All posts by Admin

New China COVID rules spur concern as some cities halt routine tests

  • Regular COVID testing no longer required in several cities
  • China eased various virus curbs last Friday
  • Communities worried over virus spread under relaxed rules
  • Major cities including Beijing report record cases for Nov 13

BEIJING, Nov 14 (Reuters) – Several Chinese cities began cutting routine community COVID-19 testing on Monday, days after China announced an easing of some of its heavy-handed coronavirus measures, sparking worry in some communities as nationwide cases continued to rise.

In the northern city of Shijiazhuang, some families expressed concern about exposing their children to the virus at school, giving excuses such as toothaches or earaches for their children’s absence, according to social media posts following a state media report that testing in the city would end.

Other cities, including Yanji in the northeast and Hefei in the east, also said they will stop routine community COVID testing, according to official notices, halting a practice that has become a major fiscal burden for communities across China.

On Friday, the National Health Commission updated its COVID rules in the most significant easing of curbs yet, describing the changes as an “optimisation” of its measures to soften the impact on people’s lives, even as China sticks to its zero-COVID policy nearly three years into the pandemic.

The move, which cut quarantine times for close contacts of cases and inbound travellers by two days, to eight days total, was applauded by investors, even though many experts don’t expect China to begin significant easing until March or April at the earliest.

The changes come even as several major cities including Beijing logged record infections on Monday, posing a challenge for authorities scrambling to quell outbreaks quickly while trying to minimise the impact on people’s lives and the economy.

Some areas of Beijing are requiring daily tests.

The concern and confusion in Shijiazhuang was a top-five trending topic on the Twitter-like Weibo.

The city’s Communist Party chief, Zhang Chaochao, said its “optimisation” of prevention measures should not be seen as authorities “lying flat” – an expression for inaction – nor is Shijiazhuang moving towards “full liberation” from COVID curbs.

The city, about 295 kms (183 miles) southwest of Beijing, reported 544 infections for Sunday, only three of which it categorised as symptomatic.

“I’m a little scared. In the future, public places will not look at nucleic acid tests, and nucleic acid test points will also be closed, everyone needs to pay for the tests,” one Weibo user wrote, referring to Shijiazhuang.

Gavekal Research said in a Monday note that it was “curious timing” for China to relax its COVID policies: “The combination of an intensifying outbreak and loosening central requirements has led to debate over whether China is now gradually moving to a de facto policy of tolerating Covid,” it said.

FRESH RECORDS

Nationwide, 16,072 new locally transmitted cases were reported by the National Health Commission, up from 14,761 on Sunday and the most in China since April 25, when Shanghai was battling an outbreak that locked down the city for two months.

Beijing, Chongqing, Guangzhou and Zhengzhou all recorded their worst days so far, though in the capital city the tally was a few hundred cases, while the other cities were counting in thousands.

Case numbers are small compared with infection levels in other countries, but China’s insistence on clearing outbreaks as soon as they emerge under its zero-COVID policy has been widely disruptive to daily life and the economy.

Under the new rules unveiled on Friday, individuals, neighbourhoods and public spaces can still be subject to lockdowns, but the health commission relaxed some measures.

In addition to shortening quarantines, secondary close contacts are no longer identified and put into isolation – removing what had been a major inconvenience for people caught up in contact-tracing efforts when a case is found.

Despite the loosening of curbs, many experts described the measures as incremental, with some predicting that China is unlikely to begin reopening until after the March session of parliament, at the earliest.

Analysts at Goldman Sachs said on Monday that rising cases in cities including Guangzhou and Chongqing and the continuation of the zero-COVID policy pose downside near-term economic risks.

Reporting by Liz Lee, Jason Xue, Wang Jing and Ryan Woo; Editing by Simon Cameron-Moore, Tony Munroe and Emelia Sithole-Matarise

Our Standards: The Thomson Reuters Trust Principles.

Read original article here

Jennifer Aniston Strips Down To A Robe With Her Natural Curls On Display As Fans React: ‘Stunning’

Jennifer Aniston

Jennifer Aniston made ‘the Rachel’ famous in the nineties – and we haven’t been able to stop lusting after her hair ever since! The 53-year-old Friends alum proved that her hair is so much more than the iconic nineties cut, as she treated her fans to a video of her natural curly hair on social media, leaving them well and truly speechless!

Jennifer Aniston Shows Fans How She Styles Her Natural Curly Hair

The Morning Show star took to Instagram on November 2nd to show her fans a candid video of herself styling her freshly-washed hair in her bathroom. She appears to have just gotten out of the shower, as she is wearing a chic blue robe in the video, and she then proceeds to style her hair into an effortless beach wave style with a little help from her LolaVie brand’s Lightweight Hair Oil.

The Horrible Bosses actress appears to squeeze a small amount of oil into her hands, and then massage it into her hands, before scrunching it into her natural, curly hair. Jen captioned her video: “Air dry and a little bit of @lolavie,” and her fans couldn’t help but rave about the results in the comments section.

READ MORE: Young Jennifer Aniston: Throwback Moments of This Hollywood Icon

Famous Friends And Fans Shower Jennifer With Compliments

“You are the most natural stunning goddess,” Jenna Dewan commented, followed by a star emoji, while Julia Roberts said, “Love this and you,” followed by a shooting star emoji. “Love the waves and air dry” Rita Wilson exclaimed, while Michelle Pfeiffer wrote, “Love!” in all caps, followed by three fire emojis. “You’re stunning,” Rita Ora added, followed by the heart eyes emoji. Who knew Jennifer had so many A-list friends?!

Jennifer’s Previous LolaVie videos

Of course this isn’t the first time that the Marley & Me actress has shown fans how she personally uses her LolaVie hair products since launching the brand in September 2021. Just a few months ago, she told fans the “secret” to her glossy, shiny locks, and even showed them a video of how she achieved her enviable shiny locks by using the products from her brand.

READ MORE: Jennifer Aniston Glows In Rare Hair Styling Video As Fans Go Wild For Her ‘Extra Shine’ Hack

Jennifer Aniston Details Past Fertility Struggles In Heartbreaking ‘Allure’ Interview

As well as wowing her fans with her hair, the We’re the Millers star has been hitting the headlines for other reasons this week too, thanks to her extremely candid interview with Allure that revealed her past fertility struggles. Jennifer was the cover star of the magazine’s final print issue, and didn’t hold back in the accompanying interview, revealing her struggles with fertility and IVF for the first time ever.

“I was trying to get pregnant,” Jen revealed about trying to start a family many years ago, adding that the constant media speculation about whether she was or wasn’t pregnant made it even harder. “It was a challenging road for me, the baby-making road. All the years and years and years of speculation… It was really hard,” she continued. “I was going through IVF, drinking Chinese teas, you name it. I was throwing everything at it.”

The Murder Mystery actress also touched on the constant rumors that first husband Brad Pitt, who she was married to between 2000 and 2005, left her because she didn’t want to have a baby with him, as well as the cruel media comments that called her “selfish” and too career-focused to start a family. “People thought I just cared about my career. And God forbid a woman is successful and doesn’t have a child,” she added. “And the reason my husband left me, why we broke up and ended our marriage, was because I wouldn’t give him a kid. It was absolute lies. I don’t have anything to hide at this point.”

READ MORE: Jennifer Aniston Steps Out In A Black Turtleneck While Filming ‘The Morning Show’ With Jon Hamm In New York City

Read original article here

Kim Kardashian Daughter North Says ‘the Conjuring 3’ Is Favorite Movie

  • Kim Kardashian’s daughter said in a now-deleted TikTok “The Conjuring 3” is her “favorite movie.”
  • North West, 9, said on Sunday that she watches the R-rated film as part of her morning routine.
  • The video has been taken off the platform after reportedly receiving over 900,000 views.

Kim Kardashian’s daughter North West said that watching “The Conjuring 3: The Devil Made Me Do It” is part of her morning routine.

On Sunday, North shared her daily routine with the audience of her joint account with her mother, @KimandNorth.

The 9-year-old began her video by saying she likes to start her day watching her “favorite movie” and showed “The Conjuring 3” landing page on Netflix.

The horror movie, which came out in 2021, has been rated R for terror, violence, and some disturbing images.

According to Mirror Online, the video gained 900,000 views before it was taken off the app. 

This is not the first time North has published something controversial on the platform.

Last year, it appeared that North had gone live on the account without her mother’s permission and gave a tour of her family’s home in Hidden Hills, California.

The live video eventually ended when Kardashian found out and ended the live stream.

Following that incident, Kardashian said on the podcast “Honestly with Bari Weiss” that it was “inevitable” that her eldest daughter would break their social media rules because she is the daughter of another rule-breaker, Ye, formerly known as Kanye West.

Kim Kardashian and North West at Paris Fashion Week July 2022.

Pierre Suu/Getty Images



“I mean, North West is Kanye West’s daughter,” Kardashian said. “Forget that, she’s his twin. So she will definitely do all of the above. But in my household, there are rules.”

The reality star added that North apologized after the incident.

“She said, ‘I saw on TikTok that I got in trouble and I’m really sorry,'” Kardashian said. “And she got it.”

In March, a court ruled that Kardashian was officially legally single after the SKIMS founder filed for divorce in February 2021 from her ex-husband Ye. The pair share North and three younger children — Saint, Chicago, and Psalm.

Earlier this year, Ye made numerous negative comments about her daughter posting videos on TikTok. In response, Kardashian wrote on her Instagram Story that Ye’s “constant attacks” were “more hurtful than any TikTok North West might create.” 

“As the parent who is the main provider and caregiver for our children, I am doing my best to protect our daughter while also allowing her to express her creativity,” Kardashian wrote. “Divorce is difficult enough on our children and Kanye’s obsession with trying to control and manipulate our situation so negatively and publicly is only causing further pain for all.”

Later in the post, Kardashian said she wanted “nothing but a healthy and supportive co-parenting relationship” and wished to handle all matters regarding the pair’s children privately. 

Less than a week later, Ye deleted all the posts about North West and the rest of their children.

Read original article here

Scientists Reveal the Secret to a Strange Animal’s Eternal Youth

Cross-section through a tentacle of a transgenic sea anemone showing differentiation products of the SoxC cell population (magenta) and retractor muscles (yellow). Credit: Andreas Denner

In sea anemones, highly conserved genes guarantee the lifelong differentiation of neurons and glandular cells.

Sea anemones are seemingly immortal animals. They seem to be immune to aging and the negative impacts that humans experience over time. However, the exact reasons for their eternal youth are not completely understood. 

The genetic fingerprint of the sea anemone Nematostella vectensis reveals that members of this incredibly ancient animal phylum employ the same gene cascades for neural cell differentiation as more complex organisms. These genes are also in charge of maintaining the balance of all cells in the organism during the anemone’s lifetime. These findings were recently published in the journal Cell Reports by a group of developmental biologists headed by Ulrich Technau of the University of Vienna.

Almost all animal organisms are made up of millions, if not billions, of cells that join together in intricate ways to create specific tissues and organs, which are made up of a range of cell types, such as a variety of neurons and gland cells. However, it is unclear how this critical balance of diverse cell types emerges, how it is regulated, and if the different cell types of different animal organisms have a common origin.

Optical longitudinal section of a sea anemone with nanos1-transgenic neuronal cells (red) in both cell layers. Muscles are stained green, cell nuclei in blue. Credit: Andreas Denner

Single-cell fingerprint leads to common ancestors

The research group, led by evolutionary developmental biologist Ulrich Technau, who is also head of the Single Cell Regulation of Stem Cells (SinCeReSt) research platform at the University of Vienna, has deciphered the diversity and evolution of all nerve and gland cell types and their developmental origins in the sea anemone Nematostella vectensis.

In order to achieve this, they used single cell transcriptomics, a method that has revolutionized biomedicine and evolutionary biology over the past decade.

“With this, entire organisms can be resolved into single cells – and the entirety of all currently expressed genes in each individual cell can be decoded. Different cell types fundamentally differ in the genes they express. Therefore, single cell transcriptomics can be used to determine the molecular fingerprint of each individual cell,” explains Julia Steger, the first author of the current publication.

In the study, cells with an overlapping fingerprint were grouped. This allowed the scientists to distinguish defined cell types or cells in transitional stages of development, each with unique expression combinations. It also allowed the researchers to identify the common progenitor and stem cell populations of the different tissues.

To their surprise, they found that contrary to earlier assumptions, neurons, glandular cells, and other sensory cells originate from one common progenitor population, which could be verified by genetic labeling in living animals. Since some gland cells with neuronal functions are also known in vertebrates, this could indicate a very old evolutionary relationship between gland cells and neurons.

Ancient genes in constant use

One gene plays a special role in the development of these common ancestor cells. SoxC is expressed in all precursor cells of neurons, gland cells, and cnidocytes and is essential for the formation of all these cell types, as the authors were additionally able to show in knockout experiments.

“Interestingly, this gene is no stranger: It also plays an important role in the formation of the nervous system in humans and many other animals, which, together with other data, shows that these key regulatory mechanisms of nerve cell differentiation seem to be conserved across the animal kingdom,” says Technau.

By comparing different life stages, the authors also found that in sea anemones, the genetic processes of neuron development are maintained from the embryo to the adult organism, therefore contributing to the balance of neurons throughout the life of Nematostella Vectensis.

This is remarkable because, unlike humans, sea anemones can replace missing or damaged neurons throughout their lives. For future research, this raises the question of how the sea anemone manages to maintain these mechanisms, which in more complex organisms only occur in the embryonic stage, into the adult organism in a controlled manner.

Reference: “Single-cell transcriptomics identifies conserved regulators of neuroglandular lineages” by Julia Steger, Alison G. Cole, Andreas Denner, Tatiana Lebedeva, Grigory Genikhovich, Alexander Ries, Robert Reischl, Elisabeth Taudes, Mark Lassnig and Ulrich Technau, 20 September 2022, Cell Reports.
DOI: 10.1016/j.celrep.2022.111370



Read original article here

Biden and Xi sit down for high-stakes first in-person meeting as presidents


Bali, Indonesia
CNN
 — 

President Joe Biden on Monday greeted his Chinese counterpart Xi Jinping in person for the first time since taking office, their handshake launching high-stakes talks whose effects could ripple around the world.

Biden and Xi walked toward each other from opposite sides of a hotel lobby and shook hands in front of a row of US and Chinese flags just after 5:30 p.m. local time. They smiled for cameras and Xi – through a translator – appeared to say, “Good to see you.”

“As leaders of our two nations, we share responsibility, in my view, to show that China and the United States can manage our differences, prevent competition from becoming anything ever nearing conflict and to find ways to work together on urgent global issues that require our mutual cooperation,” Biden said as the talks got underway.

“The world expects, I believe, China and the United States to play key roles in addressing global challenges,” he said.

Speaking second, Xi seemed to offer what could be interpreted as a pointed message to his counterpart, who has spent more than half-a-century on the world stage.

“A statesman should think about and know where to lead his country,” Xi said through a translator. “He should also think about and know how to get along with other countries and the wider world.”

The two leaders’ talks Monday may last only a few hours, but could have consequences stretching months or even years as the world’s largest economies veer toward increasingly hostile relations.

The moments spent together on the sidelines of the Group of 20 summit here will amount to only a fraction of the time the two men have been in each other’s company since 2011. Biden has claimed that as vice president, he spent north of 70 hours with Xi and traveled 17,000 miles with him across China and the United States – both exaggerations, but still reflective of a relationship that is now perhaps the most important on the planet.

Biden hopes coming face-to-face again after nearly two years communicating only by phone and video-conference can yield a more strategically valuable result, even if he enters the talks with little expectation they can produce anything concrete.

At the beginning of their bilateral meeting in Bali, Biden said he found substance in “face-to-face discussions” between the two leaders.

“As you know, I’m committed to keeping lines of communications open – between you and me personally but our government across the board, as our two countries have so much that we have an opportunity to deal with,” Biden said.

The meeting Monday begins at a remarkably low moment in US-China ties.

Relations have deteriorated rapidly amid economic disputes and an increasingly militarized standoff over Taiwan. The tensions have led to a decline in cooperation on areas where the two countries once shared common interests, like combating climate change and containing North Korea’s nuclear program.

In a national security strategy document released last month, Biden for the first time identified China as posing “America’s most consequential geopolitical challenge,” and wrote the country was the “only competitor with both the intent to reshape the international order and, increasingly, the economic, diplomatic, military, and technological power to advance that objective.”

There was almost no expectation among American officials that any of those issues could be resolved simply by getting Biden and Xi in the same room. The prospect of a joint statement to be released afterward was considered a nonstarter.

Just arranging the meeting itself required US and Chinese officials to establish lines of communication after Beijing furiously cut off most channels following House Speaker Nancy Pelosi’s visit to Taiwan over the summer.

“Every matter associated with this meeting, from phone calls to logistics, has been very carefully considered, negotiated, and engaged between the two sides,” a senior US administration official said.

Planning for Monday’s meeting predated Pelosi’s trip, and discussions continued between US and Chinese officials despite Beijing’s furor. The process was “serious, very sustained and professional in the best traditions of US-China diplomacy,” the official said.

A second official acknowledged the talks setting up the meeting were not always friendly.

“I won’t say that the conversations weren’t contentious because obviously there’s lots of areas where we have differences and challenges,” the official said. “The dozens of hours we have spent talking to our Chinese counterparts has definitely surfaced many of those issues.”

For his part, Biden takes meetings like this “incredibly seriously” and reads extensively beforehand. In meetings with advisers, he runs through various scenarios for how the meeting might go.

“He goes through ‘if this happens, then should we handle it this way,’” the first official said. “He understands that this is, in many respects, the most important bilateral relationship. And it’s his responsibility to manage it well and he takes that very, very seriously.”

Officials said in Monday’s meeting they expected Biden’s senior-most advisers to accompany him as part of his official delegation. And the said they expected Xi to similarly surround himself with top aides, though the US team entered the meeting expecting to see some new faces on the Chinese side amid an ongoing transition inside Xi’s inner circle.

Biden’s aides have not set a time limit for the meeting, though Jake Sullivan, the US national security adviser, said he expected the talks to run “a couple hours” but could extend longer.

“It’s a meeting on the margins of an international summit. So it’s not itself a kind of summit where they’re coming together in a third country or in Washington and Beijing,” he said. “So, we haven’t set a time limit on the conversation.”

Sullivan said Biden would be “totally straightforward and direct” in the meeting, and expected Xi to be similarly candid in return.

Of most interest to Biden and his aides is establishing some level of understanding with Xi about where the administration views the relationship with China, and learning from him how he sees ties with the United States going forward.

The White House has used the phrase “building a floor” to describe the goal of the talks, suggesting both that Biden hopes to stop relations from falling any further and that he sees the potential for improvement.

“We just got to figure out where the red lines are and what are the most important things to each of us going into the next two years,” Biden told reporters Sunday in Cambodia, where he was attending summit meetings with Asian leaders before traveling to Bali.

Speaking to a small group of reporters in Bali ahead of Biden’s meeting Monday, Treasury Secretary Janet Yellen suggested the face-to-face was intended to stabilize a teetering relationship, and detailed hopes it would lay the groundwork for “intensive” bilateral economic engagement.

“What I’m very much hoping is that it’s a result of the President’s bilateral role with President Xi today, we’ll engage in more intensive conversations going forward with our Chinese counterparts about the Chinese economy, global macroeconomic outcomes, and how policies both in the US and China are impacting those outcomes.”

For Xi, the trip to Bali also marks his first journey abroad since the onset of the Covid pandemic, which prompted the Chinese government to impose strict lock downs and draconian restrictions. Xi’s reemergence on the physical world stage also comes on the heels of China’s Communist Party Congress in Beijing, during which he secured a norm-breaking third term as its leader.

Even a week ago, most inside the White House were expecting Biden to enter the talks comparatively weakened by Democratic losses in the midterm elections. But better-than-expected results for Democrats left the president feeling as if he was entering his meetings this week with the wind at his back, according to top aides.

“I know I’m coming in stronger, but I don’t need that,” Biden said of his own improved political fortunes on Saturday.

US officials previewing the meeting have stressed the Biden administration is not looking to come out of it with specific “deliverables,” including a joint statement listing areas of potential cooperation. Rather, the setting is aimed at offering both Biden and Xi a significant opportunity to better share their respective countries’ goals and perspectives.

“Xi is not an enigma to President Biden,” a senior administration official told CNN. “He knows him. And he is mindful of where Xi is trying to take China. He sees China as a competitor, and he feels confident the US can win that competition.”

China’s pandemic-era isolation, US officials say, had made it relatively harder in recent years to get a read on Beijing’s intentions abroad as Xi declined to travel outside of China – but they believe that is all about to change.

“We can expect them to be more assertive on the world stage,” the senior administration said. But, they added: “What that looks like is difficult to know right now.”

Sullivan said this week that finally substituting the pandemic-era video calls with a face-to-face meeting for the first time since Biden took office “takes the conversation to a different level strategically and allows the leaders to explore in deeper detail what each of them see in terms of their intentions and priorities.”

Read original article here

Key cause of type 2 diabetes confirmed: Chemicals produced to break down sugar worsens condition

How high blood sugar REALLY causes type 2 diabetes: Chemicals produced when glucose is broken down are to blame, study finds

  • Oxford University researchers looked into how type 2 diabetes progresses 
  • Found chemicals released when sugar is broken down cause patients’ decline
  • Discovery could lead to new treatments that could slow the condition’s effects 

For decades, scientists have been puzzled over how exactly high blood sugar causes type 2 diabetes.

But Oxford University researchers may finally have the answer.

Tests revealed it wasn’t the elevated glucose levels that were directly to blame for the pancreas being robbed of its insulin-making ability. 

Instead, they found glucose metabolites — the chemicals released when sugar is broken down — rather than glucose itself is behind the decline.

The discovery could lead to diabetes patients being given new treatments to slow down glucose metabolism, preventing the condition getting worse, they said.

Type 2 diabetes affects approximately 2million people in Britain and 37million in the US. It occurs when blood sugar is too high, which can lead to complications including blindness, kidney failure and nerve damage if left uncontrolled.

Patients are currently encouraged to eat well and exercise to maintain a healthy weight to slow its progression.

Medication like Glucophage to improve insulin function is usually prescribed later on if diet and exercise is not effective alone.

However, the latest research could lead to new drugs that could stop the disease getting to that point in the first place.

Oxford University researchers found glucose metabolites — the chemicals released when sugar is broke down — rather than glucose itself is behind type 2 diabetes progression

WHAT IS TYPE 2 DIABETES? 

Type 2 diabetes is a condition which causes a person’s blood sugar to get too high.

More than 4million people in the UK are thought to have some form of diabetes.

Type 2 diabetes is associated with being overweight and you may be more likely to get it if it’s in the family.

The condition means the body does not react properly to insulin – the hormone which controls absorption of sugar into the blood – and cannot properly regulate sugar glucose levels in the blood.

Excess fat in the liver increases the risk of developing type 2 diabetes as the buildup makes it harder to control glucose levels, and also makes the body more resistant to insulin. 

Weight loss is the key to reducing liver fat and getting symptoms under control.

Symptoms include tiredness, feeling thirsty, and frequent urination.

It can lead to more serious problems with nerves, vision and the heart.

Treatment usually involves changing your diet and lifestyle, but more serious cases may require medication.

Source: NHS Choices; Diabetes.co.uk

 

<!- - ad: https://mads.dailymail.co.uk/v8/de/health/none/article/other/mpu_factbox.html?id=mpu_factbox_1 - ->

Advertisement

Co-author Professor Frances Ashcroft, a physiologist, said: ‘This is potentially a useful way to try to prevent beta-cell decline in diabetes. 

‘Because glucose metabolism normally stimulates insulin secretion, it was previously hypothesised that increasing glucose metabolism would enhance insulin secretion in T2D [type 2 diabetes] and glucokinase activators were trialled, with varying results.’

She added: ‘Our data suggests that glucokinase activators could have an adverse effect and, somewhat counter-intuitively, that a glucokinase inhibitor might be a better strategy to treat T2D. 

‘Of course, it would be important to reduce glucose flux in T2D to that found in people without diabetes — and no further. 

‘But there is a very long way to go before we can tell if this approach would be useful for treating beta-cell decline in T2D. 

‘In the meantime, the key message from our study if you have type 2 diabetes is that it is important to keep your blood glucose well controlled.’

The study, published in the journal Nature Communications, looked at the effects of hypoglycaemia — high blood sugar — in diabetic mice.

They measured how much insulin the mice released when given sugar for those with low blood glucose and those with chronic hypoglycaemia.

Mice were given drugs that blocked glucokinase — an enzyme that aids the break down of blood glucose — for two days to see whether it was glucose or the break down of glucose that causes the normally lower levels of insulin in those with hypoglycaemia.

Results showed the drug had little effect on the low blood sugar mice but ‘largely prevented the dramatic reduction in GSIS and insulin content produced by chronic hyperglycaemia’.

This lower levels of insulin in those with hypoglacaemia was being caused by the breakdown of glucose, not the sugar itself, the team said. 

When people eat carbohydrates, the food is broken down into blood sugar. This tells the pancreas to release insulin, which allows glucose to enter the body’s cells.

But over time, high blood sugar levels can cause insulin resistance. 

Because the insulin isn’t as effective at breaking down the sugars, it causes the body to produce more and more of it.

Eventually, this leads to the pancreas becoming worn out, sending the system out of whack and causing blood sugar levels to stay high.



Read original article here

Random: God Of War: Ragnarok Director Shares Five NES Games That Inspired Him

Image: Sony Interactive Entertainment

Santa Monica Studios’ God of War: Ragnarok recently launched to critical acclaim (including a glowing review from our good pals over at Push Square), and its director Eric Williams has recently shared some of the games that inspired him and influenced his career.

Speaking with IGN (thanks, GoNintendo), Williams listed off five classic NES titles that informed how he approaches various aspects of game design, including combat, statistics, and day/night cycles. As expected, a few of his choices might seem pretty obvious to many of our readers here, but there are a couple that might come as a bit of a surprise.

The first game listed is, of couse, The Legend of Zelda. While not exactly a game that ranks highly in Nintendo’s Zelda franchise these days, the impact of its introduction on the NES cannot be overstated. Williams states that “being from the Midwest and playing in the woods as a kid made this game feel so familiar and fantastical all at the same time.”

The second is Castlevania II: Simon’s Quest. The sophomore entry to the Castlevania franchise, Simon’s Quest is often left in the shadow of both its predecessor and immediate sequel, but Williams is a big fan of the game’s “town, the day/night, the insane secrets”, and “the monster mythology.”

Next up is Mike Tyson’s Punch-Out!!, a game that we just recently covered in out regular Box Art Brawl feature. Williams is a big fan of the combat showcased here (as are we!) and states that “the patterns, mechanics, techniques, and challenge of this game informed all of my early notions of what a “good” combat system should be.”

The fourth game is Baseball Stars, an SNK game that became particularly successfull in the US when it launched in 1989. It was well received by critics at the time for its gameplay, but Williams found more inspiration from the game’s economy mechanics, stating that “this game had a salary system that taught me the fundamentals of stats and economy systems.”

Finally, the last game listed by Williams is River City Ransom, a title that the director states influenced his approach to themes within video games. He states, “theme is very important to me and this game’s theme of being a ‘kid’ was so strong. Playground gangs, sports, weapons, comics to learn abilities, even the low money cap felt like lunch money or allowance values true of the time.”

So there you have it! It’s always nice to see how the creators behind some of the world’s most critically acclaimed games find their inspiration. Even though NES games may well seem somewhat primitive to youngsters these days, there’s absolutely no denying the varying influence they had on modern gaming. Nice one, NES!

Have you played Ragnarok yet? Do you agree with Williams’ assessments on these five NES games? Let us know!



Read original article here

European markets cautious as investors assess Fed outlook

Stocks on the move: Informa up 6%, Roche down 4%

Shares of Informa climbed more than 6% in early trade to lead the Stoxx 600 after the British publishing company upgraded its 2022 guidance.

At the bottom of the Stoxx 600, Roche fell 4.7% after the Swiss pharmaceutical company’s Alzheimer’s drug candidate failed two long-awaited trials.

– Elliot Smith

Bitcoin falls below $16,000 to lowest since Nov. 2020 as FTX saga continues

CNBC Pro: One retail stock just hit an all-time high — and Bank of America thinks it’s got further to go

This year’s bear market has wiped trillions of dollars in market cap off the stock market, but a few stocks have outperformed significantly during this period.

Bank of America identified three retail stocks that bucked the trend, and says one remains a buy.

Pro subscribers can read more here.

— Zavier Ong

CNBC Pro: UBS says disinflation is on the way — and shares 8 global stocks to play it

Swiss bank UBS has forecasted a “sharp” disinflation in 2023.

It said weak growth alongside “mechanical” indicators, such as easing supply chain bottlenecks and rising goods inventories, would see prices fall next year.

The investment bank screened for stocks that would benefit from such an environment.

CNBC Pro subscribers can read more about their forecasts, and eight stocks we’ve highlighted from their list.

— Ganesh Rao

European markets: Here are the opening calls

European markets are set to open in positive territory on Monday with global markets still seeing a boost from last week’s U.S. inflation figures, which showed prices had risen less than expected in October.

The U.K.’s FTSE index is expected to open 13 points higher at 7,338, Germany’s DAX up 45 points at 14,283, France’s CAC up 30 points at 6,627 and Italy’s FTSE MIB down 136 points at 24,459, according to data from IG.

Data releases include euro zone industrial production figures for September. There are no major earnings.

— Holly Ellyatt

Read original article here

3 killed, 2 hurt after shooting on University of Virginia campus

Three people are dead and two others are hurt after a shooting on the University of Virginia’s campus in Charlottesville Sunday night. Students are still being advised to shelter in place and classes are canceled Monday, according to an email from the University’s President Jim Ryan.

Three people are dead and two others are hurt after a shooting on the University of Virginia’s campus in Charlottesville Sunday night.

Students are still being advised to shelter in place and classes are canceled Monday, according to a letter from the University’s President Jim Ryan.

“Around 10:30 p.m. last night, there was a shooting on Grounds. One of our students, Christopher Darnell Jones, Jr., is suspected to have committed the shooting. The suspect remains at large and is considered armed and dangerous. Multiple law enforcement agencies are coordinating to find and apprehend him. He was last seen wearing a burgundy jacket, blue jeans, and red shoes, and he may be driving a black SUV with VA license plate number TWX3580. First and foremost, please continue to follow the guidance you receive though the UVA alert system, which is currently to shelter in place,” Ryan wrote in a letter to the university community around 4 a.m.



Campus police identified Jones in connection with the shooting. Police said they’re looking for a Black SUV with Virginia license plate TWX3580, according to a string of tweets from the school.

Jones is listed as a student athlete on the university’s website — and considered armed and dangerous.

Around 10:30 p.m. The University of Virginia Office of Emergency Management reported shots fired at Culbreth Garage near the center of the campus in a tweet. The office said multiple police agencies are searching for the suspect.

Ryan urged the community to follow U.Va. Emergency Management for updates.

In a letter, Ryan said the university would make plans to grieve after the suspect is taken into custody.

“This is a message any leader hopes never to have to send, and I am devastated that this violence has visited the University of Virginia,” Ryan wrote in a letter.

Robyn S. Hadley, the school’s vice president, sent an email to students, asking that they take the campus alerts seriously.

“Please, please take the shelter in place commands seriously as the situation remains active. The suspect is armed and dangerous. If you are not inside and safe, immediately seek safety,” Hadley said.

A post on Twitter from the Office of Emergency Management around the time of the shooting advised students to “RUN HIDE FIGHT.”

The school advised those on campus to keep friends and family informed of their situation.

The university has established an emergency hotline at 877-685-4836.

Like WTOP on Facebook and follow WTOP on Twitter and Instagram to engage in conversation about this article and others.

Get breaking news and daily headlines delivered to your email inbox by signing up here.

© 2022 WTOP. All Rights Reserved. This website is not intended for users located within the European Economic Area.



Read original article here

University of Virginia shooting: 3 dead, 2 others wounded as police search for suspect



CNN
 — 

A shooter killed three people and wounded two others at the University of Virginia’s main campus in Charlottesville on Sunday, and the suspect – identified as a school student – remains at large, university president Jim Ryan said in a statement issued Monday.

The campus was advised to shelter-in-place around 10:40 p.m. following a shooting reported on Culbreth Road, the University of Virginia Police Department tweeted. It has been in lockdown as authorities search for the suspect.

The suspect, identified by police as Christopher Darnell Jones, Jr., is believed to be armed and dangerous. He’s described as wearing a burgundy jacket with blue jeans and red shoes, and may be driving a black SUV, according to police.

The two wounded individuals are receiving medical care, Ryan said, adding that he was devastated “that this violence has visited the University of Virginia.” Monday classes have been canceled.

University officials have not identified the victims or stated whether they were students.

Authorities said Monday morning that multiple police departments are actively searching for Jones, including the use of a Virginia State Police helicopter.

Jones is listed on the university’s athletics website as a football player in 2018, who as a freshman did not participate in any games. It is unclear if he is still a student at UVA.

CNN has reached out to campus police for more information.

UVA vice president and chief student affairs officer Robyn S. Hadley told students to “take the shelter in place commands seriously as the situation remains active.”

“We have all received several shelter in place texts, and they are frightening,” Hadley said in an email to UVA’s student body.

“I am on grounds like many of you; I am sheltering in place and in direct touch with University leadership and UPD … If you are not inside and safe, immediately seek safety,” Hadley said, adding that multiple police jurisdictions were working to locate the suspect.



Read original article here