming of variants for existing pathogens is normally the result of debate amongst scientists. In order to expedite agreement in the context of the current outbreak, WHO convened an ad hoc meeting on 8 August to enable virologists and public health experts to reach consensus on new terminology.

Experts in pox virology, evolutionary biology and representatives of research institutes from across the globe reviewed the phylogeny and nomenclature of known and new monkeypox virus variants or clades. They discussed the characteristics and evolution of monkeypox virus variants, their apparent phylogenetic and clinical differences, and potential consequences for public health and future virological and evolutionary research.

The group reached consensus on new nomenclature for the virus clades that is in line with best practices. They agreed on how the virus clades should be recorded and classified on genome sequence repository sites.

Consensus was reached to now refer to the former Congo Basin (Central African) clade as Clade one (I) and the former West African clade as Clade two (II). Additionally, it was agreed that the Clade II consists of two subclades.

The proper naming structure will be represented by a Roman numeral for the clade and a lower-case alphanumeric character for the subclades. Thus, the new naming convention comprises Clade I, Clade IIa and Clade IIb, with the latter referring primarily to the group of variants largely circulating in the 2022 global outbreak. The naming of lineages will be as proposed by scientists as the outbreak evolves. Experts will be reconvened as needed.

The new names for the clades should go into effect immediately while work continues on the disease and virus names.

 

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Vitamin D Supplementation Seems to Alleviate Depressive Symptoms in Adults

Summary: The findings of an extensive meta-analysis study reveal vitamin D supplementation may help to alleviate symptoms of depression.

Source: University of Eastern Finland

An extensive meta-analysis suggests that vitamin D supplementation may alleviate depressive symptoms in adults with depression. Conducted by an international team of researchers, the meta-analysis includes dozens of studies from around the world.

Depressive symptoms cause a significant disease burden worldwide. The therapeutic efficacy of current antidepressants is often insufficient, which is why further ways to alleviate the symptoms of depression have been sought, for example, from nutritional research.

Vitamin D is believed to regulate central nervous system functions the disturbances of which have been associated with depression. In addition, cross-sectional studies have observed an association between depressive symptoms and vitamin D deficiency.

However, previous meta-analyses on the effects of vitamin D supplementation on depression have been inconclusive. In a meta-analysis, results from several different studies are combined and analyzed statistically.

The new meta-analysis on the association of vitamin D supplementation with depression is the largest one published so far, including results from 41 studies from around the world.

These studies have investigated the efficacy of vitamin D in alleviating depressive symptoms in adults by randomized placebo-controlled trials in different populations.

The studies included those carried out in patients with depression, in the general population, and in people with various physical conditions.

Vitamin D is believed to regulate central nervous system functions the disturbances of which have been associated with depression. Image is in the public domain

The results of the meta-analysis show that vitamin D supplementation is more effective than a placebo in alleviating depressive symptoms in people with depression. There were major differences in the vitamin D doses used, but typically the vitamin D supplement was 50–100 micrograms per day.

“Despite the broad scope of this meta-analysis, the certainty of evidence remains low due to the heterogeneity of the populations studied and the due to the risk of bias associated with a large number of studies,” Doctoral Researcher and lead author Tuomas Mikola of the Institute of Clinical Medicine at the University of Eastern Finland says. The meta-analysis is part of Mikola’s Ph.D. thesis.

“These findings will encourage new, high-level clinical trials in patients with depression in order to shed more light on the possible role of vitamin D supplementation in the treatment of depression,” Mikola concludes.

The meta-analysis was published in Critical Reviews in Food Science and Nutrition and carried out in international collaboration between Finnish, Australian and U.S. researchers.

About this depression and vitamin D research news

Author: Press Office
Source: University of Eastern Finland
Contact: Press Office – University of Eastern Finland
Image: The image is in the public domain

Original Research: Closed access.
“The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials” by Tuomas Mikola et al. Critical Reviews in Food Science and Nutrition


Abstract

See also

The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials

Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta‐analyses investigating the effect of vitamin D on depression have been inconsistent.

This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials (RCT).

General and clinical populations, and studies of ill individuals with systemic diseases were included. Light therapy, co-supplementation (except calcium) and bipolar disorder were exclusionary.

Databases Medline, PsycINFO, CINAHL and The Cochrane Library were searched to identify relevant articles in English published before April 2022. Cochrane risk-of-bias tool (RoB 2) and GRADE were used to appraise studies. Forty-one RCTs (n = 53,235) were included. Analyses based on random-effects models were performed with the Comprehensive Meta-analysis Software.

Results for main outcome (n = 53,235) revealed a positive effect of vitamin D on depressive symptoms (Hedges’ g = −0.317, 95% CI [−0.405, −0.230], p < 0.001, I2 = 88.16%; GRADE: very low certainty). RoB assessment was concerning in most studies. Notwithstanding high heterogeneity, vitamin D supplementation ≥ 2,000 IU/day appears to reduce depressive symptoms.

Future research should investigate possible benefits of augmenting standard treatments with vitamin D in clinical depression.

PROSPERO registration number: CRD42020149760. Funding: Finnish Medical Foundation, grant 4120 and Juho Vainio Foundation, grant 202100353.

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Why is The Villages known as ‘the STD capital of America?’

Friends up north and across Tampa Bay snickered when Brian Lafferty revealed where he’d bought a new home.

His 30-year-old daughter in Boston called to express concern.

Even his ex-wife asked him about it.

“Without exception, every person I’ve told I bought a house in The Villages has asked the same thing,” Lafferty said. “‘Isn’t that the STD capital of the United States?’”

Related: Why are young people moving to The Villages?

The Villages, a mammoth retirement community that was the fastest-growing metropolitan area in the nation two years ago, is no stranger to folklore. The central Florida senior haven has fielded rumors about swingers and public sex for decades.

Golf carts line the streets near the Brownwood Paddock Square area pictured on Wednesday, Aug. 10, 2022 in The Villages. [ LUIS SANTANA | Times ]

But perhaps no myth is more ubiquitous — or more enduring — than the idea of rampant rates of sexually transmitted diseases.

“I feel like I have to justify to every single person I know that I didn’t buy this place to chase women,” said Lafferty, who is 69 and single. “I bought it because I want to play golf.”

Sexually transmitted infections are on the rise nationally in the wake of the pandemic. But is the world’s largest retirement community — about 80 miles northeast of Tampa — really a hotbed for these diseases?

Where did this pervasive legend start? And will it ever go away?

Related: Documentary on the Villages shows it is not a utopia for everyone

‘More worried about alligators than crabs’

Residents hear the joke all too often. A Tampa Bay Times inquiry on the 38,000-member Facebook group, “The Villages Word of Mouth,” was revealing.

“My doctor in Ohio even, when he asked where we spend time in Florida, stated ‘Oh, The Villages — the highest STD rate in the country,’” wrote Jan Schweitzer on the post.

“We are more worried about alligators than crabs here,” typed Sean Donnelly.

Roy Rowlett wrote: “It doesn’t matter what the truth is. Some people love gossip about old people and sex.”

A moderator disabled comments on the post within days. It had received more than 300 responses.

Rumors abound about how the STD rumor started.

Some say a disgruntled nurse hurled it as an insult. Others believe it began with a joke on a radio station. But most trace it to a 2006 television news story “Doctors in Retirement Community Seeing Increase in STDs.”

“While statistics aren’t yet reflecting the trend, one physician at the Women’s Center of The Villages said, even in her years working in Miami, she has never seen so many cases,” the since-removed WFTV article reported.

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The Women’s Center of The Villages is no longer open. And the doctor was never named.

The myth snowballed from there. It appeared over the years everywhere from the New York Post to the Daily Mail. Often, the stories seized on signs that The Villagers were engaging in casual sex or dating, wielding them as evidence of heavy transmission within the retirement community.

Sometimes, they cited data about the state’s rising rates of sexually transmitted infections among seniors as proof that the same held true in The Villages.

In 2009, the New York Post called The Villages “ground zero for geriatrics who are seriously getting it on.”

“As a result, the place that likes to bill itself as ‘America’s Friendliest Hometown’ has seen a huge increase in sexually transmitted diseases,” according to a 2013 Slate article referencing the tabloid’s coverage. It cited two links that are no longer active, including the 2006 story.

“It had legs,” said Andrew Blechman, author of “Leisureville: Adventures in a World Without Children,” a 2009 book on life in The Villages that is referenced in almost all coverage of this issue. “It’s irresistible — no one wants to think about their parents having sex, but they love news articles about old people having sex. ‘STDs. Old People. Highest rates.’ It’s an easy headline. It’ll never go away.”

Is it true?

Residents of The Villages are, of course, sexually active, said Dr. Marivic Villa, an internist who runs a health clinic in the retirement community.

Many of her patients come seeking testosterone therapy to improve their sex lives. All of them are tested for sexually transmitted diseases.

“In reality, I don’t see much STDs,” said Villa, who has worked in The Villages almost two decades. “Compared to other practitioners, I should. People just want to paint the picture that old people here are like young people in New Orleans.

“I’m not saying that they’re not thinking about having sex,” she added. “They do — a lot — but not to the point that there’s STDs left and right and all over the place.”

Residents walk the along the shops and restaurants in the Brownwood Paddock Square area of The Villages on Wednesday, Aug. 10, 2022. [ LUIS SANTANA | Times ]

Florida tracks sexually transmitted diseases by county of residence. A state Department of Health official declined to parse out the agency’s data on a more granular level, such as a census-designated place like The Villages, citing privacy concerns.

Covering an area larger than Manhattan, The Villages spans three Florida counties — Sumter, Marion and Lake.

Rates of bacterial sexually transmitted diseases — gonorrhea, syphilis and chlamydia — among people 55 and older have slightly trended upwards in these counties since 2006, the year the myth about The Villages is believed to have begun.

But so have sexually transmitted disease rates everywhere.

Since the 2000s, lawmakers have reallocated money for sexual health, a move that experts often credit with contributing to a nationwide spike. When barriers to health care are high, so are rates of sexually transmitted diseases, studies show.

Compared to Florida overall, however, the three counties containing The Villages tended to have significantly lower rates.

Sumter County had one of the lowest rates of sexually transmitted diseases among older adults in 2019 —with about one in 10,000. That’s compared to six in 10,000 seniors statewide. Marion and Lake bore similar trends. The same patterns emerged for diagnoses of human immunodeficiency virus, also known as HIV, among Florida’s older adults.

At the county-by-county level, The Villages similarly fared better than most.

Spread of sexually transmitted diseases among older adults in Florida tended to be higher in counties with major cities and large Black and Latino populations, state data suggest, such as Hillsborough, Miami-Dade and Broward counties. People of color, LGBTQ people and women experience disproportionately high rates of sexually transmitted diseases due to social determinants of health that are more likely to impact marginalized groups.

In The Villages, 86% of seniors are white, according to U.S. Census data. And the percentage of older adults living in poverty is slightly lower than the national rate, suggesting its retirees may have better access to health care than the country as a whole.

‘A punchline’

While sexually transmitted diseases like gonorrhea and syphilis are surging nationwide, much of this nascent spread is among adults in their teens and 20s, according to Centers for Disease Control and Prevention data. Half of all infections are among people 15 to 24.

But rumors travel fast in communities with shared values and histories. In the United States, sexually transmitted diseases carry salacious weight — despite being remarkably common and highly treatable — due to ongoing stigma, said Elizabeth Finley, spokesperson for the National Coalition of S.T.D. Directors.

“One of the pervasive characteristics of sexually transmitted infections is that people turn them into a punchline,” Finley said. “Because there’s so much shame associated with them.”

Blechman, the author of Leisureville, suspected ageism plays a role.

“This really has nothing to do with concern about high STD rates — it has to do with old people having sex,” he said. “People who are older are just people who are older. And they should be treated with respect, not as a caricature.”

Many Villagers agreed, noting they’ve never heard the myth from someone living in the community.

“I think there’s a little bit of jealousy from the outside,” said Christine Wynne, a 50-year-old resident. “‘Oh, you don’t want to move there, there’s STDs.’ It’s utopia here. It’s safe, and everyone’s happy. I think that fueled some of those rumors.”

Aerial view of a water tower and community pictured on Wednesday, Aug. 10, 2022 in The Villages. [ LUIS SANTANA | Times ]

Some residents wondered why Mark Morse, the developer who owns The Villages, hadn’t spoken out to correct the record.

Notoriously averse to media interviews, Morse and The Villages community relations team did not respond to multiple requests for comment.

But Lafferty has a theory.

“It goes back to the old advertising world saying,” he said. “‘Any publicity is good publicity.’”

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Polio Is In New York, So Now People Are Texting Their Parents Asking If They Are Vaccinated

If you are not vaccinated against polio, you should get three doses of a vaccine, according to the CDC. The first two doses should be separated by one to two months and the third dose should be given 6 to 12 months after the second dose.

Dr. Waleed Javaid, a hospital epidemiologist and director of infection prevention and control at Mount Sinai Downtown, told BuzzFeed News not to worry, though. He said most people should be vaccinated but to check with your doctor to be sure.

“We are living in a time where we have seen a pandemic of COVID, followed by a spread of monkeypox, and this has raised our awareness to a different level,” he said. “We all are already worried about why are all these infections coming in our way and what I would say to that is that COVID and monkeypox, we really didn’t have good vaccination plans or processes, but polio, we have successful strategy, successful vaccination that has eradicated for the most part polio in many parts of the world.”

For more on what you need to know about polio, go here.

After health officials announced the polio virus is in New York’s wastewater, people tweeted about their confusion over whether they had received the vaccine when they were young. And stories of the ensuing interactions with their parents quickly spread on social media.

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Research Finds Biomarkers in Older Adults With Late-Life Depression

Summary: The biological changes that occur as a result of aging could be a mechanism behind why older adults with depression do not have a full resolution of symptoms following taking antidepressants.

Source: UConn

Major depression in older adults is very common, disabling, and increases the risk of many diseases of aging, including Alzheimer’s disease and other dementias, cardiovascular issues and even mortality. Therefore, it constitutes a major public health issue, especially considering the growing number of older adults in the U.S. and worldwide.

Many older adults with depression do not experience full resolution of their depressive symptoms with antidepressant treatment.

Improving or achieving full resolution of depression in older adults is a major clinical challenge, and approximately 50% of patients experience persistent depressive symptoms after antidepressant treatment.

The persistence of depressive symptoms becomes a source of depleted psychological well-being, increased disability, accelerated cognitive decline, and premature aging in older adults.

Therefore, identifying the mechanisms and factors associated with treatment outcomes in this population is key for improving therapeutics and identifying those individuals for whom antidepressant treatment would be more effective.

Dr. Breno Diniz, associate professor of psychiatry at the UConn Center on Aging at UConn Health and his colleagues addressed these issues in a study published on June 30, 2022 in JAMA Network Open.

They used a recently developed composite biomarker index associated with cellular and molecular senescence [the senescence-associated secretory phenotype, SASP] to test the hypothesis that biological changes that occur with aging are one of the mechanisms of poor treatment outcomes in older adults with depression.

They found that higher SASP index scores were significantly associated with a lower likelihood of full resolution of the depressive symptoms after antidepressant treatment.

Many older adults with depression do not experience full resolution of their depressive symptoms with antidepressant treatment. Image is in the public domain

These findings are important because they highlight the importance of age-related biological abnormalities, reflected in the SASP index, as a potential mechanism related to treatment resistance to antidepressants in older adults.

This investigation opens up new possibilities to investigate alternative interventions to improve the odds of responding to antidepressant treatment in this population, for example, by testing whether senolytic drugs can improve rates of treatment remission in older adults with depression.

Also, the measurement of the SASP index biomarkers can help to identify those individuals in which treatment would be futile at the treatment outset.

These findings can inform a path forward for geroscience-guided interventions targeting senescence to improve depressive symptoms older adults.

About this aging and depression research news

Author: Press Office
Source: UConn
Contact: Press Office – UConn
Image: The image is in the public domain

Original Research: Open access.
“Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome” by Breno S. Diniz et al. JAMA Network Open


Abstract

Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome

Importance  

Many older adults with depression do not experience remission with antidepressant treatment, and markers of cellular senescence in late-life depression (LLD) are associated with greater severity of depression, greater executive dysfunction, and higher medical illness burden. Since these clinical characteristics are associated with remission in LLD, molecular and cellular senescence abnormalities could be a possible biological mechanism underlying poor treatment response in this population.

Objective  

To examine whether the senescence-associated secretory phenotype (SASP) index was associated with the likelihood of remission from a depressive episode in older adults.

Design, Setting, and Participants  

See also

A nonrandomized, open-label clinical trial was conducted between August 2009 and August 2014 in Pittsburgh, Pennsylvania; St Louis, Missouri; and Toronto, Ontario, Canada, with older adults in a current major depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) diagnostic criteria. Data from biomarker analyses were reported according to the clinical trial archived plasma samples run in March 2021. Data were analyzed from June to November 2021.

Exposure  

Venlafaxine extended release (dose ranging from 37.5 mg to 300 mg daily) for up to 12 weeks.

Main Outcomes and Measures  

The association between a composite biomarker-based index (SASP index) and treatment remission in older adults with major depression was measured using clinical data and blood samples.

Results  

There were 416 participants with a mean (SD) age of 60.02 (7.13) years; 64% (265 participants) were self-reported female, and the mean (SD) Montgomery-Asberg Depression Rating Scale score was 26.6 (5.7). Higher SASP index scores were independently associated with higher rates of nonremission, with an increase of 1 unit in the SASP index score increasing the odds of nonremission by 19% (adjusted odds ratio, 1.19; 95% CI, 1.05-1.35; P = .006). In contrast, no individual SASP factors were associated with remission in LLD.

Conclusions and Relevance  

Using clinical data and blood samples from a nonrandomized clinical trial, the results of this study suggest that molecular and cellular senescence, as measured with the SASP index, is associated with worse treatment outcomes in LLD. Combining this index score reflecting interrelated biological processes with other molecular, clinical, and neuroimaging markers may be useful in evaluating antidepressant treatment outcomes. These findings inform a path forward for geroscience-guided interventions targeting senescence to improve remission rates in LLD.

Trial Registration  

ClinicalTrials.gov Identifier: NCT00892047

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These are the 8 best fruits for your health, according to nutritionists

NEWYou can now listen to Fox News articles!

Blueberries, apples and mangoes — oh my! 

Nutritionists weigh in on the best fruits to support good health if you’re in the process of adding more fruit to your diet.

Consider loading up on these antioxidant-packed superstars as a snack, blended into a smoothie — or as a part of a balanced, healthy breakfast or lunch.

They’re truly easy to work into just about any meal. 

FRUIT OR VEGETABLE? TAKE THIS QUIZ TO TEST YOUR HEALTHY FOODS KNOWLEDGE!

And as you’ll see, doing so is a very smart move. 

Blueberries

Add tiny but mighty blueberries to your next bowl of cereal or oatmeal. 

Marie Ruggles, the New York City-based author of “Optimize Your Immune System: Create Health & Resilience with a Kitchen Pharmacy,” called these berries her favorite fruit. 

“Compounds in berries have been shown to regulate cell behavior, leading to a protective effect on the prevention and treatment of several dreaded diseases including cancer, diabetes, and heart disease,” she said, citing this research. 

Blueberries have been shown to prevent the development of cancer and diabetes.
(iStock)

“Berries, in general, make for a very healthy addition to any diet. Frozen berries are a great option for those times of the year when the fresh options are more limited,” Ruggles added.

Jinan Banna, a registered dietitian and professor of nutrition in Hawaii, added that a review of the health-promoting properties of blueberries highlights some evidence about blueberry consumption and disease prevention. 

“The review mentions the antioxidant content of this fruit as being key in promoting health,” she said.

KETO DIET: WHAT IS IT AND HOW MANY CARBS DO I EAT PER DAY?

Apples

You know the saying … (“An apple a day …”).

Well, it may be high time to incorporate this nutrient-dense fruit into your diet. 

Apples have great health benefits; they provide great fiber.
(Fannin County Chamber of Commerce)

“Apples are a great choice, as they provide fiber and important micronutrients,” said Banna. 

“Their benefits in terms of prevention of chronic disease such as cancer have also been highlighted,” she said, noting a particular scientific article. “The authors mention the rich phytochemical content, which has the potential to improve health and reduce disease risk.”

Mangoes

This tropical fruit is worth adding to your meals, according to experts.

“Mango is a good source of fiber, which is important to help you stay full and have healthy digestion, among other functions,” said Banna. 

“As a fruit, mango does not have any added sugar that you would find in packaged foods, but does contain sugar naturally.” 

THESE ARE THE BEST IMMUNE-BOOSTING FOODS, ACCORDING TO NUTRITION EXPERTS

“Mango also contains many vitamins and minerals that are essential for the body’s functioning,” she said, adding that mango is a good source of vitamin C, vitamin A, copper, folate and others. It also contains numerous antioxidants. 

Mangoes are a great source of fiber and can help with digestion. They’re also good for skin and hair because of their high Vitamin A content.
(iStock)

Two such antioxidants? Those would be beta-carotene and zeaxanthin, the latter of which may reduce the risk of age-related macular degeneration. 

“It does so by filtering out harmful blue light rays and protecting eye health,” said Kansas-based ​registered dietitian Cheryl Mussatto.

If you want a smooth complexion and shiny hair, Mussatto also urges people to reach for a mango. 

EAT THESE FOODS TO LIVE A LONG LIFE, EXPERTS SAY

“Vitamin A is abundantly found in this fruit, necessary for the growth of all body tissues, including skin and hair,” she told Fox News Digital.

“The production of sebum, an oily, waxy substance secreted from the sebaceous glands, is not possible without vitamin A,” she said. “Sebum helps waterproof and lubricates our skin and hair.”

Bananas

The tasty fruit is also a boon to your health.

“Bananas are a good source of potassium, as well as manganese, magnesium, vitamin C and vitamin B6,” said Banna. 

Bananas are rich in potassium, magnesium and more.
(iStock)

“They also contain bioactive compounds that are implicated in disease prevention,” she said.

Pears

“The modest, underrated pear packs a trove of health benefits,” said Mussatto.

“You wouldn’t guess, but pears are one of the highest fiber fruits around, with an impressive six grams found in a medium-sized fruit.”

“Each day we need 25-30 grams of fiber — and eating pears is perfect for reaching that goal. Soluble fiber is the predominant fiber found in pears, specifically pectin.”

She said as well, “Pectin may help improve digestion, lower cholesterol levels, stabilize blood sugar, and possibly prevent certain cancers.” 

“Soluble fiber is the predominant fiber found in pears, specifically pectin.”
(iStock)

Another bonus of eating pears? 

“The mineral boron, which helps our body retain calcium making bones strong, is also found in this fruit,” added Mussatto.

She said most people can safely eat pears, as they are considered hypoallergenic, meaning those with food sensitivities should be able to eat pears with no side effects.

Kiwis

Add this sweet-tart fruit to your grocery cart.

“Maybe kiwifruit doesn’t catch your eye like brightly colored peppers or ruby red apples, but make no mistake, this small but mighty fruit is a nutritional winner,” said Mussatto.

“Let’s start with the fact that kiwifruit is an exceptional source of vitamin C. Kiwifruit has five times the daily recommended amount of vitamin C than what an orange or lemon provides.”

Kiwis can be a great source of vitamin C. 
(calorificapp.com)

“Vitamin C is a powerful antioxidant, helping eliminate free radicals that can cause inflammation within the body,” she added. 

“It also helps boost immunity against harmful pathogens, in addition to helping our body absorb the mineral iron more efficiently.”

“Kiwifruit is also a good source of folate, a B vitamin,” said Mussatto. 

“Folate is crucial in helping the neural tube to develop properly into the brain and spinal cord of a developing baby, lowering the risk of a baby being born with a neural tube defect such as spina bifida.”

Oranges

Michelle Hawksworth, a registered dietitian for Muscle and Brawn, a biohacking resource for those looking to learn about health, nutrition, working out and supplements, appears to be a big fan of this citrus fruit.

“Oranges are famous for being a great source of vitamin C,” she said. 

“Oranges have a lot of nutrients and antioxidants to help boost the body’s immune system.” 

“They also have high amounts of potassium, Vitamin B1 and fiber. All in all, oranges have a lot of nutrients and antioxidants to help boost the body’s immune system and protect the cells from damage.”

“Research has also shown that eating oranges can help lower inflammation and blood pressure, reduce cholesterol and regulate sugar levels.” 

Oranges are a good source of vitamin C and have a lot of potassium. 
(CactuSoup)

Another benefit of oranges is the beta-carotene content. 

“Oranges are packed with a type of pigment called Beta-carotene which is converted to vitamin A in the body,” said Mackenzie Burgess, a registered dietitian nutritionist and recipe developer at Cheerful Choices. She is based in Denver, Colo.

“Vitamin A is important for vision as well as keeping our immune system strong.”

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“Beta-carotene is also an antioxidant, meaning it helps fight oxidative stress in the body, and has been found to have a beneficial effect on brain function,” she added. 

“Oranges are great on their own or sliced on top of a salad.”

Avocados

Yes, they’re technically a fruit. 

Burgess explained why one of her favorite foods is so good for the body.

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“They are a great source of healthy fats, fiber, antioxidants and other important nutrients,” she said.  

Avocados offer great healthy fats; they contain fiber and antioxidants.
(iStock )

“Research has shown that avocados can help support a strong immune system, heart health and weight management.” 

“Try adding creamy avocados alongside grain bowls, over toast, or mashed into dark chocolate truffles,” Burgess suggested.



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Corneas made from pig skin restore sight in humans: study – The Hill

Story at a glance


  • Corneal implants made from pig skin have restored eyesight into 20 people with damaged or diseased corneas, a new study claims. 

  • The cornea is the clear part of the eye that covers the iris and pupil and allows light to enter the eye. Corneal impairments are the fourth leading cause of blindness, according to the WHO.

  • Researchers hope that the study’s findings mean the implants can serve as an alternative to corneal transplants from humans which can be hard to come by, especially in some countries in Asia, Africa and the Middle East. 

Implants made from pig skin have restored sight in the blind, according to a new study.

The implant used in the study replicates the human cornea — the transparent part of the eye that covers the iris and pupil allowing light to enter — and is made from collagen protein found in pigs.  

In the pilot study, published in journal Nature Biotechnology, the implants were able to restore sight in 20 people with damaged or diseased corneas. Fourteen participants were completely blind prior to the procedure.  


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Patients, who lived in India and Iran, had a condition called keratoconus where the cornea gradually becomes thinner and bulges outward.  

After 24 months of receiving the implants, all the patients had improved vision, according to the study.  

The study crafters, a team of researchers from Sweden, India and Iran, hope that the implants could be a replacement for corneal transplants from humans, which can be hard to come by.  

Experts estimate that there are about 12.7 million people who are waiting for donated corneas, with only one cornea available for every 70 people in need of a transplant, the study states.  

Lack of access to donated corneas is even more severe in lower to middle-income countries in Asia, Africa and the Middle East.  

“The results show that it is possible to develop a biomaterial that meets all the criteria for being used as human implants, which can be mass produced and stored up to two years and thereby reach even more people with vision problems,” said Neil Lagali, co-author of the study and professor at Linkoping University in Sweden. 

“This gets us around the problem of shortage of donated corneal tissue and access to other treatments for eye diseases.” 


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Why anal sex ‘taboos’ put ‘generation of women’ at risk: doctors

Anal sex isn’t the taboo sex act it used to be — especially among heterosexual women.

Indeed, the most recent statistics provided by the Centers for Disease Control and the National Center for Health Statistics showed that more than a third — 35% — of women aged 15 to 49 have tried anal sex with a male partner.

Those numbers, taken from a survey of more than 5,500 women between 2015 and 2019, are rising — perhaps by a lot, depending on who you ask. A similar survey of 880 “sexually active adults,” conducted by doctor-led butt health brand Future Method, showed that 70% of women have tried anal sex at least once.

In the spirit of a new age of sexual exploration and health awareness, a duo of surgical researchers published an editorial in the BMJ this week, urging more clinicians to talk to women about the potential risks of engaging in anal sex — particularly for those who feel pressured by their partners to do so.

“Clinicians may shy away from these discussions, influenced by society’s taboos,” wrote Tabitha Gana and Lesley Hunt, colorectal and consultant surgeons, respectively, with the UK’s National Health System. “By avoiding these discussions, we may be failing a generation of young women, who are unaware of the risks.”

Physicians and healthcare workers, especially those in primary care and family medicine, “have a duty to acknowledge changes in society around anal sex in young women, and to meet these changes with open neutral and non-judgemental conversations to ensure that all women have the information they need to make informed choices about sex,” the colleagues wrote.

Silence on the albeit sensitive subject, they continued, “exposes women to missed diagnoses, futile treatments, and further harm arising from a lack of medical advice.”

Gana and Hunt referred to a national survey of British women that outlined the top reasons why they’ve tried anal sex, including curiosity and personal pleasure. Unfortunately, for approximately a quarter of women, pressure from their male partners has played a significant role. The US is meanwhile expected to reflect similar trends.

“The pain and bleeding women report after anal sex is indicative of trauma, and risks may be increased if anal sex is coerced,” they wrote.

Anal sex can be safe and enjoyable for many, but the authors warned there are anatomical features to women that bring a different set of risks, such as incontinence, due to their “less robust” sphincter and weaker anal canal muscles compared to men. That’s one reason why women who engage in the act show increased rates of fecal incontinence and anal injury.

The surgeons point out that a majority of medical literature for patients pertaining to anal sex focuses on sexually transmitted illnesses, such as HIV, herpes and HPV — which can lead to certain cancers — but misses the aforementioned physiological risks, as well as the emotional toll of coercion.

In the absence of clinical guidance, women are looking to a “plethora of non-medical or pseudomedical websites to fill the health information void,” some of which “may increase societal pressure to try anal sex,” rather than helping women “make informed decisions,” the authors said.

“Hit television shows such as ‘Sex and the City‘ and ‘Fleabag’ may unwittingly add to the pressure, as they seem to normalize anal sex in heterosexual relationships or make it appear racy and daring,” they added.

Beyond shame or stigma, the doctors urge clinicians to overcome the fear of coming off as “judgmental” or even “homophobic” by raising these concerns with patients — insisting there are resources for them to learn how to approach the subject in a conscientious way.

“With better information, women who want anal sex would be able to protect themselves more effectively from possible harm, and those who agree to anal sex reluctantly to meet society’s expectations or please partners, may feel better empowered to say no,” Gana and Hunt conclude.

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